Peptide A
Residue A
Peptide B
Residue B
Thiol Separation (Å)
HSE
Redox Score
Known Redox Activity
Loading...
Acidic amino acid decarboxylase GADL1
34
Acidic amino acid decarboxylase GADL1
34
3.9
83
0.31
E9QP13E9QP13E9QP13E9QP13carboxylicacidmetabolicprocess
Insulin
93
Insulin
31
9.1
54
0.2
INSINSP01315P01315activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessglycoproteinbiosyntheticprocessinsulinreceptorsignalingpathwaylactatebiosyntheticprocesslipidbiosyntheticprocesslipoproteinbiosyntheticprocessnegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofDNAreplicationpositiveregulationoffattyacidbiosyntheticprocesspositiveregulationofglucoseimportpositiveregulationofglucosemetabolicprocesspositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipoproteinlipaseactivitypositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationtoplasmamembraneregulationoftransmembranetransporteractivityresponsetoL-argininevasodilationwoundhealing
Insulin
98
Insulin
31
9.5
51
0.21
INSINSP01315P01315activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessglycoproteinbiosyntheticprocessinsulinreceptorsignalingpathwaylactatebiosyntheticprocesslipidbiosyntheticprocesslipoproteinbiosyntheticprocessnegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofDNAreplicationpositiveregulationoffattyacidbiosyntheticprocesspositiveregulationofglucoseimportpositiveregulationofglucosemetabolicprocesspositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipoproteinlipaseactivitypositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationtoplasmamembraneregulationoftransmembranetransporteractivityresponsetoL-argininevasodilationwoundhealing
Copper transport protein ATOX1
15
Copper transport protein ATOX1
15
3.6
82
0.34
ATOX1ATOX1O00244O00244cellularcopperionhomeostasiscopperiontransportresponsetooxidativestress
Nitric oxide synthase, brain
331
Nitric oxide synthase, brain
326
3.7
74
0.37
NOS1NOS1P29476P29476agingargininecatabolicprocessbehavioralresponsetococainebraindevelopmentcellularresponsetoepinephrinestimuluscellularresponsetogrowthfactorstimuluscellularresponsetomechanicalstimulusestablishmentofproteinlocalizationfemalepregnancymulticellularorganismalresponsetostressmusclecontractionnegativeregulationofapoptoticprocessnegativeregulationofbloodpressurenegativeregulationofcalciumiontransportnegativeregulationofcellpopulationproliferationnegativeregulationofcytosoliccalciumionconcentrationnegativeregulationofheartcontractionnegativeregulationofhepaticstellatecellcontractionnegativeregulationofhydrolaseactivitynegativeregulationofinsulinsecretionnegativeregulationofironiontransmembranetransportnegativeregulationofneuronapoptoticprocessnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofpotassiumiontransportnegativeregulationofserotoninuptakenegativeregulationofvasoconstrictionnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionpeptidyl-cysteineS-nitrosylationpositiveregulationofadenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocesspositiveregulationofguanylatecyclaseactivitypositiveregulationofhistoneacetylationpositiveregulationoflong-termsynapticpotentiationpositiveregulationofneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsodiumiontransmembranetransportpositiveregulationoftheforceofheartcontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofheartcontractionregulationofneurogenesisregulationofsensoryperceptionofpainregulationofsodiumiontransportresponsetoactivityresponsetoestrogenresponsetoethanolresponsetoheatresponsetohormoneresponsetohypoxiaresponsetoleadionresponsetolipopolysaccharideresponsetonicotineresponsetonitricoxideresponsetonutrientlevelsresponsetoorganiccycliccompoundresponsetoorganonitrogencompoundresponsetopeptidehormoneresponsetovitaminEretrogradetrans-synapticsignalingbynitricoxidestriatedmusclecontractionsynapticsignalingbynitricoxidevasodilationxenobioticcatabolicprocess
Nitric oxide synthase, brain
331
Nitric oxide synthase, brain
336
3.7
78
0.35
NOS1NOS1P29475P29475argininecatabolicprocesscellredoxhomeostasiscellularresponsetogrowthfactorstimulusmulticellularorganismalresponsetostressmusclecontractionmyoblastfusionnegativeregulationofbloodpressurenegativeregulationofcalciumiontransportnegativeregulationofcalciumiontransportintocytosolnegativeregulationofhydrolaseactivitynegativeregulationofpotassiumiontransportnegativeregulationofserotoninuptakeneurotransmitterbiosyntheticprocessnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionpeptidyl-cysteineS-nitrosylationpositiveregulationofguanylatecyclaseactivitypositiveregulationofhistoneacetylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsodiumiontransmembranetransportpositiveregulationoftheforceofheartcontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofcalciumiontransmembranetransportviahighvoltage-gatedcalciumchannelregulationofcardiacmusclecontractionregulationofryanodine-sensitivecalcium-releasechannelactivityregulationofsodiumiontransportresponsetoheatresponsetohormoneresponsetohypoxiaresponsetolipopolysaccharideretrogradetrans-synapticsignalingbynitricoxidestriatedmusclecontractionvasodilationxenobioticcatabolicprocess
Nitric oxide synthase, brain
336
Nitric oxide synthase, brain
336
3.6
83
0.33
NOS1NOS1P29475P29475argininecatabolicprocesscellredoxhomeostasiscellularresponsetogrowthfactorstimulusmulticellularorganismalresponsetostressmusclecontractionmyoblastfusionnegativeregulationofbloodpressurenegativeregulationofcalciumiontransportnegativeregulationofcalciumiontransportintocytosolnegativeregulationofhydrolaseactivitynegativeregulationofpotassiumiontransportnegativeregulationofserotoninuptakeneurotransmitterbiosyntheticprocessnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionpeptidyl-cysteineS-nitrosylationpositiveregulationofguanylatecyclaseactivitypositiveregulationofhistoneacetylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsodiumiontransmembranetransportpositiveregulationoftheforceofheartcontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofcalciumiontransmembranetransportviahighvoltage-gatedcalciumchannelregulationofcardiacmusclecontractionregulationofryanodine-sensitivecalcium-releasechannelactivityregulationofsodiumiontransportresponsetoheatresponsetohormoneresponsetohypoxiaresponsetolipopolysaccharideretrogradetrans-synapticsignalingbynitricoxidestriatedmusclecontractionvasodilationxenobioticcatabolicprocess
Cytidine deaminase
99
Cytidine deaminase
59
3.6
90
0.31
CDDCDDP56389P56389cellularresponsetoexternalbioticstimulusCMPcatabolicprocesscytidinedeaminationdCMPcatabolicprocessnegativeregulationofcellgrowthnegativeregulationofnucleotidemetabolicprocessresponsetocycloheximideUMPsalvage
Suppressor of cytokine signaling 2
167
Elongin-C
112
8.5
nan
nan
SOCS2ELOCO14508Q15369cellularresponsetohormonestimulusgrowthhormonereceptorsignalingpathwayintracellularsignaltransductionlactationmammaryglandalveolusdevelopmentnegativeregulationofapoptoticprocessnegativeregulationofmulticellularorganismgrowthnegativeregulationofreceptorsignalingpathwayviaJAK-STATphosphatidylinositolphosphatebiosyntheticprocesspositiveregulationofneurondifferentiationproteinubiquitinationreceptorsignalingpathwayviaJAK-STATregulationofcellgrowthregulationofsignaltransductionresponsetoestradiolregulationoftranscriptionbyRNApolymeraseIItranscriptioninitiationfromRNApolymeraseIIpromoterubiquitin-dependentproteincatabolicprocess
Vascular endothelial growth factor A
77
Vascular endothelial growth factor A
86
3.6
74
0.37
VEGFAVEGFAP15692P15692activationofproteinkinaseactivityangiogenesisarterymorphogenesisbasophilchemotaxisbranchinginvolvedinbloodvesselmorphogenesiscamera-typeeyemorphogenesiscardiacmusclecelldevelopmentcardiacvascularsmoothmusclecelldevelopmentcellmaturationcellmigrationinvolvedinsproutingangiogenesiscellularresponsetohypoxiacellularresponsetovascularendothelialgrowthfactorstimuluscellularstressresponsetoacidchemicalcommissuralneuronaxonguidancecoronaryarterymorphogenesiscoronaryveinmorphogenesisdopaminergicneurondifferentiationendothelialcellchemotaxisepithelialcelldifferentiationeyephotoreceptorcelldevelopmentheartmorphogenesisinuteroembryonicdevelopmentinductionofpositivechemotaxiskidneydevelopmentlactationlungdevelopmentlymphvesselmorphogenesismacrophagedifferentiationmammaryglandalveolusdevelopmentmesodermdevelopmentmonocytedifferentiationmotorneuronmigrationnegativeregulationofadherensjunctionorganizationnegativeregulationofapoptoticprocessnegativeregulationofblood-brainbarrierpermeabilitynegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofestablishmentofendothelialbarriernegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentoutflowtractmorphogenesisovarianfollicledevelopmentpositivechemotaxispositiveregulationofangiogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelladhesionpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellmigrationbyvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofcellproliferationbyVEGF-activatedplateletderivedgrowthfactorreceptorsignalingpathwaypositiveregulationofcold-inducedthermogenesispositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialtubeformationpositiveregulationofERK1andERK2cascadepositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofhistonedeacetylaseactivitypositiveregulationofleukocytemigrationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmastcellchemotaxispositiveregulationofneuroblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofpositivechemotaxispositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinkinaseCsignalingpositiveregulationofproteinkinaseDsignalingpositiveregulationofproteinlocalizationtoearlyendosomepositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorinternalizationpositiveregulationofretinalganglioncellaxonguidancepositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftrophoblastcellmigrationpositiveregulationofvascularpermeabilitypost-embryoniccamera-typeeyedevelopmentprimitiveerythrocytedifferentiationregulationofcellshaperegulationofnitricoxidemediatedsignaltransductionregulationofretinalganglioncellaxonguidanceregulationoftranscriptionbyRNApolymeraseIIresponsetohypoxiasproutingangiogenesissurfactanthomeostasistubeformationvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorreceptor-2signalingpathwayvascularendothelialgrowthfactorsignalingpathwayvascularwoundhealingvasculogenesisVEGF-activatedneuropilinsignalingpathway
Nitric oxide synthase, brain
331
Nitric oxide synthase, brain
331
3.7
84
0.32
NOS1NOS1P29476P29476agingargininecatabolicprocessbehavioralresponsetococainebraindevelopmentcellularresponsetoepinephrinestimuluscellularresponsetogrowthfactorstimuluscellularresponsetomechanicalstimulusestablishmentofproteinlocalizationfemalepregnancymulticellularorganismalresponsetostressmusclecontractionnegativeregulationofapoptoticprocessnegativeregulationofbloodpressurenegativeregulationofcalciumiontransportnegativeregulationofcellpopulationproliferationnegativeregulationofcytosoliccalciumionconcentrationnegativeregulationofheartcontractionnegativeregulationofhepaticstellatecellcontractionnegativeregulationofhydrolaseactivitynegativeregulationofinsulinsecretionnegativeregulationofironiontransmembranetransportnegativeregulationofneuronapoptoticprocessnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofpotassiumiontransportnegativeregulationofserotoninuptakenegativeregulationofvasoconstrictionnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionpeptidyl-cysteineS-nitrosylationpositiveregulationofadenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocesspositiveregulationofguanylatecyclaseactivitypositiveregulationofhistoneacetylationpositiveregulationoflong-termsynapticpotentiationpositiveregulationofneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsodiumiontransmembranetransportpositiveregulationoftheforceofheartcontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofheartcontractionregulationofneurogenesisregulationofsensoryperceptionofpainregulationofsodiumiontransportresponsetoactivityresponsetoestrogenresponsetoethanolresponsetoheatresponsetohormoneresponsetohypoxiaresponsetoleadionresponsetolipopolysaccharideresponsetonicotineresponsetonitricoxideresponsetonutrientlevelsresponsetoorganiccycliccompoundresponsetoorganonitrogencompoundresponsetopeptidehormoneresponsetovitaminEretrogradetrans-synapticsignalingbynitricoxidestriatedmusclecontractionsynapticsignalingbynitricoxidevasodilationxenobioticcatabolicprocess
Caspase-7
100
Caspase-7
246
3.6
67
0.41
CASP7CASP7P55210P55210apoptoticprocesscellularresponsetostaurosporineexecutionphaseofapoptosisextrinsicapoptoticsignalingpathwayfibroblastapoptoticprocessheartdevelopmentinflammatoryresponseintrinsicapoptoticsignalingpathwayneuronapoptoticprocesspositiveregulationofapoptoticprocessproteinprocessingproteolysisresponsetoUV
ADP-sugar pyrophosphatase
91
ADP-sugar pyrophosphatase
131
3.6
87
0.32
NUDT5NUDT5Q9UKK9Q9UKK9ATPgenerationfrompoly-ADP-D-ribosechromatinremodelingD-ribosecatabolicprocessnucleobase-containingsmallmoleculemetabolicprocessnucleosidephosphatemetabolicprocessnucleotidemetabolicprocessribonucleosidediphosphatecatabolicprocessribosephosphatemetabolicprocess
Nitric oxide synthase, inducible
110
Nitric oxide synthase, inducible
115
3.7
74
0.37
NOS2NOS2P35228P35228argininecatabolicprocesscellredoxhomeostasiscellularresponsetointerferon-gammacellularresponsetolipopolysaccharidecellularresponsetoxenobioticstimuluscircadianrhythmdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriuminflammatoryresponseinnateimmuneresponseinmucosanegativeregulationofbloodpressurenegativeregulationofgeneexpressionnegativeregulationofproteincatabolicprocessnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionpeptidyl-cysteineS-nitrosylationpositiveregulationofguanylatecyclaseactivitypositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofkillingofcellsofanotherorganismpositiveregulationofleukocytemediatedcytotoxicityprostaglandinsecretionregulationofcellpopulationproliferationregulationofcellularrespirationregulationofcytokineproductioninvolvedininflammatoryresponseregulationofinsulinsecretionresponsetobacteriumresponsetohormoneresponsetohypoxiaresponsetolipopolysaccharidesuperoxidemetabolicprocess
Nitric oxide synthase, endothelial
99
Nitric oxide synthase, endothelial
99
3.7
84
0.32
NOS3NOS3P29474P29474angiogenesisaorticvalvemorphogenesisargininecatabolicprocessbloodvesseldiametermaintenancebloodvesselremodelingcalciumiontransportcellredoxhomeostasisendocardialcushionmorphogenesisendothelialcellmigrationestablishmentoflocalizationincellhomeostasisofnumberofcellswithinatissueinuteroembryonicdevelopmentlipopolysaccharide-mediatedsignalingpathwaylungdevelopmentmitochondrionorganizationnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodpressurenegativeregulationofcalciumiontransportnegativeregulationofcellpopulationproliferationnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrolaseactivitynegativeregulationofmusclehyperplasianegativeregulationofplateletactivationnegativeregulationofpotassiumiontransportnegativeregulationofsmoothmusclecellproliferationnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionovulationfromovarianfolliclepositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofgeneexpressionpositiveregulationofguanylatecyclaseactivitypositiveregulationofNotchsignalingpathwaypotassiumiontransportpulmonaryvalvemorphogenesisregulationofbloodpressureregulationofnervoussystemprocessregulationofsodiumiontransportregulationofsystemicarterialbloodpressurebyendothelinregulationoftheforceofheartcontractionbychemicalsignalremovalofsuperoxideradicalsresponsetofluidshearstressresponsetoheatresponsetohormoneresponsetolipopolysaccharidesmoothmusclehyperplasiavasodilationventricularseptummorphogenesis
Nitric oxide synthase, endothelial
99
Nitric oxide synthase, endothelial
94
3.7
77
0.35
NOS3NOS3P29474P29474angiogenesisaorticvalvemorphogenesisargininecatabolicprocessbloodvesseldiametermaintenancebloodvesselremodelingcalciumiontransportcellredoxhomeostasisendocardialcushionmorphogenesisendothelialcellmigrationestablishmentoflocalizationincellhomeostasisofnumberofcellswithinatissueinuteroembryonicdevelopmentlipopolysaccharide-mediatedsignalingpathwaylungdevelopmentmitochondrionorganizationnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodpressurenegativeregulationofcalciumiontransportnegativeregulationofcellpopulationproliferationnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrolaseactivitynegativeregulationofmusclehyperplasianegativeregulationofplateletactivationnegativeregulationofpotassiumiontransportnegativeregulationofsmoothmusclecellproliferationnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionovulationfromovarianfolliclepositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofgeneexpressionpositiveregulationofguanylatecyclaseactivitypositiveregulationofNotchsignalingpathwaypotassiumiontransportpulmonaryvalvemorphogenesisregulationofbloodpressureregulationofnervoussystemprocessregulationofsodiumiontransportregulationofsystemicarterialbloodpressurebyendothelinregulationoftheforceofheartcontractionbychemicalsignalremovalofsuperoxideradicalsresponsetofluidshearstressresponsetoheatresponsetohormoneresponsetolipopolysaccharidesmoothmusclehyperplasiavasodilationventricularseptummorphogenesis
Hepatocyte growth factor
128
Hepatocyte growth factor
128
3.7
78
0.35
HGFHGFP14210P14210animalorganregenerationcellchemotaxiscellmorphogenesiscellularresponsetohepatocytegrowthfactorstimulusepithelialcellproliferationepithelialtomesenchymaltransitionhepatocytegrowthfactorreceptorsignalingpathwayliverdevelopmentmitoticcellcyclemyoblastproliferationnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-6productionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofreleaseofcytochromecfrommitochondriapositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofinterleukin-10productionpositiveregulationofMAPKcascadepositiveregulationofmyelinationpositiveregulationofneuronprojectionregenerationpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofbranchinginvolvedinsalivaryglandmorphogenesisbymesenchymal-epithelialsignalingregulationofp38MAPKcascaderegulationoftau-proteinkinaseactivityskeletalmusclecellproliferation
Xaa-Pro dipeptidase
158
Xaa-Pro dipeptidase
58
3.7
62
0.44
1
✔PEPDPEPDP12955P12955cellularaminoacidmetabolicprocesscollagencatabolicprocessproteolysis
Nitric oxide synthase, brain
331
Nitric oxide synthase, brain
331
3.7
70
0.39
NOS1NOS1P29475P29475argininecatabolicprocesscellredoxhomeostasiscellularresponsetogrowthfactorstimulusmulticellularorganismalresponsetostressmusclecontractionmyoblastfusionnegativeregulationofbloodpressurenegativeregulationofcalciumiontransportnegativeregulationofcalciumiontransportintocytosolnegativeregulationofhydrolaseactivitynegativeregulationofpotassiumiontransportnegativeregulationofserotoninuptakeneurotransmitterbiosyntheticprocessnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionpeptidyl-cysteineS-nitrosylationpositiveregulationofguanylatecyclaseactivitypositiveregulationofhistoneacetylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsodiumiontransmembranetransportpositiveregulationoftheforceofheartcontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofcalciumiontransmembranetransportviahighvoltage-gatedcalciumchannelregulationofcardiacmusclecontractionregulationofryanodine-sensitivecalcium-releasechannelactivityregulationofsodiumiontransportresponsetoheatresponsetohormoneresponsetohypoxiaresponsetolipopolysaccharideretrogradetrans-synapticsignalingbynitricoxidestriatedmusclecontractionvasodilationxenobioticcatabolicprocess
Fibrinogen alpha chain
184
Fibrinogen gamma chain
161
3.7
78
0.35
FIBAFIBGP02671P02679adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-1cellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
107
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
106
3.6
97
0.28
GPTGPTQ9H3H5Q9H3H5dolicholmetabolicprocessdolichol-linkedoligosaccharidebiosyntheticprocessproteinN-linkedglycosylationUDP-N-acetylglucosaminemetabolicprocess
Copper transport protein ATOX1
12
Copper transport protein ATOX1
15
3.7
65
0.42
ATOX1ATOX1O00244O00244cellularcopperionhomeostasiscopperiontransportresponsetooxidativestress
Gasdermin-D
299
Gasdermin-D
299
3.6
92
0.3
GSDMDGSDMDQ9D8T2Q9D8T2cellularresponsetoextracellularstimulusdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminflammatoryresponseinnateimmuneresponseporecomplexassemblyporeformationinmembraneofanotherorganismpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-1productionpositiveregulationofinterleukin-18productionproteinhomooligomerizationpyroptosis
Rab-3A-interacting protein
195
Rab-3A-interacting protein
195
3.6
54
0.51
RAB3IRAB3IQ96QF0Q96QF0ciliarybasalbody-plasmamembranedockingciliumassemblyexocytosisGolgitoplasmamembranetransportnegativeregulationoffilopodiumassemblyproteinlocalizationtoorganelleproteintargetingtomembrane
Fibrinogen beta chain
223
Fibrinogen gamma chain
161
3.6
72
0.38
FIBBFIBGP02675P02679adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Myosin-7
1748
Myosin-7
1748
3.6
93
0.3
MYH7MYH7P12883P12883adultheartdevelopmentATPmetabolicprocesscardiacmusclecontractioncardiacmusclehypertrophyinresponsetostressmusclecontractionmusclefilamentslidingregulationofheartrateregulationofslow-twitchskeletalmusclefibercontractionregulationoftheforceofheartcontractionregulationoftheforceofskeletalmusclecontractionsarcomereorganizationskeletalmusclecontractionstriatedmusclecontractiontransitionbetweenfastandslowfiberventricularcardiacmuscletissuemorphogenesis
Potassium voltage-gated channel subfamily D member 3
131
Potassium voltage-gated channel subfamily D member 3
110
3.7
60
0.46
KCND3KCND3Q62897Q62897cellularresponsetoBMPstimulusmembranerepolarizationmembranerepolarizationduringventricularcardiacmusclecellactionpotentialpotassiumionexportacrossplasmamembranepotassiumionimportacrossplasmamembranepotassiumiontransmembranetransportpotassiumiontransportproteinhomooligomerizationregulationofheartratebycardiacconductionregulationofiontransmembranetransportventricularcardiacmusclecellmembranerepolarization
Anaphase-promoting complex subunit 11
73
Anaphase-promoting complex subunit 11
51
3.7
52
0.53
APC11APC11Q9NYG5Q9NYG5anaphase-promotingcomplex-dependentcatabolicprocesscelldivisionmitoticcellcyclepositiveregulationofmitoticmetaphase/anaphasetransitionproteinK11-linkedubiquitinationproteinubiquitinationregulationofmeioticcellcycleregulationofmitoticcellcycleubiquitin-dependentproteincatabolicprocess
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
112
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
193
3.6
74
0.37
Q9TTF5Q9TTF5Q9TTF5Q9TTF5metabolicprocess
Germinal-center associated nuclear protein
1189
Transcription and mRNA export factor ENY2
50
3.7
79
0.35
GANPENY2O60318Q9NPA8mRNAexportfromnucleusnucleosomeorganizationpoly(A)+mRNAexportfromnucleusproteintransportsomatichypermutationofimmunoglobulingeneschromatinorganizationhistonedeubiquitinationhistoneH3acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationpositiveregulationoftranscriptionDNA-templatedregulationofDNArepairregulationofRNAsplicingregulationoftranscriptionbyRNApolymeraseIItranscriptionelongationfromRNApolymeraseIIpromoter
BAH and coiled-coil domain-containing protein 1
2582
BAH and coiled-coil domain-containing protein 1
2582
3.7
60
0.46
BAHC1BAHC1Q3UHR0Q3UHR0
Acetyl-CoA acetyltransferase, mitochondrial
142
Acetyl-CoA acetyltransferase, mitochondrial
142
3.7
74
0.37
THILTHILP24752P24752acetyl-CoAbiosyntheticprocessacetyl-CoAcatabolicprocessadiposetissuedevelopmentbraindevelopmentcoenzymeAbiosyntheticprocesscoenzymeAmetabolicprocessfattyacidbeta-oxidationisoleucinecatabolicprocessketonebodycatabolicprocessketonebodymetabolicprocessliverdevelopmentmetanephricproximalconvolutedtubuledevelopmentpropionyl-CoAbiosyntheticprocessresponsetohormoneresponsetoorganiccycliccompoundresponsetostarvation
Insulin
95
Insulin
31
9.3
50
0.22
INSINSP01317P01317estradiolsecretionfeedingbehaviorglucoseimportinresponsetoinsulinstimulusglucosemetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofappetitenegativeregulationoflactationnegativeregulationoflipidcatabolicprocesspositiveregulationofbloodcirculationpositiveregulationofcellmaturationpositiveregulationofgeneexpressionpositiveregulationofinsulinsecretionpositiveregulationoflactationpositiveregulationofmammaryglandepithelialcellproliferationpositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRhoproteinsignaltransductionproteinsecretionresponsetobutyrateresponsetofoodresponsetoglucoseresponsetogrowthhormoneresponsetoheatresponsetoL-arginineresponsetonutrientlevels
Fibrinogen beta chain
231
Fibrinogen gamma chain
165
9.3
74
0.15
FIBBFIBGP02675P02679adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Insulin
90
Insulin
31
9.2
56
0.19
INSINSP01317P01317estradiolsecretionfeedingbehaviorglucoseimportinresponsetoinsulinstimulusglucosemetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofappetitenegativeregulationoflactationnegativeregulationoflipidcatabolicprocesspositiveregulationofbloodcirculationpositiveregulationofcellmaturationpositiveregulationofgeneexpressionpositiveregulationofinsulinsecretionpositiveregulationoflactationpositiveregulationofmammaryglandepithelialcellproliferationpositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRhoproteinsignaltransductionproteinsecretionresponsetobutyrateresponsetofoodresponsetoglucoseresponsetogrowthhormoneresponsetoheatresponsetoL-arginineresponsetonutrientlevels
Pyruvate kinase PKLR
360
Pyruvate kinase PKLR
74
9.3
78
0.14
KPYRKPYRP30613P30613ATPbiosyntheticprocesscellularresponsetoepinephrinestimuluscellularresponsetoinsulinstimulusglycolyticprocesspyruvatebiosyntheticprocessresponsetoATPresponsetocAMPresponsetoglucoseresponsetoheatresponsetohypoxiaresponsetolithiumionresponsetonutrient
Caspase-3
47
Caspase-3
220
9.3
72
0.15
CASP3CASP3P42574P42574anteriorneuraltubeclosureapoptoticprocessapoptoticsignalingpathwayaxonalfasciculationBcellhomeostasiscellfatecommitmentcellularresponsetoDNAdamagestimuluscellularresponsetostaurosporineepithelialcellapoptoticprocesserythrocytedifferentiationexecutionphaseofapoptosisfibroblastapoptoticprocessglialcellapoptoticprocessheartdevelopmenthippocampusdevelopmentintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoosmoticstresskeratinocytedifferentiationlearningormemoryleukocyteapoptoticprocessluteolysisnegativeregulationofactivatedTcellproliferationnegativeregulationofapoptoticprocessnegativeregulationofBcellproliferationneuronapoptoticprocessneurondifferentiationneurotrophinTRKreceptorsignalingpathwayplateletformationpositiveregulationofamyloid-betaformationpositiveregulationofapoptoticDNAfragmentationpositiveregulationofapoptoticprocesspositiveregulationofneuronapoptoticprocessproteincatabolicprocessproteinprocessingproteolysisregulationofmacroautophagyregulationofproteinstabilityresponsetoaminoacidresponsetoantibioticresponsetocobaltionresponsetoestradiolresponsetoglucocorticoidresponsetoglucoseresponsetohydrogenperoxideresponsetohypoxiaresponsetolipopolysaccharideresponsetonicotineresponsetotumornecrosisfactorresponsetoUVresponsetoX-rayresponsetoxenobioticstimulussensoryperceptionofsoundstriatedmusclecelldifferentiationTcellhomeostasiswoundhealing
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
306
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
306
9.3
90
0.12
ODPBODPBP11177P11177acetyl-CoAbiosyntheticprocessfrompyruvateglucosemetabolicprocessmitochondrialacetyl-CoAbiosyntheticprocessfrompyruvatetricarboxylicacidcycle
Insulin
31
Insulin
96
9.3
52
0.21
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
Hemoglobin subunit alpha
105
Hemoglobin subunit beta
113
9.3
86
0.13
HBAHBBP69905P68871carbondioxidetransportcellularoxidantdetoxificationhydrogenperoxidecatabolicprocessnitricoxidetransportoxygentransportpositiveregulationofcelldeathresponsetohydrogenperoxideplateletaggregationpositiveregulationofnitricoxidebiosyntheticprocessregulationofbloodpressurerenalabsorption
Estrogen receptor
227
Estrogen receptor
240
9.3
66
0.16
ESR1ESR1P03372P03372androgenmetabolicprocessantralovarianfolliclegrowthcellularresponsetoestradiolstimuluscellularresponsetoestrogenstimuluschromatinremodelingepithelialcelldevelopmentepithelialcellproliferationinvolvedinmammaryglandductelongationfibroblastproliferationintracellularestrogenreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaymalegonaddevelopmentmammaryglandalveolusdevelopmentmammaryglandbranchinginvolvedinpregnancynegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofgeneexpressionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofmiRNAmaturationnegativeregulationoftranscriptionbyRNApolymeraseIIphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoffibroblastproliferationpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofphospholipaseCactivitypositiveregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprostateepithelialcordarborizationinvolvedinprostateglandularacinusmorphogenesisprostateepithelialcordelongationproteinlocalizationtochromatinregulationofbranchinginvolvedinprostateglandmorphogenesisregulationofepithelialcellapoptoticprocessregulationofinflammatoryresponseregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetoestradiolresponsetoestrogensignaltransductionstemcelldifferentiationtranscriptionbyRNApolymeraseIIuterusdevelopmentvaginadevelopment
Non-homologous end-joining factor 1
202
Non-homologous end-joining factor 1
148
9.3
62
0.17
NHEJ1NHEJ1Q9H9Q4Q9H9Q4BcelldifferentiationcentralnervoussystemdevelopmentDNAligationinvolvedinDNArepairdouble-strandbreakrepairvianonhomologousendjoiningimmunoglobulinV(D)JrecombinationpositiveregulationofligaseactivityresponsetoionizingradiationTcelldifferentiation
Cobalamin binding intrinsic factor
143
Cobalamin binding intrinsic factor
103
9.3
87
0.12
IFIFP27352P27352cobalaminmetabolicprocesscobalamintransportcobaltiontransport
Fibrinogen gamma-B chain
43
Fibrinogen gamma-B chain
43
9.3
91
0.12
FIBGFIBGP12799P12799bloodcoagulationfibrinclotformationcell-matrixadhesionplateletaggregationproteinpolymerization
Pyruvate kinase PKM
317
Pyruvate kinase PKM
31
9.3
82
0.13
KPYMKPYMP11974P11974positiveregulationofcytoplasmictranslationpositiveregulationofsproutingangiogenesis
Coagulation factor X
342
Coagulation factor X
164
9.3
72
0.15
FA10FA10P00742P00742bloodcoagulationbloodcoagulationcommonpathwaypositiveregulationofcellmigrationpositiveregulationofproteinkinaseBsignalingproteolysiszymogenactivation
Insulin
100
Insulin
31
9.2
50
0.22
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
Pyruvate kinase
66
Pyruvate kinase
352
9.2
78
0.14
Q16716Q16716Q16716Q16716
Fibrinogen gamma chain
49
Fibrinogen beta chain
95
9.2
78
0.14
FIBGFIBBP02679P02675bloodcoagulationfibrinclotformationcell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetointerleukin-6fibrinolysisnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofplateletaggregationplasminogenactivationplateletaggregationplateletmaturationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationproteinsecretionprotein-containingcomplexassemblyresponsetocalciumionadaptiveimmuneresponsecelladhesioncellularresponsetoleptinstimulusinductionofbacterialagglutinationinnateimmuneresponse
All-trans-retinol dehydrogenase [NAD(+)] ADH1B
287
All-trans-retinol dehydrogenase [NAD(+)] ADH1B
101
9.2
65
0.17
ADH1BADH1BP00325P00325ethanoloxidationretinoicacidmetabolicprocessretinoidmetabolicprocessretinolmetabolicprocess
Progesterone receptor
622
Progesterone receptor
609
9.2
71
0.15
PRGRPRGRP06401P06401cell-cellsignalingglandularepithelialcellmaturationintracellularsteroidhormonereceptorsignalingpathwaylungalveolusdevelopmentnegativeregulationofgeneexpressionovulationfromovarianfollicleparacrinesignalingpositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronereceptorsignalingpathwayregulationofepithelialcellproliferationregulationoftranscriptionbyRNApolymeraseIIsignaltransductiontertiarybranchinginvolvedinmammaryglandductmorphogenesis
Fibrinogen beta chain
227
Fibrinogen gamma chain
161
9.3
71
0.15
FIBBFIBGP02675P02679adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Fibrinogen alpha chain
55
Fibrinogen gamma chain
49
9.3
66
0.16
FIBAFIBGP02671P02679adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-1cellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Serine protease 1
48
Tissue factor pathway inhibitor 2
45
9.3
99
0.11
TRY1TFPI2P00760P48307digestionproteolysisbloodcoagulationcellularresponsetofluidshearstress
Vascular endothelial growth factor A
77
Vascular endothelial growth factor A
52
9.3
74
0.15
VEGFAVEGFAP15692P15692activationofproteinkinaseactivityangiogenesisarterymorphogenesisbasophilchemotaxisbranchinginvolvedinbloodvesselmorphogenesiscamera-typeeyemorphogenesiscardiacmusclecelldevelopmentcardiacvascularsmoothmusclecelldevelopmentcellmaturationcellmigrationinvolvedinsproutingangiogenesiscellularresponsetohypoxiacellularresponsetovascularendothelialgrowthfactorstimuluscellularstressresponsetoacidchemicalcommissuralneuronaxonguidancecoronaryarterymorphogenesiscoronaryveinmorphogenesisdopaminergicneurondifferentiationendothelialcellchemotaxisepithelialcelldifferentiationeyephotoreceptorcelldevelopmentheartmorphogenesisinuteroembryonicdevelopmentinductionofpositivechemotaxiskidneydevelopmentlactationlungdevelopmentlymphvesselmorphogenesismacrophagedifferentiationmammaryglandalveolusdevelopmentmesodermdevelopmentmonocytedifferentiationmotorneuronmigrationnegativeregulationofadherensjunctionorganizationnegativeregulationofapoptoticprocessnegativeregulationofblood-brainbarrierpermeabilitynegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofestablishmentofendothelialbarriernegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentoutflowtractmorphogenesisovarianfollicledevelopmentpositivechemotaxispositiveregulationofangiogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelladhesionpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellmigrationbyvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofcellproliferationbyVEGF-activatedplateletderivedgrowthfactorreceptorsignalingpathwaypositiveregulationofcold-inducedthermogenesispositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialtubeformationpositiveregulationofERK1andERK2cascadepositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofhistonedeacetylaseactivitypositiveregulationofleukocytemigrationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmastcellchemotaxispositiveregulationofneuroblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofpositivechemotaxispositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinkinaseCsignalingpositiveregulationofproteinkinaseDsignalingpositiveregulationofproteinlocalizationtoearlyendosomepositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorinternalizationpositiveregulationofretinalganglioncellaxonguidancepositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftrophoblastcellmigrationpositiveregulationofvascularpermeabilitypost-embryoniccamera-typeeyedevelopmentprimitiveerythrocytedifferentiationregulationofcellshaperegulationofnitricoxidemediatedsignaltransductionregulationofretinalganglioncellaxonguidanceregulationoftranscriptionbyRNApolymeraseIIresponsetohypoxiasproutingangiogenesissurfactanthomeostasistubeformationvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorreceptor-2signalingpathwayvascularendothelialgrowthfactorsignalingpathwayvascularwoundhealingvasculogenesisVEGF-activatedneuropilinsignalingpathway
Progesterone receptor
603
Progesterone receptor
603
9.3
62
0.17
PRGRPRGRP06401P06401cell-cellsignalingglandularepithelialcellmaturationintracellularsteroidhormonereceptorsignalingpathwaylungalveolusdevelopmentnegativeregulationofgeneexpressionovulationfromovarianfollicleparacrinesignalingpositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronereceptorsignalingpathwayregulationofepithelialcellproliferationregulationoftranscriptionbyRNApolymeraseIIsignaltransductiontertiarybranchinginvolvedinmammaryglandductmorphogenesis
Fibrinogen beta chain
227
Fibrinogen gamma chain
161
9.3
69
0.16
FIBBFIBGP02675Q53Y18adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Phenylethanolamine N-methyltransferase
48
Phenylethanolamine N-methyltransferase
131
9.2
68
0.16
PNMTPNMTP11086P11086catecholaminebiosyntheticprocessepinephrinebiosyntheticprocessmethylation
Fibrinogen alpha chain
55
Fibrinogen beta chain
106
9.2
80
0.14
FIBAFIBBP02671P02675adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncelladhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulus
Insulin
95
Insulin
31
9.2
58
0.19
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
4-trimethylaminobutyraldehyde dehydrogenase
443
4-trimethylaminobutyraldehyde dehydrogenase
484
9.2
96
0.11
AL9A1AL9A1P49189P49189carnitinebiosyntheticprocesscellularaldehydemetabolicprocesshormonemetabolicprocessneurotransmitterbiosyntheticprocessproteinhomotetramerization
Ketohexokinase
99
Ketohexokinase
98
9.2
91
0.12
KHKKHKP50053P50053fructosemetabolicprocessregulationofglycogenmetabolicprocessresponsetofructoseresponsetoglucoseresponsetoinsulinresponsetosucroseresponsetozincion
Peptidoglycan recognition protein 1
152
Peptidoglycan recognition protein 1
152
9.2
64
0.17
PGRP1PGRP1Q9GK12Q9GK12defenseresponsetobacteriuminnateimmuneresponsenegativeregulationofcytokineproductionpeptidoglycancatabolicprocess
Cellular tumor antigen p53
176
Cellular tumor antigen p53
176
9.2
66
0.16
P53P53P04637P04637autophagyBcelllineagecommitmentbonemarrowdevelopmentcardiacmusclecellapoptoticprocesscardiacseptummorphogenesiscellularresponsetoactinomycinDcellularresponsetoDNAdamagestimuluscellularresponsetogammaradiationcellularresponsetoglucosestarvationcellularresponsetohypoxiacellularresponsetoionizingradiationcellularresponsetoUVcellularresponsetoUV-CcellularresponsetoxenobioticstimuluscellularsenescencecerebellumdevelopmentchromatinassemblycircadianbehaviordeterminationofadultlifespanDNAdamageresponsesignaltransductionbyp53classmediatorDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestDNAdamageresponsesignaltransductionbyp53classmediatorresultingintranscriptionofp21classmediatordouble-strandbreakrepairembryonicorgandevelopmententrainmentofcircadianclockbyphotoperiodERoverloadresponsefibroblastproliferationgastrulationglialcellproliferationglucosecatabolicprocesstolactateviapyruvatehematopoieticprogenitorcelldifferentiationhematopoieticstemcelldifferentiationinuteroembryonicdevelopmentinterferon-gamma-mediatedsignalingpathwayintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwaybyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressintrinsicapoptoticsignalingpathwayinresponsetohypoxiamitochondrialDNArepairmitophagymitoticG1DNAdamagecheckpointsignalingmRNAtranscriptionmulticellularorganismgrowthnecroptoticprocessnegativeregulationofapoptoticprocessnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofDNAreplicationnegativeregulationoffibroblastproliferationnegativeregulationofG1toG0transitionnegativeregulationofglialcellproliferationnegativeregulationofglucosecatabolicprocesstolactateviapyruvatenegativeregulationofhelicaseactivitynegativeregulationofmiRNAmaturationnegativeregulationofmitophagynegativeregulationofneuroblastproliferationnegativeregulationofpentose-phosphateshuntnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofstemcellproliferationnegativeregulationoftelomeraseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayneuroblastproliferationneuronapoptoticprocessnucleotide-excisionrepairoligodendrocyteapoptoticprocessoxidativestress-inducedprematuresenescencepositiveregulationofapoptoticprocesspositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcellularsenescencepositiveregulationofexecutionphaseofapoptosispositiveregulationofgeneexpressionpositiveregulationofhistonedeacetylationpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofmitochondrialmembranepermeabilitypositiveregulationofneuronapoptoticprocesspositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofprogrammednecroticcelldeathpositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofreleaseofcytochromecfrommitochondriapositiveregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblypositiveregulationofthymocyteapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoendoplasmicreticulumstresspositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetostresspositiveregulationoftranscriptionDNA-templatedproteinimportintonucleusproteinlocalizationproteinstabilizationproteintetramerizationprotein-containingcomplexassemblyRasproteinsignaltransductionreactiveoxygenspeciesmetabolicprocessregulationofapoptoticprocessregulationofcellcycleregulationofcellcycleG2/MphasetransitionregulationofDNAdamageresponsesignaltransductionbyp53classmediatorregulationoffibroblastapoptoticprocessregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorregulationofmitochondrialmembranepermeabilityinvolvedinapoptoticprocessregulationoftissueremodelingregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoDNAdamageregulationoftranscriptionDNA-templatedreleaseofcytochromecfrommitochondriareplicativesenescenceresponsetoantibioticresponsetogammaradiationresponsetoischemiaresponsetosaltstressresponsetoX-rayrRNAtranscriptionsignaltransductionbyp53classmediatorsomitogenesisstemcellproliferationTcelldifferentiationinthymusTcelllineagecommitmentTcellproliferationinvolvedinimmuneresponsethymocyteapoptoticprocesstransforminggrowthfactorbetareceptorsignalingpathwaytumornecrosisfactor-mediatedsignalingpathwayviralprocess
Glycoprotein hormones alpha chain
56
Follitropin subunit beta
50
9.2
76
0.14
GLHAFSHBP01215P01225follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationfemalegametegenerationfemalepregnancypositiveregulationofboneresorptionpositiveregulationofgeneexpressionprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationSertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Hemoglobin subunit alpha
104
Hemoglobin subunit beta-A/B
112
9.2
86
0.13
HBAHBBP07405P07412cellularoxidantdetoxificationhydrogenperoxidecatabolicprocess
Glucocorticoid receptor
463
Glucocorticoid receptor
476
9.2
67
0.16
GCRGCRP04150P04150adrenalglanddevelopmentapoptoticprocesscellcyclecelldivisioncellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinorganizationchromosomesegregationglucocorticoidmetabolicprocessintracellularsteroidhormonereceptorsignalingpathwaymammaryglandductmorphogenesismaternalbehaviornegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedsignaltransduction
Dihydrolipoyl dehydrogenase, mitochondrial
484
Dihydrolipoyl dehydrogenase, mitochondrial
388
9.2
82
0.13
DLDHDLDHP09622P09622acetyl-CoAbiosyntheticprocessfrompyruvatebranched-chainaminoacidcatabolicprocesscellredoxhomeostasisgastrulationhistonesuccinylationmitochondrialacetyl-CoAbiosyntheticprocessfrompyruvatemitochondrialelectrontransportNADHtoubiquinoneproteolysisregulationofmembranepotentialspermcapacitation
Gamma-crystallin S
25
Gamma-crystallin S
23
9.3
73
0.15
CRYGSCRYGSO35486O35486lensdevelopmentincamera-typeeyemorphogenesisofanepitheliumvisualperception
Glycoprotein hormones alpha chain
56
Follitropin subunit beta
50
9.3
82
0.13
Q96QJ4FSHBQ96QJ4P01225femalegametegenerationfemalepregnancyfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwaypositiveregulationofboneresorptionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationregulationofsignalingreceptoractivitySertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Pyruvate kinase PKM
31
Pyruvate kinase PKM
317
9.2
80
0.14
KPYMKPYMP14618P14618canonicalglycolysiscellularresponsetoinsulinstimulusglycolyticprocesspositiveregulationofcytoplasmictranslationpositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIprogrammedcelldeath
S-adenosylmethionine decarboxylase proenzyme
49
S-adenosylmethionine decarboxylase proenzyme
82
9.2
72
0.15
DCAMDCAMP17707P17707polyaminemetabolicprocessS-adenosylmethioninaminebiosyntheticprocessS-adenosylmethioninemetabolicprocessspermidinebiosyntheticprocesssperminebiosyntheticprocess
Beta-nerve growth factor
189
Beta-nerve growth factor
231
9.2
88
0.12
NGFNGFP01139P01139activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessadultlocomotorybehavioraxonextensioncircadianrhythmextrinsicapoptoticsignalingpathwayinabsenceofligandextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsmemorymodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnegativeregulationoftypeBpancreaticcellapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwayneuronapoptoticprocessneuronprojectiondevelopmentneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofaxonextensionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofcollateralsproutingpositiveregulationofDNAbindingpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofneurondifferentiationpositiveregulationofneuronmaturationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofneurotrophinTRKreceptorsignalingpathwaypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinautophosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinphosphorylationpositiveregulationofproteinubiquitinationpositiveregulationofRasproteinsignaltransductionpositiveregulationofstemcellproliferationproteinphosphorylationregulationofneurondifferentiationregulationofneurotransmittersecretionregulationofreleaseofsequesteredcalciumionintocytosolsensoryperceptionofpaintransmembranereceptorproteintyrosinekinasesignalingpathway
Potassium voltage-gated channel subfamily D member 3
110
Potassium voltage-gated channel subfamily D member 3
132
3.6
64
0.43
KCND3KCND3Q62897Q62897cellularresponsetoBMPstimulusmembranerepolarizationmembranerepolarizationduringventricularcardiacmusclecellactionpotentialpotassiumionexportacrossplasmamembranepotassiumionimportacrossplasmamembranepotassiumiontransmembranetransportpotassiumiontransportproteinhomooligomerizationregulationofheartratebycardiacconductionregulationofiontransmembranetransportventricularcardiacmusclecellmembranerepolarization
Mast/stem cell growth factor receptor Kit
674
Mast/stem cell growth factor receptor Kit
674
3.6
65
0.42
KITKITP10721P10721actincytoskeletonreorganizationBcelldifferentiationcellchemotaxiscellularresponsetothyroidhormonestimuluscytokine-mediatedsignalingpathwaydetectionofmechanicalstimulusinvolvedinsensoryperceptionofsounddigestivetractdevelopmentectopicgermcellprogrammedcelldeathembryonichemopoiesisepithelialcellproliferationerythrocytedifferentiationerythropoietin-mediatedsignalingpathwayFcreceptorsignalingpathwaygermcellmigrationglycosphingolipidmetabolicprocesshematopoieticprogenitorcelldifferentiationhematopoieticstemcellmigrationhemopoiesisimmatureBcelldifferentiationinflammatoryresponseintracellularsignaltransductionKitsignalingpathwaylamellipodiumassemblylymphoidprogenitorcelldifferentiationmalegonaddevelopmentmastcellchemotaxismastcelldegranulationmastcelldifferentiationmastcellproliferationmegakaryocytedevelopmentmelanocyteadhesionmelanocytedifferentiationmelanocytemigrationmyeloidprogenitorcelldifferentiationnegativeregulationofdevelopmentalprocessnegativeregulationofprogrammedcelldeathnegativeregulationofreproductiveprocessovarianfollicledevelopmentpigmentationpositiveregulationofcellmigrationpositiveregulationofcolonsmoothmusclecontractionpositiveregulationofdendriticcellcytokineproductionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofkinaseactivitypositiveregulationoflong-termneuronalsynapticplasticitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmastcellcytokineproductionpositiveregulationofmastcellproliferationpositiveregulationofNotchsignalingpathwaypositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphospholipaseCactivitypositiveregulationofpseudopodiumassemblypositiveregulationofpyloricantrumsmoothmusclecontractionpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmallintestinesmoothmusclecontractionpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecelldifferentiationproteinautophosphorylationregulationofbileacidmetabolicprocessregulationofcellpopulationproliferationregulationofcellshaperesponsetocadmiumionsignaltransductionsomaticstemcelldivisionsomaticstemcellpopulationmaintenancespermatiddevelopmentspermatogenesisstemcelldifferentiationstemcellpopulationmaintenanceTcelldifferentiationtonguedevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathwayvisuallearning
E3 ubiquitin-protein ligase TRIM7
390
E3 ubiquitin-protein ligase TRIM7
455
9.3
81
0.13
TRIM7TRIM7Q9C029Q9C029proteinubiquitination
Tumor necrosis factor receptor superfamily member 9
120
Tumor necrosis factor receptor superfamily member 9
121
9.3
77
0.14
TNR9TNR9Q07011Q07011apoptoticprocessnegativeregulationofcellpopulationproliferationregulationofcellpopulationproliferationregulationofimmatureTcellproliferationinthymus
Hematopoietic prostaglandin D synthase
101
Hematopoietic prostaglandin D synthase
101
9.3
53
0.2
HPGDSHPGDSO60760O60760glutathionemetabolicprocesslocomotorybehaviornegativeregulationofmalegermcellproliferationprostaglandinbiosyntheticprocessprostaglandinmetabolicprocesssignaltransduction
Peptidoglycan recognition protein 1
152
Peptidoglycan recognition protein 1
28
9.3
68
0.16
PGRP1PGRP1Q9GK12Q9GK12defenseresponsetobacteriuminnateimmuneresponsenegativeregulationofcytokineproductionpeptidoglycancatabolicprocess
Group 10 secretory phospholipase A2
125
Group 10 secretory phospholipase A2
100
9.2
70
0.15
PA2GXPA2GXO15496O15496arachidonicacidmetabolicprocessarachidonicacidsecretionaxonguidancecellularresponsetoleukemiainhibitoryfactorcholesterolhomeostasisdefenseresponsetoviruserythrocytematurationfertilizationhairfolliclemorphogenesisintestinalstemcellhomeostasislow-densitylipoproteinparticleremodelinglysophospholipidtransportmacrophageactivationnegativeregulationofcholesteroleffluxnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofinflammatoryresponsephosphatidicacidmetabolicprocessphosphatidylcholinecatabolicprocessphosphatidylcholinemetabolicprocessphosphatidylethanolaminemetabolicprocessphosphatidylglycerolmetabolicprocessphosphatidylserinemetabolicprocessphospholipidmetabolicprocessplateletactivatingfactorcatabolicprocesspositiveregulationofacrosomereactionpositiveregulationofarachidonicacidsecretionpositiveregulationoflipidstoragepositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofprostaglandinsecretionpositiveregulationofproteinmetabolicprocessproductionofmolecularmediatorinvolvedininflammatoryresponseprostaglandinbiosyntheticprocessregulationofmacrophageactivation
Trypsin-3
105
Pancreatic trypsin inhibitor
49
9.2
95
0.11
TRY3BPT1P35030P00974antimicrobialhumoralresponsedigestionendothelialcellmigrationproteolysiszymogenactivationnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Fibrinogen beta chain
231
Fibrinogen gamma chain
165
9.2
76
0.14
FIBBFIBGP02675Q53Y18adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Baculoviral IAP repeat-containing protein 7
127
Baculoviral IAP repeat-containing protein 7
127
9.3
93
0.12
BIRC7BIRC7Q96CA5Q96CA5lensdevelopmentincamera-typeeyenegativeregulationofapoptoticprocessnegativeregulationoftumornecrosisfactor-mediatedsignalingpathwaypositiveregulationofJNKcascadepositiveregulationofproteinubiquitinationproteinubiquitinationregulationofapoptoticprocessregulationofcellcycleregulationofcellpopulationproliferationregulationofcellularproteinmetabolicprocessregulationofnaturalkillercellapoptoticprocess
Resistin-like beta
102
Resistin-like beta
49
9.3
73
0.15
RETNBRETNBQ99P86Q99P86responsetobacterium
Nitric-oxide synthase (NADPH)
99
Nitric-oxide synthase (NADPH)
99
3.6
89
0.31
A0S0A6A0S0A6A0S0A6A0S0A6nitricoxidebiosyntheticprocess
C-C motif chemokine 1
33
C-C motif chemokine 1
33
3.7
74
0.36
CCL1CCL1P22362P22362antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiseosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-17productionpositiveregulationofmonocytechemotaxissignaltransductionviralprocess
Thymidylate synthase
180
Thymidylate synthase
180
3.7
88
0.31
TYSYTYSYP04818P04818agingcartilagedevelopmentcircadianrhythmdevelopmentalgrowthDNAbiosyntheticprocessdTMPbiosyntheticprocessdTTPbiosyntheticprocessintestinalepithelialcellmaturationliverregenerationmethylationnegativeregulationoftranslationresponsetocytokineresponsetoethanolresponsetofolicacidresponsetoglucocorticoidresponsetoorganophosphorusresponsetoprogesteroneresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulustetrahydrofolateinterconversionuracilmetabolicprocess
Transducin-like enhancer protein 1
89
Transducin-like enhancer protein 1
89
3.7
75
0.36
TLE1TLE1Q04724Q04724animalorganmorphogenesisnegativeregulationofanoikisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationoftranscriptionDNA-templatednegativeregulationofWntsignalingpathwaypositiveregulationofgeneexpressionsignaltransductionWntsignalingpathway
Tropomyosin alpha-1 chain
190
Tropomyosin alpha-1 chain
190
3.6
50
0.55
1
✔TPM1TPM1P42639P42639actinfilamentorganizationcardiacmusclecontractionmusclecontraction
Copper transport protein ATOX1
12
Copper transport protein ATOX1
12
3.6
49
0.56
ATOX1ATOX1O00244O00244cellularcopperionhomeostasiscopperiontransportresponsetooxidativestress
Fibrinogen alpha chain
184
Fibrinogen gamma chain
161
3.6
74
0.37
FIBAFIBGP02671Q53Y18adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-1cellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
General transcription factor IIH subunit 3
142
General transcription factor IIH subunit 2
371
3.7
84
0.32
TF2H3TF2H2Q13889Q13888DNArepairnucleotide-excisionrepairphosphorylationofRNApolymeraseIIC-terminaldomaintranscriptionbyRNApolymeraseIIGprotein-coupledreceptorinternalizationpositiveregulationofDNAhelicaseactivityregulationoftranscriptionbyRNApolymeraseIIresponsetoUVtranscriptioninitiationfromRNApolymeraseIIpromoter
TNF receptor-associated factor 2
303
TNF receptor-associated factor 2
303
3.7
70
0.38
TRAF2TRAF2Q12933Q12933activationofNF-kappaB-inducingkinaseactivitycellularresponsetonitricoxideinterleukin-17-mediatedsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressmRNAstabilizationnegativeregulationofglialcellapoptoticprocessnegativeregulationofneurondeathpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofI-kappaBphosphorylationpositiveregulationofinterleukin-2productionpositiveregulationofJNKcascadepositiveregulationofJUNkinaseactivitypositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofTcellcytokineproductionpositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayprogrammednecroticcelldeathproteinautoubiquitinationproteincatabolicprocessproteinK63-linkedubiquitinationprotein-containingcomplexassemblyregulationofapoptoticprocessregulationofI-kappaBkinase/NF-kappaBsignalingregulationofimmunoglobulinproductionregulationofprotein-containingcomplexassemblyresponsetoendoplasmicreticulumstresssignaltransductionsignaltransductioninvolvedinregulationofgeneexpressiontumornecrosisfactor-mediatedsignalingpathway
F-box only protein 11
868
F-box only protein 11
888
3.7
60
0.45
FBX11FBX11Q86XK2Q86XK2proteinmodificationprocessproteinubiquitinationregulationofapoptoticprocesssensoryperceptionofsoundubiquitin-dependentproteincatabolicprocess
Nitric-oxide synthase (NADPH)
94
Nitric-oxide synthase (NADPH)
99
3.7
76
0.35
A0S0A6A0S0A6A0S0A6A0S0A6nitricoxidebiosyntheticprocess
Transducin-like enhancer protein 1
47
Transducin-like enhancer protein 1
47
3.7
52
0.52
TLE1TLE1Q04724Q04724animalorganmorphogenesisnegativeregulationofanoikisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationoftranscriptionDNA-templatednegativeregulationofWntsignalingpathwaypositiveregulationofgeneexpressionsignaltransductionWntsignalingpathway
Urokinase plasminogen activator surface receptor
46
Urokinase plasminogen activator surface receptor
98
3.7
64
0.42
UPARUPARQ03405Q03405bloodcoagulationchemotaxisnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaynegativeregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofDNAbindingpositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofhomotypiccell-celladhesionpositiveregulationofproteinphosphorylationpositiveregulationofreleaseofcytochromecfrommitochondriaregulationofcelladhesionregulationoffibrinolysisregulationofplasminogenactivationregulationofproteolysissignaltransductionurokinaseplasminogenactivatorsignalingpathway
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
201
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
119
3.7
83
0.32
CD38CD38P28907P28907apoptoticsignalingpathwayarterysmoothmusclecontractionBcellproliferationBcellreceptorsignalingpathwayfemalepregnancylong-termsynapticdepressionNADmetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofboneresorptionnegativeregulationofneuronprojectiondevelopmentnegativeregulationoftranscriptionDNA-templatedpositiveregulationofBcellproliferationpositiveregulationofcellgrowthpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofinsulinsecretionpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvasoconstrictionresponsetoestradiolresponsetohydroperoxideresponsetohypoxiaresponsetointerleukin-1responsetoprogesteroneresponsetoretinoicacidresponsetoxenobioticstimulussignaltransduction
ATP-binding cassette sub-family G member 8
425
ATP-binding cassette sub-family G member 8
425
3.6
60
0.46
ABCG8ABCG8Q9H221Q9H221bileacidsignalingpathwaycholesteroleffluxcholesterolhomeostasisintestinalcholesterolabsorptionnegativeregulationofintestinalcholesterolabsorptionnegativeregulationofintestinalphytosterolabsorptionphospholipidtransportresponsetomuscleactivityresponsetonutrientresponsetoxenobioticstimulussteroltransporttransmembranetransporttriglyceridehomeostasis
Fibrinogen beta chain
223
Fibrinogen gamma chain
161
3.6
74
0.38
FIBBFIBGP02675Q53Y18adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Whirlin
866
Whirlin
866
3.6
74
0.38
WHRNWHRNQ80VW5Q80VW5auditoryreceptorcellstereociliumorganizationcerebellarPurkinjecelllayerformationdetectionofmechanicalstimulusinvolvedinsensoryperceptionofsoundestablishmentoflocalizationincellestablishmentofproteinlocalizationinnerearreceptorcelldifferentiationinnerearreceptorcellstereociliumorganizationparanodaljunctionmaintenancepositiveregulationofgeneexpressionretinahomeostasissensoryperceptionoflightstimulussensoryperceptionofsound
F-box only protein 11
872
F-box only protein 11
890
3.6
63
0.44
FBX11FBX11Q86XK2Q86XK2proteinmodificationprocessproteinubiquitinationregulationofapoptoticprocesssensoryperceptionofsoundubiquitin-dependentproteincatabolicprocess
Malonyl-CoA decarboxylase, mitochondrial
206
Malonyl-CoA decarboxylase, mitochondrial
206
3.6
66
0.42
1
✔DCMCDCMCO95822O95822acetyl-CoAbiosyntheticprocessacyl-CoAmetabolicprocessfattyacidbiosyntheticprocessfattyacidoxidationmalonyl-CoAcatabolicprocesspositiveregulationoffattyacidoxidationregulationoffattyacidbeta-oxidationregulationofglucosemetabolicprocessresponsetoischemia
Complement C3
873
Complement C3
1513
3.6
76
0.37
CO3CO3P01024P01024amyloid-betaclearancecellsurfacereceptorsignalingpathwayinvolvedincell-cellsignalingcomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitycomplement-mediatedsynapsepruningfattyacidmetabolicprocessGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseneuronremodelingopsonizationoviductepitheliumdevelopmentpositiveregulationofactivationofmembraneattackcomplexpositiveregulationofangiogenesispositiveregulationofapoptoticcellclearancepositiveregulationofapoptoticprocessinanotherorganismpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofglucosetransmembranetransportpositiveregulationofimmuneresponsepositiveregulationoflipidstoragepositiveregulationofopsonizationpositiveregulationofphagocytosispositiveregulationofphagocytosisengulfmentpositiveregulationofproteinphosphorylationpositiveregulationofreceptor-mediatedendocytosispositiveregulationoftypeIIahypersensitivitypositiveregulationofvascularendothelialgrowthfactorproductionproteolysisregulationofcomplementactivationregulationofcomplementactivationalternativepathwayregulationoftriglyceridebiosyntheticprocessresponsetobacteriumsignaltransductionvertebrateeye-specificpatterning
Plexin-B2
1510
Plexin-B2
1510
3.6
44
0.63
PLXB2PLXB2B2RXS4B2RXS4braindevelopmentexcitatorysynapseassemblyhomophiliccelladhesionviaplasmamembraneadhesionmoleculesnegativeregulationofcelladhesionneuraltubeclosureneuroblastproliferationpositiveregulationofaxonogenesispositiveregulationofneuronprojectiondevelopmentpositiveregulationoftranslationregulationofcellmigrationregulationofcellshaperegulationofGTPaseactivityregulationofneuronmigrationregulationofproteinphosphorylationsemaphorin-plexinsignalingpathwaysemaphorin-plexinsignalingpathwayinvolvedinaxonguidance
Cytidine deaminase
65
Cytidine deaminase
59
3.6
77
0.36
CDDCDDP32320P32320cellsurfacereceptorsignalingpathwaycellularresponsetoexternalbioticstimuluscytidinedeaminationcytosinemetabolicprocessnegativeregulationofcellgrowthnegativeregulationofnucleotidemetabolicprocesspyrimidine-containingcompoundsalvageresponsetocycloheximideUMPsalvage
Immunoglobulin heavy constant epsilon
209
Immunoglobulin heavy constant epsilon
121
3.6
76
0.36
IGHEIGHEP01854P01854adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Beta-adrenergic receptor kinase 1
120
Beta-adrenergic receptor kinase 1
120
3.6
42
0.66
ARBK1ARBK1P21146P21146cardiacmusclecontractiondesensitizationofGprotein-coupledreceptorsignalingpathwayGprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledreceptorinternalizationGprotein-coupledreceptorsignalingpathwayheartdevelopmentintracellularproteintransportnegativeregulationofrelaxationofsmoothmusclenegativeregulationofstriatedmusclecontractionnegativeregulationoftheforceofheartcontractionbychemicalsignalpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofproteinlocalizationtociliumpositiveregulationofsmoothenedsignalingpathwayproteinphosphorylationregulationofsignaltransductionregulationoftheforceofheartcontractiontachykininreceptorsignalingpathwayviralentryintohostcellviralgenomereplication
Nitric oxide synthase, inducible
115
Nitric oxide synthase, inducible
115
3.6
83
0.33
NOS2NOS2P35228P35228argininecatabolicprocesscellredoxhomeostasiscellularresponsetointerferon-gammacellularresponsetolipopolysaccharidecellularresponsetoxenobioticstimuluscircadianrhythmdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriuminflammatoryresponseinnateimmuneresponseinmucosanegativeregulationofbloodpressurenegativeregulationofgeneexpressionnegativeregulationofproteincatabolicprocessnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionpeptidyl-cysteineS-nitrosylationpositiveregulationofguanylatecyclaseactivitypositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofkillingofcellsofanotherorganismpositiveregulationofleukocytemediatedcytotoxicityprostaglandinsecretionregulationofcellpopulationproliferationregulationofcellularrespirationregulationofcytokineproductioninvolvedininflammatoryresponseregulationofinsulinsecretionresponsetobacteriumresponsetohormoneresponsetohypoxiaresponsetolipopolysaccharidesuperoxidemetabolicprocess
Serine protease 1
48
Pancreatic trypsin inhibitor
49
9.2
97
0.11
TRY1BPT1P00760P00974digestionproteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Glycoprotein hormones alpha chain
111
Follitropin subunit beta
105
9.2
76
0.14
Q96QJ4FSHBQ96QJ4P01225femalegametegenerationfemalepregnancyfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwaypositiveregulationofboneresorptionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationregulationofsignalingreceptoractivitySertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Cyclin-dependent kinase 5
53
Cyclin-dependent kinase 5 activator 1
261
9.2
82
0.13
CDK5CD5R1Q00535Q15078axonextensionaxonogenesisbehavioralresponsetococainecalciumionimportcelldivisioncell-matrixadhesioncellularresponsetoamyloid-betacentralnervoussystemneurondevelopmentcerebellarcortexformationchemicalsynaptictransmissioncorpuscallosumdevelopmentcorticalactincytoskeletonorganizationdendritemorphogenesisexcitatorypostsynapticpotentialhippocampusdevelopmenthistonephosphorylationintracellularproteintransportlayerformationincerebralcortexmicrotubulecytoskeletonorganizationmitochondrionorganizationmotorneuronaxonguidancenegativeregulationofaxonextensionnegativeregulationofcellcyclenegativeregulationofneurondeathnegativeregulationofproteinexportfromnucleusnegativeregulationofproteinubiquitinationnegativeregulationofproteolysisnegativeregulationofsynapticplasticitynegativeregulationoftranscriptionDNA-templatedneuronapoptoticprocessneurondifferentiationneuronmigrationneuronprojectiondevelopmentnucleocytoplasmictransportoligodendrocytedifferentiationpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationphosphorylationpositiveregulationofactincytoskeletonreorganizationpositiveregulationofcalciumion-dependentexocytosispositiveregulationofglialcellapoptoticprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofproteinbindingpositiveregulationofproteinkinaseactivitypositiveregulationofproteintargetingtomembranepositiveregulationofvoltage-gatedcalciumchannelactivityproteinautophosphorylationproteinlocalizationtosynapseproteinphosphorylationreceptorcatabolicprocessreceptorclusteringregulationofapoptoticprocessregulationofcellcycleregulationofcellmigrationregulationofdendriticspinemorphogenesisregulationofmacroautophagyregulationofproteinlocalizationtoplasmamembraneregulationofsynapticplasticityregulationofsynaptictransmissionglutamatergicregulationofsynapticvesiclerecyclingregulationoftranscriptioninvolvedinG1/StransitionofmitoticcellcycleresponsetowoundingrhythmicprocessSchwanncelldevelopmentsensoryperceptionofpainserinephosphorylationofSTATproteinskeletalmuscletissuedevelopmentsynapseassemblysynapsepruningsynaptictransmissiondopaminergicsynaptictransmissionglutamatergicsynapticvesicleendocytosissynapticvesicleexocytosissynapticvesicletransportvisuallearningaxonguidanceaxonalfasciculationbraindevelopmentcerebellumdevelopmentembryodevelopmentendinginbirthoregghatchingephrinreceptorsignalingpathwayGprotein-coupledacetylcholinereceptorsignalingpathwayG1toG0transitioninvolvedincelldifferentiationionotropicglutamatereceptorsignalingpathwayneuroncell-celladhesionpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofmicrotubulepolymerizationpositiveregulationofsignalingreceptoractivityregulationofactincytoskeletonorganizationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofneurondifferentiationregulationofsynapticvesiclecyclesuperiorolivarynucleusmaturation
Kunitz-type protease inhibitor 1
283
Suppressor of tumorigenicity 14 protein
641
9.2
89
0.12
SPIT1ST14O43278Q9Y5Y6branchinginvolvedinlabyrinthinelayermorphogenesiscellularresponsetoBMPstimulusepidermisdevelopmentepitheliumdevelopmentextracellularmatrixorganizationnegativeregulationofneuralprecursorcellproliferationneuraltubeclosureplacentabloodvesseldevelopmentpositiveregulationofglialcelldifferentiationepithelialcellmorphogenesisinvolvedinplacentalbranchingkeratinocytedifferentiationproteincatabolicprocessproteolysis
ATP-dependent RNA helicase DHX58
559
ATP-dependent RNA helicase DHX58
556
9.2
70
0.15
DHX58DHX58Q96C10Q96C10cytoplasmicpatternrecognitionreceptorsignalingpathwayinresponsetovirusinnateimmuneresponsenegativeregulationofinnateimmuneresponsenegativeregulationofMDA-5signalingpathwaynegativeregulationofRIG-IsignalingpathwaynegativeregulationoftypeIinterferonproductionpositiveregulationofinterferon-betaproductionpositiveregulationofMDA-5signalingpathwaypositiveregulationofRIG-IsignalingpathwaypositiveregulationoftypeIinterferonproductionregulationofinnateimmuneresponseresponsetobacteriumresponsetovirus
Complement C3
873
Complement C3
1506
9.2
58
0.19
CO3CO3P01024P01024amyloid-betaclearancecellsurfacereceptorsignalingpathwayinvolvedincell-cellsignalingcomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitycomplement-mediatedsynapsepruningfattyacidmetabolicprocessGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseneuronremodelingopsonizationoviductepitheliumdevelopmentpositiveregulationofactivationofmembraneattackcomplexpositiveregulationofangiogenesispositiveregulationofapoptoticcellclearancepositiveregulationofapoptoticprocessinanotherorganismpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofglucosetransmembranetransportpositiveregulationofimmuneresponsepositiveregulationoflipidstoragepositiveregulationofopsonizationpositiveregulationofphagocytosispositiveregulationofphagocytosisengulfmentpositiveregulationofproteinphosphorylationpositiveregulationofreceptor-mediatedendocytosispositiveregulationoftypeIIahypersensitivitypositiveregulationofvascularendothelialgrowthfactorproductionproteolysisregulationofcomplementactivationregulationofcomplementactivationalternativepathwayregulationoftriglyceridebiosyntheticprocessresponsetobacteriumsignaltransductionvertebrateeye-specificpatterning
Elongin-C
112
von Hippel-Lindau disease tumor suppressor
162
9.2
nan
nan
ELOCVHLQ15369P40337proteinubiquitinationregulationoftranscriptionbyRNApolymeraseIItranscriptioninitiationfromRNApolymeraseIIpromoterubiquitin-dependentproteincatabolicprocesscellmorphogenesisnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationnegativeregulationofgeneexpressionnegativeregulationofreceptorsignalingpathwayviaJAK-STATnegativeregulationoftranscriptionelongationfromRNApolymeraseIIpromoternegativeregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationofcelldifferentiationpositiveregulationoftranscriptionDNA-templatedproteinstabilizationproteolysisregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiaregulationoftranscriptionDNA-templated
E3 ubiquitin-protein ligase Mdm2
478
E3 ubiquitin-protein ligase Mdm2
461
9.2
81
0.13
MDM2MDM2Q7YRZ8Q7YRZ8apoptoticprocessnegativeregulationofapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedproteinubiquitinationregulationofbiologicalqualityregulationofcellcycleregulationoftranscriptionbyRNApolymeraseII
Mucin-2
1117
Mucin-2
1088
9.2
75
0.14
MUC2MUC2Q02817Q02817maintenanceofgastrointestinalepithelium
Protein fem-1 homolog C
357
Protein fem-1 homolog C
357
9.2
72
0.15
FEM1CFEM1CQ96JP0Q96JP0proteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitinationubiquitin-dependentproteincatabolicprocessubiquitin-dependentproteincatabolicprocessviatheC-enddegronrulepathway
Transforming growth factor beta-1 proprotein
355
Transforming growth factor beta-1 proprotein
356
9.2
82
0.13
TGFB1TGFB1P07200P07200adaptiveimmuneresponsebasedonsomaticrecombinationofimmunereceptorsbuiltfromimmunoglobulinsuperfamilydomainsaorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaybranchelongationinvolvedinmammaryglandductbranchingbronchioledevelopmentcellmigrationcellmorphogenesiscell-celljunctionorganizationcellularcalciumionhomeostasiscellularresponsetoionizingradiationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetoviruschondrocytedifferentiationcolumnar/cuboidalepithelialcellmaturationcommon-partnerSMADproteinphosphorylationembryonicliverdevelopmentenamelmineralizationendodermdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialcellproliferationepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayfacemorphogenesisgeneexpressiongermcellmigrationhematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponseLangerhanscelldifferentiationlensfibercelldifferentiationlipopolysaccharide-mediatedsignalingpathwaylungalveolusdevelopmentlymphnodedevelopmentmammaryglandbranchinginvolvedinthelarcheMAPKcascademembraneproteinintracellulardomainproteolysismusclecellcellularhomeostasisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofepithelialcellproliferationnegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofinterleukin-17productionnegativeregulationofmacrophagecytokineproductionnegativeregulationofmyoblastdifferentiationnegativeregulationofossificationnegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationofTcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneuraltubeclosureNotchsignalingpathwayoligodendrocytedevelopmentossificationinvolvedinboneremodelingosteoclastdifferentiationpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocessphospholipidhomeostasispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofhistoneacetylationpositiveregulationofhistonedeacetylationpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofodontogenesispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorclusteringpositiveregulationofregulatoryTcelldifferentiationpositiveregulationofSMADproteinsignaltransductionpositiveregulationofstemcellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofactincytoskeletonreorganizationregulationofbindingregulationofbranchinginvolvedinmammaryglandductmorphogenesisregulationofcartilagedevelopmentregulationofcellpopulationproliferationregulationofDNAbindingregulationofinterleukin-23productionregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofsodiumiontransportregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulatoryTcelldifferentiationresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductionstemcellproliferationsurfactanthomeostasisTcellhomeostasisTcellproliferationtoleranceinductiontoselfantigentransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmenturetericbuddevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
Transient receptor potential cation channel subfamily M member 7
1606
Transient receptor potential cation channel subfamily M member 7
1606
9.2
79
0.14
TRPM7TRPM7Q923J1Q923J1actomyosinstructureorganizationcalciumiontransportcalcium-dependentcell-matrixadhesioncationtransmembranetransportcellularmagnesiumionhomeostasisdivalentinorganiccationhomeostasismemorynecroptoticprocesspositiveregulationofapoptoticprocessproteinautophosphorylationproteinphosphorylationproteintetramerization
Growth/differentiation factor 11
371
Growth/differentiation factor 11
313
9.2
81
0.13
GDF11GDF11O95390O95390amacrinecelldifferentiationcamera-typeeyemorphogenesiscellpopulationproliferationmesodermdevelopmentmetanephrosdevelopmentnegativeregulationofamacrinecelldifferentiationnegativeregulationofcellpopulationproliferationnervoussystemdevelopmentpositiveregulationofpathway-restrictedSMADproteinphosphorylationroofofmouthdevelopmentskeletalsystemdevelopmentSMADproteinsignaltransductionspinalcordanterior/posteriorpatterningtypeBpancreaticcellmaturationuretericbuddevelopment
Transforming growth factor beta-2 proprotein
317
Transforming growth factor beta-2 proprotein
379
9.2
73
0.15
TGFB2TGFB2P61812P61812activationofproteinkinaseactivityascendingaortamorphogenesisatrialseptummorphogenesisatrialseptumprimummorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwaycardiacepithelialtomesenchymaltransitioncardiacmusclecellproliferationcardiacrightventriclemorphogenesiscardioblastdifferentiationcelldeathcellmigrationcellmorphogenesiscell-celljunctionorganizationcollagenfibrilorganizationcranialskeletalsystemdevelopmentdopaminebiosyntheticprocessembryodevelopmentendinginbirthoregghatchingembryonicdigestivetractdevelopmentembryoniclimbmorphogenesisendocardialcushionfusionendocardialcushionmorphogenesisepithelialtomesenchymaltransitionextrinsicapoptoticsignalingpathwayeyedevelopmentgenerationofneuronsglialcellmigrationhairfollicledevelopmenthairfolliclemorphogenesisheartdevelopmentheartmorphogenesisheartvalvemorphogenesishemopoiesisinnereardevelopmentkidneydevelopmentmalegonaddevelopmentmembranousseptummorphogenesisnegativeregulationofalkalinephosphataseactivitynegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofepithelialcellproliferationnegativeregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationnegativeregulationofgeneexpressionnegativeregulationofmacrophagecytokineproductionnegativeregulationofRasproteinsignaltransductionneuralretinadevelopmentneuraltubeclosureneurondevelopmentneutrophilchemotaxisodontogenesisoutflowtractseptummorphogenesispathway-restrictedSMADproteinphosphorylationpharyngealarcharterymorphogenesispositiveregulationofcardioblastdifferentiationpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcellcyclepositiveregulationofcelldivisionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationpositiveregulationofheartcontractionpositiveregulationofimmuneresponsepositiveregulationofintegrinbiosyntheticprocesspositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationofNotchsignalingpathwaypositiveregulationofossificationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofstress-activatedMAPKcascadepositiveregulationoftimingofcatagenproteinphosphorylationpulmonaryvalvemorphogenesisregulationofapoptoticprocessinvolvedinoutflowtractmorphogenesisregulationofcellpopulationproliferationregulationoftimingofcatagenregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetoprogesteroneresponsetowoundingresponsetoxenobioticstimulussalivaryglandmorphogenesissecondarypalatedevelopmentskeletalsystemdevelopmentSMADproteinsignaltransductionsomaticstemcelldivisionsubstantiapropriaofcorneadevelopmenttransforminggrowthfactorbetareceptorsignalingpathwayuterinewallbreakdownuterusdevelopmentventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesiswoundhealing
Serine protease 1
48
Pancreatic trypsin inhibitor
49
9.2
98
0.11
TRY1BPT1P07477P00974digestionextracellularmatrixdisassemblyproteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Protein cereblon
394
Protein cereblon
329
9.2
74
0.15
CRBNCRBNQ8C7D2Q8C7D2locomotoryexplorationbehaviornegativeregulationofiontransmembranetransportnegativeregulationoflargeconductancecalcium-activatedpotassiumchannelactivitynegativeregulationofprotein-containingcomplexassemblypositiveregulationofprotein-containingcomplexassemblyproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitination
Beta-nerve growth factor
136
Beta-nerve growth factor
231
9.2
76
0.14
NGFNGFP01138P01138activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsmemorymodulationofchemicalsynaptictransmissionnegativeregulationofcellpopulationproliferationnegativeregulationofneuronapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwayneuronapoptoticprocessneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofcollateralsproutingpositiveregulationofDNAbindingpositiveregulationofgeneexpressionpositiveregulationofneurondifferentiationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofRasproteinsignaltransductionregulationofneurondifferentiationtransmembranereceptorproteintyrosinekinasesignalingpathway
Platelet-derived growth factor subunit A
123
Platelet-derived growth factor subunit A
140
9.2
65
0.17
PDGFAPDGFAP04085P04085actincytoskeletonorganizationangiogenesisanimalorganmorphogenesiscellactivationcellprojectionassemblycell-cellsignalingcellularresponsetotransforminggrowthfactorbetastimulusembryoniclungdevelopmenthairfollicledevelopmentinnereardevelopmentlungalveolusdevelopmentmalegonaddevelopmentnegativechemotaxisnegativeregulationofphosphatidylinositolbiosyntheticprocessnegativeregulationofplateletactivationplatelet-derivedgrowthfactorreceptorsignalingpathwayplatelet-derivedgrowthfactorreceptor-alphasignalingpathwaypositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmesenchymalcellproliferationpositiveregulationofmetanephricmesenchymalcellmigrationbyplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingregulationofactincytoskeletonorganizationregulationofbranchinginvolvedinsalivaryglandmorphogenesisbyepithelial-mesenchymalsignalingregulationofpeptidyl-tyrosinephosphorylationregulationofsmoothmusclecellmigrationresponsetoestradiolresponsetohypoxiaresponsetoinorganicsubstanceresponsetoretinoicacidresponsetowoundingresponsetoxenobioticstimulusskindevelopmentwoundhealing
Thialysine N-epsilon-acetyltransferase
158
Thialysine N-epsilon-acetyltransferase
122
9.2
63
0.17
SAT2SAT2Q96F10Q96F10nor-spermidinemetabolicprocessputrescineacetylationspermidineacetylationspermineacetylation
Interleukin-10
80
Interleukin-10
132
9.2
78
0.14
IL10IL10P18893P18893agingbranchinginvolvedinlabyrinthinelayermorphogenesiscellularresponsetoestradiolstimuluscellularresponsetohepatocytegrowthfactorstimuluscellularresponsetolipopolysaccharidechronicinflammatoryresponsetoantigenicstimulusdefenseresponsetobacteriumdefenseresponsetoprotozoanimmuneresponseliverregenerationnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofBcellproliferationnegativeregulationofcellpopulationproliferationnegativeregulationofchronicinflammatoryresponsetoantigenicstimulusnegativeregulationofcytokineactivitynegativeregulationofcytokineproductionnegativeregulationofcytokineproductioninvolvedinimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofheterotypiccell-celladhesionnegativeregulationofhydrogenperoxide-inducedneurondeathnegativeregulationofinflammatoryresponsenegativeregulationofinterferon-gammaproductionnegativeregulationofinterleukin-12productionnegativeregulationofinterleukin-6productionnegativeregulationofmembraneproteinectodomainproteolysisnegativeregulationofMHCclassIIbiosyntheticprocessnegativeregulationofmyeloiddendriticcellactivationnegativeregulationofneuronapoptoticprocessnegativeregulationofnitricoxidebiosyntheticprocessnegativeregulationofsensoryperceptionofpainnegativeregulationoftumornecrosisfactorproductionnegativeregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofBcellapoptoticprocesspositiveregulationofcellcyclepositiveregulationofcytokineproductionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellproliferationpositiveregulationofimmunoglobulinproductionpositiveregulationofmacrophageactivationpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofmiRNAtranscriptionpositiveregulationofplasmacelldifferentiationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsignalingreceptoractivitypositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofgeneexpressionregulationofresponsetowoundingregulationofsensoryperceptionofpainregulationofsynapseorganizationresponsetoactivityresponsetocarbonmonoxideresponsetoglucocorticoidresponsetoinactivityresponsetoinsulinresponsetomoleculeofbacterialoriginresponsetoxenobioticstimulus
Caspase-2
436
Caspase-2
366
9.2
78
0.14
CASP2CASP2P42575P42575activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessagingapoptoticprocessapoptoticsignalingpathwaybraindevelopmentcellularresponsetoDNAdamagestimuluscellularresponsetomechanicalstimulusDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestectopicgermcellprogrammedcelldeathexecutionphaseofapoptosisextrinsicapoptoticsignalingpathwayinabsenceofligandintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageluteolysisnegativeregulationofapoptoticprocessnegativeregulationofnecroptoticprocessneuralretinadevelopmentpositiveregulationofapoptoticprocesspositiveregulationofapoptoticsignalingpathwaypositiveregulationofneuronapoptoticprocessproteinprocessingreleaseofcytochromecfrommitochondria
Mismatch repair endonuclease PMS2
216
Mismatch repair endonuclease PMS2
216
9.2
92
0.12
PMS2PMS2P54278P54278mismatchrepairresponsetoxenobioticstimulussomatichypermutationofimmunoglobulingenes
Platelet-derived growth factor subunit B
97
Platelet-derived growth factor subunit B
124
9.2
64
0.17
PDGFBPDGFBP01127P01127activationofproteinkinaseactivityactivationofproteinkinaseBactivitycellchemotaxiscellularresponsetogrowthfactorstimuluscellularresponsetomycophenolicacidcellularresponsetoplatelet-derivedgrowthfactorstimulusembryonicplacentadevelopmentheartdevelopmentinterleukin-18-mediatedsignalingpathwaymetanephricglomerularmesangialcelldevelopmentmonocytechemotaxisnegativeregulationofgeneexpressionnegativeregulationofmiRNAtranscriptionnegativeregulationofphosphatidylinositolbiosyntheticprocessnegativeregulationofplateletactivationnegativeregulationofproteinbindingnegativeregulationoftranscriptionDNA-templatednegativeregulationofvascularassociatedsmoothmusclecelldifferentiationparacrinesignalingpeptidyl-serinephosphorylationpeptidyl-tyrosinephosphorylationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcalciumionimportpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-substrateadhesionpositiveregulationofchemotaxispositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglomerularfiltrationpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofhyaluronanbiosyntheticprocesspositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmetanephricmesenchymalcellmigrationpositiveregulationofmetanephricmesenchymalcellmigrationbyplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofmiRNAtranscriptionpositiveregulationofmitoticnucleardivisionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularassociatedsmoothmusclecelldedifferentiationpositiveregulationofvascularassociatedsmoothmusclecellmigrationpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseCsignalingproteinphosphorylationreactiveoxygenspeciesmetabolicprocessresponsetowounding
Bone morphogenetic protein 6
477
Bone morphogenetic protein 6
510
9.2
78
0.14
BMP6BMP6P22004P22004BMPsignalingpathwaycartilagedevelopmentcellularironionhomeostasiscellularresponsetoBMPstimuluscellularresponsetoironioncellularresponsetomechanicalstimulusendochondralossificationeyedevelopmentimmuneresponseinflammatoryresponsekidneydevelopmentmalegenitaliadevelopmentmulticellularorganismalironionhomeostasisnegativeregulationofadherensjunctionorganizationnegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationoftranscriptionbyRNApolymeraseIIneurondifferentiationosteoblastdifferentiationpositiveregulationofaldosteronebiosyntheticprocesspositiveregulationofaldosteronesecretionpositiveregulationofbonemineralizationpositiveregulationofcellpopulationproliferationpositiveregulationofchondrocytedifferentiationpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofgeneexpressionpositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofneurondifferentiationpositiveregulationofosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinsecretionpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularpermeabilityresponsetoactivityresponsetoglucocorticoidresponsetomagnesiumionresponsetoretinoicacidskeletalsystemdevelopmentSMADproteinsignaltransductiontypeBpancreaticcelldevelopment
ATP-binding cassette sub-family G member 5
225
ATP-binding cassette sub-family G member 8
109
9.2
65
0.17
ABCG5ABCG8Q9H222Q9H221bileacidsignalingpathwaycholesteroleffluxcholesterolhomeostasisintestinalcholesterolabsorptionnegativeregulationofintestinalcholesterolabsorptionnegativeregulationofintestinalphytosterolabsorptionresponsetoionizingradiationresponsetomuscleactivityresponsetonutrientresponsetoxenobioticstimulussteroltransporttransmembranetransporttriglyceridehomeostasisphospholipidtransport
DNA (cytosine-5)-methyltransferase 3A
540
DNA (cytosine-5)-methyltransferase 3A
517
9.2
89
0.12
DNM3ADNM3AQ9Y6K1Q9Y6K1agingC-5methylationofcytosinecellularresponsetoaminoacidstimuluscellularresponsetobisphenolAcellularresponsetoethanolcellularresponsetohypoxiaDNAmethylationDNAmethylationinvolvedinembryodevelopmentDNAmethylationinvolvedingametegenerationDNAmethylationoncytosineDNAmethylation-dependentheterochromatinassemblyhepatocyteapoptoticprocessmitoticcellcyclenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneurondifferentiationpositiveregulationofcelldeathregulationofgeneexpressionbygenomicimprintingresponsetococaineresponsetoestradiolresponsetoionizingradiationresponsetoleadionresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulusspermatogenesis
Pyruvate kinase PKLR
360
Pyruvate kinase PKLR
74
9.2
77
0.14
KPYRKPYRP12928P12928ATPbiosyntheticprocesscarbohydratemetabolicprocesscellularresponsetoepinephrinestimuluscellularresponsetoinsulinstimulusglycolyticprocesspyruvatebiosyntheticprocessresponsetoATPresponsetocAMPresponsetoglucoseresponsetoheatresponsetohypoxiaresponsetolithiumionresponsetometalionresponsetonutrientresponsetootherorganism
Fibrinogen alpha chain
64
Fibrinogen beta chain
106
9.2
83
0.13
FIBAFIBBP02671P02675adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncelladhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulus
GDP-mannose 4,6 dehydratase
142
GDP-mannose 4,6 dehydratase
142
9.2
63
0.17
GMDSGMDSO60547O60547"denovoGDP-L-fucosebiosyntheticprocess"GDP-mannosemetabolicprocessNotchsignalingpathway
Caspase-8
236
Caspase-8
426
9.2
72
0.15
CASP8CASP8Q14790Q14790activationofcysteine-typeendopeptidaseactivityactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessangiogenesisapoptoticprocessapoptoticsignalingpathwayBcellactivationcellularresponsetomechanicalstimuluscellularresponsetoorganiccycliccompoundexecutionphaseofapoptosisextrinsicapoptoticsignalingpathwayextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsheartdevelopmentmacrophagedifferentiationnaturalkillercellactivationnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofnecroptoticprocesspositiveregulationofapoptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-1betaproductionpositiveregulationofmacrophagedifferentiationpositiveregulationofneurondeathpositiveregulationofproteolysisproteolysisproteolysisinvolvedinproteincatabolicprocesspyroptosisregulationofcytokineproductionregulationofinnateimmuneresponseregulationoftumornecrosisfactor-mediatedsignalingpathwayresponsetoantibioticresponsetocobaltionresponsetocoldresponsetoestradiolresponsetoethanolresponsetolipopolysaccharideresponsetotumornecrosisfactorselfproteolysissyncytiotrophoblastcelldifferentiationinvolvedinlabyrinthinelayerdevelopmentTcellactivationTRAIL-activatedapoptoticsignalingpathway
Caspase-1
364
Caspase-1
397
9.2
67
0.16
CASP1CASP1P29466P29466apoptoticprocesscellularresponsetointerferon-gammacellularresponsetolipopolysaccharidecellularresponsetomechanicalstimuluscellularresponsetoorganicsubstancecytokineprecursorprocessingdefenseresponsetovirusicosanoidbiosyntheticprocessosmosensorysignalingpathwaypatternrecognitionreceptorsignalingpathwaypositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayproteinautoprocessingproteolysispyroptosisregulationofapoptoticprocessregulationofinflammatoryresponsesignaltransductionsignalingreceptorligandprecursorprocessing
Mineralocorticoid receptor
655
Mineralocorticoid receptor
655
9.2
78
0.14
MCRMCRP08235P08235intracellularsteroidhormonereceptorsignalingpathwaypositiveregulationofNIK/NF-kappaBsignalingregulationoftranscriptionbyRNApolymeraseIIsignaltransduction
C-C motif chemokine 16
37
C-C motif chemokine 16
38
9.2
75
0.14
CCL16CCL16O15467O15467cellcommunicationcell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
Inhibin beta A chain
390
Inhibin beta A chain
391
9.2
75
0.14
INHBAINHBAP08476P08476activinreceptorsignalingpathwaycelldifferentiationcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularresponsetocholesterolcellularresponsetofollicle-stimulatinghormonestimulusdefenseresponseendodermalcelldifferentiationerythrocytedifferentiationextrinsicapoptoticsignalingpathwayeyeliddevelopmentincamera-typeeyeGABAergicneurondifferentiationhairfollicledevelopmenthematopoieticprogenitorcelldifferentiationhemoglobinbiosyntheticprocessmalegonaddevelopmentmesodermalcelldifferentiationmulticellularorganismagingnegativeregulationofBcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationoffollicle-stimulatinghormonesecretionnegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofinterferon-gammaproductionnegativeregulationofmacrophagedifferentiationnegativeregulationofphosphorylationnervoussystemdevelopmentodontogenesisovarianfollicledevelopmentpositiveregulationoferythrocytedifferentiationpositiveregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandpositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofgeneexpressionpositiveregulationofovulationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprogesteronesecretionregulationoffollicle-stimulatinghormonesecretionregulationoftranscriptionbyRNApolymeraseIIresponsetoxenobioticstimulusroofofmouthdevelopmentSMADproteinsignaltransductionstriatalmediumspinyneurondifferentiationtranscriptionbyRNApolymeraseII
NKG2-D type II integral membrane protein
110
NKG2-D type II integral membrane protein
96
9.2
75
0.14
NKG2DNKG2DP26718P26718adaptiveimmuneresponsecelldifferentiationcellularresponsetolipopolysaccharidedefenseresponsetoGram-positivebacteriumnaturalkillercellactivationnaturalkillercellmediatedcytotoxicitynegativeregulationofGTPaseactivitynegativeregulationofnaturalkillercellchemotaxisnitricoxidebiosyntheticprocesspositiveregulationofinterferon-gammaproductionpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnitricoxidebiosyntheticprocesssignaltransductionstimulatoryC-typelectinreceptorsignalingpathwayTcellcostimulation
Fibrinogen beta chain
72
Fibrinogen gamma-B chain
47
9.2
73
0.15
FIBBFIBGP02676P12799adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioninnateimmuneresponseplateletaggregationproteinpolymerization
Fibrinogen gamma-B chain
47
Fibrinogen gamma-B chain
43
9.2
81
0.13
FIBGFIBGP12799P12799bloodcoagulationfibrinclotformationcell-matrixadhesionplateletaggregationproteinpolymerization
Caspase-7
290
Caspase-7
290
9.2
89
0.12
CASP7CASP7P55210P55210apoptoticprocesscellularresponsetostaurosporineexecutionphaseofapoptosisextrinsicapoptoticsignalingpathwayfibroblastapoptoticprocessheartdevelopmentinflammatoryresponseintrinsicapoptoticsignalingpathwayneuronapoptoticprocesspositiveregulationofapoptoticprocessproteinprocessingproteolysisresponsetoUV
Vascular endothelial growth factor A
77
Vascular endothelial growth factor A
94
9.2
60
0.18
VEGFAVEGFAP15692P15692activationofproteinkinaseactivityangiogenesisarterymorphogenesisbasophilchemotaxisbranchinginvolvedinbloodvesselmorphogenesiscamera-typeeyemorphogenesiscardiacmusclecelldevelopmentcardiacvascularsmoothmusclecelldevelopmentcellmaturationcellmigrationinvolvedinsproutingangiogenesiscellularresponsetohypoxiacellularresponsetovascularendothelialgrowthfactorstimuluscellularstressresponsetoacidchemicalcommissuralneuronaxonguidancecoronaryarterymorphogenesiscoronaryveinmorphogenesisdopaminergicneurondifferentiationendothelialcellchemotaxisepithelialcelldifferentiationeyephotoreceptorcelldevelopmentheartmorphogenesisinuteroembryonicdevelopmentinductionofpositivechemotaxiskidneydevelopmentlactationlungdevelopmentlymphvesselmorphogenesismacrophagedifferentiationmammaryglandalveolusdevelopmentmesodermdevelopmentmonocytedifferentiationmotorneuronmigrationnegativeregulationofadherensjunctionorganizationnegativeregulationofapoptoticprocessnegativeregulationofblood-brainbarrierpermeabilitynegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofestablishmentofendothelialbarriernegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentoutflowtractmorphogenesisovarianfollicledevelopmentpositivechemotaxispositiveregulationofangiogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelladhesionpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellmigrationbyvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofcellproliferationbyVEGF-activatedplateletderivedgrowthfactorreceptorsignalingpathwaypositiveregulationofcold-inducedthermogenesispositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialtubeformationpositiveregulationofERK1andERK2cascadepositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofhistonedeacetylaseactivitypositiveregulationofleukocytemigrationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmastcellchemotaxispositiveregulationofneuroblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofpositivechemotaxispositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinkinaseCsignalingpositiveregulationofproteinkinaseDsignalingpositiveregulationofproteinlocalizationtoearlyendosomepositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorinternalizationpositiveregulationofretinalganglioncellaxonguidancepositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftrophoblastcellmigrationpositiveregulationofvascularpermeabilitypost-embryoniccamera-typeeyedevelopmentprimitiveerythrocytedifferentiationregulationofcellshaperegulationofnitricoxidemediatedsignaltransductionregulationofretinalganglioncellaxonguidanceregulationoftranscriptionbyRNApolymeraseIIresponsetohypoxiasproutingangiogenesissurfactanthomeostasistubeformationvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorreceptor-2signalingpathwayvascularendothelialgrowthfactorsignalingpathwayvascularwoundhealingvasculogenesisVEGF-activatedneuropilinsignalingpathway
Glial cell line-derived neurotrophic factor
210
Glial cell line-derived neurotrophic factor
178
9.2
66
0.16
GDNFGDNFQ07731Q07731branchinginvolvedinuretericbudmorphogenesiscellpopulationproliferationcellularresponsetodexamethasonestimuluscommissuralneuronaxonguidancedorsalspinalcorddevelopmentembryonicorgandevelopmententericnervoussystemdevelopmentmalegonaddevelopmentmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesismetanephrosdevelopmentmidbraindevelopmentmRNAstabilizationnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofneuronapoptoticprocessnervoussystemdevelopmentneuralcrestcellmigrationneurondifferentiationneuronprojectiondevelopmentorganinductionperipheralnervoussystemdevelopmentperistalsispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesispositiveregulationofmonooxygenaseactivitypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofuretericbudformationpostganglionicparasympatheticfiberdevelopmentpostsynapticmembraneorganizationregulationofdopamineuptakeinvolvedinsynaptictransmissionregulationofgeneexpressionregulationofmorphogenesisofabranchingstructureregulationofsemaphorin-plexinsignalingpathwayregulationofuretericbudformationresponsetowoundingretinadevelopmentincamera-typeeyesympatheticnervoussystemdevelopmenturetericbuddevelopmenturetericbudformation
Transforming growth factor beta-1 proprotein
355
Transforming growth factor beta-1 proprotein
389
9.2
78
0.14
TGFB1TGFB1P07200P07200adaptiveimmuneresponsebasedonsomaticrecombinationofimmunereceptorsbuiltfromimmunoglobulinsuperfamilydomainsaorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaybranchelongationinvolvedinmammaryglandductbranchingbronchioledevelopmentcellmigrationcellmorphogenesiscell-celljunctionorganizationcellularcalciumionhomeostasiscellularresponsetoionizingradiationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetoviruschondrocytedifferentiationcolumnar/cuboidalepithelialcellmaturationcommon-partnerSMADproteinphosphorylationembryonicliverdevelopmentenamelmineralizationendodermdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialcellproliferationepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayfacemorphogenesisgeneexpressiongermcellmigrationhematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponseLangerhanscelldifferentiationlensfibercelldifferentiationlipopolysaccharide-mediatedsignalingpathwaylungalveolusdevelopmentlymphnodedevelopmentmammaryglandbranchinginvolvedinthelarcheMAPKcascademembraneproteinintracellulardomainproteolysismusclecellcellularhomeostasisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofepithelialcellproliferationnegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofinterleukin-17productionnegativeregulationofmacrophagecytokineproductionnegativeregulationofmyoblastdifferentiationnegativeregulationofossificationnegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationofTcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneuraltubeclosureNotchsignalingpathwayoligodendrocytedevelopmentossificationinvolvedinboneremodelingosteoclastdifferentiationpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocessphospholipidhomeostasispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofhistoneacetylationpositiveregulationofhistonedeacetylationpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofodontogenesispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorclusteringpositiveregulationofregulatoryTcelldifferentiationpositiveregulationofSMADproteinsignaltransductionpositiveregulationofstemcellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofactincytoskeletonreorganizationregulationofbindingregulationofbranchinginvolvedinmammaryglandductmorphogenesisregulationofcartilagedevelopmentregulationofcellpopulationproliferationregulationofDNAbindingregulationofinterleukin-23productionregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofsodiumiontransportregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulatoryTcelldifferentiationresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductionstemcellproliferationsurfactanthomeostasisTcellhomeostasisTcellproliferationtoleranceinductiontoselfantigentransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmenturetericbuddevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
Fibrinogen alpha chain
184
Fibrinogen gamma chain
165
9.4
77
0.14
FIBAFIBGP02671Q53Y18adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-1cellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Glucocorticoid receptor
492
Glucocorticoid receptor
492
9.4
81
0.13
GCRGCRP06536P06536adrenalglanddevelopmentagingandrogenmetabolicprocessbraindevelopmentcellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetomagnesiumioncellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinremodelingcircadianrhythmepigeneticmaintenanceofchromatinintranscription-competentconformationfemalepregnancyglucocorticoidmetabolicprocessglucocorticoidreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaylungdevelopmentmammaryglandductmorphogenesismaternalbehaviormuscleatrophynegativeregulationofapoptoticprocessnegativeregulationofsynapticplasticitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationofvascularpermeabilitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofdendriticspinedevelopmentpositiveregulationofglucocorticoidreceptorsignalingpathwaypositiveregulationofglutamatesecretionpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprotein-containingcomplexassemblyregulationofcellpopulationproliferationregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationofglucosemetabolicprocessregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetoactivityresponsetoarsenic-containingsubstanceresponsetocalciumionresponsetocorticosteroneresponsetodexamethasoneresponsetoelectricalstimulusresponsetoinactivityresponsetoinsulinresponsetomercuryionresponsetoradiation
Aldehyde dehydrogenase family 1 member A3
164
Aldehyde dehydrogenase family 1 member A3
467
9.4
81
0.13
AL1A3AL1A3P47895P47895apoptoticprocessembryoniccamera-typeeyedevelopmentembryoniceyemorphogenesisfacedevelopmentHarderianglanddevelopmentinnerearmorphogenesislocomotorybehaviorneuromuscularprocesscontrollingbalancenucleusaccumbensdevelopmentolfactorypitdevelopmentopticcupmorphogenesisinvolvedincamera-typeeyedevelopmentpositiveregulationofapoptoticprocessproteinhomotetramerizationretinalmetabolicprocessretinoicacidbiosyntheticprocessretinoicacidmetabolicprocessretinolmetabolicprocessrightingreflex
Isoform L-VEGF206 of Vascular endothelial growth factor A
232
Isoform L-VEGF206 of Vascular endothelial growth factor A
257
9.4
69
0.15
VEGFAVEGFAP15692-14P15692-14
Neutrophil defensin 1
94
Neutrophil defensin 1
83
9.4
nan
nan
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismmodificationbyhostofsymbiontmembraneTcellchemotaxis
Growth/differentiation factor 8
339
Growth/differentiation factor 8
309
9.4
90
0.12
GDF8GDF8O14793O14793cellularresponsetodexamethasonestimulusmusclecellcellularhomeostasismuscleorgandevelopmentmyoblastmigrationinvolvedinskeletalmuscleregenerationnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofkinaseactivitynegativeregulationofmusclehypertrophynegativeregulationofmyoblastdifferentiationnegativeregulationofmyoblastproliferationnegativeregulationofproteinkinaseBsignalingnegativeregulationofsatellitecelldifferentiationnegativeregulationofskeletalmusclesatellitecellproliferationnegativeregulationofskeletalmuscletissuegrowthovulationcycleprocesspositiveregulationoflamellipodiumassemblypositiveregulationofmacrophagechemotaxispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionDNA-templatedresponsetoelectricalstimulusresponsetoestrogenresponsetoethanolresponsetogravityresponsetoheatresponsetomuscleactivityresponsetotestosteroneskeletalmuscleatrophySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Acyloxyacyl hydrolase
113
Acyloxyacyl hydrolase
453
9.4
65
0.16
AOAHAOAHO18823O18823fattyacidmetabolicprocesslipopolysaccharidecatabolicprocess
Bone morphogenetic protein 3
471
Bone morphogenetic protein 3
436
9.4
89
0.12
BMP3BMP3P12645P12645cartilagedevelopmentcell-cellsignalingosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationskeletalsystemdevelopmentSMADproteinsignaltransduction
Acyl-protein thioesterase 1
211
Acyl-protein thioesterase 1
211
9.4
76
0.14
LYPA1LYPA1O75608O75608fattyacidmetabolicprocessnegativeregulationofGolgitoplasmamembraneproteintransportproteindepalmitoylation
Norrin
95
Norrin
69
9.4
80
0.13
NDPNDPQ00604Q00604decidualizationextracellularmatrix-cellsignalingnervoussystemdevelopmentNorrinsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoftranscriptionDNA-templatedretinavasculaturemorphogenesisincamera-typeeyevacuoleorganizationvisualperceptionWntsignalingpathway
Tumor protein p73
194
Tumor protein p73
194
9.4
68
0.16
P73P73O15350O15350cellcyclecellularresponsetoDNAdamagestimulusintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorkidneydevelopmentmismatchrepairnegativeregulationofcardiacmusclecellproliferationnegativeregulationofcellpopulationproliferationnegativeregulationofneurondifferentiationpositiveregulationofapoptoticprocesspositiveregulationoflungciliatedcelldifferentiationpositiveregulationofMAPKcascadepositiveregulationofoligodendrocytedifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedproteintetramerizationregulationofcellcycleregulationofgeneexpressionregulationofmitoticcellcycleregulationoftranscriptionbyRNApolymeraseIIresponsetoorganonitrogencompoundresponsetoxenobioticstimulus
Endothelin receptor type B
358
Endothelin-3
107
9.4
78
0.14
EDNRBEDN3P24530P14138agingaldosteronemetabolicprocesscalciumiontransmembranetransportcalcium-mediatedsignalingcanonicalWntsignalingpathwaycellsurfacereceptorsignalingpathwaycellularresponsetolipopolysaccharidecGMP-mediatedsignalingdevelopmentalpigmentationendothelinreceptorsignalingpathwayentericnervoussystemdevelopmententericsmoothmusclecelldifferentiationepithelialfluidtransportestablishmentofendothelialbarriergeneexpressionheparinmetabolicprocessI-kappaBkinase/NF-kappaBsignalingmacrophagechemotaxismelanocytedifferentiationnegativeregulationofadenylatecyclaseactivitynegativeregulationofapoptoticprocessnegativeregulationofneuronmaturationnegativeregulationofproteinmetabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentneuralcrestcellmigrationneuroblastmigrationperipheralnervoussystemdevelopmentpharynxdevelopmentphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypodocytedifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofpenileerectionpositiveregulationofproteinphosphorylationpositiveregulationofrenalsodiumexcretionpositiveregulationofurinevolumeposteriormidgutdevelopmentproteintransmembranetransportregulationofepithelialcellproliferationregulationoffevergenerationregulationofheartrateregulationofpHregulationofsensoryperceptionofpainrenalalbuminabsorptionrenalsodiumexcretionrenalsodiumionabsorptionreninsecretionintobloodstreamresponsetoendothelinresponsetoorganiccycliccompoundresponsetopainresponsetosodiumphosphatesensoryperceptionofpainvasoconstrictionvasodilationveinsmoothmusclecontractionaxonextensionaxonguidancebloodcirculationcellpopulationproliferationcell-cellsignalingcellularcalciumionhomeostasiscellularmagnesiumionhomeostasisestablishmentoflocalizationincellinositolphosphate-mediatedsignalingneutrophilchemotaxispeptidehormonesecretionpositiveregulationofcelldifferentiationpositiveregulationofheartratepositiveregulationofhormonesecretionpositiveregulationofleukocytechemotaxispositiveregulationofMAPkinaseactivitypositiveregulationofmitoticnucleardivisionpositiveregulationofpotassiumiontransmembranetransportpositiveregulationofprostaglandin-endoperoxidesynthaseactivitypotassiumiontransmembranetransportregulationofdevelopmentalpigmentationregulationofgeneexpressionregulationofsystemicarterialbloodpressurebyendothelinregulationofvasoconstrictionsignaltransduction
Tumor necrosis factor ligand superfamily member 13B
232
Tumor necrosis factor ligand superfamily member 13B
245
9.4
94
0.11
TN13BTN13BQ9Y275Q9Y275BcellcostimulationBcelldifferentiationBcellhomeostasisBcellproliferationgerminalcenterformationpositiveregulationofBcellproliferationpositiveregulationofgerminalcenterformationpositiveregulationofTcellproliferationsignaltransductionTcellcostimulationTcellproliferationtumornecrosisfactor-mediatedsignalingpathway
Ectodysplasin-A
332
Ectodysplasin-A
346
9.4
94
0.11
EDAEDAQ92838Q92838animalorgandevelopmentcanonicalWntsignalingpathwaycelldifferentiationcell-matrixadhesioncytokine-mediatedsignalingpathwaygeneexpressionhairfollicleplacodeformationimmuneresponseodontogenesisofdentin-containingtoothpigmentationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingregulationofNIK/NF-kappaBsignalingsalivaryglandcavitationtracheaglanddevelopment
Coagulation factor X
342
Coagulation factor X
151
9.4
75
0.14
FA10FA10P00742P00742bloodcoagulationbloodcoagulationcommonpathwaypositiveregulationofcellmigrationpositiveregulationofproteinkinaseBsignalingproteolysiszymogenactivation
Beta-secretase 2
393
Beta-secretase 2
344
9.4
77
0.14
BACE2BACE2Q9Y5Z0Q9Y5Z0amyloid-betametabolicprocessglucosehomeostasismembraneproteinectodomainproteolysisnegativeregulationofamyloidprecursorproteinbiosyntheticprocesspeptidehormoneprocessingproteolysis
Glutathione S-transferase Mu 1
78
Glutathione S-transferase Mu 1
78
9.4
80
0.13
GSTM1GSTM1P09488P09488cellulardetoxificationofnitrogencompoundglutathionederivativebiosyntheticprocessglutathionemetabolicprocesshepoxilinbiosyntheticprocessnitrobenzenemetabolicprocessprostaglandinmetabolicprocessxenobioticcatabolicprocess
Dihydropyrimidinase-related protein 1
323
Dihydropyrimidinase-related protein 1
323
9.4
73
0.15
DPYL1DPYL1Q14194Q14194axonguidancemicrotubulecytoskeletonorganizationnegativeregulationofactinfilamentbindingnegativeregulationofneuronprojectiondevelopmentnervoussystemdevelopmentnucleobase-containingcompoundmetabolicprocess
Glucocorticoid receptor
473
Glucocorticoid receptor
473
9.4
78
0.14
GCRGCRP04150P04150adrenalglanddevelopmentapoptoticprocesscellcyclecelldivisioncellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinorganizationchromosomesegregationglucocorticoidmetabolicprocessintracellularsteroidhormonereceptorsignalingpathwaymammaryglandductmorphogenesismaternalbehaviornegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedsignaltransduction
Lamina-associated polypeptide 2, isoforms alpha/zeta
560
Lamina-associated polypeptide 2, isoforms alpha/zeta
560
9.4
51
0.21
LAP2ALAP2AQ61033Q61033regulationoftranscriptionDNA-templated
Protein timeless homolog
1025
Protein timeless homolog
1025
9.4
78
0.14
TIMTIMQ9UNS1Q9UNS1branchingmorphogenesisofanepithelialtubecellcyclephasetransitioncelldivisioncellularresponsetobleomycincellularresponsetocisplatincellularresponsetoDNAdamagestimuluscellularresponsetohydroxyureacircadianrhythmdetectionofabioticstimulusDNArepairDNAreplicationcheckpointsignalinglungdevelopmentmorphogenesisofanepitheliumnegativeregulationoftranscriptionDNA-templatedpositiveregulationofdouble-strandbreakrepairpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationregulationofcircadianrhythmreplicationforkarrestreplicationforkprotection
Alcohol dehydrogenase 1C
101
Alcohol dehydrogenase 1C
287
9.4
68
0.16
ADH1GADH1GP00326P00326ethanoloxidationretinoicacidmetabolicprocessretinolmetabolicprocess
Cyclin-dependent kinase 8
64
Cyclin-C
148
9.4
75
0.14
CDK8CCNCP49336P24863proteinphosphorylationG0toG1transitionnegativeregulationofNotchsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Speckle-type POZ protein
184
Speckle-type POZ protein
184
9.4
50
0.21
SPOPSPOPO43791O43791proteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationregulationofproteolysis
Vascular endothelial growth factor A
77
Vascular endothelial growth factor A
87
9.4
66
0.16
VEGFAVEGFAP15692P15692activationofproteinkinaseactivityangiogenesisarterymorphogenesisbasophilchemotaxisbranchinginvolvedinbloodvesselmorphogenesiscamera-typeeyemorphogenesiscardiacmusclecelldevelopmentcardiacvascularsmoothmusclecelldevelopmentcellmaturationcellmigrationinvolvedinsproutingangiogenesiscellularresponsetohypoxiacellularresponsetovascularendothelialgrowthfactorstimuluscellularstressresponsetoacidchemicalcommissuralneuronaxonguidancecoronaryarterymorphogenesiscoronaryveinmorphogenesisdopaminergicneurondifferentiationendothelialcellchemotaxisepithelialcelldifferentiationeyephotoreceptorcelldevelopmentheartmorphogenesisinuteroembryonicdevelopmentinductionofpositivechemotaxiskidneydevelopmentlactationlungdevelopmentlymphvesselmorphogenesismacrophagedifferentiationmammaryglandalveolusdevelopmentmesodermdevelopmentmonocytedifferentiationmotorneuronmigrationnegativeregulationofadherensjunctionorganizationnegativeregulationofapoptoticprocessnegativeregulationofblood-brainbarrierpermeabilitynegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofestablishmentofendothelialbarriernegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentoutflowtractmorphogenesisovarianfollicledevelopmentpositivechemotaxispositiveregulationofangiogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelladhesionpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellmigrationbyvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofcellproliferationbyVEGF-activatedplateletderivedgrowthfactorreceptorsignalingpathwaypositiveregulationofcold-inducedthermogenesispositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialtubeformationpositiveregulationofERK1andERK2cascadepositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofhistonedeacetylaseactivitypositiveregulationofleukocytemigrationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmastcellchemotaxispositiveregulationofneuroblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofpositivechemotaxispositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinkinaseCsignalingpositiveregulationofproteinkinaseDsignalingpositiveregulationofproteinlocalizationtoearlyendosomepositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorinternalizationpositiveregulationofretinalganglioncellaxonguidancepositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftrophoblastcellmigrationpositiveregulationofvascularpermeabilitypost-embryoniccamera-typeeyedevelopmentprimitiveerythrocytedifferentiationregulationofcellshaperegulationofnitricoxidemediatedsignaltransductionregulationofretinalganglioncellaxonguidanceregulationoftranscriptionbyRNApolymeraseIIresponsetohypoxiasproutingangiogenesissurfactanthomeostasistubeformationvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorreceptor-2signalingpathwayvascularendothelialgrowthfactorsignalingpathwayvascularwoundhealingvasculogenesisVEGF-activatedneuropilinsignalingpathway
cGMP-dependent protein kinase 1
175
cGMP-dependent protein kinase 1
158
9.4
45
0.24
KGP1KGP1Q6P5T7Q6P5T7actincytoskeletonorganizationcGMP-mediatedsignalingdendritedevelopmentforebraindevelopmentnegativeregulationofplateletaggregationnegativeregulationofvascularassociatedsmoothmusclecellmigrationnegativeregulationofvascularassociatedsmoothmusclecellproliferationneuronmigrationproteinphosphorylationregulationofGTPaseactivityrelaxationofvascularassociatedsmoothmusclesignaltransduction
Protein S100-A4
81
Protein S100-A4
76
9.4
58
0.18
S10A4S10A4P26447P26447epithelialtomesenchymaltransitionpositiveregulationofI-kappaBkinase/NF-kappaBsignaling
Vasopressin-neurophysin 2-copeptin
105
Vasopressin-neurophysin 2-copeptin
110
9.4
98
0.11
NEU2NEU2P01180P01180vasoconstriction
Superoxide dismutase [Cu-Zn]
112
Superoxide dismutase [Cu-Zn]
112
9.4
77
0.14
SODCSODCP00441P00441aginganterogradeaxonaltransportapoptoticprocessauditoryreceptorcellstereociliumorganizationcellularironionhomeostasiscellularresponsetoATPcellularresponsetocadmiumioncellularresponsetopotassiumionectopicgermcellprogrammedcelldeathembryoimplantationglutathionemetabolicprocessheartcontractionhydrogenperoxidebiosyntheticprocesslocomotorybehaviormusclecellcellularhomeostasismyeloidcellhomeostasisnegativeregulationofcholesterolbiosyntheticprocessnegativeregulationofdevelopmentalprocessnegativeregulationofinflammatoryresponsenegativeregulationofneuronapoptoticprocessnegativeregulationofreproductiveprocessneurofilamentcytoskeletonorganizationovarianfollicledevelopmentperipheralnervoussystemmyelinmaintenanceplacentadevelopmentpositiveregulationofapoptoticprocesspositiveregulationofcatalyticactivitypositiveregulationofcytokineproductionpositiveregulationofMAPKcascadepositiveregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaypositiveregulationofphagocytosispositiveregulationofsuperoxideaniongenerationreactiveoxygenspeciesmetabolicprocessregulationofbloodpressureregulationofGTPaseactivityregulationofmitochondrialmembranepotentialregulationofmulticellularorganismgrowthregulationoforgangrowthregulationofproteinkinaseactivityregulationofTcelldifferentiationinthymusrelaxationofvascularassociatedsmoothmuscleremovalofsuperoxideradicalsresponsetoamphetamineresponsetoantibioticresponsetoantipsychoticdrugresponsetoaxoninjuryresponsetocarbonmonoxideresponsetocopperionresponsetoethanolresponsetoheatresponsetohydrogenperoxideresponsetonutrientlevelsresponsetoorganicsubstanceresponsetosuperoxideresponsetoxenobioticstimulusretinahomeostasisretrogradeaxonaltransportsensoryperceptionofsoundspermatogenesissuperoxideaniongenerationsuperoxidemetabolicprocessthymusdevelopmenttransmissionofnerveimpulse
Mismatch repair endonuclease PMS2
216
Mismatch repair endonuclease PMS2
202
9.4
88
0.12
PMS2PMS2P54278P54278mismatchrepairresponsetoxenobioticstimulussomatichypermutationofimmunoglobulingenes
D-3-phosphoglycerate dehydrogenase
281
D-3-phosphoglycerate dehydrogenase
116
9.4
99
0.11
SERASERAO43175O43175braindevelopmentG1toG0transitiongamma-aminobutyricacidmetabolicprocessglialcelldevelopmentglutaminemetabolicprocessglycinemetabolicprocessL-serinebiosyntheticprocessneuraltubedevelopmentneuronprojectiondevelopmentregulationofgeneexpressionspinalcorddevelopmenttaurinemetabolicprocessthreoninemetabolicprocess
Protein PML
72
Protein PML
88
9.2
68
0.16
PMLPMLP29590P29590activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocessbranchinginvolvedinmammaryglandductmorphogenesiscellfatecommitmentcellularresponsetointerleukin-4cellularresponsetoleukemiainhibitoryfactorcellularsenescencecircadianregulationofgeneexpressioncommon-partnerSMADproteinphosphorylationDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestendoplasmicreticulumcalciumionhomeostasisentrainmentofcircadianclockbyphotoperiodextrinsicapoptoticsignalingpathwayfibroblastmigrationinnateimmuneresponseintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressintrinsicapoptoticsignalingpathwayinresponsetooxidativestressmaintenanceofproteinlocationinnucleusmyeloidcelldifferentiationnegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofinterleukin-1betaproductionnegativeregulationofmitoticcellcyclenegativeregulationoftelomeraseactivitynegativeregulationoftelomeremaintenanceviatelomerasenegativeregulationoftranscriptionDNA-templatednegativeregulationoftranslationinresponsetooxidativestressnegativeregulationofubiquitin-dependentproteincatabolicprocessoncogene-inducedcellsenescencePMLbodyorganizationpositiveregulationofapoptoticprocessinvolvedinmammaryglandinvolutionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationoffibroblastproliferationpositiveregulationofhistonedeacetylationpositiveregulationofpeptidyl-lysineacetylationpositiveregulationofproteinlocalizationtochromosometelomericregionpositiveregulationofsignaltransductionbyp53classmediatorpositiveregulationoftelomeremaintenancepositiveregulationoftranscriptionDNA-templatedproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinimportintonucleusproteinstabilizationproteintargetingprotein-containingcomplexassemblyprotein-containingcomplexlocalizationregulationofcalciumiontransportintocytosolregulationofcelladhesionregulationofcellcycleregulationofcircadianrhythmregulationofdouble-strandbreakrepairregulationoftranscriptionDNA-templatedresponsetocytokineresponsetogammaradiationresponsetohypoxiaresponsetoUVretinoicacidreceptorsignalingpathwaysuppressionofviralreleasebyhosttransforminggrowthfactorbetareceptorsignalingpathway
Threonine aspartase 1
163
Threonine aspartase 1
271
9.2
89
0.12
TASP1TASP1Q9H6P5Q9H6P5positiveregulationoftranscriptionDNA-templatedproteinmaturationproteolysis
Sequestosome-1
131
Sequestosome-1
145
9.2
64
0.17
SQSTMSQSTMQ13501Q13501aggrephagyapoptoticprocessautophagyautophagyofmitochondrionbrownfatcellproliferationcelldifferentiationendosomaltransportendosomeorganizationenergyhomeostasisimmunesystemprocessintracellularsignaltransductionmacroautophagymitophagynegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofapoptoticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinimportintonucleusproteinlocalizationproteinlocalizationtoperinuclearregionofcytoplasmproteinphosphorylationregulationofI-kappaBkinase/NF-kappaBsignalingregulationofmitochondrionorganizationregulationofproteincomplexstabilityregulationofRasproteinsignaltransductionresponsetoischemiaresponsetomitochondrialdepolarisationselectiveautophagytemperaturehomeostasistranscriptionbyRNApolymeraseIIubiquitin-dependentproteincatabolicprocess
Urokinase plasminogen activator surface receptor
39
Urokinase plasminogen activator surface receptor
98
9.2
51
0.21
UPARUPARQ03405Q03405bloodcoagulationchemotaxisnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaynegativeregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofDNAbindingpositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofhomotypiccell-celladhesionpositiveregulationofproteinphosphorylationpositiveregulationofreleaseofcytochromecfrommitochondriaregulationofcelladhesionregulationoffibrinolysisregulationofplasminogenactivationregulationofproteolysissignaltransductionurokinaseplasminogenactivatorsignalingpathway
Fibrinogen alpha chain
180
Fibrinogen beta chain
227
9.2
75
0.14
FIBAFIBBP02671P02675adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncelladhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulus
Caspase-6
277
Caspase-6
277
9.2
86
0.13
CASP6CASP6P55212P55212activationofcysteine-typeendopeptidaseactivityactivationofinnateimmuneresponseapoptoticprocesscellularresponsetostaurosporineepithelialcelldifferentiationhepatocyteapoptoticprocessintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofapoptoticprocesspositiveregulationofnecroptoticprocessproteinautoprocessingproteolysispyroptosisregulationofmitochondrialoutermembranepermeabilizationinvolvedinapoptoticsignalingpathway
Microtubule-associated protein RP/EB family member 1
228
Microtubule-associated protein RP/EB family member 1
228
9.2
71
0.15
MARE1MARE1Q15691Q15691attachmentofmitoticspindlemicrotubulestokinetochorecelldivisioncellmigrationestablishmentofmitoticspindleorientationmicrotubulebundleformationmicrotubulepolymerizationnegativeregulationofmicrotubulepolymerizationnon-motileciliumassemblypositiveregulationofmicrotubuleplus-endbindingpositiveregulationofmicrotubulepolymerizationproteinlocalizationproteinlocalizationtoastralmicrotubuleproteinlocalizationtocentrosomeproteinlocalizationtomicrotubuleproteinlocalizationtomicrotubuleplus-endregulationofmicrotubulepolymerizationordepolymerizationspindleassembly
Asparaginase
79
Asparaginase
79
9.2
72
0.15
H0W0T5H0W0T5H0W0T5H0W0T5aspartatefamilyaminoacidmetabolicprocess
Eukaryotic translation initiation factor 3 subunit J
188
Eukaryotic translation initiation factor 3 subunit J
188
9.2
85
0.13
EIF3JEIF3JO75822O75822formationofcytoplasmictranslationinitiationcomplextranslationalinitiation
Leucine carboxyl methyltransferase 1
136
Leucine carboxyl methyltransferase 1
136
9.2
64
0.17
LCMT1LCMT1Q9UIC8Q9UIC8C-terminalproteinmethylationG2/Mtransitionofmitoticcellcyclenegativeregulationofprotein-containingcomplexassemblyproteinmethylationproteinmodificationprocessregulationofapoptoticprocessregulationofglucosemetabolicprocessregulationofmitoticcellcyclespindleassemblycheckpoint
Ceramide transfer protein
65
Ceramide transfer protein
27
9.4
63
0.17
CERTCERTQ9Y5P4Q9Y5P4cellmorphogenesiscellpopulationproliferationceramidemetabolicprocessceramidetransportendoplasmicreticulumorganizationERtoGolgiceramidetransportheartmorphogenesisimmuneresponseinuteroembryonicdevelopmentintermembranelipidtransferintermembranesphingolipidtransferlipidhomeostasismitochondrionmorphogenesismusclecontractionresponsetoendoplasmicreticulumstresssignaltransduction
Glutamate receptor ionotropic, delta-2
83
Glutamate receptor ionotropic, delta-2
83
9.4
81
0.13
GRID2GRID2Q63226Q63226cerebellargranulecelldifferentiationexcitatorypostsynapticpotentialexcitatorysynapseassemblyheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesmodulationofchemicalsynaptictransmissionpositiveregulationoflong-termsynapticdepressionpositiveregulationofsynapseassemblyprepulseinhibitionproteinlocalizationregulationofneuronapoptoticprocessregulationofneuronprojectiondevelopmentregulationofpostsynapticdensityassemblyregulationofpresynapseassemblysynaptictransmissionglutamatergic
Caspase-8
360
Caspase-8
409
9.4
70
0.15
CASP8CASP8Q14790Q14790activationofcysteine-typeendopeptidaseactivityactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessangiogenesisapoptoticprocessapoptoticsignalingpathwayBcellactivationcellularresponsetomechanicalstimuluscellularresponsetoorganiccycliccompoundexecutionphaseofapoptosisextrinsicapoptoticsignalingpathwayextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsheartdevelopmentmacrophagedifferentiationnaturalkillercellactivationnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofnecroptoticprocesspositiveregulationofapoptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-1betaproductionpositiveregulationofmacrophagedifferentiationpositiveregulationofneurondeathpositiveregulationofproteolysisproteolysisproteolysisinvolvedinproteincatabolicprocesspyroptosisregulationofcytokineproductionregulationofinnateimmuneresponseregulationoftumornecrosisfactor-mediatedsignalingpathwayresponsetoantibioticresponsetocobaltionresponsetocoldresponsetoestradiolresponsetoethanolresponsetolipopolysaccharideresponsetotumornecrosisfactorselfproteolysissyncytiotrophoblastcelldifferentiationinvolvedinlabyrinthinelayerdevelopmentTcellactivationTRAIL-activatedapoptoticsignalingpathway
C-C motif chemokine 5
34
C-C motif chemokine 5
33
9.4
76
0.14
CCL5CCL5P13501P13501activationofphospholipaseDactivitycalciumiontransportcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetoviruschemokine-mediatedsignalingpathwaychemotaxisdendriticcellchemotaxiseosinophilchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwayinflammatoryresponseleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofinnateimmuneresponsepositiveregulationofmacrophagechemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftranslationalinitiationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofviralgenomereplicationproteinkinaseBsignalingregulationofchronicinflammatoryresponseregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetotoxicsubstanceresponsetovirus
Vitamin K-dependent protein C
319
Vitamin K-dependent protein C
175
9.4
74
0.14
PROCPROCP04070P04070bloodcoagulationnegativeregulationofapoptoticprocessnegativeregulationofbloodcoagulationnegativeregulationofcoagulationnegativeregulationofinflammatoryresponsepositiveregulationofestablishmentofendothelialbarrierproteolysis
Hypoxanthine-guanine phosphoribosyltransferase
66
Hypoxanthine-guanine phosphoribosyltransferase
66
9.4
76
0.14
HPRTHPRTP00492P00492adeninemetabolicprocessAMPsalvagecentralnervoussystemneurondevelopmentcerebralcortexneurondifferentiationdendritemorphogenesisdopaminemetabolicprocessdopaminergicneurondifferentiationGMPcatabolicprocessGMPsalvagegroomingbehaviorguaninesalvagehypoxanthinemetabolicprocesshypoxanthinesalvageIMPmetabolicprocessIMPsalvagelocomotorybehaviorlymphocyteproliferationpositiveregulationofdopaminemetabolicprocessproteinhomotetramerizationpurinenucleotidebiosyntheticprocesspurineribonucleosidesalvageresponsetoamphetaminestriatumdevelopmentTcellmediatedcytotoxicity
Resistin-like beta
61
Resistin-like beta
49
9.4
69
0.15
RETNBRETNBQ99P86Q99P86responsetobacterium
Suppressor of tumorigenicity 14 protein
657
Pancreatic trypsin inhibitor
73
9.4
92
0.12
ST14BPT1Q9Y5Y6P00974epithelialcellmorphogenesisinvolvedinplacentalbranchingkeratinocytedifferentiationneuraltubeclosureproteincatabolicprocessproteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Lysine-specific demethylase 2A
333
Lysine-specific demethylase 2A
477
9.4
66
0.16
F6YRW4F6YRW4F6YRW4F6YRW4chromatinorganizationcircadianregulationofgeneexpressiondouble-strandbreakrepairvianonhomologousendjoininghistoneH3-K36demethylationnegativeregulationoftranscriptionbycompetitivepromoterbindingregulationofcircadianrhythm
Urokinase plasminogen activator surface receptor
67
Urokinase plasminogen activator surface receptor
98
9.4
63
0.17
UPARUPARQ03405Q03405bloodcoagulationchemotaxisnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaynegativeregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofDNAbindingpositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofhomotypiccell-celladhesionpositiveregulationofproteinphosphorylationpositiveregulationofreleaseofcytochromecfrommitochondriaregulationofcelladhesionregulationoffibrinolysisregulationofplasminogenactivationregulationofproteolysissignaltransductionurokinaseplasminogenactivatorsignalingpathway
Kallikrein-6
47
Amyloid-beta precursor protein
300
9.4
101
0.11
KLK6A4Q92876P05067amyloidprecursorproteinmetabolicprocesscentralnervoussystemdevelopmentcollagencatabolicprocesshormonemetabolicprocessmyelinationpositiveregulationofGprotein-coupledreceptorsignalingpathwayproteinautoprocessingregulationofcelldifferentiationregulationofneuronprojectiondevelopmentresponsetowoundingtissueregenerationadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Fibrinogen alpha chain
184
Fibrinogen gamma chain
165
9.2
71
0.15
FIBAFIBGP02671P02679adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-1cellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Galectin
17
Galectin
17
9.4
83
0.13
A0A0A7EMW6A0A0A7EMW6A0A0A7EMW6A0A0A7EMW6
Isoaspartyl peptidase/L-asparaginase
115
Isoaspartyl peptidase/L-asparaginase
202
9.3
102
0.11
ASGL1ASGL1Q7L266Q7L266asparaginecatabolicprocessviaL-aspartateproteolysis
Fibrinogen beta chain
95
Fibrinogen alpha chain
64
9.2
83
0.13
FIBBFIBAP02675P02671adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumionbloodcoagulationcommonpathwaynegativeregulationofbloodcoagulationcommonpathway
NADP-dependent malic enzyme
556
NADP-dependent malic enzyme
556
9.2
48
0.23
MAOXMAOXP48163P48163carbohydratemetabolicprocessmalatemetabolicprocessNADHmetabolicprocessNADPmetabolicprocessnucleotidebiosyntheticprocessproteinhomotetramerizationpyruvatemetabolicprocessregulationofNADPmetabolicprocessresponsetocarbohydrateresponsetohormone
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
222
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
222
9.3
63
0.17
IDH3AIDH3AP50213P50213carbohydratemetabolicprocessisocitratemetabolicprocesstricarboxylicacidcycle
Beta-nerve growth factor
136
Beta-nerve growth factor
231
9.3
85
0.13
NGFNGFP01139P01139activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessadultlocomotorybehavioraxonextensioncircadianrhythmextrinsicapoptoticsignalingpathwayinabsenceofligandextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsmemorymodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnegativeregulationoftypeBpancreaticcellapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwayneuronapoptoticprocessneuronprojectiondevelopmentneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofaxonextensionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofcollateralsproutingpositiveregulationofDNAbindingpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofneurondifferentiationpositiveregulationofneuronmaturationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofneurotrophinTRKreceptorsignalingpathwaypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinautophosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinphosphorylationpositiveregulationofproteinubiquitinationpositiveregulationofRasproteinsignaltransductionpositiveregulationofstemcellproliferationproteinphosphorylationregulationofneurondifferentiationregulationofneurotransmittersecretionregulationofreleaseofsequesteredcalciumionintocytosolsensoryperceptionofpaintransmembranereceptorproteintyrosinekinasesignalingpathway
Gremlin-2
120
Gremlin-2
101
9.3
73
0.15
GREM2GREM2O88273O88273animalorganmorphogenesiscytokine-mediatedsignalingpathwaydeterminationofdorsalidentityembryonicbodymorphogenesisnegativeregulationofBMPsignalingpathwayregulationofcytokineactivitysequesteringofBMPfromreceptorviaBMPbinding
Fibrinogen beta chain
87
Fibrinogen gamma-B chain
33
9.3
64
0.17
FIBBFIBGP02676P12799adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioninnateimmuneresponseplateletaggregationproteinpolymerization
Transforming growth factor beta-2 proprotein
379
Transforming growth factor beta-2 proprotein
346
9.3
87
0.12
TGFB2TGFB2P61812P61812activationofproteinkinaseactivityascendingaortamorphogenesisatrialseptummorphogenesisatrialseptumprimummorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwaycardiacepithelialtomesenchymaltransitioncardiacmusclecellproliferationcardiacrightventriclemorphogenesiscardioblastdifferentiationcelldeathcellmigrationcellmorphogenesiscell-celljunctionorganizationcollagenfibrilorganizationcranialskeletalsystemdevelopmentdopaminebiosyntheticprocessembryodevelopmentendinginbirthoregghatchingembryonicdigestivetractdevelopmentembryoniclimbmorphogenesisendocardialcushionfusionendocardialcushionmorphogenesisepithelialtomesenchymaltransitionextrinsicapoptoticsignalingpathwayeyedevelopmentgenerationofneuronsglialcellmigrationhairfollicledevelopmenthairfolliclemorphogenesisheartdevelopmentheartmorphogenesisheartvalvemorphogenesishemopoiesisinnereardevelopmentkidneydevelopmentmalegonaddevelopmentmembranousseptummorphogenesisnegativeregulationofalkalinephosphataseactivitynegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofepithelialcellproliferationnegativeregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationnegativeregulationofgeneexpressionnegativeregulationofmacrophagecytokineproductionnegativeregulationofRasproteinsignaltransductionneuralretinadevelopmentneuraltubeclosureneurondevelopmentneutrophilchemotaxisodontogenesisoutflowtractseptummorphogenesispathway-restrictedSMADproteinphosphorylationpharyngealarcharterymorphogenesispositiveregulationofcardioblastdifferentiationpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcellcyclepositiveregulationofcelldivisionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationpositiveregulationofheartcontractionpositiveregulationofimmuneresponsepositiveregulationofintegrinbiosyntheticprocesspositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationofNotchsignalingpathwaypositiveregulationofossificationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofstress-activatedMAPKcascadepositiveregulationoftimingofcatagenproteinphosphorylationpulmonaryvalvemorphogenesisregulationofapoptoticprocessinvolvedinoutflowtractmorphogenesisregulationofcellpopulationproliferationregulationoftimingofcatagenregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetoprogesteroneresponsetowoundingresponsetoxenobioticstimulussalivaryglandmorphogenesissecondarypalatedevelopmentskeletalsystemdevelopmentSMADproteinsignaltransductionsomaticstemcelldivisionsubstantiapropriaofcorneadevelopmenttransforminggrowthfactorbetareceptorsignalingpathwayuterinewallbreakdownuterusdevelopmentventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesiswoundhealing
Sequestosome-1
154
Sequestosome-1
154
9.3
66
0.16
SQSTMSQSTMQ13501Q13501aggrephagyapoptoticprocessautophagyautophagyofmitochondrionbrownfatcellproliferationcelldifferentiationendosomaltransportendosomeorganizationenergyhomeostasisimmunesystemprocessintracellularsignaltransductionmacroautophagymitophagynegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofapoptoticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinimportintonucleusproteinlocalizationproteinlocalizationtoperinuclearregionofcytoplasmproteinphosphorylationregulationofI-kappaBkinase/NF-kappaBsignalingregulationofmitochondrionorganizationregulationofproteincomplexstabilityregulationofRasproteinsignaltransductionresponsetoischemiaresponsetomitochondrialdepolarisationselectiveautophagytemperaturehomeostasistranscriptionbyRNApolymeraseIIubiquitin-dependentproteincatabolicprocess
Oxytocin-neurophysin 1
110
Oxytocin-neurophysin 1
105
9.3
92
0.12
NEU1NEU1P01175P01175positiveregulationofcold-inducedthermogenesisresponsetoestrogenresponsetoexternalbioticstimulusresponsetofoodresponsetomechanicalstimulus
Protein kinase C delta type
261
Protein kinase C delta type
247
9.3
58
0.19
A0A140UHX0A0A140UHX0A0A140UHX0A0A140UHX0apoptoticprocesscellcycleproteinphosphorylation
Importin-4
708
Importin-4
735
9.3
34
0.32
IPO4IPO4Q8TEX9Q8TEX9DNAreplication-dependentchromatinassemblyDNAreplication-independentchromatinassemblyproteinimportintonucleus
Probable ATP-dependent RNA helicase DDX6
385
Probable ATP-dependent RNA helicase DDX6
361
9.3
79
0.14
DDX6DDX6P26196P26196miRNA-mediatedgenesilencingbyinhibitionoftranslationnegativeregulationofneurondifferentiationnegativeregulationoftranslationneurondifferentiationP-bodyassemblystemcellpopulationmaintenancestressgranuleassemblyviralRNAgenomepackaging
Resistin-like beta
49
Resistin-like beta
49
9.3
71
0.15
RETNBRETNBQ99P86Q99P86responsetobacterium
Vascular endothelial growth factor C
166
Vascular endothelial growth factor C
156
9.3
79
0.14
VEGFCVEGFCP49767P49767animalorganmorphogenesiscellularresponsetoleukemiainhibitoryfactorglialcellproliferationinductionofpositivechemotaxismorphogenesisofembryonicepitheliumnegativeregulationofbloodpressurenegativeregulationofosteoblastdifferentiationpositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellproliferationpositiveregulationofglialcellproliferationpositiveregulationoflymphangiogenesispositiveregulationofmastcellchemotaxispositiveregulationofmesenchymalstemcellproliferationpositiveregulationofneuroblastproliferationpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayresponsetohypoxiaresponsetoxenobioticstimulussignaltransductionsproutingangiogenesissubstrate-dependentcellmigrationvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathway
Mothers against decapentaplegic homolog 2
349
Zinc finger FYVE domain-containing protein 9
783
9.3
75
0.14
SMAD2ZFYV9Q15796O95405activinreceptorsignalingpathwayadrenalglanddevelopmentanatomicalstructuremorphogenesisanterior/posteriorpatternspecificationBMPsignalingpathwaycelldifferentiationcellfatecommitmentcommon-partnerSMADproteinphosphorylationembryoniccranialskeletonmorphogenesisembryonicforegutmorphogenesisendodermformationgastrulationinuteroembryonicdevelopmentinsulinsecretionintracellularsignaltransductionlungdevelopmentmesodermformationnegativeregulationofcellpopulationproliferationnegativeregulationoftranscriptionDNA-templatednodalsignalingpathwayorgangrowthpancreasdevelopmentparaxialmesodermmorphogenesispericardiumdevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofgeneexpressionpositiveregulationofnodalsignalingpathwayinvolvedindeterminationoflateralmesodermleft/rightasymmetrypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpost-embryonicdevelopmentprimarymiRNAprocessingregulationofbindingregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoglucosesecondarypalatedevelopmentsignaltransductioninvolvedinregulationofgeneexpressionSMADproteincomplexassemblySMADproteinsignaltransductiontranscriptionDNA-templatedtransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentwoundhealingzygoticspecificationofdorsal/ventralaxisendocytosisendosomaltransport
Inhibin beta A chain
390
Inhibin beta A chain
425
9.3
62
0.17
INHBAINHBAP08476P08476activinreceptorsignalingpathwaycelldifferentiationcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularresponsetocholesterolcellularresponsetofollicle-stimulatinghormonestimulusdefenseresponseendodermalcelldifferentiationerythrocytedifferentiationextrinsicapoptoticsignalingpathwayeyeliddevelopmentincamera-typeeyeGABAergicneurondifferentiationhairfollicledevelopmenthematopoieticprogenitorcelldifferentiationhemoglobinbiosyntheticprocessmalegonaddevelopmentmesodermalcelldifferentiationmulticellularorganismagingnegativeregulationofBcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationoffollicle-stimulatinghormonesecretionnegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofinterferon-gammaproductionnegativeregulationofmacrophagedifferentiationnegativeregulationofphosphorylationnervoussystemdevelopmentodontogenesisovarianfollicledevelopmentpositiveregulationoferythrocytedifferentiationpositiveregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandpositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofgeneexpressionpositiveregulationofovulationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprogesteronesecretionregulationoffollicle-stimulatinghormonesecretionregulationoftranscriptionbyRNApolymeraseIIresponsetoxenobioticstimulusroofofmouthdevelopmentSMADproteinsignaltransductionstriatalmediumspinyneurondifferentiationtranscriptionbyRNApolymeraseII
Defensin-6
74
Defensin-6
88
9.3
64
0.17
DEF6DEF6Q01524Q01524antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosakillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Vascular endothelial growth factor B
47
Vascular endothelial growth factor B
72
9.3
74
0.15
VEGFBVEGFBP49765P49765cardiacmusclecontractioncoronaryvasculaturedevelopmentinductionofpositivechemotaxisnegativeregulationofapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofneuronapoptoticprocesspositiveregulationofangiogenesispositiveregulationofcelldivisionpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofmastcellchemotaxispositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofvascularwoundhealingproteinO-linkedglycosylationresponsetohypoxiasproutingangiogenesisvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathway
NAD-capped RNA hydrolase NUDT12
387
NAD-capped RNA hydrolase NUDT12
400
9.3
84
0.13
NUD12NUD12Q9BQG2Q9BQG2circadianregulationofgeneexpressionmethylguanosine-capdecappingmRNAcatabolicprocessNADbiosynthesisvianicotinamideribosidesalvagepathwayNADcatabolicprocessNAD-capdecappingNADHmetabolicprocessNADPcatabolicprocess
Poly [ADP-ribose] polymerase tankyrase-1
1242
Poly [ADP-ribose] polymerase tankyrase-1
1242
9.3
63
0.17
TNKS1TNKS1O95271O95271celldivisionmitoticspindleorganizationmRNAtransportnegativeregulationofmaintenanceofmitoticsisterchromatidcohesiontelomericnegativeregulationoftelomeremaintenanceviatelomerelengtheningnegativeregulationoftelomericDNAbindingpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationoftelomeraseactivitypositiveregulationoftelomerecappingpositiveregulationoftelomeremaintenanceviatelomerasepositiveregulationoftranscriptionbyRNApolymeraseIIproteinADP-ribosylationproteinauto-ADP-ribosylationproteinlocalizationtochromosometelomericregionproteinpoly-ADP-ribosylationproteinpolyubiquitinationproteintransportregulationoftelomeremaintenanceviatelomerasespindleassemblyWntsignalingpathway
Serine/threonine-protein kinase/endoribonuclease IRE1
630
Serine/threonine-protein kinase/endoribonuclease IRE1
630
9.3
75
0.14
ERN1ERN1O75460O75460cellularresponsetoglucosestimuluscellularresponsetohydrogenperoxidecellularresponsetounfoldedproteincellularresponsetovascularendothelialgrowthfactorstimulusendothelialcellproliferationinsulinmetabolicprocessintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressIRE1-mediatedunfoldedproteinresponsemRNAcatabolicprocessmRNAcleavagemRNAcleavageinvolvedinmRNAprocessingmRNAsplicingviaendonucleolyticcleavageandligationpeptidyl-serineautophosphorylationpeptidyl-serinetrans-autophosphorylationpositiveregulationofendoplasmicreticulumunfoldedproteinresponsepositiveregulationofJUNkinaseactivitypositiveregulationofRNAsplicingpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinautophosphorylationproteinphosphorylationregulationofmacroautophagyresponsetoendoplasmicreticulumstress
Ephrin type-A receptor 4
118
Ephrin type-A receptor 4
108
9.3
83
0.13
EPHA4EPHA4P54764P54764adherensjunctionorganizationadultwalkingbehavioraxonguidancecelladhesioncellularresponsetoamyloid-betacochleadevelopmentcorticospinaltractmorphogenesisephrinreceptorsignalingpathwayfasciculationofmotorneuronaxonfasciculationofsensoryneuronaxonglialcellmigrationmotorneuronaxonguidancenegativeregulationofaxonregenerationnegativeregulationofcelladhesionnegativeregulationofcellmigrationnegativeregulationofcellularresponsetohypoxianegativeregulationofepithelialtomesenchymaltransitionnegativeregulationofERK1andERK2cascadenegativeregulationoflong-termsynapticpotentiationnegativeregulationofneuronprojectiondevelopmentnegativeregulationofproteolysisinvolvedinproteincatabolicprocessnephricductmorphogenesisneuronprojectionfasciculationneuronprojectionguidancepeptidyl-tyrosinephosphorylationpositiveregulationofamyloid-betaformationpositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdendritemorphogenesispositiveregulationofJUNkinaseactivitypositiveregulationofkinaseactivitypositiveregulationofproteintyrosinekinaseactivitypositiveregulationofRhoguanyl-nucleotideexchangefactoractivityproteinautophosphorylationproteinstabilizationregulationofastrocytedifferentiationregulationofaxonogenesisregulationofdendriticspinemorphogenesisregulationofGTPaseactivityregulationofmodificationofsynapticstructuresynapsepruningtransmembranereceptorproteintyrosinekinasesignalingpathway
A disintegrin and metalloproteinase with thrombospondin motifs 4
460
A disintegrin and metalloproteinase with thrombospondin motifs 4
482
9.3
70
0.15
ATS4ATS4O75173O75173extracellularmatrixdisassemblyextracellularmatrixorganizationproteolysisskeletalsystemdevelopment
APOBEC3H
85
APOBEC3H
116
9.3
64
0.17
B7TQM6B7TQM6B7TQM6B7TQM6
Tumor necrosis factor ligand superfamily member 13B
245
Tumor necrosis factor ligand superfamily member 13B
245
9.2
101
0.11
TN13BTN13BQ9Y275Q9Y275BcellcostimulationBcelldifferentiationBcellhomeostasisBcellproliferationgerminalcenterformationpositiveregulationofBcellproliferationpositiveregulationofgerminalcenterformationpositiveregulationofTcellproliferationsignaltransductionTcellcostimulationTcellproliferationtumornecrosisfactor-mediatedsignalingpathway
Histo-blood group ABO system transferase
80
Histo-blood group ABO system transferase
80
9.2
68
0.16
BGATBGATP16442P16442carbohydratemetabolicprocesslipidglycosylationproteinglycosylation
Platelet factor 4 variant
86
Platelet factor 4 variant
86
9.2
68
0.16
PF4VPF4VP10720P10720antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwayinflammatoryresponseneutrophilchemotaxisplateletactivation
Glutamate receptor 2
330
Glutamate receptor 2
330
9.2
72
0.15
GRIA2GRIA2P19491P19491chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumion
Platelet-derived growth factor subunit B
124
Platelet-derived growth factor subunit B
134
9.2
68
0.16
PDGFBPDGFBP01127P01127activationofproteinkinaseactivityactivationofproteinkinaseBactivitycellchemotaxiscellularresponsetogrowthfactorstimuluscellularresponsetomycophenolicacidcellularresponsetoplatelet-derivedgrowthfactorstimulusembryonicplacentadevelopmentheartdevelopmentinterleukin-18-mediatedsignalingpathwaymetanephricglomerularmesangialcelldevelopmentmonocytechemotaxisnegativeregulationofgeneexpressionnegativeregulationofmiRNAtranscriptionnegativeregulationofphosphatidylinositolbiosyntheticprocessnegativeregulationofplateletactivationnegativeregulationofproteinbindingnegativeregulationoftranscriptionDNA-templatednegativeregulationofvascularassociatedsmoothmusclecelldifferentiationparacrinesignalingpeptidyl-serinephosphorylationpeptidyl-tyrosinephosphorylationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcalciumionimportpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-substrateadhesionpositiveregulationofchemotaxispositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglomerularfiltrationpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofhyaluronanbiosyntheticprocesspositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmetanephricmesenchymalcellmigrationpositiveregulationofmetanephricmesenchymalcellmigrationbyplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofmiRNAtranscriptionpositiveregulationofmitoticnucleardivisionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularassociatedsmoothmusclecelldedifferentiationpositiveregulationofvascularassociatedsmoothmusclecellmigrationpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseCsignalingproteinphosphorylationreactiveoxygenspeciesmetabolicprocessresponsetowounding
Suppressor of tumorigenicity 14 protein
641
Pancreatic trypsin inhibitor
49
9.2
97
0.11
ST14BPT1Q9Y5Y6P00974epithelialcellmorphogenesisinvolvedinplacentalbranchingkeratinocytedifferentiationneuraltubeclosureproteincatabolicprocessproteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Neuroblastoma suppressor of tumorigenicity 1
63
Neuroblastoma suppressor of tumorigenicity 1
123
9.2
72
0.15
NBL1NBL1P41271P41271animalorganmorphogenesisdeterminationofdorsalidentitynegativeregulationofBMPsignalingpathwaynegativeregulationofmonocytechemotaxisnervoussystemdevelopmentneuronprojectionmorphogenesispositiveregulationofneurondifferentiationsequesteringofBMPfromreceptorviaBMPbindingsequesteringofBMPinextracellularmatrix
Fibrinogen gamma chain
49
Fibrinogen gamma chain
45
9.2
81
0.13
FIBGFIBGP02679P02679bloodcoagulationfibrinclotformationcell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetointerleukin-6fibrinolysisnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofplateletaggregationplasminogenactivationplateletaggregationplateletmaturationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationproteinsecretionprotein-containingcomplexassemblyresponsetocalciumion
Ornithine decarboxylase
360
Ornithine decarboxylase
114
9.3
84
0.13
DCORDCORP11926P11926cellpopulationproliferationkidneydevelopmentpolyaminemetabolicprocesspositiveregulationofcellpopulationproliferationputrescinebiosyntheticprocessfromornithineregulationofproteincatabolicprocessresponsetovirus
Kelch-like ECH-associated protein 1
518
Kelch-like ECH-associated protein 1
489
9.3
74
0.15
KEAP1KEAP1Q14145Q14145cellularresponsetointerleukin-4cellularresponsetooxidativestresscytoplasmicsequesteringoftranscriptionfactorinuteroembryonicdevelopmentnegativeregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteinubiquitinationregulationofautophagyregulationofepidermalcelldifferentiationubiquitin-dependentproteincatabolicprocess
Fibrinogen beta chain
316
Fibrinogen gamma chain
165
9.3
72
0.15
FIBBFIBGP02675P02679adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Guanine nucleotide-binding protein G(i) subunit alpha-3
305
Guanine nucleotide-binding protein G(i) subunit alpha-3
305
9.3
49
0.22
GNAI3GNAI3P08754P08754adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaybraindevelopmentcellcyclecelldivisiondopaminereceptorsignalingpathwayGTPmetabolicprocessnegativeregulationofadenylatecyclaseactivitynegativeregulationofapoptoticsignalingpathwaypositiveregulationofmacroautophagypositiveregulationofNAD(P)Hoxidaseactivitypositiveregulationofsuperoxideaniongenerationpositiveregulationofvascularassociatedsmoothmusclecellproliferationvesiclefusion
Mothers against decapentaplegic homolog 4
401
Ski-like protein
327
9.3
71
0.15
SMAD4SKILQ13485P12757activinreceptorsignalingpathwayadrenalglanddevelopmentaginganatomicalstructuremorphogenesisatrioventricularcanaldevelopmentatrioventricularvalveformationaxonguidanceBMPsignalingpathwaybrainstemdevelopmentbranchinginvolvedinuretericbudmorphogenesiscardiacconductionsystemdevelopmentcelldifferentiationcellpopulationproliferationcellularironionhomeostasiscellularresponsetoBMPstimuluscellularresponsetoglucosestimulusdevelopmentalgrowthembryonicdigitmorphogenesisendocardialcelldifferentiationendothelialcellactivationepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationERK1andERK2cascadefemalegonadmorphogenesisformationofanatomicalboundarygastrulationwithmouthformingsecondinuteroembryonicdevelopmentinterleukin-6-mediatedsignalingpathwayintracellularsignaltransductionleftventricularcardiacmuscletissuemorphogenesismesendodermdevelopmentmetanephricmesenchymemorphogenesisnegativeregulationofcardiacmusclehypertrophynegativeregulationofcardiacmyofibrilassemblynegativeregulationofcelldeathnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofERK1andERK2cascadenegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednephrogenicmesenchymemorphogenesisneuralcrestcelldifferentiationneuronfatecommitmentosteoblastdifferentiationoutflowtractseptummorphogenesisovarianfollicledevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcellproliferationinvolvedinheartvalvemorphogenesispositiveregulationofepithelialtomesenchymaltransitionpositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofhistoneH3-K4methylationpositiveregulationofhistoneH3-K9acetylationpositiveregulationofluteinizinghormonesecretionpositiveregulationofmiRNAtranscriptionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimuluspositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationofbindingregulationofhairfollicledevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetotransforminggrowthfactorbetasebaceousglanddevelopmentsecondarypalatedevelopmentseminiferoustubuledevelopmentsinglefertilizationSMADproteincomplexassemblySMADproteinsignaltransductionsomiterostral/caudalaxisspecificationspermatogenesistranscriptionbyRNApolymeraseIItranscriptionDNA-templatedtransforminggrowthfactorbetareceptorsignalingpathwayuterusdevelopmentventricularseptummorphogenesiswoundhealingblastocystformationextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagelensfibercelldifferentiationlymphocytehomeostasisnegativeregulationofBMPsignalingpathwaynegativeregulationofcelldifferentiationnegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofaxonogenesispositiveregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorspositiveregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageregulationofcellcycleresponsetoantibioticresponsetocytokineresponsetogrowthfactorskeletalmuscletissuedevelopment
Fatty acid-binding protein 5
47
Fatty acid-binding protein 5
87
9.3
60
0.18
FABP5FABP5Q01469Q01469epidermisdevelopmentfattyacidtransportglucosehomeostasisglucosemetabolicprocesslipidmetabolicprocesslipidtransportacrossblood-brainbarrierlong-chainfattyacidtransportnegativeregulationofglucosetransmembranetransportphosphatidylcholinebiosyntheticprocesspositiveregulationofcold-inducedthermogenesispositiveregulationofperoxisomeproliferatoractivatedreceptorsignalingpathwayregulationofprostaglandinbiosyntheticprocessregulationofretrogradetrans-synapticsignalingbyendocanabinoidregulationofsensoryperceptionofpain
Fibrinogen beta chain
223
Fibrinogen gamma chain
165
9.3
70
0.15
FIBBFIBGP02675P02679adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Gremlin-1
141
Gremlin-1
144
9.2
80
0.14
GREM1GREM1O60565O60565animalorganmorphogenesisapoptoticprocesscardiacmusclecelldifferentiationcardiacmusclecellmyoblastdifferentiationcellmigrationinvolvedinsproutingangiogenesiscellmorphogenesiscell-cellsignalingcollagenfibrilorganizationdeterminationofdorsalidentityembryoniclimbmorphogenesislimbdevelopmentmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesisnegativeregulationofapoptoticprocessnegativeregulationofBMPsignalingpathwaynegativeregulationofbonemineralizationnegativeregulationofbonemineralizationinvolvedinbonematurationnegativeregulationofboneremodelingnegativeregulationofbonetrabeculaformationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellgrowthnegativeregulationofchondrocytedifferentiationnegativeregulationofmonocytechemotaxisnegativeregulationofosteoblastdifferentiationnegativeregulationofosteoblastproliferationnegativeregulationofosteoclastproliferationnegativeregulationofpathway-restrictedSMADproteinphosphorylationnegativeregulationoftranscriptionDNA-templatedpositiveregulationofangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcellpopulationproliferationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofreceptorinternalizationpositiveregulationofsignalingreceptoractivitypositiveregulationoftelomeraseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIproximal/distalpatternformationregulationofepithelialtomesenchymaltransitionregulationoffocaladhesionassemblysequesteringofBMPfromreceptorviaBMPbindingsignaltransductionuretericbudformation
DNA (cytosine-5)-methyltransferase 3A
562
DNA (cytosine-5)-methyltransferase 3A
514
9.2
82
0.13
DNM3ADNM3AQ9Y6K1Q9Y6K1agingC-5methylationofcytosinecellularresponsetoaminoacidstimuluscellularresponsetobisphenolAcellularresponsetoethanolcellularresponsetohypoxiaDNAmethylationDNAmethylationinvolvedinembryodevelopmentDNAmethylationinvolvedingametegenerationDNAmethylationoncytosineDNAmethylation-dependentheterochromatinassemblyhepatocyteapoptoticprocessmitoticcellcyclenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneurondifferentiationpositiveregulationofcelldeathregulationofgeneexpressionbygenomicimprintingresponsetococaineresponsetoestradiolresponsetoionizingradiationresponsetoleadionresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulusspermatogenesis
Ketohexokinase
32
Ketohexokinase
98
9.2
74
0.15
KHKKHKP50053P50053fructosemetabolicprocessregulationofglycogenmetabolicprocessresponsetofructoseresponsetoglucoseresponsetoinsulinresponsetosucroseresponsetozincion
Cellular tumor antigen p53
173
Cellular tumor antigen p53
173
9.2
66
0.17
P53P53P02340P02340apoptoticprocessautophagyBcelllineagecommitmentbonemarrowdevelopmentcardiacmusclecellapoptoticprocesscardiacseptummorphogenesiscellpopulationproliferationcellularresponsetoactinomycinDcellularresponsetoDNAdamagestimuluscellularresponsetogammaradiationcellularresponsetoglucosestarvationcellularresponsetoionizingradiationcellularresponsetoreactiveoxygenspeciescellularresponsetoUVcellularresponsetoUV-CcellularresponsetoxenobioticstimuluscellularsenescencecentralnervoussystemdevelopmentcerebellumdevelopmentchromatinassemblychromosomeorganizationcircadianbehaviorcircadianrhythmdeterminationofadultlifespanDNAdamageresponsesignaltransductionbyp53classmediatorDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestDNAdamageresponsesignaltransductionbyp53classmediatorresultingintranscriptionofp21classmediatordouble-strandbreakrepairembryodevelopmentendinginbirthoregghatchingembryonicorgandevelopmententrainmentofcircadianclockbyphotoperiodERoverloadresponsefibroblastproliferationgastrulationglialcellproliferationglucosecatabolicprocesstolactateviapyruvateheartdevelopmenthematopoieticprogenitorcelldifferentiationhematopoieticstemcelldifferentiationinuteroembryonicdevelopmentinterferon-gamma-mediatedsignalingpathwayintrinsicapoptoticsignalingpathwaybyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressintrinsicapoptoticsignalingpathwayinresponsetohypoxiamitochondrialDNArepairmitophagymitoticG1DNAdamagecheckpointsignalingmRNAtranscriptionmulticellularorganismgrowthnecroptoticprocessnegativeregulationofapoptoticprocessnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofDNAbiosyntheticprocessnegativeregulationofDNAreplicationnegativeregulationoffibroblastproliferationnegativeregulationofG1toG0transitionnegativeregulationofgeneexpressionnegativeregulationofglialcellproliferationnegativeregulationofglucosecatabolicprocesstolactateviapyruvatenegativeregulationofmiRNAmaturationnegativeregulationofmitophagynegativeregulationofmitoticcellcyclenegativeregulationofneuroblastproliferationnegativeregulationofpentose-phosphateshuntnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofsmoothmusclecellproliferationnegativeregulationofstemcellproliferationnegativeregulationoftelomeraseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayneuroblastproliferationneuronapoptoticprocessnucleotide-excisionrepairoligodendrocyteapoptoticprocessoxidativestress-inducedprematuresenescencepositiveregulationofapoptoticprocesspositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcellcyclepositiveregulationofcellularsenescencepositiveregulationofexecutionphaseofapoptosispositiveregulationofgeneexpressionpositiveregulationofhistonedeacetylationpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofleukocytemigrationpositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofmitochondrialmembranepermeabilitypositiveregulationofneuronapoptoticprocesspositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofprogrammednecroticcelldeathpositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofreleaseofcytochromecfrommitochondriapositiveregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblypositiveregulationofthymocyteapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoendoplasmicreticulumstresspositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetostresspositiveregulationoftranscriptionDNA-templatedproteinimportintonucleusproteinlocalizationproteinstabilizationproteintetramerizationprotein-containingcomplexassemblyRasproteinsignaltransductionreactiveoxygenspeciesmetabolicprocessregulationofapoptoticprocessregulationofcellcycleregulationofcellcycleG2/MphasetransitionregulationofcellpopulationproliferationregulationofcellularsenescenceregulationofDNAdamageresponsesignaltransductionbyp53classmediatorregulationoffibroblastapoptoticprocessregulationofhydrogenperoxide-inducedcelldeathregulationofintracellularpHregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorregulationofmitochondrialmembranepermeabilityinvolvedinapoptoticprocessregulationofmitoticcellcycleregulationofneuronapoptoticprocessregulationofthymocyteapoptoticprocessregulationoftissueremodelingregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoDNAdamageregulationoftranscriptionDNA-templatedreleaseofcytochromecfrommitochondriareplicativesenescenceresponsetogammaradiationresponsetoischemiaresponsetooxidativestressresponsetosaltstressresponsetoUVresponsetoX-rayresponsetoxenobioticstimulusrRNAtranscriptionsignaltransductionbyp53classmediatorsomitogenesisspermatogenesisstemcellproliferationTcelldifferentiationinthymusTcelllineagecommitmentTcellproliferationinvolvedinimmuneresponsethymocyteapoptoticprocesstransforminggrowthfactorbetareceptorsignalingpathwaytumornecrosisfactor-mediatedsignalingpathwayviralprocess
Properdin
127
Properdin
455
9.2
66
0.16
PROPPROPP27918P27918complementactivationcomplementactivationalternativepathwaydefenseresponsetobacteriumimmuneresponsepositiveregulationofimmuneresponsepositiveregulationofopsonization
Recombining binding protein suppressor of hairless
397
Mastermind-like protein 1
37
9.3
77
0.14
SUHMAML1Q06330Q92585angiogenesisaorticvalvedevelopmentarterialendothelialcellfatecommitmentatrioventricularcanaldevelopmentauditoryreceptorcellfatecommitmentBcelldifferentiationbloodvesselendothelialcellfatespecificationbloodvessellumenizationbloodvesselremodelingcardiacleftventriclemorphogenesiscardiacmusclecellmyoblastdifferentiationclubcelldifferentiationdefenseresponsetobacteriumdorsalaortamorphogenesisendocardiummorphogenesisepidermalcellfatespecificationepithelialcellproliferationepithelialtomesenchymaltransitionepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationhairfolliclematurationhumoralimmuneresponseinflammatoryresponsetoantigenicstimuluskeratinocytedifferentiationlabyrinthinelayerbloodvesseldevelopmentmyeloiddendriticcelldifferentiationnegativeregulationofcelldifferentiationnegativeregulationofcold-inducedthermogenesisnegativeregulationofossificationnegativeregulationofstemcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedNotchsignalinginvolvedinheartdevelopmentNotchsignalingpathwayoutflowtractmorphogenesispituitaryglanddevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofcanonicalWntsignalingpathwayinvolvedincardiacmusclecellfatecommitmentpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellproliferationinvolvedinheartmorphogenesispositiveregulationofephrinreceptorsignalingpathwaypositiveregulationofepithelialcellproliferationpositiveregulationofERBBsignalingpathwaypositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionofNotchreceptortargetpulmonaryvalvedevelopmentregulationofreproductiveprocessregulationoftimingofcelldifferentiationregulationoftranscriptionbyRNApolymeraseIIsebaceousglanddevelopmentsecondaryheartfieldspecificationsomaticstemcellpopulationmaintenancesomitogenesisstemcellproliferationventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesisatrioventricularnodecelldevelopmentatrioventricularnodedevelopmentmyoblastdifferentiationpositiveregulationofmyotubedifferentiationproteinphosphorylation
Ribonuclease pancreatic
93
Ribonuclease inhibitor
409
9.2
65
0.17
RNAS1RINIP07998P13489defenseresponsetoGram-positivebacteriumRNAphosphodiesterbondhydrolysismRNAcatabolicprocessregulationofangiogenesis
Serotransferrin
198
Serotransferrin
58
9.3
88
0.12
TRFETRFEP02787P02787actinfilamentorganizationantibacterialhumoralresponsecellularironionhomeostasiscellularresponsetoironionERK1andERK2cascadeironionhomeostasisironiontransportosteoclastdifferentiationpositiveregulationofboneresorptionpositiveregulationofcellmotilitypositiveregulationofphosphorylationpositiveregulationofreceptor-mediatedendocytosispositiveregulationoftranscriptionDNA-templatedregulationofironiontransportregulationofproteinstabilityretinahomeostasisSMADproteinsignaltransduction
Glycoprotein hormones alpha chain
111
Follitropin subunit beta
50
9.3
78
0.14
Q96QJ4FSHBQ96QJ4P01225femalegametegenerationfemalepregnancyfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwaypositiveregulationofboneresorptionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationregulationofsignalingreceptoractivitySertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
COP9 signalosome complex subunit 4
378
COP9 signalosome complex subunit 7a
181
9.3
75
0.14
CSN4CSN7AQ9BT78Q9UBW8proteindeneddylationproteinneddylationregulationofproteinneddylationCOP9signalosomeassembly
Fibrinogen alpha chain
180
Fibrinogen gamma chain
165
9.2
82
0.13
FIBAFIBGP02671Q53Y18adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-1cellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Cullin-5
188
Cullin-5
188
9.2
66
0.16
CUL5CUL5Q93034Q93034ERBB2signalingpathwayG1/StransitionofmitoticcellcycleintrinsicapoptoticsignalingpathwayproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocess
Progesterone receptor
619
Progesterone receptor
619
9.2
79
0.14
PRGRPRGRP06401P06401cell-cellsignalingglandularepithelialcellmaturationintracellularsteroidhormonereceptorsignalingpathwaylungalveolusdevelopmentnegativeregulationofgeneexpressionovulationfromovarianfollicleparacrinesignalingpositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronereceptorsignalingpathwayregulationofepithelialcellproliferationregulationoftranscriptionbyRNApolymeraseIIsignaltransductiontertiarybranchinginvolvedinmammaryglandductmorphogenesis
Glutamate receptor 3
85
Glutamate receptor 3
85
9.2
65
0.17
GRIA3GRIA3P19492P19492regulationofreceptorrecyclingresponsetofungicideresponsetolithiumion
Transforming growth factor beta-1 proprotein
356
Transforming growth factor beta-1 proprotein
355
9.2
75
0.15
TGFB1TGFB1P01137P01137aorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaycellmigrationcell-celljunctionorganizationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluschondrocytedifferentiationcommon-partnerSMADproteinphosphorylationconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingembryonicliverdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayheartdevelopmentheartvalvemorphogenesishematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphnodedevelopmentmacrophagederivedfoamcelldifferentiationMAPKcascademembraneproteinintracellulardomainproteolysisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofcytolysisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixdisassemblynegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofmacrophagecytokineproductionnegativeregulationofmiRNAmaturationnegativeregulationofmiRNAtranscriptionnegativeregulationofmiRNA-mediatedgenesilencingnegativeregulationofmyoblastdifferentiationnegativeregulationofproteinlocalizationtoplasmamembranenegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationoftranscriptionDNA-templatedneuraltubeclosureneuraltubedevelopmentossificationinvolvedinboneremodelingpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixassemblypositiveregulationoffibroblastmigrationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationofSMADproteinsignaltransductionpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularpermeabilityproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofbindingregulationofbloodvesselremodelingregulationofcellmigrationregulationofcellpopulationproliferationregulationofDNAbindingregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
Glutamate receptor 2
330
Glutamate receptor 2
78
9.2
78
0.14
GRIA2GRIA2P19491P19491chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumion
Glutamate receptor 1
323
Glutamate receptor 1
75
9.2
80
0.14
GRIA1GRIA1P19490P19490cellularresponsetoaminestimuluscellularresponsetoaminoacidstimuluscellularresponsetoammoniumioncellularresponsetodsRNAcellularresponsetogrowthfactorstimuluscellularresponsetoorganiccycliccompoundcellularresponsetopeptidehormonestimuluschemicalsynaptictransmissionlong-termmemorylong-termsynapticdepressionmodulationofchemicalsynaptictransmissionneuronalactionpotentialpositiveregulationofmembranepotentialpositiveregulationofsynaptictransmissionreceptorinternalizationregulationofpostsynapticmembranepotentialregulationofreceptorrecyclingregulationofsynapticplasticityresponsetoarsenic-containingsubstanceresponsetococaineresponsetoelectricalstimulusresponsetoestradiolresponsetofungicideresponsetolithiumionresponsetoorganiccycliccompoundresponsetopeptidehormoneresponsetotoxicsubstanceresponsetoxenobioticstimulusspinalcorddevelopmentsynaptictransmissionglutamatergic
N-acetyltransferase ESCO1
758
N-acetyltransferase ESCO1
757
9.2
86
0.13
ESCO1ESCO1Q5FWF5Q5FWF5mitoticsisterchromatidcohesionpeptidyl-lysineacetylationpost-translationalproteinacetylationregulationofDNAreplication
Vascular endothelial growth factor A
130
Vascular endothelial growth factor A
77
9.2
60
0.18
VEGFAVEGFAP15692P15692activationofproteinkinaseactivityangiogenesisarterymorphogenesisbasophilchemotaxisbranchinginvolvedinbloodvesselmorphogenesiscamera-typeeyemorphogenesiscardiacmusclecelldevelopmentcardiacvascularsmoothmusclecelldevelopmentcellmaturationcellmigrationinvolvedinsproutingangiogenesiscellularresponsetohypoxiacellularresponsetovascularendothelialgrowthfactorstimuluscellularstressresponsetoacidchemicalcommissuralneuronaxonguidancecoronaryarterymorphogenesiscoronaryveinmorphogenesisdopaminergicneurondifferentiationendothelialcellchemotaxisepithelialcelldifferentiationeyephotoreceptorcelldevelopmentheartmorphogenesisinuteroembryonicdevelopmentinductionofpositivechemotaxiskidneydevelopmentlactationlungdevelopmentlymphvesselmorphogenesismacrophagedifferentiationmammaryglandalveolusdevelopmentmesodermdevelopmentmonocytedifferentiationmotorneuronmigrationnegativeregulationofadherensjunctionorganizationnegativeregulationofapoptoticprocessnegativeregulationofblood-brainbarrierpermeabilitynegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofestablishmentofendothelialbarriernegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentoutflowtractmorphogenesisovarianfollicledevelopmentpositivechemotaxispositiveregulationofangiogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelladhesionpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellmigrationbyvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofcellproliferationbyVEGF-activatedplateletderivedgrowthfactorreceptorsignalingpathwaypositiveregulationofcold-inducedthermogenesispositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialtubeformationpositiveregulationofERK1andERK2cascadepositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofhistonedeacetylaseactivitypositiveregulationofleukocytemigrationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmastcellchemotaxispositiveregulationofneuroblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofpositivechemotaxispositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinkinaseCsignalingpositiveregulationofproteinkinaseDsignalingpositiveregulationofproteinlocalizationtoearlyendosomepositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorinternalizationpositiveregulationofretinalganglioncellaxonguidancepositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftrophoblastcellmigrationpositiveregulationofvascularpermeabilitypost-embryoniccamera-typeeyedevelopmentprimitiveerythrocytedifferentiationregulationofcellshaperegulationofnitricoxidemediatedsignaltransductionregulationofretinalganglioncellaxonguidanceregulationoftranscriptionbyRNApolymeraseIIresponsetohypoxiasproutingangiogenesissurfactanthomeostasistubeformationvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorreceptor-2signalingpathwayvascularendothelialgrowthfactorsignalingpathwayvascularwoundhealingvasculogenesisVEGF-activatedneuropilinsignalingpathway
Nitric oxide synthase, brain
326
Nitric oxide synthase, brain
326
4.0
68
0.37
NOS1NOS1P29476P29476agingargininecatabolicprocessbehavioralresponsetococainebraindevelopmentcellularresponsetoepinephrinestimuluscellularresponsetogrowthfactorstimuluscellularresponsetomechanicalstimulusestablishmentofproteinlocalizationfemalepregnancymulticellularorganismalresponsetostressmusclecontractionnegativeregulationofapoptoticprocessnegativeregulationofbloodpressurenegativeregulationofcalciumiontransportnegativeregulationofcellpopulationproliferationnegativeregulationofcytosoliccalciumionconcentrationnegativeregulationofheartcontractionnegativeregulationofhepaticstellatecellcontractionnegativeregulationofhydrolaseactivitynegativeregulationofinsulinsecretionnegativeregulationofironiontransmembranetransportnegativeregulationofneuronapoptoticprocessnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofpotassiumiontransportnegativeregulationofserotoninuptakenegativeregulationofvasoconstrictionnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionpeptidyl-cysteineS-nitrosylationpositiveregulationofadenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocesspositiveregulationofguanylatecyclaseactivitypositiveregulationofhistoneacetylationpositiveregulationoflong-termsynapticpotentiationpositiveregulationofneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsodiumiontransmembranetransportpositiveregulationoftheforceofheartcontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofheartcontractionregulationofneurogenesisregulationofsensoryperceptionofpainregulationofsodiumiontransportresponsetoactivityresponsetoestrogenresponsetoethanolresponsetoheatresponsetohormoneresponsetohypoxiaresponsetoleadionresponsetolipopolysaccharideresponsetonicotineresponsetonitricoxideresponsetonutrientlevelsresponsetoorganiccycliccompoundresponsetoorganonitrogencompoundresponsetopeptidehormoneresponsetovitaminEretrogradetrans-synapticsignalingbynitricoxidestriatedmusclecontractionsynapticsignalingbynitricoxidevasodilationxenobioticcatabolicprocess
Indoleamine 2,3-dioxygenase 1
308
Indoleamine 2,3-dioxygenase 1
308
4.9
69
0.3
I23O1I23O1P14902P14902"denovoNADbiosyntheticprocessfromtryptophan"femalepregnancyinflammatoryresponsekynurenicacidbiosyntheticprocessmulticellularorganismalresponsetostressnegativeregulationofinterleukin-10productionnegativeregulationofTcellapoptoticprocessnegativeregulationofTcellproliferationpositiveregulationofchronicinflammatoryresponsepositiveregulationofinterleukin-12productionpositiveregulationofTcellapoptoticprocesspositiveregulationofTcelltoleranceinductionpositiveregulationoftype2immuneresponseresponsetolipopolysaccharideswimmingbehaviorTcellproliferationtryptophancatabolicprocesstryptophancatabolicprocesstokynurenine
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
193
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
193
4.9
78
0.26
Q9TTF5Q9TTF5Q9TTF5Q9TTF5metabolicprocess
Interleukin-1 receptor-associated kinase 4
276
Interleukin-1 receptor-associated kinase 4
276
5.6
73
0.25
IRAK4IRAK4Q9NWZ3Q9NWZ3cytokine-mediatedsignalingpathwayinnateimmuneresponseinterleukin-1-mediatedsignalingpathwayintracellularsignaltransductionJNKcascadeMyD88-dependenttoll-likereceptorsignalingpathwayneutrophilmediatedimmunityneutrophilmigrationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofsmoothmusclecellproliferationproteinphosphorylationtoll-likereceptor9signalingpathwaytoll-likereceptorsignalingpathway
Defensin alpha 5
82
Defensin alpha 5
82
4.9
72
0.28
DEF5DEF5Q01523Q01523antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismpositiveregulationofinterleukin-8productionpositiveregulationofmembranepermeabilityproteinhomotetramerization
Thioredoxin
73
Thioredoxin
32
5.6
67
0.27
THIOTHIOP10599P10599activationofproteinkinaseBactivitycellredoxhomeostasisnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiation
Glutathione S-transferase P
102
Glutathione S-transferase P
102
5.9
40
0.42
GSTP1GSTP1P09211P09211cellularresponsetolipopolysaccharidecentralnervoussystemdevelopmentcommonmyeloidprogenitorcellproliferationglutathionederivativebiosyntheticprocessglutathionemetabolicprocesshepoxilinbiosyntheticprocesslinoleicacidmetabolicprocessnegativeregulationofacuteinflammatoryresponsenegativeregulationofapoptoticprocessnegativeregulationofbiosyntheticprocessnegativeregulationofERK1andERK2cascadenegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationoffibroblastproliferationnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofinterleukin-1betaproductionnegativeregulationofJUNkinaseactivitynegativeregulationofleukocyteproliferationnegativeregulationofMAPkinaseactivitynegativeregulationofMAPKcascadenegativeregulationofmonocytechemotacticprotein-1productionnegativeregulationofnitric-oxidesynthasebiosyntheticprocessnegativeregulationofproteinkinaseactivitynegativeregulationofstress-activatedMAPKcascadenegativeregulationoftumornecrosisfactorproductionnegativeregulationoftumornecrosisfactor-mediatedsignalingpathwaynitricoxidestoragepositiveregulationofsuperoxideaniongenerationprostaglandinmetabolicprocessregulationofERK1andERK2cascaderegulationofstress-activatedMAPKcascaderesponsetoreactiveoxygenspeciesxenobioticmetabolicprocess
Nitric oxide synthase, endothelial
94
Nitric oxide synthase, endothelial
94
4.0
59
0.43
NOS3NOS3P29474P29474angiogenesisaorticvalvemorphogenesisargininecatabolicprocessbloodvesseldiametermaintenancebloodvesselremodelingcalciumiontransportcellredoxhomeostasisendocardialcushionmorphogenesisendothelialcellmigrationestablishmentoflocalizationincellhomeostasisofnumberofcellswithinatissueinuteroembryonicdevelopmentlipopolysaccharide-mediatedsignalingpathwaylungdevelopmentmitochondrionorganizationnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodpressurenegativeregulationofcalciumiontransportnegativeregulationofcellpopulationproliferationnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrolaseactivitynegativeregulationofmusclehyperplasianegativeregulationofplateletactivationnegativeregulationofpotassiumiontransportnegativeregulationofsmoothmusclecellproliferationnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionovulationfromovarianfolliclepositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofgeneexpressionpositiveregulationofguanylatecyclaseactivitypositiveregulationofNotchsignalingpathwaypotassiumiontransportpulmonaryvalvemorphogenesisregulationofbloodpressureregulationofnervoussystemprocessregulationofsodiumiontransportregulationofsystemicarterialbloodpressurebyendothelinregulationoftheforceofheartcontractionbychemicalsignalremovalofsuperoxideradicalsresponsetofluidshearstressresponsetoheatresponsetohormoneresponsetolipopolysaccharidesmoothmusclehyperplasiavasodilationventricularseptummorphogenesis
Thymidylate synthase
174
Thymidylate synthase
174
4.0
89
0.28
TYSYTYSYP07607P07607agingcartilagedevelopmentcircadianrhythmdevelopmentalgrowthdTMPbiosyntheticprocessdTTPbiosyntheticprocessintestinalepithelialcellmaturationliverregenerationmethylationnegativeregulationoftranslationregulationoftranslationresponsetocytokineresponsetoethanolresponsetofolicacidresponsetoglucocorticoidresponsetoorganophosphorusresponsetoprogesteroneresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulustetrahydrofolateinterconversionuracilmetabolicprocess
C-C motif chemokine 3
33
C-C motif chemokine 3
57
5.9
70
0.24
CCL3CCL3P10147P10147astrocytecellmigrationcalciumiontransportcalcium-mediatedsignalingcellactivationcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytoskeletonorganizationeosinophilchemotaxiseosinophildegranulationexocytosisGprotein-coupledreceptorsignalingpathwaygranulocytechemotaxisinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofosteoclastdifferentiationneutrophilchemotaxisosteoblastdifferentiationpositiveregulationofcalciumionimportpositiveregulationofcalciumiontransportpositiveregulationofcalcium-mediatedsignalingpositiveregulationofcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofmicroglialcellactivationpositiveregulationofmicroglialcellmigrationpositiveregulationofnaturalkillercellchemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofproteinkinaseBsignalingpositiveregulationoftumornecrosisfactorproductionproteinkinaseBsignalingregulationofbehaviorregulationofcellshaperegulationofsensoryperceptionofpainreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolresponsetotoxicsubstancesignalingTcellchemotaxis
Galectin-1
131
Galectin-1
131
4.1
64
0.38
LEG1LEG1P11116P11116apoptoticprocesscell-celladhesionmyoblastdifferentiationplasmacelldifferentiationpositiveregulationofapoptoticprocesspositiveregulationofinflammatoryresponsepositiveregulationofviralentryintohostcellTcellcostimulation
Lectin-related NK cell receptor LY49L4
153
Lectin-related NK cell receptor LY49L4
148
5.6
79
0.23
Q9JIP9Q9JIP9Q9JIP9Q9JIP9
Caspase-2
320
Caspase-2
370
5.6
89
0.2
CASP2CASP2P42575P42575activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessagingapoptoticprocessapoptoticsignalingpathwaybraindevelopmentcellularresponsetoDNAdamagestimuluscellularresponsetomechanicalstimulusDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestectopicgermcellprogrammedcelldeathexecutionphaseofapoptosisextrinsicapoptoticsignalingpathwayinabsenceofligandintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageluteolysisnegativeregulationofapoptoticprocessnegativeregulationofnecroptoticprocessneuralretinadevelopmentpositiveregulationofapoptoticprocesspositiveregulationofapoptoticsignalingpathwaypositiveregulationofneuronapoptoticprocessproteinprocessingreleaseofcytochromecfrommitochondria
Thymidylate synthase
174
Thymidylate synthase
174
4.1
93
0.26
Q544L2Q544L2Q544L2Q544L2agingcartilagedevelopmentcircadianrhythmdevelopmentalgrowthdTMPbiosyntheticprocessdTTPbiosyntheticprocessintestinalepithelialcellmaturationliverregenerationmethylationresponsetocytokineresponsetoethanolresponsetofolicacidresponsetoglucocorticoidresponsetoorganophosphorusresponsetoprogesteroneresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulustetrahydrofolateinterconversionuracilmetabolicprocess
Toll-like receptor 13
527
Toll-like receptor 13
527
5.6
77
0.23
TLR13TLR13Q6R5N8Q6R5N8inflammatoryresponseinnateimmuneresponseMyD88-dependenttoll-likereceptorsignalingpathwayregulationofMAPKcascaderesponsetovirustoll-likereceptor13signalingpathwaytoll-likereceptorsignalingpathway
C-C motif chemokine 5
33
C-C motif chemokine 5
33
4.0
79
0.32
CCL5CCL5P13501P13501activationofphospholipaseDactivitycalciumiontransportcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetoviruschemokine-mediatedsignalingpathwaychemotaxisdendriticcellchemotaxiseosinophilchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwayinflammatoryresponseleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofinnateimmuneresponsepositiveregulationofmacrophagechemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftranslationalinitiationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofviralgenomereplicationproteinkinaseBsignalingregulationofchronicinflammatoryresponseregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetotoxicsubstanceresponsetovirus
Fibrinogen alpha chain
180
Fibrinogen beta chain
223
4.0
77
0.33
FIBAFIBBP02671P02675adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncelladhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulus
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
106
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
106
4.0
93
0.27
GPTGPTQ9H3H5Q9H3H5dolicholmetabolicprocessdolichol-linkedoligosaccharidebiosyntheticprocessproteinN-linkedglycosylationUDP-N-acetylglucosaminemetabolicprocess
Heat shock cognate 71 kDa protein
603
Heat shock cognate 71 kDa protein
574
4.9
63
0.32
HSP7CHSP7CP63018P63018agingATPmetabolicprocessaxo-dendritictransportcellularresponsetocadmiumioncellularresponsetoheatcellularresponsetounfoldedproteincerebellumdevelopmentchaperonecofactor-dependentproteinrefoldingchaperone-mediatedautophagychaperone-mediatedautophagytranslocationcomplexdisassemblychaperone-mediatedproteinfoldingclathrincoatdisassemblyestrouscycleforebraindevelopmentG1/StransitionofmitoticcellcyclekidneydevelopmentlateendosomalmicroautophagymaintenanceofpostsynapticspecializationstructuremodulationbyhostofviralprocessmRNAprocessingnegativeregulationofcardiacmusclecellapoptoticprocessnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofsupramolecularfiberorganizationnegativeregulationoftranscriptionDNA-templatedpositiveregulationbyhostofviralgenomereplicationpositiveregulationofcatalyticactivitypositiveregulationofgeneexpressionpositiveregulationoflysosomalmembranepermeabilitypositiveregulationofmRNAsplicingviaspliceosomepositiveregulationofphagocytosispositiveregulationofproteinrefoldingpositiveregulationofproteolysispositiveregulationofTcellmediatedcytotoxicityproteinautophosphorylationproteinfoldingproteinimportintonucleusproteinrefoldingproteintargetingtolysosomeinvolvedinchaperone-mediatedautophagyproteintransmembraneimportintointracellularorganelleprotein-containingcomplexdisassemblyregulationofcellcycleregulationofpostsynapseorganizationregulationofproteincomplexstabilityregulationofproteinstabilityresponsetoactivityresponsetoestradiolresponsetoethanolresponsetoheatresponsetonickelcationresponsetoodorantresponsetoprogesteroneresponsetostarvationresponsetoxenobioticstimulusRNAsplicingsensoryperceptionofsmellskeletalmuscletissuedevelopmentslowaxonaltransportsynapticvesicleuncoatingvesicle-mediatedtransport
Synaptic vesicle membrane protein VAT-1 homolog
324
Synaptic vesicle membrane protein VAT-1 homolog
324
6.0
112
0.15
VAT1VAT1Q99536Q99536negativeregulationofmitochondrialfusion
Golgi reassembly-stacking protein 2
103
Golgin-45
396
3.9
66
0.38
GORS2GO45Q99JX3Q8R2X8celldifferentiationestablishmentofproteinlocalizationtoplasmamembraneGolgiorganizationorganelleassemblyorganelleorganizationresponsetoendoplasmicreticulumstressspermatogenesisGolgitoplasmamembraneproteintransport
Complement C1s subcomponent
549
Complement C1s subcomponent
425
5.0
75
0.27
C1SC1SP09871P09871complementactivationclassicalpathwayinnateimmuneresponseproteolysis
F-box only protein 11
890
F-box only protein 11
868
4.0
62
0.41
FBX11FBX11Q86XK2Q86XK2proteinmodificationprocessproteinubiquitinationregulationofapoptoticprocesssensoryperceptionofsoundubiquitin-dependentproteincatabolicprocess
DNA repair protein RAD50
681
DNA repair protein RAD50
681
4.0
67
0.38
RAD50RAD50Q92878Q92878cellularresponsetoDNAdamagestimuluschromosomeorganizationinvolvedinmeioticcellcycleDNAdouble-strandbreakprocessingDNAduplexunwindingDNArecombinationDNArepairDNAstrandresectioninvolvedinreplicationforkprocessingdouble-strandbreakrepairhomologousrecombinationmitoticG2/Mtransitioncheckpointnegativeregulationoftelomerecappingnucleicacidphosphodiesterbondhydrolysispositiveregulationofkinaseactivitypositiveregulationofproteinautophosphorylationpositiveregulationoftelomeremaintenancereciprocalmeioticrecombinationregulationofmitoticrecombinationtelomeremaintenancetelomeremaintenanceviarecombinationtelomeremaintenanceviatelomerase"telomeric3overhangformation"
DNA polymerase lambda
543
DNA polymerase lambda
543
4.0
35
0.72
DPOLLDPOLLQ9UGP5Q9UGP5base-excisionrepairgap-fillingDNAbiosyntheticprocessDNAreplicationdouble-strandbreakrepairviahomologousrecombinationdouble-strandbreakrepairvianonhomologousendjoiningnucleotide-excisionrepairsomatichypermutationofimmunoglobulingenes
C-C motif chemokine 3
33
C-C motif chemokine 3
33
4.0
89
0.28
CCL3CCL3P10147P10147astrocytecellmigrationcalciumiontransportcalcium-mediatedsignalingcellactivationcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytoskeletonorganizationeosinophilchemotaxiseosinophildegranulationexocytosisGprotein-coupledreceptorsignalingpathwaygranulocytechemotaxisinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofosteoclastdifferentiationneutrophilchemotaxisosteoblastdifferentiationpositiveregulationofcalciumionimportpositiveregulationofcalciumiontransportpositiveregulationofcalcium-mediatedsignalingpositiveregulationofcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofmicroglialcellactivationpositiveregulationofmicroglialcellmigrationpositiveregulationofnaturalkillercellchemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofproteinkinaseBsignalingpositiveregulationoftumornecrosisfactorproductionproteinkinaseBsignalingregulationofbehaviorregulationofcellshaperegulationofsensoryperceptionofpainreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolresponsetotoxicsubstancesignalingTcellchemotaxis
Tumor necrosis factor ligand superfamily member 10
230
Tumor necrosis factor ligand superfamily member 10
230
4.0
81
0.31
TNF10TNF10P50591P50591apoptoticprocesscell-cellsignalingimmuneresponsemalegonaddevelopmentpositiveregulationofapoptoticprocesspositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofreleaseofcytochromecfrommitochondriaresponsetoinsulinsignaltransduction
Recombining binding protein suppressor of hairless
100
Mastermind-like protein 1
63
4.0
73
0.35
SUHMAML1Q06330Q92585angiogenesisaorticvalvedevelopmentarterialendothelialcellfatecommitmentatrioventricularcanaldevelopmentauditoryreceptorcellfatecommitmentBcelldifferentiationbloodvesselendothelialcellfatespecificationbloodvessellumenizationbloodvesselremodelingcardiacleftventriclemorphogenesiscardiacmusclecellmyoblastdifferentiationclubcelldifferentiationdefenseresponsetobacteriumdorsalaortamorphogenesisendocardiummorphogenesisepidermalcellfatespecificationepithelialcellproliferationepithelialtomesenchymaltransitionepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationhairfolliclematurationhumoralimmuneresponseinflammatoryresponsetoantigenicstimuluskeratinocytedifferentiationlabyrinthinelayerbloodvesseldevelopmentmyeloiddendriticcelldifferentiationnegativeregulationofcelldifferentiationnegativeregulationofcold-inducedthermogenesisnegativeregulationofossificationnegativeregulationofstemcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedNotchsignalinginvolvedinheartdevelopmentNotchsignalingpathwayoutflowtractmorphogenesispituitaryglanddevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofcanonicalWntsignalingpathwayinvolvedincardiacmusclecellfatecommitmentpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellproliferationinvolvedinheartmorphogenesispositiveregulationofephrinreceptorsignalingpathwaypositiveregulationofepithelialcellproliferationpositiveregulationofERBBsignalingpathwaypositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionofNotchreceptortargetpulmonaryvalvedevelopmentregulationofreproductiveprocessregulationoftimingofcelldifferentiationregulationoftranscriptionbyRNApolymeraseIIsebaceousglanddevelopmentsecondaryheartfieldspecificationsomaticstemcellpopulationmaintenancesomitogenesisstemcellproliferationventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesisatrioventricularnodecelldevelopmentatrioventricularnodedevelopmentmyoblastdifferentiationpositiveregulationofmyotubedifferentiationproteinphosphorylation
Protein MIS12 homolog
63
Polyamine-modulated factor 1
61
4.9
54
0.38
MIS12PMF1Q9H081Q6P1K2attachmentofmitoticspindlemicrotubulestokinetochorecelldivisionchromosomesegregationkinetochoreassemblymitoticsisterchromatidsegregationproteinlocalizationtokinetochorecellcycletranscriptionbyRNApolymeraseII
Nitric oxide synthase, inducible
110
Nitric oxide synthase, inducible
110
5.0
68
0.3
NOS2NOS2P35228P35228argininecatabolicprocesscellredoxhomeostasiscellularresponsetointerferon-gammacellularresponsetolipopolysaccharidecellularresponsetoxenobioticstimuluscircadianrhythmdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriuminflammatoryresponseinnateimmuneresponseinmucosanegativeregulationofbloodpressurenegativeregulationofgeneexpressionnegativeregulationofproteincatabolicprocessnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionpeptidyl-cysteineS-nitrosylationpositiveregulationofguanylatecyclaseactivitypositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofkillingofcellsofanotherorganismpositiveregulationofleukocytemediatedcytotoxicityprostaglandinsecretionregulationofcellpopulationproliferationregulationofcellularrespirationregulationofcytokineproductioninvolvedininflammatoryresponseregulationofinsulinsecretionresponsetobacteriumresponsetohormoneresponsetohypoxiaresponsetolipopolysaccharidesuperoxidemetabolicprocess
Cytoglobin
38
Cytoglobin
38
4.0
89
0.28
CYGBCYGBQ8WWM9Q8WWM9fattyacidoxidationnegativeregulationofcollagenbiosyntheticprocessnegativeregulationoffibroblastmigrationnegativeregulationofhepaticstellatecellactivationoxygentransportresponsetohypoxiaresponsetooxidativestress
Norrin
93
Norrin
93
3.9
77
0.33
NDPNDPQ00604Q00604decidualizationextracellularmatrix-cellsignalingnervoussystemdevelopmentNorrinsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoftranscriptionDNA-templatedretinavasculaturemorphogenesisincamera-typeeyevacuoleorganizationvisualperceptionWntsignalingpathway
Mucin-2
1088
Mucin-2
1088
3.9
85
0.3
MUC2MUC2Q02817Q02817maintenanceofgastrointestinalepithelium
Coagulation factor IX
291
Coagulation factor IX
133
3.9
88
0.29
FA9FA9P16293P16293bloodcoagulationproteolysiszymogenactivation
C-terminal-binding protein 2
140
C-terminal-binding protein 2
140
5.0
89
0.23
CTBP2CTBP2P56545P56545cellularresponsetoleukemiainhibitoryfactornegativeregulationofcellpopulationproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofchromatinbindingpositiveregulationofretinoicacidreceptorsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIsynapticvesicledockingviralgenomereplicationwhitefatcelldifferentiation
4-aminobutyrate aminotransferase, mitochondrial
166
4-aminobutyrate aminotransferase, mitochondrial
163
5.5
97
0.19
GABTGABTP80147P80147behavioralresponsetococainegamma-aminobutyricacidcatabolicprocessneurotransmittercatabolicprocess
Fibroblast growth factor receptor 2
491
Fibroblast growth factor receptor 2
491
5.0
38
0.53
FGFR2FGFR2P21802P21802angiogenesisanimalorganmorphogenesisapoptoticprocessaxonogenesisbonedevelopmentbonemineralizationbonemorphogenesisbranchelongationinvolvedinsalivaryglandmorphogenesisbranchinginvolvedinlabyrinthinelayermorphogenesisbranchinginvolvedinprostateglandmorphogenesisbranchinginvolvedinsalivaryglandmorphogenesisbranchingmorphogenesisofanervebudelongationinvolvedinlungbranchingcellfatecommitmentcell-cellsignalingcellularresponsetoretinoicacidcellularresponsetotransforminggrowthfactorbetastimulusdigestivetractdevelopmentembryoniccranialskeletonmorphogenesisembryonicdigestivetractmorphogenesisembryonicorgandevelopmentembryonicorganmorphogenesisembryonicpatternspecificationendochondralbonegrowthepidermismorphogenesisepithelialcelldifferentiationepithelialcellproliferationinvolvedinsalivaryglandmorphogenesisepithelialtomesenchymaltransitionfibroblastgrowthfactorreceptorsignalingpathwayfibroblastgrowthfactorreceptorsignalingpathwayinvolvedinhemopoiesisfibroblastgrowthfactorreceptorsignalingpathwayinvolvedinmammaryglandspecificationfibroblastgrowthfactorreceptorsignalingpathwayinvolvedinnegativeregulationofapoptoticprocessinbonemarrowcellfibroblastgrowthfactorreceptorsignalingpathwayinvolvedinorbitofrontalcortexdevelopmentfibroblastgrowthfactorreceptorsignalingpathwayinvolvedinpositiveregulationofcellproliferationinbonemarrowglandmorphogenesishairfolliclemorphogenesisinuteroembryonicdevelopmentinnerearmorphogenesislacrimalglanddevelopmentlateralsproutingfromanepitheliumlimbbudformationlungalveolusdevelopmentlungdevelopmentlunglobemorphogenesislung-associatedmesenchymedevelopmentmammaryglandbudformationmembranousseptummorphogenesismesenchymalcelldifferentiationmesenchymalcelldifferentiationinvolvedinlungdevelopmentmesenchymalcellproliferationinvolvedinlungdevelopmentmesodermalcelldifferentiationmidbraindevelopmentmorphogenesisofembryonicepitheliumnegativeregulationofkeratinocyteproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIodontogenesisorbitofrontalcortexdevelopmentorgangrowthoticvesicleformationoutflowtractseptummorphogenesispeptidyl-tyrosinephosphorylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellcyclepositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialcellproliferationinvolvedinlungmorphogenesispositiveregulationofERK1andERK2cascadepositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmesenchymalcellproliferationpositiveregulationofphospholipaseactivitypositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofWntsignalingpathwaypost-embryonicdevelopmentprostateepithelialcordarborizationinvolvedinprostateglandularacinusmorphogenesisprostateepithelialcordelongationprostateglandmorphogenesisproteinautophosphorylationpyramidalneurondevelopmentregulationofERK1andERK2cascaderegulationofmorphogenesisofabranchingstructureregulationofosteoblastdifferentiationregulationofosteoblastproliferationregulationofsmoothmusclecelldifferentiationregulationofsmoothenedsignalingpathwayreproductivestructuredevelopmentresponsetoethanolresponsetolipopolysaccharideskeletalsystemmorphogenesissquamousbasalepithelialstemcelldifferentiationinvolvedinprostateglandacinusdevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathwayuretericbuddevelopmentventricularcardiacmuscletissuemorphogenesisventricularzoneneuroblastdivisionwoundhealing
Glucocorticoid receptor
463
Glucocorticoid receptor
463
5.9
69
0.25
GCRGCRP04150P04150adrenalglanddevelopmentapoptoticprocesscellcyclecelldivisioncellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinorganizationchromosomesegregationglucocorticoidmetabolicprocessintracellularsteroidhormonereceptorsignalingpathwaymammaryglandductmorphogenesismaternalbehaviornegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedsignaltransduction
11-beta-hydroxysteroid dehydrogenase 1
272
11-beta-hydroxysteroid dehydrogenase 1
272
5.6
68
0.26
DHI1DHI1P28845P28845lungdevelopmentsteroidcatabolicprocess
C-C motif chemokine 14
35
C-C motif chemokine 14
59
5.9
65
0.26
CCL14CCL14Q16627Q16627cellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwayGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
Insulin-like growth factor I
96
Insulin-like growth factor-binding protein 1
206
5.6
77
0.23
IGF1IBP1P05019P08833activationofproteinkinaseBactivitybonemineralizationinvolvedinbonematurationcellactivationcellpopulationproliferationcellularresponsetoamyloid-betaERK1andERK2cascadeglycolatemetabolicprocessinsulin-likegrowthfactorreceptorsignalingpathwaymusclehypertrophymuscleorgandevelopmentmyoblastdifferentiationmyoblastproliferationmyotubecelldevelopmentnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofinterleukin-1betaproductionnegativeregulationofneuroinflammatoryresponsenegativeregulationofoocytedevelopmentnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftumornecrosisfactorproductionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcardiacmusclehypertrophypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRasproteinsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftrophectodermalcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseBsignalingproteinstabilizationproteoglycanbiosyntheticprocessRasproteinsignaltransductionregulationofgeneexpressionregulationofmulticellularorganismgrowthregulationofproteinphosphorylationresponsetoheatsignaltransductionskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationskeletalsystemdevelopmentwoundhealingaginginsulinreceptorsignalingpathwaynegativeregulationofcanonicalWntsignalingpathwaypositiveregulationofcellgrowthregulationofinsulin-likegrowthfactorreceptorsignalingpathwaytissueregeneration
E3 ubiquitin-protein ligase Mdm2
449
E3 ubiquitin-protein ligase Mdm2
449
5.6
101
0.18
MDM2MDM2Q00987Q00987amyloidfibrilformationapoptoticprocessatrialseptumdevelopmentatrioventricularvalvemorphogenesisbloodvesseldevelopmentbloodvesselremodelingcardiacseptummorphogenesiscellularresponsetoactinomycinDcellularresponsetogammaradiationcellularresponsetohypoxiaDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestendocardialcushionmorphogenesisestablishmentofproteinlocalizationnegativeregulationofDNAdamageresponsesignaltransductionbyp53classmediatornegativeregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatornegativeregulationofsignaltransductionbyp53classmediatornegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofcellpopulationproliferationpositiveregulationofmitoticcellcyclepositiveregulationofmusclecelldifferentiationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautoubiquitinationproteindestabilizationproteinlocalizationtonucleusproteinpolyubiquitinationproteinubiquitinationprotein-containingcomplexassemblyproteolysisinvolvedinproteincatabolicprocessregulationofcellcycleregulationofheartrateregulationofproteincatabolicprocessregulationoftranscriptionbyRNApolymeraseIIresponsetoantibiotictranscriptionfactorcatabolicprocesstraversingstartcontrolpointofmitoticcellcycleubiquitin-dependentproteincatabolicprocessventricularseptumdevelopment
Vesicle-associated membrane protein 7
21
Vesicle-associated membrane protein 7
21
5.8
65
0.26
VAMP7VAMP7P70280P70280calcium-ionregulatedexocytosisendoplasmicreticulumtoGolgivesicle-mediatedtransportendosometolysosometransporteosinophildegranulationexocytosisGolgitoplasmamembraneproteintransportnaturalkillercelldegranulationneutrophildegranulationphagocytosisengulfmentpositiveregulationofdendritemorphogenesispositiveregulationofhistaminesecretionbymastcellregulationofproteintargetingtovacuolarmembraneSNAREcomplexassemblytriglyceridetransportvesiclefusionvesiclefusionwithGolgiapparatusvesicletransportalongmicrotubulevesicle-mediatedtransport
Protein diaphanous homolog 1
428
Protein diaphanous homolog 1
428
4.1
78
0.31
DIAP1DIAP1O08808O08808actincytoskeletonorganizationactinfilamentpolymerizationbraindevelopmentcellularresponsetohistaminecytoskeletonorganizationneuronprojectiondevelopmentpositiveregulationofcellmigrationproteinlocalizationtomicrotubuleregulationofcellshaperegulationofcytoskeletonorganizationregulationofmicrotubule-basedprocessregulationofreleaseofsequesteredcalciumionintocytosolsensoryperceptionofsound
Gremlin-2
120
Gremlin-2
120
4.8
79
0.27
GREM2GREM2O88273O88273animalorganmorphogenesiscytokine-mediatedsignalingpathwaydeterminationofdorsalidentityembryonicbodymorphogenesisnegativeregulationofBMPsignalingpathwayregulationofcytokineactivitysequesteringofBMPfromreceptorviaBMPbinding
Thioredoxin reductase 1, cytoplasmic
608
Thioredoxin reductase 1, cytoplasmic
608
5.6
70
0.25
TRXR1TRXR1Q16881Q16881cellpopulationproliferationcellredoxhomeostasismesodermformationsignaltransduction
Nucleoside diphosphate kinase B
145
Nucleoside diphosphate kinase B
145
4.8
57
0.37
NDKBNDKBP22392P22392celladhesionCTPbiosyntheticprocessGTPbiosyntheticprocessintegrin-mediatedsignalingpathwaynegativeregulationofapoptoticprocessnucleosidediphosphatephosphorylationnucleosidetriphosphatebiosyntheticprocesspositiveregulationofepithelialcellproliferationpositiveregulationofkeratinocytedifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofapoptoticprocessregulationofepidermisdevelopmentUTPbiosyntheticprocess
Integrin alpha-X
712
Integrin alpha-X
712
4.8
70
0.3
ITAXITAXP20702P20702animalorganmorphogenesiscelladhesioncelladhesionmediatedbyintegrincell-celladhesioncell-matrixadhesiondefenseresponsetovirusheterotypiccell-celladhesionintegrin-mediatedsignalingpathwaypositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialtubemorphogenesispositiveregulationofgeneexpressionpositiveregulationofmyelination
Bifunctional glutamate/proline--tRNA ligase
105
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
205
4.0
57
0.44
SYEPAIMP2P07814Q13155cellularresponsetoinsulinstimuluscellularresponsetointerferon-gammaglutamyl-tRNAaminoacylationnegativeregulationoftranslationprolyl-tRNAaminoacylationprotein-containingcomplexassemblyregulationoflong-chainfattyacidimportintocelltRNAaminoacylationforproteintranslationapoptoticprocessnegativeregulationofcellpopulationproliferationpositiveregulationofaminoacyl-tRNAligaseactivitypositiveregulationofneurondeathpositiveregulationofproteinubiquitinationproteinubiquitinationtranslationtypeIIpneumocytedifferentiation
Proline-serine-threonine phosphatase-interacting protein 1
242
Proline-serine-threonine phosphatase-interacting protein 1
242
5.6
64
0.28
PPIP1PPIP1O43586O43586actinfilamentpolymerizationcelladhesionendocytosisinflammatoryresponseinnateimmuneresponsesignaltransduction
Poly(A)-specific ribonuclease PARN
108
Poly(A)-specific ribonuclease PARN
108
4.0
77
0.32
PARNPARNQ8VDG3Q8VDG3"boxH/ACARNA3-endprocessing"miRNAcatabolicprocessncRNAdeadenylationnuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecaynuclear-transcribedmRNApoly(A)tailshortening"polyadenylation-dependentsnoRNA3-endprocessing"positiveregulationoftelomeraseactivitypositiveregulationoftelomeremaintenanceviatelomeraseregulationoftelomeraseRNAlocalizationtoCajalbodyRNAphosphodiesterbondhydrolysisexonucleolytictelomeraseRNAstabilization
Glucocorticoid receptor
463
Glucocorticoid receptor
463
5.9
69
0.25
GCRGCRP79269P79269cellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluschromatinorganizationpositiveregulationoftranscriptionbyRNApolymeraseII
LINE-1 retrotransposable element ORF1 protein
104
LINE-1 retrotransposable element ORF1 protein
104
4.0
64
0.39
LORF1LORF1Q9UN81Q9UN81transpositionRNA-mediated
Vesicle-associated membrane protein 2
103
Syntaxin-1A
271
4.8
49
0.42
VAMP2STX1AP63045P32851calcium-ionregulatedexocytosiscellularresponsetoinsulinstimuluseosinophildegranulationexocyticinsertionofneurotransmitterreceptortopostsynapticmembraneGolgitoplasmamembraneproteintransporthormonesecretionlong-termsynapticpotentiationmembranefusionpositiveregulationofintracellularproteintransportproteintransportprotein-containingcomplexassemblyregulatedexocytosisregulationofdelayedrectifierpotassiumchannelactivityregulationofexocytosisregulationofsynapticvesiclerecyclingregulationofvesicle-mediatedtransportresponsetoglucoseSNAREcomplexassemblysynapticvesicledockingsynapticvesicleendocytosissynapticvesicleexocytosisvesiclefusionvesicle-mediatedtransportexocytosisinsulinsecretionintracellularproteintransportmodulationofexcitatorypostsynapticpotentialneurotransmittertransportpositiveregulationofcalciumion-dependentexocytosispositiveregulationofcatecholaminesecretionpositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofexocytosispositiveregulationofneurotransmittersecretionpositiveregulationofnorepinephrinesecretionproteinlocalizationtomembraneproteinsumoylationregulationofsynapticvesicleprimingresponsetogravitysecretionbycellsynapticvesiclefusiontopresynapticactivezonemembranevesicledocking
Neutrophil defensin 1
83
Neutrophil defensin 1
83
5.9
73
0.23
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismmodificationbyhostofsymbiontmembraneTcellchemotaxis
Liprin-alpha-2
113
Liprin-alpha-2
113
4.8
48
0.44
LIPA2LIPA2O75334O75334cell-matrixadhesiondensecoregranulecytoskeletaltransportregulationofdendriticspinedevelopmentregulationofdendriticspinemorphogenesissynapseorganization
Malonyl-CoA decarboxylase, mitochondrial
243
Malonyl-CoA decarboxylase, mitochondrial
243
4.8
62
0.33
1
✔DCMCDCMCO95822O95822acetyl-CoAbiosyntheticprocessacyl-CoAmetabolicprocessfattyacidbiosyntheticprocessfattyacidoxidationmalonyl-CoAcatabolicprocesspositiveregulationoffattyacidoxidationregulationoffattyacidbeta-oxidationregulationofglucosemetabolicprocessresponsetoischemia
Histone acetyltransferase p300
1408
Histone acetyltransferase p300
1408
4.0
53
0.47
EP300EP300Q09472Q09472animalorganmorphogenesisapoptoticprocessBcelldifferentiationbehavioraldefenseresponsecellcyclecellularresponsetoUVcircadianrhythmepigeneticmaintenanceofchromatinintranscription-competentconformationfacemorphogenesisfatcelldifferentiationheartdevelopmenthistoneacetylationhistoneH2BacetylationhistoneH3-K56acetylationhistoneH4acetylationinternalpeptidyl-lysineacetylationinternalproteinaminoacidacetylationintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorlearningormemorylungdevelopmentmacrophagederivedfoamcelldifferentiationmegakaryocytedevelopmentmulticellularorganismgrowthN-terminalpeptidyl-lysineacetylationnegativeregulationofgluconeogenesisnegativeregulationofprotein-containingcomplexassemblynegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentpeptidyl-lysineacetylationpeptidyl-lysinebutyrylationpeptidyl-lysinecrotonylationpeptidyl-lysinepropionylationplateletformationpositiveregulationbyhostofviraltranscriptionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofneuronprojectiondevelopmentpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofproteinbindingpositiveregulationofRNApolymeraseIIregulatoryregionsequence-specificDNAbindingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedinunfoldedproteinresponsepositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayproteinacetylationproteindestabilizationproteinstabilizationregulationofandrogenreceptorsignalingpathwayregulationofautophagyregulationofcellularresponsetoheatregulationofglycolyticprocessregulationofmitochondrionorganizationregulationofsignaltransductionbyp53classmediatorregulationoftubulindeacetylationresponsetoestrogenresponsetohypoxiaskeletalmuscletissuedevelopmentsomitogenesisstimulatoryC-typelectinreceptorsignalingpathwayswimmingthigmotaxistranscriptionbyRNApolymeraseII
Protein arginine N-methyltransferase 8
295
Protein arginine N-methyltransferase 8
295
4.0
80
0.31
ANM8ANM8Q9NR22Q9NR22histonemethylationpeptidyl-argininemethylationpeptidyl-argininemethylationtoasymmetrical-dimethylarginineproteinhomooligomerizationproteinmethylationregulationofproteinbinding
Pygopus homolog 1
371
Pygopus homolog 1
371
5.6
71
0.25
PYGO1PYGO1Q9Y3Y4Q9Y3Y4canonicalWntsignalingpathwayhematopoieticprogenitorcelldifferentiationkidneydevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationtonucleusspermatidnucleusdifferentiation
Dihydropyrimidine dehydrogenase [NADP(+)]
82
Dihydropyrimidine dehydrogenase [NADP(+)]
956
5.9
90
0.19
DPYDDPYDQ28943Q28943beta-alaninebiosyntheticprocessthymidinecatabolicprocessthyminecatabolicprocessuracilcatabolicprocess
Protein lin-9 homolog
122
Protein lin-37 homolog
119
4.1
86
0.29
LIN9LIN37Q5TKA1Q96GY3cellcycleDNAbiosyntheticprocessregulationofcellcycleregulationoftranscriptionbyRNApolymeraseIIreproductiontranscriptionDNA-templatednegativeregulationoftranscriptionbyRNApolymeraseII
LINE-1 retrotransposable element ORF1 protein
76
LINE-1 retrotransposable element ORF1 protein
76
4.1
68
0.36
LORF1LORF1Q9UN81Q9UN81transpositionRNA-mediated
Isoaspartyl peptidase/L-asparaginase
202
Isoaspartyl peptidase/L-asparaginase
202
4.8
113
0.19
ASGL1ASGL1Q7L266Q7L266asparaginecatabolicprocessviaL-aspartateproteolysis
Cysteine desulfurase, mitochondrial
381
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
95
4.8
86
0.24
NFS1ISCUQ9Y697Q9H1K12Fe-2Sclusterassemblyironincorporationintometallo-sulfurclusteriron-sulfurclusterassemblyMo-molybdopterincofactorbiosyntheticprocesscellularironionhomeostasisnegativeregulationofironionimportacrossplasmamembranepositiveregulationofaconitatehydrataseactivitypositiveregulationofmitochondrialelectrontransportNADHtoubiquinone
Killer cell lectin-like receptor 3
149
Killer cell lectin-like receptor 3
154
5.9
74
0.23
KLRA3KLRA3Q64329Q64329celladhesion
Nucleoside diphosphate kinase A
145
Nucleoside diphosphate kinase A
145
4.8
58
0.36
NDKANDKAP15531P15531celldifferentiationCTPbiosyntheticprocessendocytosisGTPbiosyntheticprocesslactationnegativeregulationofcellpopulationproliferationnervoussystemdevelopmentnucleosidediphosphatephosphorylationpositiveregulationofDNAbindingpositiveregulationofepithelialcellproliferationregulationofapoptoticprocessUTPbiosyntheticprocess
E3 ubiquitin-protein ligase MYLIP
400
E3 ubiquitin-protein ligase MYLIP
400
5.9
66
0.26
MYLIPMYLIPQ8WY64Q8WY64cholesterolhomeostasisnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationofneuronprojectiondevelopmentnervoussystemdevelopmentpositiveregulationofproteincatabolicprocessproteindestabilizationproteinubiquitinationregulationoflow-densitylipoproteinparticlereceptorcatabolicprocessubiquitin-dependentproteincatabolicprocess
Norrin
95
Norrin
95
4.8
84
0.25
NDPNDPQ00604Q00604decidualizationextracellularmatrix-cellsignalingnervoussystemdevelopmentNorrinsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoftranscriptionDNA-templatedretinavasculaturemorphogenesisincamera-typeeyevacuoleorganizationvisualperceptionWntsignalingpathway
Glucocorticoid receptor
482
Glucocorticoid receptor
482
5.9
68
0.25
GCRGCRP06536P06536adrenalglanddevelopmentagingandrogenmetabolicprocessbraindevelopmentcellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetomagnesiumioncellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinremodelingcircadianrhythmepigeneticmaintenanceofchromatinintranscription-competentconformationfemalepregnancyglucocorticoidmetabolicprocessglucocorticoidreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaylungdevelopmentmammaryglandductmorphogenesismaternalbehaviormuscleatrophynegativeregulationofapoptoticprocessnegativeregulationofsynapticplasticitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationofvascularpermeabilitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofdendriticspinedevelopmentpositiveregulationofglucocorticoidreceptorsignalingpathwaypositiveregulationofglutamatesecretionpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprotein-containingcomplexassemblyregulationofcellpopulationproliferationregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationofglucosemetabolicprocessregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetoactivityresponsetoarsenic-containingsubstanceresponsetocalciumionresponsetocorticosteroneresponsetodexamethasoneresponsetoelectricalstimulusresponsetoinactivityresponsetoinsulinresponsetomercuryionresponsetoradiation
Protein FosB
172
Transcription factor JunD
285
4.8
45
0.46
FOSBJUNDP53539P17535cellularresponsetocalciumioncellularresponsetohormonestimulusfemalepregnancynegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIresponsetocAMPresponsetocorticosteroneresponsetomechanicalstimulusresponsetomorphineresponsetoprogesteroneresponsetoxenobioticstimulustranscriptionbyRNApolymeraseIIagingcellularresponsetohypoxiacircadianrhythmosteoblastdevelopmentpositiveregulationofmacrophageactivationpositiveregulationofosteoblastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellcycleregulationofcellpopulationproliferationresponsetolightstimulusresponsetolipopolysaccharideresponsetoorganiccycliccompoundresponsetopeptidehormone
Nucleoside diphosphate kinase A 1
145
Nucleoside diphosphate kinase A 1
145
4.8
60
0.35
NDKA1NDKA1P52174P52174celldifferentiationCTPbiosyntheticprocessendocytosisGTPbiosyntheticprocessnervoussystemdevelopmentnucleosidediphosphatephosphorylationUTPbiosyntheticprocess
DNA polymerase alpha catalytic subunit
1281
DNA polymerase alpha subunit B
392
5.0
65
0.31
DPOLADPOA2P09884Q14181DNArepairDNAreplicationDNAreplicationinitiationDNAreplicationsynthesisofRNAprimerDNAstrandelongationinvolvedinDNAreplicationDNAsynthesisinvolvedinDNArepairdouble-strandbreakrepairvianonhomologousendjoininglaggingstrandelongationleadingstrandelongationmitoticDNAreplicationinitiationregulationoftypeIinterferonproductionproteinimportintonucleus
Thioredoxin reductase 1, cytoplasmic
458
Thioredoxin reductase 1, cytoplasmic
458
5.7
67
0.26
TRXR1TRXR1O89049O89049benzene-containingcompoundmetabolicprocesscellpopulationproliferationcellredoxhomeostasiscellularresponsetocopperioncellularresponsetohyperoxiagastrulationhalogenmetabolicprocesshydrogenperoxidecatabolicprocessmesodermformationNADPHoxidationplacentadevelopmentpositiveregulationofcelldeathresponsetoaxoninjuryresponsetohyperoxiaresponsetooxidativestressresponsetoseleniumionresponsetoxenobioticstimulusselenocysteinemetabolicprocess
Glutathione S-transferase P
99
Glutathione S-transferase P
99
4.5
44
0.5
GSTP1GSTP1P80031P80031glutathionederivativebiosyntheticprocessglutathionemetabolicprocesshepoxilinbiosyntheticprocessprostaglandinmetabolicprocess
Immunoglobulin heavy constant epsilon
209
Immunoglobulin heavy constant epsilon
209
4.2
76
0.31
IGHEIGHEP01854P01854adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Mitotic spindle assembly checkpoint protein MAD1
633
Mitotic spindle assembly checkpoint protein MAD1
633
4.2
88
0.27
MD1L1MD1L1Q9Y6D9Q9Y6D9attachmentofmitoticspindlemicrotubulestokinetochorecelldivisioncytoplasmicsequesteringofproteindeactivationofmitoticspindleassemblycheckpointmitoticspindleassemblycheckpointsignalingnegativeregulationofTcellproliferationpositiveregulationofmitoticcellcyclespindleassemblycheckpointregulationofmetaphaseplatecongressionthymusdevelopment
Norrin
95
Norrin
131
4.2
72
0.33
NDPNDPQ00604Q00604decidualizationextracellularmatrix-cellsignalingnervoussystemdevelopmentNorrinsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoftranscriptionDNA-templatedretinavasculaturemorphogenesisincamera-typeeyevacuoleorganizationvisualperceptionWntsignalingpathway
Nitric-oxide synthase (NADPH)
94
Nitric-oxide synthase (NADPH)
94
4.2
61
0.39
A0S0A6A0S0A6A0S0A6A0S0A6nitricoxidebiosyntheticprocess
Bile acid receptor
446
Bile acid receptor
446
4.5
75
0.29
NR1H4NR1H4Q96RI1Q96RI1bileacidmetabolicprocessbileacidsignalingpathwaycelldifferentiationcell-celljunctionassemblycellularglucosehomeostasiscellularresponsetobileacidcellularresponsetofattyacidcellularresponsetolipopolysaccharidecellularresponsetoorganonitrogencompoundcellulartriglyceridehomeostasischolesterolhomeostasisdefenseresponsetobacteriumfattyacidhomeostasishistoneH3-R17methylationinflammatoryresponseinnateimmuneresponseintracellularbileacidreceptorsignalingpathwayintracellularreceptorsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofinflammatoryresponsenegativeregulationofinterferon-gammaproductionnegativeregulationofinterleukin-1productionnegativeregulationofinterleukin-2productionnegativeregulationofinterleukin-6productionnegativeregulationofmonocytechemotacticprotein-1productionnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftumornecrosisfactorproductionnegativeregulationoftumornecrosisfactor-mediatedsignalingpathwaynegativeregulationofvery-low-densitylipoproteinparticleremodelingnitrogencataboliteactivationoftranscriptionfromRNApolymeraseIIpromoterNotchsignalingpathwaypositiveregulationofadiposetissuedevelopmentpositiveregulationofammoniaassimilationcyclepositiveregulationofglutamatemetabolicprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofinterleukin-17productionpositiveregulationofphosphatidicacidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofbileacidbiosyntheticprocessregulationofcholesterolmetabolicprocessregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulusregulationoflow-densitylipoproteinparticleclearanceregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedregulationofureametabolicprocesstoll-likereceptor4signalingpathwaytoll-likereceptor9signalingpathwaytranscriptionbyRNApolymeraseII
Galectin-1
131
Galectin-1
131
4.2
75
0.31
LEG1LEG1P11762P11762apoptoticprocesscell-celladhesioncellularresponsetoglucosestimuluscellularresponsetoorganiccycliccompoundmyoblastdifferentiationnegativeregulationofcell-substrateadhesionnegativeregulationofneuronprojectiondevelopmentplasmacelldifferentiationpositiveregulationofapoptoticprocesspositiveregulationoferythrocyteaggregationpositiveregulationofinflammatoryresponsepositiveregulationofviralentryintohostcellresponsetoaxoninjuryresponsetoisolationstressresponsetoxenobioticstimulusTcellcostimulation
Phospholipase A2, membrane associated
103
Phospholipase A2, membrane associated
103
5.8
75
0.23
PA2GAPA2GAP14555P14555arachidonicacidsecretioncytolysisdefenseresponsetoGram-positivebacteriuminflammatoryresponseintestinalstemcellhomeostasislipidcatabolicprocesslow-densitylipoproteinparticleremodelingphosphatidicacidmetabolicprocessphosphatidylcholinemetabolicprocessphosphatidylethanolaminemetabolicprocessphospholipidmetabolicprocesspositiveregulationofERK1andERK2cascadepositiveregulationofinflammatoryresponsepositiveregulationofmacrophagederivedfoamcelldifferentiationregulationofneutrophilactivation
Growth/differentiation factor 2
392
Growth/differentiation factor 2
392
4.5
86
0.26
GDF2GDF2Q9UK05Q9UK05activinreceptorsignalingpathwayangiogenesisbloodvesselmorphogenesisBMPsignalingpathwaybranchinginvolvedinbloodvesselmorphogenesiscartilagedevelopmentcellularironionhomeostasiscellularresponsetoBMPstimulusnegativeregulationofangiogenesisnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellgrowthnegativeregulationofDNAbiosyntheticprocessnegativeregulationofDNAreplicationnegativeregulationofendothelialcellmigrationnegativeregulationofendothelialcellproliferationossificationosteoblastdifferentiationpathway-restrictedSMADproteinphosphorylationpositiveregulationofangiogenesispositiveregulationofBMPsignalingpathwaypositiveregulationofcartilagedevelopmentpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofinterleukin-8productionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedSMADproteinsignaltransductiontranscriptionbyRNApolymeraseIIvasculogenesis
Probable ATP-dependent RNA helicase DDX20
98
Probable ATP-dependent RNA helicase DDX20
98
4.5
70
0.31
DDX20DDX20Q9UHI6Q9UHI6negativeregulationofcellpopulationproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIoogenesispositiveregulationofapoptoticprocessregulationofsteroidbiosyntheticprocessRNAprocessingspliceosomalsnRNPassemblyspliceosomaltri-snRNPcomplexassembly
Medulloblastoma antigen MU-MB-50.72
96
Medulloblastoma antigen MU-MB-50.72
96
4.2
67
0.35
Q7Z5E2Q7Z5E2Q7Z5E2Q7Z5E2
Talin rod domain-containing protein 1
220
Talin rod domain-containing protein 1
220
5.7
88
0.2
TLRN1TLRN1Q9H1K6Q9H1K6
Medulloblastoma antigen MU-MB-50.72
100
Medulloblastoma antigen MU-MB-50.72
100
4.5
52
0.42
Q7Z5E2Q7Z5E2Q7Z5E2Q7Z5E2
E3 ubiquitin-protein ligase Mdm2
449
E3 ubiquitin-protein ligase Mdm2
449
5.7
100
0.18
MDM2MDM2Q7YRZ8Q7YRZ8apoptoticprocessnegativeregulationofapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedproteinubiquitinationregulationofbiologicalqualityregulationofcellcycleregulationoftranscriptionbyRNApolymeraseII
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
201
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
201
4.6
79
0.28
CD38CD38P28907P28907apoptoticsignalingpathwayarterysmoothmusclecontractionBcellproliferationBcellreceptorsignalingpathwayfemalepregnancylong-termsynapticdepressionNADmetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofboneresorptionnegativeregulationofneuronprojectiondevelopmentnegativeregulationoftranscriptionDNA-templatedpositiveregulationofBcellproliferationpositiveregulationofcellgrowthpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofinsulinsecretionpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvasoconstrictionresponsetoestradiolresponsetohydroperoxideresponsetohypoxiaresponsetointerleukin-1responsetoprogesteroneresponsetoretinoicacidresponsetoxenobioticstimulussignaltransduction
Mothers against decapentaplegic homolog 7
278
Mothers against decapentaplegic homolog 7
278
4.6
88
0.25
SMAD7SMAD7O35253O35253adherensjunctionassemblyanatomicalstructuremorphogenesisarterymorphogenesisBMPsignalingpathwaycelldifferentiationcellularresponsetoleukemiainhibitoryfactorcellularresponsetotransforminggrowthfactorbetastimulusintracellularsignaltransductionnegativeregulationofBMPsignalingpathwaynegativeregulationofchondrocyteproliferationnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofossificationnegativeregulationofpathway-restrictedSMADproteinphosphorylationnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofpeptidyl-threoninephosphorylationnegativeregulationofproteinubiquitinationnegativeregulationofTcellcytokineproductionnegativeregulationofT-helper17celldifferentiationnegativeregulationofT-helper17typeimmuneresponsenegativeregulationoftranscriptionbycompetitivepromoterbindingnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofubiquitin-proteintransferaseactivitypathway-restrictedSMADproteinphosphorylationpositiveregulationofcell-celladhesionpositiveregulationofchondrocytehypertrophypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinubiquitinationproteinstabilizationprotein-containingcomplexlocalizationregulationofactivinreceptorsignalingpathwayregulationofcardiacmusclecontractionregulationofepithelialtomesenchymaltransitionregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationofventricularcardiacmusclecellmembranedepolarizationresponsetolaminarfluidshearstressSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentventricularcardiacmuscletissuemorphogenesisventricularseptummorphogenesis
DNA repair protein XRCC4
130
DNA repair protein XRCC4
130
4.6
67
0.33
XRCC4XRCC4Q13426Q13426DNAligationinvolvedinDNArepairdouble-strandbreakrepairdouble-strandbreakrepairvianonhomologousendjoiningimmunoglobulinV(D)Jrecombinationpositiveregulationofligaseactivitypositiveregulationofphosphatidylserineexposureonapoptoticcellsurfaceproteinlocalizationtositeofdouble-strandbreakresponsetoX-ray
3-ketoacyl-CoA thiolase, mitochondrial
128
3-ketoacyl-CoA thiolase, mitochondrial
128
4.2
79
0.3
THIMTHIMP42765P42765cellularresponsetohypoxiacholesterolbiosyntheticprocessfattyacidbeta-oxidationnegativeregulationofmitochondrialmembranepermeabilityinvolvedinapoptoticprocessnegativeregulationofmitochondrialoutermembranepermeabilizationinvolvedinapoptoticsignalingpathway
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
22
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
22
4.6
56
0.39
DECR2DECR2Q9NUI1Q9NUI1fattyacidbeta-oxidationusingacyl-CoAoxidasefattyacidmetabolicprocessunsaturatedfattyacidbiosyntheticprocess
Protein PML
91
Protein PML
72
5.7
66
0.27
PMLPMLP29590P29590activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocessbranchinginvolvedinmammaryglandductmorphogenesiscellfatecommitmentcellularresponsetointerleukin-4cellularresponsetoleukemiainhibitoryfactorcellularsenescencecircadianregulationofgeneexpressioncommon-partnerSMADproteinphosphorylationDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestendoplasmicreticulumcalciumionhomeostasisentrainmentofcircadianclockbyphotoperiodextrinsicapoptoticsignalingpathwayfibroblastmigrationinnateimmuneresponseintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressintrinsicapoptoticsignalingpathwayinresponsetooxidativestressmaintenanceofproteinlocationinnucleusmyeloidcelldifferentiationnegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofinterleukin-1betaproductionnegativeregulationofmitoticcellcyclenegativeregulationoftelomeraseactivitynegativeregulationoftelomeremaintenanceviatelomerasenegativeregulationoftranscriptionDNA-templatednegativeregulationoftranslationinresponsetooxidativestressnegativeregulationofubiquitin-dependentproteincatabolicprocessoncogene-inducedcellsenescencePMLbodyorganizationpositiveregulationofapoptoticprocessinvolvedinmammaryglandinvolutionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationoffibroblastproliferationpositiveregulationofhistonedeacetylationpositiveregulationofpeptidyl-lysineacetylationpositiveregulationofproteinlocalizationtochromosometelomericregionpositiveregulationofsignaltransductionbyp53classmediatorpositiveregulationoftelomeremaintenancepositiveregulationoftranscriptionDNA-templatedproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinimportintonucleusproteinstabilizationproteintargetingprotein-containingcomplexassemblyprotein-containingcomplexlocalizationregulationofcalciumiontransportintocytosolregulationofcelladhesionregulationofcellcycleregulationofcircadianrhythmregulationofdouble-strandbreakrepairregulationoftranscriptionDNA-templatedresponsetocytokineresponsetogammaradiationresponsetohypoxiaresponsetoUVretinoicacidreceptorsignalingpathwaysuppressionofviralreleasebyhosttransforminggrowthfactorbetareceptorsignalingpathway
Norrin
131
Norrin
93
5.7
70
0.25
NDPNDPQ00604Q00604decidualizationextracellularmatrix-cellsignalingnervoussystemdevelopmentNorrinsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoftranscriptionDNA-templatedretinavasculaturemorphogenesisincamera-typeeyevacuoleorganizationvisualperceptionWntsignalingpathway
Defensin-6
74
Defensin-6
74
4.6
76
0.29
DEF6DEF6Q01524Q01524antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosakillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Urokinase plasminogen activator surface receptor
93
Urokinase plasminogen activator surface receptor
46
4.6
70
0.31
UPARUPARQ03405Q03405bloodcoagulationchemotaxisnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaynegativeregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofDNAbindingpositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofhomotypiccell-celladhesionpositiveregulationofproteinphosphorylationpositiveregulationofreleaseofcytochromecfrommitochondriaregulationofcelladhesionregulationoffibrinolysisregulationofplasminogenactivationregulationofproteolysissignaltransductionurokinaseplasminogenactivatorsignalingpathway
C-C motif chemokine 1
33
C-C motif chemokine 1
57
5.7
60
0.29
CCL1CCL1P22362P22362antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiseosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-17productionpositiveregulationofmonocytechemotaxissignaltransductionviralprocess
Integrin alpha-X
712
Integrin alpha-X
655
5.7
72
0.24
ITAXITAXP20702P20702animalorganmorphogenesiscelladhesioncelladhesionmediatedbyintegrincell-celladhesioncell-matrixadhesiondefenseresponsetovirusheterotypiccell-celladhesionintegrin-mediatedsignalingpathwaypositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialtubemorphogenesispositiveregulationofgeneexpressionpositiveregulationofmyelination
Protein MIS12 homolog
63
Polyamine-modulated factor 1
64
4.5
54
0.41
MIS12PMF1Q9H081Q6P1K2attachmentofmitoticspindlemicrotubulestokinetochorecelldivisionchromosomesegregationkinetochoreassemblymitoticsisterchromatidsegregationproteinlocalizationtokinetochorecellcycletranscriptionbyRNApolymeraseII
Galectin-1
131
Galectin-1
131
4.2
63
0.38
LEG1LEG1P09382P09382apoptoticprocesscell-celladhesionmyoblastdifferentiationplasmacelldifferentiationpositiveregulationofapoptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinflammatoryresponsepositiveregulationofviralentryintohostcellregulationofapoptoticprocessTcellcostimulation
Ceramide-1-phosphate transfer protein
163
Ceramide-1-phosphate transfer protein
163
4.2
72
0.33
CPTPCPTPQ5TA50Q5TA50ceramide1-phosphatetransportceramidetransportglycosphingolipidmetabolicprocessintermembranelipidtransfernegativeregulationofautophagynegativeregulationofinterleukin-1betaproductionnegativeregulationofNLRP3inflammasomecomplexassembly
Lysozyme C
6
Lysozyme C
6
4.2
72
0.33
LYSCLYSCP11375P11375cytolysisdefenseresponsetobacteriummetabolicprocess
TNF receptor-associated factor 5
438
TNF receptor-associated factor 5
401
4.6
70
0.31
TRAF5TRAF5P70191P70191apoptoticprocessinterleukin-17-mediatedsignalingpathwaymRNAstabilizationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofJNKcascadepositiveregulationofNF-kappaBtranscriptionfactoractivityproteinK63-linkedubiquitinationregulationofapoptoticprocessregulationofI-kappaBkinase/NF-kappaBsignalingsignaltransductionsignaltransductioninvolvedinregulationofgeneexpressiontumornecrosisfactor-mediatedsignalingpathway
Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7
47
Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7
47
4.2
81
0.29
JMJD7JMJD7P0C872P0C872proteinhydroxylationproteolysis
Guanine nucleotide exchange factor for Rab-3A
97
Guanine nucleotide exchange factor for Rab-3A
97
4.2
52
0.46
R3GEFR3GEFQ8TBN0Q8TBN0exocytosisproteintransport
Histone H3.1
111
Histone H3.1
111
5.8
86
0.2
H31H31P68431P68431DNAreplication-dependentchromatinassemblynucleosomeassemblyregulationofgeneexpressionepigenetictelomereorganization
Mineralocorticoid receptor
645
Mineralocorticoid receptor
645
5.8
67
0.26
MCRMCRP08235P08235intracellularsteroidhormonereceptorsignalingpathwaypositiveregulationofNIK/NF-kappaBsignalingregulationoftranscriptionbyRNApolymeraseIIsignaltransduction
Cytochrome c
18
Cytochrome c
18
4.2
70
0.34
CYCCYCP99999P99999activationofcysteine-typeendopeptidaseactivityactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessbycytochromeccellularrespirationintrinsicapoptoticsignalingpathwaymitochondrialelectrontransportcytochromectooxygenmitochondrialelectrontransportubiquinoltocytochromecpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocess
Tyrosine aminotransferase
320
Tyrosine aminotransferase
320
4.2
104
0.23
ATTYATTYP17735P177352-oxoglutaratemetabolicprocessbiosyntheticprocessglutamatemetabolicprocessL-phenylalaninecatabolicprocessresponsetodexamethasoneresponsetomercuryionresponsetooxidativestresstyrosinecatabolicprocess
Early endosome antigen 1
1299
Early endosome antigen 1
1299
4.2
54
0.44
EEA1EEA1Q15075Q15075earlyendosometolateendosometransportendocytosismodulationbyhostofviralprocesssynapticvesicletoendosomefusionvesiclefusion
Lectin-related NK cell receptor LY49L4
148
Lectin-related NK cell receptor LY49L4
148
5.8
58
0.3
Q9JIP9Q9JIP9Q9JIP9Q9JIP9
Myosin-7
947
Myosin-7
947
4.6
52
0.42
MYH7MYH7P12883P12883adultheartdevelopmentATPmetabolicprocesscardiacmusclecontractioncardiacmusclehypertrophyinresponsetostressmusclecontractionmusclefilamentslidingregulationofheartrateregulationofslow-twitchskeletalmusclefibercontractionregulationoftheforceofheartcontractionregulationoftheforceofskeletalmusclecontractionsarcomereorganizationskeletalmusclecontractionstriatedmusclecontractiontransitionbetweenfastandslowfiberventricularcardiacmuscletissuemorphogenesis
Bile acid receptor
429
Bile acid receptor
429
4.6
71
0.31
NR1H4NR1H4Q62735Q62735bileacidandbilesalttransportbileacidmetabolicprocessbileacidsignalingpathwaycelldifferentiationcell-celljunctionassemblycellularglucosehomeostasiscellularresponsetobileacidcellularresponsetofattyacidcellularresponsetolipopolysaccharidecellularresponsetoorganonitrogencompoundcellularresponsetoxenobioticstimuluscellulartriglyceridehomeostasischolesterolhomeostasisdefenseresponsetobacteriumdigestivetractdevelopmentfattyacidhomeostasisglucosehomeostasishepatocyteproliferationhistoneH3-R17methylationinnateimmuneresponseintracellularbileacidreceptorsignalingpathwayintracellularreceptorsignalingpathwayleukocytemigrationinvolvedininflammatoryresponselipidlocalizationliverregenerationnegativeregulationofapoptoticprocessnegativeregulationofcollagenbiosyntheticprocessnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofinflammatoryresponsenegativeregulationofinterferon-gammaproductionnegativeregulationofinterleukin-1productionnegativeregulationofinterleukin-2productionnegativeregulationofinterleukin-6productionnegativeregulationofmonocytechemotacticprotein-1productionnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftriglyceridebiosyntheticprocessnegativeregulationoftumornecrosisfactorproductionnegativeregulationoftumornecrosisfactor-mediatedsignalingpathwaynegativeregulationofvery-low-densitylipoproteinparticleremodelingNotchsignalingpathwaypositiveregulationofadiposetissuedevelopmentpositiveregulationofammoniaassimilationcyclepositiveregulationofgeneexpressionpositiveregulationofglutamatemetabolicprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofinterleukin-17productionpositiveregulationofphosphatidicacidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofbileacidsecretionregulationofcarbohydratemetabolicprocessregulationofgeneexpressionregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulusregulationoflipidstorageregulationoflow-densitylipoproteinparticleclearanceregulationoftranscriptionbyRNApolymeraseIIregulationofureametabolicprocessresponseto17alpha-ethynylestradiolresponsetocholesterolresponsetoethanolresponsetofenofibrateresponsetoglucoseresponsetolipopolysaccharideresponsetonorepinephrineresponsetonutrientlevelsresponsetoorganiccycliccompoundresponsetoxenobioticstimulustoll-likereceptor4signalingpathwaytoll-likereceptor9signalingpathwaytriglyceridehomeostasis
Integrator complex subunit 9
637
Integrator complex subunit 11
513
4.2
77
0.31
INT9INT11Q9NV88Q5TA45regulationoftranscriptionelongationfromRNApolymeraseIIpromoter"snRNA3-endprocessing"snRNAprocessing
Gremlin-1
141
Gremlin-1
141
4.2
80
0.3
GREM1GREM1O60565O60565animalorganmorphogenesisapoptoticprocesscardiacmusclecelldifferentiationcardiacmusclecellmyoblastdifferentiationcellmigrationinvolvedinsproutingangiogenesiscellmorphogenesiscell-cellsignalingcollagenfibrilorganizationdeterminationofdorsalidentityembryoniclimbmorphogenesislimbdevelopmentmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesisnegativeregulationofapoptoticprocessnegativeregulationofBMPsignalingpathwaynegativeregulationofbonemineralizationnegativeregulationofbonemineralizationinvolvedinbonematurationnegativeregulationofboneremodelingnegativeregulationofbonetrabeculaformationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellgrowthnegativeregulationofchondrocytedifferentiationnegativeregulationofmonocytechemotaxisnegativeregulationofosteoblastdifferentiationnegativeregulationofosteoblastproliferationnegativeregulationofosteoclastproliferationnegativeregulationofpathway-restrictedSMADproteinphosphorylationnegativeregulationoftranscriptionDNA-templatedpositiveregulationofangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcellpopulationproliferationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofreceptorinternalizationpositiveregulationofsignalingreceptoractivitypositiveregulationoftelomeraseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIproximal/distalpatternformationregulationofepithelialtomesenchymaltransitionregulationoffocaladhesionassemblysequesteringofBMPfromreceptorviaBMPbindingsignaltransductionuretericbudformation
Synaptonemal complex protein 1
703
Synaptonemal complex protein 1
703
4.2
56
0.43
SYCP1SYCP1Q15431Q15431celldivisionchiasmaassemblyhomologouschromosomepairingatmeiosislateralelementassemblymeioticDNArepairsynthesisproteinhomotetramerizationreciprocalmeioticrecombinationregulationofproteinlocalizationspermDNAcondensationspermatogenesissynaptonemalcomplexassembly
LINE-1 retrotransposable element ORF1 protein
111
LINE-1 retrotransposable element ORF1 protein
111
4.2
64
0.37
LORF1LORF1Q9UN81Q9UN81transpositionRNA-mediated
C-C motif chemokine 14
35
C-C motif chemokine 14
35
4.2
78
0.31
CCL14CCL14Q16627Q16627cellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwayGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
Voltage-gated hydrogen channel 1
245
Voltage-gated hydrogen channel 1
245
4.6
53
0.41
HVCN1HVCN1Q3U2S8Q3U2S8cellularresponsetopHcellularresponsetozincionpositiveregulationofsuperoxideaniongenerationprotontransmembranetransportregulationofintracellularpHregulationofiontransmembranetransportresponsetopHresponsetozincion
Antizyme inhibitor 1
114
Antizyme inhibitor 1
358
4.6
72
0.3
AZIN1AZIN1O35484O35484negativeregulationofproteincatabolicprocesspolyaminemetabolicprocesspositiveregulationofcentrosomeduplicationpositiveregulationofepithelialcellproliferationpositiveregulationofpolyaminetransmembranetransportputrescinebiosyntheticprocessfromornithine
Nucleoprotein TPR
75
Nucleoprotein TPR
75
4.6
54
0.4
TPRTPRP12270P12270celldivisioncellularresponsetoheatcellularresponsetointerferon-alphamitoticspindleassemblycheckpointsignalingmRNAexportfromnucleusmRNAexportfromnucleusinresponsetoheatstressnegativeregulationofRNAexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranslationalinitiationnuclearporeorganizationnucleocytoplasmictransportpositiveregulationofheterochromatinassemblypositiveregulationofintracellularproteintransportpositiveregulationofmitoticcellcyclespindleassemblycheckpointpositiveregulationofproteinexportfromnucleuspositiveregulationofproteinimportintonucleusproteinimportintonucleusregulationofmitoticsisterchromatidseparationregulationofmitoticspindleassemblyregulationofproteinlocalizationresponsetoepidermalgrowthfactorRNAexportfromnucleusRNAimportintonucleus
Xanthine dehydrogenase/oxidase
487
Xanthine dehydrogenase/oxidase
1317
4.0
74
0.34
XDHXDHP80457P80457xanthinecatabolicprocess
ATP-dependent RNA helicase DHX8
651
ATP-dependent RNA helicase DHX8
651
4.9
78
0.26
DHX8DHX8Q14562Q14562mRNAsplicingviaspliceosomeRNAprocessingRNAsplicingspliceosomalcomplexdisassembly
Hemoglobin subunit beta
113
Hemoglobin subunit beta
113
4.9
87
0.24
HBBHBBP68871P68871carbondioxidetransportcellularoxidantdetoxificationhydrogenperoxidecatabolicprocessnitricoxidetransportoxygentransportplateletaggregationpositiveregulationofcelldeathpositiveregulationofnitricoxidebiosyntheticprocessregulationofbloodpressurerenalabsorptionresponsetohydrogenperoxide
Copper transport protein ATOX1
12
Copper-transporting ATPase 1
22
4.9
65
0.32
ATOX1ATP7AO00244Q04656cellularcopperionhomeostasiscopperiontransportresponsetooxidativestressbloodvesseldevelopmentbloodvesselremodelingcartilagedevelopmentcatecholaminemetabolicprocesscellularresponsetoaminoacidstimuluscellularresponsetoantibioticcellularresponsetocadmiumioncellularresponsetocobaltioncellularresponsetocopperioncellularresponsetohypoxiacellularresponsetoironioncellularresponsetoleadioncellularresponsetoplatelet-derivedgrowthfactorstimuluscentralnervoussystemneurondevelopmentcerebellarPurkinjecelldifferentiationcollagenfibrilorganizationcopperionexportcopperionhomeostasiscopperionimportdetoxificationofcopperiondopaminemetabolicprocesselasticfiberassemblyelastinbiosyntheticprocessepinephrinemetabolicprocessextracellularmatrixorganizationfemalepregnancyhairfolliclemorphogenesisinuteroembryonicdevelopmentlactationliverdevelopmentlocomotorybehaviorlungalveolusdevelopmentmitochondrionorganizationnegativeregulationofironiontransmembranetransportneuronprojectionmorphogenesisnorepinephrinemetabolicprocesspeptidyl-lysinemodificationpigmentationpositiveregulationofcatalyticactivitypositiveregulationofcellsizepositiveregulationofepithelialcellproliferationpositiveregulationoflamellipodiumassemblypositiveregulationofmelaninbiosyntheticprocesspositiveregulationofresponsetowoundingpositiveregulationoftyrosinaseactivitypositiveregulationofvascularassociatedsmoothmusclecellmigrationpyramidalneurondevelopmentregulationofcytochrome-coxidaseactivityregulationofgeneexpressionregulationofoxidativephosphorylationremovalofsuperoxideradicalsresponsetoiron(III)ionresponsetomanganeseionresponsetozincionserotoninmetabolicprocessskindevelopmentT-helpercelldifferentiationtryptophanmetabolicprocess
E3 ubiquitin-protein ligase RNF31
893
E3 ubiquitin-protein ligase RNF31
885
4.9
64
0.32
RNF31RNF31Q96EP0Q96EP0CD40signalingpathwaydefenseresponsetobacteriumnegativeregulationofnecroptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteintargetingtomitochondrionpositiveregulationofxenophagyproteinlinearpolyubiquitinationproteinpolyubiquitinationTcellreceptorsignalingpathway
Syntenin-1
120
Syntenin-1
120
4.9
70
0.29
SDCB1SDCB1Q9JI92Q9JI92actincytoskeletonorganizationchemicalsynaptictransmissionnegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofreceptorinternalizationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofexosomalsecretionpositiveregulationofextracellularexosomeassemblypositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofphosphorylationpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypresynapseassemblyRasproteinsignaltransductionregulationofmitoticcellcycle
S-phase kinase-associated protein 1
120
S-phase kinase-associated protein 2
111
5.6
72
0.25
SKP1SKP2P63208Q13309histoneH2AmonoubiquitinationmaintenanceofproteinlocationinnucleuspositiveregulationofubiquitinproteinligaseactivityproteinK48-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocessdefenseresponsetovirusG1/StransitionofmitoticcellcycleG2/Mtransitionofmitoticcellcycleinnateimmuneresponsepositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofproteinpolyubiquitinationproteasome-mediatedubiquitin-dependentproteincatabolicprocessregulationofapoptoticprocessregulationofcellcycle
Brain-specific angiogenesis inhibitor 1-associated protein 2
195
Brain-specific angiogenesis inhibitor 1-associated protein 2
230
5.9
69
0.25
BAIP2BAIP2Q9UQB8Q9UQB8actincrosslinkformationactinfilamentbundleassemblyaxonogenesisbraindevelopmentcellularresponsetoepidermalgrowthfactorstimuluscellularresponsetoL-glutamatedendritedevelopmentinsulinreceptorsignalingpathwaymodificationofsynapticstructuremodulatingsynaptictransmissionplasmamembraneorganizationpositiveregulationofactincytoskeletonreorganizationpositiveregulationofactinfilamentpolymerizationpositiveregulationofdendriticspinemorphogenesispositiveregulationofexcitatorypostsynapticpotentialproteinlocalizationtosynapseregulationofactincytoskeletonorganizationregulationofcellshaperegulationofmodificationofpostsynapticactincytoskeletonregulationofsynapticplasticityresponsetobacterium
Laforin
250
Laforin
250
4.9
79
0.26
EPM2AEPM2AO95278O95278autophagosomeassemblycalciumiontransportcarbohydratephosphorylationdephosphorylationglialcellproliferationglycogenbiosyntheticprocessglycogenmetabolicprocesshabituationL-glutamatetransmembranetransportmitochondrionorganizationnegativeregulationofcellcyclenegativeregulationofdephosphorylationnegativeregulationofgeneexpressionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofphosphataseactivitypeptidyl-tyrosinedephosphorylationphosphorylatedcarbohydratedephosphorylationpositiveregulationofmacroautophagyproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindephosphorylationregulationofcellgrowthregulationofglycogen(starch)synthaseactivityregulationofproteasomalproteincatabolicprocessregulationofproteinimportintonucleusregulationofproteinkinaseactivityregulationofproteinlocalizationtoplasmamembraneregulationofproteinubiquitinationregulationofubiquitinproteinligaseactivityWntsignalingpathway
MHC class I recognition receptor Ly49I
154
MHC class I recognition receptor Ly49I
149
5.6
75
0.24
Q9JHN9Q9JHN9Q9JHN9Q9JHN9
Caspase-1
136
Caspase-1
362
5.9
62
0.27
CASP1CASP1P29466P29466apoptoticprocesscellularresponsetointerferon-gammacellularresponsetolipopolysaccharidecellularresponsetomechanicalstimuluscellularresponsetoorganicsubstancecytokineprecursorprocessingdefenseresponsetovirusicosanoidbiosyntheticprocessosmosensorysignalingpathwaypatternrecognitionreceptorsignalingpathwaypositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayproteinautoprocessingproteolysispyroptosisregulationofapoptoticprocessregulationofinflammatoryresponsesignaltransductionsignalingreceptorligandprecursorprocessing
Defensin-6
88
Defensin-6
88
5.6
73
0.25
DEF6DEF6Q01524Q01524antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosakillingofcellsofanotherorganismmembranedisruptioninanotherorganism
GA-binding protein alpha chain
421
GA-binding protein subunit beta-1
137
4.0
51
0.49
GABPAGABP1Q00422Q00420blastocystformationcelldifferentiationcellularresponsetodopamineinuteroembryonicdevelopmentnegativeregulationofmegakaryocytedifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIImitochondrionorganization
NKG2-D type II integral membrane protein
96
NKG2-D type II integral membrane protein
105
5.9
80
0.21
NKG2DNKG2DP26718P26718adaptiveimmuneresponsecelldifferentiationcellularresponsetolipopolysaccharidedefenseresponsetoGram-positivebacteriumnaturalkillercellactivationnaturalkillercellmediatedcytotoxicitynegativeregulationofGTPaseactivitynegativeregulationofnaturalkillercellchemotaxisnitricoxidebiosyntheticprocesspositiveregulationofinterferon-gammaproductionpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnitricoxidebiosyntheticprocesssignaltransductionstimulatoryC-typelectinreceptorsignalingpathwayTcellcostimulation
RecQ-like DNA helicase BLM
380
RecQ-like DNA helicase BLM
380
4.9
75
0.27
BLMBLMP54132P54132cellularresponsetocamptothecincellularresponsetoDNAdamagestimuluscellularresponsetohydroxyureacellularresponsetoionizingradiationDNAdouble-strandbreakprocessingDNAduplexunwindingDNArecombinationDNArepairDNAreplicationDNAunwindinginvolvedinDNAreplicationdouble-strandbreakrepairviahomologousrecombinationG-quadruplexDNAunwindingmitoticG2DNAdamagecheckpointsignalingnegativeregulationofcelldivisionnegativeregulationofDNArecombinationpositiveregulationoftranscriptionDNA-templatedproteincomplexoligomerizationproteinhomooligomerizationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofDNA-templatedDNAreplicationreplicationforkprocessingreplicationforkprotectionresolutionofrecombinationintermediatesresponsetoX-rayt-circleformationtelomeremaintenancetelomeremaintenanceviasemi-conservativereplicationtelomericD-loopdisassembly
Protein ENL
99
Protein ENL
99
5.6
68
0.26
ENLENLQ03111Q03111chromatinremodelinghistoneacetylationnegativeregulationofproteinkinaseactivityregulationoftranscriptionbyRNApolymeraseII
Killer cell lectin-like receptor 3
154
Killer cell lectin-like receptor 3
154
5.9
80
0.21
KLRA3KLRA3Q61198Q61198celladhesion
Kallikrein-7
137
Kallikrein-7
137
5.6
66
0.27
KLK7KLK7P49862P49862epidermisdevelopmentextracellularmatrixdisassemblypositiveregulationofantibacterialpeptideproductionproteolysis
Ubiquitin carboxyl-terminal hydrolase MINDY-2
429
Ubiquitin carboxyl-terminal hydrolase MINDY-2
429
3.7
87
0.31
MINY2MINY2Q8NBR6Q8NBR6proteinK48-linkeddeubiquitination
Spermine synthase
347
Spermine synthase
347
3.7
75
0.36
SPSYSPSYP52788P52788methioninemetabolicprocesspolyaminemetabolicprocesssperminebiosyntheticprocess
F-box only protein 11
865
F-box only protein 11
888
4.0
64
0.39
FBX11FBX11Q86XK2Q86XK2proteinmodificationprocessproteinubiquitinationregulationofapoptoticprocesssensoryperceptionofsoundubiquitin-dependentproteincatabolicprocess
Myosin-7
905
Myosin-7
905
3.3
53
0.58
MYH7MYH7P12883P12883adultheartdevelopmentATPmetabolicprocesscardiacmusclecontractioncardiacmusclehypertrophyinresponsetostressmusclecontractionmusclefilamentslidingregulationofheartrateregulationofslow-twitchskeletalmusclefibercontractionregulationoftheforceofheartcontractionregulationoftheforceofskeletalmusclecontractionsarcomereorganizationskeletalmusclecontractionstriatedmusclecontractiontransitionbetweenfastandslowfiberventricularcardiacmuscletissuemorphogenesis
D-3-phosphoglycerate dehydrogenase
116
D-3-phosphoglycerate dehydrogenase
116
3.3
99
0.31
SERASERAO43175O43175braindevelopmentG1toG0transitiongamma-aminobutyricacidmetabolicprocessglialcelldevelopmentglutaminemetabolicprocessglycinemetabolicprocessL-serinebiosyntheticprocessneuraltubedevelopmentneuronprojectiondevelopmentregulationofgeneexpressionspinalcorddevelopmenttaurinemetabolicprocessthreoninemetabolicprocess
cGMP-specific 3',5'-cyclic phosphodiesterase
677
cGMP-specific 3',5'-cyclic phosphodiesterase
677
3.3
48
0.64
PDE5APDE5AO76074O76074cGMPcatabolicprocessnegativeregulationofcardiacmusclecontractionnegativeregulationofTcellproliferationoocytedevelopmentpositiveregulationofcardiacmusclehypertrophypositiveregulationofMAPkinaseactivitypositiveregulationofoocytedevelopmentregulationofnitricoxidemediatedsignaltransductionrelaxationofcardiacmusclesignaltransductionTcellproliferation
Mitogen-activated protein kinase kinase kinase 8
222
Mitogen-activated protein kinase kinase kinase 8
222
3.3
66
0.46
M3K8M3K8P41279P41279cellcycleMAPKcascadeproteinphosphorylationTcellcostimulation
Cytidine deaminase
59
Cytidine deaminase
65
3.3
92
0.33
CDDCDDP56389P56389cellularresponsetoexternalbioticstimulusCMPcatabolicprocesscytidinedeaminationdCMPcatabolicprocessnegativeregulationofcellgrowthnegativeregulationofnucleotidemetabolicprocessresponsetocycloheximideUMPsalvage
Parkinson disease protein 7
53
Parkinson disease protein 7
53
3.3
75
0.4
1
✔PARK7PARK7Q99497Q99497activationofproteinkinaseBactivityadultlocomotorybehaviorautophagycellulardetoxificationofaldehydecellulardetoxificationofmethylglyoxalcellularresponsetoglyoxalcellularresponsetohydrogenperoxidecellularresponsetooxidativestressdetectionofoxidativestressdetoxificationofcopperiondetoxificationofmercuryionDNArepairdopamineuptakeinvolvedinsynaptictransmissionglucosehomeostasisglutathionedeglycationglycolatebiosyntheticprocessglyoxalmetabolicprocessguaninedeglycationguaninedeglycationglyoxalremovalguaninedeglycationmethylglyoxalremovalhistonemodificationhydrogenperoxidemetabolicprocessinflammatoryresponseinsulinsecretionlactatebiosyntheticprocessmembranedepolarizationmembranehyperpolarizationmethylglyoxalcatabolicprocesstolactatemethylglyoxalmetabolicprocessmitochondrionorganizationnegativeregulationofapoptoticprocessnegativeregulationofcelldeathnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaynegativeregulationofdeath-inducingsignalingcomplexassemblynegativeregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofhydrogenperoxide-inducedneurondeathnegativeregulationofhydrogenperoxide-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofneuronapoptoticprocessnegativeregulationofneurondeathnegativeregulationofnitrosativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofoxidativestress-inducedcelldeathnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofproteinacetylationnegativeregulationofproteinbindingnegativeregulationofproteinexportfromnucleusnegativeregulationofproteinK48-linkeddeubiquitinationnegativeregulationofproteinkinaseactivitynegativeregulationofproteinphosphorylationnegativeregulationofproteinsumoylationnegativeregulationofproteinubiquitinationnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofTRAIL-activatedapoptoticsignalingpathwaynegativeregulationofubiquitin-proteintransferaseactivitynegativeregulationofubiquitin-specificproteaseactivitypeptidyl-argininedeglycationpeptidyl-cysteinedeglycationpeptidyl-lysinedeglycationpositiveregulationofacuteinflammatoryresponsetoantigenicstimuluspositiveregulationofandrogenreceptoractivitypositiveregulationofautophagyofmitochondrionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofdopaminebiosyntheticprocesspositiveregulationofgeneexpressionpositiveregulationofinterleukin-8productionpositiveregulationofL-dopabiosyntheticprocesspositiveregulationofL-dopadecarboxylaseactivitypositiveregulationofmitochondrialelectrontransportNADHtoubiquinonepositiveregulationofNAD(P)Hoxidaseactivitypositiveregulationofoxidativephosphorylationuncoupleractivitypositiveregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofprotein-containingcomplexassemblypositiveregulationofpyrroline-5-carboxylatereductaseactivitypositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofsuperoxidedismutaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftyrosine3-monooxygenaseactivityproteindeglycationglyoxalremovalproteindeglycationmethylglyoxalremovalproteindeglycosylationproteinstabilizationproteolysisRasproteinsignaltransductionregulationofandrogenreceptorsignalingpathwayregulationofhistoneacetylationregulationofhistoneubiquitinationregulationofinflammatoryresponseregulationofmitochondrialmembranepotentialregulationofneuronapoptoticprocessregulationofsupramolecularfiberorganizationresponsetooxidativestresssinglefertilization
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
166
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
166
3.3
98
0.31
MTDCMTDCP13995P13995folicacidmetabolicprocesstetrahydrofolateinterconversiontetrahydrofolatemetabolicprocess
Interleukin-23 subunit alpha
73
Interleukin-12 subunit beta
199
3.0
50
0.66
IL23AIL12BQ9NPF7P29460defenseresponsetoGram-negativebacteriumdefenseresponsetovirusimmuneresponseinflammatoryresponseinnateimmuneresponsenegativeregulationofinterleukin-10productionpositiveregulationofactivatedTcellproliferationpositiveregulationofactivationofJanuskinaseactivitypositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-17productionpositiveregulationofmemoryTcelldifferentiationpositiveregulationofnaturalkillercellactivationpositiveregulationofnaturalkillercellproliferationpositiveregulationofneutrophilchemotaxispositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofNKTcellactivationpositiveregulationofNKTcellproliferationpositiveregulationofosteoclastdifferentiationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofTcellmediatedcytotoxicitypositiveregulationofTcellproliferationpositiveregulationofT-helper1typeimmuneresponsepositiveregulationofT-helper17celllineagecommitmentpositiveregulationofT-helper17typeimmuneresponsepositiveregulationoftissueremodelingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftyrosinephosphorylationofSTATproteinregulationoftyrosinephosphorylationofSTATproteinTcellproliferationtissueremodelingcellmigrationcellularresponsetointerferon-gammacellularresponsetolipopolysaccharidecytokine-mediatedsignalingpathwaydefenseresponsetoprotozoannaturalkillercellactivationnaturalkillercellactivationinvolvedinimmuneresponsenegativeregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisnegativeregulationofinflammatoryresponsetoantigenicstimulusnegativeregulationofinterleukin-17productionnegativeregulationofproteinsecretionnegativeregulationofsmoothmusclecellproliferationnegativeregulationofvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofcelladhesionpositiveregulationoflymphocyteproliferationpositiveregulationofmononuclearcellproliferationpositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationofsmoothmusclecellapoptoticprocessregulationofcytokineproductionresponsetoUV-BsensoryperceptionofpainsexualreproductionT-helper1typeimmuneresponseT-helpercelldifferentiation
Immunoglobulin kappa constant
107
Ig gamma-2A chain C region, membrane-bound form
14
3.0
nan
nan
IGKCGCAMP01837P01865adaptiveimmuneresponseBcelldifferentiationBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationantibody-dependentcellularcytotoxicityantigenprocessingandpresentationearlyendosometolateendosometransportendosometolysosometransporthumoralimmuneresponsemediatedbycirculatingimmunoglobulinimmunoglobulinmediatedimmuneresponsepositiveregulationofendocytosispositiveregulationofimmuneresponsepositiveregulationofphagocytosispositiveregulationoftypeIhypersensitivitypositiveregulationoftypeIIahypersensitivityregulationofproteolysis
Filamin-C
712
Filamin-C
712
3.0
60
0.55
FLNCFLNCQ14315Q14315sarcomereorganization
T-cell receptor, sp3.4 alpha chain
161
Human nkt tcr beta chain
176
3.3
74
0.41
K7N5N2K7N5M4K7N5N2K7N5M4
Transforming growth factor beta-2 proprotein
379
Transforming growth factor beta-2 proprotein
379
3.1
95
0.34
TGFB2TGFB2P61812P61812activationofproteinkinaseactivityascendingaortamorphogenesisatrialseptummorphogenesisatrialseptumprimummorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwaycardiacepithelialtomesenchymaltransitioncardiacmusclecellproliferationcardiacrightventriclemorphogenesiscardioblastdifferentiationcelldeathcellmigrationcellmorphogenesiscell-celljunctionorganizationcollagenfibrilorganizationcranialskeletalsystemdevelopmentdopaminebiosyntheticprocessembryodevelopmentendinginbirthoregghatchingembryonicdigestivetractdevelopmentembryoniclimbmorphogenesisendocardialcushionfusionendocardialcushionmorphogenesisepithelialtomesenchymaltransitionextrinsicapoptoticsignalingpathwayeyedevelopmentgenerationofneuronsglialcellmigrationhairfollicledevelopmenthairfolliclemorphogenesisheartdevelopmentheartmorphogenesisheartvalvemorphogenesishemopoiesisinnereardevelopmentkidneydevelopmentmalegonaddevelopmentmembranousseptummorphogenesisnegativeregulationofalkalinephosphataseactivitynegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofepithelialcellproliferationnegativeregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationnegativeregulationofgeneexpressionnegativeregulationofmacrophagecytokineproductionnegativeregulationofRasproteinsignaltransductionneuralretinadevelopmentneuraltubeclosureneurondevelopmentneutrophilchemotaxisodontogenesisoutflowtractseptummorphogenesispathway-restrictedSMADproteinphosphorylationpharyngealarcharterymorphogenesispositiveregulationofcardioblastdifferentiationpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcellcyclepositiveregulationofcelldivisionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationpositiveregulationofheartcontractionpositiveregulationofimmuneresponsepositiveregulationofintegrinbiosyntheticprocesspositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationofNotchsignalingpathwaypositiveregulationofossificationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofstress-activatedMAPKcascadepositiveregulationoftimingofcatagenproteinphosphorylationpulmonaryvalvemorphogenesisregulationofapoptoticprocessinvolvedinoutflowtractmorphogenesisregulationofcellpopulationproliferationregulationoftimingofcatagenregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetoprogesteroneresponsetowoundingresponsetoxenobioticstimulussalivaryglandmorphogenesissecondarypalatedevelopmentskeletalsystemdevelopmentSMADproteinsignaltransductionsomaticstemcelldivisionsubstantiapropriaofcorneadevelopmenttransforminggrowthfactorbetareceptorsignalingpathwayuterinewallbreakdownuterusdevelopmentventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesiswoundhealing
Neurturin
164
Neurturin
164
3.2
72
0.44
NRTNNRTNQ99748Q99748MAPKcascadenervedevelopmentnervoussystemdevelopmentneuralcrestcellmigrationneuronprojectiondevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathway
Fatty acid synthase
856
Fatty acid synthase
856
3.2
75
0.41
A5YV76A5YV76A5YV76A5YV76fattyacidbiosyntheticprocess
SWI/SNF complex subunit SMARCC1
462
SWI/SNF complex subunit SMARCC1
462
3.3
56
0.54
SMRC1SMRC1Q92922Q92922animalorganmorphogenesischromatinremodelinginsulinreceptorsignalingpathwaynegativeregulationofcelldifferentiationnegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnervoussystemdevelopmentnucleosomedisassemblypositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofdouble-strandbreakrepairpositiveregulationofmyoblastdifferentiationpositiveregulationofstemcellpopulationmaintenancepositiveregulationofTcelldifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofG0toG1transitionregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofnucleotide-excisionrepairregulationoftranscriptionbyRNApolymeraseII
Cytidine deaminase
59
Cytidine deaminase
99
3.3
56
0.54
CDDCDDP32320P32320cellsurfacereceptorsignalingpathwaycellularresponsetoexternalbioticstimuluscytidinedeaminationcytosinemetabolicprocessnegativeregulationofcellgrowthnegativeregulationofnucleotidemetabolicprocesspyrimidine-containingcompoundsalvageresponsetocycloheximideUMPsalvage
Transforming growth factor beta-1 proprotein
223
Transforming growth factor beta-1 proprotein
223
3.1
71
0.45
TGFB1TGFB1P07200P07200adaptiveimmuneresponsebasedonsomaticrecombinationofimmunereceptorsbuiltfromimmunoglobulinsuperfamilydomainsaorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaybranchelongationinvolvedinmammaryglandductbranchingbronchioledevelopmentcellmigrationcellmorphogenesiscell-celljunctionorganizationcellularcalciumionhomeostasiscellularresponsetoionizingradiationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetoviruschondrocytedifferentiationcolumnar/cuboidalepithelialcellmaturationcommon-partnerSMADproteinphosphorylationembryonicliverdevelopmentenamelmineralizationendodermdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialcellproliferationepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayfacemorphogenesisgeneexpressiongermcellmigrationhematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponseLangerhanscelldifferentiationlensfibercelldifferentiationlipopolysaccharide-mediatedsignalingpathwaylungalveolusdevelopmentlymphnodedevelopmentmammaryglandbranchinginvolvedinthelarcheMAPKcascademembraneproteinintracellulardomainproteolysismusclecellcellularhomeostasisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofepithelialcellproliferationnegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofinterleukin-17productionnegativeregulationofmacrophagecytokineproductionnegativeregulationofmyoblastdifferentiationnegativeregulationofossificationnegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationofTcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneuraltubeclosureNotchsignalingpathwayoligodendrocytedevelopmentossificationinvolvedinboneremodelingosteoclastdifferentiationpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocessphospholipidhomeostasispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofhistoneacetylationpositiveregulationofhistonedeacetylationpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofodontogenesispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorclusteringpositiveregulationofregulatoryTcelldifferentiationpositiveregulationofSMADproteinsignaltransductionpositiveregulationofstemcellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofactincytoskeletonreorganizationregulationofbindingregulationofbranchinginvolvedinmammaryglandductmorphogenesisregulationofcartilagedevelopmentregulationofcellpopulationproliferationregulationofDNAbindingregulationofinterleukin-23productionregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofsodiumiontransportregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulatoryTcelldifferentiationresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductionstemcellproliferationsurfactanthomeostasisTcellhomeostasisTcellproliferationtoleranceinductiontoselfantigentransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmenturetericbuddevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
Lysine-specific histone demethylase 2
278
Lysine-specific histone demethylase 2
278
3.1
52
0.61
KDM1BKDM1BQ8NB78Q8NB78DNAmethylationinvolvedingametegenerationhistoneH3-K4demethylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNAmethylationregulationofgeneexpressionbygenomicimprinting
Transforming acidic coiled-coil-containing protein 3
828
Transforming acidic coiled-coil-containing protein 3
828
3.1
61
0.52
TACC3TACC3Q9Y6A5Q9Y6A5celldivisioncellpopulationproliferationcerebralcortexdevelopmentmetaphase/anaphasetransitionofmitoticcellcyclemicrotubulecytoskeletonorganizationmicrotubulecytoskeletonorganizationinvolvedinmitosismitoticspindleorganizationregulationofmitoticspindleorganization
NF-kappa-B essential modulator
54
NF-kappa-B essential modulator
54
3.2
48
0.66
NEMONEMOQ9Y6K9Q9Y6K9anoikisapoptoticprocesscellularresponsetoDNAdamagestimulusestablishmentofvesiclelocalizationI-kappaBkinase/NF-kappaBsignalingimmuneresponseinflammatoryresponseinnateimmuneresponsenegativeregulationofneurondeathpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofmacroautophagypositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofTcellreceptorsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIprotein-containingcomplexassemblyregulationofI-kappaBkinase/NF-kappaBsignalingresponsetovirusTcellreceptorsignalingpathway
Antiviral innate immune response receptor RIG-I
829
Antiviral innate immune response receptor RIG-I
829
3.1
65
0.49
DDX58DDX58O95786O95786antiviralinnateimmuneresponsecellularresponsetoexogenousdsRNAcytoplasmicpatternrecognitionreceptorsignalingpathwayinresponsetovirusdefenseresponsetovirusdetectionofvirusgeneexpressioninnateimmuneresponsepositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofgeneexpressionpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofmyeloiddendriticcellcytokineproductionpositiveregulationofresponsetocytokinestimuluspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionregulationofcellmigrationregulationoftypeIIIinterferonproductionresponsetoexogenousdsRNAresponsetovirusRIG-Isignalingpathway
Ketohexokinase
98
Ketohexokinase
98
3.1
92
0.35
KHKKHKP50053P50053fructosemetabolicprocessregulationofglycogenmetabolicprocessresponsetofructoseresponsetoglucoseresponsetoinsulinresponsetosucroseresponsetozincion
Filamin-A
59
Filamin-A
59
3.1
48
0.67
FLNAFLNAP21333P21333actincrosslinkformationactincytoskeletonreorganizationadenylatecyclase-inhibitingdopaminereceptorsignalingpathwayangiogenesisbloodcoagulationintrinsicpathwaybloodvesselremodelingcell-celljunctionorganizationciliumassemblycytoplasmicsequesteringofproteinearlyendosometolateendosometransportepithelialtomesenchymaltransitionestablishmentofproteinlocalizationheartmorphogenesismegakaryocytedevelopmentmitoticspindleassemblynegativeregulationofapoptoticprocessnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofneuronprojectiondevelopmentnegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIplateletaggregationpositiveregulationofaxonregenerationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofintegrin-mediatedsignalingpathwaypositiveregulationofplateletactivationpositiveregulationofpotassiumiontransmembranetransportpositiveregulationofproteinimportintonucleuspositiveregulationofsubstrateadhesion-dependentcellspreadingproteinlocalizationtocellsurfaceproteinlocalizationtoplasmamembraneproteinstabilizationreceptorclusteringregulationofactinfilamentbundleassemblyregulationofcellmigrationregulationofmembranerepolarizationduringatrialcardiacmusclecellactionpotentialregulationofmembranerepolarizationduringcardiacmusclecellactionpotentialreleaseofsequesteredcalciumionintocytosolsemaphorin-plexinsignalingpathwaysynapseorganizationtubulindeacetylationwoundhealingspreadingofcells
Potassium voltage-gated channel subfamily D member 3
131
Potassium voltage-gated channel subfamily D member 3
110
3.7
63
0.43
KCND3KCND3Q9UK17Q9UK17membranerepolarizationmembranerepolarizationduringcardiacmusclecellactionpotentialmembranerepolarizationduringventricularcardiacmusclecellactionpotentialpotassiumionexportacrossplasmamembranepotassiumiontransmembranetransportpotassiumiontransportproteinhomooligomerizationregulationofheartratebycardiacconductionregulationofiontransmembranetransportventricularcardiacmusclecellmembranerepolarization
Golgi reassembly-stacking protein 2
103
Golgin-45
393
3.7
78
0.34
GORS2GO45Q99JX3Q8R2X8celldifferentiationestablishmentofproteinlocalizationtoplasmamembraneGolgiorganizationorganelleassemblyorganelleorganizationresponsetoendoplasmicreticulumstressspermatogenesisGolgitoplasmamembraneproteintransport
Histone-lysine N-methyltransferase 2C
1060
Histone-lysine N-methyltransferase 2C
1060
3.7
64
0.42
KMT2CKMT2CQ8NEZ4Q8NEZ4chromatinorganizationhistoneH3-K4methylationhistoneH3-K4monomethylationpositiveregulationoftranscriptionbyRNApolymeraseII
Poly [ADP-ribose] polymerase 1
845
Poly [ADP-ribose] polymerase 1
845
3.7
62
0.44
PARP1PARP1P09874P09874apoptoticprocessATPgenerationfrompoly-ADP-D-ribosecellularresponsetoamyloid-betacellularresponsetoDNAdamagestimuluscellularresponsetoinsulinstimuluscellularresponsetooxidativestresscellularresponsetoUVcellularresponsetozincionDNAADP-ribosylationDNArepairdouble-strandbreakrepairmacrophagedifferentiationmitochondrialDNAmetabolicprocessmitochondrialDNArepairmitochondrionorganizationnegativeregulationofATPbiosyntheticprocessnegativeregulationoftelomeremaintenanceviatelomerelengtheningnegativeregulationoftranscriptionbyRNApolymeraseIIpeptidyl-glutamicacidpoly-ADP-ribosylationpeptidyl-serineADP-ribosylationpositiveregulationofcardiacmusclehypertrophypositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofmitochondrialdepolarizationpositiveregulationofmyofibroblastdifferentiationpositiveregulationofneurondeathpositiveregulationofproteinlocalizationtonucleuspositiveregulationofsinglestrandbreakrepairpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingproteinADP-ribosylationproteinauto-ADP-ribosylationproteinautoprocessingproteinmodificationprocessproteinpoly-ADP-ribosylationregulationofcatalyticactivityregulationofDNAmethylationregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwayregulationofproteinlocalizationregulationofSMADproteincomplexassemblyresponsetoaldosteroneresponsetogammaradiationsignaltransductioninvolvedinregulationofgeneexpressiontelomeremaintenancetranscriptionbyRNApolymeraseIItransforminggrowthfactorbetareceptorsignalingpathway
Cysteine desulfurase, mitochondrial
381
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
69
4.8
75
0.28
NFS1ISCUQ9Y697Q9H1K12Fe-2Sclusterassemblyironincorporationintometallo-sulfurclusteriron-sulfurclusterassemblyMo-molybdopterincofactorbiosyntheticprocesscellularironionhomeostasisnegativeregulationofironionimportacrossplasmamembranepositiveregulationofaconitatehydrataseactivitypositiveregulationofmitochondrialelectrontransportNADHtoubiquinone
Phosphatidylinositol 3-kinase regulatory subunit beta
396
Phosphatidylinositol 3-kinase regulatory subunit beta
396
4.0
68
0.36
P85BP85BO00459O00459BcelldifferentiationcellularglucosehomeostasiscellularresponsetoinsulinstimulusimmuneresponseinsulinreceptorsignalingpathwaynegativeregulationofMAPKcascadephosphatidylinositol3-kinasesignalingphosphatidylinositolphosphatebiosyntheticprocesspositiveregulationofcelladhesionpositiveregulationofproteinimportintonucleuspositiveregulationoftranscriptionbyRNApolymeraseIIproteintransportregulationofactinfilamentpolymerizationregulationofautophagyregulationofphosphatidylinositol3-kinaseactivityregulationofproteinlocalizationtoplasmamembraneregulationofstressfiberassemblyresponsetoendoplasmicreticulumstressTcelldifferentiation
Mothers against decapentaplegic homolog 2
380
Zinc finger FYVE domain-containing protein 9
783
5.9
69
0.25
SMAD2ZFYV9Q15796O95405activinreceptorsignalingpathwayadrenalglanddevelopmentanatomicalstructuremorphogenesisanterior/posteriorpatternspecificationBMPsignalingpathwaycelldifferentiationcellfatecommitmentcommon-partnerSMADproteinphosphorylationembryoniccranialskeletonmorphogenesisembryonicforegutmorphogenesisendodermformationgastrulationinuteroembryonicdevelopmentinsulinsecretionintracellularsignaltransductionlungdevelopmentmesodermformationnegativeregulationofcellpopulationproliferationnegativeregulationoftranscriptionDNA-templatednodalsignalingpathwayorgangrowthpancreasdevelopmentparaxialmesodermmorphogenesispericardiumdevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofgeneexpressionpositiveregulationofnodalsignalingpathwayinvolvedindeterminationoflateralmesodermleft/rightasymmetrypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpost-embryonicdevelopmentprimarymiRNAprocessingregulationofbindingregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoglucosesecondarypalatedevelopmentsignaltransductioninvolvedinregulationofgeneexpressionSMADproteincomplexassemblySMADproteinsignaltransductiontranscriptionDNA-templatedtransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentwoundhealingzygoticspecificationofdorsal/ventralaxisendocytosisendosomaltransport
C-C motif chemokine 4
34
C-C motif chemokine 4
35
10.0
75
0.13
CCL4CCL4P13236P13236celladhesioncell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwayeosinophilchemotaxisestablishmentormaintenanceofcellpolarityGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponselymphocytechemotaxismonocytechemotaxisnegativeregulationbyhostofviraltranscriptionneutrophilchemotaxispositiveregulationofcalciumiontransportpositiveregulationofcalcium-mediatedsignalingpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofnaturalkillercellchemotaxisresponsetotoxicsubstanceresponsetovirussignaltransduction
Synaptonemal complex protein 1
190
Synaptonemal complex protein 1
190
3.5
51
0.57
SYCP1SYCP1Q15431Q15431celldivisionchiasmaassemblyhomologouschromosomepairingatmeiosislateralelementassemblymeioticDNArepairsynthesisproteinhomotetramerizationreciprocalmeioticrecombinationregulationofproteinlocalizationspermDNAcondensationspermatogenesissynaptonemalcomplexassembly
Copper transport protein ATOX1
12
Copper-transporting ATPase 1
19
3.5
50
0.58
ATOX1ATP7AO00244Q04656cellularcopperionhomeostasiscopperiontransportresponsetooxidativestressbloodvesseldevelopmentbloodvesselremodelingcartilagedevelopmentcatecholaminemetabolicprocesscellularresponsetoaminoacidstimuluscellularresponsetoantibioticcellularresponsetocadmiumioncellularresponsetocobaltioncellularresponsetocopperioncellularresponsetohypoxiacellularresponsetoironioncellularresponsetoleadioncellularresponsetoplatelet-derivedgrowthfactorstimuluscentralnervoussystemneurondevelopmentcerebellarPurkinjecelldifferentiationcollagenfibrilorganizationcopperionexportcopperionhomeostasiscopperionimportdetoxificationofcopperiondopaminemetabolicprocesselasticfiberassemblyelastinbiosyntheticprocessepinephrinemetabolicprocessextracellularmatrixorganizationfemalepregnancyhairfolliclemorphogenesisinuteroembryonicdevelopmentlactationliverdevelopmentlocomotorybehaviorlungalveolusdevelopmentmitochondrionorganizationnegativeregulationofironiontransmembranetransportneuronprojectionmorphogenesisnorepinephrinemetabolicprocesspeptidyl-lysinemodificationpigmentationpositiveregulationofcatalyticactivitypositiveregulationofcellsizepositiveregulationofepithelialcellproliferationpositiveregulationoflamellipodiumassemblypositiveregulationofmelaninbiosyntheticprocesspositiveregulationofresponsetowoundingpositiveregulationoftyrosinaseactivitypositiveregulationofvascularassociatedsmoothmusclecellmigrationpyramidalneurondevelopmentregulationofcytochrome-coxidaseactivityregulationofgeneexpressionregulationofoxidativephosphorylationremovalofsuperoxideradicalsresponsetoiron(III)ionresponsetomanganeseionresponsetozincionserotoninmetabolicprocessskindevelopmentT-helpercelldifferentiationtryptophanmetabolicprocess
Inhibin beta A chain
390
Inhibin beta A chain
390
3.4
70
0.42
INHBAINHBAP08476P08476activinreceptorsignalingpathwaycelldifferentiationcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularresponsetocholesterolcellularresponsetofollicle-stimulatinghormonestimulusdefenseresponseendodermalcelldifferentiationerythrocytedifferentiationextrinsicapoptoticsignalingpathwayeyeliddevelopmentincamera-typeeyeGABAergicneurondifferentiationhairfollicledevelopmenthematopoieticprogenitorcelldifferentiationhemoglobinbiosyntheticprocessmalegonaddevelopmentmesodermalcelldifferentiationmulticellularorganismagingnegativeregulationofBcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationoffollicle-stimulatinghormonesecretionnegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofinterferon-gammaproductionnegativeregulationofmacrophagedifferentiationnegativeregulationofphosphorylationnervoussystemdevelopmentodontogenesisovarianfollicledevelopmentpositiveregulationoferythrocytedifferentiationpositiveregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandpositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofgeneexpressionpositiveregulationofovulationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprogesteronesecretionregulationoffollicle-stimulatinghormonesecretionregulationoftranscriptionbyRNApolymeraseIIresponsetoxenobioticstimulusroofofmouthdevelopmentSMADproteinsignaltransductionstriatalmediumspinyneurondifferentiationtranscriptionbyRNApolymeraseII
MHC class II HLA-DQ-alpha chain
11
MHC class II antigen
47
3.4
96
0.3
Q30066Q67AJ6Q30066Q67AJ6adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Peroxiredoxin-1
83
Peroxiredoxin-1
83
3.4
83
0.35
PRDX1PRDX1Q63716Q63716cellpopulationproliferationcellredoxhomeostasiserythrocytehomeostasishydrogenperoxidecatabolicprocessleukocyteactivationnaturalkillercellactivationnaturalkillercellmediatedcytotoxicityregulationofNIK/NF-kappaBsignalingregulationofstress-activatedMAPKcascaderemovalofsuperoxideradicalsresponsetooxidativestressresponsetoreactiveoxygenspecies
E3 SUMO-protein ligase PIAS3
201
E3 SUMO-protein ligase PIAS3
201
3.4
46
0.64
PIAS3PIAS3Q9Y6X2Q9Y6X2negativeregulationofgeneexpressionnegativeregulationofosteoclastdifferentiationnegativeregulationofproteinsumoylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofgeneexpressionpositiveregulationofmembranepotentialpositiveregulationofproteinsumoylationproteinsumoylationregulationoftranscriptionbyRNApolymeraseIIresponsetohormoneTNFSF11-mediatedsignalingpathway
Ubiquitin carboxyl-terminal hydrolase 7
315
Ubiquitin carboxyl-terminal hydrolase 7
315
5.9
56
0.3
UBP7UBP7Q93009Q93009histoneH2BconservedC-terminallysinedeubiquitinationmaintenanceofDNAmethylationmonoubiquitinatedproteindeubiquitinationnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofDNAdemethylationproteindeubiquitinationproteinK63-linkeddeubiquitinationproteinstabilizationproteinubiquitinationregulationofcircadianrhythmregulationofDNA-bindingtranscriptionfactoractivityregulationofgluconeogenesisregulationofproteinstabilityregulationofretrogradetransportendosometoGolgiregulationofsignaltransductionbyp53classmediatorregulationoftelomerecappingrhythmicprocesstranscription-couplednucleotide-excisionrepairubiquitin-dependentproteincatabolicprocess
MORC family CW-type zinc finger protein 3
446
MORC family CW-type zinc finger protein 3
413
5.9
75
0.23
MORC3MORC3Q14149Q14149innateimmuneresponsemaintenanceofproteinlocationinnucleusnegativeregulationoffibroblastproliferationpeptidyl-serinephosphorylationpositiveregulationofcellularsenescencepost-embryonicdevelopmentproteinphosphorylationproteinstabilization
Probable tRNA(His) guanylyltransferase
51
Probable tRNA(His) guanylyltransferase
51
5.6
72
0.25
THG1THG1Q9NWX6Q9NWX6mitochondrialfusionproteinhomotetramerizationresponsetooxidativestressstress-inducedmitochondrialfusiontRNAmodificationtRNAprocessing
Bifunctional peptidase and arginyl-hydroxylase JMJD5
232
Bifunctional peptidase and arginyl-hydroxylase JMJD5
232
4.0
65
0.38
KDM8KDM8Q8N371Q8N371chromatinorganizationcircadianregulationofgeneexpressionG2/MtransitionofmitoticcellcyclehistoneH3-K36demethylationnegativeregulationoftranscriptionDNA-templatedpositiveregulationoftranscriptionDNA-templatedproteindestabilizationproteolysis
N-lysine methyltransferase KMT5A
311
N-lysine methyltransferase KMT5A
311
3.5
62
0.47
KMT5AKMT5AQ9NQR1Q9NQR1celldivisionchromatinorganizationhistoneH4-K20monomethylationmitoticchromosomecondensationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpeptidyl-lysinemonomethylationregulationofDNAdamageresponsesignaltransductionbyp53classmediatorregulationofsignaltransductionbyp53classmediatorregulationoftranscriptionbyRNApolymeraseII
Hepatocyte growth factor
129
Hepatocyte growth factor
129
3.5
82
0.35
HGFHGFQ08048Q08048animalorganregenerationcellchemotaxiscellmorphogenesiscellularresponsetohepatocytegrowthfactorstimulusepithelialcellproliferationhepatocytegrowthfactorreceptorsignalingpathwayliverdevelopmentmyoblastproliferationnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-6productionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofreleaseofcytochromecfrommitochondriapositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofinterleukin-10productionpositiveregulationofMAPKcascadepositiveregulationofmyelinationpositiveregulationofneuronprojectionregenerationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationproteolysisregulationofbranchinginvolvedinsalivaryglandmorphogenesisbymesenchymal-epithelialsignalingregulationofp38MAPKcascaderegulationoftau-proteinkinaseactivityskeletalmusclecellproliferation
NAD-dependent protein deacetylase sirtuin-1
380
NAD-dependent protein deacetylase sirtuin-1
380
3.5
74
0.39
SIR1SIR1Q96EB6Q96EB6angiogenesisbehavioralresponsetostarvationcellularglucosehomeostasiscellularresponsetoDNAdamagestimuluscellularresponsetoglucosestarvationcellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetoionizingradiationcellularresponsetoleukemiainhibitoryfactorcellularresponsetostarvationcellularresponsetotumornecrosisfactorcellulartriglyceridehomeostasischolesterolhomeostasischromatinorganizationcircadianregulationofgeneexpressionDNAmethylation-dependentheterochromatinassemblyDNAsynthesisinvolvedinDNArepairenergyhomeostasisfattyacidhomeostasisheterochromatinassemblyhistonedeacetylationhistoneH3deacetylationintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorleptin-mediatedsignalingpathwaymacrophagedifferentiationmuscleorgandevelopmentnegativeregulationofandrogenreceptorsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofcAMP-dependentproteinkinaseactivitynegativeregulationofcellcyclenegativeregulationofcellgrowthnegativeregulationofcellularresponsetotestosteronestimulusnegativeregulationofcellularsenescencenegativeregulationofDNAdamageresponsesignaltransductionbyp53classmediatornegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhelicaseactivitynegativeregulationofhistoneH3-K14acetylationnegativeregulationofhistoneH3-K9trimethylationnegativeregulationofhistoneH4-K16acetylationnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatornegativeregulationofneurondeathnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofpeptidyl-lysineacetylationnegativeregulationofphosphorylationnegativeregulationofprostaglandinbiosyntheticprocessnegativeregulationofproteinacetylationnegativeregulationofproteinkinaseBsignalingnegativeregulationofTORsignalingnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayovulationfromovarianfolliclepeptidyl-lysineacetylationpeptidyl-lysinedeacetylationpositiveregulationofadaptiveimmuneresponsepositiveregulationofadiposetissuedevelopmentpositiveregulationofangiogenesispositiveregulationofapoptoticprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcAMP-dependentproteinkinaseactivitypositiveregulationofcellpopulationproliferationpositiveregulationofcellularsenescencepositiveregulationofcholesteroleffluxpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofDNArepairpositiveregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwaypositiveregulationofendothelialcellproliferationpositiveregulationofgluconeogenesispositiveregulationofhistonedeacetylationpositiveregulationofhistoneH3-K9methylationpositiveregulationofhistonemethylationpositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofmacroautophagypositiveregulationofmacrophageapoptoticprocesspositiveregulationofmacrophagecytokineproductionpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationpositiveregulationofsmoothmusclecelldifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindeacetylationproteindepropionylationproteindestabilizationproteinubiquitinationpyrimidinedimerrepairbynucleotide-excisionrepairrDNAheterochromatinassemblyregulationofapoptoticprocessregulationofbileacidbiosyntheticprocessregulationofbrownfatcelldifferentiationregulationofcellpopulationproliferationregulationofcellularresponsetoheatregulationofcentrosomeduplicationregulationofendodeoxyribonucleaseactivityregulationofglucosemetabolicprocessregulationoflipidstorageregulationofmitoticcellcycleregulationofperoxisomeproliferatoractivatedreceptorsignalingpathwayregulationofproteinserine/threoninekinaseactivityregulationofsmoothmusclecellapoptoticprocessregulationoftranscriptionbyglucoseresponsetohydrogenperoxideresponsetoinsulinresponsetoleptinresponsetooxidativestresssinglestrandbreakrepairspermatogenesisstress-inducedprematuresenescencetransforminggrowthfactorbetareceptorsignalingpathwaytriglyceridemobilizationUV-damageexcisionrepairwhitefatcelldifferentiation
Plexin-B2
1508
Plexin-B2
1508
3.6
34
0.83
PLXB2PLXB2B2RXS4B2RXS4braindevelopmentexcitatorysynapseassemblyhomophiliccelladhesionviaplasmamembraneadhesionmoleculesnegativeregulationofcelladhesionneuraltubeclosureneuroblastproliferationpositiveregulationofaxonogenesispositiveregulationofneuronprojectiondevelopmentpositiveregulationoftranslationregulationofcellmigrationregulationofcellshaperegulationofGTPaseactivityregulationofneuronmigrationregulationofproteinphosphorylationsemaphorin-plexinsignalingpathwaysemaphorin-plexinsignalingpathwayinvolvedinaxonguidance
Protein fem-1 homolog B
186
Folliculin-interacting protein 1
613
3.5
56
0.51
FEM1BFNIP1Q9Z2G0Q68FD7apoptoticprocessbranchinginvolvedinprostateglandmorphogenesisepithelialcellmaturationepithelialcellmaturationinvolvedinprostateglanddevelopmentproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitinationregulationofDNAdamagecheckpointregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsregulationofubiquitin-proteintransferaseactivityubiquitin-dependentproteincatabolicprocessviatheC-enddegronrulepathwayBcellapoptoticprocesscellularresponsetostarvationimmatureBcelldifferentiationnegativeregulationofcellpopulationproliferationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofTORsignalingnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofBcellapoptoticprocesspositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofTORsignalingregulationofpro-BcelldifferentiationregulationofproteinphosphorylationTORsignaling
Ganglioside-induced differentiation-associated protein 1
88
Ganglioside-induced differentiation-associated protein 1
88
3.0
70
0.47
GDAP1GDAP1Q8TB36Q8TB36cellularresponsetovitaminDglutathionemetabolicprocessmitochondrialfissionmitochondrialfusionproteintargetingtomitochondrionresponsetoretinoicacid
Galactokinase
391
Galactokinase
391
3.1
74
0.44
GALK1GALK1P51570P51570galactitolmetabolicprocessgalactosecatabolicprocessgalactosecatabolicprocessviaUDP-galactosegalactosemetabolicprocessglycolyticprocessfromgalactose
Phenylethanolamine N-methyltransferase
139
Phenylethanolamine N-methyltransferase
48
3.1
65
0.5
PNMTPNMTP11086P11086catecholaminebiosyntheticprocessepinephrinebiosyntheticprocessmethylation
Talin-1
575
Talin-1
575
3.1
66
0.49
TLN1TLN1P26039P26039cell-celladhesioncell-substratejunctionassemblycorticalactincytoskeletonorganizationintegrinactivationintegrin-mediatedsignalingpathway
Pyrroline-5-carboxylate reductase 2
225
Pyrroline-5-carboxylate reductase 2
225
3.5
78
0.36
P5CR2P5CR2Q96C36Q96C36cellularresponsetooxidativestressL-prolinebiosyntheticprocessprolinebiosyntheticprocess
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
119
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
119
3.4
86
0.34
CD38CD38P28907P28907apoptoticsignalingpathwayarterysmoothmusclecontractionBcellproliferationBcellreceptorsignalingpathwayfemalepregnancylong-termsynapticdepressionNADmetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofboneresorptionnegativeregulationofneuronprojectiondevelopmentnegativeregulationoftranscriptionDNA-templatedpositiveregulationofBcellproliferationpositiveregulationofcellgrowthpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofinsulinsecretionpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvasoconstrictionresponsetoestradiolresponsetohydroperoxideresponsetohypoxiaresponsetointerleukin-1responsetoprogesteroneresponsetoretinoicacidresponsetoxenobioticstimulussignaltransduction
Ketimine reductase mu-crystallin
283
Ketimine reductase mu-crystallin
283
3.4
86
0.34
CRYMCRYMO54983O54983mitochondrialtransportnegativeregulationoftranscriptionbyRNApolymeraseIIsensoryperceptionofsoundthyroidhormonemetabolicprocessthyroidhormonetransport
DNA repair protein RAD50
684
DNA repair protein RAD50
681
3.5
67
0.43
RAD50RAD50Q92878Q92878cellularresponsetoDNAdamagestimuluschromosomeorganizationinvolvedinmeioticcellcycleDNAdouble-strandbreakprocessingDNAduplexunwindingDNArecombinationDNArepairDNAstrandresectioninvolvedinreplicationforkprocessingdouble-strandbreakrepairhomologousrecombinationmitoticG2/Mtransitioncheckpointnegativeregulationoftelomerecappingnucleicacidphosphodiesterbondhydrolysispositiveregulationofkinaseactivitypositiveregulationofproteinautophosphorylationpositiveregulationoftelomeremaintenancereciprocalmeioticrecombinationregulationofmitoticrecombinationtelomeremaintenancetelomeremaintenanceviarecombinationtelomeremaintenanceviatelomerase"telomeric3overhangformation"
F-box/WD repeat-containing protein 1A
137
F-box/WD repeat-containing protein 1A
137
3.5
64
0.44
FBW1AFBW1AQ9Y297Q9Y297branchinginvolvedinmammaryglandductmorphogenesiscellularresponsetoorganiccycliccompoundmammaryglandepithelialcellproliferationnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofsmoothenedsignalingpathwaynegativeregulationoftranscriptionDNA-templatedpositiveregulationofcircadianrhythmpositiveregulationofproteolysispositiveregulationoftranscriptionDNA-templatedpositiveregulationofubiquitinproteinligaseactivityproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindephosphorylationproteindestabilizationproteinK48-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationofcanonicalWntsignalingpathwayregulationofcellcycleregulationofcircadianrhythmregulationofI-kappaBkinase/NF-kappaBsignalingregulationofproteasomalproteincatabolicprocessrhythmicprocessSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocesssignaltransductionubiquitin-dependentproteincatabolicprocessWntsignalingpathway
DNA repair protein RAD50
684
DNA repair protein RAD50
684
3.6
64
0.44
RAD50RAD50Q92878Q92878cellularresponsetoDNAdamagestimuluschromosomeorganizationinvolvedinmeioticcellcycleDNAdouble-strandbreakprocessingDNAduplexunwindingDNArecombinationDNArepairDNAstrandresectioninvolvedinreplicationforkprocessingdouble-strandbreakrepairhomologousrecombinationmitoticG2/Mtransitioncheckpointnegativeregulationoftelomerecappingnucleicacidphosphodiesterbondhydrolysispositiveregulationofkinaseactivitypositiveregulationofproteinautophosphorylationpositiveregulationoftelomeremaintenancereciprocalmeioticrecombinationregulationofmitoticrecombinationtelomeremaintenancetelomeremaintenanceviarecombinationtelomeremaintenanceviatelomerase"telomeric3overhangformation"
Dual specificity protein phosphatase 5
251
Dual specificity protein phosphatase 5
251
3.6
63
0.44
DUS5DUS5Q16690Q16690dephosphorylationendodermformationERK1andERK2cascadeMAPKcascadenegativeregulationofMAPKcascadepeptidyl-threoninedephosphorylationpeptidyl-tyrosinedephosphorylationproteindephosphorylation
Interferon lambda-3
69
Interferon lambda-3
69
3.5
57
0.49
IFNL3IFNL3Q8IZI9Q8IZI9cellularresponsetovirusdefenseresponsetovirusinnateimmuneresponsenegativeregulationofviralgenomereplicationpositiveregulationofimmuneresponsereceptorsignalingpathwayviaJAK-STATtypeIIIinterferonsignalingpathway
Growth/differentiation factor 8
340
Growth/differentiation factor 8
310
9.4
89
0.12
GDF8GDF8O08689O08689cellularresponsetodexamethasonestimulusmusclecellcellularhomeostasismyoblastmigrationinvolvedinskeletalmuscleregenerationnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofkinaseactivitynegativeregulationofmusclehypertrophynegativeregulationofmyoblastdifferentiationnegativeregulationofmyoblastproliferationnegativeregulationofproteinkinaseBsignalingnegativeregulationofsatellitecelldifferentiationnegativeregulationofskeletalmusclesatellitecellproliferationnegativeregulationofskeletalmuscletissuegrowthovulationcycleprocesspositiveregulationoflamellipodiumassemblypositiveregulationofmacrophagechemotaxispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionDNA-templatedresponsetoelectricalstimulusresponsetoestrogenresponsetoethanolresponsetogravityresponsetoheatresponsetomuscleactivityresponsetotestosteroneskeletalmuscleatrophySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Transforming growth factor beta-2 proprotein
411
Transforming growth factor beta-2 proprotein
379
9.4
86
0.12
TGFB2TGFB2P61812P61812activationofproteinkinaseactivityascendingaortamorphogenesisatrialseptummorphogenesisatrialseptumprimummorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwaycardiacepithelialtomesenchymaltransitioncardiacmusclecellproliferationcardiacrightventriclemorphogenesiscardioblastdifferentiationcelldeathcellmigrationcellmorphogenesiscell-celljunctionorganizationcollagenfibrilorganizationcranialskeletalsystemdevelopmentdopaminebiosyntheticprocessembryodevelopmentendinginbirthoregghatchingembryonicdigestivetractdevelopmentembryoniclimbmorphogenesisendocardialcushionfusionendocardialcushionmorphogenesisepithelialtomesenchymaltransitionextrinsicapoptoticsignalingpathwayeyedevelopmentgenerationofneuronsglialcellmigrationhairfollicledevelopmenthairfolliclemorphogenesisheartdevelopmentheartmorphogenesisheartvalvemorphogenesishemopoiesisinnereardevelopmentkidneydevelopmentmalegonaddevelopmentmembranousseptummorphogenesisnegativeregulationofalkalinephosphataseactivitynegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofepithelialcellproliferationnegativeregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationnegativeregulationofgeneexpressionnegativeregulationofmacrophagecytokineproductionnegativeregulationofRasproteinsignaltransductionneuralretinadevelopmentneuraltubeclosureneurondevelopmentneutrophilchemotaxisodontogenesisoutflowtractseptummorphogenesispathway-restrictedSMADproteinphosphorylationpharyngealarcharterymorphogenesispositiveregulationofcardioblastdifferentiationpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcellcyclepositiveregulationofcelldivisionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationpositiveregulationofheartcontractionpositiveregulationofimmuneresponsepositiveregulationofintegrinbiosyntheticprocesspositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationofNotchsignalingpathwaypositiveregulationofossificationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofstress-activatedMAPKcascadepositiveregulationoftimingofcatagenproteinphosphorylationpulmonaryvalvemorphogenesisregulationofapoptoticprocessinvolvedinoutflowtractmorphogenesisregulationofcellpopulationproliferationregulationoftimingofcatagenregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetoprogesteroneresponsetowoundingresponsetoxenobioticstimulussalivaryglandmorphogenesissecondarypalatedevelopmentskeletalsystemdevelopmentSMADproteinsignaltransductionsomaticstemcelldivisionsubstantiapropriaofcorneadevelopmenttransforminggrowthfactorbetareceptorsignalingpathwayuterinewallbreakdownuterusdevelopmentventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesiswoundhealing
Chymotrypsinogen A
42
Amyloid-beta precursor protein
300
9.1
101
0.11
CTRAA4P00766P05067digestionproteolysisadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Glutamate receptor ionotropic, kainate 5
83
Glutamate receptor ionotropic, kainate 2
347
9.1
59
0.19
GRIK5GRIK2Q63273P42260cellularresponsetoglucosestimuluschemicalsynaptictransmissionestablishmentoflocalizationincellexcitatorypostsynapticpotentialmodulationofchemicalsynaptictransmissionpositiveregulationofneuronapoptoticprocessproteinretentioninERlumenreceptorclusteringregulationofmembranepotentialregulationofsynapticvesiclefusiontopresynapticactivezonemembranesynaptictransmissionglutamatergicbehavioralfearresponsecellularcalciumionhomeostasisdetectionofcoldstimulusinvolvedinthermoceptioninhibitorypostsynapticpotentialnegativeregulationofneuronapoptoticprocessnegativeregulationofsynaptictransmissionglutamatergicneuronapoptoticprocessneuronalactionpotentialpositiveregulationofsynaptictransmissionpresynapticmodulationofchemicalsynaptictransmissionregulationofJNKcascaderegulationoflong-termneuronalsynapticplasticityregulationofshort-termneuronalsynapticplasticity
Anionic trypsin-2
48
Pancreatic trypsin inhibitor
49
9.1
97
0.11
TRY2BPT1P00763P00974collagencatabolicprocessdigestionproteolysisresponsetonutrientnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Hemoglobin subunit alpha
105
Hemoglobin subunit beta
113
9.1
87
0.13
HBAA0A481SHK9P69905A0A481SHK9carbondioxidetransportcellularoxidantdetoxificationhydrogenperoxidecatabolicprocessnitricoxidetransportoxygentransportpositiveregulationofcelldeathresponsetohydrogenperoxide
Insulin
96
Insulin
96
9.1
51
0.22
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
Xanthine dehydrogenase/oxidase
78
Xanthine dehydrogenase/oxidase
280
9.1
88
0.12
XDHXDHP80457P80457xanthinecatabolicprocess
Neurturin
134
Neurturin
164
9.1
65
0.17
NRTNNRTNQ99748Q99748MAPKcascadenervedevelopmentnervoussystemdevelopmentneuralcrestcellmigrationneuronprojectiondevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathway
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
25
Guanine nucleotide-binding protein G(T) subunit gamma-T1
36
9.1
58
0.19
GBB1GBG1P62871P02698adenylatecyclase-activatingdopaminereceptorsignalingpathwaycellularresponsetocatecholaminestimuluscellularresponsetoprostaglandinEstimulusGprotein-coupledreceptorsignalingpathway
Albumin
537
Albumin
582
9.1
74
0.15
ALBUALBUP02769P02769cellularresponsetostarvationmaintenanceofmitochondrionlocationnegativeregulationofapoptoticprocess
Glycine--tRNA ligase
155
Glycine--tRNA ligase
180
9.1
78
0.14
GARSGARSP41250P41250diadenosinetetraphosphatebiosyntheticprocessglycyl-tRNAaminoacylationmitochondrialglycyl-tRNAaminoacylationtRNAaminoacylationforproteintranslation
C-C motif chemokine 17
73
C-C motif chemokine 17
57
9.1
54
0.2
CCL17CCL17Q92583Q92583antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisnegativeregulationofmyoblastdifferentiationneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
Cytochrome c oxidase subunit 6B1
40
Cytochrome c oxidase subunit 6B1
40
9.1
60
0.18
CX6B1CX6B1P00429P00429oxidativephosphorylation
Hemoglobin subunit alpha
111
Hemoglobin subunit beta
112
9.1
77
0.14
HBAHBBP60529P60524cellularoxidantdetoxificationhydrogenperoxidecatabolicprocess
Tumor necrosis factor ligand superfamily member 13
187
Tumor necrosis factor ligand superfamily member 13
187
9.8
90
0.11
TNF13TNF13Q9D777Q9D777germinalcenterformationimmunoglobulinmediatedimmuneresponsepositiveregulationofcellpopulationproliferationpositiveregulationofgerminalcenterformationpositiveregulationofisotypeswitchingtoIgAisotypesregulationofimmuneresponse
Growth/differentiation factor 8
339
Growth/differentiation factor 8
340
9.1
74
0.15
GDF8GDF8O14793O14793cellularresponsetodexamethasonestimulusmusclecellcellularhomeostasismuscleorgandevelopmentmyoblastmigrationinvolvedinskeletalmuscleregenerationnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofkinaseactivitynegativeregulationofmusclehypertrophynegativeregulationofmyoblastdifferentiationnegativeregulationofmyoblastproliferationnegativeregulationofproteinkinaseBsignalingnegativeregulationofsatellitecelldifferentiationnegativeregulationofskeletalmusclesatellitecellproliferationnegativeregulationofskeletalmuscletissuegrowthovulationcycleprocesspositiveregulationoflamellipodiumassemblypositiveregulationofmacrophagechemotaxispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionDNA-templatedresponsetoelectricalstimulusresponsetoestrogenresponsetoethanolresponsetogravityresponsetoheatresponsetomuscleactivityresponsetotestosteroneskeletalmuscleatrophySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Anionic trypsin-2
48
Amyloid-beta precursor protein
300
9.1
95
0.12
TRY2A4P00763P05067collagencatabolicprocessdigestionproteolysisresponsetonutrientadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Histone deacetylase 6
1148
Histone deacetylase 6
1145
9.1
88
0.12
HDAC6HDAC6Q9UBN7Q9UBN7aggresomeassemblyautophagyaxonaltransportofmitochondrioncellularresponsetohydrogenperoxidecellularresponsetomisfoldedproteincellularresponsetotopologicallyincorrectproteinciliumassemblyciliumdisassemblycollateralsproutingdendriticspinemorphogenesishistonedeacetylationHsp90deacetylationintracellularproteintransportlysosomelocalizationnegativeregulationofhydrogenperoxidemetabolicprocessnegativeregulationofmicrotubuledepolymerizationnegativeregulationofoxidoreductaseactivitynegativeregulationofprotein-containingcomplexassemblynegativeregulationofprotein-containingcomplexdisassemblynegativeregulationofproteolysisnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedparkin-mediatedstimulationofmitophagyinresponsetomitochondrialdepolarizationpeptidyl-lysinedeacetylationpolyubiquitinatedmisfoldedproteintransportpositiveregulationofepithelialcellmigrationpositiveregulationofhydrogenperoxide-mediatedprogrammedcelldeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsignalingreceptoractivityproteindeacetylationproteindestabilizationproteinpolyubiquitinationproteinqualitycontrolformisfoldedorincompletelysynthesizedproteinsprotein-containingcomplexdisassemblyregulationofandrogenreceptorsignalingpathwayregulationofautophagyregulationofautophagyofmitochondrionregulationofestablishmentofproteinlocalizationregulationoffatcelldifferentiationregulationofgeneexpressionepigeneticregulationofmacroautophagyregulationofmicrotubule-basedmovementregulationofproteinstabilityresponsetogrowthfactorresponsetomisfoldedproteintubulindeacetylationubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathway
Tumor necrosis factor receptor superfamily member 14
75
Tumor necrosis factor receptor superfamily member 14
127
9.1
72
0.15
TNR14TNR14Q92956Q92956adaptiveimmuneresponsecellsurfacereceptorsignalingpathwaydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumimmuneresponseinnateimmuneresponsenegativeregulationofadaptiveimmunememoryresponsenegativeregulationofalpha-betaTcellproliferationpositiveregulationofcytokineproductioninvolvedinimmuneresponsepositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofTcellmigrationTcellcostimulation
Estrogen receptor
237
Estrogen receptor
221
9.1
68
0.16
ESR1ESR1P03372P03372androgenmetabolicprocessantralovarianfolliclegrowthcellularresponsetoestradiolstimuluscellularresponsetoestrogenstimuluschromatinremodelingepithelialcelldevelopmentepithelialcellproliferationinvolvedinmammaryglandductelongationfibroblastproliferationintracellularestrogenreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaymalegonaddevelopmentmammaryglandalveolusdevelopmentmammaryglandbranchinginvolvedinpregnancynegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofgeneexpressionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofmiRNAmaturationnegativeregulationoftranscriptionbyRNApolymeraseIIphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoffibroblastproliferationpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofphospholipaseCactivitypositiveregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprostateepithelialcordarborizationinvolvedinprostateglandularacinusmorphogenesisprostateepithelialcordelongationproteinlocalizationtochromatinregulationofbranchinginvolvedinprostateglandmorphogenesisregulationofepithelialcellapoptoticprocessregulationofinflammatoryresponseregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetoestradiolresponsetoestrogensignaltransductionstemcelldifferentiationtranscriptionbyRNApolymeraseIIuterusdevelopmentvaginadevelopment
Protection of telomeres protein 1
385
Adrenocortical dysplasia protein homolog
228
9.1
53
0.21
POTE1ACDQ9NUX5Q96AP0DNAduplexunwindingestablishmentofproteinlocalizationtotelomerenegativeregulationoftelomeraseactivitynegativeregulationoftelomeremaintenanceviatelomerasepositiveregulationofDNAhelicaseactivitypositiveregulationofDNAstrandelongationpositiveregulationofhelicaseactivitypositiveregulationoftelomeraseactivitypositiveregulationoftelomeremaintenancepositiveregulationoftelomeremaintenanceviatelomeraseregulationofDNAhelicaseactivityregulationofdouble-strandbreakrepairvianonhomologousendjoiningregulationoftelomeremaintenanceviatelomerasetelomereassemblytelomerecappingtelomeremaintenanceviatelomerasetelomericD-loopdisassemblyembryoniclimbmorphogenesisintracellularproteintransportpositiveregulationofsingle-strandedtelomericDNAbindingprotectionfromnon-homologousendjoiningattelomereproteinlocalizationtochromosometelomericregionsegmentationskeletalsystemdevelopmenttelomeremaintenanceurogenitalsystemdevelopment
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
122
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
122
9.1
77
0.14
AADATAADATQ8N5Z0Q8N5Z02-oxoglutaratemetabolicprocessalpha-aminoacidmetabolicprocessbiosyntheticprocessglutamatemetabolicprocesskynureninemetabolicprocessL-lysinecatabolicprocesstoacetyl-CoAviasaccharopine
Cytochrome c, somatic
18
Cytochrome c, somatic
18
9.1
54
0.2
CYCCYCP62898P62898activationofcysteine-typeendopeptidaseactivityactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessbycytochromecapoptoticprocessglialcellapoptoticprocesshydrogenperoxidemetabolicprocessmitochondrialelectrontransportcytochromectooxygenmitochondrialelectrontransportubiquinoltocytochromecnegativeregulationofhydrogenperoxidebiosyntheticprocesspositiveregulationofcellularrespirationpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessregulationofproteinbindingresponsetocarbonmonoxideresponsetocopperionresponsetogravityresponsetoischemiaresponsetooxidativestress
E3 ubiquitin-protein ligase RNF31
885
E3 ubiquitin-protein ligase RNF31
885
9.1
42
0.26
RNF31RNF31Q96EP0Q96EP0CD40signalingpathwaydefenseresponsetobacteriumnegativeregulationofnecroptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteintargetingtomitochondrionpositiveregulationofxenophagyproteinlinearpolyubiquitinationproteinpolyubiquitinationTcellreceptorsignalingpathway
Pyruvate kinase PKLR
74
Pyruvate kinase PKLR
360
9.1
79
0.14
KPYRKPYRO75758O75758ATPbiosyntheticprocesscellularresponsetoepinephrinestimuluscellularresponsetoinsulinstimulusglycolyticprocesspyruvatebiosyntheticprocessresponsetoATPresponsetocAMPresponsetoglucoseresponsetoheatresponsetohypoxiaresponsetolithiumionresponsetonutrient
Angiopoietin-related protein 2
443
Angiopoietin-related protein 2
443
9.1
85
0.13
ANGL2ANGL2Q9UKU9Q9UKU9cell-cellsignaling
Actin-related protein 2/3 complex subunit 1B
265
Actin-related protein 2/3 complex subunit 4
21
9.1
92
0.12
ARC1BARPC4Q58CQ2Q148J6Arp2/3complex-mediatedactinnucleationregulationofactinfilamentpolymerizationactinfilamentpolymerization
Caspase-9
403
Caspase-9
403
9.1
86
0.13
CASP9CASP9P55211P55211activationofcysteine-typeendopeptidaseactivityactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessbycytochromecagingapoptoticprocesscellularresponsetodexamethasonestimuluscellularresponsetoDNAdamagestimuluscellularresponsetoUVepithelialcellapoptoticprocessfibroblastapoptoticprocessglialcellapoptoticprocessintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagekidneydevelopmentleukocyteapoptoticprocessneuronapoptoticprocessplateletformationpositiveregulationofapoptoticprocesspositiveregulationofneuronapoptoticprocessregulationofresponsetoDNAdamagestimulusresponsetoantibioticresponsetocobaltionresponsetoestradiolresponsetoischemiaresponsetolipopolysaccharidesignaltransductioninresponsetoDNAdamage
Gem-associated protein 5
867
Gem-associated protein 5
1045
9.4
90
0.12
GEMI5GEMI5Q8TEQ6Q8TEQ6mRNAsplicingviaspliceosomeprotein-containingcomplexassemblyregulationoftranslationspliceosomalsnRNPassemblytranslation
Seminal ribonuclease
58
Seminal ribonuclease
121
9.8
62
0.16
RNSRNSP00669P00669defenseresponsetoGram-positivebacteriumRNAphosphodiesterbondhydrolysis
Albumin
537
Albumin
537
9.8
67
0.15
ALBUALBUP02769P02769cellularresponsetostarvationmaintenanceofmitochondrionlocationnegativeregulationofapoptoticprocess
Growth/differentiation factor 2
392
Growth/differentiation factor 2
428
9.8
90
0.11
GDF2GDF2Q9UK05Q9UK05activinreceptorsignalingpathwayangiogenesisbloodvesselmorphogenesisBMPsignalingpathwaybranchinginvolvedinbloodvesselmorphogenesiscartilagedevelopmentcellularironionhomeostasiscellularresponsetoBMPstimulusnegativeregulationofangiogenesisnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellgrowthnegativeregulationofDNAbiosyntheticprocessnegativeregulationofDNAreplicationnegativeregulationofendothelialcellmigrationnegativeregulationofendothelialcellproliferationossificationosteoblastdifferentiationpathway-restrictedSMADproteinphosphorylationpositiveregulationofangiogenesispositiveregulationofBMPsignalingpathwaypositiveregulationofcartilagedevelopmentpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofinterleukin-8productionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedSMADproteinsignaltransductiontranscriptionbyRNApolymeraseIIvasculogenesis
Protein arginine N-methyltransferase 5
22
Methylosome protein 50
53
9.8
74
0.14
ANM5MEP50O14744Q9BQA1chromatinorganizationcircadianregulationofgeneexpressionDNA-templatedtranscriptionterminationendothelialcellactivationGolgiribbonformationhistoneargininemethylationhistoneH4-R3methylationliverregenerationnegativeregulationofcelldifferentiationpeptidyl-argininemethylationpeptidyl-arginineN-methylationpositiveregulationofadenylatecyclase-inhibitingdopaminereceptorsignalingpathwaypositiveregulationofmRNAsplicingviaspliceosomepositiveregulationofoligodendrocytedifferentiationregulationofDNAmethylationregulationofERK1andERK2cascaderegulationofmitoticnucleardivisionregulationofsignaltransductionbyp53classmediatorregulationoftranscriptionDNA-templatedspliceosomalsnRNPassemblyepithelialcellproliferationinvolvedinprostateglanddevelopmentnegativeregulationofepithelialcellproliferationinvolvedinprostateglanddevelopmentoocyteaxisspecificationpositiveregulationofcellpopulationproliferationregulationoftranscriptionbyRNApolymeraseIIsecretorycolumnalluminarepithelialcelldifferentiationinvolvedinprostateglandularacinusdevelopment
DNA (cytosine-5)-methyltransferase 3A
540
DNA (cytosine-5)-methyltransferase 3A
494
9.8
88
0.12
DNM3ADNM3AQ9Y6K1Q9Y6K1agingC-5methylationofcytosinecellularresponsetoaminoacidstimuluscellularresponsetobisphenolAcellularresponsetoethanolcellularresponsetohypoxiaDNAmethylationDNAmethylationinvolvedinembryodevelopmentDNAmethylationinvolvedingametegenerationDNAmethylationoncytosineDNAmethylation-dependentheterochromatinassemblyhepatocyteapoptoticprocessmitoticcellcyclenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneurondifferentiationpositiveregulationofcelldeathregulationofgeneexpressionbygenomicimprintingresponsetococaineresponsetoestradiolresponsetoionizingradiationresponsetoleadionresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulusspermatogenesis
Male-specific lethal 1 homolog
221
E3 ubiquitin-protein ligase MSL2
107
9.8
57
0.18
MSL1MSL2Q68DK7Q9HCI7chromatinorganizationhistoneH4-K16acetylationpositiveregulationoftranscriptionDNA-templatedregulationofdosagecompensationbyinactivationofXchromosomeproteinubiquitination
Protein S100-A4
86
Protein S100-A4
76
9.8
62
0.16
S10A4S10A4P26447P26447epithelialtomesenchymaltransitionpositiveregulationofI-kappaBkinase/NF-kappaBsignaling
Tumor necrosis factor ligand superfamily member 13
202
Tumor necrosis factor ligand superfamily member 13
202
9.8
99
0.1
TNF13TNF13Q9D777Q9D777germinalcenterformationimmunoglobulinmediatedimmuneresponsepositiveregulationofcellpopulationproliferationpositiveregulationofgerminalcenterformationpositiveregulationofisotypeswitchingtoIgAisotypesregulationofimmuneresponse
Methylglutaconyl-CoA hydratase, mitochondrial
311
Methylglutaconyl-CoA hydratase, mitochondrial
311
9.8
89
0.11
AUHMAUHMQ13825Q13825fattyacidbeta-oxidationleucinecatabolicprocess
Glucocorticoid receptor
492
Glucocorticoid receptor
476
9.8
72
0.14
GCRGCRP06536P06536adrenalglanddevelopmentagingandrogenmetabolicprocessbraindevelopmentcellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetomagnesiumioncellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinremodelingcircadianrhythmepigeneticmaintenanceofchromatinintranscription-competentconformationfemalepregnancyglucocorticoidmetabolicprocessglucocorticoidreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaylungdevelopmentmammaryglandductmorphogenesismaternalbehaviormuscleatrophynegativeregulationofapoptoticprocessnegativeregulationofsynapticplasticitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationofvascularpermeabilitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofdendriticspinedevelopmentpositiveregulationofglucocorticoidreceptorsignalingpathwaypositiveregulationofglutamatesecretionpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprotein-containingcomplexassemblyregulationofcellpopulationproliferationregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationofglucosemetabolicprocessregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetoactivityresponsetoarsenic-containingsubstanceresponsetocalciumionresponsetocorticosteroneresponsetodexamethasoneresponsetoelectricalstimulusresponsetoinactivityresponsetoinsulinresponsetomercuryionresponsetoradiation
Guanidinoacetate N-methyltransferase
220
Guanidinoacetate N-methyltransferase
220
9.8
62
0.16
GAMTGAMTP10868P10868animalorganmorphogenesiscreatinebiosyntheticprocessembryonicliverdevelopmentmethylationregulationofmulticellularorganismgrowthS-adenosylhomocysteinemetabolicprocessS-adenosylmethioninemetabolicprocessspermatogenesis
Glutathione S-transferase Mu 1
87
Glutathione S-transferase Mu 1
78
9.8
78
0.13
GSTM1GSTM1P09488P09488cellulardetoxificationofnitrogencompoundglutathionederivativebiosyntheticprocessglutathionemetabolicprocesshepoxilinbiosyntheticprocessnitrobenzenemetabolicprocessprostaglandinmetabolicprocessxenobioticcatabolicprocess
C-C chemokine receptor type 5
269
C-C motif chemokine 5
73
9.8
62
0.16
CCR5CCL5P51681P13501calciumiontransportcalcium-mediatedsignalingcellchemotaxiscellsurfacereceptorsignalingpathwaycell-cellsignalingcellulardefenseresponsecellularresponsetolipopolysaccharidechemotaxisdendriticcellchemotaxisGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseMAPKcascadepositiveregulationofcytosoliccalciumionconcentrationreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolsignalingactivationofphospholipaseDactivitycellularcalciumionhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetoviruschemokine-mediatedsignalingpathwayeosinophilchemotaxisexocytosisleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxismonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofinnateimmuneresponsepositiveregulationofmacrophagechemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftranslationalinitiationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofviralgenomereplicationproteinkinaseBsignalingregulationofchronicinflammatoryresponseregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetotoxicsubstanceresponsetovirus
Coagulation factor VII
187
Coagulation factor VII
322
9.8
73
0.14
FA7FA7P08709P08709activationofbloodcoagulationviaclottingcascadeanimalorganregenerationbloodcoagulationbloodcoagulationextrinsicpathwaybloodcoagulationfibrinclotformationbloodcoagulationintrinsicpathwaycircadianrhythmpositiveregulationofbloodcoagulationpositiveregulationofcellmigrationpositiveregulationofleukocytechemotaxispositiveregulationofplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofpositivechemotaxispositiveregulationofproteinkinaseBsignalingproteinprocessingproteolysisresponseto2378-tetrachlorodibenzodioxineresponsetoanticoagulantresponsetoastaxanthinresponsetocarbondioxideresponsetocholesterolresponsetoestradiolresponsetoestrogenresponsetogenisteinresponsetogrowthhormoneresponsetohypoxiaresponsetoThyroidstimulatinghormoneresponsetothyrotropin-releasinghormoneresponsetothyroxineresponsetovitaminKresponsetowoundingzymogenactivation
Repulsive guidance molecule B
163
Repulsive guidance molecule B
316
9.8
72
0.14
RGMBRGMBQ6NW40Q6NW40BMPsignalingpathwaycelladhesionpositiveregulationoftranscriptionDNA-templatedsignaltransduction
Glucocorticoid receptor
457
Glucocorticoid receptor
457
9.8
64
0.16
GCRGCRP04150P04150adrenalglanddevelopmentapoptoticprocesscellcyclecelldivisioncellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinorganizationchromosomesegregationglucocorticoidmetabolicprocessintracellularsteroidhormonereceptorsignalingpathwaymammaryglandductmorphogenesismaternalbehaviornegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedsignaltransduction
Beta-nerve growth factor
189
Beta-nerve growth factor
231
9.8
95
0.11
NGFNGFP01138P01138activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsmemorymodulationofchemicalsynaptictransmissionnegativeregulationofcellpopulationproliferationnegativeregulationofneuronapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwayneuronapoptoticprocessneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofcollateralsproutingpositiveregulationofDNAbindingpositiveregulationofgeneexpressionpositiveregulationofneurondifferentiationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofRasproteinsignaltransductionregulationofneurondifferentiationtransmembranereceptorproteintyrosinekinasesignalingpathway
Cathepsin B
105
Cathepsin B
187
9.8
67
0.15
CATBCATBP07688P07688cellularresponsetothyroidhormonestimuluscollagencatabolicprocessdecidualizationepithelialcelldifferentiationnegativeregulationofpeptidaseactivityproteolysisinvolvedinproteincatabolicprocessthyroidhormonegenerationviralentryintohostcell
Importin subunit beta-1
471
Zinc finger protein SNAI1
262
9.8
91
0.11
IMB1SNAI1Q14974O95863astralmicrotubuleorganizationestablishmentofmitoticspindlelocalizationestablishmentofproteinlocalizationmitoticchromosomemovementtowardsspindlepolemitoticmetaphaseplatecongressionmitoticspindleassemblyNLS-bearingproteinimportintonucleusproteinimportintonucleusRanproteinsignaltransductionribosomalproteinimportintonucleusRNAimportintonucleusaorticvalvemorphogenesiscartilagemorphogenesisepithelialcellmigrationepithelialtomesenchymaltransitionepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationhairfolliclemorphogenesisheterochromatinorganizationleft/rightpatternformationmesodermformationnegativeregulationofcelldifferentiationinvolvedinembryonicplacentadevelopmentnegativeregulationofDNAdamageresponsesignaltransductionbyp53classmediatornegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofvitaminDbiosyntheticprocessNotchsignalinginvolvedinheartdevelopmentosteoblastdifferentiationpositiveregulationofcellmigrationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationoftranscriptionDNA-templatedregulationofbicellulartightjunctionassemblyregulationoftranscriptionbyRNApolymeraseIIroofofmouthdevelopmenttrophoblastgiantcelldifferentiation
Prorelaxin H2
176
Prorelaxin H2
35
9.8
55
0.18
REL2REL2P04090P04090femalepregnancypositiveregulationofangiogenesispositiveregulationofgeneexpressionregulationofcatalyticactivity
Oxytocin-neurophysin 1
65
Oxytocin-neurophysin 1
110
9.8
101
0.1
NEU1NEU1P01175P01175positiveregulationofcold-inducedthermogenesisresponsetoestrogenresponsetoexternalbioticstimulusresponsetofoodresponsetomechanicalstimulus
C-C motif chemokine 17
33
C-C motif chemokine 17
57
9.8
62
0.16
CCL17CCL17Q92583Q92583antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisnegativeregulationofmyoblastdifferentiationneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
Pulmonary surfactant-associated protein B
331
Pulmonary surfactant-associated protein B
298
9.8
76
0.13
PSPBPSPBP50405P50405respiratorygaseousexchangebyrespiratorysystemsphingolipidmetabolicprocess
C-type lectin domain family 2 member D
91
C-type lectin domain family 2 member D
80
9.8
80
0.13
CLC2DCLC2DQ91V08Q91V08cellulardefenseresponsenegativeregulationofosteoclastdifferentiationprotectionfromnaturalkillercellmediatedcytotoxicity
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
957
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
957
9.8
73
0.14
PDE3APDE3AQ14432Q14432apoptoticsignalingpathwaycAMP-mediatedsignalingcellularresponsetocGMPcellularresponsetotransforminggrowthfactorbetastimuluscGMP-mediatedsignalingGprotein-coupledreceptorsignalingpathwaylipidmetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofcAMP-mediatedsignalingnegativeregulationofvascularpermeabilityoocytematurationpositiveregulationofoocytedevelopmentpositiveregulationofvascularpermeabilityregulationofmeioticnucleardivisionregulationofribonucleaseactivityresponsetoxenobioticstimulussignaltransduction
Casein kinase II subunit beta
140
Casein kinase II subunit beta
140
9.8
62
0.16
CSK2BCSK2BP67870P67870adiponectin-activatedsignalingpathwayendothelialtubemorphogenesisnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellpopulationproliferationpeptidyl-threoninephosphorylationpositiveregulationofactivinreceptorsignalingpathwaypositiveregulationofpathway-restrictedSMADproteinphosphorylationproteinphosphorylationprotein-containingcomplexassemblyregulationofDNAbindingregulationofproteinserine/threoninephosphataseactivitysignaltransductionWntsignalingpathway
Glutamate receptor ionotropic, delta-2
355
Glutamate receptor ionotropic, delta-2
83
9.8
78
0.13
GRID2GRID2Q63226Q63226cerebellargranulecelldifferentiationexcitatorypostsynapticpotentialexcitatorysynapseassemblyheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesmodulationofchemicalsynaptictransmissionpositiveregulationoflong-termsynapticdepressionpositiveregulationofsynapseassemblyprepulseinhibitionproteinlocalizationregulationofneuronapoptoticprocessregulationofneuronprojectiondevelopmentregulationofpostsynapticdensityassemblyregulationofpresynapseassemblysynaptictransmissionglutamatergic
Transforming growth factor beta-1 proprotein
389
Transforming growth factor beta-1 proprotein
355
9.8
84
0.12
TGFB1TGFB1P01137P01137aorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaycellmigrationcell-celljunctionorganizationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluschondrocytedifferentiationcommon-partnerSMADproteinphosphorylationconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingembryonicliverdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayheartdevelopmentheartvalvemorphogenesishematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphnodedevelopmentmacrophagederivedfoamcelldifferentiationMAPKcascademembraneproteinintracellulardomainproteolysisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofcytolysisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixdisassemblynegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofmacrophagecytokineproductionnegativeregulationofmiRNAmaturationnegativeregulationofmiRNAtranscriptionnegativeregulationofmiRNA-mediatedgenesilencingnegativeregulationofmyoblastdifferentiationnegativeregulationofproteinlocalizationtoplasmamembranenegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationoftranscriptionDNA-templatedneuraltubeclosureneuraltubedevelopmentossificationinvolvedinboneremodelingpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixassemblypositiveregulationoffibroblastmigrationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationofSMADproteinsignaltransductionpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularpermeabilityproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofbindingregulationofbloodvesselremodelingregulationofcellmigrationregulationofcellpopulationproliferationregulationofDNAbindingregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
Norrin
39
Norrin
93
9.8
73
0.14
NDPNDPQ00604Q00604decidualizationextracellularmatrix-cellsignalingnervoussystemdevelopmentNorrinsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoftranscriptionDNA-templatedretinavasculaturemorphogenesisincamera-typeeyevacuoleorganizationvisualperceptionWntsignalingpathway
Glucocorticoid receptor
473
Glucocorticoid receptor
457
9.8
69
0.15
GCRGCRP04150P04150adrenalglanddevelopmentapoptoticprocesscellcyclecelldivisioncellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinorganizationchromosomesegregationglucocorticoidmetabolicprocessintracellularsteroidhormonereceptorsignalingpathwaymammaryglandductmorphogenesismaternalbehaviornegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedsignaltransduction
Splicing factor 3B subunit 3
112
Splicing factor 3B subunit 5
41
9.8
89
0.11
SF3B3SF3B5Q15393Q9BWJ5histoneH3acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationmRNAsplicingviaspliceosomenegativeregulationofproteincatabolicprocesspositiveregulationoftranscriptionDNA-templatedregulationofDNArepairregulationofRNAsplicingRNAsplicingRNAsplicingviatransesterificationreactionsU2-typeprespliceosomeassembly
DNA polymerase subunit gamma-1
548
DNA polymerase subunit gamma-2, mitochondrial
399
9.8
60
0.17
DPOG1DPOG2P54098Q9UHN1base-excisionrepairgap-fillingDNAmetabolicprocessDNA-templatedDNAreplicationmitochondrialDNAreplicationDNArepairinuteroembryonicdevelopmentmitochondrionmorphogenesispositiveregulationofDNA-directedDNApolymeraseactivityrespiratoryelectrontransportchain
Growth/differentiation factor 5
500
Growth/differentiation factor 5
465
9.8
88
0.12
GDF5GDF5P43026P43026BMPsignalingpathwaycell-cellsignalingchondroblastdifferentiationchondrocytedifferentiationembryoniclimbmorphogenesisforelimbmorphogenesishindlimbmorphogenesismesenchymalcellapoptoticprocessnegativeregulationofchondrocytedifferentiationnegativeregulationofepithelialcellproliferationnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofneuronapoptoticprocessossificationinvolvedinboneremodelingpositiveregulationofBMPsignalingpathwaypositiveregulationofchondrocytedifferentiationpositiveregulationofneurondifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationregulationofmulticellularorganismgrowthregulationofSMADproteinsignaltransductionresponsetomechanicalstimulusSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Poly(A) RNA polymerase, mitochondrial
291
Poly(A) RNA polymerase, mitochondrial
291
9.8
76
0.13
PAPD1PAPD1Q9NVV4Q9NVV4histonemRNAcatabolicprocessmRNApolyadenylation"RNA3-endprocessing"
Tumor necrosis factor ligand superfamily member 13B
232
Tumor necrosis factor ligand superfamily member 13B
232
9.8
90
0.11
TN13BTN13BQ9Y275Q9Y275BcellcostimulationBcelldifferentiationBcellhomeostasisBcellproliferationgerminalcenterformationpositiveregulationofBcellproliferationpositiveregulationofgerminalcenterformationpositiveregulationofTcellproliferationsignaltransductionTcellcostimulationTcellproliferationtumornecrosisfactor-mediatedsignalingpathway
Glutamate receptor ionotropic, kainate 2
96
Glutamate receptor ionotropic, kainate 2
96
9.8
74
0.14
GRIK2GRIK2P42260P42260behavioralfearresponsecellularcalciumionhomeostasischemicalsynaptictransmissiondetectionofcoldstimulusinvolvedinthermoceptionexcitatorypostsynapticpotentialinhibitorypostsynapticpotentialmodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnegativeregulationofsynaptictransmissionglutamatergicneuronapoptoticprocessneuronalactionpotentialpositiveregulationofneuronapoptoticprocesspositiveregulationofsynaptictransmissionpresynapticmodulationofchemicalsynaptictransmissionreceptorclusteringregulationofJNKcascaderegulationoflong-termneuronalsynapticplasticityregulationofmembranepotentialregulationofshort-termneuronalsynapticplasticitysynaptictransmissionglutamatergic
Placenta growth factor
94
Placenta growth factor
77
9.8
64
0.16
PLGFPLGFP49763P49763animalorganregenerationcelldifferentiationcell-cellsignalingcellularresponsetohormonestimulusfemalepregnancyinductionofpositivechemotaxispositiveregulationofangiogenesispositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellproliferationpositiveregulationofmastcellchemotaxispositiveregulationofproteinphosphorylationresponsetohypoxiaresponsetoxenobioticstimulussignaltransductionsproutingangiogenesisvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathway
C-C motif chemokine 3
34
C-C motif chemokine 3
33
9.8
81
0.13
CCL3CCL3P10147P10147astrocytecellmigrationcalciumiontransportcalcium-mediatedsignalingcellactivationcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytoskeletonorganizationeosinophilchemotaxiseosinophildegranulationexocytosisGprotein-coupledreceptorsignalingpathwaygranulocytechemotaxisinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofosteoclastdifferentiationneutrophilchemotaxisosteoblastdifferentiationpositiveregulationofcalciumionimportpositiveregulationofcalciumiontransportpositiveregulationofcalcium-mediatedsignalingpositiveregulationofcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofmicroglialcellactivationpositiveregulationofmicroglialcellmigrationpositiveregulationofnaturalkillercellchemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofproteinkinaseBsignalingpositiveregulationoftumornecrosisfactorproductionproteinkinaseBsignalingregulationofbehaviorregulationofcellshaperegulationofsensoryperceptionofpainreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolresponsetotoxicsubstancesignalingTcellchemotaxis
Mitogen-activated protein kinase kinase kinase 20
22
Mitogen-activated protein kinase kinase kinase 20
285
9.8
69
0.15
M3K20M3K20Q9NYL2Q9NYL2cellcyclecelldeathcelldifferentiationcellularresponsetogammaradiationcytoskeletonorganizationDNAdamagecheckpointsignalingembryonicdigitmorphogenesisJNKcascadelimbdevelopmentp38MAPKcascadepeptidyl-serinephosphorylationpositiveregulationofapoptoticprocesspositiveregulationofmitoticDNAdamagecheckpointproteinphosphorylationstress-activatedMAPKcascade
Uridine phosphorylase
21
Uridine phosphorylase
224
9.8
56
0.18
A5PJH9A5PJH9A5PJH9A5PJH9nucleosidecatabolicprocessnucleotidecatabolicprocessUMPsalvage
Nuclear receptor subfamily 1 group I member 3
233
Nuclear receptor subfamily 1 group I member 3
221
9.8
71
0.14
NR1I3NR1I3O35627O35627celldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedosteoblastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templated
Insulin
31
Insulin
31
9.8
49
0.21
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
Transforming growth factor beta-1 proprotein
322
Transforming growth factor beta-1 proprotein
355
9.8
89
0.11
TGFB1TGFB1P01137P01137aorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaycellmigrationcell-celljunctionorganizationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluschondrocytedifferentiationcommon-partnerSMADproteinphosphorylationconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingembryonicliverdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayheartdevelopmentheartvalvemorphogenesishematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphnodedevelopmentmacrophagederivedfoamcelldifferentiationMAPKcascademembraneproteinintracellulardomainproteolysisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofcytolysisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixdisassemblynegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofmacrophagecytokineproductionnegativeregulationofmiRNAmaturationnegativeregulationofmiRNAtranscriptionnegativeregulationofmiRNA-mediatedgenesilencingnegativeregulationofmyoblastdifferentiationnegativeregulationofproteinlocalizationtoplasmamembranenegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationoftranscriptionDNA-templatedneuraltubeclosureneuraltubedevelopmentossificationinvolvedinboneremodelingpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixassemblypositiveregulationoffibroblastmigrationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationofSMADproteinsignaltransductionpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularpermeabilityproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofbindingregulationofbloodvesselremodelingregulationofcellmigrationregulationofcellpopulationproliferationregulationofDNAbindingregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
BRCA1-A complex subunit Abraxas 1
296
BRCA1-A complex subunit RAP80
298
9.8
83
0.12
ABRX1UIMC1Q8BPZ8Q5U5Q9attachmentofspindlemicrotubulestokinetochorechromatinorganizationdouble-strandbreakrepairhistoneH2AK63-linkeddeubiquitinationmitoticG2DNAdamagecheckpointsignalingmitoticG2/MtransitioncheckpointmitoticspindleassemblypositiveregulationofDNArepairproteinK63-linkeddeubiquitinationregulationofDNArepairresponsetoionizingradiationnegativeregulationoftranscriptionDNA-templated
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
271
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
271
9.8
72
0.14
BST1BST1Q10588Q10588humoralimmuneresponsepositiveregulationofBcellproliferationpositiveregulationofcellpopulationproliferationregulationofactincytoskeletonorganizationregulationofcalcium-mediatedsignalingregulationofcell-matrixadhesionregulationofcellularextravasationregulationofinflammatoryresponseregulationofintegrin-mediatedsignalingpathwayregulationofneutrophilchemotaxisregulationofpeptidyl-tyrosinephosphorylationregulationofsuperoxidemetabolicprocesssignaltransduction
Ferritin heavy chain
131
Ferritin heavy chain
131
9.8
76
0.13
FRIHFRIHP02794P02794cellularironionhomeostasisimmuneresponseintracellularsequesteringofironionironiontransportnegativeregulationofcellpopulationproliferationnegativeregulationoffibroblastproliferation
Fibrinogen beta chain
83
Fibrinogen beta chain
83
9.8
84
0.12
FIBBFIBBP02676P02676adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioninnateimmuneresponseplateletaggregationproteinpolymerization
Claudin-3
19
Claudin-3
19
9.8
82
0.12
CLD3CLD3Q9Z0G9Q9Z0G9actincytoskeletonreorganizationbicellulartightjunctionassemblycalcium-independentcell-celladhesionviaplasmamembranecell-adhesionmoleculescelladhesioncelljunctionmaintenanceepithelialcellmorphogenesisestablishmentofendothelialblood-brainbarriernegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationofgeneexpressionnegativeregulationofwoundhealingpositiveregulationofbicellulartightjunctionassemblypositiveregulationofcelljunctionassemblypositiveregulationofcellmigrationpositiveregulationofgeneexpressionpositiveregulationofmetallopeptidaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofwoundhealingregulationofcellmorphogenesisregulationofmembranepermeabilityregulationoftransepithelialtransportresponsetoethanolresponsetoGram-positivebacteriumresponsetohypoxia
Growth/differentiation factor 15
273
Growth/differentiation factor 15
211
9.8
81
0.13
GDF15GDF15Q99988Q99988BMPsignalingpathwaycell-cellsignalingglialcell-derivedneurotrophicfactorreceptorsignalingpathwaynegativeregulationofgrowthhormonereceptorsignalingpathwaynegativeregulationofmulticellularorganismgrowthpositiveregulationofMAPKcascadepositiveregulationofmyoblastfusionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinkinaseBsignalingreductionoffoodintakeinresponsetodietaryexcesssignaltransductionSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
368
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
368
9.8
73
0.14
I3LG77I3LG77I3LG77I3LG77dATPcatabolicprocessdefenseresponsetovirusdGTPcatabolicprocessDNAstrandresectioninvolvedinreplicationforkprocessingdouble-strandbreakrepairviahomologousrecombinationnegativeregulationoftypeIinterferon-mediatedsignalingpathwayproteinhomotetramerizationregulationofinnateimmuneresponsesomatichypermutationofimmunoglobulingenes
Angiopoietin-related protein 2
443
Angiopoietin-related protein 2
430
9.8
85
0.12
ANGL2ANGL2Q9UKU9Q9UKU9cell-cellsignaling
Glucocorticoid receptor
622
Glucocorticoid receptor
622
9.8
77
0.13
GCRGCRP04150P04150adrenalglanddevelopmentapoptoticprocesscellcyclecelldivisioncellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinorganizationchromosomesegregationglucocorticoidmetabolicprocessintracellularsteroidhormonereceptorsignalingpathwaymammaryglandductmorphogenesismaternalbehaviornegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedsignaltransduction
Dihydropyrimidinase-related protein 2
323
Dihydropyrimidinase-related protein 2
323
9.8
76
0.13
DPYL2DPYL2Q16555Q16555axonguidancebraindevelopmentcytoskeletonorganizationendocytosisnervoussystemdevelopmentnucleobase-containingcompoundmetabolicprocessregulationofaxonextensionregulationofneurondifferentiationsignaltransduction
Lysine-specific demethylase 2A
333
Lysine-specific demethylase 2A
477
9.8
69
0.15
KDM2AKDM2AP59997P59997chromatinorganizationcircadianregulationofgeneexpressiondouble-strandbreakrepairvianonhomologousendjoiningheartloopinghistoneH3-K36demethylationinuteroembryonicdevelopmentmulticellularorganismgrowthnegativeregulationofapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationoftranscriptionbycompetitivepromoterbindingneuraltubeclosureneuroepithelialcelldifferentiationneurondifferentiationpositiveregulationofgeneexpressionpositiveregulationofhistoneubiquitinationproteindemethylationregulationofcircadianrhythmregulationoftranscriptionbyRNApolymeraseII
Transforming growth factor beta-1 proprotein
293
Transforming growth factor beta-1 proprotein
355
9.8
81
0.13
TGFB1TGFB1P01137P01137aorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaycellmigrationcell-celljunctionorganizationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluschondrocytedifferentiationcommon-partnerSMADproteinphosphorylationconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingembryonicliverdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayheartdevelopmentheartvalvemorphogenesishematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphnodedevelopmentmacrophagederivedfoamcelldifferentiationMAPKcascademembraneproteinintracellulardomainproteolysisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofcytolysisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixdisassemblynegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofmacrophagecytokineproductionnegativeregulationofmiRNAmaturationnegativeregulationofmiRNAtranscriptionnegativeregulationofmiRNA-mediatedgenesilencingnegativeregulationofmyoblastdifferentiationnegativeregulationofproteinlocalizationtoplasmamembranenegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationoftranscriptionDNA-templatedneuraltubeclosureneuraltubedevelopmentossificationinvolvedinboneremodelingpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixassemblypositiveregulationoffibroblastmigrationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationofSMADproteinsignaltransductionpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularpermeabilityproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofbindingregulationofbloodvesselremodelingregulationofcellmigrationregulationofcellpopulationproliferationregulationofDNAbindingregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
Sorcin
57
Sorcin
75
9.8
75
0.14
SORCNSORCNP30626P30626actionpotentialcalciumiontransportcytoplasmicsequesteringoftranscriptionfactorheartdevelopmentintracellularsequesteringofironionmuscleorgandevelopmentnegativeregulationofcardiacmusclecontractionnegativeregulationofheartratenegativeregulationofryanodine-sensitivecalcium-releasechannelactivitynegativeregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofreleaseofsequesteredcalciumionintocytosolregulationofcalciumiontransportregulationofcardiacmusclecellcontractionregulationofcellcommunicationbyelectricalcouplingregulationofcellcommunicationbyelectricalcouplinginvolvedincardiacconductionregulationofheartcontractionregulationofhighvoltage-gatedcalciumchannelactivityregulationofrelaxationofmuscleregulationofreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumregulationofstriatedmusclecontractionsignaltransduction
Gremlin-2
101
Gremlin-2
101
9.1
89
0.12
GREM2GREM2O88273O88273animalorganmorphogenesiscytokine-mediatedsignalingpathwaydeterminationofdorsalidentityembryonicbodymorphogenesisnegativeregulationofBMPsignalingpathwayregulationofcytokineactivitysequesteringofBMPfromreceptorviaBMPbinding
S-adenosylmethionine synthase isoform type-1
34
S-adenosylmethionine synthase isoform type-1
68
9.1
87
0.13
METK1METK1Q00266Q00266methioninecatabolicprocessone-carbonmetabolicprocessproteinhomotetramerizationS-adenosylmethioninebiosyntheticprocess
Transforming growth factor beta-1 proprotein
223
Transforming growth factor beta-1 proprotein
223
9.1
63
0.17
TGFB1TGFB1P01137P01137aorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaycellmigrationcell-celljunctionorganizationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluschondrocytedifferentiationcommon-partnerSMADproteinphosphorylationconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingembryonicliverdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayheartdevelopmentheartvalvemorphogenesishematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphnodedevelopmentmacrophagederivedfoamcelldifferentiationMAPKcascademembraneproteinintracellulardomainproteolysisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofcytolysisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixdisassemblynegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofmacrophagecytokineproductionnegativeregulationofmiRNAmaturationnegativeregulationofmiRNAtranscriptionnegativeregulationofmiRNA-mediatedgenesilencingnegativeregulationofmyoblastdifferentiationnegativeregulationofproteinlocalizationtoplasmamembranenegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationoftranscriptionDNA-templatedneuraltubeclosureneuraltubedevelopmentossificationinvolvedinboneremodelingpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixassemblypositiveregulationoffibroblastmigrationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationofSMADproteinsignaltransductionpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularpermeabilityproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofbindingregulationofbloodvesselremodelingregulationofcellmigrationregulationofcellpopulationproliferationregulationofDNAbindingregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
Histone-lysine N-methyltransferase PRDM9
753
Histone-lysine N-methyltransferase PRDM9
557
9.2
46
0.24
PRDM9PRDM9Q9NQV7Q9NQV7chromatinorganizationdouble-strandbreakrepairinvolvedinmeioticrecombinationfemalegametegenerationhistoneH3-K36dimethylationhistoneH3-K36trimethylationhistoneH3-K4dimethylationhistoneH3-K4methylationhistoneH3-K4monomethylationhistoneH3-K4trimethylationhistoneH3-K9methylationhomologouschromosomepairingatmeiosismalegametegenerationmeioticgeneconversionnegativeregulationofapoptoticprocesspositiveregulationoffertilizationpositiveregulationofhistoneH3-K36trimethylationpositiveregulationofhistoneH3-K4trimethylationpositiveregulationofreciprocalmeioticrecombinationregulationofgeneexpressionregulationoftranscriptionDNA-templated
Hemoglobin subunit alpha
111
Hemoglobin subunit beta-A/B
112
9.2
77
0.14
HBAHBBP07405P07412cellularoxidantdetoxificationhydrogenperoxidecatabolicprocess
Adhesion G protein-coupled receptor L3
191
Adhesion G protein-coupled receptor L3
191
9.2
59
0.19
AGRL3AGRL3Q80TS3Q80TS3adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaybraindevelopmentcellsurfacereceptorsignalingpathwaycell-celladhesionviaplasma-membraneadhesionmoleculeslocomotioninvolvedinlocomotorybehaviorneuronmigrationpositiveregulationofsynapseassemblyresponsetococainesynapseassemblysynapseorganization
Complement C4-A
876
Complement C4-A
1583
9.1
70
0.16
CO4ACO4AP0C0L4P0C0L4complementactivationcomplementactivationclassicalpathwayinflammatoryresponseinnateimmuneresponsepositiveregulationofapoptoticcellclearancepositiveregulationofimmuneresponsepositiveregulationofopsonization
Ubiquitin carboxyl-terminal hydrolase 11
214
Ubiquitin carboxyl-terminal hydrolase 11
214
9.2
47
0.23
UBP11UBP11Q5D006Q5D006proteindeubiquitinationubiquitin-dependentproteincatabolicprocess
GTP-binding protein REM 1
213
GTP-binding protein REM 1
213
9.1
88
0.13
REM1REM1O75628O75628negativeregulationofhighvoltage-gatedcalciumchannelactivity
Tumor protein 63
244
Tumor protein 63
244
9.1
69
0.16
P63P63Q9H3D4Q9H3D4apoptoticprocesscellularresponsetoDNAdamagestimuluscellularsenescencechromatinremodelingcloacalseptationcranialskeletalsystemdevelopmentectodermandmesoderminteractionembryonicforelimbmorphogenesisembryonichindlimbmorphogenesisepidermalcelldivisionepithelialcelldevelopmentestablishmentofplanarpolarityestablishmentofskinbarrierfemalegenitaliamorphogenesishairfolliclemorphogenesisintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorkeratinocytedifferentiationkeratinocyteproliferationmulticellularorganismagingnegativeregulationofcellularsenescencenegativeregulationofintracellularestrogenreceptorsignalingpathwaynegativeregulationofkeratinocytedifferentiationnegativeregulationofmesodermdevelopmentnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneuronapoptoticprocessNotchsignalingpathwayodontogenesisofdentin-containingtoothpolarizedepithelialcelldifferentiationpositiveregulationofapoptoticsignalingpathwaypositiveregulationofcellcycleG1/SphasetransitionpositiveregulationoffibroblastapoptoticprocesspositiveregulationofkeratinocyteproliferationpositiveregulationofNotchsignalingpathwaypositiveregulationofosteoblastdifferentiationpositiveregulationofsomaticstemcellpopulationmaintenancepositiveregulationofstemcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpost-analtailmorphogenesisprostaticbudformationproteintetramerizationproximal/distalpatternformationregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessregulationofepidermalcelldivisionregulationoftranscriptionbyRNApolymeraseIIskeletalsystemdevelopmentskinmorphogenesisspermatogenesissquamousbasalepithelialstemcelldifferentiationinvolvedinprostateglandacinusdevelopmentstemcellproliferationsympatheticnervoussystemdevelopmenttranscriptionbyRNApolymeraseII
Ornithine decarboxylase
360
Ornithine decarboxylase
164
9.2
80
0.14
DCORDCORP11926P11926cellpopulationproliferationkidneydevelopmentpolyaminemetabolicprocesspositiveregulationofcellpopulationproliferationputrescinebiosyntheticprocessfromornithineregulationofproteincatabolicprocessresponsetovirus
DNA polymerase zeta catalytic subunit
1999
DNA polymerase zeta catalytic subunit
1999
9.2
71
0.15
REV3LREV3LO60673O60673DNA-templatedDNAreplicationdouble-strandbreakrepairviahomologousrecombinationerror-pronetranslesionsynthesis
Transforming growth factor beta-2 proprotein
379
Transforming growth factor beta-2 proprotein
380
9.2
78
0.14
TGFB2TGFB2P61812P61812activationofproteinkinaseactivityascendingaortamorphogenesisatrialseptummorphogenesisatrialseptumprimummorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwaycardiacepithelialtomesenchymaltransitioncardiacmusclecellproliferationcardiacrightventriclemorphogenesiscardioblastdifferentiationcelldeathcellmigrationcellmorphogenesiscell-celljunctionorganizationcollagenfibrilorganizationcranialskeletalsystemdevelopmentdopaminebiosyntheticprocessembryodevelopmentendinginbirthoregghatchingembryonicdigestivetractdevelopmentembryoniclimbmorphogenesisendocardialcushionfusionendocardialcushionmorphogenesisepithelialtomesenchymaltransitionextrinsicapoptoticsignalingpathwayeyedevelopmentgenerationofneuronsglialcellmigrationhairfollicledevelopmenthairfolliclemorphogenesisheartdevelopmentheartmorphogenesisheartvalvemorphogenesishemopoiesisinnereardevelopmentkidneydevelopmentmalegonaddevelopmentmembranousseptummorphogenesisnegativeregulationofalkalinephosphataseactivitynegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofepithelialcellproliferationnegativeregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationnegativeregulationofgeneexpressionnegativeregulationofmacrophagecytokineproductionnegativeregulationofRasproteinsignaltransductionneuralretinadevelopmentneuraltubeclosureneurondevelopmentneutrophilchemotaxisodontogenesisoutflowtractseptummorphogenesispathway-restrictedSMADproteinphosphorylationpharyngealarcharterymorphogenesispositiveregulationofcardioblastdifferentiationpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcellcyclepositiveregulationofcelldivisionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationpositiveregulationofheartcontractionpositiveregulationofimmuneresponsepositiveregulationofintegrinbiosyntheticprocesspositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationofNotchsignalingpathwaypositiveregulationofossificationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofstress-activatedMAPKcascadepositiveregulationoftimingofcatagenproteinphosphorylationpulmonaryvalvemorphogenesisregulationofapoptoticprocessinvolvedinoutflowtractmorphogenesisregulationofcellpopulationproliferationregulationoftimingofcatagenregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetoprogesteroneresponsetowoundingresponsetoxenobioticstimulussalivaryglandmorphogenesissecondarypalatedevelopmentskeletalsystemdevelopmentSMADproteinsignaltransductionsomaticstemcelldivisionsubstantiapropriaofcorneadevelopmenttransforminggrowthfactorbetareceptorsignalingpathwayuterinewallbreakdownuterusdevelopmentventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesiswoundhealing
Hemoglobin subunit alpha
105
Hemoglobin subunit delta
113
9.2
84
0.13
HBAHBDP69905P02042carbondioxidetransportcellularoxidantdetoxificationhydrogenperoxidecatabolicprocessnitricoxidetransportoxygentransportpositiveregulationofcelldeathresponsetohydrogenperoxide
Defensin beta 4A
31
Defensin beta 4A
38
9.2
87
0.13
DFB4ADFB4AO15263O15263antifungalinnateimmuneresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellchemotaxischemotaxisdefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponsekillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Hemoglobin subunit zeta
105
Hemoglobin subunit beta
113
9.2
86
0.13
HBAZHBBP02008P68871carbondioxidetransportcellularoxidantdetoxificationhydrogenperoxidecatabolicprocessoxygentransportpositiveregulationofcelldeathnitricoxidetransportplateletaggregationpositiveregulationofnitricoxidebiosyntheticprocessregulationofbloodpressurerenalabsorptionresponsetohydrogenperoxide
Transforming growth factor beta-2 proprotein
379
Transforming growth factor beta-2 proprotein
413
9.2
90
0.12
TGFB2TGFB2P61812P61812activationofproteinkinaseactivityascendingaortamorphogenesisatrialseptummorphogenesisatrialseptumprimummorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwaycardiacepithelialtomesenchymaltransitioncardiacmusclecellproliferationcardiacrightventriclemorphogenesiscardioblastdifferentiationcelldeathcellmigrationcellmorphogenesiscell-celljunctionorganizationcollagenfibrilorganizationcranialskeletalsystemdevelopmentdopaminebiosyntheticprocessembryodevelopmentendinginbirthoregghatchingembryonicdigestivetractdevelopmentembryoniclimbmorphogenesisendocardialcushionfusionendocardialcushionmorphogenesisepithelialtomesenchymaltransitionextrinsicapoptoticsignalingpathwayeyedevelopmentgenerationofneuronsglialcellmigrationhairfollicledevelopmenthairfolliclemorphogenesisheartdevelopmentheartmorphogenesisheartvalvemorphogenesishemopoiesisinnereardevelopmentkidneydevelopmentmalegonaddevelopmentmembranousseptummorphogenesisnegativeregulationofalkalinephosphataseactivitynegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofepithelialcellproliferationnegativeregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationnegativeregulationofgeneexpressionnegativeregulationofmacrophagecytokineproductionnegativeregulationofRasproteinsignaltransductionneuralretinadevelopmentneuraltubeclosureneurondevelopmentneutrophilchemotaxisodontogenesisoutflowtractseptummorphogenesispathway-restrictedSMADproteinphosphorylationpharyngealarcharterymorphogenesispositiveregulationofcardioblastdifferentiationpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcellcyclepositiveregulationofcelldivisionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationpositiveregulationofheartcontractionpositiveregulationofimmuneresponsepositiveregulationofintegrinbiosyntheticprocesspositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationofNotchsignalingpathwaypositiveregulationofossificationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofstress-activatedMAPKcascadepositiveregulationoftimingofcatagenproteinphosphorylationpulmonaryvalvemorphogenesisregulationofapoptoticprocessinvolvedinoutflowtractmorphogenesisregulationofcellpopulationproliferationregulationoftimingofcatagenregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetoprogesteroneresponsetowoundingresponsetoxenobioticstimulussalivaryglandmorphogenesissecondarypalatedevelopmentskeletalsystemdevelopmentSMADproteinsignaltransductionsomaticstemcelldivisionsubstantiapropriaofcorneadevelopmenttransforminggrowthfactorbetareceptorsignalingpathwayuterinewallbreakdownuterusdevelopmentventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesiswoundhealing
Glucocorticoid receptor
457
Glucocorticoid receptor
463
9.2
59
0.19
GCRGCRP04150P04150adrenalglanddevelopmentapoptoticprocesscellcyclecelldivisioncellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinorganizationchromosomesegregationglucocorticoidmetabolicprocessintracellularsteroidhormonereceptorsignalingpathwaymammaryglandductmorphogenesismaternalbehaviornegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedsignaltransduction
Fibrinogen alpha chain
68
Fibrinogen beta chain
95
9.1
65
0.17
FIBAFIBBP02671P02675adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncelladhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulus
Bone morphogenetic protein 6
477
Bone morphogenetic protein 6
512
9.1
86
0.13
BMP6BMP6P22004P22004BMPsignalingpathwaycartilagedevelopmentcellularironionhomeostasiscellularresponsetoBMPstimuluscellularresponsetoironioncellularresponsetomechanicalstimulusendochondralossificationeyedevelopmentimmuneresponseinflammatoryresponsekidneydevelopmentmalegenitaliadevelopmentmulticellularorganismalironionhomeostasisnegativeregulationofadherensjunctionorganizationnegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationoftranscriptionbyRNApolymeraseIIneurondifferentiationosteoblastdifferentiationpositiveregulationofaldosteronebiosyntheticprocesspositiveregulationofaldosteronesecretionpositiveregulationofbonemineralizationpositiveregulationofcellpopulationproliferationpositiveregulationofchondrocytedifferentiationpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofgeneexpressionpositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofneurondifferentiationpositiveregulationofosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinsecretionpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularpermeabilityresponsetoactivityresponsetoglucocorticoidresponsetomagnesiumionresponsetoretinoicacidskeletalsystemdevelopmentSMADproteinsignaltransductiontypeBpancreaticcelldevelopment
Protein Dok-7
45
Protein Dok-7
45
9.1
38
0.29
DOK7DOK7Q18PE0Q18PE0neuromuscularjunctiondevelopmentpositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivityproteinphosphorylationreceptorclustering
Hemoglobin subunit alpha
104
Hemoglobin subunit beta
112
9.1
84
0.13
HBAHBBP60529P60524cellularoxidantdetoxificationhydrogenperoxidecatabolicprocess
Transforming growth factor beta-3 proprotein
411
Transforming growth factor beta-3 proprotein
377
9.1
89
0.12
TGFB3TGFB3P10600P10600agingBMPsignalingpathwaycell-celljunctionorganizationdetectionofhypoxiadigestivetractdevelopmentembryonicneurocraniummorphogenesisfacemorphogenesisfemalepregnancyfrontalsuturemorphogenesisinuteroembryonicdevelopmentinnereardevelopmentlungalveolusdevelopmentmammaryglanddevelopmentnegativeregulationofcellpopulationproliferationnegativeregulationofmacrophagecytokineproductionnegativeregulationofneuronapoptoticprocessnegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofvascularassociatedsmoothmusclecellproliferationodontogenesisossificationinvolvedinboneremodelingpositiveregulationofapoptoticprocesspositiveregulationofbonemineralizationpositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationoffilopodiumassemblypositiveregulationofMAPKcascadepositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofSMADproteinsignaltransductionpositiveregulationofstressfiberassemblypositiveregulationoftightjunctiondisassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofcellpopulationproliferationresponsetoestrogenresponsetohypoxiaresponsetolaminarfluidshearstressresponsetoprogesteronesalivaryglandmorphogenesissecondarypalatedevelopmentSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwayuterinewallbreakdownwoundhealing
Epidermal growth factor receptor
231
Epidermal growth factor receptor
231
9.1
79
0.14
EGFREGFRP00533P00533activationofphospholipaseCactivitycelldifferentiationcellmorphogenesiscellsurfacereceptorsignalingpathwaycell-celladhesioncellularresponsetoaminoacidstimuluscellularresponsetocadmiumioncellularresponsetoepidermalgrowthfactorstimuluscellularresponsetoestradiolstimuluscellularresponsetoreactiveoxygenspeciescerebralcortexcellmigrationdigestivetractmorphogenesisembryonicplacentadevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialcellproliferationERBB2-EGFRsignalingpathwayeyeliddevelopmentincamera-typeeyehairfollicledevelopmentlearningormemorymorphogenesisofanepithelialfoldnegativeregulationofapoptoticprocessnegativeregulationofcardiocytedifferentiationnegativeregulationofepidermalgrowthfactorreceptorsignalingpathwaynegativeregulationofproteincatabolicprocessossificationpeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofDNArepairpositiveregulationofDNAreplicationpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofmiRNAmaturationpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinkinaseCactivitypositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteininsertionintomembraneregulationofERK1andERK2cascaderegulationofJNKcascaderegulationofnitric-oxidesynthaseactivityregulationofpeptidyl-tyrosinephosphorylationregulationofphosphatidylinositol3-kinasesignalingresponsetoUV-Asalivaryglandmorphogenesissignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
Brain-derived neurotrophic factor
239
Neurotrophin-3
205
9.1
85
0.13
BDNFNTF3P23560P20783axonguidancebrain-derivedneurotrophicfactorreceptorsignalingpathwaycollateralsproutingmemorymodulationofchemicalsynaptictransmissionnegativeregulationofapoptoticsignalingpathwaynegativeregulationofmyotubedifferentiationnegativeregulationofneuronapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwaynervoussystemdevelopmentneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofbrain-derivedneurotrophicfactorreceptorsignalingpathwaypositiveregulationofcollateralsproutingpositiveregulationofneuronprojectiondevelopmentpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofreceptorbindingpositiveregulationofsynapseassemblyregulationofneurondifferentiationregulationofproteinlocalizationtocellsurfacesynapseassemblytransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofGTPaseactivityactivationofproteinkinaseBactivitycell-cellsignalinginductionofpositivechemotaxisnegativeregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofactincytoskeletonreorganizationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofreceptorinternalizationregulationofapoptoticprocesssignaltransduction
Trypsin
33
Tissue factor pathway inhibitor
134
9.1
97
0.11
TRYPTFPI1P00761P10646digestionproteolysisbloodcoagulationcellularresponsetosteroidhormonestimulusnegativeregulationofbloodcoagulation
E3 ubiquitin/ISG15 ligase TRIM25
511
E3 ubiquitin/ISG15 ligase TRIM25
588
9.1
72
0.15
TRI25TRI25Q61510Q61510cellularresponsetoleukemiainhibitoryfactorinnateimmuneresponsenegativeregulationofviralentryintohostcellpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivityproteinmonoubiquitinationregulationofproteinlocalizationregulationofviralentryintohostcellresponsetoestrogenresponsetovitaminDsuppressionofviralreleasebyhostubiquitin-dependentERADpathwayubiquitin-dependentproteincatabolicprocessviralreleasefromhostcell
Parkinson disease protein 7
46
Parkinson disease protein 7
53
9.1
74
0.15
PARK7PARK7Q99497Q99497activationofproteinkinaseBactivityadultlocomotorybehaviorautophagycellulardetoxificationofaldehydecellulardetoxificationofmethylglyoxalcellularresponsetoglyoxalcellularresponsetohydrogenperoxidecellularresponsetooxidativestressdetectionofoxidativestressdetoxificationofcopperiondetoxificationofmercuryionDNArepairdopamineuptakeinvolvedinsynaptictransmissionglucosehomeostasisglutathionedeglycationglycolatebiosyntheticprocessglyoxalmetabolicprocessguaninedeglycationguaninedeglycationglyoxalremovalguaninedeglycationmethylglyoxalremovalhistonemodificationhydrogenperoxidemetabolicprocessinflammatoryresponseinsulinsecretionlactatebiosyntheticprocessmembranedepolarizationmembranehyperpolarizationmethylglyoxalcatabolicprocesstolactatemethylglyoxalmetabolicprocessmitochondrionorganizationnegativeregulationofapoptoticprocessnegativeregulationofcelldeathnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaynegativeregulationofdeath-inducingsignalingcomplexassemblynegativeregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofhydrogenperoxide-inducedneurondeathnegativeregulationofhydrogenperoxide-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofneuronapoptoticprocessnegativeregulationofneurondeathnegativeregulationofnitrosativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofoxidativestress-inducedcelldeathnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofproteinacetylationnegativeregulationofproteinbindingnegativeregulationofproteinexportfromnucleusnegativeregulationofproteinK48-linkeddeubiquitinationnegativeregulationofproteinkinaseactivitynegativeregulationofproteinphosphorylationnegativeregulationofproteinsumoylationnegativeregulationofproteinubiquitinationnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofTRAIL-activatedapoptoticsignalingpathwaynegativeregulationofubiquitin-proteintransferaseactivitynegativeregulationofubiquitin-specificproteaseactivitypeptidyl-argininedeglycationpeptidyl-cysteinedeglycationpeptidyl-lysinedeglycationpositiveregulationofacuteinflammatoryresponsetoantigenicstimuluspositiveregulationofandrogenreceptoractivitypositiveregulationofautophagyofmitochondrionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofdopaminebiosyntheticprocesspositiveregulationofgeneexpressionpositiveregulationofinterleukin-8productionpositiveregulationofL-dopabiosyntheticprocesspositiveregulationofL-dopadecarboxylaseactivitypositiveregulationofmitochondrialelectrontransportNADHtoubiquinonepositiveregulationofNAD(P)Hoxidaseactivitypositiveregulationofoxidativephosphorylationuncoupleractivitypositiveregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofprotein-containingcomplexassemblypositiveregulationofpyrroline-5-carboxylatereductaseactivitypositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofsuperoxidedismutaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftyrosine3-monooxygenaseactivityproteindeglycationglyoxalremovalproteindeglycationmethylglyoxalremovalproteindeglycosylationproteinstabilizationproteolysisRasproteinsignaltransductionregulationofandrogenreceptorsignalingpathwayregulationofhistoneacetylationregulationofhistoneubiquitinationregulationofinflammatoryresponseregulationofmitochondrialmembranepotentialregulationofneuronapoptoticprocessregulationofsupramolecularfiberorganizationresponsetooxidativestresssinglefertilization
Beta-secretase 2
393
Beta-secretase 2
393
9.1
76
0.14
BACE2BACE2Q9Y5Z0Q9Y5Z0amyloid-betametabolicprocessglucosehomeostasismembraneproteinectodomainproteolysisnegativeregulationofamyloidprecursorproteinbiosyntheticprocesspeptidehormoneprocessingproteolysis
Complement C4-A
876
Complement C4-A
1588
9.1
74
0.15
CO4ACO4AP0C0L4P0C0L4complementactivationcomplementactivationclassicalpathwayinflammatoryresponseinnateimmuneresponsepositiveregulationofapoptoticcellclearancepositiveregulationofimmuneresponsepositiveregulationofopsonization
Ubl carboxyl-terminal hydrolase 18
336
Ubl carboxyl-terminal hydrolase 18
336
4.2
73
0.33
UBP18UBP18Q9WTV6Q9WTV6negativeregulationoftypeIinterferon-mediatedsignalingpathwayproteindeubiquitinationregulationofinflammatoryresponseresponsetobacteriumresponsetostilbenoidubiquitin-dependentproteincatabolicprocess
Serine protease 1
64
Pancreatic trypsin inhibitor
73
10.0
84
0.12
TRY1BPT1P00760P00974digestionproteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Ferritin heavy chain
131
Ferritin heavy chain
131
10.0
76
0.13
FRIHFRIHP09528P09528immuneresponseintracellularsequesteringofironionironiontransportnegativeregulationofcellpopulationproliferationnegativeregulationoffibroblastproliferationnegativeregulationofnecroticcelldeath
Cellular tumor antigen p53
238
Cellular tumor antigen p53
182
10.0
77
0.13
P53P53P04637P04637autophagyBcelllineagecommitmentbonemarrowdevelopmentcardiacmusclecellapoptoticprocesscardiacseptummorphogenesiscellularresponsetoactinomycinDcellularresponsetoDNAdamagestimuluscellularresponsetogammaradiationcellularresponsetoglucosestarvationcellularresponsetohypoxiacellularresponsetoionizingradiationcellularresponsetoUVcellularresponsetoUV-CcellularresponsetoxenobioticstimuluscellularsenescencecerebellumdevelopmentchromatinassemblycircadianbehaviordeterminationofadultlifespanDNAdamageresponsesignaltransductionbyp53classmediatorDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestDNAdamageresponsesignaltransductionbyp53classmediatorresultingintranscriptionofp21classmediatordouble-strandbreakrepairembryonicorgandevelopmententrainmentofcircadianclockbyphotoperiodERoverloadresponsefibroblastproliferationgastrulationglialcellproliferationglucosecatabolicprocesstolactateviapyruvatehematopoieticprogenitorcelldifferentiationhematopoieticstemcelldifferentiationinuteroembryonicdevelopmentinterferon-gamma-mediatedsignalingpathwayintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwaybyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressintrinsicapoptoticsignalingpathwayinresponsetohypoxiamitochondrialDNArepairmitophagymitoticG1DNAdamagecheckpointsignalingmRNAtranscriptionmulticellularorganismgrowthnecroptoticprocessnegativeregulationofapoptoticprocessnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofDNAreplicationnegativeregulationoffibroblastproliferationnegativeregulationofG1toG0transitionnegativeregulationofglialcellproliferationnegativeregulationofglucosecatabolicprocesstolactateviapyruvatenegativeregulationofhelicaseactivitynegativeregulationofmiRNAmaturationnegativeregulationofmitophagynegativeregulationofneuroblastproliferationnegativeregulationofpentose-phosphateshuntnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofstemcellproliferationnegativeregulationoftelomeraseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayneuroblastproliferationneuronapoptoticprocessnucleotide-excisionrepairoligodendrocyteapoptoticprocessoxidativestress-inducedprematuresenescencepositiveregulationofapoptoticprocesspositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcellularsenescencepositiveregulationofexecutionphaseofapoptosispositiveregulationofgeneexpressionpositiveregulationofhistonedeacetylationpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofmitochondrialmembranepermeabilitypositiveregulationofneuronapoptoticprocesspositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofprogrammednecroticcelldeathpositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofreleaseofcytochromecfrommitochondriapositiveregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblypositiveregulationofthymocyteapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoendoplasmicreticulumstresspositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetostresspositiveregulationoftranscriptionDNA-templatedproteinimportintonucleusproteinlocalizationproteinstabilizationproteintetramerizationprotein-containingcomplexassemblyRasproteinsignaltransductionreactiveoxygenspeciesmetabolicprocessregulationofapoptoticprocessregulationofcellcycleregulationofcellcycleG2/MphasetransitionregulationofDNAdamageresponsesignaltransductionbyp53classmediatorregulationoffibroblastapoptoticprocessregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorregulationofmitochondrialmembranepermeabilityinvolvedinapoptoticprocessregulationoftissueremodelingregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoDNAdamageregulationoftranscriptionDNA-templatedreleaseofcytochromecfrommitochondriareplicativesenescenceresponsetoantibioticresponsetogammaradiationresponsetoischemiaresponsetosaltstressresponsetoX-rayrRNAtranscriptionsignaltransductionbyp53classmediatorsomitogenesisstemcellproliferationTcelldifferentiationinthymusTcelllineagecommitmentTcellproliferationinvolvedinimmuneresponsethymocyteapoptoticprocesstransforminggrowthfactorbetareceptorsignalingpathwaytumornecrosisfactor-mediatedsignalingpathwayviralprocess
C-C motif chemokine 1
33
C-C motif chemokine 1
73
10.0
75
0.13
CCL1CCL1P22362P22362antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiseosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-17productionpositiveregulationofmonocytechemotaxissignaltransductionviralprocess
3-hydroxy-3-methylglutaryl-coenzyme A reductase
561
3-hydroxy-3-methylglutaryl-coenzyme A reductase
527
10.0
70
0.14
HMDHHMDHP04035P04035cholesterolbiosyntheticprocesscoenzymeAmetabolicprocessisoprenoidbiosyntheticprocessnegativeregulationofamyloid-betaclearancenegativeregulationofMAPkinaseactivitynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionsterolbiosyntheticprocessvisuallearning
Artemin
187
Artemin
188
10.0
71
0.14
ARTNARTNQ5T4W7Q5T4W7axonguidanceinductionofpositivechemotaxislymphocytemigrationintolymphoidorgansneuroblastproliferationperipheralnervoussystemdevelopment"Peyerspatchmorphogenesis"signaltransduction
Dihydropyrimidine dehydrogenase [NADP(+)]
956
Dihydropyrimidine dehydrogenase [NADP(+)]
79
10.0
89
0.11
DPYDDPYDQ28943Q28943beta-alaninebiosyntheticprocessthymidinecatabolicprocessthyminecatabolicprocessuracilcatabolicprocess
Transforming growth factor beta-1 proprotein
355
Transforming growth factor beta-1 proprotein
326
10.0
86
0.12
TGFB1TGFB1P01137P01137aorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaycellmigrationcell-celljunctionorganizationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluschondrocytedifferentiationcommon-partnerSMADproteinphosphorylationconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingembryonicliverdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayheartdevelopmentheartvalvemorphogenesishematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphnodedevelopmentmacrophagederivedfoamcelldifferentiationMAPKcascademembraneproteinintracellulardomainproteolysisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofcytolysisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixdisassemblynegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofmacrophagecytokineproductionnegativeregulationofmiRNAmaturationnegativeregulationofmiRNAtranscriptionnegativeregulationofmiRNA-mediatedgenesilencingnegativeregulationofmyoblastdifferentiationnegativeregulationofproteinlocalizationtoplasmamembranenegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationoftranscriptionDNA-templatedneuraltubeclosureneuraltubedevelopmentossificationinvolvedinboneremodelingpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixassemblypositiveregulationoffibroblastmigrationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationofSMADproteinsignaltransductionpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularpermeabilityproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofbindingregulationofbloodvesselremodelingregulationofcellmigrationregulationofcellpopulationproliferationregulationofDNAbindingregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
Malate dehydrogenase, cytoplasmic
251
Malate dehydrogenase, cytoplasmic
60
10.0
80
0.13
MDHCMDHCP11708P11708malatemetabolicprocessNADHmetabolicprocessoxaloacetatemetabolicprocesstricarboxylicacidcycle
4-trimethylaminobutyraldehyde dehydrogenase
289
4-trimethylaminobutyraldehyde dehydrogenase
484
10.0
95
0.11
AL9A1AL9A1P49189P49189carnitinebiosyntheticprocesscellularaldehydemetabolicprocesshormonemetabolicprocessneurotransmitterbiosyntheticprocessproteinhomotetramerization
Protein cereblon
394
Protein cereblon
397
10.0
70
0.14
CRBNCRBNQ8C7D2Q8C7D2locomotoryexplorationbehaviornegativeregulationofiontransmembranetransportnegativeregulationoflargeconductancecalcium-activatedpotassiumchannelactivitynegativeregulationofprotein-containingcomplexassemblypositiveregulationofprotein-containingcomplexassemblyproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitination
Glycoprotein hormones alpha chain
83
Follitropin subunit beta
105
10.0
79
0.13
GLHAFSHBP01215P01225follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationfemalegametegenerationfemalepregnancypositiveregulationofboneresorptionpositiveregulationofgeneexpressionprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationSertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Cathepsin B
105
Cathepsin B
187
10.0
68
0.15
CATBCATBP07858P07858cellularresponsetothyroidhormonestimuluscollagencatabolicprocessdecidualizationepithelialcelldifferentiationnegativeregulationofpeptidaseactivityproteolysisproteolysisinvolvedinproteincatabolicprocessregulationofapoptoticprocessthyroidhormonegenerationviralentryintohostcell
PHD finger protein 6
283
PHD finger protein 6
283
10.0
68
0.15
PHF6PHF6Q8IWS0Q8IWS0blastocysthatchingnegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Anionic trypsin-2
64
Pancreatic trypsin inhibitor
73
10.0
82
0.12
TRY2BPT1P00763P00974collagencatabolicprocessdigestionproteolysisresponsetonutrientnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Defensin beta 4A
53
Defensin beta 4A
31
10.0
90
0.11
DFB4ADFB4AO15263O15263antifungalinnateimmuneresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellchemotaxischemotaxisdefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponsekillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Glucocorticoid receptor
476
Glucocorticoid receptor
476
9.9
63
0.16
GCRGCRP06536P06536adrenalglanddevelopmentagingandrogenmetabolicprocessbraindevelopmentcellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetomagnesiumioncellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinremodelingcircadianrhythmepigeneticmaintenanceofchromatinintranscription-competentconformationfemalepregnancyglucocorticoidmetabolicprocessglucocorticoidreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaylungdevelopmentmammaryglandductmorphogenesismaternalbehaviormuscleatrophynegativeregulationofapoptoticprocessnegativeregulationofsynapticplasticitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationofvascularpermeabilitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofdendriticspinedevelopmentpositiveregulationofglucocorticoidreceptorsignalingpathwaypositiveregulationofglutamatesecretionpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprotein-containingcomplexassemblyregulationofcellpopulationproliferationregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationofglucosemetabolicprocessregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetoactivityresponsetoarsenic-containingsubstanceresponsetocalciumionresponsetocorticosteroneresponsetodexamethasoneresponsetoelectricalstimulusresponsetoinactivityresponsetoinsulinresponsetomercuryionresponsetoradiation
Isovaleryl-CoA dehydrogenase, mitochondrial
370
Isovaleryl-CoA dehydrogenase, mitochondrial
339
9.9
89
0.11
IVDIVDP26440P26440branched-chainaminoacidcatabolicprocessfattyacidbeta-oxidationusingacyl-CoAdehydrogenaseleucinecatabolicprocess
Glucocorticoid receptor
473
Glucocorticoid receptor
457
9.9
71
0.14
GCRGCRP79269P79269cellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluschromatinorganizationpositiveregulationoftranscriptionbyRNApolymeraseII
Epidermal growth factor receptor
219
Epidermal growth factor receptor
231
9.9
81
0.12
EGFREGFRP00533P00533activationofphospholipaseCactivitycelldifferentiationcellmorphogenesiscellsurfacereceptorsignalingpathwaycell-celladhesioncellularresponsetoaminoacidstimuluscellularresponsetocadmiumioncellularresponsetoepidermalgrowthfactorstimuluscellularresponsetoestradiolstimuluscellularresponsetoreactiveoxygenspeciescerebralcortexcellmigrationdigestivetractmorphogenesisembryonicplacentadevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialcellproliferationERBB2-EGFRsignalingpathwayeyeliddevelopmentincamera-typeeyehairfollicledevelopmentlearningormemorymorphogenesisofanepithelialfoldnegativeregulationofapoptoticprocessnegativeregulationofcardiocytedifferentiationnegativeregulationofepidermalgrowthfactorreceptorsignalingpathwaynegativeregulationofproteincatabolicprocessossificationpeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofDNArepairpositiveregulationofDNAreplicationpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofmiRNAmaturationpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinkinaseCactivitypositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteininsertionintomembraneregulationofERK1andERK2cascaderegulationofJNKcascaderegulationofnitric-oxidesynthaseactivityregulationofpeptidyl-tyrosinephosphorylationregulationofphosphatidylinositol3-kinasesignalingresponsetoUV-Asalivaryglandmorphogenesissignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
Dihydropyrimidine dehydrogenase [NADP(+)]
82
Dihydropyrimidine dehydrogenase [NADP(+)]
953
10.0
84
0.12
DPYDDPYDQ28943Q28943beta-alaninebiosyntheticprocessthymidinecatabolicprocessthyminecatabolicprocessuracilcatabolicprocess
Prosaposin
357
Prosaposin
318
10.0
77
0.13
SAPSAPP07602P07602adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayepithelialcelldifferentiationinvolvedinprostateglanddevelopmentgangliosideGM1transporttomembranelysosomaltransportpositiveregulationofbeta-galactosidaseactivityprostateglandgrowthregulationofautophagyregulationoflipidmetabolicprocesssphingolipidmetabolicprocess
Neurogenic locus notch homolog protein 3
1475
Neurogenic locus notch homolog protein 3
1488
10.0
90
0.11
NOTC3NOTC3Q9UM47Q9UM47arterymorphogenesisaxonguidanceforebraindevelopmentglomerularcapillaryformationnegativeregulationofneurondifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIneuroblastdifferentiationneuronfatecommitmentNotchsignalingpathwaypositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseII
Cytochrome c
18
Cytochrome c
18
10.0
56
0.18
CYCCYCP00004P00004apoptoticprocesscytochromec-hemelinkagemitochondrialelectrontransportcytochromectooxygenmitochondrialelectrontransportubiquinoltocytochromecpositiveregulationofapoptoticprocesspositiveregulationofcysteine-typeendopeptidaseactivitypositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocess
ADP-ribosylation factor 1
159
ADP-ribosylation factor 1
159
10.0
69
0.15
ARF1ARF1P84077P84077cellularcopperionhomeostasiscellularresponsetovirusdendriticspineorganizationintracellularproteintransportlong-termsynapticdepressionmitoticcleavagefurrowingressionregulationofArp2/3complex-mediatedactinnucleationregulationofreceptorinternalizationvesicle-mediatedtransport
Resistin-like beta
76
Resistin-like beta
76
10.0
85
0.12
RETNBRETNBQ99P86Q99P86responsetobacterium
C-C motif chemokine 14
36
C-C motif chemokine 14
35
10.0
76
0.13
CCL14CCL14Q16627Q16627cellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwayGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
165
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
157
10.0
67
0.15
PDE1BPDE1BQ01064Q01064cellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimuluscellularresponsetomacrophagecolony-stimulatingfactorstimuluslocomotorybehaviormonocytedifferentiationregulationofdopaminemetabolicprocessregulationofneurotransmitterlevelsresponsetoamphetamineserotoninmetabolicprocesssignaltransductionvisuallearning
Checkpoint protein HUS1
200
Cell cycle checkpoint protein RAD1
92
10.0
76
0.13
HUS1RAD1O60921O60671cellularresponsetoDNAdamagestimuluscellularresponsetoionizingradiationDNAdamagecheckpointsignalingDNArepairdouble-strandbreakrepairviahomologousrecombinationembryodevelopmentendinginbirthoregghatchingmeioticDNAintegritycheckpointsignalingmitoticDNAreplicationcheckpointsignalingmitoticintra-SDNAdamagecheckpointsignalingnucleotide-excisionrepairproteinphosphorylationregulationofproteinphosphorylationresponsetoUVtelomeremaintenancemeioticrecombinationcheckpointsignalingsubstantianigradevelopment
Tumor protein p73
262
Tumor protein p73
194
10.0
63
0.16
P73P73O15350O15350cellcyclecellularresponsetoDNAdamagestimulusintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorkidneydevelopmentmismatchrepairnegativeregulationofcardiacmusclecellproliferationnegativeregulationofcellpopulationproliferationnegativeregulationofneurondifferentiationpositiveregulationofapoptoticprocesspositiveregulationoflungciliatedcelldifferentiationpositiveregulationofMAPKcascadepositiveregulationofoligodendrocytedifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedproteintetramerizationregulationofcellcycleregulationofgeneexpressionregulationofmitoticcellcycleregulationoftranscriptionbyRNApolymeraseIIresponsetoorganonitrogencompoundresponsetoxenobioticstimulus
Laminin subunit beta-1
1785
Laminin subunit beta-1
1785
10.0
64
0.16
LAMB1LAMB1P07942P07942animalorganmorphogenesisbasementmembraneassemblycelladhesioncellmigrationendodermalcelldifferentiationneuronprojectiondevelopmentneuronal-glialinteractioninvolvedincerebralcortexradialgliaguidedmigrationodontogenesispositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofepithelialcellproliferationpositiveregulationofintegrin-mediatedsignalingpathwaypositiveregulationofmusclecelldifferentiationregulationofbasementmembraneorganizationsubstrateadhesion-dependentcellspreadingtissuedevelopment
Trimethylguanosine synthase
745
Trimethylguanosine synthase
745
10.0
81
0.12
TGS1TGS1Q96RS0Q96RS07-methylguanosinecaphypermethylation7-methylguanosineRNAcappingribonucleoproteincomplexbiogenesisspliceosomalsnRNPassembly
Glutamate receptor ionotropic, kainate 2
96
Glutamate receptor ionotropic, kainate 2
347
10.0
71
0.14
GRIK2GRIK2P42260P42260behavioralfearresponsecellularcalciumionhomeostasischemicalsynaptictransmissiondetectionofcoldstimulusinvolvedinthermoceptionexcitatorypostsynapticpotentialinhibitorypostsynapticpotentialmodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnegativeregulationofsynaptictransmissionglutamatergicneuronapoptoticprocessneuronalactionpotentialpositiveregulationofneuronapoptoticprocesspositiveregulationofsynaptictransmissionpresynapticmodulationofchemicalsynaptictransmissionreceptorclusteringregulationofJNKcascaderegulationoflong-termneuronalsynapticplasticityregulationofmembranepotentialregulationofshort-termneuronalsynapticplasticitysynaptictransmissionglutamatergic
Serine protease 1
64
Pancreatic trypsin inhibitor
73
10.0
84
0.12
TRY1BPT1P07477P00974digestionextracellularmatrixdisassemblyproteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Vasopressin-neurophysin 2-copeptin
65
Vasopressin-neurophysin 2-copeptin
110
10.0
102
0.1
NEU2NEU2P01180P01180vasoconstriction
Caspase-7
70
Caspase-7
246
10.0
72
0.14
CASP7CASP7P55210P55210apoptoticprocesscellularresponsetostaurosporineexecutionphaseofapoptosisextrinsicapoptoticsignalingpathwayfibroblastapoptoticprocessheartdevelopmentinflammatoryresponseintrinsicapoptoticsignalingpathwayneuronapoptoticprocesspositiveregulationofapoptoticprocessproteinprocessingproteolysisresponsetoUV
Mast/stem cell growth factor receptor Kit
673
Mast/stem cell growth factor receptor Kit
674
9.9
70
0.14
KITKITP10721P10721actincytoskeletonreorganizationBcelldifferentiationcellchemotaxiscellularresponsetothyroidhormonestimuluscytokine-mediatedsignalingpathwaydetectionofmechanicalstimulusinvolvedinsensoryperceptionofsounddigestivetractdevelopmentectopicgermcellprogrammedcelldeathembryonichemopoiesisepithelialcellproliferationerythrocytedifferentiationerythropoietin-mediatedsignalingpathwayFcreceptorsignalingpathwaygermcellmigrationglycosphingolipidmetabolicprocesshematopoieticprogenitorcelldifferentiationhematopoieticstemcellmigrationhemopoiesisimmatureBcelldifferentiationinflammatoryresponseintracellularsignaltransductionKitsignalingpathwaylamellipodiumassemblylymphoidprogenitorcelldifferentiationmalegonaddevelopmentmastcellchemotaxismastcelldegranulationmastcelldifferentiationmastcellproliferationmegakaryocytedevelopmentmelanocyteadhesionmelanocytedifferentiationmelanocytemigrationmyeloidprogenitorcelldifferentiationnegativeregulationofdevelopmentalprocessnegativeregulationofprogrammedcelldeathnegativeregulationofreproductiveprocessovarianfollicledevelopmentpigmentationpositiveregulationofcellmigrationpositiveregulationofcolonsmoothmusclecontractionpositiveregulationofdendriticcellcytokineproductionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofkinaseactivitypositiveregulationoflong-termneuronalsynapticplasticitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmastcellcytokineproductionpositiveregulationofmastcellproliferationpositiveregulationofNotchsignalingpathwaypositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphospholipaseCactivitypositiveregulationofpseudopodiumassemblypositiveregulationofpyloricantrumsmoothmusclecontractionpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmallintestinesmoothmusclecontractionpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecelldifferentiationproteinautophosphorylationregulationofbileacidmetabolicprocessregulationofcellpopulationproliferationregulationofcellshaperesponsetocadmiumionsignaltransductionsomaticstemcelldivisionsomaticstemcellpopulationmaintenancespermatiddevelopmentspermatogenesisstemcelldifferentiationstemcellpopulationmaintenanceTcelldifferentiationtonguedevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathwayvisuallearning
Cytidine deaminase
99
Cytidine deaminase
99
10.0
92
0.11
CDDCDDP56389P56389cellularresponsetoexternalbioticstimulusCMPcatabolicprocesscytidinedeaminationdCMPcatabolicprocessnegativeregulationofcellgrowthnegativeregulationofnucleotidemetabolicprocessresponsetocycloheximideUMPsalvage
Bone morphogenetic protein 2
360
Bone morphogenetic protein 2
395
10.0
86
0.12
BMP2BMP2P12643P12643ameloblastdifferentiationanimalorganmorphogenesisaorticvalvedevelopmentastrocytedifferentiationatrioventricularcanalmorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwayBMPsignalingpathwayinvolvedinheartdevelopmentBMPsignalingpathwayinvolvedinheartinductionbonemineralizationbonemineralizationinvolvedinbonematurationbranchinginvolvedinuretericbudmorphogenesiscardiacatriumformationcardiacepithelialtomesenchymaltransitioncardiacjellydevelopmentcardiacmusclecelldifferentiationcardiacmuscletissuemorphogenesiscardiocytedifferentiationcellfatecommitmentcell-cellsignalingcellularresponsetoBMPstimuluscellularresponsetoorganiccycliccompoundchondrocytedifferentiationcorticotropinhormonesecretingcelldifferentiationembryonichearttubeanterior/posteriorpatternspecificationendocardialcushionformationendocardialcushionmorphogenesisepithelialtomesenchymaltransitionheartdevelopmentinuteroembryonicdevelopmentinflammatoryresponseinnereardevelopmentmesenchymalcelldifferentiationmesenchymalcellproliferationinvolvedinuretericbuddevelopmentmesenchymedevelopmentnegativeregulationofaldosteronebiosyntheticprocessnegativeregulationofcalcium-independentcell-celladhesionnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcardiacmusclecelldifferentiationnegativeregulationofcellcyclenegativeregulationofcellpopulationproliferationnegativeregulationofcortisolbiosyntheticprocessnegativeregulationofgeneexpressionnegativeregulationofinsulin-likegrowthfactorreceptorsignalingpathwaynegativeregulationofMAPkinaseactivitynegativeregulationofsmoothmusclecellproliferationnegativeregulationofsteroidbiosyntheticprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofWntsignalingpathwayinvolvedinheartdevelopmentNotchsignalingpathwayodontogenesisofdentin-containingtoothosteoblastdifferentiationpathway-restrictedSMADproteinphosphorylationpericardiumdevelopmentpositiveregulationofapoptoticprocesspositiveregulationofastrocytedifferentiationpositiveregulationofbonemineralizationpositiveregulationofcartilagedevelopmentpositiveregulationofcellmigrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcelldifferentiationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixconstituentsecretionpositiveregulationoffatcelldifferentiationpositiveregulationofgeneexpressionpositiveregulationofMAPKcascadepositiveregulationofmiRNAtranscriptionpositiveregulationofneurondifferentiationpositiveregulationofodontogenesispositiveregulationofossificationpositiveregulationofosteoblastdifferentiationpositiveregulationofosteoblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofperoxisomeproliferatoractivatedreceptorsignalingpathwaypositiveregulationofphosphataseactivitypositiveregulationofproteinbindingpositiveregulationofproteinphosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimuluspositiveregulationoftranscriptionDNA-templatedpositiveregulationofWntsignalingpathwaypositiveregulationofWntsignalingpathwaybyBMPsignalingpathwayproteindestabilizationproteinphosphorylationproteoglycanmetabolicprocessregulationofodontogenesisofdentin-containingtoothregulationoftranscriptionDNA-templatedresponsetobacteriumresponsetohypoxiaskeletalsystemdevelopmentSMADproteinsignaltransductiontelencephalondevelopmenttelencephalonregionalizationthyroid-stimulatinghormone-secretingcelldifferentiationtranscriptionbyRNApolymeraseIIWntsignalingpathway
Centrosomal protein of 152 kDa
1279
Centrosomal protein of 152 kDa
1279
9.9
40
0.25
CE152CE152O94986O94986cellprojectionorganizationcentriolereplicationcentrosomeduplicationdenovocentrioleassemblyinvolvedinmulti-ciliatedepithelialcelldifferentiation
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
107
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
107
9.9
97
0.1
GPTGPTQ9H3H5Q9H3H5dolicholmetabolicprocessdolichol-linkedoligosaccharidebiosyntheticprocessproteinN-linkedglycosylationUDP-N-acetylglucosaminemetabolicprocess
Mitotic spindle assembly checkpoint protein MAD2B
70
DNA polymerase zeta catalytic subunit
1997
10.0
60
0.17
MD2L2REV3LQ9D752O60673actinfilamentorganizationcellcyclecelldivisionDNAdamageresponsesignaltransductionresultingintranscriptiondouble-strandbreakrepairerror-pronetranslesionsynthesisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofdouble-strandbreakrepairviahomologousrecombinationnegativeregulationofepithelialtomesenchymaltransitionnegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbycompetitivepromoterbindingnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionregulatoryregionDNAbindingnegativeregulationofubiquitinproteinligaseactivitypositiveregulationofdouble-strandbreakrepairvianonhomologousendjoiningpositiveregulationofisotypeswitchingpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationoftranscriptionDNA-templatedregulationofcellgrowthsomaticdiversificationofimmunoglobulinsinvolvedinimmuneresponsetelomeremaintenanceinresponsetoDNAdamageDNA-templatedDNAreplicationdouble-strandbreakrepairviahomologousrecombination
Glucocorticoid receptor
482
Glucocorticoid receptor
495
10.0
69
0.15
GCRGCRP06536P06536adrenalglanddevelopmentagingandrogenmetabolicprocessbraindevelopmentcellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetomagnesiumioncellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinremodelingcircadianrhythmepigeneticmaintenanceofchromatinintranscription-competentconformationfemalepregnancyglucocorticoidmetabolicprocessglucocorticoidreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaylungdevelopmentmammaryglandductmorphogenesismaternalbehaviormuscleatrophynegativeregulationofapoptoticprocessnegativeregulationofsynapticplasticitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationofvascularpermeabilitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofdendriticspinedevelopmentpositiveregulationofglucocorticoidreceptorsignalingpathwaypositiveregulationofglutamatesecretionpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprotein-containingcomplexassemblyregulationofcellpopulationproliferationregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationofglucosemetabolicprocessregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetoactivityresponsetoarsenic-containingsubstanceresponsetocalciumionresponsetocorticosteroneresponsetodexamethasoneresponsetoelectricalstimulusresponsetoinactivityresponsetoinsulinresponsetomercuryionresponsetoradiation
Coatomer subunit epsilon
34
Coatomer subunit alpha
975
10.0
72
0.14
COPECOPAQ28104Q27954endoplasmicreticulumtoGolgivesicle-mediatedtransportintra-Golgivesicle-mediatedtransportproteinlocalizationtoaxonproteintransportretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulumintracellularproteintransport
Biglycan
70
Biglycan
188
10.0
69
0.15
PGS1PGS1P21809P21809articularcartilagedevelopmentbonedevelopmentpeptidecross-linkingviachondroitin4-sulfateglycosaminoglycan
Microtubule-associated serine/threonine-protein kinase 1
1015
Microtubule-associated serine/threonine-protein kinase 1
1015
10.0
70
0.14
MAST1MAST1Q9Y2H9Q9Y2H9braindevelopmentcytoskeletonorganizationintracellularsignaltransductionpeptidyl-serinephosphorylationproteinphosphorylation
NAD-dependent protein deacetylase sirtuin-2
200
NAD-dependent protein deacetylase sirtuin-2
200
9.9
46
0.22
SIR2SIR2Q8IXJ6Q8IXJ6autophagycelldivisioncellularlipidcatabolicprocesscellularresponsetocaloricrestrictioncellularresponsetoepinephrinestimuluscellularresponsetohepatocytegrowthfactorstimuluscellularresponsetohypoxiacellularresponsetomoleculeofbacterialorigincellularresponsetooxidativestresshepatocytegrowthfactorreceptorsignalingpathwayheterochromatinassemblyhistonedeacetylationhistoneH3deacetylationhistoneH4deacetylationinnateimmuneresponsemeioticcellcyclemitoticnuclearmembranereassemblymyelinationinperipheralnervoussystemnegativeregulationofautophagynegativeregulationofcellpopulationproliferationnegativeregulationofdefenseresponsetobacteriumnegativeregulationoffatcelldifferentiationnegativeregulationofNLRP3inflammasomecomplexassemblynegativeregulationofoligodendrocyteprogenitorproliferationnegativeregulationofpeptidyl-threoninephosphorylationnegativeregulationofproteincatabolicprocessnegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofstriatedmuscletissuedevelopmentnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxianegativeregulationoftranscriptionDNA-templatedNLRP3inflammasomecomplexassemblypeptidyl-lysinedeacetylationphosphatidylinositol3-kinasesignalingpositiveregulationofattachmentofspindlemicrotubulestokinetochorepositiveregulationofcelldivisionpositiveregulationofDNAbindingpositiveregulationofexecutionphaseofapoptosispositiveregulationofmeioticnucleardivisionpositiveregulationofoocytematurationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessinvolvedincellularresponsetohypoxiapositiveregulationoftranscriptionbyRNApolymeraseIIproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinADP-ribosylationproteindeacetylationproteinkinaseBsignalingrDNAheterochromatinassemblyregulationofcellcycleregulationofexitfrommitosisregulationofmyelinationregulationofphosphorylationresponsetoredoxstatesubstantianigradevelopmentsubtelomericheterochromatinassemblytubulindeacetylation
Growth/differentiation factor 15
273
Growth/differentiation factor 15
307
9.9
82
0.12
GDF15GDF15Q99988Q99988BMPsignalingpathwaycell-cellsignalingglialcell-derivedneurotrophicfactorreceptorsignalingpathwaynegativeregulationofgrowthhormonereceptorsignalingpathwaynegativeregulationofmulticellularorganismgrowthpositiveregulationofMAPKcascadepositiveregulationofmyoblastfusionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinkinaseBsignalingreductionoffoodintakeinresponsetodietaryexcesssignaltransductionSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Protocadherin-15
277
Protocadherin-15
268
9.9
56
0.18
PCD15PCD15Q96QU1Q96QU1celladhesionequilibrioceptionhomophiliccelladhesionviaplasmamembraneadhesionmoleculesinnereardevelopmentphotoreceptorcellmaintenancesensoryperceptionoflightstimulussensoryperceptionofsound
Resistin-like beta
91
Resistin-like beta
76
9.9
74
0.14
RETNBRETNBQ99P86Q99P86responsetobacterium
3-hydroxy-3-methylglutaryl-coenzyme A reductase
526
3-hydroxy-3-methylglutaryl-coenzyme A reductase
561
9.9
66
0.15
HMDHHMDHP04035P04035cholesterolbiosyntheticprocesscoenzymeAmetabolicprocessisoprenoidbiosyntheticprocessnegativeregulationofamyloid-betaclearancenegativeregulationofMAPkinaseactivitynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionsterolbiosyntheticprocessvisuallearning
Glycoprotein hormones alpha chain
83
Follitropin subunit beta
105
9.9
78
0.13
Q96QJ4FSHBQ96QJ4P01225femalegametegenerationfemalepregnancyfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwaypositiveregulationofboneresorptionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationregulationofsignalingreceptoractivitySertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Checkpoint protein HUS1
200
Cell cycle checkpoint protein RAD1
132
9.9
66
0.15
HUS1RAD1O60921O60671cellularresponsetoDNAdamagestimuluscellularresponsetoionizingradiationDNAdamagecheckpointsignalingDNArepairdouble-strandbreakrepairviahomologousrecombinationembryodevelopmentendinginbirthoregghatchingmeioticDNAintegritycheckpointsignalingmitoticDNAreplicationcheckpointsignalingmitoticintra-SDNAdamagecheckpointsignalingnucleotide-excisionrepairproteinphosphorylationregulationofproteinphosphorylationresponsetoUVtelomeremaintenancemeioticrecombinationcheckpointsignalingsubstantianigradevelopment
Chymotrypsinogen A
58
Amyloid-beta precursor protein
324
9.9
85
0.12
CTRAA4P00766P05067digestionproteolysisadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Poly(ADP-ribose) glycohydrolase
599
Poly(ADP-ribose) glycohydrolase
599
10.0
54
0.19
PARGPARGQ9QYM2Q9QYM2ATPgenerationfrompoly-ADP-D-ribosecarbohydratemetabolicprocesscellularresponsetoDNAdamagestimulusdetectionofbacteriumnucleotide-sugarmetabolicprocesspositiveregulationofDNArepairregulationofDNArepairregulationofhistonemodification
Threonine aspartase 1
163
Threonine aspartase 1
293
9.9
91
0.11
TASP1TASP1Q9H6P5Q9H6P5positiveregulationoftranscriptionDNA-templatedproteinmaturationproteolysis
Gremlin-1
122
Gremlin-1
122
9.9
84
0.12
GREM1GREM1O60565O60565animalorganmorphogenesisapoptoticprocesscardiacmusclecelldifferentiationcardiacmusclecellmyoblastdifferentiationcellmigrationinvolvedinsproutingangiogenesiscellmorphogenesiscell-cellsignalingcollagenfibrilorganizationdeterminationofdorsalidentityembryoniclimbmorphogenesislimbdevelopmentmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesisnegativeregulationofapoptoticprocessnegativeregulationofBMPsignalingpathwaynegativeregulationofbonemineralizationnegativeregulationofbonemineralizationinvolvedinbonematurationnegativeregulationofboneremodelingnegativeregulationofbonetrabeculaformationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellgrowthnegativeregulationofchondrocytedifferentiationnegativeregulationofmonocytechemotaxisnegativeregulationofosteoblastdifferentiationnegativeregulationofosteoblastproliferationnegativeregulationofosteoclastproliferationnegativeregulationofpathway-restrictedSMADproteinphosphorylationnegativeregulationoftranscriptionDNA-templatedpositiveregulationofangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcellpopulationproliferationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofreceptorinternalizationpositiveregulationofsignalingreceptoractivitypositiveregulationoftelomeraseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIproximal/distalpatternformationregulationofepithelialtomesenchymaltransitionregulationoffocaladhesionassemblysequesteringofBMPfromreceptorviaBMPbindingsignaltransductionuretericbudformation
Lactotransferrin
390
Lactotransferrin
500
9.9
84
0.12
TRFLTRFLP24627P24627antibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidebonemorphogenesisdefenseresponsetoGram-negativebacteriuminnateimmuneresponseinmucosaironionhomeostasisironiontransportkillingofcellsofanotherorganismmembranedisruptioninanotherorganismnegativeregulationbyhostofviralprocessnegativeregulationofapoptoticprocessnegativeregulationofATP-dependentactivitynegativeregulationofcysteine-typeendopeptidaseactivitynegativeregulationoflipopolysaccharide-mediatedsignalingpathwaynegativeregulationofosteoclastdevelopmentnegativeregulationofsingle-speciesbiofilmformationinoronhostorganismnegativeregulationoftumornecrosisfactor(ligand)superfamilymember11productionnegativeregulationofviralgenomereplicationossificationpositiveregulationofbonemineralizationinvolvedinbonematurationpositiveregulationofchondrocyteproliferationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofosteoblastdifferentiationpositiveregulationofosteoblastproliferationpositiveregulationoftoll-likereceptor4signalingpathwayproteolysisregulationofcytokineproductionregulationoftumornecrosisfactorproduction
Protein fem-1 homolog C
205
Protein fem-1 homolog C
205
9.9
52
0.2
FEM1CFEM1CQ96JP0Q96JP0proteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitinationubiquitin-dependentproteincatabolicprocessubiquitin-dependentproteincatabolicprocessviatheC-enddegronrulepathway
Speckle targeted PIP5K1A-regulated poly(A) polymerase
372
Speckle targeted PIP5K1A-regulated poly(A) polymerase
372
9.9
57
0.18
STPAPSTPAPQ9H6E5Q9H6E5mRNApolyadenylationpre-mRNAcleavagerequiredforpolyadenylation"RNA3-endprocessing"snRNAprocessing"U6snRNA3-endprocessing"
Trypsin-3
121
Amyloid-beta precursor protein
324
9.9
84
0.12
TRY3A4P35030P05067antimicrobialhumoralresponsedigestionendothelialcellmigrationproteolysiszymogenactivationadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Serine protease hepsin
150
Serine protease hepsin
277
9.9
81
0.12
HEPSHEPSP05981P05981basementmembranedisassemblycochleamorphogenesisdetectionofmechanicalstimulusinvolvedinsensoryperceptionofsoundnegativeregulationofapoptoticprocessnegativeregulationofepithelialcellproliferationnegativeregulationofepithelialtomesenchymaltransitionpilomotorreflexpositiveregulationbyhostofviraltranscriptionpositiveregulationofcellgrowthpositiveregulationofgeneexpressionpositiveregulationofhepatocyteproliferationpositiveregulationofplasminogenactivationpositiveregulationofthyroidhormonegenerationpotassiumiontransmembranetransportproteolysisregulationofcellshaperesponsetothyroidhormone
Proprotein convertase subtilisin/kexin type 9
378
Low-density lipoprotein receptor
325
9.9
71
0.14
PCSK9LDLRQ8NBP7Q59FQ1apoptoticprocesscellularresponsetoinsulinstimuluscellularresponsetostarvationcholesterolhomeostasischolesterolmetabolicprocesskidneydevelopmentlipoproteinmetabolicprocessliverdevelopmentlow-densitylipoproteinparticlereceptorcatabolicprocesslysosomaltransportnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationoflow-densitylipoproteinparticlereceptorbindingnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofreceptorinternalizationnegativeregulationofreceptorrecyclingnegativeregulationofreceptor-mediatedendocytosisinvolvedincholesteroltransportnegativeregulationofsodiumiontransmembranetransporteractivityneurogenesisneurondifferentiationphospholipidmetabolicprocesspositiveregulationoflow-densitylipoproteinparticlereceptorcatabolicprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofreceptorinternalizationproteinautoprocessingregulationofneuronapoptoticprocessregulationofsignalingreceptoractivitytriglyceridemetabolicprocessamyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessarterymorphogenesiscellularresponsetofattyacidcellularresponsetolow-densitylipoproteinparticlestimuluscholesterolimportcholesteroltransportendocytosishigh-densitylipoproteinparticleclearanceintestinalcholesterolabsorptionlipidmetabolicprocesslipoproteincatabolicprocesslong-termmemorylow-densitylipoproteinparticleclearancenegativeregulationofamyloidfibrilformationnegativeregulationofastrocyteactivationnegativeregulationofgeneexpressionnegativeregulationofmicroglialcellactivationnegativeregulationofproteinmetabolicprocessphagocytosisphospholipidtransportplasmalipoproteinparticleclearancepositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationoflysosomalproteincatabolicprocesspositiveregulationoftriglyceridebiosyntheticprocessreceptor-mediatedendocytosisreceptor-mediatedendocytosisinvolvedincholesteroltransportregulationofcholesterolmetabolicprocessregulationofphosphatidylcholinecatabolicprocessregulationofproteinmetabolicprocessresponsetocaloricrestriction
Fibrinogen beta chain
316
Fibrinogen gamma chain
165
9.9
70
0.14
FIBBFIBGP02675Q53Y18adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Leucine carboxyl methyltransferase 1
136
Leucine carboxyl methyltransferase 1
30
9.9
63
0.16
LCMT1LCMT1Q9UIC8Q9UIC8C-terminalproteinmethylationG2/Mtransitionofmitoticcellcyclenegativeregulationofprotein-containingcomplexassemblyproteinmethylationproteinmodificationprocessregulationofapoptoticprocessregulationofglucosemetabolicprocessregulationofmitoticcellcyclespindleassemblycheckpoint
Serotransferrin
38
Serotransferrin
198
9.9
89
0.11
TRFETRFEP02787P02787actinfilamentorganizationantibacterialhumoralresponsecellularironionhomeostasiscellularresponsetoironionERK1andERK2cascadeironionhomeostasisironiontransportosteoclastdifferentiationpositiveregulationofboneresorptionpositiveregulationofcellmotilitypositiveregulationofphosphorylationpositiveregulationofreceptor-mediatedendocytosispositiveregulationoftranscriptionDNA-templatedregulationofironiontransportregulationofproteinstabilityretinahomeostasisSMADproteinsignaltransduction
Properdin
89
Properdin
391
9.9
60
0.17
PROPPROPP27918P27918complementactivationcomplementactivationalternativepathwaydefenseresponsetobacteriumimmuneresponsepositiveregulationofimmuneresponsepositiveregulationofopsonization
Isovaleryl-CoA dehydrogenase, mitochondrial
339
Isovaleryl-CoA dehydrogenase, mitochondrial
339
9.9
97
0.1
IVDIVDP26440P26440branched-chainaminoacidcatabolicprocessfattyacidbeta-oxidationusingacyl-CoAdehydrogenaseleucinecatabolicprocess
Tumor necrosis factor receptor superfamily member 9
47
Tumor necrosis factor receptor superfamily member 9
44
9.9
85
0.12
TNR9TNR9P20334P20334apoptoticprocessnegativeregulationofcellpopulationproliferationregulationofcellpopulationproliferationregulationofimmatureTcellproliferationinthymus
Prostasin
70
Pancreatic trypsin inhibitor
49
9.9
97
0.1
PRSS8BPT1Q16651P00974positiveregulationofsodiumiontransportproteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
MORC family CW-type zinc finger protein 3
413
MORC family CW-type zinc finger protein 3
435
9.9
79
0.13
MORC3MORC3Q14149Q14149innateimmuneresponsemaintenanceofproteinlocationinnucleusnegativeregulationoffibroblastproliferationpeptidyl-serinephosphorylationpositiveregulationofcellularsenescencepost-embryonicdevelopmentproteinphosphorylationproteinstabilization
Integrin beta-2
36
Integrin beta-2
467
9.9
74
0.14
ITB2ITB2P05107P05107amyloid-betaclearanceapoptoticprocesscelladhesioncelladhesionmediatedbyintegrincellmigrationcell-celladhesioncell-celladhesionviaplasma-membraneadhesionmoleculescell-cellsignalingcell-matrixadhesioncellularresponsetolow-densitylipoproteinparticlestimulusendodermalcelldifferentiationheterotypiccell-celladhesioninflammatoryresponseintegrin-mediatedsignalingpathwayleukocytecell-celladhesionmicroglialcellactivationnegativeregulationofdopaminemetabolicprocessneutrophilchemotaxisneutrophilmigrationphagocytosisengulfmentpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofneurondeathpositiveregulationofneutrophildegranulationpositiveregulationofprostaglandin-Esynthaseactivitypositiveregulationofproteintargetingtomembranepositiveregulationofsuperoxideaniongenerationreceptorclusteringreceptorinternalizationreceptor-mediatedendocytosisregulationofcellshaperegulationofpeptidyl-tyrosinephosphorylation
DNA repair protein XRCC4
128
DNA repair protein XRCC4
130
9.9
61
0.17
XRCC4XRCC4Q13426Q13426DNAligationinvolvedinDNArepairdouble-strandbreakrepairdouble-strandbreakrepairvianonhomologousendjoiningimmunoglobulinV(D)Jrecombinationpositiveregulationofligaseactivitypositiveregulationofphosphatidylserineexposureonapoptoticcellsurfaceproteinlocalizationtositeofdouble-strandbreakresponsetoX-ray
Tumor necrosis factor ligand superfamily member 13
202
Tumor necrosis factor ligand superfamily member 13
187
9.9
93
0.11
TNF13TNF13Q9D777Q9D777germinalcenterformationimmunoglobulinmediatedimmuneresponsepositiveregulationofcellpopulationproliferationpositiveregulationofgerminalcenterformationpositiveregulationofisotypeswitchingtoIgAisotypesregulationofimmuneresponse
Tyrosine-protein kinase ABL1
330
Tyrosine-protein kinase ABL1
330
9.9
63
0.16
ABL1ABL1P00519P00519actincytoskeletonorganizationactinfilamentpolymerizationactivatedTcellproliferationactivationofproteinkinaseCactivityalpha-betaTcelldifferentiationassociativelearningautophagyBcellproliferationinvolvedinimmuneresponseBcellreceptorsignalingpathwayB-1BcellhomeostasisBergmannglialcelldifferentiationBMPsignalingpathwaycell-celladhesioncellularresponsetoDNAdamagestimuluscellularresponsetodopaminecellularresponsetohydrogenperoxidecellularresponsetolipopolysaccharidecellularresponsetooxidativestresscellularresponsetotransforminggrowthfactorbetastimuluscellularsenescencecerebellummorphogenesiscirculatorysystemdevelopmentDN4thymocytedifferentiationDNAconformationchangeDNAdamageinducedproteinphosphorylationendocytosisendothelialcellmigrationepidermalgrowthfactorreceptorsignalingpathwayERK1andERK2cascadeestablishmentoflocalizationincellFc-gammareceptorsignalingpathwayinvolvedinphagocytosisI-kappaBkinase/NF-kappaBsignalingintegrin-mediatedsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagemicrospikeassemblymismatchrepairmitochondrialdepolarizationmitoticcellcyclenegativeregulationofBMPsignalingpathwaynegativeregulationofcell-celladhesionnegativeregulationofcellularsenescencenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofERK1andERK2cascadenegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmitoticcellcyclenegativeregulationofphospholipaseCactivitynegativeregulationofproteinserine/threoninekinaseactivitynegativeregulationofubiquitin-proteintransferaseactivityneuraltubeclosureneuroepithelialcelldifferentiationneuromuscularprocesscontrollingbalanceneurondeathneurondifferentiationneuropilinsignalingpathwaypeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypodocyteapoptoticprocesspositiveregulationofactincytoskeletonreorganizationpositiveregulationofactinfilamentbindingpositiveregulationofapoptoticprocesspositiveregulationofbloodvesselbranchingpositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofdendritedevelopmentpositiveregulationofendothelialcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofestablishmentofTcellpolaritypositiveregulationofextracellularmatrixorganizationpositiveregulationoffibroblastproliferationpositiveregulationoffocaladhesionassemblypositiveregulationofhydrogenperoxide-mediatedprogrammedcelldeathpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-2productionpositiveregulationofmicrotubulebindingpositiveregulationofmitoticcellcyclepositiveregulationofneuronapoptoticprocesspositiveregulationofosteoblastproliferationpositiveregulationofoxidoreductaseactivitypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofstressfiberassemblypositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofTcellmigrationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvasoconstrictionpositiveregulationofWntsignalingpathwayplanarcellpolaritypathwaypost-embryonicdevelopmentproteinautophosphorylationproteinlocalizationtocytoplasmicmicrotubuleplus-endproteinmodificationprocessproteinphosphorylationregulationofactincytoskeletonorganizationregulationofactincytoskeletonreorganizationregulationofapoptoticprocessregulationofautophagyregulationofaxonextensionregulationofCdc42proteinsignaltransductionregulationofcelladhesionregulationofcellcycleregulationofcellmotilityregulationofendocytosisregulationofhematopoieticstemcelldifferentiationregulationofmicrotubulepolymerizationregulationofmodificationofsynapticstructureregulationofresponsetoDNAdamagestimulusregulationofTcelldifferentiationregulationoftranscriptionDNA-templatedresponsetoendoplasmicreticulumstressresponsetoepinephrineresponsetooxidativestressresponsetoxenobioticstimulussignaltransductioninresponsetoDNAdamagespleendevelopmentsubstrateadhesion-dependentcellspreadingTcellreceptorsignalingpathwaythymusdevelopmenttransitionalonestageBcelldifferentiation
PRKCA-binding protein
44
PRKCA-binding protein
44
9.9
58
0.17
PICK1PICK1Q9NRD5Q9NRD5cellularresponsetodecreasedoxygenlevelscellularresponsetoglucosestarvationdendriticspinemaintenancedendriticspineorganizationDNAmethylationinvolvedinembryodevelopmentDNAmethylationinvolvedingametegenerationglialcelldevelopmentintracellularproteintransportlong-termsynapticdepressionmonoaminetransportnegativeregulationofArp2/3complex-mediatedactinnucleationneuronalionchannelclusteringpositiveregulationofreceptorinternalizationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteinphosphorylationreceptorclusteringregulationofArp2/3complex-mediatedactinnucleationregulationofinsulinsecretionretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulum
Tumor necrosis factor receptor superfamily member 4
87
Tumor necrosis factor receptor superfamily member 4
43
9.9
75
0.14
TNR4TNR4P43489P43489immuneresponseinflammatoryresponsenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationoftranscriptionDNA-templatedpositiveregulationofBcellproliferationpositiveregulationofimmunoglobulinproductionTcellproliferation
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
263
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
254
10.0
90
0.11
IDH3AIDH3BP50213O43837carbohydratemetabolicprocessisocitratemetabolicprocesstricarboxylicacidcycle2-oxoglutaratemetabolicprocessNADHmetabolicprocess
Neuroblastoma suppressor of tumorigenicity 1
63
Neuroblastoma suppressor of tumorigenicity 1
63
10.0
80
0.13
NBL1NBL1P41271P41271animalorganmorphogenesisdeterminationofdorsalidentitynegativeregulationofBMPsignalingpathwaynegativeregulationofmonocytechemotaxisnervoussystemdevelopmentneuronprojectionmorphogenesispositiveregulationofneurondifferentiationsequesteringofBMPfromreceptorviaBMPbindingsequesteringofBMPinextracellularmatrix
Protein S100-A3
23
Protein S100-A3
14
10.0
72
0.14
S10A3S10A3P33764P33764
Prosaposin
66
Prosaposin
66
10.0
81
0.12
SAPSAPQ61207Q61207adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayantigenprocessingandpresentationcellularresponsetoorganicsubstanceceramidemetabolicprocesscerebellarPurkinjecelldifferentiationcochleadevelopmentcorneocytedevelopmentcornifiedenvelopeassemblydevelopmentalgrowthepithelialcelldifferentiationinvolvedinprostateglanddevelopmentgalactosylceramidecatabolicprocessgangliosideGM1transporttomembranegeneexpressionglucosylceramidemetabolicprocessglycolipidmetabolicprocessinclusionbodyassemblyintracellularproteintransportlysosomalproteincatabolicprocesslysosomaltransportmembranelipidmetabolicprocessmicturitionmyelinationnegativeregulationofhydrogenperoxide-inducedcelldeathnervoussystemprocessneuromuscularprocesscontrollingbalanceNKTcelldifferentiationpositiveregulationofbeta-galactosidaseactivitypositiveregulationofhydrolaseactivitypositiveregulationofMAPKcascadeprostateglandgrowthproteinsecretionregulationoflipidmetabolicprocessregulationofMAPKcascadesensoryperceptionofsoundsphingolipidmetabolicprocesswalkingbehavior
Transforming growth factor beta-1 proprotein
355
Transforming growth factor beta-1 proprotein
293
10.0
75
0.13
TGFB1TGFB1P07200P07200adaptiveimmuneresponsebasedonsomaticrecombinationofimmunereceptorsbuiltfromimmunoglobulinsuperfamilydomainsaorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaybranchelongationinvolvedinmammaryglandductbranchingbronchioledevelopmentcellmigrationcellmorphogenesiscell-celljunctionorganizationcellularcalciumionhomeostasiscellularresponsetoionizingradiationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetoviruschondrocytedifferentiationcolumnar/cuboidalepithelialcellmaturationcommon-partnerSMADproteinphosphorylationembryonicliverdevelopmentenamelmineralizationendodermdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialcellproliferationepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayfacemorphogenesisgeneexpressiongermcellmigrationhematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponseLangerhanscelldifferentiationlensfibercelldifferentiationlipopolysaccharide-mediatedsignalingpathwaylungalveolusdevelopmentlymphnodedevelopmentmammaryglandbranchinginvolvedinthelarcheMAPKcascademembraneproteinintracellulardomainproteolysismusclecellcellularhomeostasisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofepithelialcellproliferationnegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofinterleukin-17productionnegativeregulationofmacrophagecytokineproductionnegativeregulationofmyoblastdifferentiationnegativeregulationofossificationnegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationofTcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneuraltubeclosureNotchsignalingpathwayoligodendrocytedevelopmentossificationinvolvedinboneremodelingosteoclastdifferentiationpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocessphospholipidhomeostasispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofhistoneacetylationpositiveregulationofhistonedeacetylationpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofodontogenesispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorclusteringpositiveregulationofregulatoryTcelldifferentiationpositiveregulationofSMADproteinsignaltransductionpositiveregulationofstemcellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofactincytoskeletonreorganizationregulationofbindingregulationofbranchinginvolvedinmammaryglandductmorphogenesisregulationofcartilagedevelopmentregulationofcellpopulationproliferationregulationofDNAbindingregulationofinterleukin-23productionregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofsodiumiontransportregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulatoryTcelldifferentiationresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductionstemcellproliferationsurfactanthomeostasisTcellhomeostasisTcellproliferationtoleranceinductiontoselfantigentransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmenturetericbuddevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
Secreted frizzled-related protein 3
96
Secreted frizzled-related protein 3
96
10.0
73
0.14
SFRP3SFRP3P97401P97401canonicalWntsignalingpathwaycochleamorphogenesisconvergentextensioninvolvedinorganogenesisepithelialcelldevelopmenthepatocytedifferentiationinnerearmorphogenesisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcartilagedevelopmentnegativeregulationofcelldevelopmentnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofhepatocytedifferentiationnegativeregulationofWntsignalingpathwayneuralcrestcelldifferentiationpositiveregulationofapoptoticprocesspositiveregulationoffatcelldifferentiationsomitedevelopment
Potassium voltage-gated channel subfamily D member 3
93
Potassium voltage-gated channel subfamily D member 3
110
10.0
72
0.14
KCND3KCND3Q62897Q62897cellularresponsetoBMPstimulusmembranerepolarizationmembranerepolarizationduringventricularcardiacmusclecellactionpotentialpotassiumionexportacrossplasmamembranepotassiumionimportacrossplasmamembranepotassiumiontransmembranetransportpotassiumiontransportproteinhomooligomerizationregulationofheartratebycardiacconductionregulationofiontransmembranetransportventricularcardiacmusclecellmembranerepolarization
Mitogen-activated protein kinase kinase kinase kinase 4
202
Mitogen-activated protein kinase kinase kinase kinase 4
202
10.0
67
0.15
M4K4M4K4O95819O95819intracellularsignaltransductionMAPKcascadenegativeregulationofapoptoticprocessnegativeregulationofcell-matrixadhesionneuronprojectionmorphogenesispositiveregulationofARFproteinsignaltransductionpositiveregulationofcellmigrationpositiveregulationoffocaladhesionassemblypositiveregulationoffocaladhesiondisassemblypositiveregulationofGTPaseactivitypositiveregulationofkeratinocytemigrationproteinphosphorylationregulationofJNKcascaderegulationofMAPKcascade
Vascular endothelial growth factor B
124
Vascular endothelial growth factor B
72
9.9
72
0.14
VEGFBVEGFBP49765P49765cardiacmusclecontractioncoronaryvasculaturedevelopmentinductionofpositivechemotaxisnegativeregulationofapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofneuronapoptoticprocesspositiveregulationofangiogenesispositiveregulationofcelldivisionpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofmastcellchemotaxispositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofvascularwoundhealingproteinO-linkedglycosylationresponsetohypoxiasproutingangiogenesisvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathway
Inhibin beta A chain
350
Inhibin beta A chain
390
9.9
73
0.14
INHBAINHBAP08476P08476activinreceptorsignalingpathwaycelldifferentiationcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularresponsetocholesterolcellularresponsetofollicle-stimulatinghormonestimulusdefenseresponseendodermalcelldifferentiationerythrocytedifferentiationextrinsicapoptoticsignalingpathwayeyeliddevelopmentincamera-typeeyeGABAergicneurondifferentiationhairfollicledevelopmenthematopoieticprogenitorcelldifferentiationhemoglobinbiosyntheticprocessmalegonaddevelopmentmesodermalcelldifferentiationmulticellularorganismagingnegativeregulationofBcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationoffollicle-stimulatinghormonesecretionnegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofinterferon-gammaproductionnegativeregulationofmacrophagedifferentiationnegativeregulationofphosphorylationnervoussystemdevelopmentodontogenesisovarianfollicledevelopmentpositiveregulationoferythrocytedifferentiationpositiveregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandpositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofgeneexpressionpositiveregulationofovulationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprogesteronesecretionregulationoffollicle-stimulatinghormonesecretionregulationoftranscriptionbyRNApolymeraseIIresponsetoxenobioticstimulusroofofmouthdevelopmentSMADproteinsignaltransductionstriatalmediumspinyneurondifferentiationtranscriptionbyRNApolymeraseII
Complement C4-A
876
Complement C4-A
1595
9.9
69
0.15
CO4ACO4AP0C0L4P0C0L4complementactivationcomplementactivationclassicalpathwayinflammatoryresponseinnateimmuneresponsepositiveregulationofapoptoticcellclearancepositiveregulationofimmuneresponsepositiveregulationofopsonization
Resistin
55
Resistin
67
9.9
67
0.15
RETNRETNQ99P87Q99P87fatcelldifferentiationnegativeregulationoffeedingbehaviorpositiveregulationofcollagenmetabolicprocesspositiveregulationofprogesteronesecretionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsynaptictransmissionresponsetoinsulin
Cytochrome b
323
Cytochrome b-c1 complex subunit 8
45
9.9
52
0.19
CYBQCR8P00157P13271mitochondrialelectrontransportubiquinoltocytochromecrespiratoryelectrontransportchain
Bone morphogenetic protein 2
360
Bone morphogenetic protein 2
296
10.0
75
0.13
BMP2BMP2P12643P12643ameloblastdifferentiationanimalorganmorphogenesisaorticvalvedevelopmentastrocytedifferentiationatrioventricularcanalmorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwayBMPsignalingpathwayinvolvedinheartdevelopmentBMPsignalingpathwayinvolvedinheartinductionbonemineralizationbonemineralizationinvolvedinbonematurationbranchinginvolvedinuretericbudmorphogenesiscardiacatriumformationcardiacepithelialtomesenchymaltransitioncardiacjellydevelopmentcardiacmusclecelldifferentiationcardiacmuscletissuemorphogenesiscardiocytedifferentiationcellfatecommitmentcell-cellsignalingcellularresponsetoBMPstimuluscellularresponsetoorganiccycliccompoundchondrocytedifferentiationcorticotropinhormonesecretingcelldifferentiationembryonichearttubeanterior/posteriorpatternspecificationendocardialcushionformationendocardialcushionmorphogenesisepithelialtomesenchymaltransitionheartdevelopmentinuteroembryonicdevelopmentinflammatoryresponseinnereardevelopmentmesenchymalcelldifferentiationmesenchymalcellproliferationinvolvedinuretericbuddevelopmentmesenchymedevelopmentnegativeregulationofaldosteronebiosyntheticprocessnegativeregulationofcalcium-independentcell-celladhesionnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcardiacmusclecelldifferentiationnegativeregulationofcellcyclenegativeregulationofcellpopulationproliferationnegativeregulationofcortisolbiosyntheticprocessnegativeregulationofgeneexpressionnegativeregulationofinsulin-likegrowthfactorreceptorsignalingpathwaynegativeregulationofMAPkinaseactivitynegativeregulationofsmoothmusclecellproliferationnegativeregulationofsteroidbiosyntheticprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofWntsignalingpathwayinvolvedinheartdevelopmentNotchsignalingpathwayodontogenesisofdentin-containingtoothosteoblastdifferentiationpathway-restrictedSMADproteinphosphorylationpericardiumdevelopmentpositiveregulationofapoptoticprocesspositiveregulationofastrocytedifferentiationpositiveregulationofbonemineralizationpositiveregulationofcartilagedevelopmentpositiveregulationofcellmigrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcelldifferentiationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixconstituentsecretionpositiveregulationoffatcelldifferentiationpositiveregulationofgeneexpressionpositiveregulationofMAPKcascadepositiveregulationofmiRNAtranscriptionpositiveregulationofneurondifferentiationpositiveregulationofodontogenesispositiveregulationofossificationpositiveregulationofosteoblastdifferentiationpositiveregulationofosteoblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofperoxisomeproliferatoractivatedreceptorsignalingpathwaypositiveregulationofphosphataseactivitypositiveregulationofproteinbindingpositiveregulationofproteinphosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimuluspositiveregulationoftranscriptionDNA-templatedpositiveregulationofWntsignalingpathwaypositiveregulationofWntsignalingpathwaybyBMPsignalingpathwayproteindestabilizationproteinphosphorylationproteoglycanmetabolicprocessregulationofodontogenesisofdentin-containingtoothregulationoftranscriptionDNA-templatedresponsetobacteriumresponsetohypoxiaskeletalsystemdevelopmentSMADproteinsignaltransductiontelencephalondevelopmenttelencephalonregionalizationthyroid-stimulatinghormone-secretingcelldifferentiationtranscriptionbyRNApolymeraseIIWntsignalingpathway
Ribonuclease pancreatic
100
Ribonuclease inhibitor
409
10.0
69
0.15
RNAS1RINIP07998P13489defenseresponsetoGram-positivebacteriumRNAphosphodiesterbondhydrolysismRNAcatabolicprocessregulationofangiogenesis
C-C motif chemokine 16
37
C-C motif chemokine 16
76
9.9
75
0.13
CCL16CCL16O15467O15467cellcommunicationcell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
Protein SEC13 homolog
299
Protein SEC13 homolog
299
9.8
56
0.18
SEC13SEC13P55735P55735COPII-coatedvesiclebuddingCOPII-coatedvesiclecargoloadingintracellularproteintransportmRNAtransportnegativeregulationofTORC1signalingnucleocytoplasmictransportpositiveregulationofTORsignalingpositiveregulationofTORC1signalingproteinexitfromendoplasmicreticulumproteinimportintonucleus
Ornithine decarboxylase
70
Ornithine decarboxylase
360
9.8
88
0.12
DCORDCORP11926P11926cellpopulationproliferationkidneydevelopmentpolyaminemetabolicprocesspositiveregulationofcellpopulationproliferationputrescinebiosyntheticprocessfromornithineregulationofproteincatabolicprocessresponsetovirus
Protein ERGIC-53
198
Protein ERGIC-53
198
9.7
73
0.14
LMAN1LMAN1Q62902Q62902endoplasmicreticulumorganizationendoplasmicreticulumtoGolgivesicle-mediatedtransportGolgiorganizationpositiveregulationoforganelleorganizationproteintransport
Coagulation factor IX
335
Coagulation factor IX
170
9.7
74
0.14
FA9FA9P00740P00740bloodcoagulationbloodcoagulationintrinsicpathwayproteolysiszymogenactivation
Interleukin-12 subunit beta
199
Interleukin-23 subunit alpha
77
9.8
80
0.13
IL12BIL23AP29460Q9NPF7cellmigrationcellularresponsetointerferon-gammacellularresponsetolipopolysaccharidecytokine-mediatedsignalingpathwaydefenseresponsetoGram-negativebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponsenaturalkillercellactivationnaturalkillercellactivationinvolvedinimmuneresponsenegativeregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisnegativeregulationofinflammatoryresponsetoantigenicstimulusnegativeregulationofinterleukin-10productionnegativeregulationofinterleukin-17productionnegativeregulationofproteinsecretionnegativeregulationofsmoothmusclecellproliferationnegativeregulationofvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofactivatedTcellproliferationpositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcelladhesionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-17productionpositiveregulationoflymphocyteproliferationpositiveregulationofmemoryTcelldifferentiationpositiveregulationofmononuclearcellproliferationpositiveregulationofnaturalkillercellactivationpositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationofnaturalkillercellproliferationpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofNKTcellactivationpositiveregulationofNKTcellproliferationpositiveregulationofosteoclastdifferentiationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellapoptoticprocesspositiveregulationofTcellmediatedcytotoxicitypositiveregulationofTcellproliferationpositiveregulationofT-helper1typeimmuneresponsepositiveregulationofT-helper17celllineagecommitmentpositiveregulationofT-helper17typeimmuneresponsepositiveregulationoftissueremodelingpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofcytokineproductionregulationoftyrosinephosphorylationofSTATproteinresponsetoUV-BsensoryperceptionofpainsexualreproductionTcellproliferationT-helper1typeimmuneresponseT-helpercelldifferentiationinflammatoryresponseinnateimmuneresponsepositiveregulationofneutrophilchemotaxispositiveregulationoftranscriptionbyRNApolymeraseIItissueremodeling
Glycoprotein hormones alpha chain
111
Follitropin subunit beta
112
9.7
81
0.13
Q96QJ4FSHBQ96QJ4P01225femalegametegenerationfemalepregnancyfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwaypositiveregulationofboneresorptionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationregulationofsignalingreceptoractivitySertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Neurturin
165
Neurturin
164
9.7
74
0.14
NRTNNRTNQ99748Q99748MAPKcascadenervedevelopmentnervoussystemdevelopmentneuralcrestcellmigrationneuronprojectiondevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathway
Annexin A2
9
Protein S100-A10
83
9.7
63
0.16
ANXA2S10AAP07356P60903angiogenesisbodyfluidsecretioncollagenfibrilorganizationfibrinolysismembraneraftassemblymRNAtranscriptionbyRNApolymeraseIInegativeregulationoflow-densitylipoproteinparticlereceptorcatabolicprocessnegativeregulationofreceptorinternalizationosteoclastdevelopmentpositiveregulationofbindingpositiveregulationofexocytosispositiveregulationoffibroblastproliferationpositiveregulationoflow-densitylipoproteinparticleclearancepositiveregulationoflow-densitylipoproteinparticlereceptorbindingpositiveregulationoflow-densitylipoproteinreceptoractivitypositiveregulationofplasmamembranerepairpositiveregulationofplasminogenactivationpositiveregulationofproteinphosphorylationpositiveregulationofreceptorrecyclingpositiveregulationofreceptor-mediatedendocytosisinvolvedincholesteroltransportpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvacuoleorganizationpositiveregulationofvesiclefusionproteinlocalizationtoplasmamembraneregulationofneurogenesisvesiclebuddingfrommembranepositiveregulationoffocaladhesionassemblypositiveregulationofGTPaseactivitypositiveregulationofstressfiberassemblypositiveregulationofsubstrateadhesion-dependentcellspreading
Titin
32733
Titin
32733
9.7
79
0.13
TITINTITINQ8WZ42Q8WZ42cardiacmusclecelldevelopmentcardiacmusclecontractioncardiacmusclehypertrophycardiacmuscletissuemorphogenesiscardiacmyofibrilassemblydetectionofmusclestretchmitoticchromosomecondensationmusclecontractionpositiveregulationofgeneexpressionpositiveregulationofproteinsecretionproteinkinaseAsignalingregulationofcatalyticactivityregulationofproteinkinaseactivityresponsetocalciumionsarcomereorganizationsarcomerogenesisskeletalmusclemyosinthickfilamentassemblyskeletalmusclethinfilamentassemblystriatedmusclecontraction
Prosaposin
106
Prosaposin
106
9.8
75
0.14
SAPSAPQ61207Q61207adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayantigenprocessingandpresentationcellularresponsetoorganicsubstanceceramidemetabolicprocesscerebellarPurkinjecelldifferentiationcochleadevelopmentcorneocytedevelopmentcornifiedenvelopeassemblydevelopmentalgrowthepithelialcelldifferentiationinvolvedinprostateglanddevelopmentgalactosylceramidecatabolicprocessgangliosideGM1transporttomembranegeneexpressionglucosylceramidemetabolicprocessglycolipidmetabolicprocessinclusionbodyassemblyintracellularproteintransportlysosomalproteincatabolicprocesslysosomaltransportmembranelipidmetabolicprocessmicturitionmyelinationnegativeregulationofhydrogenperoxide-inducedcelldeathnervoussystemprocessneuromuscularprocesscontrollingbalanceNKTcelldifferentiationpositiveregulationofbeta-galactosidaseactivitypositiveregulationofhydrolaseactivitypositiveregulationofMAPKcascadeprostateglandgrowthproteinsecretionregulationoflipidmetabolicprocessregulationofMAPKcascadesensoryperceptionofsoundsphingolipidmetabolicprocesswalkingbehavior
Bone morphogenetic protein 2
360
Bone morphogenetic protein 2
325
9.8
81
0.13
BMP2BMP2P12643P12643ameloblastdifferentiationanimalorganmorphogenesisaorticvalvedevelopmentastrocytedifferentiationatrioventricularcanalmorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwayBMPsignalingpathwayinvolvedinheartdevelopmentBMPsignalingpathwayinvolvedinheartinductionbonemineralizationbonemineralizationinvolvedinbonematurationbranchinginvolvedinuretericbudmorphogenesiscardiacatriumformationcardiacepithelialtomesenchymaltransitioncardiacjellydevelopmentcardiacmusclecelldifferentiationcardiacmuscletissuemorphogenesiscardiocytedifferentiationcellfatecommitmentcell-cellsignalingcellularresponsetoBMPstimuluscellularresponsetoorganiccycliccompoundchondrocytedifferentiationcorticotropinhormonesecretingcelldifferentiationembryonichearttubeanterior/posteriorpatternspecificationendocardialcushionformationendocardialcushionmorphogenesisepithelialtomesenchymaltransitionheartdevelopmentinuteroembryonicdevelopmentinflammatoryresponseinnereardevelopmentmesenchymalcelldifferentiationmesenchymalcellproliferationinvolvedinuretericbuddevelopmentmesenchymedevelopmentnegativeregulationofaldosteronebiosyntheticprocessnegativeregulationofcalcium-independentcell-celladhesionnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcardiacmusclecelldifferentiationnegativeregulationofcellcyclenegativeregulationofcellpopulationproliferationnegativeregulationofcortisolbiosyntheticprocessnegativeregulationofgeneexpressionnegativeregulationofinsulin-likegrowthfactorreceptorsignalingpathwaynegativeregulationofMAPkinaseactivitynegativeregulationofsmoothmusclecellproliferationnegativeregulationofsteroidbiosyntheticprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofWntsignalingpathwayinvolvedinheartdevelopmentNotchsignalingpathwayodontogenesisofdentin-containingtoothosteoblastdifferentiationpathway-restrictedSMADproteinphosphorylationpericardiumdevelopmentpositiveregulationofapoptoticprocesspositiveregulationofastrocytedifferentiationpositiveregulationofbonemineralizationpositiveregulationofcartilagedevelopmentpositiveregulationofcellmigrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcelldifferentiationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixconstituentsecretionpositiveregulationoffatcelldifferentiationpositiveregulationofgeneexpressionpositiveregulationofMAPKcascadepositiveregulationofmiRNAtranscriptionpositiveregulationofneurondifferentiationpositiveregulationofodontogenesispositiveregulationofossificationpositiveregulationofosteoblastdifferentiationpositiveregulationofosteoblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofperoxisomeproliferatoractivatedreceptorsignalingpathwaypositiveregulationofphosphataseactivitypositiveregulationofproteinbindingpositiveregulationofproteinphosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimuluspositiveregulationoftranscriptionDNA-templatedpositiveregulationofWntsignalingpathwaypositiveregulationofWntsignalingpathwaybyBMPsignalingpathwayproteindestabilizationproteinphosphorylationproteoglycanmetabolicprocessregulationofodontogenesisofdentin-containingtoothregulationoftranscriptionDNA-templatedresponsetobacteriumresponsetohypoxiaskeletalsystemdevelopmentSMADproteinsignaltransductiontelencephalondevelopmenttelencephalonregionalizationthyroid-stimulatinghormone-secretingcelldifferentiationtranscriptionbyRNApolymeraseIIWntsignalingpathway
Trifunctional purine biosynthetic protein adenosine-3
62
Trifunctional purine biosynthetic protein adenosine-3
322
9.8
78
0.13
PUR2PUR2P22102P22102"denovoAMPbiosyntheticprocess""denovoIMPbiosyntheticprocess""denovoXMPbiosyntheticprocess"adeninebiosyntheticprocessbrainstemdevelopmentcerebellumdevelopmentcerebralcortexdevelopmentglycinemetabolicprocessGMPbiosyntheticprocesspurinenucleotidebiosyntheticprocesspurineribonucleosidemonophosphatebiosyntheticprocessresponsetoinorganicsubstanceresponsetoorganicsubstancetetrahydrofolatebiosyntheticprocess
ADP-sugar pyrophosphatase
76
ADP-sugar pyrophosphatase
126
9.8
67
0.15
NUDT5NUDT5Q9UKK9Q9UKK9ATPgenerationfrompoly-ADP-D-ribosechromatinremodelingD-ribosecatabolicprocessnucleobase-containingsmallmoleculemetabolicprocessnucleosidephosphatemetabolicprocessnucleotidemetabolicprocessribonucleosidediphosphatecatabolicprocessribosephosphatemetabolicprocess
C-C motif chemokine 17
34
C-C motif chemokine 17
57
9.8
55
0.18
CCL17CCL17Q92583Q92583antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisnegativeregulationofmyoblastdifferentiationneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
Progesterone receptor
603
Progesterone receptor
619
9.8
70
0.15
PRGRPRGRP06401P06401cell-cellsignalingglandularepithelialcellmaturationintracellularsteroidhormonereceptorsignalingpathwaylungalveolusdevelopmentnegativeregulationofgeneexpressionovulationfromovarianfollicleparacrinesignalingpositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronereceptorsignalingpathwayregulationofepithelialcellproliferationregulationoftranscriptionbyRNApolymeraseIIsignaltransductiontertiarybranchinginvolvedinmammaryglandductmorphogenesis
Neurogenic locus notch homolog protein 1
149
Neurogenic locus notch homolog protein 1
206
9.8
77
0.13
NOTC1NOTC1P46531P46531animalorganregenerationaorticvalvemorphogenesisapoptoticprocessinvolvedinembryonicdigitmorphogenesisarterialendothelialcelldifferentiationastrocytedifferentiationatrioventricularnodedevelopmentatrioventricularvalvemorphogenesisauditoryreceptorcellfatecommitmentaxonguidancebranchingmorphogenesisofanepithelialtubecalcium-ionregulatedexocytosiscardiacatriummorphogenesiscardiacchamberformationcardiacepithelialtomesenchymaltransitioncardiacleftventriclemorphogenesiscardiacmusclecellmyoblastdifferentiationcardiacmusclecellproliferationcardiacmuscletissuemorphogenesiscardiacrightatriummorphogenesiscardiacrightventricleformationcardiacseptummorphogenesiscardiacvascularsmoothmusclecelldevelopmentcardiacventriclemorphogenesiscelldifferentiationinspinalcordcellmigrationinvolvedinendocardialcushionformationcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetotumorcellcellularresponsetovascularendothelialgrowthfactorstimulusciliumassemblycollectingductdevelopmentcompartmentpatternspecificationcoronaryarterymorphogenesiscoronarysinusvalvemorphogenesiscoronaryveinmorphogenesisdeterminationofleft/rightsymmetrydistaltubuledevelopmentembryonichindlimbmorphogenesisendocardialcelldifferentiationendocardialcushionmorphogenesisendocardiumdevelopmentendocardiummorphogenesisendodermdevelopmentepidermalcellfatespecificationepithelialcellfatecommitmentepithelialcellproliferationepithelialtomesenchymaltransitionepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationforebraindevelopmentforegutmorphogenesisglomerularmesangialcelldevelopmentgrowthinvolvedinheartmorphogenesishairfolliclemorphogenesisheartdevelopmentheartloopinghearttrabeculamorphogenesishomeostasisofnumberofcellswithinatissuehumoralimmuneresponseimmuneresponseinuteroembryonicdevelopmentinflammatoryresponsetoantigenicstimulusinhibitionofneuroepithelialcelldifferentiationinterleukin-17-mediatedsignalingpathwaykeratinocytedifferentiationleft/rightaxisspecificationliverdevelopmentlungdevelopmentmesenchymalcelldevelopmentmitralvalveformationnegativeregulationofanoikisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofBMPsignalingpathwaynegativeregulationofcalciumion-dependentexocytosisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcardiacmusclehypertrophynegativeregulationofcatalyticactivitynegativeregulationofcelladhesionmoleculeproductionnegativeregulationofcellmigrationinvolvedinsproutingangiogenesisnegativeregulationofcellpopulationproliferationnegativeregulationofcellproliferationinvolvedinheartvalvemorphogenesisnegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcell-substrateadhesionnegativeregulationofcold-inducedthermogenesisnegativeregulationofendothelialcellchemotaxisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixconstituentsecretionnegativeregulationofgeneexpressionnegativeregulationofglialcellproliferationnegativeregulationofinnerearauditoryreceptorcelldifferentiationnegativeregulationofmyoblastdifferentiationnegativeregulationofmyotubedifferentiationnegativeregulationofneurogenesisnegativeregulationofoligodendrocytedifferentiationnegativeregulationofossificationnegativeregulationofosteoblastdifferentiationnegativeregulationofphotoreceptorcelldifferentiationnegativeregulationofpro-BcelldifferentiationnegativeregulationofstemcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneuraltubedevelopmentneuroendocrinecelldifferentiationneuronalstemcellpopulationmaintenanceNotchsignalinginvolvedinheartdevelopmentNotchsignalingpathwayNotchsignalingpathwayinvolvedinregulationofsecondaryheartfieldcardioblastproliferationoligodendrocytedifferentiationoutflowtractmorphogenesispericardiummorphogenesispositiveregulationofaortamorphogenesispositiveregulationofapoptoticprocessinvolvedinmorphogenesispositiveregulationofastrocytedifferentiationpositiveregulationofBMPsignalingpathwaypositiveregulationofcardiacepithelialtomesenchymaltransitionpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcelldifferentiationpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofkeratinocytedifferentiationpositiveregulationofneuroblastproliferationpositiveregulationofNotchsignalingpathwaypositiveregulationofRasproteinsignaltransductionpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionofNotchreceptortargetpositiveregulationoftranscriptionDNA-templatedpositiveregulationofviralgenomereplicationprostateglandepitheliummorphogenesisproteincatabolicprocessproteinimportintonucleuspulmonaryvalvemorphogenesisregulationofepithelialcellproliferationinvolvedinprostateglanddevelopmentregulationofextracellularmatrixassemblyregulationofsomitogenesisregulationofstemcellproliferationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetocorticosteroidresponsetolipopolysaccharideresponsetomuramyldipeptideretinalconecelldifferentiationsecretorycolumnalluminarepithelialcelldifferentiationinvolvedinprostateglandularacinusdevelopmentskeletalmusclecelldifferentiationsomaticstemcelldivisionspermatogenesissproutingangiogenesisT-helper17typeimmuneresponsetissueregenerationtranscriptionbyRNApolymeraseIItubeformationvasculogenesisinvolvedincoronaryvascularmorphogenesisvenousendothelialcelldifferentiationventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesis
3-ketoacyl-CoA thiolase, peroxisomal
87
3-ketoacyl-CoA thiolase, peroxisomal
87
9.8
106
0.1
THIKTHIKP09110P09110alpha-linolenicacidmetabolicprocessbileacidmetabolicprocessfattyacidbeta-oxidationfattyacidbeta-oxidationusingacyl-CoAoxidasephenylacetatecatabolicprocessverylong-chainfattyacidmetabolicprocess
3-hydroxy-3-methylglutaryl-coenzyme A reductase
708
3-hydroxy-3-methylglutaryl-coenzyme A reductase
600
9.8
80
0.13
HMDHHMDHP04035P04035cholesterolbiosyntheticprocesscoenzymeAmetabolicprocessisoprenoidbiosyntheticprocessnegativeregulationofamyloid-betaclearancenegativeregulationofMAPkinaseactivitynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionsterolbiosyntheticprocessvisuallearning
B-cell antigen receptor complex-associated protein beta chain
136
B-cell antigen receptor complex-associated protein beta chain
122
9.7
81
0.13
CD79BCD79BP40259P40259adaptiveimmuneresponseBcelldifferentiationBcellreceptorsignalingpathwayimmuneresponsesignaltransduction
Glutamate receptor ionotropic, kainate 5
83
Glutamate receptor ionotropic, kainate 2
96
9.7
67
0.15
GRIK5GRIK2Q63273P42260cellularresponsetoglucosestimuluschemicalsynaptictransmissionestablishmentoflocalizationincellexcitatorypostsynapticpotentialmodulationofchemicalsynaptictransmissionpositiveregulationofneuronapoptoticprocessproteinretentioninERlumenreceptorclusteringregulationofmembranepotentialregulationofsynapticvesiclefusiontopresynapticactivezonemembranesynaptictransmissionglutamatergicbehavioralfearresponsecellularcalciumionhomeostasisdetectionofcoldstimulusinvolvedinthermoceptioninhibitorypostsynapticpotentialnegativeregulationofneuronapoptoticprocessnegativeregulationofsynaptictransmissionglutamatergicneuronapoptoticprocessneuronalactionpotentialpositiveregulationofsynaptictransmissionpresynapticmodulationofchemicalsynaptictransmissionregulationofJNKcascaderegulationoflong-termneuronalsynapticplasticityregulationofshort-termneuronalsynapticplasticity
Cobalamin binding intrinsic factor
182
Cobalamin binding intrinsic factor
103
9.7
92
0.11
IFIFP27352P27352cobalaminmetabolicprocesscobalamintransportcobaltiontransport
Baculoviral IAP repeat-containing protein 2
86
Baculoviral IAP repeat-containing protein 2
86
9.8
61
0.17
BIRC2BIRC2Q13490Q13490cellsurfacereceptorsignalingpathwayI-kappaBkinase/NF-kappaBsignalingnecroptoticprocessnegativeregulationofapoptoticprocessnegativeregulationofnecroptoticprocessnegativeregulationofripoptosomeassemblyinvolvedinnecroptoticprocessNIK/NF-kappaBsignalingplacentadevelopmentpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofproteinK48-linkedubiquitinationpositiveregulationofproteinK63-linkedubiquitinationpositiveregulationofproteinmonoubiquitinationpositiveregulationofproteinubiquitinationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationregulationofapoptoticprocessregulationofcellcycleregulationofcelldifferentiationregulationofcellpopulationproliferationregulationofcysteine-typeendopeptidaseactivityregulationofinflammatoryresponseregulationofinnateimmuneresponseregulationofnecroptoticprocessregulationofNIK/NF-kappaBsignalingregulationofnucleotide-bindingoligomerizationdomaincontainingsignalingpathwayregulationofreactiveoxygenspeciesmetabolicprocessregulationofRIG-Isignalingpathwayregulationoftoll-likereceptorsignalingpathwayresponsetocAMPresponsetoethanolresponsetohypoxiatumornecrosisfactor-mediatedsignalingpathway
Growth/differentiation factor 8
375
Growth/differentiation factor 8
340
9.8
83
0.12
GDF8GDF8O08689O08689cellularresponsetodexamethasonestimulusmusclecellcellularhomeostasismyoblastmigrationinvolvedinskeletalmuscleregenerationnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofkinaseactivitynegativeregulationofmusclehypertrophynegativeregulationofmyoblastdifferentiationnegativeregulationofmyoblastproliferationnegativeregulationofproteinkinaseBsignalingnegativeregulationofsatellitecelldifferentiationnegativeregulationofskeletalmusclesatellitecellproliferationnegativeregulationofskeletalmuscletissuegrowthovulationcycleprocesspositiveregulationoflamellipodiumassemblypositiveregulationofmacrophagechemotaxispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionDNA-templatedresponsetoelectricalstimulusresponsetoestrogenresponsetoethanolresponsetogravityresponsetoheatresponsetomuscleactivityresponsetotestosteroneskeletalmuscleatrophySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Ectodysplasin-A
332
Ectodysplasin-A
332
9.8
90
0.11
EDAEDAQ92838Q92838animalorgandevelopmentcanonicalWntsignalingpathwaycelldifferentiationcell-matrixadhesioncytokine-mediatedsignalingpathwaygeneexpressionhairfollicleplacodeformationimmuneresponseodontogenesisofdentin-containingtoothpigmentationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingregulationofNIK/NF-kappaBsignalingsalivaryglandcavitationtracheaglanddevelopment
Piwi-like protein 1
577
Piwi-like protein 1
586
9.8
65
0.16
PIWL1PIWL1Q9JMB7Q9JMB7genesilencingbyRNAmeioticcellcyclenegativeregulationoftranspositionpiRNAmetabolicprocessregulationoftranslationspermatiddevelopmentspermatogenesisspermatogenesisexchangeofchromosomalproteins
Mucin-2
1088
Mucin-2
1082
9.8
89
0.11
MUC2MUC2Q02817Q02817maintenanceofgastrointestinalepithelium
Trypsin
49
Tissue factor pathway inhibitor
158
9.8
85
0.12
TRYPTFPI1P00761P10646digestionproteolysisbloodcoagulationcellularresponsetosteroidhormonestimulusnegativeregulationofbloodcoagulation
Nuclear receptor ROR-gamma
320
Nuclear receptor ROR-gamma
393
9.8
59
0.17
RORGRORGP51449P51449adiposetissuedevelopmentcellularresponsetosterolcircadianregulationofgeneexpressionlymphnodedevelopmentnegativeregulationofthymocyteapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseII"Peyerspatchdevelopment"positiveregulationofcircadianrhythmpositiveregulationoftranscriptionDNA-templatedregulationoffatcelldifferentiationregulationofglucosemetabolicprocessregulationofsteroidmetabolicprocessregulationoftranscriptionbyRNApolymeraseIIT-helper17celldifferentiationT-helpercelldifferentiationxenobioticmetabolicprocess
Growth/differentiation factor 11
406
Growth/differentiation factor 11
371
9.8
81
0.13
GDF11GDF11O95390O95390amacrinecelldifferentiationcamera-typeeyemorphogenesiscellpopulationproliferationmesodermdevelopmentmetanephrosdevelopmentnegativeregulationofamacrinecelldifferentiationnegativeregulationofcellpopulationproliferationnervoussystemdevelopmentpositiveregulationofpathway-restrictedSMADproteinphosphorylationroofofmouthdevelopmentskeletalsystemdevelopmentSMADproteinsignaltransductionspinalcordanterior/posteriorpatterningtypeBpancreaticcellmaturationuretericbuddevelopment
Endothelin-1
67
Endothelin-1
63
9.8
48
0.21
EDN1EDN1P05305P05305adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayarterysmoothmusclecontractionaxonextensionaxonogenesisinvolvedininnervationbodyfluidsecretionbranchinginvolvedinbloodvesselmorphogenesiscalciumiontransmembranetransportcalcium-mediatedsignalingcanonicalWntsignalingpathwaycardiacneuralcrestcellmigrationinvolvedinoutflowtractmorphogenesiscartilagedevelopmentcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularcalciumionhomeostasiscellularresponsetocalciumioncellularresponsetofattyacidcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetohumanchorionicgonadotropinstimuluscellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoluteinizinghormonestimuluscellularresponsetomineralocorticoidstimuluscellularresponsetoorganicsubstancecellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetotumornecrosisfactorcellularresponsetoxenobioticstimulusdorsal/ventralpatternformationembryonichearttubedevelopmentendothelinreceptorsignalingpathwayendothelinreceptorsignalingpathwayinvolvedinheartprocessepithelialfluidtransportERK1andERK2cascadeGprotein-coupledreceptorsignalingpathwayhistaminesecretionI-kappaBkinase/NF-kappaBsignalinginuteroembryonicdevelopmentinositolphosphate-mediatedsignalingleukocyteactivationmaternalprocessinvolvedinparturitionmeioticcellcycleprocessinvolvedinoocytematurationmembranedepolarizationmiddleearmorphogenesismitochondrionorganizationmulticellularorganismagingnegativeregulationofbloodcoagulationnegativeregulationofgeneexpressionnegativeregulationofhormonesecretionnegativeregulationofnitric-oxidesynthasebiosyntheticprocessnegativeregulationofproteinmetabolicprocessnegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneuralcrestcellfatecommitmentnitricoxidetransportnoradrenergicneurondifferentiationpeptidehormonesecretionpharyngealarcharterymorphogenesisphosphatidylinositol3-kinasesignalingphospholipaseD-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcardiacmusclehypertrophypositiveregulationofcationchannelactivitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellsizepositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellmigrationpositiveregulationofheartratepositiveregulationofhormonesecretionpositiveregulationofJUNkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofmitoticnucleardivisionpositiveregulationofneutrophilchemotaxispositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofodontogenesispositiveregulationofprostaglandinsecretionpositiveregulationofprostaglandin-endoperoxidesynthaseactivitypositiveregulationofrenalsodiumexcretionpositiveregulationofsarcomereorganizationpositiveregulationofsignalingreceptoractivitypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsmoothmusclecontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofurinevolumepositiveregulationofvascularassociatedsmoothmusclecellproliferationprostaglandinbiosyntheticprocessproteinkinaseAsignalingproteinkinaseCdeactivationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteinphosphorylationregulationofglucosetransmembranetransportregulationofpHregulationofsensoryperceptionofpainregulationofsystemicarterialbloodpressurebyendothelinregulationofvasoconstrictionrenalsodiumionabsorptionrespiratorygaseousexchangebyrespiratorysystemresponsetoactivityresponsetoaminoacidresponsetoamphetamineresponsetodexamethasoneresponsetoleptinresponsetolipopolysaccharideresponsetomusclestretchresponsetonicotineresponsetoozoneresponsetoprostaglandinFresponsetosaltresponsetotestosteronerhythmicexcitationsemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesensoryperceptionofpainsuperoxideaniongenerationsympatheticneuronaxonguidancethyroidglanddevelopmenttranscriptionbyRNApolymeraseIIvasoconstrictionveinsmoothmusclecontraction
Collagen alpha-1(II) chain
69
Collagen alpha-1(II) chain
69
9.8
55
0.19
CO2A1CO2A1P02458P02458anteriorheaddevelopmentcartilagecondensationcartilagedevelopmentcartilagedevelopmentinvolvedinendochondralbonemorphogenesiscellularresponsetoBMPstimuluscentralnervoussystemdevelopmentchondrocytedifferentiationcollagenfibrilorganizationembryonicskeletaljointmorphogenesisendochondralossificationextracellularmatrixorganizationextrinsicapoptoticsignalingpathwayinabsenceofligandheartmorphogenesisinnerearmorphogenesislimbbudformationnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnotochorddevelopmentoticvesicledevelopmentproteoglycanmetabolicprocessregulationofgeneexpressionroofofmouthdevelopmentsensoryperceptionofsoundskeletalsystemdevelopmenttissuehomeostasisvisualperception
Alpha-actinin-2
270
Alpha-actinin-2
862
9.8
62
0.17
ACTN2ACTN2P35609P35609actincytoskeletonorganizationactinfilamentuncappingcardiacmusclecelldevelopmentcelladhesionfocaladhesionassemblymicrospikeassemblymusclecelldevelopmentnegativeregulationofpotassiumiontransmembranetransporteractivitynegativeregulationofpotassiumiontransportnegativeregulationofproteinlocalizationtocellsurfacephospholipaseC-activatingangiotensin-activatedsignalingpathwaypositiveregulationofcationchannelactivitypositiveregulationofendocyticrecyclingpositiveregulationofpotassiumiontransmembranetransporteractivitypositiveregulationofpotassiumiontransportproteinlocalizationtoplasmamembraneregulationofapoptoticprocessregulationofmembranepotentialsarcomereorganization
Rhodopsin
140
Guanine nucleotide-binding protein G(t) subunit alpha-3
351
9.8
65
0.16
OPSDGNAT3P02699P0C7Q4absorptionofvisiblelightcellularresponsetolightstimulusdetectionoftemperaturestimulusinvolvedinthermoceptionGprotein-coupledreceptorsignalingpathwayphotoreceptorcellmaintenancephototransductionphototransductionvisiblelightproteinphosphorylationresponsetolightstimulusretinadevelopmentincamera-typeeyerhodopsinmediatedsignalingpathwaythermotaxisvisualperceptionadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaydetectionofchemicalstimulusinvolvedinsensoryperceptionofbittertastesensoryperceptionofsweettastesensoryperceptionofumamitaste
Rhodopsin
140
Guanine nucleotide-binding protein G(t) subunit alpha-1
347
9.8
70
0.15
OPSDGNAT1P02699P04695absorptionofvisiblelightcellularresponsetolightstimulusdetectionoftemperaturestimulusinvolvedinthermoceptionGprotein-coupledreceptorsignalingpathwayphotoreceptorcellmaintenancephototransductionphototransductionvisiblelightproteinphosphorylationresponsetolightstimulusretinadevelopmentincamera-typeeyerhodopsinmediatedsignalingpathwaythermotaxisvisualperceptionadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellpopulationproliferationcellularresponsetoelectricalstimulusdetectionoflightstimulusinvolvedinvisualperceptioneyephotoreceptorcelldevelopmentGprotein-coupledadenosinereceptorsignalingpathwaynegativeregulationofcyclic-nucleotidephosphodiesteraseactivitysensoryperceptionofumamitaste
Insulin
95
Insulin
43
9.8
58
0.18
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
Prosaposin
201
Prosaposin
201
9.9
76
0.13
SAPSAPP07602P07602adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayepithelialcelldifferentiationinvolvedinprostateglanddevelopmentgangliosideGM1transporttomembranelysosomaltransportpositiveregulationofbeta-galactosidaseactivityprostateglandgrowthregulationofautophagyregulationoflipidmetabolicprocesssphingolipidmetabolicprocess
Endothelin receptor type B
255
Endothelin-3
111
9.9
87
0.12
EDNRBEDN3P24530P14138agingaldosteronemetabolicprocesscalciumiontransmembranetransportcalcium-mediatedsignalingcanonicalWntsignalingpathwaycellsurfacereceptorsignalingpathwaycellularresponsetolipopolysaccharidecGMP-mediatedsignalingdevelopmentalpigmentationendothelinreceptorsignalingpathwayentericnervoussystemdevelopmententericsmoothmusclecelldifferentiationepithelialfluidtransportestablishmentofendothelialbarriergeneexpressionheparinmetabolicprocessI-kappaBkinase/NF-kappaBsignalingmacrophagechemotaxismelanocytedifferentiationnegativeregulationofadenylatecyclaseactivitynegativeregulationofapoptoticprocessnegativeregulationofneuronmaturationnegativeregulationofproteinmetabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentneuralcrestcellmigrationneuroblastmigrationperipheralnervoussystemdevelopmentpharynxdevelopmentphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypodocytedifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofpenileerectionpositiveregulationofproteinphosphorylationpositiveregulationofrenalsodiumexcretionpositiveregulationofurinevolumeposteriormidgutdevelopmentproteintransmembranetransportregulationofepithelialcellproliferationregulationoffevergenerationregulationofheartrateregulationofpHregulationofsensoryperceptionofpainrenalalbuminabsorptionrenalsodiumexcretionrenalsodiumionabsorptionreninsecretionintobloodstreamresponsetoendothelinresponsetoorganiccycliccompoundresponsetopainresponsetosodiumphosphatesensoryperceptionofpainvasoconstrictionvasodilationveinsmoothmusclecontractionaxonextensionaxonguidancebloodcirculationcellpopulationproliferationcell-cellsignalingcellularcalciumionhomeostasiscellularmagnesiumionhomeostasisestablishmentoflocalizationincellinositolphosphate-mediatedsignalingneutrophilchemotaxispeptidehormonesecretionpositiveregulationofcelldifferentiationpositiveregulationofheartratepositiveregulationofhormonesecretionpositiveregulationofleukocytechemotaxispositiveregulationofMAPkinaseactivitypositiveregulationofmitoticnucleardivisionpositiveregulationofpotassiumiontransmembranetransportpositiveregulationofprostaglandin-endoperoxidesynthaseactivitypotassiumiontransmembranetransportregulationofdevelopmentalpigmentationregulationofgeneexpressionregulationofsystemicarterialbloodpressurebyendothelinregulationofvasoconstrictionsignaltransduction
Bone morphogenetic protein 10
388
Bone morphogenetic protein 10
423
9.9
87
0.12
BMP10BMP10O95393O95393activinreceptorsignalingpathwayadultheartdevelopmentatrialcardiacmuscletissuemorphogenesisBMPsignalingpathwaycardiacmusclecellproliferationcelladhesionhearttrabeculaformationkidneydevelopmentnegativeregulationofcardiacmusclehypertrophynegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofendothelialcellmigrationpathway-restrictedSMADproteinphosphorylationpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcardiacmusclehypertrophypositiveregulationofcartilagedevelopmentpositiveregulationofcellproliferationinvolvedinheartmorphogenesispositiveregulationofgeneexpressionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofsarcomereorganizationpositiveregulationoftranscriptionDNA-templatedregulationofcardiacmusclecontractionregulationofcardiacmusclehypertrophyinresponsetostresssarcomereorganizationSMADproteinsignaltransductionventricularcardiacmusclecelldevelopmentventricularcardiacmuscletissuemorphogenesis
DNA (cytosine-5)-methyltransferase 3A
537
DNA (cytosine-5)-methyltransferase 3A
497
9.9
89
0.11
DNM3ADNM3AQ9Y6K1Q9Y6K1agingC-5methylationofcytosinecellularresponsetoaminoacidstimuluscellularresponsetobisphenolAcellularresponsetoethanolcellularresponsetohypoxiaDNAmethylationDNAmethylationinvolvedinembryodevelopmentDNAmethylationinvolvedingametegenerationDNAmethylationoncytosineDNAmethylation-dependentheterochromatinassemblyhepatocyteapoptoticprocessmitoticcellcyclenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneurondifferentiationpositiveregulationofcelldeathregulationofgeneexpressionbygenomicimprintingresponsetococaineresponsetoestradiolresponsetoionizingradiationresponsetoleadionresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulusspermatogenesis
Tyrosyl-DNA phosphodiesterase 2
352
Tyrosyl-DNA phosphodiesterase 2
137
9.9
51
0.2
TYDP2TYDP2Q9JJX7Q9JJX7double-strandbreakrepairneurondevelopment
Dehydrodolichyl diphosphate synthase complex subunit DHDDS
191
Dehydrodolichyl diphosphate synthase complex subunit NUS1
208
9.8
75
0.14
DHDDSNGBRQ86SQ9Q96E22dolichyldiphosphatebiosyntheticprocesspolyprenolbiosyntheticprocessangiogenesiscelldifferentiationcholesterolhomeostasisdolicholbiosyntheticprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofnitric-oxidesynthaseactivityproteinglycosylationproteinmannosylationregulationofintracellularcholesteroltransportvascularendothelialgrowthfactorsignalingpathway
Neurogenic locus notch homolog protein 1
1549
Neurogenic locus notch homolog protein 1
1536
9.8
87
0.12
NOTC1NOTC1P46531P46531animalorganregenerationaorticvalvemorphogenesisapoptoticprocessinvolvedinembryonicdigitmorphogenesisarterialendothelialcelldifferentiationastrocytedifferentiationatrioventricularnodedevelopmentatrioventricularvalvemorphogenesisauditoryreceptorcellfatecommitmentaxonguidancebranchingmorphogenesisofanepithelialtubecalcium-ionregulatedexocytosiscardiacatriummorphogenesiscardiacchamberformationcardiacepithelialtomesenchymaltransitioncardiacleftventriclemorphogenesiscardiacmusclecellmyoblastdifferentiationcardiacmusclecellproliferationcardiacmuscletissuemorphogenesiscardiacrightatriummorphogenesiscardiacrightventricleformationcardiacseptummorphogenesiscardiacvascularsmoothmusclecelldevelopmentcardiacventriclemorphogenesiscelldifferentiationinspinalcordcellmigrationinvolvedinendocardialcushionformationcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetotumorcellcellularresponsetovascularendothelialgrowthfactorstimulusciliumassemblycollectingductdevelopmentcompartmentpatternspecificationcoronaryarterymorphogenesiscoronarysinusvalvemorphogenesiscoronaryveinmorphogenesisdeterminationofleft/rightsymmetrydistaltubuledevelopmentembryonichindlimbmorphogenesisendocardialcelldifferentiationendocardialcushionmorphogenesisendocardiumdevelopmentendocardiummorphogenesisendodermdevelopmentepidermalcellfatespecificationepithelialcellfatecommitmentepithelialcellproliferationepithelialtomesenchymaltransitionepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationforebraindevelopmentforegutmorphogenesisglomerularmesangialcelldevelopmentgrowthinvolvedinheartmorphogenesishairfolliclemorphogenesisheartdevelopmentheartloopinghearttrabeculamorphogenesishomeostasisofnumberofcellswithinatissuehumoralimmuneresponseimmuneresponseinuteroembryonicdevelopmentinflammatoryresponsetoantigenicstimulusinhibitionofneuroepithelialcelldifferentiationinterleukin-17-mediatedsignalingpathwaykeratinocytedifferentiationleft/rightaxisspecificationliverdevelopmentlungdevelopmentmesenchymalcelldevelopmentmitralvalveformationnegativeregulationofanoikisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofBMPsignalingpathwaynegativeregulationofcalciumion-dependentexocytosisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcardiacmusclehypertrophynegativeregulationofcatalyticactivitynegativeregulationofcelladhesionmoleculeproductionnegativeregulationofcellmigrationinvolvedinsproutingangiogenesisnegativeregulationofcellpopulationproliferationnegativeregulationofcellproliferationinvolvedinheartvalvemorphogenesisnegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcell-substrateadhesionnegativeregulationofcold-inducedthermogenesisnegativeregulationofendothelialcellchemotaxisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixconstituentsecretionnegativeregulationofgeneexpressionnegativeregulationofglialcellproliferationnegativeregulationofinnerearauditoryreceptorcelldifferentiationnegativeregulationofmyoblastdifferentiationnegativeregulationofmyotubedifferentiationnegativeregulationofneurogenesisnegativeregulationofoligodendrocytedifferentiationnegativeregulationofossificationnegativeregulationofosteoblastdifferentiationnegativeregulationofphotoreceptorcelldifferentiationnegativeregulationofpro-BcelldifferentiationnegativeregulationofstemcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneuraltubedevelopmentneuroendocrinecelldifferentiationneuronalstemcellpopulationmaintenanceNotchsignalinginvolvedinheartdevelopmentNotchsignalingpathwayNotchsignalingpathwayinvolvedinregulationofsecondaryheartfieldcardioblastproliferationoligodendrocytedifferentiationoutflowtractmorphogenesispericardiummorphogenesispositiveregulationofaortamorphogenesispositiveregulationofapoptoticprocessinvolvedinmorphogenesispositiveregulationofastrocytedifferentiationpositiveregulationofBMPsignalingpathwaypositiveregulationofcardiacepithelialtomesenchymaltransitionpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcelldifferentiationpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofkeratinocytedifferentiationpositiveregulationofneuroblastproliferationpositiveregulationofNotchsignalingpathwaypositiveregulationofRasproteinsignaltransductionpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionofNotchreceptortargetpositiveregulationoftranscriptionDNA-templatedpositiveregulationofviralgenomereplicationprostateglandepitheliummorphogenesisproteincatabolicprocessproteinimportintonucleuspulmonaryvalvemorphogenesisregulationofepithelialcellproliferationinvolvedinprostateglanddevelopmentregulationofextracellularmatrixassemblyregulationofsomitogenesisregulationofstemcellproliferationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetocorticosteroidresponsetolipopolysaccharideresponsetomuramyldipeptideretinalconecelldifferentiationsecretorycolumnalluminarepithelialcelldifferentiationinvolvedinprostateglandularacinusdevelopmentskeletalmusclecelldifferentiationsomaticstemcelldivisionspermatogenesissproutingangiogenesisT-helper17typeimmuneresponsetissueregenerationtranscriptionbyRNApolymeraseIItubeformationvasculogenesisinvolvedincoronaryvascularmorphogenesisvenousendothelialcelldifferentiationventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesis
WD repeat-containing protein 48
366
Ubiquitin carboxyl-terminal hydrolase 46
233
9.8
67
0.15
WDR48UBP46Q8TAF3P62068cellularresponsetoDNAdamagestimulusdouble-strandbreakrepairviahomologousrecombinationembryonicorgandevelopmenthomeostasisofnumberofcellsmulticellularorganismgrowthpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofepithelialcellproliferationproteindeubiquitinationregulationofproteinmonoubiquitinationseminiferoustubuledevelopmentsinglefertilizationskeletalsystemmorphogenesisskindevelopmentspermatogenesisadultfeedingbehaviorbehavioralfearresponsebehavioralresponsetoethanolregulationofsynaptictransmissionGABAergicrightingreflexubiquitin-dependentproteincatabolicprocess
Urokinase plasminogen activator surface receptor
93
Urokinase plasminogen activator surface receptor
39
9.8
55
0.19
UPARUPARQ03405Q03405bloodcoagulationchemotaxisnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaynegativeregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofDNAbindingpositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofhomotypiccell-celladhesionpositiveregulationofproteinphosphorylationpositiveregulationofreleaseofcytochromecfrommitochondriaregulationofcelladhesionregulationoffibrinolysisregulationofplasminogenactivationregulationofproteolysissignaltransductionurokinaseplasminogenactivatorsignalingpathway
Prostasin
86
Pancreatic trypsin inhibitor
73
9.8
85
0.12
PRSS8BPT1Q16651P00974positiveregulationofsodiumiontransportproteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Serine/threonine-protein kinase/endoribonuclease IRE1
605
Serine/threonine-protein kinase/endoribonuclease IRE1
605
9.8
60
0.17
ERN1ERN1O75460O75460cellularresponsetoglucosestimuluscellularresponsetohydrogenperoxidecellularresponsetounfoldedproteincellularresponsetovascularendothelialgrowthfactorstimulusendothelialcellproliferationinsulinmetabolicprocessintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressIRE1-mediatedunfoldedproteinresponsemRNAcatabolicprocessmRNAcleavagemRNAcleavageinvolvedinmRNAprocessingmRNAsplicingviaendonucleolyticcleavageandligationpeptidyl-serineautophosphorylationpeptidyl-serinetrans-autophosphorylationpositiveregulationofendoplasmicreticulumunfoldedproteinresponsepositiveregulationofJUNkinaseactivitypositiveregulationofRNAsplicingpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinautophosphorylationproteinphosphorylationregulationofmacroautophagyresponsetoendoplasmicreticulumstress
Receptor activity-modifying protein 2
99
Receptor activity-modifying protein 2
99
9.8
64
0.16
RAMP2RAMP2O60895O60895adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadherensjunctionassemblyadrenomedullinreceptorsignalingpathwayamylinreceptorsignalingpathwayangiogenesisbasementmembraneassemblybicellulartightjunctionassemblycalciumiontransportcellularresponsetohormonestimuluscellularresponsetovascularendothelialgrowthfactorstimulusGprotein-coupledreceptorsignalingpathwayheartdevelopmentintracellularproteintransportnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofvascularpermeabilitypositiveregulationofangiogenesispositiveregulationofgeneexpressionpositiveregulationofvasculogenesisproteinlocalizationtoplasmamembraneproteintransportreceptorinternalizationregulationofbloodpressureregulationofGprotein-coupledreceptorsignalingpathwaysproutingangiogenesisvascularassociatedsmoothmusclecelldevelopmentvasculogenesis
Kelch-like ECH-associated protein 1
434
Kelch-like ECH-associated protein 1
406
9.8
53
0.19
KEAP1KEAP1Q14145Q14145cellularresponsetointerleukin-4cellularresponsetooxidativestresscytoplasmicsequesteringoftranscriptionfactorinuteroembryonicdevelopmentnegativeregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteinubiquitinationregulationofautophagyregulationofepidermalcelldifferentiationubiquitin-dependentproteincatabolicprocess
Tyrosyl-DNA phosphodiesterase 2
311
Tyrosyl-DNA phosphodiesterase 2
137
9.8
68
0.15
TYDP2TYDP2O95551O95551cellsurfacereceptorsignalingpathwaydouble-strandbreakrepairneurondevelopment
Ferritin
180
Ferritin
180
9.8
76
0.13
Q6NS36Q6NS36Q6NS36Q6NS36cellularironionhomeostasisironiontransport
Estrogen receptor
237
Estrogen receptor
237
9.2
73
0.15
ESR1ESR1P03372P03372androgenmetabolicprocessantralovarianfolliclegrowthcellularresponsetoestradiolstimuluscellularresponsetoestrogenstimuluschromatinremodelingepithelialcelldevelopmentepithelialcellproliferationinvolvedinmammaryglandductelongationfibroblastproliferationintracellularestrogenreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaymalegonaddevelopmentmammaryglandalveolusdevelopmentmammaryglandbranchinginvolvedinpregnancynegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofgeneexpressionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofmiRNAmaturationnegativeregulationoftranscriptionbyRNApolymeraseIIphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoffibroblastproliferationpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofphospholipaseCactivitypositiveregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprostateepithelialcordarborizationinvolvedinprostateglandularacinusmorphogenesisprostateepithelialcordelongationproteinlocalizationtochromatinregulationofbranchinginvolvedinprostateglandmorphogenesisregulationofepithelialcellapoptoticprocessregulationofinflammatoryresponseregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetoestradiolresponsetoestrogensignaltransductionstemcelldifferentiationtranscriptionbyRNApolymeraseIIuterusdevelopmentvaginadevelopment
Beta-arrestin-2
244
Beta-arrestin-2
244
9.0
65
0.17
ARRB2ARRB2P29067P29067adultwalkingbehaviorbraindevelopmentcellchemotaxisdesensitizationofGprotein-coupledreceptorsignalingpathwaybyarrestindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainendocytosisfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorinternalizationGprotein-coupledreceptorsignalingpathwaynegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofGTPaseactivitynegativeregulationofinterleukin-1betaproductionnegativeregulationofinterleukin-12productionnegativeregulationofinterleukin-6productionnegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofneuronapoptoticprocessnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofproteinphosphorylationnegativeregulationofproteinubiquitinationnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftoll-likereceptorsignalingpathwaynegativeregulationoftumornecrosisfactorproductionpositiveregulationofcalciumiontransportpositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofDNAbiosyntheticprocesspositiveregulationofepithelialcellapoptoticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofreceptorinternalizationpositiveregulationofsynaptictransmissiondopaminergicproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteintransportproteinubiquitinationreceptorinternalizationregulationofGprotein-coupledreceptorsignalingpathwayregulationofproteinphosphorylationtranscriptionbyRNApolymeraseIItransforminggrowthfactorbetareceptorsignalingpathway
Brain-derived neurotrophic factor
196
Neurotrophin-3
248
9.0
87
0.13
BDNFNTF3P23560P20783axonguidancebrain-derivedneurotrophicfactorreceptorsignalingpathwaycollateralsproutingmemorymodulationofchemicalsynaptictransmissionnegativeregulationofapoptoticsignalingpathwaynegativeregulationofmyotubedifferentiationnegativeregulationofneuronapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwaynervoussystemdevelopmentneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofbrain-derivedneurotrophicfactorreceptorsignalingpathwaypositiveregulationofcollateralsproutingpositiveregulationofneuronprojectiondevelopmentpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofreceptorbindingpositiveregulationofsynapseassemblyregulationofneurondifferentiationregulationofproteinlocalizationtocellsurfacesynapseassemblytransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofGTPaseactivityactivationofproteinkinaseBactivitycell-cellsignalinginductionofpositivechemotaxisnegativeregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofactincytoskeletonreorganizationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofreceptorinternalizationregulationofapoptoticprocesssignaltransduction
Trypsin-3
105
Protein AMBP
296
9.3
96
0.11
TRY3AMBPP35030P02760antimicrobialhumoralresponsedigestionendothelialcellmigrationproteolysiszymogenactivationcelladhesioncellularoxidantdetoxificationcellularresponsetoreactiveoxygenspeciescytochromecmetabolicprocessfemalepregnancyhemecatabolicprocesshemoglobinmetabolicprocessnegativeregulationofimmuneresponsenegativeregulationofJNKcascadeproteincatabolicprocess
Spindle and kinetochore-associated protein 1
10
Spindle and kinetochore-associated protein 1
10
9.3
66
0.16
SKA1SKA1Q96BD8Q96BD8celldivisionchromosomesegregationmitoticcellcycleregulationofmicrotubulepolymerizationordepolymerization
Suppressor of cytokine signaling 4
393
Elongin-C
112
9.0
nan
nan
SOCS4ELOCQ8WXH5Q15369intracellularsignaltransductionnegativeregulationofepidermalgrowthfactor-activatedreceptoractivityphosphatidylinositolphosphatebiosyntheticprocesspositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteinubiquitinationregulationofgrowthregulationoftranscriptionbyRNApolymeraseIItranscriptioninitiationfromRNApolymeraseIIpromoterubiquitin-dependentproteincatabolicprocess
C-C motif chemokine 5
57
C-C motif chemokine 5
57
9.0
61
0.18
CCL5CCL5P13501P13501activationofphospholipaseDactivitycalciumiontransportcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetoviruschemokine-mediatedsignalingpathwaychemotaxisdendriticcellchemotaxiseosinophilchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwayinflammatoryresponseleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofinnateimmuneresponsepositiveregulationofmacrophagechemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftranslationalinitiationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofviralgenomereplicationproteinkinaseBsignalingregulationofchronicinflammatoryresponseregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetotoxicsubstanceresponsetovirus
Suppressor of tumorigenicity 14 protein
641
Kunitz-type protease inhibitor 1
259
9.0
100
0.11
ST14SPIT1Q9Y5Y6O43278epithelialcellmorphogenesisinvolvedinplacentalbranchingkeratinocytedifferentiationneuraltubeclosureproteincatabolicprocessproteolysisbranchinginvolvedinlabyrinthinelayermorphogenesiscellularresponsetoBMPstimulusepidermisdevelopmentepitheliumdevelopmentextracellularmatrixorganizationnegativeregulationofneuralprecursorcellproliferationplacentabloodvesseldevelopmentpositiveregulationofglialcelldifferentiation
Growth/differentiation factor 8
313
Growth/differentiation factor 8
339
9.0
58
0.19
GDF8GDF8O14793O14793cellularresponsetodexamethasonestimulusmusclecellcellularhomeostasismuscleorgandevelopmentmyoblastmigrationinvolvedinskeletalmuscleregenerationnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofkinaseactivitynegativeregulationofmusclehypertrophynegativeregulationofmyoblastdifferentiationnegativeregulationofmyoblastproliferationnegativeregulationofproteinkinaseBsignalingnegativeregulationofsatellitecelldifferentiationnegativeregulationofskeletalmusclesatellitecellproliferationnegativeregulationofskeletalmuscletissuegrowthovulationcycleprocesspositiveregulationoflamellipodiumassemblypositiveregulationofmacrophagechemotaxispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionDNA-templatedresponsetoelectricalstimulusresponsetoestrogenresponsetoethanolresponsetogravityresponsetoheatresponsetomuscleactivityresponsetotestosteroneskeletalmuscleatrophySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Complement C3
873
Complement C3
1511
9.0
64
0.17
CO3CO3P01024P01024amyloid-betaclearancecellsurfacereceptorsignalingpathwayinvolvedincell-cellsignalingcomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitycomplement-mediatedsynapsepruningfattyacidmetabolicprocessGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseneuronremodelingopsonizationoviductepitheliumdevelopmentpositiveregulationofactivationofmembraneattackcomplexpositiveregulationofangiogenesispositiveregulationofapoptoticcellclearancepositiveregulationofapoptoticprocessinanotherorganismpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofglucosetransmembranetransportpositiveregulationofimmuneresponsepositiveregulationoflipidstoragepositiveregulationofopsonizationpositiveregulationofphagocytosispositiveregulationofphagocytosisengulfmentpositiveregulationofproteinphosphorylationpositiveregulationofreceptor-mediatedendocytosispositiveregulationoftypeIIahypersensitivitypositiveregulationofvascularendothelialgrowthfactorproductionproteolysisregulationofcomplementactivationregulationofcomplementactivationalternativepathwayregulationoftriglyceridebiosyntheticprocessresponsetobacteriumsignaltransductionvertebrateeye-specificpatterning
Serine protease 1
220
Serine protease inhibitor Kazal-type 1
16
9.0
86
0.13
TRY1ISK1P00760P00998digestionproteolysis
Nucleotide triphosphate diphosphatase NUDT15
59
Nucleotide triphosphate diphosphatase NUDT15
23
9.3
74
0.14
NUD15NUD15Q9NV35Q9NV35dGTPcatabolicprocessDNAprotectionmitoticcellcyclenucleobase-containingsmallmoleculemetabolicprocessnucleosidephosphatecatabolicprocesspurinenucleotidecatabolicprocessregulationofproteasomalproteincatabolicprocessresponsetoreactiveoxygenspeciesxenobioticcatabolicprocess
Proprotein convertase subtilisin/kexin type 9
375
Low-density lipoprotein receptor
329
9.4
67
0.16
PCSK9LDLRQ8NBP7P01130apoptoticprocesscellularresponsetoinsulinstimuluscellularresponsetostarvationcholesterolhomeostasischolesterolmetabolicprocesskidneydevelopmentlipoproteinmetabolicprocessliverdevelopmentlow-densitylipoproteinparticlereceptorcatabolicprocesslysosomaltransportnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationoflow-densitylipoproteinparticlereceptorbindingnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofreceptorinternalizationnegativeregulationofreceptorrecyclingnegativeregulationofreceptor-mediatedendocytosisinvolvedincholesteroltransportnegativeregulationofsodiumiontransmembranetransporteractivityneurogenesisneurondifferentiationphospholipidmetabolicprocesspositiveregulationoflow-densitylipoproteinparticlereceptorcatabolicprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofreceptorinternalizationproteinautoprocessingregulationofneuronapoptoticprocessregulationofsignalingreceptoractivitytriglyceridemetabolicprocessamyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessarterymorphogenesiscellularresponsetofattyacidcellularresponsetolow-densitylipoproteinparticlestimuluscholesterolimportcholesteroltransportendocytosishigh-densitylipoproteinparticleclearanceintestinalcholesterolabsorptionlipidmetabolicprocesslipoproteincatabolicprocesslong-termmemorylow-densitylipoproteinparticleclearancenegativeregulationofamyloidfibrilformationnegativeregulationofastrocyteactivationnegativeregulationofgeneexpressionnegativeregulationofmicroglialcellactivationnegativeregulationofproteinmetabolicprocessphagocytosisphospholipidtransportplasmalipoproteinparticleclearancepositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationoflysosomalproteincatabolicprocesspositiveregulationoftriglyceridebiosyntheticprocessreceptor-mediatedendocytosisreceptor-mediatedendocytosisinvolvedincholesteroltransportregulationofcholesterolmetabolicprocessregulationofphosphatidylcholinecatabolicprocessregulationofproteinmetabolicprocessresponsetocaloricrestriction
Kunitz-type protease inhibitor 1
101
Suppressor of tumorigenicity 14 protein
641
9.4
88
0.12
H3BR01ST14H3BR01Q9Y5Y6epithelialcellmorphogenesisinvolvedinplacentalbranchingkeratinocytedifferentiationneuraltubeclosureproteincatabolicprocessproteolysis
Protein diaphanous homolog 1
445
Protein diaphanous homolog 1
428
9.4
63
0.17
DIAP1DIAP1O08808O08808actincytoskeletonorganizationactinfilamentpolymerizationbraindevelopmentcellularresponsetohistaminecytoskeletonorganizationneuronprojectiondevelopmentpositiveregulationofcellmigrationproteinlocalizationtomicrotubuleregulationofcellshaperegulationofcytoskeletonorganizationregulationofmicrotubule-basedprocessregulationofreleaseofsequesteredcalciumionintocytosolsensoryperceptionofsound
Membrane cofactor protein
64
Membrane cofactor protein
64
9.1
79
0.14
MCPMCPP15529P15529adaptiveimmuneresponsecomplementactivationclassicalpathwayinnateimmuneresponsenegativeregulationofcomplementactivationclassicalpathwaynegativeregulationofgeneexpressionpositiveregulationofgeneexpressionpositiveregulationofinterleukin-10productionpositiveregulationofmemoryTcelldifferentiationpositiveregulationofregulatoryTcelldifferentiationpositiveregulationofTcellproliferationpositiveregulationoftransforminggrowthfactorbetaproductionregulationofNotchsignalingpathwaysequesteringofextracellularligandfromreceptorsinglefertilizationTcellmediatedimmunity
A disintegrin and metalloproteinase with thrombospondin motifs 5
371
A disintegrin and metalloproteinase with thrombospondin motifs 5
394
9.1
85
0.13
ATS5ATS5Q9UNA0Q9UNA0defenseresponsetobacteriumextracellularmatrixdisassemblyextracellularmatrixorganizationmyoblastfusionnegativeregulationofcold-inducedthermogenesisproteolysistootheruption
Artemin
187
Artemin
154
9.1
62
0.18
ARTNARTNQ5T4W7Q5T4W7axonguidanceinductionofpositivechemotaxislymphocytemigrationintolymphoidorgansneuroblastproliferationperipheralnervoussystemdevelopment"Peyerspatchmorphogenesis"signaltransduction
SPARC
130
SPARC
95
9.1
76
0.15
SPRCSPRCP09486P09486anatomicalstructuredevelopmentnegativeregulationofangiogenesisnegativeregulationofendothelialcellproliferationpositiveregulationofendothelialcellmigrationregulationofcellmorphogenesis
Kallikrein-7
239
Kallikrein-7
239
9.0
78
0.14
KLK7KLK7P49862P49862epidermisdevelopmentextracellularmatrixdisassemblypositiveregulationofantibacterialpeptideproductionproteolysis
E3 ubiquitin-protein ligase TRIM7
378
E3 ubiquitin-protein ligase TRIM7
455
9.0
71
0.16
TRIM7TRIM7Q9C029Q9C029proteinubiquitination
Fractalkine
74
Fractalkine
58
9.1
58
0.19
X3CL1X3CL1P78423P78423agingangiogenesisinvolvedinwoundhealingautocrinesignalingcelladhesioncellchemotaxiscell-celladhesioncell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytokine-mediatedsignalingpathwaydefenseresponseeosinophilchemotaxisextrinsicapoptoticsignalingpathwayinabsenceofligandGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseintegrinactivationleukocyteadhesiveactivationleukocytechemotaxisleukocytemigrationinvolvedininflammatoryresponselymphocytechemotaxismicroglialcellactivationmicroglialcellproliferationmonocytechemotaxisnegativeregulationofapoptoticprocessnegativeregulationofapoptoticsignalingpathwaynegativeregulationofcellmigrationnegativeregulationofcell-substrateadhesionnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofglutamatereceptorsignalingpathwaynegativeregulationofhippocampalneuronapoptoticprocessnegativeregulationofinterleukin-1alphaproductionnegativeregulationofinterleukin-1betaproductionnegativeregulationofinterleukin-6productionnegativeregulationofmicroglialcellactivationnegativeregulationofneuronmigrationnegativeregulationoftumornecrosisfactorproductionneuroncellularhomeostasisneuronremodelingneutrophilchemotaxispositivechemotaxispositiveregulationofactinfilamentbundleassemblypositiveregulationofcalcium-independentcell-celladhesionpositiveregulationofcellpopulationproliferationpositiveregulationofcell-matrixadhesionpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofI-kappaBphosphorylationpositiveregulationofinflammatoryresponsepositiveregulationofMAPKcascadepositiveregulationofmicroglialcellmigrationpositiveregulationofneuroblastproliferationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftransforminggrowthfactorbeta1productionregulationoflipopolysaccharide-mediatedsignalingpathwayregulationofneurogenesisregulationofsynapticplasticityresponsetoischemiasynapsepruning
Fibrinogen beta chain
110
Fibrinogen alpha chain
64
9.1
87
0.13
FIBBFIBAP02675P02671adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumionbloodcoagulationcommonpathwaynegativeregulationofbloodcoagulationcommonpathway
Integrin beta-2
62
Integrin beta-2
447
9.1
77
0.14
ITB2ITB2P05107P05107amyloid-betaclearanceapoptoticprocesscelladhesioncelladhesionmediatedbyintegrincellmigrationcell-celladhesioncell-celladhesionviaplasma-membraneadhesionmoleculescell-cellsignalingcell-matrixadhesioncellularresponsetolow-densitylipoproteinparticlestimulusendodermalcelldifferentiationheterotypiccell-celladhesioninflammatoryresponseintegrin-mediatedsignalingpathwayleukocytecell-celladhesionmicroglialcellactivationnegativeregulationofdopaminemetabolicprocessneutrophilchemotaxisneutrophilmigrationphagocytosisengulfmentpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofneurondeathpositiveregulationofneutrophildegranulationpositiveregulationofprostaglandin-Esynthaseactivitypositiveregulationofproteintargetingtomembranepositiveregulationofsuperoxideaniongenerationreceptorclusteringreceptorinternalizationreceptor-mediatedendocytosisregulationofcellshaperegulationofpeptidyl-tyrosinephosphorylation
Defensin beta 4A
53
Defensin beta 4A
53
9.1
90
0.12
DFB4ADFB4AO15263O15263antifungalinnateimmuneresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellchemotaxischemotaxisdefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponsekillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Copper transport protein ATOX1
15
Copper-transporting ATPase 1
19
9.1
61
0.18
ATOX1ATP7AO00244Q04656cellularcopperionhomeostasiscopperiontransportresponsetooxidativestressbloodvesseldevelopmentbloodvesselremodelingcartilagedevelopmentcatecholaminemetabolicprocesscellularresponsetoaminoacidstimuluscellularresponsetoantibioticcellularresponsetocadmiumioncellularresponsetocobaltioncellularresponsetocopperioncellularresponsetohypoxiacellularresponsetoironioncellularresponsetoleadioncellularresponsetoplatelet-derivedgrowthfactorstimuluscentralnervoussystemneurondevelopmentcerebellarPurkinjecelldifferentiationcollagenfibrilorganizationcopperionexportcopperionhomeostasiscopperionimportdetoxificationofcopperiondopaminemetabolicprocesselasticfiberassemblyelastinbiosyntheticprocessepinephrinemetabolicprocessextracellularmatrixorganizationfemalepregnancyhairfolliclemorphogenesisinuteroembryonicdevelopmentlactationliverdevelopmentlocomotorybehaviorlungalveolusdevelopmentmitochondrionorganizationnegativeregulationofironiontransmembranetransportneuronprojectionmorphogenesisnorepinephrinemetabolicprocesspeptidyl-lysinemodificationpigmentationpositiveregulationofcatalyticactivitypositiveregulationofcellsizepositiveregulationofepithelialcellproliferationpositiveregulationoflamellipodiumassemblypositiveregulationofmelaninbiosyntheticprocesspositiveregulationofresponsetowoundingpositiveregulationoftyrosinaseactivitypositiveregulationofvascularassociatedsmoothmusclecellmigrationpyramidalneurondevelopmentregulationofcytochrome-coxidaseactivityregulationofgeneexpressionregulationofoxidativephosphorylationremovalofsuperoxideradicalsresponsetoiron(III)ionresponsetomanganeseionresponsetozincionserotoninmetabolicprocessskindevelopmentT-helpercelldifferentiationtryptophanmetabolicprocess
TNF receptor-associated factor 5
98
TNF receptor-associated factor 6
85
9.1
60
0.18
TRAF5TRAF6O00463Q9Y4K3apoptoticprocessinterleukin-17-mediatedsignalingpathwaymRNAstabilizationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofJNKcascadepositiveregulationofNF-kappaBtranscriptionfactoractivityproteinK63-linkedubiquitinationregulationofapoptoticprocessregulationofI-kappaBkinase/NF-kappaBsignalingsignaltransductionsignaltransductioninvolvedinregulationofgeneexpressiontumornecrosisfactor-mediatedsignalingpathwayactivationofNF-kappaB-inducingkinaseactivityactivationofproteinkinaseactivityantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIboneresorptioncelldevelopmentcellularresponsetocytokinestimuluscellularresponsetoDNAdamagestimuluscellularresponsetolipopolysaccharidecytoplasmicpatternrecognitionreceptorsignalingpathwayFc-epsilonreceptorsignalingpathwayI-kappaBkinase/NF-kappaBsignalinginuteroembryonicdevelopmentinterleukin-1-mediatedsignalingpathwayMyD88-dependenttoll-likereceptorsignalingpathwaymyeloiddendriticcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneuraltubeclosureodontogenesisofdentin-containingtoothossificationosteoclastdifferentiationpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-6productionpositiveregulationofJUNkinaseactivitypositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofosteoclastdifferentiationpositiveregulationofproteinubiquitinationpositiveregulationofTcellcytokineproductionpositiveregulationofTcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingproteinautoubiquitinationproteinpolyubiquitinationregulationofimmunoglobulinproductionresponsetointerleukin-1stimulatoryC-typelectinreceptorsignalingpathwayTcellreceptorsignalingpathwayT-helper1typeimmuneresponse
Pyruvate carboxylase, mitochondrial
752
Pyruvate carboxylase, mitochondrial
816
9.1
88
0.13
PYCPYCP11498P11498gluconeogenesislipidmetabolicprocessNADHmetabolicprocessNADPmetabolicprocessnegativeregulationofgeneexpressionpositiveregulationbyhostofviralprocesspyruvatemetabolicprocessviralreleasefromhostcellviralRNAgenomepackaging
Kunitz-type protease inhibitor 1
77
Suppressor of tumorigenicity 14 protein
641
9.1
100
0.11
H3BR01ST14H3BR01Q9Y5Y6epithelialcellmorphogenesisinvolvedinplacentalbranchingkeratinocytedifferentiationneuraltubeclosureproteincatabolicprocessproteolysis
Elafin
83
Elafin
83
9.1
77
0.14
ELAFELAFP19957P19957antibacterialhumoralresponsecopulationinnateimmuneresponsepeptidecross-linking
Interleukin-17A
146
Interleukin-17A
99
9.0
84
0.13
IL17IL17Q16552Q16552adaptiveimmuneresponseapoptoticprocesscelldeathcell-cellsignalingcellularresponsetointerleukin-1defenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumfibroblastactivationgranulocytemigrationimmuneresponseinflammatoryresponseinnateimmuneresponseinterleukin-17-mediatedsignalingpathwayintestinalepithelialstructuremaintenanceNotchsignalingpathwaypositiveregulationofantimicrobialpeptideproductionpositiveregulationofbicellulartightjunctionassemblypositiveregulationofchemokine(C-X-Cmotif)ligand1productionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-16productionpositiveregulationofinterleukin-23productionpositiveregulationofinterleukin-6productionpositiveregulationofosteoclastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproduction
DNA repair protein XRCC1
12
DNA repair protein XRCC1
12
9.0
85
0.13
XRCC1XRCC1P18887P18887base-excisionrepaircerebellummorphogenesisdouble-strandbreakrepairvianonhomologousendjoininghippocampusdevelopmentnegativeregulationofprotectionfromnon-homologousendjoiningattelomerenegativeregulationofproteinADP-ribosylationpositiveregulationofDNAligaseactivitypositiveregulationofsinglestrandbreakrepairreplication-borndouble-strandbreakrepairviasisterchromatidexchangeresponsetohydroperoxideresponsetohypoxiaresponsetoorganicsubstanceresponsetoxenobioticstimulussinglestrandbreakrepairtelomericDNA-containingdoubleminutesformationvoluntarymusculoskeletalmovement
Norrin
96
Norrin
93
9.0
77
0.14
NDPNDPQ00604Q00604decidualizationextracellularmatrix-cellsignalingnervoussystemdevelopmentNorrinsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoftranscriptionDNA-templatedretinavasculaturemorphogenesisincamera-typeeyevacuoleorganizationvisualperceptionWntsignalingpathway
Putative nucleotidyltransferase MAB21L1
246
Putative nucleotidyltransferase MAB21L1
313
9.0
61
0.18
MB211MB211Q13394Q13394anatomicalstructuremorphogenesiscamera-typeeyedevelopmentcellpopulationproliferationeyedevelopmentpositiveregulationofcellpopulationproliferation
Electron transfer flavoprotein subunit alpha, mitochondrial
155
Electron transfer flavoprotein subunit beta
131
9.0
78
0.14
ETFAETFBP13804P38117cellularaminoacidcatabolicprocessfattyacidbeta-oxidationusingacyl-CoAdehydrogenaserespiratoryelectrontransportchain
Beta-secretase 2
344
Beta-secretase 2
344
9.0
75
0.15
BACE2BACE2Q9Y5Z0Q9Y5Z0amyloid-betametabolicprocessglucosehomeostasismembraneproteinectodomainproteolysisnegativeregulationofamyloidprecursorproteinbiosyntheticprocesspeptidehormoneprocessingproteolysis
Importin subunit alpha-3
248
Importin subunit alpha-3
248
9.0
84
0.13
IMA3IMA3O00629O00629NLS-bearingproteinimportintonucleusproteinimportintonucleus
Interleukin-17A
99
Interleukin-17F
154
9.0
84
0.13
IL17IL17FQ16552Q96PD4adaptiveimmuneresponseapoptoticprocesscelldeathcell-cellsignalingcellularresponsetointerleukin-1defenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumfibroblastactivationgranulocytemigrationimmuneresponseinflammatoryresponseinnateimmuneresponseinterleukin-17-mediatedsignalingpathwayintestinalepithelialstructuremaintenanceNotchsignalingpathwaypositiveregulationofantimicrobialpeptideproductionpositiveregulationofbicellulartightjunctionassemblypositiveregulationofchemokine(C-X-Cmotif)ligand1productionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-16productionpositiveregulationofinterleukin-23productionpositiveregulationofinterleukin-6productionpositiveregulationofosteoclastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductioncartilagedevelopmentnegativeregulationofangiogenesispositiveregulationofcytokineproductionpositiveregulationoflymphotoxinAproductionregulationofgranulocytemacrophagecolony-stimulatingfactorproductionregulationofinterleukin-2productionregulationofinterleukin-6productionregulationofinterleukin-8productionregulationoftransforminggrowthfactorbetareceptorsignalingpathway
A disintegrin and metalloproteinase with thrombospondin motifs 5
376
A disintegrin and metalloproteinase with thrombospondin motifs 5
342
9.0
63
0.18
ATS5ATS5Q9UNA0Q9UNA0defenseresponsetobacteriumextracellularmatrixdisassemblyextracellularmatrixorganizationmyoblastfusionnegativeregulationofcold-inducedthermogenesisproteolysistootheruption
Histone-lysine N-methyltransferase 2C
1078
Histone-lysine N-methyltransferase 2C
1069
9.0
67
0.17
KMT2CKMT2CQ8NEZ4Q8NEZ4chromatinorganizationhistoneH3-K4methylationhistoneH3-K4monomethylationpositiveregulationoftranscriptionbyRNApolymeraseII
Neurotrophin-4
97
Neurotrophin-4
201
9.0
93
0.12
NTF4NTF4P34130P34130adultlocomotorybehaviorepidermisdevelopmentganglionmothercellfatedeterminationinnervationlong-termmemorymechanoreceptordifferentiationmemorymodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwayneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofpeptidyl-serinephosphorylationregulationofneurondifferentiationsensoryorganboundaryspecificationtastebuddevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathway
Peptidyl-tRNA hydrolase 2, mitochondrial
86
Peptidyl-tRNA hydrolase 2, mitochondrial
86
9.0
111
0.1
PTH2PTH2Q9Y3E5Q9Y3E5apoptoticprocessnegativeregulationofanoikisnegativeregulationofgeneexpressionpositiveregulationofanoikis
Bone morphogenetic protein 10
389
Bone morphogenetic protein 10
388
9.0
80
0.14
BMP10BMP10O95393O95393activinreceptorsignalingpathwayadultheartdevelopmentatrialcardiacmuscletissuemorphogenesisBMPsignalingpathwaycardiacmusclecellproliferationcelladhesionhearttrabeculaformationkidneydevelopmentnegativeregulationofcardiacmusclehypertrophynegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofendothelialcellmigrationpathway-restrictedSMADproteinphosphorylationpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcardiacmusclehypertrophypositiveregulationofcartilagedevelopmentpositiveregulationofcellproliferationinvolvedinheartmorphogenesispositiveregulationofgeneexpressionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofsarcomereorganizationpositiveregulationoftranscriptionDNA-templatedregulationofcardiacmusclecontractionregulationofcardiacmusclehypertrophyinresponsetostresssarcomereorganizationSMADproteinsignaltransductionventricularcardiacmusclecelldevelopmentventricularcardiacmuscletissuemorphogenesis
Acyl-protein thioesterase 1
211
Acyl-protein thioesterase 1
173
9.0
68
0.16
LYPA1LYPA1O75608O75608fattyacidmetabolicprocessnegativeregulationofGolgitoplasmamembraneproteintransportproteindepalmitoylation
Amyloid-beta precursor protein
98
Amyloid-beta precursor protein
105
9.0
69
0.16
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Resistin
55
Resistin
55
9.4
67
0.16
RETNRETNQ99P87Q99P87fatcelldifferentiationnegativeregulationoffeedingbehaviorpositiveregulationofcollagenmetabolicprocesspositiveregulationofprogesteronesecretionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsynaptictransmissionresponsetoinsulin
A disintegrin and metalloproteinase with thrombospondin motifs 5
371
A disintegrin and metalloproteinase with thrombospondin motifs 5
342
9.4
74
0.14
ATS5ATS5Q9UNA0Q9UNA0defenseresponsetobacteriumextracellularmatrixdisassemblyextracellularmatrixorganizationmyoblastfusionnegativeregulationofcold-inducedthermogenesisproteolysistootheruption
Cystatin-8
105
Cystatin-8
139
9.4
69
0.15
CST8CST8P32766P32766
Phospholipid-transporting ATPase IG
200
Phospholipid-transporting ATPase IG
168
9.4
50
0.21
AT11CAT11CQ8NB49Q8NB49iontransmembranetransportphospholipidtranslocation
Chymotrypsinogen A
42
Pancreatic trypsin inhibitor
49
9.4
101
0.11
CTRABPT1P00766P00974digestionproteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Cubilin
81
Cubilin
81
9.4
65
0.16
CUBNCUBNO60494O60494cholesterolmetabolicprocesscobalaminmetabolicprocesscobalamintransportestablishmentoflocalizationincelllipoproteintransportreceptor-mediatedendocytosisresponsetobacteriumtissuehomeostasis
Vesicle-associated membrane protein 2
103
Syntaxin-1A
272
9.4
60
0.18
VAMP2STX1AP63045P32851calcium-ionregulatedexocytosiscellularresponsetoinsulinstimuluseosinophildegranulationexocyticinsertionofneurotransmitterreceptortopostsynapticmembraneGolgitoplasmamembraneproteintransporthormonesecretionlong-termsynapticpotentiationmembranefusionpositiveregulationofintracellularproteintransportproteintransportprotein-containingcomplexassemblyregulatedexocytosisregulationofdelayedrectifierpotassiumchannelactivityregulationofexocytosisregulationofsynapticvesiclerecyclingregulationofvesicle-mediatedtransportresponsetoglucoseSNAREcomplexassemblysynapticvesicledockingsynapticvesicleendocytosissynapticvesicleexocytosisvesiclefusionvesicle-mediatedtransportexocytosisinsulinsecretionintracellularproteintransportmodulationofexcitatorypostsynapticpotentialneurotransmittertransportpositiveregulationofcalciumion-dependentexocytosispositiveregulationofcatecholaminesecretionpositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofexocytosispositiveregulationofneurotransmittersecretionpositiveregulationofnorepinephrinesecretionproteinlocalizationtomembraneproteinsumoylationregulationofsynapticvesicleprimingresponsetogravitysecretionbycellsynapticvesiclefusiontopresynapticactivezonemembranevesicledocking
Poly [ADP-ribose] polymerase
970
Poly [ADP-ribose] polymerase
970
9.4
66
0.16
Q59FX0Q59FX0Q59FX0Q59FX0positiveregulationoftelomeremaintenanceviatelomerasespindleassemblyWntsignalingpathway
von Hippel-Lindau disease tumor suppressor
77
von Hippel-Lindau disease tumor suppressor
77
9.4
84
0.13
VHLVHLP40337P40337cellmorphogenesisnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationnegativeregulationofgeneexpressionnegativeregulationofreceptorsignalingpathwayviaJAK-STATnegativeregulationoftranscriptionelongationfromRNApolymeraseIIpromoternegativeregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationofcelldifferentiationpositiveregulationoftranscriptionDNA-templatedproteinstabilizationproteinubiquitinationproteolysisregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiaregulationoftranscriptionDNA-templated
Thrombomodulin
466
Thrombomodulin
464
9.4
76
0.14
TRBMTRBMP07204P07204bloodcoagulationbloodcoagulationcommonpathwayfemalepregnancynegativeregulationofbloodcoagulationnegativeregulationoffibrinolysisnegativeregulationofplateletactivationproteolysisresponsetocAMPresponsetolipopolysaccharideresponsetoX-rayzymogenactivation
Sequestosome-1
154
Sequestosome-1
131
9.4
56
0.19
SQSTMSQSTMQ13501Q13501aggrephagyapoptoticprocessautophagyautophagyofmitochondrionbrownfatcellproliferationcelldifferentiationendosomaltransportendosomeorganizationenergyhomeostasisimmunesystemprocessintracellularsignaltransductionmacroautophagymitophagynegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofapoptoticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinimportintonucleusproteinlocalizationproteinlocalizationtoperinuclearregionofcytoplasmproteinphosphorylationregulationofI-kappaBkinase/NF-kappaBsignalingregulationofmitochondrionorganizationregulationofproteincomplexstabilityregulationofRasproteinsignaltransductionresponsetoischemiaresponsetomitochondrialdepolarisationselectiveautophagytemperaturehomeostasistranscriptionbyRNApolymeraseIIubiquitin-dependentproteincatabolicprocess
Mitotic spindle assembly checkpoint protein MAD1
662
Mitotic spindle assembly checkpoint protein MAD1
662
9.4
68
0.16
MD1L1MD1L1Q9Y6D9Q9Y6D9attachmentofmitoticspindlemicrotubulestokinetochorecelldivisioncytoplasmicsequesteringofproteindeactivationofmitoticspindleassemblycheckpointmitoticspindleassemblycheckpointsignalingnegativeregulationofTcellproliferationpositiveregulationofmitoticcellcyclespindleassemblycheckpointregulationofmetaphaseplatecongressionthymusdevelopment
Growth/differentiation factor 8
282
Growth/differentiation factor 8
340
9.4
81
0.13
GDF8GDF8O08689O08689cellularresponsetodexamethasonestimulusmusclecellcellularhomeostasismyoblastmigrationinvolvedinskeletalmuscleregenerationnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofkinaseactivitynegativeregulationofmusclehypertrophynegativeregulationofmyoblastdifferentiationnegativeregulationofmyoblastproliferationnegativeregulationofproteinkinaseBsignalingnegativeregulationofsatellitecelldifferentiationnegativeregulationofskeletalmusclesatellitecellproliferationnegativeregulationofskeletalmuscletissuegrowthovulationcycleprocesspositiveregulationoflamellipodiumassemblypositiveregulationofmacrophagechemotaxispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionDNA-templatedresponsetoelectricalstimulusresponsetoestrogenresponsetoethanolresponsetogravityresponsetoheatresponsetomuscleactivityresponsetotestosteroneskeletalmuscleatrophySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
C-C motif chemokine 17
33
C-C motif chemokine 17
34
9.4
78
0.14
CCL17CCL17Q92583Q92583antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisnegativeregulationofmyoblastdifferentiationneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
DNA (cytosine-5)-methyltransferase 3A
559
DNA (cytosine-5)-methyltransferase 3A
517
9.4
81
0.13
DNM3ADNM3AQ9Y6K1Q9Y6K1agingC-5methylationofcytosinecellularresponsetoaminoacidstimuluscellularresponsetobisphenolAcellularresponsetoethanolcellularresponsetohypoxiaDNAmethylationDNAmethylationinvolvedinembryodevelopmentDNAmethylationinvolvedingametegenerationDNAmethylationoncytosineDNAmethylation-dependentheterochromatinassemblyhepatocyteapoptoticprocessmitoticcellcyclenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneurondifferentiationpositiveregulationofcelldeathregulationofgeneexpressionbygenomicimprintingresponsetococaineresponsetoestradiolresponsetoionizingradiationresponsetoleadionresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulusspermatogenesis
Serine protease 1
220
Serine protease inhibitor Kazal-type 1
39
9.4
82
0.13
TRY1ISK1P07477P00995digestionextracellularmatrixdisassemblyproteolysiscellularresponsetopeptidehormonestimulusnegativeregulationofcalciumionimportnegativeregulationofnitricoxidemediatedsignaltransductionnegativeregulationofpeptidyl-tyrosinephosphorylationnegativeregulationofserine-typeendopeptidaseactivitynitricoxidemediatedsignaltransductionpeptidyl-tyrosinephosphorylationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofepithelialcellproliferationpositiveregulationofpancreaticjuicesecretionpositiveregulationofpeptidehormonesecretionregulationofacrosomereactionregulationofstore-operatedcalciumentryresponsetoethanolresponsetonutrientlevelsspermcapacitation
Androgen receptor
584
Androgen receptor
597
9.4
69
0.15
ANDRANDRP15207P15207activationofprostateinductionbyandrogenreceptorsignalingpathwayandrogenreceptorsignalingpathwayanimalorganformationcellularresponsetoestrogenstimuluscellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetosteroidhormonestimuluscellularresponsetotestosteronestimuluscopulationepithelialcelldifferentiationinvolvedinprostateglanddevelopmentepithelialcellmorphogenesisfertilizationinuteroembryonicdevelopmentintracellularestrogenreceptorsignalingpathwayintracellularreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaylateralsproutinginvolvedinmammaryglandductmorphogenesisLeydigcelldifferentiationmalecourtshipbehaviormalegenitaliamorphogenesismalegonaddevelopmentmalesexdifferentiationmalesomaticsexdeterminationmammaryglandalveolusdevelopmentmorphogenesisofanepithelialfoldmulticellularorganismgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofepithelialcellproliferationnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofintegrinbiosyntheticprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellproliferationinvolvedinprostateglanddevelopmentpositiveregulationofgeneexpressionpositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofintegrinbiosyntheticprocesspositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpenileerectionpositiveregulationofphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIpositiveregulationoftranscriptionDNA-templatedprostateglandepitheliummorphogenesisprostateglandgrowthregulationofdevelopmentalgrowthregulationofgeneexpressionregulationofprostaticbudformationregulationofproteinlocalizationtoplasmamembraneregulationofsystemicarterialbloodpressureregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedreproductivebehaviorreproductivestructuredevelopmentreproductivesystemdevelopmentresponsetoestradiolresponsetoinsulinresponsetotestosteroneseminiferoustubuledevelopmentsinglefertilizationskeletalmusclehypertrophyspermatogenesistertiarybranchinginvolvedinmammaryglandductmorphogenesis
Bone morphogenetic protein 3
436
Bone morphogenetic protein 3
469
9.4
77
0.14
BMP3BMP3P12645P12645cartilagedevelopmentcell-cellsignalingosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationskeletalsystemdevelopmentSMADproteinsignaltransduction
Cytochrome P450 7A1
44
Cytochrome P450 7A1
44
9.4
88
0.12
CP7A1CP7A1P22680P22680bileacidandbilesalttransportbileacidbiosyntheticprocessbileacidsignalingpathwaycellularresponsetocholesterolcellularresponsetoglucosestimuluscholesterolcatabolicprocesscholesterolhomeostasisnegativeregulationofcollagenbiosyntheticprocessnegativeregulationoffattyacidbiosyntheticprocesspositiveregulationofcholesterolbiosyntheticprocessregulationofbileacidbiosyntheticprocessregulationofgeneexpressionresponsetoethanolsterolmetabolicprocess
Serine/threonine-protein kinase TNNI3K
705
Serine/threonine-protein kinase TNNI3K
705
9.3
79
0.14
TNI3KTNI3KQ59H18Q59H18bundleofHiscelltoPurkinjemyocytecommunicationproteinphosphorylationregulationofcardiacconductionregulationofcardiacmusclecontractionregulationofheartrateregulationofpostsynapseorganization
Suppressor of tumorigenicity 14 protein
641
Pancreatic trypsin inhibitor
73
9.3
88
0.12
ST14BPT1Q9Y5Y6P00974epithelialcellmorphogenesisinvolvedinplacentalbranchingkeratinocytedifferentiationneuraltubeclosureproteincatabolicprocessproteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Coagulation factor X
341
Coagulation factor X
164
9.3
69
0.16
FA10FA10P00743P00743bloodcoagulationproteolysis
Tyrosyl-DNA phosphodiesterase 2
137
Tyrosyl-DNA phosphodiesterase 2
147
9.3
65
0.17
TYDP2TYDP2Q9JJX7Q9JJX7double-strandbreakrepairneurondevelopment
Transcription factor p65
197
NF-kappa-B inhibitor beta
240
9.3
72
0.15
TF65IKBBQ04207Q60778animalorganmorphogenesiscellularresponsetoangiotensincellularresponsetohepatocytegrowthfactorstimuluscellularresponsetohydrogenperoxidecellularresponsetointerleukin-1cellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetolipoteichoicacidcellularresponsetonicotinecellularresponsetopeptidoglycancellularresponsetotumornecrosisfactorcellularresponsetovascularendothelialgrowthfactorstimuluschromatinorganizationcytokine-mediatedsignalingpathwaydefenseresponsedefenseresponsetotumorcellhairfollicledevelopmentI-kappaBkinase/NF-kappaBsignalinginflammatoryresponseinnateimmuneresponseinterleukin-1-mediatedsignalingpathwayliverdevelopmentnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofmiRNAtranscriptionnegativeregulationofNIK/NF-kappaBsignalingnegativeregulationofproteincatabolicprocessnegativeregulationofproteinsumoylationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneuropeptidesignalingpathwayNIK/NF-kappaBsignalingnucleotide-bindingoligomerizationdomaincontaining2signalingpathwaypositiveregulationofamyloid-betaformationpositiveregulationofcellpopulationproliferationpositiveregulationofchondrocytedifferentiationpositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-8productionpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofmiRNAmetabolicprocesspositiveregulationofmiRNAtranscriptionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofSchwanncelldifferentiationpositiveregulationofTcellreceptorsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimuluspositiveregulationoftranscriptionDNA-templatedpostsynapsetonucleussignalingpathwayproteincatabolicprocessregulationofDNA-templatedtranscriptioninresponsetostressregulationofinflammatoryresponseregulationofNIK/NF-kappaBsignalingregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetobacteriumresponsetocytokineresponsetointerleukin-1responsetomuramyldipeptideresponsetomusclestretchresponsetoorganicsubstanceresponsetoUV-BtranscriptionDNA-templatedtumornecrosisfactor-mediatedsignalingpathwaycytoplasmicsequesteringofNF-kappaBregulationofI-kappaBkinase/NF-kappaBsignalingsignaltransduction
Proprotein convertase subtilisin/kexin type 9
375
Low-density lipoprotein receptor
329
9.3
67
0.16
PCSK9LDLRQ8NBP7Q59FQ1apoptoticprocesscellularresponsetoinsulinstimuluscellularresponsetostarvationcholesterolhomeostasischolesterolmetabolicprocesskidneydevelopmentlipoproteinmetabolicprocessliverdevelopmentlow-densitylipoproteinparticlereceptorcatabolicprocesslysosomaltransportnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationoflow-densitylipoproteinparticlereceptorbindingnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofreceptorinternalizationnegativeregulationofreceptorrecyclingnegativeregulationofreceptor-mediatedendocytosisinvolvedincholesteroltransportnegativeregulationofsodiumiontransmembranetransporteractivityneurogenesisneurondifferentiationphospholipidmetabolicprocesspositiveregulationoflow-densitylipoproteinparticlereceptorcatabolicprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofreceptorinternalizationproteinautoprocessingregulationofneuronapoptoticprocessregulationofsignalingreceptoractivitytriglyceridemetabolicprocessamyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessarterymorphogenesiscellularresponsetofattyacidcellularresponsetolow-densitylipoproteinparticlestimuluscholesterolimportcholesteroltransportendocytosishigh-densitylipoproteinparticleclearanceintestinalcholesterolabsorptionlipidmetabolicprocesslipoproteincatabolicprocesslong-termmemorylow-densitylipoproteinparticleclearancenegativeregulationofamyloidfibrilformationnegativeregulationofastrocyteactivationnegativeregulationofgeneexpressionnegativeregulationofmicroglialcellactivationnegativeregulationofproteinmetabolicprocessphagocytosisphospholipidtransportplasmalipoproteinparticleclearancepositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationoflysosomalproteincatabolicprocesspositiveregulationoftriglyceridebiosyntheticprocessreceptor-mediatedendocytosisreceptor-mediatedendocytosisinvolvedincholesteroltransportregulationofcholesterolmetabolicprocessregulationofphosphatidylcholinecatabolicprocessregulationofproteinmetabolicprocessresponsetocaloricrestriction
Platelet-derived growth factor subunit B
141
Platelet-derived growth factor subunit B
124
9.4
59
0.18
PDGFBPDGFBP01127P01127activationofproteinkinaseactivityactivationofproteinkinaseBactivitycellchemotaxiscellularresponsetogrowthfactorstimuluscellularresponsetomycophenolicacidcellularresponsetoplatelet-derivedgrowthfactorstimulusembryonicplacentadevelopmentheartdevelopmentinterleukin-18-mediatedsignalingpathwaymetanephricglomerularmesangialcelldevelopmentmonocytechemotaxisnegativeregulationofgeneexpressionnegativeregulationofmiRNAtranscriptionnegativeregulationofphosphatidylinositolbiosyntheticprocessnegativeregulationofplateletactivationnegativeregulationofproteinbindingnegativeregulationoftranscriptionDNA-templatednegativeregulationofvascularassociatedsmoothmusclecelldifferentiationparacrinesignalingpeptidyl-serinephosphorylationpeptidyl-tyrosinephosphorylationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcalciumionimportpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-substrateadhesionpositiveregulationofchemotaxispositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglomerularfiltrationpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofhyaluronanbiosyntheticprocesspositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmetanephricmesenchymalcellmigrationpositiveregulationofmetanephricmesenchymalcellmigrationbyplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofmiRNAtranscriptionpositiveregulationofmitoticnucleardivisionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularassociatedsmoothmusclecelldedifferentiationpositiveregulationofvascularassociatedsmoothmusclecellmigrationpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseCsignalingproteinphosphorylationreactiveoxygenspeciesmetabolicprocessresponsetowounding
Resistin
108
Resistin
55
9.3
73
0.15
RETNRETNQ99P87Q99P87fatcelldifferentiationnegativeregulationoffeedingbehaviorpositiveregulationofcollagenmetabolicprocesspositiveregulationofprogesteronesecretionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsynaptictransmissionresponsetoinsulin
Mothers against decapentaplegic homolog 3
307
Zinc finger FYVE domain-containing protein 9
783
9.3
76
0.14
SMAD3ZFYV9P84022O95405activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwayactivinreceptorsignalingpathwayadrenalglanddevelopmentanatomicalstructuremorphogenesisBMPsignalingpathwaycelldifferentiationcell-celljunctionorganizationcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetovirusdevelopmentalgrowthembryoniccranialskeletonmorphogenesisembryonicforegutmorphogenesisembryonicpatternspecificationendodermdevelopmentextrinsicapoptoticsignalingpathwayheartloopingimmuneresponseimmunesystemdevelopmentinuteroembryonicdevelopmentJNKcascadelensfibercelldifferentiationliverdevelopmentmesodermformationnegativeregulationofapoptoticprocessnegativeregulationofcardiacmusclehypertrophyinresponsetostressnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcytosoliccalciumionconcentrationnegativeregulationoffatcelldifferentiationnegativeregulationofinflammatoryresponsenegativeregulationoflungbloodpressurenegativeregulationofosteoblastdifferentiationnegativeregulationofosteoblastproliferationnegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofwoundhealingnodalsignalingpathwayosteoblastdevelopmentparaxialmesodermmorphogenesispericardiumdevelopmentpositiveregulationofalkalinephosphataseactivitypositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofchondrocytedifferentiationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofextracellularmatrixassemblypositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofinterleukin-1betaproductionpositiveregulationofmiRNAtranscriptionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofpositivechemotaxispositiveregulationofproteinimportintonucleuspositiveregulationofstressfiberassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransforminggrowthfactorbeta3productionprimarymiRNAprocessingproteinstabilizationregulationofbindingregulationofepithelialcellproliferationregulationofimmuneresponseregulationofmiRNAtranscriptionregulationofstriatedmuscletissuedevelopmentregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiasignaltransductioninvolvedinregulationofgeneexpressionSMADproteincomplexassemblySMADproteinsignaltransductionsomitogenesisTcellactivationthyroidglanddevelopmenttransdifferentiationtransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentwoundhealingendocytosisendosomaltransport
Peptidoglycan recognition protein 1
28
Peptidoglycan recognition protein 1
28
9.3
69
0.16
PGRP1PGRP1Q9GK12Q9GK12defenseresponsetobacteriuminnateimmuneresponsenegativeregulationofcytokineproductionpeptidoglycancatabolicprocess
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
358
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
358
9.3
50
0.21
AB1IPAB1IPQ8R5A3Q8R5A3positiveregulationofcelladhesionsignaltransductionTcellactivationviaTcellreceptorcontactwithantigenboundtoMHCmoleculeonantigenpresentingcell
Glycoprotein hormones alpha chain
111
Follitropin subunit beta
112
9.3
80
0.13
GLHAFSHBP01215P01225follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationfemalegametegenerationfemalepregnancypositiveregulationofboneresorptionpositiveregulationofgeneexpressionprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationSertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
CD44 antigen
77
CD44 antigen
77
9.3
79
0.14
CD44CD44P16070P16070cartilagedevelopmentcelladhesioncellmigrationcell-celladhesioncell-matrixadhesioncellularresponsetofibroblastgrowthfactorstimuluscytokine-mediatedsignalingpathwayhyaluronancatabolicprocessinflammatoryresponsemonocyteaggregationnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofDNAdamageresponsesignaltransductionbyp53classmediatornegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorpositiveregulationofERK1andERK2cascadepositiveregulationofheterotypiccell-celladhesionpositiveregulationofmonocyteaggregationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationregulationoflamellipodiummorphogenesisTcellactivationwoundhealingspreadingofcells
Norrin
128
Norrin
95
9.3
78
0.14
NDPNDPQ00604Q00604decidualizationextracellularmatrix-cellsignalingnervoussystemdevelopmentNorrinsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoftranscriptionDNA-templatedretinavasculaturemorphogenesisincamera-typeeyevacuoleorganizationvisualperceptionWntsignalingpathway
Interleukin-17A
146
Interleukin-17F
107
9.3
86
0.12
IL17IL17FQ16552Q96PD4adaptiveimmuneresponseapoptoticprocesscelldeathcell-cellsignalingcellularresponsetointerleukin-1defenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumfibroblastactivationgranulocytemigrationimmuneresponseinflammatoryresponseinnateimmuneresponseinterleukin-17-mediatedsignalingpathwayintestinalepithelialstructuremaintenanceNotchsignalingpathwaypositiveregulationofantimicrobialpeptideproductionpositiveregulationofbicellulartightjunctionassemblypositiveregulationofchemokine(C-X-Cmotif)ligand1productionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-16productionpositiveregulationofinterleukin-23productionpositiveregulationofinterleukin-6productionpositiveregulationofosteoclastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductioncartilagedevelopmentnegativeregulationofangiogenesispositiveregulationofcytokineproductionpositiveregulationoflymphotoxinAproductionregulationofgranulocytemacrophagecolony-stimulatingfactorproductionregulationofinterleukin-2productionregulationofinterleukin-6productionregulationofinterleukin-8productionregulationoftransforminggrowthfactorbetareceptorsignalingpathway
Glucocorticoid receptor
473
Glucocorticoid receptor
463
9.3
68
0.16
GCRGCRP04150P04150adrenalglanddevelopmentapoptoticprocesscellcyclecelldivisioncellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinorganizationchromosomesegregationglucocorticoidmetabolicprocessintracellularsteroidhormonereceptorsignalingpathwaymammaryglandductmorphogenesismaternalbehaviornegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedsignaltransduction
DCC-interacting protein 13-alpha
570
DCC-interacting protein 13-alpha
570
9.3
57
0.19
DP13ADP13AQ9UKG1Q9UKG1adiponectin-activatedsignalingpathwaycellcyclecellularresponsetohepatocytegrowthfactorstimulusinsulinreceptorsignalingpathwaynegativeregulationofFc-gammareceptorsignalingpathwayinvolvedinphagocytosispositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofglucoseimportpositiveregulationofmacropinocytosispositiveregulationofmelaninbiosyntheticprocessproteinimportintonucleusregulationoffibroblastmigrationregulationofG1/Stransitionofmitoticcellcycleregulationofglucoseimportregulationofinnateimmuneresponseregulationofproteinlocalizationtoplasmamembraneregulationoftoll-likereceptor4signalingpathwaysignaltransductionsignalingtransforminggrowthfactorbetareceptorsignalingpathway
Glutathione S-transferase Mu 1
87
Glutathione S-transferase Mu 1
87
9.3
72
0.15
GSTM1GSTM1P09488P09488cellulardetoxificationofnitrogencompoundglutathionederivativebiosyntheticprocessglutathionemetabolicprocesshepoxilinbiosyntheticprocessnitrobenzenemetabolicprocessprostaglandinmetabolicprocessxenobioticcatabolicprocess
Properdin
127
Properdin
391
9.3
62
0.17
PROPPROPP27918P27918complementactivationcomplementactivationalternativepathwaydefenseresponsetobacteriumimmuneresponsepositiveregulationofimmuneresponsepositiveregulationofopsonization
Androgen receptor
594
Androgen receptor
584
9.1
70
0.16
ANDRANDRP15207P15207activationofprostateinductionbyandrogenreceptorsignalingpathwayandrogenreceptorsignalingpathwayanimalorganformationcellularresponsetoestrogenstimuluscellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetosteroidhormonestimuluscellularresponsetotestosteronestimuluscopulationepithelialcelldifferentiationinvolvedinprostateglanddevelopmentepithelialcellmorphogenesisfertilizationinuteroembryonicdevelopmentintracellularestrogenreceptorsignalingpathwayintracellularreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaylateralsproutinginvolvedinmammaryglandductmorphogenesisLeydigcelldifferentiationmalecourtshipbehaviormalegenitaliamorphogenesismalegonaddevelopmentmalesexdifferentiationmalesomaticsexdeterminationmammaryglandalveolusdevelopmentmorphogenesisofanepithelialfoldmulticellularorganismgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofepithelialcellproliferationnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofintegrinbiosyntheticprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellproliferationinvolvedinprostateglanddevelopmentpositiveregulationofgeneexpressionpositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofintegrinbiosyntheticprocesspositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpenileerectionpositiveregulationofphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIpositiveregulationoftranscriptionDNA-templatedprostateglandepitheliummorphogenesisprostateglandgrowthregulationofdevelopmentalgrowthregulationofgeneexpressionregulationofprostaticbudformationregulationofproteinlocalizationtoplasmamembraneregulationofsystemicarterialbloodpressureregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedreproductivebehaviorreproductivestructuredevelopmentreproductivesystemdevelopmentresponsetoestradiolresponsetoinsulinresponsetotestosteroneseminiferoustubuledevelopmentsinglefertilizationskeletalmusclehypertrophyspermatogenesistertiarybranchinginvolvedinmammaryglandductmorphogenesis
Coagulation factor XI
416
Amyloid-beta precursor protein
300
9.1
99
0.11
FA11A4P03951P05067bloodcoagulationbloodcoagulationintrinsicpathwayplasminogenactivationpositiveregulationoffibrinolysisproteolysiszymogenactivationadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
PWWP domain-containing DNA repair factor 3A
501
PWWP domain-containing DNA repair factor 3A
501
9.0
56
0.2
PWP3APWP3AQ2TAK8Q2TAK8chromatinorganizationDNArepair
GTP-binding protein RAD
221
GTP-binding protein RAD
221
9.0
86
0.13
RADRADP55042P55042negativeregulationofhighvoltage-gatedcalciumchannelactivitysmallGTPasemediatedsignaltransduction
EKC/KEOPS complex subunit TPRKB
167
EKC/KEOPS complex subunit TP53RK
91
9.0
89
0.12
TPRKBPRPKQ9Y3C4Q96S44telomeremaintenanceviarecombinationtRNAthreonylcarbamoyladenosinemodificationproteinphosphorylationregulationofsignaltransductionbyp53classmediatortRNAprocessingtRNAthreonylcarbamoyladenosinemetabolicprocess
Vascular endothelial growth factor A
77
Vascular endothelial growth factor A
87
9.0
75
0.15
VEGFAVEGFAQ96NW5Q96NW5activationofproteinkinaseactivityangiogenesisarterymorphogenesisbasophilchemotaxisbranchinginvolvedinbloodvesselmorphogenesiscamera-typeeyemorphogenesiscardiacmusclecelldevelopmentcardiacvascularsmoothmusclecelldevelopmentcellmaturationcellmigrationinvolvedinsproutingangiogenesiscellularresponsetohypoxiacellularresponsetovascularendothelialgrowthfactorstimuluscellularstressresponsetoacidchemicalcommissuralneuronaxonguidancecoronaryarterymorphogenesiscoronaryveinmorphogenesisdopaminergicneurondifferentiationendothelialcellchemotaxisepithelialcelldifferentiationeyephotoreceptorcelldevelopmentheartmorphogenesisinuteroembryonicdevelopmentinductionofpositivechemotaxiskidneydevelopmentlactationlungdevelopmentlymphvesselmorphogenesismacrophagedifferentiationmammaryglandalveolusdevelopmentmesodermdevelopmentmonocytedifferentiationmotorneuronmigrationnegativeregulationofadherensjunctionorganizationnegativeregulationofapoptoticprocessnegativeregulationofblood-brainbarrierpermeabilitynegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofestablishmentofendothelialbarriernegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentoutflowtractmorphogenesisovarianfollicledevelopmentpositivechemotaxispositiveregulationofangiogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelladhesionpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellmigrationbyvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofcellproliferationbyVEGF-activatedplateletderivedgrowthfactorreceptorsignalingpathwaypositiveregulationofcold-inducedthermogenesispositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialtubeformationpositiveregulationofERK1andERK2cascadepositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofhistonedeacetylaseactivitypositiveregulationofleukocytemigrationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmastcellchemotaxispositiveregulationofneuroblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofpositivechemotaxispositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinkinaseCsignalingpositiveregulationofproteinkinaseDsignalingpositiveregulationofproteinlocalizationtoearlyendosomepositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorinternalizationpositiveregulationofretinalganglioncellaxonguidancepositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftrophoblastcellmigrationpositiveregulationofvascularpermeabilitypost-embryoniccamera-typeeyedevelopmentprimitiveerythrocytedifferentiationregulationofcellshaperegulationofnitricoxidemediatedsignaltransductionregulationofretinalganglioncellaxonguidanceregulationoftranscriptionbyRNApolymeraseIIresponsetohypoxiasproutingangiogenesissurfactanthomeostasistubeformationvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorreceptor-2signalingpathwayvascularendothelialgrowthfactorsignalingpathwayvascularwoundhealingvasculogenesisVEGF-activatedneuropilinsignalingpathway
Kinesin-like protein KIF2C
245
Kinesin-like protein KIF2C
287
9.0
63
0.18
KIF2CKIF2CQ99661Q99661attachmentofmitoticspindlemicrotubulestokinetochorecelldivisionestablishmentormaintenanceofmicrotubulecytoskeletonpolaritymetaphaseplatecongressionmicrotubuledepolymerizationmicrotubule-basedmovementmitoticmetaphaseplatecongressionregulationofchromosomesegregation
C-X-C motif chemokine 10
30
C-X-C motif chemokine 10
30
9.0
64
0.17
CXL10CXL10P17515P17515adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideantiviralinnateimmuneresponsecellularresponsetointerleukin-17cellularresponsetolipopolysaccharidecellularresponsetoviruschemokine-mediatedsignalingpathwaychemotaxisdefenseresponsetovirusendothelialcellactivationGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponsekillingofcellsofanotherorganismnegativeregulationofangiogenesisnegativeregulationofmyoblastdifferentiationnegativeregulationofmyoblastfusionneutrophilchemotaxispositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofleukocytechemotaxispositiveregulationofmonocytechemotaxispositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofTcellmigrationregulationofapoptoticprocessregulationofcellpopulationproliferationregulationofendothelialtubemorphogenesisregulationofTcellchemotaxisresponsetobacteriumTcellchemotaxis
Prorelaxin H2
171
Prorelaxin H2
35
9.0
57
0.2
REL2REL2P04090P04090femalepregnancypositiveregulationofangiogenesispositiveregulationofgeneexpressionregulationofcatalyticactivity
Inhibitor of nuclear factor kappa-B kinase subunit beta
716
Inhibitor of nuclear factor kappa-B kinase subunit beta
716
9.0
69
0.16
IKKBIKKBO14920O14920antigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassITAP-dependentcellularresponsetotumornecrosisfactorcorticalactincytoskeletonorganizationFc-epsilonreceptorsignalingpathwayI-kappaBkinase/NF-kappaBsignalinginflammatoryresponseinnateimmuneresponseinterleukin-1-mediatedsignalingpathwaynegativeregulationofbicellulartightjunctionassemblynegativeregulationofmyosin-light-chain-phosphataseactivitypeptidyl-serinephosphorylationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedproteinlocalizationtoplasmamembraneproteinphosphorylationregulationofestablishmentofendothelialbarrierregulationofphosphorylationregulationoftumornecrosisfactor-mediatedsignalingpathwayresponsetovirusstimulatoryC-typelectinreceptorsignalingpathwaystress-activatedMAPKcascadeTcellreceptorsignalingpathwaytumornecrosisfactor-mediatedsignalingpathway
Amyloid-beta precursor protein
98
Amyloid-beta precursor protein
98
9.0
81
0.14
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Serine protease 1
48
Amyloid-beta precursor protein
300
9.2
99
0.11
TRY1A4P00760P05067digestionproteolysisadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Guanine nucleotide-binding protein G(i) subunit alpha-1
305
Guanine nucleotide-binding protein G(i) subunit alpha-1
305
9.1
50
0.22
GNAI1GNAI1P63096P63096adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormone
Glycoprotein hormones alpha chain
83
Follitropin subunit beta
50
9.1
78
0.14
GLHAFSHBP01215P01225follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationfemalegametegenerationfemalepregnancypositiveregulationofboneresorptionpositiveregulationofgeneexpressionprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationSertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Protein phosphatase 1A
72
Protein phosphatase 1A
72
9.0
70
0.16
PPM1APPM1AP35813P35813cellularresponsetotransforminggrowthfactorbetastimulusdephosphorylationN-terminalproteinmyristoylationnegativeregulationofBMPsignalingpathwaynegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofNIK/NF-kappaBsignalingnegativeregulationofSMADproteincomplexassemblynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypeptidyl-threoninedephosphorylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofproteinexportfromnucleuspositiveregulationoftranscriptionDNA-templatedproteindephosphorylationproteinexportfromnucleusregulationofcellcycle
Kunitz-type protease inhibitor 2
47
Trypsin-3
105
9.1
96
0.12
SPIT2TRY3O43291P35030basementmembraneorganizationcellularresponsetoBMPstimulusepithelialcellmorphogenesisinvolvedinplacentalbranchingestablishmentormaintenanceofcellpolaritynegativeregulationofcellmotilitynegativeregulationofcell-celladhesionnegativeregulationofneuralprecursorcellproliferationneuraltubeclosureantimicrobialhumoralresponsedigestionendothelialcellmigrationproteolysiszymogenactivation
Trypsin-3
105
Amyloid-beta precursor protein
300
9.1
95
0.12
TRY3A4P35030P05067antimicrobialhumoralresponsedigestionendothelialcellmigrationproteolysiszymogenactivationadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
C-C motif chemokine 16
60
C-C motif chemokine 16
60
9.0
54
0.21
CCL16CCL16O15467O15467cellcommunicationcell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
Histone-lysine N-methyltransferase 2C
1060
Histone-lysine N-methyltransferase 2C
1069
9.0
63
0.18
KMT2CKMT2CQ8NEZ4Q8NEZ4chromatinorganizationhistoneH3-K4methylationhistoneH3-K4monomethylationpositiveregulationoftranscriptionbyRNApolymeraseII
Neurotrophin-4
201
Neurotrophin-4
158
9.0
91
0.12
NTF4NTF4P34130P34130adultlocomotorybehaviorepidermisdevelopmentganglionmothercellfatedeterminationinnervationlong-termmemorymechanoreceptordifferentiationmemorymodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwayneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofpeptidyl-serinephosphorylationregulationofneurondifferentiationsensoryorganboundaryspecificationtastebuddevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathway
Transportin-3
912
Transportin-3
793
9.0
68
0.16
TNPO3TNPO3Q9Y5L0Q9Y5L0proteinimportintonucleus
Growth/differentiation factor 2
392
Growth/differentiation factor 2
393
9.0
82
0.14
GDF2GDF2Q9UK05Q9UK05activinreceptorsignalingpathwayangiogenesisbloodvesselmorphogenesisBMPsignalingpathwaybranchinginvolvedinbloodvesselmorphogenesiscartilagedevelopmentcellularironionhomeostasiscellularresponsetoBMPstimulusnegativeregulationofangiogenesisnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellgrowthnegativeregulationofDNAbiosyntheticprocessnegativeregulationofDNAreplicationnegativeregulationofendothelialcellmigrationnegativeregulationofendothelialcellproliferationossificationosteoblastdifferentiationpathway-restrictedSMADproteinphosphorylationpositiveregulationofangiogenesispositiveregulationofBMPsignalingpathwaypositiveregulationofcartilagedevelopmentpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofinterleukin-8productionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedSMADproteinsignaltransductiontranscriptionbyRNApolymeraseIIvasculogenesis
Fibrinogen alpha chain
55
Fibrinogen alpha chain
68
9.0
77
0.14
FIBAFIBAP02671P02671adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumion
Neurotrophin-3
248
Neurotrophin-3
205
9.0
88
0.13
NTF3NTF3P20783P20783activationofGTPaseactivityactivationofproteinkinaseBactivitycell-cellsignalinginductionofpositivechemotaxismemorymodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnegativeregulationofpeptidyl-tyrosinephosphorylationnervedevelopmentnervegrowthfactorsignalingpathwaynervoussystemdevelopmentneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofactincytoskeletonreorganizationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofreceptorinternalizationregulationofapoptoticprocessregulationofneurondifferentiationsignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
40S ribosomal protein S20
70
40S ribosomal protein S29
39
9.0
50
0.22
G1SIZ2G1U7M4G1SIZ2G1U7M4translation
Glutathione S-transferase Mu 4
87
Glutathione S-transferase Mu 4
78
9.0
71
0.16
GSTM4GSTM4Q03013Q03013glutathionemetabolicprocesslong-chainfattyacidbiosyntheticprocessnitrobenzenemetabolicprocessxenobioticcatabolicprocess
Protein S100-A3
23
Protein S100-A3
86
9.0
79
0.14
S10A3S10A3P33764P33764
Transforming growth factor beta-1 proprotein
355
Transforming growth factor beta-1 proprotein
326
9.0
75
0.15
TGFB1TGFB1P07200P07200adaptiveimmuneresponsebasedonsomaticrecombinationofimmunereceptorsbuiltfromimmunoglobulinsuperfamilydomainsaorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaybranchelongationinvolvedinmammaryglandductbranchingbronchioledevelopmentcellmigrationcellmorphogenesiscell-celljunctionorganizationcellularcalciumionhomeostasiscellularresponsetoionizingradiationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetoviruschondrocytedifferentiationcolumnar/cuboidalepithelialcellmaturationcommon-partnerSMADproteinphosphorylationembryonicliverdevelopmentenamelmineralizationendodermdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialcellproliferationepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayfacemorphogenesisgeneexpressiongermcellmigrationhematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponseLangerhanscelldifferentiationlensfibercelldifferentiationlipopolysaccharide-mediatedsignalingpathwaylungalveolusdevelopmentlymphnodedevelopmentmammaryglandbranchinginvolvedinthelarcheMAPKcascademembraneproteinintracellulardomainproteolysismusclecellcellularhomeostasisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofepithelialcellproliferationnegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofinterleukin-17productionnegativeregulationofmacrophagecytokineproductionnegativeregulationofmyoblastdifferentiationnegativeregulationofossificationnegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationofTcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneuraltubeclosureNotchsignalingpathwayoligodendrocytedevelopmentossificationinvolvedinboneremodelingosteoclastdifferentiationpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocessphospholipidhomeostasispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofhistoneacetylationpositiveregulationofhistonedeacetylationpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofodontogenesispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorclusteringpositiveregulationofregulatoryTcelldifferentiationpositiveregulationofSMADproteinsignaltransductionpositiveregulationofstemcellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofactincytoskeletonreorganizationregulationofbindingregulationofbranchinginvolvedinmammaryglandductmorphogenesisregulationofcartilagedevelopmentregulationofcellpopulationproliferationregulationofDNAbindingregulationofinterleukin-23productionregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofsodiumiontransportregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulatoryTcelldifferentiationresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductionstemcellproliferationsurfactanthomeostasisTcellhomeostasisTcellproliferationtoleranceinductiontoselfantigentransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmenturetericbuddevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
NKG2-D type II integral membrane protein
99
NKG2-D type II integral membrane protein
105
9.0
79
0.14
NKG2DNKG2DP26718P26718adaptiveimmuneresponsecelldifferentiationcellularresponsetolipopolysaccharidedefenseresponsetoGram-positivebacteriumnaturalkillercellactivationnaturalkillercellmediatedcytotoxicitynegativeregulationofGTPaseactivitynegativeregulationofnaturalkillercellchemotaxisnitricoxidebiosyntheticprocesspositiveregulationofinterferon-gammaproductionpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnitricoxidebiosyntheticprocesssignaltransductionstimulatoryC-typelectinreceptorsignalingpathwayTcellcostimulation
Growth/differentiation factor 11
371
Growth/differentiation factor 11
341
9.0
89
0.13
GDF11GDF11O95390O95390amacrinecelldifferentiationcamera-typeeyemorphogenesiscellpopulationproliferationmesodermdevelopmentmetanephrosdevelopmentnegativeregulationofamacrinecelldifferentiationnegativeregulationofcellpopulationproliferationnervoussystemdevelopmentpositiveregulationofpathway-restrictedSMADproteinphosphorylationroofofmouthdevelopmentskeletalsystemdevelopmentSMADproteinsignaltransductionspinalcordanterior/posteriorpatterningtypeBpancreaticcellmaturationuretericbuddevelopment
Histone-lysine N-methyltransferase 2C
1081
Histone-lysine N-methyltransferase 2C
1069
9.0
68
0.16
KMT2CKMT2CQ8NEZ4Q8NEZ4chromatinorganizationhistoneH3-K4methylationhistoneH3-K4monomethylationpositiveregulationoftranscriptionbyRNApolymeraseII
Transforming growth factor beta-3 proprotein
409
Transforming growth factor beta-3 proprotein
377
9.0
83
0.13
TGFB3TGFB3P10600P10600agingBMPsignalingpathwaycell-celljunctionorganizationdetectionofhypoxiadigestivetractdevelopmentembryonicneurocraniummorphogenesisfacemorphogenesisfemalepregnancyfrontalsuturemorphogenesisinuteroembryonicdevelopmentinnereardevelopmentlungalveolusdevelopmentmammaryglanddevelopmentnegativeregulationofcellpopulationproliferationnegativeregulationofmacrophagecytokineproductionnegativeregulationofneuronapoptoticprocessnegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofvascularassociatedsmoothmusclecellproliferationodontogenesisossificationinvolvedinboneremodelingpositiveregulationofapoptoticprocesspositiveregulationofbonemineralizationpositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationoffilopodiumassemblypositiveregulationofMAPKcascadepositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofSMADproteinsignaltransductionpositiveregulationofstressfiberassemblypositiveregulationoftightjunctiondisassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofcellpopulationproliferationresponsetoestrogenresponsetohypoxiaresponsetolaminarfluidshearstressresponsetoprogesteronesalivaryglandmorphogenesissecondarypalatedevelopmentSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwayuterinewallbreakdownwoundhealing
Interleukin-17F
154
Interleukin-17F
107
8.9
85
0.13
IL17FIL17FQ96PD4Q96PD4adaptiveimmuneresponsecartilagedevelopmentdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminflammatoryresponseinnateimmuneresponseinterleukin-17-mediatedsignalingpathwaynegativeregulationofangiogenesispositiveregulationofantimicrobialpeptideproductionpositiveregulationofchemokine(C-X-Cmotif)ligand1productionpositiveregulationofcytokineproductionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofinterleukin-6productionpositiveregulationoflymphotoxinAproductionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofgranulocytemacrophagecolony-stimulatingfactorproductionregulationofinterleukin-2productionregulationofinterleukin-6productionregulationofinterleukin-8productionregulationoftransforminggrowthfactorbetareceptorsignalingpathway
Adenylate cyclase type 2
911
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
237
8.9
83
0.13
ADCY2GNAS2P26769P04896adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycAMPbiosyntheticprocesscAMP-mediatedsignalingcellularresponsetoforskolinadenylatecyclase-activatingadrenergicreceptorsignalingpathwayadenylatecyclase-activatingdopaminereceptorsignalingpathwaybonedevelopmentcognitiondevelopmentalgrowthhairfollicleplacodeformationplateletaggregationpositiveregulationofcAMP-mediatedsignalingpositiveregulationofGTPaseactivitysensoryperceptionofchemicalstimulus
Fibrinogen gamma chain
35
Fibrinogen gamma chain
45
9.0
70
0.16
FIBGFIBGP02679P02679bloodcoagulationfibrinclotformationcell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetointerleukin-6fibrinolysisnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofplateletaggregationplasminogenactivationplateletaggregationplateletmaturationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationproteinsecretionprotein-containingcomplexassemblyresponsetocalciumion
Fibrinogen beta chain
106
Fibrinogen beta chain
106
8.9
81
0.14
FIBBFIBBP02675P02675adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumion
cGMP-dependent 3',5'-cyclic phosphodiesterase
391
cGMP-dependent 3',5'-cyclic phosphodiesterase
393
8.9
53
0.21
PDE2APDE2AO00408O00408adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayaortadevelopmentcAMP-mediatedsignalingcellularresponseto2378-tetrachlorodibenzodioxinecellularresponsetocAMPcellularresponsetocGMPcellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimuluscellularresponsetomacrophagecolony-stimulatingfactorstimuluscellularresponsetomechanicalstimuluscellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetoxenobioticstimuluscGMPcatabolicprocesscGMP-mediatedsignalingestablishmentofendothelialbarrierheartvalvedevelopmentmonocytedifferentiationnegativeregulationofcAMP-mediatedsignalingnegativeregulationofcGMP-mediatedsignalingnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofvascularpermeabilitypositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationofvascularpermeabilityregulationofcAMP-mediatedsignalingregulationofcGMP-mediatedsignalingregulationofmitochondrionorganizationsignaltransductionventricularseptumdevelopment
Urokinase plasminogen activator surface receptor
25
Urokinase plasminogen activator surface receptor
93
6.9
64
0.23
UPARUPARQ03405Q03405bloodcoagulationchemotaxisnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaynegativeregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofDNAbindingpositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofhomotypiccell-celladhesionpositiveregulationofproteinphosphorylationpositiveregulationofreleaseofcytochromecfrommitochondriaregulationofcelladhesionregulationoffibrinolysisregulationofplasminogenactivationregulationofproteolysissignaltransductionurokinaseplasminogenactivatorsignalingpathway
Glutamate receptor 2
330
Glutamate receptor 4
331
9.1
76
0.14
GRIA2GRIA4P19491P19493chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumionmodulationofchemicalsynaptictransmissionnegativeregulationofsmoothmusclecellapoptoticprocesspositiveregulationofsynaptictransmissionglutamatergicregulationofsynapsestructureoractivity
N6-adenosine-methyltransferase catalytic subunit
500
N6-adenosine-methyltransferase non-catalytic subunit
120
6.4
78
0.2
MTA70MET14Q86U44Q9HCE5adenosinetoinosineeditingcellularresponsetoDNAdamagestimuluscellularresponsetoUVcircadianrhythmdosagecompensationbyinactivationofXchromosomeendothelialtohematopoietictransitionforebrainradialglialcelldifferentiationgliogenesisinnateimmuneresponsemRNAcatabolicprocessmRNAdestabilizationmRNAmethylationmRNAprocessingmRNAsplicingviaspliceosomenegativeregulationofNotchsignalingpathwaynegativeregulationoftypeIinterferon-mediatedsignalingpathwayoogenesispositiveregulationofcap-independenttranslationalinitiationpositiveregulationoftranslationprimarymiRNAprocessingregulationofhematopoieticstemcelldifferentiationregulationofmeioticcellcycleregulationofTcelldifferentiationRNAmethylationspermatogenesisstemcellpopulationmaintenancenegativeregulationofhematopoieticprogenitorcelldifferentiation
Neutrophil defensin 3
68
Neutrophil defensin 3
94
7.9
nan
nan
DEF3DEF3P59666P59666antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetovirusinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Nitric oxide synthase, endothelial
96
Nitric oxide synthase, endothelial
101
3.7
77
0.35
NOS3NOS3P29473P29473argininecatabolicprocessbloodcoagulationcellularresponsetolaminarfluidshearstressmitochondrionorganizationnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofleukocytecell-celladhesionnitricoxidebiosyntheticprocesspositiveregulationofguanylatecyclaseactivity
Growth/differentiation factor 8
281
Growth/differentiation factor 8
339
8.6
69
0.17
GDF8GDF8O14793O14793cellularresponsetodexamethasonestimulusmusclecellcellularhomeostasismuscleorgandevelopmentmyoblastmigrationinvolvedinskeletalmuscleregenerationnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofkinaseactivitynegativeregulationofmusclehypertrophynegativeregulationofmyoblastdifferentiationnegativeregulationofmyoblastproliferationnegativeregulationofproteinkinaseBsignalingnegativeregulationofsatellitecelldifferentiationnegativeregulationofskeletalmusclesatellitecellproliferationnegativeregulationofskeletalmuscletissuegrowthovulationcycleprocesspositiveregulationoflamellipodiumassemblypositiveregulationofmacrophagechemotaxispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionDNA-templatedresponsetoelectricalstimulusresponsetoestrogenresponsetoethanolresponsetogravityresponsetoheatresponsetomuscleactivityresponsetotestosteroneskeletalmuscleatrophySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Neutrophil defensin 1
68
Neutrophil defensin 1
83
6.1
76
0.22
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismmodificationbyhostofsymbiontmembraneTcellchemotaxis
Hepatocyte growth factor
206
Hepatocyte growth factor
128
4.6
65
0.34
HGFHGFP14210P14210animalorganregenerationcellchemotaxiscellmorphogenesiscellularresponsetohepatocytegrowthfactorstimulusepithelialcellproliferationepithelialtomesenchymaltransitionhepatocytegrowthfactorreceptorsignalingpathwayliverdevelopmentmitoticcellcyclemyoblastproliferationnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-6productionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofreleaseofcytochromecfrommitochondriapositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofinterleukin-10productionpositiveregulationofMAPKcascadepositiveregulationofmyelinationpositiveregulationofneuronprojectionregenerationpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofbranchinginvolvedinsalivaryglandmorphogenesisbymesenchymal-epithelialsignalingregulationofp38MAPKcascaderegulationoftau-proteinkinaseactivityskeletalmusclecellproliferation
Natural killer cells antigen CD94
59
NKG2-A/NKG2-B type II integral membrane protein
119
6.8
63
0.23
KLRD1NKG2AQ13241P26715adaptiveimmuneresponsecellsurfacereceptorsignalingpathwaynaturalkillercellmediatedimmunitynegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofTcellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicityregulationofnaturalkillercellactivationstimulatoryC-typelectinreceptorsignalingpathwayCD8-positivegamma-deltaintraepithelialTcelldifferentiationinnateimmuneresponsenaturalkillercellinhibitorysignalingpathway
Defensin alpha 5
93
Defensin alpha 5
65
9.6
59
0.18
DEF5DEF5Q01523Q01523antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismpositiveregulationofinterleukin-8productionpositiveregulationofmembranepermeabilityproteinhomotetramerization
Serine/threonine-protein kinase Chk1
57
Claspin
944
5.7
nan
nan
CHK1CLSPNO14757Q9HAW4apoptoticprocessapoptoticprocessinvolvedindevelopmentcellularresponsetocaffeinecellularresponsetoDNAdamagestimuluscellularresponsetomechanicalstimulusDNAdamagecheckpointsignalingDNAdamageinducedproteinphosphorylationDNArepairDNAreplicationepigeneticmaintenanceofchromatinintranscription-competentconformationG2/MtransitionofmitoticcellcycleinnercellmasscellproliferationintracellularsignaltransductionmitoticG2DNAdamagecheckpointsignalingmitoticG2/MtransitioncheckpointnegativeregulationofDNAbiosyntheticprocessnegativeregulationofG0toG1transitionnegativeregulationofmitoticnucleardivisionnucleusorganizationpeptidyl-threoninephosphorylationpositiveregulationofcellcycleproteinphosphorylationregulationofcellpopulationproliferationregulationofdouble-strandbreakrepairviahomologousrecombinationregulationofhistoneH3-K9acetylationregulationofmitoticcentrosomeseparationregulationofsignaltransductionbyp53classmediatorregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoUV-inducedDNAdamagereplicativesenescenceactivationofproteinkinaseactivityDNAreplicationcheckpointsignalingmitoticDNAreplicationcheckpointsignalingpeptidyl-serinephosphorylation
Lysine-specific histone demethylase 2
278
Lysine-specific histone demethylase 2
53
9.6
60
0.17
KDM1BKDM1BQ8NB78Q8NB78DNAmethylationinvolvedingametegenerationhistoneH3-K4demethylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNAmethylationregulationofgeneexpressionbygenomicimprinting
Chymotrypsinogen A
220
Serine protease inhibitor Kazal-type 1
39
9.1
80
0.14
CTRAISK1P00766P00995digestionproteolysiscellularresponsetopeptidehormonestimulusnegativeregulationofcalciumionimportnegativeregulationofnitricoxidemediatedsignaltransductionnegativeregulationofpeptidyl-tyrosinephosphorylationnegativeregulationofserine-typeendopeptidaseactivitynitricoxidemediatedsignaltransductionpeptidyl-tyrosinephosphorylationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofepithelialcellproliferationpositiveregulationofpancreaticjuicesecretionpositiveregulationofpeptidehormonesecretionregulationofacrosomereactionregulationofstore-operatedcalciumentryresponsetoethanolresponsetonutrientlevelsspermcapacitation
NKG2-D type II integral membrane protein
96
NKG2-D type II integral membrane protein
99
7.7
67
0.19
NKG2DNKG2DP26718P26718adaptiveimmuneresponsecelldifferentiationcellularresponsetolipopolysaccharidedefenseresponsetoGram-positivebacteriumnaturalkillercellactivationnaturalkillercellmediatedcytotoxicitynegativeregulationofGTPaseactivitynegativeregulationofnaturalkillercellchemotaxisnitricoxidebiosyntheticprocesspositiveregulationofinterferon-gammaproductionpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnitricoxidebiosyntheticprocesssignaltransductionstimulatoryC-typelectinreceptorsignalingpathwayTcellcostimulation
C-C motif chemokine 17
73
C-C motif chemokine 17
33
8.4
72
0.16
CCL17CCL17Q92583Q92583antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisnegativeregulationofmyoblastdifferentiationneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
Defensin alpha 4
67
Defensin alpha 4
82
4.2
79
0.3
DEF4DEF4P12838P12838antibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideantimicrobialhumoralresponsecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingofcellsofanotherorganismmembranedisruptioninanotherorganismTcellchemotaxis
S-phase kinase-associated protein 1
160
S-phase kinase-associated protein 2
113
8.6
nan
nan
SKP1SKP2P63208Q13309histoneH2AmonoubiquitinationmaintenanceofproteinlocationinnucleuspositiveregulationofubiquitinproteinligaseactivityproteinK48-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocessdefenseresponsetovirusG1/StransitionofmitoticcellcycleG2/Mtransitionofmitoticcellcycleinnateimmuneresponsepositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofproteinpolyubiquitinationproteasome-mediatedubiquitin-dependentproteincatabolicprocessregulationofapoptoticprocessregulationofcellcycle
Hepatocyte growth factor
206
Hepatocyte growth factor
206
4.7
56
0.38
HGFHGFP14210P14210animalorganregenerationcellchemotaxiscellmorphogenesiscellularresponsetohepatocytegrowthfactorstimulusepithelialcellproliferationepithelialtomesenchymaltransitionhepatocytegrowthfactorreceptorsignalingpathwayliverdevelopmentmitoticcellcyclemyoblastproliferationnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-6productionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofreleaseofcytochromecfrommitochondriapositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofinterleukin-10productionpositiveregulationofMAPKcascadepositiveregulationofmyelinationpositiveregulationofneuronprojectionregenerationpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofbranchinginvolvedinsalivaryglandmorphogenesisbymesenchymal-epithelialsignalingregulationofp38MAPKcascaderegulationoftau-proteinkinaseactivityskeletalmusclecellproliferation
Potassium voltage-gated channel subfamily B member 1
132
Potassium voltage-gated channel subfamily B member 1
111
3.6
46
0.6
KCNB1KCNB1Q14721Q14721actionpotentialcellularresponsetocalciumioncellularresponsetoglucosestimuluscellularresponsetonutrientlevelsclusteringofvoltage-gatedpotassiumchannelsglucosehomeostasisglutamatereceptorsignalingpathwaynegativeregulationofinsulinsecretionpositiveregulationofcalciumion-dependentexocytosispositiveregulationofcatecholaminesecretionpositiveregulationoflong-termsynapticdepressionpositiveregulationofnorepinephrinesecretionpositiveregulationofproteintargetingtomembranepotassiumionexportacrossplasmamembranepotassiumiontransmembranetransportproteinhomooligomerizationproteinlocalizationtoplasmamembraneregulationofactionpotentialregulationofiontransmembranetransportregulationofmotorneuronapoptoticprocessresponsetoaxoninjuryresponsetoL-glutamatevesicledockinginvolvedinexocytosis
Defensin alpha 5
82
Defensin alpha 5
67
3.8
77
0.34
DEF5DEF5Q01523Q01523antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismpositiveregulationofinterleukin-8productionpositiveregulationofmembranepermeabilityproteinhomotetramerization
Inhibin beta A chain
390
Inhibin beta A chain
354
8.4
54
0.22
INHBAINHBAP08476P08476activinreceptorsignalingpathwaycelldifferentiationcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularresponsetocholesterolcellularresponsetofollicle-stimulatinghormonestimulusdefenseresponseendodermalcelldifferentiationerythrocytedifferentiationextrinsicapoptoticsignalingpathwayeyeliddevelopmentincamera-typeeyeGABAergicneurondifferentiationhairfollicledevelopmenthematopoieticprogenitorcelldifferentiationhemoglobinbiosyntheticprocessmalegonaddevelopmentmesodermalcelldifferentiationmulticellularorganismagingnegativeregulationofBcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationoffollicle-stimulatinghormonesecretionnegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofinterferon-gammaproductionnegativeregulationofmacrophagedifferentiationnegativeregulationofphosphorylationnervoussystemdevelopmentodontogenesisovarianfollicledevelopmentpositiveregulationoferythrocytedifferentiationpositiveregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandpositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofgeneexpressionpositiveregulationofovulationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprogesteronesecretionregulationoffollicle-stimulatinghormonesecretionregulationoftranscriptionbyRNApolymeraseIIresponsetoxenobioticstimulusroofofmouthdevelopmentSMADproteinsignaltransductionstriatalmediumspinyneurondifferentiationtranscriptionbyRNApolymeraseII
Glutamate receptor 2
330
Glutamate receptor 2
78
9.2
71
0.15
GRIA2GRIA2P42262P42262chemicalsynaptictransmissionionotropicglutamatereceptorsignalingpathwaysignaltransductionsynaptictransmissionglutamatergic
Endothelin-1
53
Endothelin-1
63
3.7
56
0.48
EDN1EDN1P05305P05305adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayarterysmoothmusclecontractionaxonextensionaxonogenesisinvolvedininnervationbodyfluidsecretionbranchinginvolvedinbloodvesselmorphogenesiscalciumiontransmembranetransportcalcium-mediatedsignalingcanonicalWntsignalingpathwaycardiacneuralcrestcellmigrationinvolvedinoutflowtractmorphogenesiscartilagedevelopmentcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularcalciumionhomeostasiscellularresponsetocalciumioncellularresponsetofattyacidcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetohumanchorionicgonadotropinstimuluscellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoluteinizinghormonestimuluscellularresponsetomineralocorticoidstimuluscellularresponsetoorganicsubstancecellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetotumornecrosisfactorcellularresponsetoxenobioticstimulusdorsal/ventralpatternformationembryonichearttubedevelopmentendothelinreceptorsignalingpathwayendothelinreceptorsignalingpathwayinvolvedinheartprocessepithelialfluidtransportERK1andERK2cascadeGprotein-coupledreceptorsignalingpathwayhistaminesecretionI-kappaBkinase/NF-kappaBsignalinginuteroembryonicdevelopmentinositolphosphate-mediatedsignalingleukocyteactivationmaternalprocessinvolvedinparturitionmeioticcellcycleprocessinvolvedinoocytematurationmembranedepolarizationmiddleearmorphogenesismitochondrionorganizationmulticellularorganismagingnegativeregulationofbloodcoagulationnegativeregulationofgeneexpressionnegativeregulationofhormonesecretionnegativeregulationofnitric-oxidesynthasebiosyntheticprocessnegativeregulationofproteinmetabolicprocessnegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneuralcrestcellfatecommitmentnitricoxidetransportnoradrenergicneurondifferentiationpeptidehormonesecretionpharyngealarcharterymorphogenesisphosphatidylinositol3-kinasesignalingphospholipaseD-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcardiacmusclehypertrophypositiveregulationofcationchannelactivitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellsizepositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellmigrationpositiveregulationofheartratepositiveregulationofhormonesecretionpositiveregulationofJUNkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofmitoticnucleardivisionpositiveregulationofneutrophilchemotaxispositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofodontogenesispositiveregulationofprostaglandinsecretionpositiveregulationofprostaglandin-endoperoxidesynthaseactivitypositiveregulationofrenalsodiumexcretionpositiveregulationofsarcomereorganizationpositiveregulationofsignalingreceptoractivitypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsmoothmusclecontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofurinevolumepositiveregulationofvascularassociatedsmoothmusclecellproliferationprostaglandinbiosyntheticprocessproteinkinaseAsignalingproteinkinaseCdeactivationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteinphosphorylationregulationofglucosetransmembranetransportregulationofpHregulationofsensoryperceptionofpainregulationofsystemicarterialbloodpressurebyendothelinregulationofvasoconstrictionrenalsodiumionabsorptionrespiratorygaseousexchangebyrespiratorysystemresponsetoactivityresponsetoaminoacidresponsetoamphetamineresponsetodexamethasoneresponsetoleptinresponsetolipopolysaccharideresponsetomusclestretchresponsetonicotineresponsetoozoneresponsetoprostaglandinFresponsetosaltresponsetotestosteronerhythmicexcitationsemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesensoryperceptionofpainsuperoxideaniongenerationsympatheticneuronaxonguidancethyroidglanddevelopmenttranscriptionbyRNApolymeraseIIvasoconstrictionveinsmoothmusclecontraction
Defensin alpha 4
93
Defensin alpha 4
67
8.7
82
0.14
DEF4DEF4P12838P12838antibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideantimicrobialhumoralresponsecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingofcellsofanotherorganismmembranedisruptioninanotherorganismTcellchemotaxis
Dr1-associated corepressor
73
Protein Dr1
42
8.6
51
0.23
NC2ANC2BQ14919Q01658negativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedtranscriptionbyRNApolymeraseIIchromatinremodelinghistoneH3acetylationhistoneH3-K14acetylationregulationofcellcycleregulationofcelldivisionregulationofembryonicdevelopmentregulationofhistonedeacetylationregulationoftranscriptionbyRNApolymeraseIIregulationoftubulindeacetylationRNApolymeraseIIpreinitiationcomplexassembly
Defensin alpha 5
82
Defensin alpha 5
65
5.8
72
0.24
DEF5DEF5Q01523Q01523antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismpositiveregulationofinterleukin-8productionpositiveregulationofmembranepermeabilityproteinhomotetramerization
Histone-lysine N-methyltransferase 2C
1057
Histone-lysine N-methyltransferase 2C
1060
3.8
66
0.4
KMT2CKMT2CQ8NEZ4Q8NEZ4chromatinorganizationhistoneH3-K4methylationhistoneH3-K4monomethylationpositiveregulationoftranscriptionbyRNApolymeraseII
Potassium voltage-gated channel subfamily B member 1
133
Potassium voltage-gated channel subfamily B member 1
111
3.7
53
0.5
KCNB1KCNB1Q14721Q14721actionpotentialcellularresponsetocalciumioncellularresponsetoglucosestimuluscellularresponsetonutrientlevelsclusteringofvoltage-gatedpotassiumchannelsglucosehomeostasisglutamatereceptorsignalingpathwaynegativeregulationofinsulinsecretionpositiveregulationofcalciumion-dependentexocytosispositiveregulationofcatecholaminesecretionpositiveregulationoflong-termsynapticdepressionpositiveregulationofnorepinephrinesecretionpositiveregulationofproteintargetingtomembranepotassiumionexportacrossplasmamembranepotassiumiontransmembranetransportproteinhomooligomerizationproteinlocalizationtoplasmamembraneregulationofactionpotentialregulationofiontransmembranetransportregulationofmotorneuronapoptoticprocessresponsetoaxoninjuryresponsetoL-glutamatevesicledockinginvolvedinexocytosis
Bone morphogenetic protein 6
412
Bone morphogenetic protein 6
477
8.0
76
0.17
BMP6BMP6P22004P22004BMPsignalingpathwaycartilagedevelopmentcellularironionhomeostasiscellularresponsetoBMPstimuluscellularresponsetoironioncellularresponsetomechanicalstimulusendochondralossificationeyedevelopmentimmuneresponseinflammatoryresponsekidneydevelopmentmalegenitaliadevelopmentmulticellularorganismalironionhomeostasisnegativeregulationofadherensjunctionorganizationnegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationoftranscriptionbyRNApolymeraseIIneurondifferentiationosteoblastdifferentiationpositiveregulationofaldosteronebiosyntheticprocesspositiveregulationofaldosteronesecretionpositiveregulationofbonemineralizationpositiveregulationofcellpopulationproliferationpositiveregulationofchondrocytedifferentiationpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofgeneexpressionpositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofneurondifferentiationpositiveregulationofosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinsecretionpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularpermeabilityresponsetoactivityresponsetoglucocorticoidresponsetomagnesiumionresponsetoretinoicacidskeletalsystemdevelopmentSMADproteinsignaltransductiontypeBpancreaticcelldevelopment
Neutrophil defensin 1
94
Neutrophil defensin 1
68
6.9
nan
nan
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismmodificationbyhostofsymbiontmembraneTcellchemotaxis
Neuroblastoma suppressor of tumorigenicity 1
123
Neuroblastoma suppressor of tumorigenicity 1
123
4.2
62
0.38
NBL1NBL1P41271P41271animalorganmorphogenesisdeterminationofdorsalidentitynegativeregulationofBMPsignalingpathwaynegativeregulationofmonocytechemotaxisnervoussystemdevelopmentneuronprojectionmorphogenesispositiveregulationofneurondifferentiationsequesteringofBMPfromreceptorviaBMPbindingsequesteringofBMPinextracellularmatrix
Urokinase plasminogen activator surface receptor
98
Urokinase plasminogen activator surface receptor
25
5.5
60
0.3
UPARUPARQ03405Q03405bloodcoagulationchemotaxisnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaynegativeregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofDNAbindingpositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofhomotypiccell-celladhesionpositiveregulationofproteinphosphorylationpositiveregulationofreleaseofcytochromecfrommitochondriaregulationofcelladhesionregulationoffibrinolysisregulationofplasminogenactivationregulationofproteolysissignaltransductionurokinaseplasminogenactivatorsignalingpathway
Histone-lysine N-methyltransferase 2C
1081
Histone-lysine N-methyltransferase 2C
1057
7.6
70
0.19
KMT2CKMT2CQ8NEZ4Q8NEZ4chromatinorganizationhistoneH3-K4methylationhistoneH3-K4monomethylationpositiveregulationoftranscriptionbyRNApolymeraseII
Protein cereblon
346
Protein cereblon
329
8.4
44
0.27
CRBNCRBNQ8C7D2Q8C7D2locomotoryexplorationbehaviornegativeregulationofiontransmembranetransportnegativeregulationoflargeconductancecalcium-activatedpotassiumchannelactivitynegativeregulationofprotein-containingcomplexassemblypositiveregulationofprotein-containingcomplexassemblyproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitination
Serine/threonine-protein kinase 32A
340
Serine/threonine-protein kinase 32A
346
5.2
44
0.44
ST32AST32AQ8WU08Q8WU08intracellularsignaltransductionpeptidyl-serinephosphorylation
Neurogenic locus notch homolog protein 3
1500
Neurogenic locus notch homolog protein 3
1500
9.7
57
0.18
NOTC3NOTC3Q9UM47Q9UM47arterymorphogenesisaxonguidanceforebraindevelopmentglomerularcapillaryformationnegativeregulationofneurondifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIneuroblastdifferentiationneuronfatecommitmentNotchsignalingpathwaypositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseII
Neuroblastoma suppressor of tumorigenicity 1
82
Neuroblastoma suppressor of tumorigenicity 1
123
3.8
69
0.39
NBL1NBL1P41271P41271animalorganmorphogenesisdeterminationofdorsalidentitynegativeregulationofBMPsignalingpathwaynegativeregulationofmonocytechemotaxisnervoussystemdevelopmentneuronprojectionmorphogenesispositiveregulationofneurondifferentiationsequesteringofBMPfromreceptorviaBMPbindingsequesteringofBMPinextracellularmatrix
Insulin-like growth factor I
54
Insulin-like growth factor-binding protein 1
176
6.0
78
0.21
IGF1IBP1P05019P08833activationofproteinkinaseBactivitybonemineralizationinvolvedinbonematurationcellactivationcellpopulationproliferationcellularresponsetoamyloid-betaERK1andERK2cascadeglycolatemetabolicprocessinsulin-likegrowthfactorreceptorsignalingpathwaymusclehypertrophymuscleorgandevelopmentmyoblastdifferentiationmyoblastproliferationmyotubecelldevelopmentnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofinterleukin-1betaproductionnegativeregulationofneuroinflammatoryresponsenegativeregulationofoocytedevelopmentnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftumornecrosisfactorproductionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcardiacmusclehypertrophypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRasproteinsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftrophectodermalcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseBsignalingproteinstabilizationproteoglycanbiosyntheticprocessRasproteinsignaltransductionregulationofgeneexpressionregulationofmulticellularorganismgrowthregulationofproteinphosphorylationresponsetoheatsignaltransductionskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationskeletalsystemdevelopmentwoundhealingaginginsulinreceptorsignalingpathwaynegativeregulationofcanonicalWntsignalingpathwaypositiveregulationofcellgrowthregulationofinsulin-likegrowthfactorreceptorsignalingpathwaytissueregeneration
Glutamate receptor 3
85
Glutamate receptor 3
334
9.2
68
0.16
GRIA3GRIA3P19492P19492regulationofreceptorrecyclingresponsetofungicideresponsetolithiumion
GTP-binding protein GEM
209
GTP-binding protein GEM
106
9.7
61
0.17
GEMGEMP55040P55040cellsurfacereceptorsignalingpathwaychromosomeorganizationimmuneresponsemetaphaseplatecongressionmitoticcellcyclenegativeregulationofhighvoltage-gatedcalciumchannelactivitysignaltransduction
Glycoprotein hormones alpha chain
31
Follitropin subunit beta
50
7.0
60
0.24
Q96QJ4FSHBQ96QJ4P01225femalegametegenerationfemalepregnancyfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwaypositiveregulationofboneresorptionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationregulationofsignalingreceptoractivitySertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
C-type lectin domain family 2 member D
75
C-type lectin domain family 2 member D
86
10.0
71
0.14
CLC2DCLC2DQ9UHP7Q9UHP7cellsurfacereceptorsignalingpathway
Natural killer cells antigen CD94
59
NKG2-A/NKG2-B type II integral membrane protein
130
8.5
66
0.18
KLRD1NKG2AQ13241P26715adaptiveimmuneresponsecellsurfacereceptorsignalingpathwaynaturalkillercellmediatedimmunitynegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofTcellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicityregulationofnaturalkillercellactivationstimulatoryC-typelectinreceptorsignalingpathwayCD8-positivegamma-deltaintraepithelialTcelldifferentiationinnateimmuneresponsenaturalkillercellinhibitorysignalingpathway
PRSS3 protein
68
Amyloid-beta precursor protein
300
8.7
95
0.12
Q8N2U3A4Q8N2U3P05067proteolysisadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Defensin alpha 5
67
Defensin alpha 5
93
9.0
64
0.17
DEF5DEF5Q01523Q01523antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismpositiveregulationofinterleukin-8productionpositiveregulationofmembranepermeabilityproteinhomotetramerization
Glycoprotein hormones alpha chain
31
Follitropin subunit beta
69
9.9
64
0.16
Q96QJ4FSHBQ96QJ4P01225femalegametegenerationfemalepregnancyfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwaypositiveregulationofboneresorptionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationregulationofsignalingreceptoractivitySertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Kallikrein-6
63
Amyloid-beta precursor protein
300
8.4
97
0.12
KLK6A4Q92876P05067amyloidprecursorproteinmetabolicprocesscentralnervoussystemdevelopmentcollagencatabolicprocesshormonemetabolicprocessmyelinationpositiveregulationofGprotein-coupledreceptorsignalingpathwayproteinautoprocessingregulationofcelldifferentiationregulationofneuronprojectiondevelopmentresponsetowoundingtissueregenerationadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Cytosolic iron-sulfur assembly component 2A
155
Cytosolic iron-sulfur assembly component 2A
99
4.2
71
0.34
CIA2ACIA2AQ9H5X1Q9H5X1chromosomesegregationiron-sulfurclusterassemblyproteinmaturationby4Fe-4Sclustertransferproteinmaturationbyiron-sulfurclustertransfer
Defensin alpha 4
93
Defensin alpha 4
82
9.2
59
0.18
DEF4DEF4P12838P12838antibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideantimicrobialhumoralresponsecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingofcellsofanotherorganismmembranedisruptioninanotherorganismTcellchemotaxis
Low affinity immunoglobulin epsilon Fc receptor
160
Low affinity immunoglobulin epsilon Fc receptor
288
7.9
66
0.19
FCER2FCER2P06734P06734positiveregulationofhumoralimmuneresponsemediatedbycirculatingimmunoglobulinpositiveregulationofkillingofcellsofanotherorganismpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofnitric-oxidesynthasebiosyntheticprocess
Secreted frizzled-related protein 3
35
Secreted frizzled-related protein 3
96
8.6
62
0.19
SFRP3SFRP3P97401P97401canonicalWntsignalingpathwaycochleamorphogenesisconvergentextensioninvolvedinorganogenesisepithelialcelldevelopmenthepatocytedifferentiationinnerearmorphogenesisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcartilagedevelopmentnegativeregulationofcelldevelopmentnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofhepatocytedifferentiationnegativeregulationofWntsignalingpathwayneuralcrestcelldifferentiationpositiveregulationofapoptoticprocesspositiveregulationoffatcelldifferentiationsomitedevelopment
Copper homeostasis protein cutC homolog
248
Copper homeostasis protein cutC homolog
248
9.2
46
0.24
CUTCCUTCQ9NTM9Q9NTM9copperionhomeostasiscopperiontransportproteintetramerization
Platelet basic protein
105
Platelet basic protein
65
9.3
68
0.16
CXCL7CXCL7P02775P02775antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaydefenseresponsetobacteriumglucosetransmembranetransportinflammatoryresponsekillingofcellsofanotherorganismneutrophilchemotaxispositiveregulationofcelldivision
Fibrinogen alpha chain
68
Fibrinogen alpha chain
47
7.6
68
0.19
FIBAFIBAP02671P02671adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumion
S-phase kinase-associated protein 1
160
F-box/LRR-repeat protein 17
342
4.3
nan
nan
SKP1FXL17P63208Q9UF56histoneH2AmonoubiquitinationmaintenanceofproteinlocationinnucleuspositiveregulationofubiquitinproteinligaseactivityproteinK48-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocessentrainmentofcircadianclockbyphotoperiodG2/Mtransitionofmitoticcellcyclenervoussystemdevelopmentneuralcrestcelldifferentiationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinqualitycontrolformisfoldedorincompletelysynthesizedproteinsregulationofcellcycleregulationofsmoothenedsignalingpathway
C-C motif chemokine 17
33
C-C motif chemokine 17
33
7.9
78
0.16
CCL17CCL17Q92583Q92583antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisnegativeregulationofmyoblastdifferentiationneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
Glycoprotein hormones alpha chain
31
Follitropin subunit beta
69
9.9
60
0.17
GLHAFSHBP01215P01225follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationfemalegametegenerationfemalepregnancypositiveregulationofboneresorptionpositiveregulationofgeneexpressionprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationSertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Aldo-keto reductase family 1 member C2
7
Aldo-keto reductase family 1 member C2
7
8.4
76
0.16
AK1C2AK1C2P52895P52895cellularresponsetojasmonicacidstimuluscellularresponsetoprostaglandinDstimulusdaunorubicinmetabolicprocessdigestiondoxorubicinmetabolicprocessepithelialcelldifferentiationGprotein-coupledreceptorsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofproteinkinaseBsignalingprogesteronemetabolicprocessprostaglandinmetabolicprocesssteroidmetabolicprocess
Defensin-6
72
Defensin-6
99
5.3
68
0.28
DEF6DEF6Q01524Q01524antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosakillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Defensin alpha 5
67
Defensin alpha 5
67
4.2
84
0.28
DEF5DEF5Q01523Q01523antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismpositiveregulationofinterleukin-8productionpositiveregulationofmembranepermeabilityproteinhomotetramerization
C-type lectin domain family 4 member M
265
C-type lectin domain family 4 member M
395
9.3
47
0.23
CLC4MCLC4MQ9H2X3Q9H2X3adaptiveimmuneresponseantigenprocessingandpresentationcell-cellrecognitioninnateimmuneresponseintracellularsignaltransductionintracellulartransportofvirusleukocytecell-celladhesionpeptideantigentransportreceptor-mediatedendocytosisofvirusbyhostcellreceptor-mediatedvirionattachmenttohostcellviralentryintohostcellviralgenomereplicationvirionattachmenttohostcell
Neuroblastoma suppressor of tumorigenicity 1
82
Neuroblastoma suppressor of tumorigenicity 1
82
4.3
75
0.31
NBL1NBL1P41271P41271animalorganmorphogenesisdeterminationofdorsalidentitynegativeregulationofBMPsignalingpathwaynegativeregulationofmonocytechemotaxisnervoussystemdevelopmentneuronprojectionmorphogenesispositiveregulationofneurondifferentiationsequesteringofBMPfromreceptorviaBMPbindingsequesteringofBMPinextracellularmatrix
Histone-lysine N-methyltransferase 2C
1057
Histone-lysine N-methyltransferase 2C
1069
7.6
65
0.2
KMT2CKMT2CQ8NEZ4Q8NEZ4chromatinorganizationhistoneH3-K4methylationhistoneH3-K4monomethylationpositiveregulationoftranscriptionbyRNApolymeraseII
Platelet-derived growth factor subunit B
180
Platelet-derived growth factor subunit B
124
9.2
56
0.2
PDGFBPDGFBP01127P01127activationofproteinkinaseactivityactivationofproteinkinaseBactivitycellchemotaxiscellularresponsetogrowthfactorstimuluscellularresponsetomycophenolicacidcellularresponsetoplatelet-derivedgrowthfactorstimulusembryonicplacentadevelopmentheartdevelopmentinterleukin-18-mediatedsignalingpathwaymetanephricglomerularmesangialcelldevelopmentmonocytechemotaxisnegativeregulationofgeneexpressionnegativeregulationofmiRNAtranscriptionnegativeregulationofphosphatidylinositolbiosyntheticprocessnegativeregulationofplateletactivationnegativeregulationofproteinbindingnegativeregulationoftranscriptionDNA-templatednegativeregulationofvascularassociatedsmoothmusclecelldifferentiationparacrinesignalingpeptidyl-serinephosphorylationpeptidyl-tyrosinephosphorylationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcalciumionimportpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-substrateadhesionpositiveregulationofchemotaxispositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglomerularfiltrationpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofhyaluronanbiosyntheticprocesspositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmetanephricmesenchymalcellmigrationpositiveregulationofmetanephricmesenchymalcellmigrationbyplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofmiRNAtranscriptionpositiveregulationofmitoticnucleardivisionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularassociatedsmoothmusclecelldedifferentiationpositiveregulationofvascularassociatedsmoothmusclecellmigrationpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseCsignalingproteinphosphorylationreactiveoxygenspeciesmetabolicprocessresponsetowounding
F-box only protein 11
868
F-box only protein 11
899
3.7
55
0.5
FBX11FBX11Q86XK2Q86XK2proteinmodificationprocessproteinubiquitinationregulationofapoptoticprocesssensoryperceptionofsoundubiquitin-dependentproteincatabolicprocess
Interleukin-6 receptor subunit alpha
176
Interleukin-6 receptor subunit alpha
132
6.4
74
0.21
IL6RAIL6RAP08887P08887acute-phaseresponseciliaryneurotrophicfactor-mediatedsignalingpathwaycytokine-mediatedsignalingpathwaydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumendocrinepancreasdevelopmentextrinsicapoptoticsignalingpathwayhepaticimmuneresponseinterleukin-6-mediatedsignalingpathwaymonocytechemotaxisnegativeregulationofcollagenbiosyntheticprocessnegativeregulationofinterleukin-8productionneutrophilmediatedimmunitypositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcellpopulationproliferationpositiveregulationofchemokineproductionpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofinterleukin-6productionpositiveregulationofleukocytechemotaxispositiveregulationofMAPKcascadepositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofplateletaggregationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinresponsetocytokineT-helper17celllineagecommitmentvascularendothelialgrowthfactorproduction
Annexin A2
9
Protein S100-A4
3
9.6
59
0.18
ANXA2S10A4P07355P26447angiogenesiscollagenfibrilorganizationfibrinolysismembraneraftassemblymRNAtranscriptionbyRNApolymeraseIInegativeregulationoflow-densitylipoproteinparticlereceptorcatabolicprocessnegativeregulationofreceptorinternalizationosteoclastdevelopmentpositiveregulationofexocytosispositiveregulationoflow-densitylipoproteinparticleclearancepositiveregulationoflow-densitylipoproteinparticlereceptorbindingpositiveregulationoflow-densitylipoproteinreceptoractivitypositiveregulationofplasmamembranerepairpositiveregulationofplasminogenactivationpositiveregulationofreceptorrecyclingpositiveregulationofreceptor-mediatedendocytosisinvolvedincholesteroltransportpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvacuoleorganizationpositiveregulationofvesiclefusionregulationofneurogenesisvesiclebuddingfrommembraneepithelialtomesenchymaltransitionpositiveregulationofI-kappaBkinase/NF-kappaBsignaling
Estrogen receptor
221
Estrogen receptor
227
6.9
61
0.24
ESR1ESR1P03372P03372androgenmetabolicprocessantralovarianfolliclegrowthcellularresponsetoestradiolstimuluscellularresponsetoestrogenstimuluschromatinremodelingepithelialcelldevelopmentepithelialcellproliferationinvolvedinmammaryglandductelongationfibroblastproliferationintracellularestrogenreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaymalegonaddevelopmentmammaryglandalveolusdevelopmentmammaryglandbranchinginvolvedinpregnancynegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofgeneexpressionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofmiRNAmaturationnegativeregulationoftranscriptionbyRNApolymeraseIIphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoffibroblastproliferationpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofphospholipaseCactivitypositiveregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprostateepithelialcordarborizationinvolvedinprostateglandularacinusmorphogenesisprostateepithelialcordelongationproteinlocalizationtochromatinregulationofbranchinginvolvedinprostateglandmorphogenesisregulationofepithelialcellapoptoticprocessregulationofinflammatoryresponseregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetoestradiolresponsetoestrogensignaltransductionstemcelldifferentiationtranscriptionbyRNApolymeraseIIuterusdevelopmentvaginadevelopment
Neurogenic locus notch homolog protein 3
1500
Neurogenic locus notch homolog protein 3
1484
7.9
57
0.22
NOTC3NOTC3Q9UM47Q9UM47arterymorphogenesisaxonguidanceforebraindevelopmentglomerularcapillaryformationnegativeregulationofneurondifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIneuroblastdifferentiationneuronfatecommitmentNotchsignalingpathwaypositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseII
F-box only protein 11
865
F-box only protein 11
899
6.9
57
0.26
FBX11FBX11Q86XK2Q86XK2proteinmodificationprocessproteinubiquitinationregulationofapoptoticprocesssensoryperceptionofsoundubiquitin-dependentproteincatabolicprocess
Glycoprotein hormones alpha chain
31
Follitropin subunit beta
102
6.7
54
0.28
Q96QJ4FSHBQ96QJ4P01225femalegametegenerationfemalepregnancyfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwaypositiveregulationofboneresorptionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationregulationofsignalingreceptoractivitySertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Nitric oxide synthase, endothelial
96
Nitric oxide synthase, endothelial
96
4.3
66
0.35
NOS3NOS3P29473P29473argininecatabolicprocessbloodcoagulationcellularresponsetolaminarfluidshearstressmitochondrionorganizationnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofleukocytecell-celladhesionnitricoxidebiosyntheticprocesspositiveregulationofguanylatecyclaseactivity
Trypsin
181
Trypsin
181
6.4
82
0.19
TRYPTRYPP00761P00761digestionproteolysis
Fibrinogen beta chain
87
Fibrinogen gamma-B chain
32
7.7
65
0.2
FIBBFIBGP02676P12799adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioninnateimmuneresponseplateletaggregationproteinpolymerization
Fractalkine
36
Fractalkine
32
9.0
61
0.18
X3CL1X3CL1P78423P78423agingangiogenesisinvolvedinwoundhealingautocrinesignalingcelladhesioncellchemotaxiscell-celladhesioncell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytokine-mediatedsignalingpathwaydefenseresponseeosinophilchemotaxisextrinsicapoptoticsignalingpathwayinabsenceofligandGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseintegrinactivationleukocyteadhesiveactivationleukocytechemotaxisleukocytemigrationinvolvedininflammatoryresponselymphocytechemotaxismicroglialcellactivationmicroglialcellproliferationmonocytechemotaxisnegativeregulationofapoptoticprocessnegativeregulationofapoptoticsignalingpathwaynegativeregulationofcellmigrationnegativeregulationofcell-substrateadhesionnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofglutamatereceptorsignalingpathwaynegativeregulationofhippocampalneuronapoptoticprocessnegativeregulationofinterleukin-1alphaproductionnegativeregulationofinterleukin-1betaproductionnegativeregulationofinterleukin-6productionnegativeregulationofmicroglialcellactivationnegativeregulationofneuronmigrationnegativeregulationoftumornecrosisfactorproductionneuroncellularhomeostasisneuronremodelingneutrophilchemotaxispositivechemotaxispositiveregulationofactinfilamentbundleassemblypositiveregulationofcalcium-independentcell-celladhesionpositiveregulationofcellpopulationproliferationpositiveregulationofcell-matrixadhesionpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofI-kappaBphosphorylationpositiveregulationofinflammatoryresponsepositiveregulationofMAPKcascadepositiveregulationofmicroglialcellmigrationpositiveregulationofneuroblastproliferationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftransforminggrowthfactorbeta1productionregulationoflipopolysaccharide-mediatedsignalingpathwayregulationofneurogenesisregulationofsynapticplasticityresponsetoischemiasynapsepruning
Neutrophil defensin 3
83
Neutrophil defensin 3
83
4.4
70
0.33
DEF3DEF3P59666P59666antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetovirusinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Endothelin-1
55
Endothelin-1
55
9.9
54
0.19
EDN1EDN1P05305P05305adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayarterysmoothmusclecontractionaxonextensionaxonogenesisinvolvedininnervationbodyfluidsecretionbranchinginvolvedinbloodvesselmorphogenesiscalciumiontransmembranetransportcalcium-mediatedsignalingcanonicalWntsignalingpathwaycardiacneuralcrestcellmigrationinvolvedinoutflowtractmorphogenesiscartilagedevelopmentcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularcalciumionhomeostasiscellularresponsetocalciumioncellularresponsetofattyacidcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetohumanchorionicgonadotropinstimuluscellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoluteinizinghormonestimuluscellularresponsetomineralocorticoidstimuluscellularresponsetoorganicsubstancecellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetotumornecrosisfactorcellularresponsetoxenobioticstimulusdorsal/ventralpatternformationembryonichearttubedevelopmentendothelinreceptorsignalingpathwayendothelinreceptorsignalingpathwayinvolvedinheartprocessepithelialfluidtransportERK1andERK2cascadeGprotein-coupledreceptorsignalingpathwayhistaminesecretionI-kappaBkinase/NF-kappaBsignalinginuteroembryonicdevelopmentinositolphosphate-mediatedsignalingleukocyteactivationmaternalprocessinvolvedinparturitionmeioticcellcycleprocessinvolvedinoocytematurationmembranedepolarizationmiddleearmorphogenesismitochondrionorganizationmulticellularorganismagingnegativeregulationofbloodcoagulationnegativeregulationofgeneexpressionnegativeregulationofhormonesecretionnegativeregulationofnitric-oxidesynthasebiosyntheticprocessnegativeregulationofproteinmetabolicprocessnegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneuralcrestcellfatecommitmentnitricoxidetransportnoradrenergicneurondifferentiationpeptidehormonesecretionpharyngealarcharterymorphogenesisphosphatidylinositol3-kinasesignalingphospholipaseD-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcardiacmusclehypertrophypositiveregulationofcationchannelactivitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellsizepositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellmigrationpositiveregulationofheartratepositiveregulationofhormonesecretionpositiveregulationofJUNkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofmitoticnucleardivisionpositiveregulationofneutrophilchemotaxispositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofodontogenesispositiveregulationofprostaglandinsecretionpositiveregulationofprostaglandin-endoperoxidesynthaseactivitypositiveregulationofrenalsodiumexcretionpositiveregulationofsarcomereorganizationpositiveregulationofsignalingreceptoractivitypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsmoothmusclecontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofurinevolumepositiveregulationofvascularassociatedsmoothmusclecellproliferationprostaglandinbiosyntheticprocessproteinkinaseAsignalingproteinkinaseCdeactivationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteinphosphorylationregulationofglucosetransmembranetransportregulationofpHregulationofsensoryperceptionofpainregulationofsystemicarterialbloodpressurebyendothelinregulationofvasoconstrictionrenalsodiumionabsorptionrespiratorygaseousexchangebyrespiratorysystemresponsetoactivityresponsetoaminoacidresponsetoamphetamineresponsetodexamethasoneresponsetoleptinresponsetolipopolysaccharideresponsetomusclestretchresponsetonicotineresponsetoozoneresponsetoprostaglandinFresponsetosaltresponsetotestosteronerhythmicexcitationsemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesensoryperceptionofpainsuperoxideaniongenerationsympatheticneuronaxonguidancethyroidglanddevelopmenttranscriptionbyRNApolymeraseIIvasoconstrictionveinsmoothmusclecontraction
Beta-nerve growth factor
231
Beta-nerve growth factor
231
7.7
87
0.15
NGFNGFP01138P01138activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsmemorymodulationofchemicalsynaptictransmissionnegativeregulationofcellpopulationproliferationnegativeregulationofneuronapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwayneuronapoptoticprocessneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofcollateralsproutingpositiveregulationofDNAbindingpositiveregulationofgeneexpressionpositiveregulationofneurondifferentiationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofRasproteinsignaltransductionregulationofneurondifferentiationtransmembranereceptorproteintyrosinekinasesignalingpathway
Cartilage oligomeric matrix protein
68
Cartilage oligomeric matrix protein
68
9.2
56
0.19
COMPCOMPP35444P35444apoptoticprocessarterymorphogenesisbloodcoagulationBMPsignalingpathwaybonegrowthbonemineralizationbonemorphogenesiscartilagedevelopmentcartilagehomeostasischondrocytedevelopmentchondrocyteproliferationcollagenfibrilorganizationendochondralbonegrowthgrowthplatecartilagedevelopmentlimbdevelopmentmulticellularorganismagingmulticellularorganismgrowthmusclecelldevelopmentmusculoskeletalmovementnegativeregulationofapoptoticprocessnegativeregulationofhemostasisneuromuscularprocessossificationplateletaggregationpositiveregulationofchondrocyteproliferationproteinhomooligomerizationproteinprocessingproteinsecretionregulationofbonemineralizationregulationofgeneexpressionresponsetounfoldedproteinskeletalsystemdevelopmentskindevelopmenttendondevelopmentvascularassociatedsmoothmusclecelldevelopmentvascularassociatedsmoothmusclecontraction
Proprotein convertase subtilisin/kexin type 9
378
Low-density lipoprotein receptor
318
7.7
81
0.16
PCSK9LDLRQ8NBP7P01130apoptoticprocesscellularresponsetoinsulinstimuluscellularresponsetostarvationcholesterolhomeostasischolesterolmetabolicprocesskidneydevelopmentlipoproteinmetabolicprocessliverdevelopmentlow-densitylipoproteinparticlereceptorcatabolicprocesslysosomaltransportnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationoflow-densitylipoproteinparticlereceptorbindingnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofreceptorinternalizationnegativeregulationofreceptorrecyclingnegativeregulationofreceptor-mediatedendocytosisinvolvedincholesteroltransportnegativeregulationofsodiumiontransmembranetransporteractivityneurogenesisneurondifferentiationphospholipidmetabolicprocesspositiveregulationoflow-densitylipoproteinparticlereceptorcatabolicprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofreceptorinternalizationproteinautoprocessingregulationofneuronapoptoticprocessregulationofsignalingreceptoractivitytriglyceridemetabolicprocessamyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessarterymorphogenesiscellularresponsetofattyacidcellularresponsetolow-densitylipoproteinparticlestimuluscholesterolimportcholesteroltransportendocytosishigh-densitylipoproteinparticleclearanceintestinalcholesterolabsorptionlipidmetabolicprocesslipoproteincatabolicprocesslong-termmemorylow-densitylipoproteinparticleclearancenegativeregulationofamyloidfibrilformationnegativeregulationofastrocyteactivationnegativeregulationofgeneexpressionnegativeregulationofmicroglialcellactivationnegativeregulationofproteinmetabolicprocessphagocytosisphospholipidtransportplasmalipoproteinparticleclearancepositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationoflysosomalproteincatabolicprocesspositiveregulationoftriglyceridebiosyntheticprocessreceptor-mediatedendocytosisreceptor-mediatedendocytosisinvolvedincholesteroltransportregulationofcholesterolmetabolicprocessregulationofphosphatidylcholinecatabolicprocessregulationofproteinmetabolicprocessresponsetocaloricrestriction
Hepatocyte growth factor
207
Hepatocyte growth factor
129
4.3
70
0.33
HGFHGFQ08048Q08048animalorganregenerationcellchemotaxiscellmorphogenesiscellularresponsetohepatocytegrowthfactorstimulusepithelialcellproliferationhepatocytegrowthfactorreceptorsignalingpathwayliverdevelopmentmyoblastproliferationnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-6productionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofreleaseofcytochromecfrommitochondriapositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofinterleukin-10productionpositiveregulationofMAPKcascadepositiveregulationofmyelinationpositiveregulationofneuronprojectionregenerationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationproteolysisregulationofbranchinginvolvedinsalivaryglandmorphogenesisbymesenchymal-epithelialsignalingregulationofp38MAPKcascaderegulationoftau-proteinkinaseactivityskeletalmusclecellproliferation
Interleukin-17A
146
Interleukin-17A
146
7.8
94
0.14
IL17IL17Q16552Q16552adaptiveimmuneresponseapoptoticprocesscelldeathcell-cellsignalingcellularresponsetointerleukin-1defenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumfibroblastactivationgranulocytemigrationimmuneresponseinflammatoryresponseinnateimmuneresponseinterleukin-17-mediatedsignalingpathwayintestinalepithelialstructuremaintenanceNotchsignalingpathwaypositiveregulationofantimicrobialpeptideproductionpositiveregulationofbicellulartightjunctionassemblypositiveregulationofchemokine(C-X-Cmotif)ligand1productionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-16productionpositiveregulationofinterleukin-23productionpositiveregulationofinterleukin-6productionpositiveregulationofosteoclastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproduction
Nitric oxide synthase, endothelial
101
Nitric oxide synthase, endothelial
101
4.4
83
0.28
NOS3NOS3P29473P29473argininecatabolicprocessbloodcoagulationcellularresponsetolaminarfluidshearstressmitochondrionorganizationnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofleukocytecell-celladhesionnitricoxidebiosyntheticprocesspositiveregulationofguanylatecyclaseactivity
Platelet factor 4
67
Platelet factor 4
67
8.1
76
0.16
PLF4PLF4P02777P02777adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaycytokine-mediatedsignalingpathwayinflammatoryresponseleukocytechemotaxisnegativeregulationofangiogenesisnegativeregulationofmegakaryocytedifferentiationneutrophilchemotaxisplateletactivationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellpopulationproliferation
Neutrophil defensin 1
94
Neutrophil defensin 1
94
9.4
nan
nan
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismmodificationbyhostofsymbiontmembraneTcellchemotaxis
Defensin alpha 5
93
Defensin alpha 5
93
7.7
65
0.2
DEF5DEF5Q01523Q01523antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismpositiveregulationofinterleukin-8productionpositiveregulationofmembranepermeabilityproteinhomotetramerization
Growth/differentiation factor 2
327
Growth/differentiation factor 2
392
9.2
75
0.15
GDF2GDF2Q9UK05Q9UK05activinreceptorsignalingpathwayangiogenesisbloodvesselmorphogenesisBMPsignalingpathwaybranchinginvolvedinbloodvesselmorphogenesiscartilagedevelopmentcellularironionhomeostasiscellularresponsetoBMPstimulusnegativeregulationofangiogenesisnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellgrowthnegativeregulationofDNAbiosyntheticprocessnegativeregulationofDNAreplicationnegativeregulationofendothelialcellmigrationnegativeregulationofendothelialcellproliferationossificationosteoblastdifferentiationpathway-restrictedSMADproteinphosphorylationpositiveregulationofangiogenesispositiveregulationofBMPsignalingpathwaypositiveregulationofcartilagedevelopmentpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofinterleukin-8productionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedSMADproteinsignaltransductiontranscriptionbyRNApolymeraseIIvasculogenesis
cAMP-dependent protein kinase
200
cAMP-dependent protein kinase type II-beta regulatory subunit
114
4.8
68
0.3
A1L1M0KAP3A1L1M0P31324proteinphosphorylationfattyacidmetabolicprocesslearningmodulationofchemicalsynaptictransmissionnegativeregulationofcAMP-dependentproteinkinaseactivityregulationofproteinkinaseactivityresponsetoantipsychoticdrugresponsetoclozapine
Cyanocobalamin reductase / alkylcobalamin dealkylase
70
Cyanocobalamin reductase / alkylcobalamin dealkylase
70
4.3
42
0.55
MMACMMACQ9Y4U1Q9Y4U1cobalaminmetabolicprocessdemethylationglutathionemetabolicprocess
Tyrosine-protein kinase JAK2
125
Erythropoietin receptor
314
7.7
67
0.19
JAK2EPORO60674P19235actinfilamentpolymerizationactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwayactivationofJanuskinaseactivityadaptiveimmuneresponseapoptoticprocessaxonregenerationcelldifferentiationcellularresponsetodexamethasonestimuluscellularresponsetointerleukin-3cellularresponsetolipopolysaccharidecellularresponsetoviruschromatinorganizationcollagen-activatedsignalingpathwaycytokine-mediatedsignalingpathwayenzyme-linkedreceptorproteinsignalingpathwayerythrocytedifferentiationextrinsicapoptoticsignalingpathwayGprotein-coupledreceptorsignalingpathwaygranulocyte-macrophagecolony-stimulatingfactorsignalingpathwaygrowthhormonereceptorsignalingpathwaygrowthhormonereceptorsignalingpathwayviaJAK-STATimmuneresponseinterferon-gamma-mediatedsignalingpathwayinterleukin-12-mediatedsignalingpathwayinterleukin-35-mediatedsignalingpathwayinterleukin-6-mediatedsignalingpathwayintracellularsignaltransductionintrinsicapoptoticsignalingpathwayinresponsetooxidativestressmammaryglandepitheliumdevelopmentmesodermdevelopmentmicroglialcellactivationmineralocorticoidreceptorsignalingpathwaymodulationofchemicalsynaptictransmissionnegativeregulationofcardiacmusclecellapoptoticprocessnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofDNAbindingnegativeregulationofheartcontractionnegativeregulationofneuronapoptoticprocesspeptidyl-tyrosinephosphorylationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofapoptoticsignalingpathwaypositiveregulationofcelldifferentiationpositiveregulationofcellmigrationpositiveregulationofcell-substrateadhesionpositiveregulationofcold-inducedthermogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNAbindingpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofepithelialcellapoptoticprocesspositiveregulationofgrowthfactordependentskeletalmusclesatellitecellproliferationpositiveregulationofgrowthhormonereceptorsignalingpathwaypositiveregulationofinflammatoryresponsepositiveregulationofinsulinsecretionpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-17productionpositiveregulationofleukocyteproliferationpositiveregulationofMAPKcascadepositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofnaturalkillercellproliferationpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofNKTcellproliferationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphoproteinphosphataseactivitypositiveregulationofplateletactivationpositiveregulationofplateletaggregationpositiveregulationofproteinimportintonucleuspositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsignalingreceptoractivitypositiveregulationofSMADproteinsignaltransductionpositiveregulationofTcellproliferationpositiveregulationofT-helper17typeimmuneresponsepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationpost-embryonichemopoiesispost-translationalproteinmodificationpostsynapsetonucleussignalingpathwayprogrammedcelldeathinducedbysymbiontproteinautophosphorylationproteinphosphorylationreceptorsignalingpathwayviaJAK-STATregulationofapoptoticprocessregulationofinflammatoryresponseregulationofnitricoxidebiosyntheticprocessregulationofreceptorsignalingpathwayviaJAK-STATresponsetoamineresponsetoantibioticresponsetohydroperoxideresponsetointerleukin-12responsetolipopolysaccharideresponsetotumornecrosisfactorsignaltransductiontranscriptionbyRNApolymeraseIItumornecrosisfactor-mediatedsignalingpathwaytyrosinephosphorylationofSTATproteinbraindevelopmentdecidualizationheartdevelopmenthemopoiesispositiveregulationofcellpopulationproliferation
Trypsin-3
105
Tissue factor pathway inhibitor
63
9.2
98
0.11
TRY3TFPI1P35030P10646antimicrobialhumoralresponsedigestionendothelialcellmigrationproteolysiszymogenactivationbloodcoagulationcellularresponsetosteroidhormonestimulusnegativeregulationofbloodcoagulation
RNA 5'-monophosphate methyltransferase
249
RNA 5'-monophosphate methyltransferase
248
6.5
80
0.19
BN3D2BN3D2Q7Z5W3Q7Z5W3miRNAmetabolicprocessnegativeregulationofpre-miRNAprocessingpre-miRNAprocessingRNAmethylationtRNAmethylation
NAD kinase
349
NAD kinase
349
4.3
83
0.28
NADKNADKO95544O95544ATPmetabolicprocessNADmetabolicprocessNADPbiosyntheticprocessphosphorylation
Proteasome subunit beta type-7
74
Proteasome subunit beta type-3
129
7.7
70
0.19
PSB7PSB3P70195Q9R1P1proteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteincatabolicprocess
Bone marrow stromal antigen 2
91
Bone marrow stromal antigen 2
91
4.5
50
0.45
BST2BST2Q10589Q10589BcellactivationdefenseresponsetovirusinnateimmuneresponsenegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofintracellulartransportofviralmaterialnegativeregulationofplasmacytoiddendriticcellcytokineproductionnegativeregulationofviralgenomereplicationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofleukocyteproliferationregulationofactincytoskeletonorganizationresponsetointerferon-alpharesponsetointerferon-betaresponsetointerferon-gammaresponsetovirus
Protein bicaudal D homolog 1
752
Protein bicaudal D homolog 1
752
4.8
46
0.45
BICD1BICD1Q8BR07Q8BR07microtubuleanchoringatmicrotubuleorganizingcenterminus-end-directedorganelletransportalongmicrotubulenegativeregulationofphospholipaseCactivitynegativeregulationofphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtocentrosomepositiveregulationofreceptor-mediatedendocytosisproteinlocalizationtoorganelleregulationofmicrotubulecytoskeletonorganizationregulationofproteinaseactivatedreceptoractivitystressgranuleassemblyviralprocess
Defensin alpha 4
82
Defensin alpha 4
82
6.5
77
0.2
DEF4DEF4P12838P12838antibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideantimicrobialhumoralresponsecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingofcellsofanotherorganismmembranedisruptioninanotherorganismTcellchemotaxis
Natural killer cells antigen CD94
70
NKG2-A/NKG2-B type II integral membrane protein
116
7.8
59
0.22
KLRD1NKG2AQ13241P26715adaptiveimmuneresponsecellsurfacereceptorsignalingpathwaynaturalkillercellmediatedimmunitynegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofTcellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicityregulationofnaturalkillercellactivationstimulatoryC-typelectinreceptorsignalingpathwayCD8-positivegamma-deltaintraepithelialTcelldifferentiationinnateimmuneresponsenaturalkillercellinhibitorysignalingpathway
Hepatocyte growth factor
212
Hepatocyte growth factor
212
6.5
88
0.17
HGFHGFQ08048Q08048animalorganregenerationcellchemotaxiscellmorphogenesiscellularresponsetohepatocytegrowthfactorstimulusepithelialcellproliferationhepatocytegrowthfactorreceptorsignalingpathwayliverdevelopmentmyoblastproliferationnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-6productionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofreleaseofcytochromecfrommitochondriapositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofinterleukin-10productionpositiveregulationofMAPKcascadepositiveregulationofmyelinationpositiveregulationofneuronprojectionregenerationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationproteolysisregulationofbranchinginvolvedinsalivaryglandmorphogenesisbymesenchymal-epithelialsignalingregulationofp38MAPKcascaderegulationoftau-proteinkinaseactivityskeletalmusclecellproliferation
Defensin alpha 5
67
Defensin alpha 5
92
9.2
nan
nan
DEF5DEF5Q01523Q01523antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismpositiveregulationofinterleukin-8productionpositiveregulationofmembranepermeabilityproteinhomotetramerization
Amyloid beta precursor like protein 2
310
Amyloid beta precursor like protein 2
335
5.8
60
0.29
APLP2APLP2Q06481Q06481axonogenesiscentralnervoussystemdevelopmentGprotein-coupledreceptorsignalingpathwayregulationofcellularproteinmetabolicprocess
Estrogen receptor
221
Estrogen receptor
221
9.4
59
0.18
ESR1ESR1P03372P03372androgenmetabolicprocessantralovarianfolliclegrowthcellularresponsetoestradiolstimuluscellularresponsetoestrogenstimuluschromatinremodelingepithelialcelldevelopmentepithelialcellproliferationinvolvedinmammaryglandductelongationfibroblastproliferationintracellularestrogenreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaymalegonaddevelopmentmammaryglandalveolusdevelopmentmammaryglandbranchinginvolvedinpregnancynegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofgeneexpressionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofmiRNAmaturationnegativeregulationoftranscriptionbyRNApolymeraseIIphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoffibroblastproliferationpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofphospholipaseCactivitypositiveregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprostateepithelialcordarborizationinvolvedinprostateglandularacinusmorphogenesisprostateepithelialcordelongationproteinlocalizationtochromatinregulationofbranchinginvolvedinprostateglandmorphogenesisregulationofepithelialcellapoptoticprocessregulationofinflammatoryresponseregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetoestradiolresponsetoestrogensignaltransductionstemcelldifferentiationtranscriptionbyRNApolymeraseIIuterusdevelopmentvaginadevelopment
Rap1 GTPase-GDP dissociation stimulator 1
117
Transforming protein RhoA
190
6.8
65
0.23
GDS1RHOAP52306P61586angiotensin-activatedsignalingpathwayinvolvedinheartprocessCAAX-boxproteinmaturationcardiacmusclehypertrophymyosinfilamentassemblynegativeregulationofendoplasmicreticulumcalciumionconcentrationnegativeregulationofGTPaseactivitypositiveregulationofGTPaseactivitypositiveregulationofmitochondrialcalciumionconcentrationproteinlocalizationtonucleusregulationofERK5cascaderegulationofmatrixmetallopeptidasesecretionregulationofmitochondrionorganizationvascularassociatedsmoothmusclecontractionactincytoskeletonorganizationactincytoskeletonreorganizationactinfilamentorganizationalpha-betaTcelllineagecommitmentandrogenreceptorsignalingpathwayangiotensin-mediatedvasoconstrictioninvolvedinregulationofsystemicarterialbloodpressureapicaljunctionassemblyapolipoproteinA-I-mediatedsignalingpathwaybetaselectioncelljunctionassemblycellmigrationcell-matrixadhesioncellularresponsetochemokinecellularresponsetocytokinestimuluscellularresponsetolipopolysaccharidecerebralcortexcellmigrationcleavagefurrowformationcorticalcytoskeletonorganizationcytoplasmicmicrotubuleorganizationendothelialcellmigrationendothelialtubelumenextensionestablishmentofepithelialcellapical/basalpolarityestablishmentormaintenanceofcellpolarityforebrainradialglialcelldifferentiationGTPmetabolicprocesskidneydevelopmentmitoticcleavagefurrowformationmitoticspindleassemblymotorneuronapoptoticprocessnegativechemotaxisnegativeregulationofcellmigrationinvolvedinsproutingangiogenesisnegativeregulationofcellsizenegativeregulationofcell-substrateadhesionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofintracellularsteroidhormonereceptorsignalingpathwaynegativeregulationofmotorneuronapoptoticprocessnegativeregulationofneurondifferentiationnegativeregulationofneuronprojectiondevelopmentnegativeregulationofoxidativephosphorylationnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofvascularassociatedsmoothmusclecellmigrationnegativeregulationofvascularassociatedsmoothmusclecellproliferationneuronmigrationneuronprojectionmorphogenesisodontogenesisossificationinvolvedinbonematurationpositiveregulationofactinfilamentpolymerizationpositiveregulationofalpha-betaTcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytokinesispositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationoflipaseactivitypositiveregulationofneuronapoptoticprocesspositiveregulationofneurondifferentiationpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofpodosomeassemblypositiveregulationofproteinserine/threoninekinaseactivitypositiveregulationofstressfiberassemblypositiveregulationofTcellmigrationpositiveregulationoftranslationpositiveregulationofvascularassociatedsmoothmusclecontractionregulationofactincytoskeletonorganizationregulationofcalciumiontransportregulationofcellmigrationregulationofcellshaperegulationofdendritedevelopmentregulationoffocaladhesionassemblyregulationofmicrotubulecytoskeletonorganizationregulationofmodificationofpostsynapticactincytoskeletonregulationofneuralprecursorcellproliferationregulationofosteoblastproliferationregulationofsystemicarterialbloodpressurebyendothelinregulationoftranscriptionbyRNApolymeraseIIresponsetoaminoacidresponsetoethanolresponsetoglucocorticoidresponsetoglucoseresponsetohypoxiaresponsetomechanicalstimulusresponsetoxenobioticstimulusRhoproteinsignaltransductionRoundaboutsignalingpathwayskeletalmusclesatellitecellmigrationskeletalmuscletissuedevelopmentstressfiberassemblystress-activatedproteinkinasesignalingcascadesubstantianigradevelopmentsubstrateadhesion-dependentcellspreadingtrabeculamorphogenesisWntsignalingpathwayplanarcellpolaritypathwaywoundhealingspreadingofcells
Insulin-like growth factor-binding protein 4
174
Insulin-like growth factor I
96
7.7
70
0.19
IBP4IGF1P22692P05019inflammatoryresponseMAPKcascadenegativeregulationofcanonicalWntsignalingpathwaypositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascaderegulationofcellgrowthregulationofglucosemetabolicprocessregulationofinsulin-likegrowthfactorreceptorsignalingpathwaysignaltransductiontypeBpancreaticcellproliferationactivationofproteinkinaseBactivitybonemineralizationinvolvedinbonematurationcellactivationcellpopulationproliferationcellularresponsetoamyloid-betaERK1andERK2cascadeglycolatemetabolicprocessinsulin-likegrowthfactorreceptorsignalingpathwaymusclehypertrophymuscleorgandevelopmentmyoblastdifferentiationmyoblastproliferationmyotubecelldevelopmentnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofinterleukin-1betaproductionnegativeregulationofneuroinflammatoryresponsenegativeregulationofoocytedevelopmentnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftumornecrosisfactorproductionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcardiacmusclehypertrophypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRasproteinsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftrophectodermalcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseBsignalingproteinstabilizationproteoglycanbiosyntheticprocessRasproteinsignaltransductionregulationofgeneexpressionregulationofmulticellularorganismgrowthregulationofproteinphosphorylationresponsetoheatskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationskeletalsystemdevelopmentwoundhealing
Glutamate receptor 2
330
Glutamate receptor 4
84
9.2
74
0.15
GRIA2GRIA4P19491P19493chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumionmodulationofchemicalsynaptictransmissionnegativeregulationofsmoothmusclecellapoptoticprocesspositiveregulationofsynaptictransmissionglutamatergicregulationofsynapsestructureoractivity
Glycoprotein hormones alpha chain
31
Follitropin subunit beta
102
6.4
53
0.29
GLHAFSHBP01215P01225follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationfemalegametegenerationfemalepregnancypositiveregulationofboneresorptionpositiveregulationofgeneexpressionprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationSertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Serine/threonine-protein kinase 32A
340
Serine/threonine-protein kinase 32A
340
7.0
45
0.32
ST32AST32AQ8WU08Q8WU08intracellularsignaltransductionpeptidyl-serinephosphorylation
Pygopus homolog 1
343
Pygopus homolog 1
371
7.4
68
0.2
PYGO1PYGO1Q9Y3Y4Q9Y3Y4canonicalWntsignalingpathwayhematopoieticprogenitorcelldifferentiationkidneydevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationtonucleusspermatidnucleusdifferentiation
Insulin-like growth factor I
96
Insulin-like growth factor-binding protein 1
176
7.7
71
0.18
IGF1IBP1P05019P08833activationofproteinkinaseBactivitybonemineralizationinvolvedinbonematurationcellactivationcellpopulationproliferationcellularresponsetoamyloid-betaERK1andERK2cascadeglycolatemetabolicprocessinsulin-likegrowthfactorreceptorsignalingpathwaymusclehypertrophymuscleorgandevelopmentmyoblastdifferentiationmyoblastproliferationmyotubecelldevelopmentnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofinterleukin-1betaproductionnegativeregulationofneuroinflammatoryresponsenegativeregulationofoocytedevelopmentnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftumornecrosisfactorproductionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcardiacmusclehypertrophypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRasproteinsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftrophectodermalcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseBsignalingproteinstabilizationproteoglycanbiosyntheticprocessRasproteinsignaltransductionregulationofgeneexpressionregulationofmulticellularorganismgrowthregulationofproteinphosphorylationresponsetoheatsignaltransductionskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationskeletalsystemdevelopmentwoundhealingaginginsulinreceptorsignalingpathwaynegativeregulationofcanonicalWntsignalingpathwaypositiveregulationofcellgrowthregulationofinsulin-likegrowthfactorreceptorsignalingpathwaytissueregeneration
Mothers against decapentaplegic homolog 2
463
Mothers against decapentaplegic homolog 2
436
9.3
73
0.15
SMAD2SMAD2Q15796Q15796activinreceptorsignalingpathwayadrenalglanddevelopmentanatomicalstructuremorphogenesisanterior/posteriorpatternspecificationBMPsignalingpathwaycelldifferentiationcellfatecommitmentcommon-partnerSMADproteinphosphorylationembryoniccranialskeletonmorphogenesisembryonicforegutmorphogenesisendodermformationgastrulationinuteroembryonicdevelopmentinsulinsecretionintracellularsignaltransductionlungdevelopmentmesodermformationnegativeregulationofcellpopulationproliferationnegativeregulationoftranscriptionDNA-templatednodalsignalingpathwayorgangrowthpancreasdevelopmentparaxialmesodermmorphogenesispericardiumdevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofgeneexpressionpositiveregulationofnodalsignalingpathwayinvolvedindeterminationoflateralmesodermleft/rightasymmetrypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpost-embryonicdevelopmentprimarymiRNAprocessingregulationofbindingregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoglucosesecondarypalatedevelopmentsignaltransductioninvolvedinregulationofgeneexpressionSMADproteincomplexassemblySMADproteinsignaltransductiontranscriptionDNA-templatedtransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentwoundhealingzygoticspecificationofdorsal/ventralaxis
PRSS3 protein
52
Pancreatic trypsin inhibitor
49
9.2
97
0.11
Q8N2U3BPT1Q8N2U3P00974proteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
C-type lectin domain family 2 member D
75
C-type lectin domain family 2 member D
75
9.2
61
0.18
CLC2DCLC2DQ9UHP7Q9UHP7cellsurfacereceptorsignalingpathway
NKG2-D type II integral membrane protein
115
NKG2-D type II integral membrane protein
112
7.7
74
0.18
NKG2DNKG2DO54709O54709adaptiveimmuneresponsecelldifferentiationcellularresponsetolipopolysaccharidedefenseresponsetoGram-positivebacteriumnaturalkillercellactivationnaturalkillercellmediatedcytotoxicitynegativeregulationofGTPaseactivitynegativeregulationofnaturalkillercellchemotaxisnitricoxidebiosyntheticprocesspositiveregulationofapoptoticprocesspositiveregulationofinterferon-gammaproductionpositiveregulationofmyeloiddendriticcellactivationpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationofnitricoxidebiosyntheticprocessstimulatoryC-typelectinreceptorsignalingpathway
Histone deacetylase 6
1120
Histone deacetylase 6
1113
8.5
69
0.17
HDAC6HDAC6Q9UBN7Q9UBN7aggresomeassemblyautophagyaxonaltransportofmitochondrioncellularresponsetohydrogenperoxidecellularresponsetomisfoldedproteincellularresponsetotopologicallyincorrectproteinciliumassemblyciliumdisassemblycollateralsproutingdendriticspinemorphogenesishistonedeacetylationHsp90deacetylationintracellularproteintransportlysosomelocalizationnegativeregulationofhydrogenperoxidemetabolicprocessnegativeregulationofmicrotubuledepolymerizationnegativeregulationofoxidoreductaseactivitynegativeregulationofprotein-containingcomplexassemblynegativeregulationofprotein-containingcomplexdisassemblynegativeregulationofproteolysisnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedparkin-mediatedstimulationofmitophagyinresponsetomitochondrialdepolarizationpeptidyl-lysinedeacetylationpolyubiquitinatedmisfoldedproteintransportpositiveregulationofepithelialcellmigrationpositiveregulationofhydrogenperoxide-mediatedprogrammedcelldeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsignalingreceptoractivityproteindeacetylationproteindestabilizationproteinpolyubiquitinationproteinqualitycontrolformisfoldedorincompletelysynthesizedproteinsprotein-containingcomplexdisassemblyregulationofandrogenreceptorsignalingpathwayregulationofautophagyregulationofautophagyofmitochondrionregulationofestablishmentofproteinlocalizationregulationoffatcelldifferentiationregulationofgeneexpressionepigeneticregulationofmacroautophagyregulationofmicrotubule-basedmovementregulationofproteinstabilityresponsetogrowthfactorresponsetomisfoldedproteintubulindeacetylationubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathway
F-box only protein 11
890
F-box only protein 11
856
7.3
63
0.22
FBX11FBX11Q86XK2Q86XK2proteinmodificationprocessproteinubiquitinationregulationofapoptoticprocesssensoryperceptionofsoundubiquitin-dependentproteincatabolicprocess
NAD-capped RNA hydrolase NUDT12
400
NAD-capped RNA hydrolase NUDT12
117
9.4
74
0.14
NUD12NUD12Q9BQG2Q9BQG2circadianregulationofgeneexpressionmethylguanosine-capdecappingmRNAcatabolicprocessNADbiosynthesisvianicotinamideribosidesalvagepathwayNADcatabolicprocessNAD-capdecappingNADHmetabolicprocessNADPcatabolicprocess
Retinoblastoma-like protein 1
846
AT-rich interactive domain-containing protein 4A
959
9.3
73
0.15
RBL1ARI4AP28749P29374cellcyclecelldifferentiationchromatinorganizationnegativeregulationofcellularsenescencenegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIIregulationofcelldivisionregulationoflipidkinaseactivityerythrocytedevelopmentestablishmentofSertolicellbarrierhistoneH3-K4trimethylationhistoneH3-K9trimethylationhistoneH4-K20trimethylationnegativeregulationofcellmigrationnegativeregulationofstemcellpopulationmaintenancenegativeregulationoftranscriptionDNA-templatednegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofstemcellpopulationmaintenancepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofgeneexpressionbygenomicimprintingregulationoftranscriptionbyRNApolymeraseIIspermatogenesistranscriptionbyRNApolymeraseII
PRSS3 protein
52
Amyloid-beta precursor protein
300
9.4
96
0.11
Q8N2U3A4Q8N2U3P05067proteolysisadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Amyloid-beta precursor protein
144
Amyloid-beta precursor protein
187
6.2
73
0.22
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
C-type lectin domain family 4 member D
66
C-type lectin domain family 4 member D
66
3.5
83
0.35
CLC4DCLC4DQ8WXI8Q8WXI8adaptiveimmuneresponseantifungalinnateimmuneresponsedefenseresponsetobacteriumFc-gammareceptorsignalingpathwayimmuneresponsepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofmyeloiddendriticcellactivationTcelldifferentiationinvolvedinimmuneresponse
High affinity nerve growth factor receptor
579
High affinity nerve growth factor receptor
501
4.0
63
0.4
NTRK1NTRK1P04629P04629agingaxonguidanceaxonogenesisinvolvedininnervationBcelldifferentiationbehavioralresponsetoformalininducedpaincellularresponsetonervegrowthfactorstimuluscellularresponsetonicotinecircadianrhythmdetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainlearningormemorymechanoreceptordifferentiationnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationnegativeregulationofneuronapoptoticprocessnervegrowthfactorsignalingpathwayneuronapoptoticprocessneurondevelopmentneuronprojectiondevelopmentneurotrophinTRKreceptorsignalingpathwayolfactorynervedevelopmentpeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofangiogenesispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofkinaseactivitypositiveregulationofneuronprojectiondevelopmentpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofprogrammedcelldeathpositiveregulationofproteinphosphorylationpositiveregulationofRasproteinsignaltransductionpositiveregulationofsynapseassemblypositiveregulationofsynaptictransmissionglutamatergicprogrammedcelldeathinvolvedincelldevelopmentproteinautophosphorylationproteinphosphorylationregulationofproteinkinaseBsignalingresponsetoaxoninjuryresponsetoelectricalstimulusresponsetohydrostaticpressureresponsetonutrientlevelsresponsetoradiationresponsetoxenobioticstimulusSertolicelldevelopmentsympatheticnervoussystemdevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathway
Nesprin-4
382
Nesprin-4
381
9.7
42
0.25
SYNE4SYNE4Q8N205Q8N205establishmentofepithelialcellapical/basalpolarity
DNA repair protein RAD52 homolog
208
DNA repair protein RAD52 homolog
29
8.1
60
0.21
RAD52RAD52P43351P43351cellularresponsetoDNAdamagestimuluscellularresponsetooxidativestressDNAdouble-strandbreakprocessinginvolvedinrepairviasingle-strandannealingDNArecombinaseassemblyDNArecombinationdouble-strandbreakrepairdouble-strandbreakrepairviahomologousrecombinationdouble-strandbreakrepairviasingle-strandannealingmitoticrecombinationregulationofnucleotide-excisionrepair
Defensin alpha 4
82
Defensin alpha 4
65
9.2
65
0.17
DEF4DEF4P12838P12838antibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideantimicrobialhumoralresponsecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingofcellsofanotherorganismmembranedisruptioninanotherorganismTcellchemotaxis
ATPase WRNIP1
23
ATPase WRNIP1
39
7.8
37
0.35
WRIP1WRIP1Q96S55Q96S55DNAsynthesisinvolvedinDNArepairDNA-templatedDNAreplicationinnateimmuneresponseregulationofDNArepairregulationofDNA-templatedDNAreplicationinitiation
DNA repair protein RAD52 homolog
25
DNA repair protein RAD52 homolog
29
9.5
64
0.16
RAD52RAD52P43351P43351cellularresponsetoDNAdamagestimuluscellularresponsetooxidativestressDNAdouble-strandbreakprocessinginvolvedinrepairviasingle-strandannealingDNArecombinaseassemblyDNArecombinationdouble-strandbreakrepairdouble-strandbreakrepairviahomologousrecombinationdouble-strandbreakrepairviasingle-strandannealingmitoticrecombinationregulationofnucleotide-excisionrepair
Neutrophil defensin 1
68
Neutrophil defensin 1
68
4.2
78
0.3
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismmodificationbyhostofsymbiontmembraneTcellchemotaxis
Beta-microseminoprotein
22
Beta-microseminoprotein
70
9.9
54
0.19
MSMBMSMBP08118P08118
Ubiquitin-like modifier-activating enzyme 5
250
Ubiquitin-like modifier-activating enzyme 5
95
8.6
nan
nan
UBA5UBA5Q9GZZ9Q9GZZ9erythrocytedifferentiationmegakaryocytedifferentiationneuromuscularprocessproteinK69-linkedufmylationproteinmodificationbysmallproteinconjugationproteinufmylationregulationofintracellularestrogenreceptorsignalingpathwayresponsetoendoplasmicreticulumstressreticulophagy
Natural killer cells antigen CD94
58
NKG2-A/NKG2-B type II integral membrane protein
116
6.0
50
0.33
KLRD1NKG2AQ13241P26715adaptiveimmuneresponsecellsurfacereceptorsignalingpathwaynaturalkillercellmediatedimmunitynegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofTcellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicityregulationofnaturalkillercellactivationstimulatoryC-typelectinreceptorsignalingpathwayCD8-positivegamma-deltaintraepithelialTcelldifferentiationinnateimmuneresponsenaturalkillercellinhibitorysignalingpathway
Natural killer cells antigen CD94
61
NKG2-A/NKG2-B type II integral membrane protein
116
7.8
59
0.22
KLRD1NKG2AQ13241P26715adaptiveimmuneresponsecellsurfacereceptorsignalingpathwaynaturalkillercellmediatedimmunitynegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofTcellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicityregulationofnaturalkillercellactivationstimulatoryC-typelectinreceptorsignalingpathwayCD8-positivegamma-deltaintraepithelialTcelldifferentiationinnateimmuneresponsenaturalkillercellinhibitorysignalingpathway
Neutrophil defensin 1
83
Neutrophil defensin 1
66
9.5
62
0.17
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismmodificationbyhostofsymbiontmembraneTcellchemotaxis
Defensin alpha 5
65
Defensin alpha 5
67
9.4
66
0.16
DEF5DEF5Q01523Q01523antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismpositiveregulationofinterleukin-8productionpositiveregulationofmembranepermeabilityproteinhomotetramerization
Endothelin-1
55
Endothelin-1
53
5.3
57
0.33
EDN1EDN1P05305P05305adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayarterysmoothmusclecontractionaxonextensionaxonogenesisinvolvedininnervationbodyfluidsecretionbranchinginvolvedinbloodvesselmorphogenesiscalciumiontransmembranetransportcalcium-mediatedsignalingcanonicalWntsignalingpathwaycardiacneuralcrestcellmigrationinvolvedinoutflowtractmorphogenesiscartilagedevelopmentcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularcalciumionhomeostasiscellularresponsetocalciumioncellularresponsetofattyacidcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetohumanchorionicgonadotropinstimuluscellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoluteinizinghormonestimuluscellularresponsetomineralocorticoidstimuluscellularresponsetoorganicsubstancecellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetotumornecrosisfactorcellularresponsetoxenobioticstimulusdorsal/ventralpatternformationembryonichearttubedevelopmentendothelinreceptorsignalingpathwayendothelinreceptorsignalingpathwayinvolvedinheartprocessepithelialfluidtransportERK1andERK2cascadeGprotein-coupledreceptorsignalingpathwayhistaminesecretionI-kappaBkinase/NF-kappaBsignalinginuteroembryonicdevelopmentinositolphosphate-mediatedsignalingleukocyteactivationmaternalprocessinvolvedinparturitionmeioticcellcycleprocessinvolvedinoocytematurationmembranedepolarizationmiddleearmorphogenesismitochondrionorganizationmulticellularorganismagingnegativeregulationofbloodcoagulationnegativeregulationofgeneexpressionnegativeregulationofhormonesecretionnegativeregulationofnitric-oxidesynthasebiosyntheticprocessnegativeregulationofproteinmetabolicprocessnegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneuralcrestcellfatecommitmentnitricoxidetransportnoradrenergicneurondifferentiationpeptidehormonesecretionpharyngealarcharterymorphogenesisphosphatidylinositol3-kinasesignalingphospholipaseD-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcardiacmusclehypertrophypositiveregulationofcationchannelactivitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellsizepositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellmigrationpositiveregulationofheartratepositiveregulationofhormonesecretionpositiveregulationofJUNkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofmitoticnucleardivisionpositiveregulationofneutrophilchemotaxispositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofodontogenesispositiveregulationofprostaglandinsecretionpositiveregulationofprostaglandin-endoperoxidesynthaseactivitypositiveregulationofrenalsodiumexcretionpositiveregulationofsarcomereorganizationpositiveregulationofsignalingreceptoractivitypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsmoothmusclecontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofurinevolumepositiveregulationofvascularassociatedsmoothmusclecellproliferationprostaglandinbiosyntheticprocessproteinkinaseAsignalingproteinkinaseCdeactivationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteinphosphorylationregulationofglucosetransmembranetransportregulationofpHregulationofsensoryperceptionofpainregulationofsystemicarterialbloodpressurebyendothelinregulationofvasoconstrictionrenalsodiumionabsorptionrespiratorygaseousexchangebyrespiratorysystemresponsetoactivityresponsetoaminoacidresponsetoamphetamineresponsetodexamethasoneresponsetoleptinresponsetolipopolysaccharideresponsetomusclestretchresponsetonicotineresponsetoozoneresponsetoprostaglandinFresponsetosaltresponsetotestosteronerhythmicexcitationsemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesensoryperceptionofpainsuperoxideaniongenerationsympatheticneuronaxonguidancethyroidglanddevelopmenttranscriptionbyRNApolymeraseIIvasoconstrictionveinsmoothmusclecontraction
Insulin
83
Insulin
31
7.8
66
0.19
A6XGL2A6XGL2A6XGL2A6XGL2glucosemetabolicprocess
Amyloid-beta precursor protein
291
Amyloid-beta precursor protein
316
7.5
60
0.22
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Amyloid-beta precursor protein
174
Amyloid-beta precursor protein
187
8.2
79
0.15
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
GTP-binding protein GEM
215
GTP-binding protein GEM
106
8.0
65
0.19
GEMGEMP55040P55040cellsurfacereceptorsignalingpathwaychromosomeorganizationimmuneresponsemetaphaseplatecongressionmitoticcellcyclenegativeregulationofhighvoltage-gatedcalciumchannelactivitysignaltransduction
G1/S-specific cyclin-D1
8
Cyclin-dependent kinase 4
135
9.8
46
0.22
CCND1CDK4P24385P11802celldivisioncellularresponsetoDNAdamagestimulusendoplasmicreticulumunfoldedproteinresponsefatcelldifferentiationG1/StransitionofmitoticcellcyclelactationLeydigcelldifferentiationliverregenerationmammaryglandalveolusdevelopmentmammaryglandepithelialcellproliferationmitoticcellcyclephasetransitionmitoticG1DNAdamagecheckpointsignalingnegativeregulationofepithelialcelldifferentiationnegativeregulationofneuronapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneurondifferentiationpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofmammaryglandepithelialcellproliferationpositiveregulationofproteinphosphorylationproteinphosphorylationre-entryintomitoticcellcycleregulationofcyclin-dependentproteinserine/threoninekinaseactivityresponsetocalciumionresponsetocorticosteroneresponsetoestradiolresponsetoestrogenresponsetoethanolresponsetoironionresponsetoleptinresponsetomagnesiumionresponsetoorganonitrogencompoundresponsetoUV-AresponsetovitaminEresponsetoX-rayresponsetoxenobioticstimulusWntsignalingpathwayadiposetissuedevelopmentcellularresponsetoinsulinstimuluscellularresponsetointerleukin-4cellularresponsetoionomycincellularresponsetolipopolysaccharidecellularresponsetophorbol13-acetate12-myristatepositiveregulationofcellpopulationproliferationpositiveregulationoffibroblastproliferationregulationofcellcycleregulationofgeneexpressionregulationofinsulinreceptorsignalingpathwayregulationoflipidbiosyntheticprocessregulationoflipidcatabolicprocessregulationofmulticellularorganismgrowthregulationoftranscriptioninitiationfromRNApolymeraseIIpromoterregulationoftypeBpancreaticcellproliferationsignaltransduction
Fibrinogen beta chain
110
Fibrinogen gamma chain
34
7.3
62
0.22
FIBBFIBGP02675P02679adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Histone-lysine N-methyltransferase 2C
1078
Histone-lysine N-methyltransferase 2C
1057
8.9
69
0.16
KMT2CKMT2CQ8NEZ4Q8NEZ4chromatinorganizationhistoneH3-K4methylationhistoneH3-K4monomethylationpositiveregulationoftranscriptionbyRNApolymeraseII
Neutrophil defensin 1
93
Neutrophil defensin 1
68
8.8
73
0.16
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismmodificationbyhostofsymbiontmembraneTcellchemotaxis
Interleukin-6 receptor subunit alpha
165
Interleukin-6 receptor subunit alpha
132
8.2
65
0.19
IL6RAIL6RAP08887P08887acute-phaseresponseciliaryneurotrophicfactor-mediatedsignalingpathwaycytokine-mediatedsignalingpathwaydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumendocrinepancreasdevelopmentextrinsicapoptoticsignalingpathwayhepaticimmuneresponseinterleukin-6-mediatedsignalingpathwaymonocytechemotaxisnegativeregulationofcollagenbiosyntheticprocessnegativeregulationofinterleukin-8productionneutrophilmediatedimmunitypositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcellpopulationproliferationpositiveregulationofchemokineproductionpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofinterleukin-6productionpositiveregulationofleukocytechemotaxispositiveregulationofMAPKcascadepositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofplateletaggregationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinresponsetocytokineT-helper17celllineagecommitmentvascularendothelialgrowthfactorproduction
Neuroblastoma suppressor of tumorigenicity 1
82
Neuroblastoma suppressor of tumorigenicity 1
63
8.1
77
0.16
NBL1NBL1P41271P41271animalorganmorphogenesisdeterminationofdorsalidentitynegativeregulationofBMPsignalingpathwaynegativeregulationofmonocytechemotaxisnervoussystemdevelopmentneuronprojectionmorphogenesispositiveregulationofneurondifferentiationsequesteringofBMPfromreceptorviaBMPbindingsequesteringofBMPinextracellularmatrix
Cryptochrome-2
432
Period circadian protein homolog 2
1213
4.3
60
0.39
CRY2PER2Q9R194O54943circadianregulationofgeneexpressioncircadianrhythmentrainmentofcircadianclockbyphotoperiodglucosehomeostasislipidstoragenegativeregulationofcircadianrhythmnegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofglucocorticoidsecretionnegativeregulationofphosphoproteinphosphataseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedproteinimportintonucleusregulationofcircadianrhythmregulationofsodium-dependentphosphatetransportresponsetoactivityresponsetoinsulinresponsetolightstimuluscircadianregulationoftranslationfattyacidmetabolicprocessgluconeogenesisglycogenbiosyntheticprocesshistoneH3deacetylationlactatebiosyntheticprocessnegativeregulationofDNA-templatedtranscriptionterminationnegativeregulationoffatcellproliferationnegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationofcold-inducedthermogenesisregulationofcellcycleregulationofglutamateuptakeinvolvedintransmissionofnerveimpulseregulationofinsulinsecretionregulationofneurogenesisregulationofvasoconstrictionresponsetoischemiawhitefatcelldifferentiation
NKG2-D type II integral membrane protein
96
NKG2-D type II integral membrane protein
96
6.5
74
0.21
NKG2DNKG2DP26718P26718adaptiveimmuneresponsecelldifferentiationcellularresponsetolipopolysaccharidedefenseresponsetoGram-positivebacteriumnaturalkillercellactivationnaturalkillercellmediatedcytotoxicitynegativeregulationofGTPaseactivitynegativeregulationofnaturalkillercellchemotaxisnitricoxidebiosyntheticprocesspositiveregulationofinterferon-gammaproductionpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnitricoxidebiosyntheticprocesssignaltransductionstimulatoryC-typelectinreceptorsignalingpathwayTcellcostimulation
Platelet-derived growth factor subunit A
179
Platelet-derived growth factor subunit A
123
9.9
61
0.17
PDGFAPDGFAP04085P04085actincytoskeletonorganizationangiogenesisanimalorganmorphogenesiscellactivationcellprojectionassemblycell-cellsignalingcellularresponsetotransforminggrowthfactorbetastimulusembryoniclungdevelopmenthairfollicledevelopmentinnereardevelopmentlungalveolusdevelopmentmalegonaddevelopmentnegativechemotaxisnegativeregulationofphosphatidylinositolbiosyntheticprocessnegativeregulationofplateletactivationplatelet-derivedgrowthfactorreceptorsignalingpathwayplatelet-derivedgrowthfactorreceptor-alphasignalingpathwaypositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmesenchymalcellproliferationpositiveregulationofmetanephricmesenchymalcellmigrationbyplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingregulationofactincytoskeletonorganizationregulationofbranchinginvolvedinsalivaryglandmorphogenesisbyepithelial-mesenchymalsignalingregulationofpeptidyl-tyrosinephosphorylationregulationofsmoothmusclecellmigrationresponsetoestradiolresponsetohypoxiaresponsetoinorganicsubstanceresponsetoretinoicacidresponsetowoundingresponsetoxenobioticstimulusskindevelopmentwoundhealing
Inhibitor of nuclear factor kappa-B kinase subunit beta
662
Inhibitor of nuclear factor kappa-B kinase subunit beta
662
8.2
52
0.24
IKKBIKKBO14920O14920antigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassITAP-dependentcellularresponsetotumornecrosisfactorcorticalactincytoskeletonorganizationFc-epsilonreceptorsignalingpathwayI-kappaBkinase/NF-kappaBsignalinginflammatoryresponseinnateimmuneresponseinterleukin-1-mediatedsignalingpathwaynegativeregulationofbicellulartightjunctionassemblynegativeregulationofmyosin-light-chain-phosphataseactivitypeptidyl-serinephosphorylationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedproteinlocalizationtoplasmamembraneproteinphosphorylationregulationofestablishmentofendothelialbarrierregulationofphosphorylationregulationoftumornecrosisfactor-mediatedsignalingpathwayresponsetovirusstimulatoryC-typelectinreceptorsignalingpathwaystress-activatedMAPKcascadeTcellreceptorsignalingpathwaytumornecrosisfactor-mediatedsignalingpathway
Neutrophil defensin 1
94
Neutrophil defensin 1
66
9.9
nan
nan
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismmodificationbyhostofsymbiontmembraneTcellchemotaxis
Defensin alpha 4
67
Defensin alpha 4
67
5.7
78
0.22
DEF4DEF4P12838P12838antibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideantimicrobialhumoralresponsecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingofcellsofanotherorganismmembranedisruptioninanotherorganismTcellchemotaxis
Neutrophil defensin 3
68
Neutrophil defensin 3
83
4.4
67
0.34
DEF3DEF3P59666P59666antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetovirusinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Cartilage oligomeric matrix protein
68
Cartilage oligomeric matrix protein
68
9.4
50
0.21
COMPCOMPQ9R0G6Q9R0G6apoptoticprocessarterymorphogenesisbloodcoagulationBMPsignalingpathwaybonegrowthbonemineralizationbonemorphogenesiscartilagedevelopmentcartilagehomeostasischondrocytedevelopmentchondrocyteproliferationcollagenfibrilorganizationendochondralbonegrowthgrowthplatecartilagedevelopmentlimbdevelopmentmulticellularorganismagingmulticellularorganismgrowthmusclecelldevelopmentmusculoskeletalmovementnegativeregulationofapoptoticprocessnegativeregulationofhemostasisneuromuscularprocessossificationplateletaggregationpositiveregulationofchondrocyteproliferationproteinhomooligomerizationproteinprocessingproteinsecretionregulationofbonemineralizationregulationofgeneexpressionresponsetounfoldedproteinskeletalsystemdevelopmentskindevelopmenttendondevelopmentvascularassociatedsmoothmusclecelldevelopmentvascularassociatedsmoothmusclecontraction
Anionic trypsin-2
64
Pancreatic trypsin inhibitor
49
8.1
96
0.13
TRY2BPT1P00763P00974collagencatabolicprocessdigestionproteolysisresponsetonutrientnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
C-C motif chemokine 5
33
C-C motif chemokine 5
57
6.1
66
0.25
CCL5CCL5P13501P13501activationofphospholipaseDactivitycalciumiontransportcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetoviruschemokine-mediatedsignalingpathwaychemotaxisdendriticcellchemotaxiseosinophilchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwayinflammatoryresponseleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofinnateimmuneresponsepositiveregulationofmacrophagechemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftranslationalinitiationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofviralgenomereplicationproteinkinaseBsignalingregulationofchronicinflammatoryresponseregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetotoxicsubstanceresponsetovirus
Caspase-3
264
Caspase-3
264
8.5
86
0.14
CASP3CASP3P42574P42574anteriorneuraltubeclosureapoptoticprocessapoptoticsignalingpathwayaxonalfasciculationBcellhomeostasiscellfatecommitmentcellularresponsetoDNAdamagestimuluscellularresponsetostaurosporineepithelialcellapoptoticprocesserythrocytedifferentiationexecutionphaseofapoptosisfibroblastapoptoticprocessglialcellapoptoticprocessheartdevelopmenthippocampusdevelopmentintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoosmoticstresskeratinocytedifferentiationlearningormemoryleukocyteapoptoticprocessluteolysisnegativeregulationofactivatedTcellproliferationnegativeregulationofapoptoticprocessnegativeregulationofBcellproliferationneuronapoptoticprocessneurondifferentiationneurotrophinTRKreceptorsignalingpathwayplateletformationpositiveregulationofamyloid-betaformationpositiveregulationofapoptoticDNAfragmentationpositiveregulationofapoptoticprocesspositiveregulationofneuronapoptoticprocessproteincatabolicprocessproteinprocessingproteolysisregulationofmacroautophagyregulationofproteinstabilityresponsetoaminoacidresponsetoantibioticresponsetocobaltionresponsetoestradiolresponsetoglucocorticoidresponsetoglucoseresponsetohydrogenperoxideresponsetohypoxiaresponsetolipopolysaccharideresponsetonicotineresponsetotumornecrosisfactorresponsetoUVresponsetoX-rayresponsetoxenobioticstimulussensoryperceptionofsoundstriatedmusclecelldifferentiationTcellhomeostasiswoundhealing
C-type lectin domain family 2 member D11
80
C-type lectin domain family 2 member D11
80
8.1
70
0.18
CL2DBCL2DBQ0H8B9Q0H8B9
Placenta growth factor
77
Placenta growth factor
130
9.2
61
0.18
PLGFPLGFP49763P49763animalorganregenerationcelldifferentiationcell-cellsignalingcellularresponsetohormonestimulusfemalepregnancyinductionofpositivechemotaxispositiveregulationofangiogenesispositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellproliferationpositiveregulationofmastcellchemotaxispositiveregulationofproteinphosphorylationresponsetohypoxiaresponsetoxenobioticstimulussignaltransductionsproutingangiogenesisvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathway
Cryptochrome-2
430
Period circadian protein homolog 2
1213
9.0
68
0.16
CRY2PER2Q9R194O54943circadianregulationofgeneexpressioncircadianrhythmentrainmentofcircadianclockbyphotoperiodglucosehomeostasislipidstoragenegativeregulationofcircadianrhythmnegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofglucocorticoidsecretionnegativeregulationofphosphoproteinphosphataseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedproteinimportintonucleusregulationofcircadianrhythmregulationofsodium-dependentphosphatetransportresponsetoactivityresponsetoinsulinresponsetolightstimuluscircadianregulationoftranslationfattyacidmetabolicprocessgluconeogenesisglycogenbiosyntheticprocesshistoneH3deacetylationlactatebiosyntheticprocessnegativeregulationofDNA-templatedtranscriptionterminationnegativeregulationoffatcellproliferationnegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationofcold-inducedthermogenesisregulationofcellcycleregulationofglutamateuptakeinvolvedintransmissionofnerveimpulseregulationofinsulinsecretionregulationofneurogenesisregulationofvasoconstrictionresponsetoischemiawhitefatcelldifferentiation
TNF receptor-associated factor 3
534
TRAF family member-associated NF-kappa-B activator
177
4.9
nan
nan
TRAF3TANKQ13114Q92844apoptoticprocessdefenseresponsetovirusnegativeregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofJNKcascadeproteinK63-linkedubiquitinationregulationofapoptoticprocessregulationofcytokineproductionregulationofdefenseresponsetovirusregulationofI-kappaBkinase/NF-kappaBsignalingregulationofinterferon-betaproductionregulationofproteolysissignaltransductionTollsignalingpathwaytoll-likereceptorsignalingpathwayTRIF-dependenttoll-likereceptorsignalingpathwaytumornecrosisfactor-mediatedsignalingpathwaytypeIinterferonsignalingpathwaycellularresponsetoDNAdamagestimuluscellularresponsetointerleukin-1cellularresponsetoionizingradiationcellularresponsetotumornecrosisfactorI-kappaBkinase/NF-kappaBsignalingnegativeregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofproteindeubiquitinationpositiveregulationofubiquitin-specificproteaseactivity
Aldo-keto reductase family 1 member C21
5
Aldo-keto reductase family 1 member C21
7
8.9
73
0.15
AK1CLAK1CLQ91WR5Q91WR5daunorubicinmetabolicprocessdoxorubicinmetabolicprocessprogesteronemetabolicprocessprostaglandinmetabolicprocesssteroidbiosyntheticprocesssteroidmetabolicprocess
Platelet factor 4
25
Platelet factor 4
67
9.9
72
0.14
PLF4PLF4P02777P02777adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaycytokine-mediatedsignalingpathwayinflammatoryresponseleukocytechemotaxisnegativeregulationofangiogenesisnegativeregulationofmegakaryocytedifferentiationneutrophilchemotaxisplateletactivationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellpopulationproliferation
Protein MEMO1
7
Protein MEMO1
7
7.3
58
0.24
MEMO1MEMO1Q9Y316Q9Y316regulationofmicrotubule-basedprocess
Glycoprotein hormones alpha chain
31
Follitropin subunit beta
50
6.8
54
0.27
GLHAFSHBP01215P01225follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationfemalegametegenerationfemalepregnancypositiveregulationofboneresorptionpositiveregulationofgeneexpressionprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationSertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Hepatocyte growth factor
129
Hepatocyte growth factor
289
9.7
73
0.14
HGFHGFQ08048Q08048animalorganregenerationcellchemotaxiscellmorphogenesiscellularresponsetohepatocytegrowthfactorstimulusepithelialcellproliferationhepatocytegrowthfactorreceptorsignalingpathwayliverdevelopmentmyoblastproliferationnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-6productionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofreleaseofcytochromecfrommitochondriapositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofinterleukin-10productionpositiveregulationofMAPKcascadepositiveregulationofmyelinationpositiveregulationofneuronprojectionregenerationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationproteolysisregulationofbranchinginvolvedinsalivaryglandmorphogenesisbymesenchymal-epithelialsignalingregulationofp38MAPKcascaderegulationoftau-proteinkinaseactivityskeletalmusclecellproliferation
Proprotein convertase subtilisin/kexin type 9
378
Low-density lipoprotein receptor
318
8.2
75
0.16
PCSK9LDLRQ8NBP7Q59FQ1apoptoticprocesscellularresponsetoinsulinstimuluscellularresponsetostarvationcholesterolhomeostasischolesterolmetabolicprocesskidneydevelopmentlipoproteinmetabolicprocessliverdevelopmentlow-densitylipoproteinparticlereceptorcatabolicprocesslysosomaltransportnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationoflow-densitylipoproteinparticlereceptorbindingnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofreceptorinternalizationnegativeregulationofreceptorrecyclingnegativeregulationofreceptor-mediatedendocytosisinvolvedincholesteroltransportnegativeregulationofsodiumiontransmembranetransporteractivityneurogenesisneurondifferentiationphospholipidmetabolicprocesspositiveregulationoflow-densitylipoproteinparticlereceptorcatabolicprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofreceptorinternalizationproteinautoprocessingregulationofneuronapoptoticprocessregulationofsignalingreceptoractivitytriglyceridemetabolicprocessamyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessarterymorphogenesiscellularresponsetofattyacidcellularresponsetolow-densitylipoproteinparticlestimuluscholesterolimportcholesteroltransportendocytosishigh-densitylipoproteinparticleclearanceintestinalcholesterolabsorptionlipidmetabolicprocesslipoproteincatabolicprocesslong-termmemorylow-densitylipoproteinparticleclearancenegativeregulationofamyloidfibrilformationnegativeregulationofastrocyteactivationnegativeregulationofgeneexpressionnegativeregulationofmicroglialcellactivationnegativeregulationofproteinmetabolicprocessphagocytosisphospholipidtransportplasmalipoproteinparticleclearancepositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationoflysosomalproteincatabolicprocesspositiveregulationoftriglyceridebiosyntheticprocessreceptor-mediatedendocytosisreceptor-mediatedendocytosisinvolvedincholesteroltransportregulationofcholesterolmetabolicprocessregulationofphosphatidylcholinecatabolicprocessregulationofproteinmetabolicprocessresponsetocaloricrestriction
Bone morphogenetic protein 10
323
Bone morphogenetic protein 10
388
9.9
75
0.13
BMP10BMP10O95393O95393activinreceptorsignalingpathwayadultheartdevelopmentatrialcardiacmuscletissuemorphogenesisBMPsignalingpathwaycardiacmusclecellproliferationcelladhesionhearttrabeculaformationkidneydevelopmentnegativeregulationofcardiacmusclehypertrophynegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofendothelialcellmigrationpathway-restrictedSMADproteinphosphorylationpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcardiacmusclehypertrophypositiveregulationofcartilagedevelopmentpositiveregulationofcellproliferationinvolvedinheartmorphogenesispositiveregulationofgeneexpressionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofsarcomereorganizationpositiveregulationoftranscriptionDNA-templatedregulationofcardiacmusclecontractionregulationofcardiacmusclehypertrophyinresponsetostresssarcomereorganizationSMADproteinsignaltransductionventricularcardiacmusclecelldevelopmentventricularcardiacmuscletissuemorphogenesis
Transforming growth factor beta-2 proprotein
350
Transforming growth factor beta-2 proprotein
379
8.1
60
0.21
TGFB2TGFB2P61812P61812activationofproteinkinaseactivityascendingaortamorphogenesisatrialseptummorphogenesisatrialseptumprimummorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwaycardiacepithelialtomesenchymaltransitioncardiacmusclecellproliferationcardiacrightventriclemorphogenesiscardioblastdifferentiationcelldeathcellmigrationcellmorphogenesiscell-celljunctionorganizationcollagenfibrilorganizationcranialskeletalsystemdevelopmentdopaminebiosyntheticprocessembryodevelopmentendinginbirthoregghatchingembryonicdigestivetractdevelopmentembryoniclimbmorphogenesisendocardialcushionfusionendocardialcushionmorphogenesisepithelialtomesenchymaltransitionextrinsicapoptoticsignalingpathwayeyedevelopmentgenerationofneuronsglialcellmigrationhairfollicledevelopmenthairfolliclemorphogenesisheartdevelopmentheartmorphogenesisheartvalvemorphogenesishemopoiesisinnereardevelopmentkidneydevelopmentmalegonaddevelopmentmembranousseptummorphogenesisnegativeregulationofalkalinephosphataseactivitynegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofepithelialcellproliferationnegativeregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationnegativeregulationofgeneexpressionnegativeregulationofmacrophagecytokineproductionnegativeregulationofRasproteinsignaltransductionneuralretinadevelopmentneuraltubeclosureneurondevelopmentneutrophilchemotaxisodontogenesisoutflowtractseptummorphogenesispathway-restrictedSMADproteinphosphorylationpharyngealarcharterymorphogenesispositiveregulationofcardioblastdifferentiationpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcellcyclepositiveregulationofcelldivisionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationpositiveregulationofheartcontractionpositiveregulationofimmuneresponsepositiveregulationofintegrinbiosyntheticprocesspositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationofNotchsignalingpathwaypositiveregulationofossificationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofstress-activatedMAPKcascadepositiveregulationoftimingofcatagenproteinphosphorylationpulmonaryvalvemorphogenesisregulationofapoptoticprocessinvolvedinoutflowtractmorphogenesisregulationofcellpopulationproliferationregulationoftimingofcatagenregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetoprogesteroneresponsetowoundingresponsetoxenobioticstimulussalivaryglandmorphogenesissecondarypalatedevelopmentskeletalsystemdevelopmentSMADproteinsignaltransductionsomaticstemcelldivisionsubstantiapropriaofcorneadevelopmenttransforminggrowthfactorbetareceptorsignalingpathwayuterinewallbreakdownuterusdevelopmentventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesiswoundhealing
F-box only protein 11
872
F-box only protein 11
899
3.9
53
0.49
FBX11FBX11Q86XK2Q86XK2proteinmodificationprocessproteinubiquitinationregulationofapoptoticprocesssensoryperceptionofsoundubiquitin-dependentproteincatabolicprocess
Fibrinogen gamma chain
34
Fibrinogen gamma chain
34
3.3
43
0.7
FIBGFIBGP02679P02679bloodcoagulationfibrinclotformationcell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetointerleukin-6fibrinolysisnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofplateletaggregationplasminogenactivationplateletaggregationplateletmaturationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationproteinsecretionprotein-containingcomplexassemblyresponsetocalciumion
Amyloid-beta precursor protein
291
Amyloid-beta precursor protein
337
7.1
55
0.26
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
F-box/LRR-repeat protein 2
33
S-phase kinase-associated protein 1
160
6.3
nan
nan
FBXL2SKP1Q9UKC9P63208modulationbyhostofviralRNAgenomereplicationproteinmodificationprocessproteinmonoubiquitinationproteinubiquitinationproteolysisregulationofautophagyregulationofphosphatidylinositol3-kinasesignalingSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocesshistoneH2AmonoubiquitinationmaintenanceofproteinlocationinnucleuspositiveregulationofubiquitinproteinligaseactivityproteinK48-linkedubiquitinationproteinpolyubiquitination
Growth/differentiation factor 8
374
Growth/differentiation factor 8
339
8.9
74
0.15
GDF8GDF8O14793O14793cellularresponsetodexamethasonestimulusmusclecellcellularhomeostasismuscleorgandevelopmentmyoblastmigrationinvolvedinskeletalmuscleregenerationnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofkinaseactivitynegativeregulationofmusclehypertrophynegativeregulationofmyoblastdifferentiationnegativeregulationofmyoblastproliferationnegativeregulationofproteinkinaseBsignalingnegativeregulationofsatellitecelldifferentiationnegativeregulationofskeletalmusclesatellitecellproliferationnegativeregulationofskeletalmuscletissuegrowthovulationcycleprocesspositiveregulationoflamellipodiumassemblypositiveregulationofmacrophagechemotaxispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionDNA-templatedresponsetoelectricalstimulusresponsetoestrogenresponsetoethanolresponsetogravityresponsetoheatresponsetomuscleactivityresponsetotestosteroneskeletalmuscleatrophySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Chymotrypsinogen A
191
Serine protease inhibitor Kazal-type 1
39
9.8
100
0.1
CTRAISK1P00766P00995digestionproteolysiscellularresponsetopeptidehormonestimulusnegativeregulationofcalciumionimportnegativeregulationofnitricoxidemediatedsignaltransductionnegativeregulationofpeptidyl-tyrosinephosphorylationnegativeregulationofserine-typeendopeptidaseactivitynitricoxidemediatedsignaltransductionpeptidyl-tyrosinephosphorylationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofepithelialcellproliferationpositiveregulationofpancreaticjuicesecretionpositiveregulationofpeptidehormonesecretionregulationofacrosomereactionregulationofstore-operatedcalciumentryresponsetoethanolresponsetonutrientlevelsspermcapacitation
Proprotein convertase subtilisin/kexin type 9
375
Low-density lipoprotein receptor
318
8.8
61
0.19
PCSK9LDLRQ8NBP7Q59FQ1apoptoticprocesscellularresponsetoinsulinstimuluscellularresponsetostarvationcholesterolhomeostasischolesterolmetabolicprocesskidneydevelopmentlipoproteinmetabolicprocessliverdevelopmentlow-densitylipoproteinparticlereceptorcatabolicprocesslysosomaltransportnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationoflow-densitylipoproteinparticlereceptorbindingnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofreceptorinternalizationnegativeregulationofreceptorrecyclingnegativeregulationofreceptor-mediatedendocytosisinvolvedincholesteroltransportnegativeregulationofsodiumiontransmembranetransporteractivityneurogenesisneurondifferentiationphospholipidmetabolicprocesspositiveregulationoflow-densitylipoproteinparticlereceptorcatabolicprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofreceptorinternalizationproteinautoprocessingregulationofneuronapoptoticprocessregulationofsignalingreceptoractivitytriglyceridemetabolicprocessamyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessarterymorphogenesiscellularresponsetofattyacidcellularresponsetolow-densitylipoproteinparticlestimuluscholesterolimportcholesteroltransportendocytosishigh-densitylipoproteinparticleclearanceintestinalcholesterolabsorptionlipidmetabolicprocesslipoproteincatabolicprocesslong-termmemorylow-densitylipoproteinparticleclearancenegativeregulationofamyloidfibrilformationnegativeregulationofastrocyteactivationnegativeregulationofgeneexpressionnegativeregulationofmicroglialcellactivationnegativeregulationofproteinmetabolicprocessphagocytosisphospholipidtransportplasmalipoproteinparticleclearancepositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationoflysosomalproteincatabolicprocesspositiveregulationoftriglyceridebiosyntheticprocessreceptor-mediatedendocytosisreceptor-mediatedendocytosisinvolvedincholesteroltransportregulationofcholesterolmetabolicprocessregulationofphosphatidylcholinecatabolicprocessregulationofproteinmetabolicprocessresponsetocaloricrestriction
Amyloid beta precursor like protein 2
310
Amyloid beta precursor like protein 2
356
7.5
53
0.25
APLP2APLP2Q06481Q06481axonogenesiscentralnervoussystemdevelopmentGprotein-coupledreceptorsignalingpathwayregulationofcellularproteinmetabolicprocess
Membrane primary amine oxidase
748
Membrane primary amine oxidase
41
9.8
63
0.16
AOC3AOC3Q16853Q16853aminemetabolicprocesscelladhesioninflammatoryresponsenegativeregulationofprimaryamineoxidaseactivityresponsetoantibiotic
Microtubule-associated protein RP/EB family member 1
228
Microtubule-associated protein RP/EB family member 3
237
8.6
55
0.21
MARE1MARE3Q15691Q9UPY8attachmentofmitoticspindlemicrotubulestokinetochorecelldivisioncellmigrationestablishmentofmitoticspindleorientationmicrotubulebundleformationmicrotubulepolymerizationnegativeregulationofmicrotubulepolymerizationnon-motileciliumassemblypositiveregulationofmicrotubuleplus-endbindingpositiveregulationofmicrotubulepolymerizationproteinlocalizationproteinlocalizationtoastralmicrotubuleproteinlocalizationtocentrosomeproteinlocalizationtomicrotubuleproteinlocalizationtomicrotubuleplus-endregulationofmicrotubulepolymerizationordepolymerizationspindleassemblypositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofproteinkinaseactivitypositiveregulationoftranscriptionDNA-templatedregulationofmicrotubulepolymerization
Fibrinogen beta chain
106
Fibrinogen alpha chain
47
7.4
71
0.19
FIBBFIBAP02675P02671adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumionbloodcoagulationcommonpathwaynegativeregulationofbloodcoagulationcommonpathway
S-phase kinase-associated protein 1
160
F-box only protein 4
80
9.1
nan
nan
SKP1FBX4P63208Q9UKT5histoneH2AmonoubiquitinationmaintenanceofproteinlocationinnucleuspositiveregulationofubiquitinproteinligaseactivityproteinK48-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocessagingcellularhomeostasiscellularresponsetoionizingradiationcommonmyeloidprogenitorcellproliferationnegativeregulationoffibroblastproliferationnegativeregulationofproteinlocalizationtonucleuspositiveregulationofproteinpolyubiquitinationpositiveregulationofproteinubiquitinationpositiveregulationoftelomeremaintenanceviatelomerasepost-transcriptionalregulationofgeneexpressionproteindestabilizationregulationofDNAdamagecheckpointregulationofproteinstabilitytelomeremaintenanceubiquitin-dependentproteincatabolicprocess
Protein FAM3C
221
Protein FAM3C
58
9.5
62
0.17
FAM3CFAM3CQ91VU0Q91VU0negativeregulationofgluconeogenesis
Bone marrow stromal antigen 2
53
Bone marrow stromal antigen 2
53
8.0
75
0.17
BST2BST2Q10589Q10589BcellactivationdefenseresponsetovirusinnateimmuneresponsenegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofintracellulartransportofviralmaterialnegativeregulationofplasmacytoiddendriticcellcytokineproductionnegativeregulationofviralgenomereplicationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofleukocyteproliferationregulationofactincytoskeletonorganizationresponsetointerferon-alpharesponsetointerferon-betaresponsetointerferon-gammaresponsetovirus
Receptor-interacting serine/threonine-protein kinase 2
7
Receptor-interacting serine/threonine-protein kinase 2
7
5.0
50
0.4
RIPK2RIPK2O43353O43353activationofcysteine-typeendopeptidaseactivityadaptiveimmuneresponseapoptoticprocessCD4-positivealpha-betaTcellproliferationcellularresponsetolipoteichoicacidcellularresponsetomuramyldipeptidecellularresponsetopeptidoglycancytokine-mediatedsignalingpathwaydefenseresponsetoGram-positivebacteriumERK1andERK2cascadeI-kappaBkinase/NF-kappaBsignalingimmatureTcellproliferationinthymusinflammatoryresponseinnateimmuneresponseJNKcascadelipopolysaccharide-mediatedsignalingpathwaynucleotide-bindingoligomerizationdomaincontaining1signalingpathwaynucleotide-bindingoligomerizationdomaincontaining2signalingpathwaypositiveregulationofapoptoticprocesspositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcelldeathpositiveregulationofchemokineproductionpositiveregulationofcytokine-mediatedsignalingpathwaypositiveregulationofERK1andERK2cascadepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofimmatureTcellproliferationinthymuspositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationofmacrophagecytokineproductionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinubiquitinationpositiveregulationofT-helper1celldifferentiationpositiveregulationofT-helper1typeimmuneresponsepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationofxenophagyresponsetoexogenousdsRNAresponsetointerleukin-1responsetointerleukin-12responsetointerleukin-18signaltransductionTcellreceptorsignalingpathwaytoll-likereceptor2signalingpathwaytoll-likereceptor4signalingpathwayxenophagy
Platelet factor 4
83
Platelet factor 4
43
8.9
78
0.14
PLF4PLF4P02776P02776adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaycytokine-mediatedsignalingpathwaydefenseresponsetoprotozoaninflammatoryresponsekillingbyhostofsymbiontcellskillingofcellsofanotherorganismleukocytechemotaxisnegativeregulationofangiogenesisnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofmegakaryocytedifferentiationnegativeregulationofMHCclassIIbiosyntheticprocessneutrophilchemotaxisplateletactivationpositiveregulationofgeneexpressionpositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofmacrophagedifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionregulationofcellpopulationproliferation
Biglycan
64
Biglycan
188
9.9
67
0.15
PGS1PGS1P21809P21809articularcartilagedevelopmentbonedevelopmentpeptidecross-linkingviachondroitin4-sulfateglycosaminoglycan
Platelet factor 4 variant
46
Platelet factor 4 variant
86
9.3
69
0.16
PF4VPF4VP10720P10720antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwayinflammatoryresponseneutrophilchemotaxisplateletactivation
Dopamine beta-hydroxylase
154
Dopamine beta-hydroxylase
596
8.1
nan
nan
DOPODOPOP09172P09172behavioralresponsetoethanolbloodvesselremodelingchemicalsynaptictransmissiondopaminecatabolicprocessfearresponseglucosehomeostasishomoiothermyleukocytemediatedimmunityleukocytemigrationlocomotorybehaviormaternalbehaviormemorynorepinephrinebiosyntheticprocessoctopaminebiosyntheticprocesspositiveregulationofcold-inducedthermogenesispositiveregulationofvasoconstrictionregulationofextrinsicapoptoticsignalingpathwayregulationofvascularassociatedsmoothmusclecellproliferationregulationofvascularendothelialcellproliferationresponsetoamphetamineresponsetopainvasoconstrictionvisuallearning
Glutamate receptor 2
330
Glutamate receptor 3
334
8.8
72
0.16
GRIA2GRIA3P19491P19492chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumion
C-C motif chemokine 18
30
C-C motif chemokine 18
30
9.0
72
0.15
CCL18CCL18P55774P55774antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellcommunicationcell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitysignaltransduction
Glutamate receptor 2
330
Glutamate receptor 3
85
8.8
71
0.16
GRIA2GRIA3P19491P19492chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumion
F-box/WD repeat-containing protein 11
145
S-phase kinase-associated protein 1
160
3.5
62
0.47
FBW1BSKP1Q9UKB1P63208brainmorphogenesisestablishmentofmitoticspindleorientationgermcelldevelopmentmicrotubuleorganizingcenterorganizationnegativeregulationoftranscriptionDNA-templatednuclearmigrationpositiveregulationofcircadianrhythmpositiveregulationofproteolysispositiveregulationoftranscriptionDNA-templatedproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindephosphorylationproteindestabilizationproteinpolyubiquitinationproteinubiquitinationretrogradeaxonaltransportrhythmicprocessSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocessvesicletransportalongmicrotubuleWntsignalingpathwayhistoneH2AmonoubiquitinationmaintenanceofproteinlocationinnucleuspositiveregulationofubiquitinproteinligaseactivityproteinK48-linkedubiquitination
Heat shock factor 2-binding protein
128
Heat shock factor 2-binding protein
128
8.3
84
0.14
HSF2BHSF2BO75031O75031double-strandbreakrepairinvolvedinmeioticrecombinationfemalemeiosisImalemeiosisIspermatogenesistranscriptionbyRNApolymeraseII
Glutamate receptor 2
78
Glutamate receptor 2
78
8.8
79
0.14
GRIA2GRIA2P19491P19491chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumion
Rootletin
1152
Rootletin
1152
5.1
nan
nan
CROCCCROCCQ5TZA2Q5TZA2cellularhomeostasiscentriole-centriolecohesioncentrosomecycleciliarybasalbodyorganizationepithelialstructuremaintenanceestablishmentoflocalizationincellestablishmentoforganellelocalizationphotoreceptorcellmaintenancepositiveregulationofciliumassemblypositiveregulationofproteinlocalizationtociliumproteinlocalizationproteinlocalizationtoorganelle
Corticotropin-releasing factor receptor 1
393
Corticotropin-releasing factor receptor 1
262
8.3
68
0.18
CRFR1CRFR1P34998P34998activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwayadrenalglanddevelopmentbehavioralresponsetoethanolcellsurfacereceptorsignalingpathwaycellularresponsetocorticotropin-releasinghormonestimuluscorticotropinsecretionfearresponsefemalepregnancygeneraladaptationsyndromebehavioralprocessimmuneresponsenegativeregulationofvoltage-gatedcalciumchannelactivityparturitionregulationofadenylatecyclaseactivityinvolvedinGprotein-coupledreceptorsignalingpathwayregulationofcorticosteronesecretion
Caspase-4
105
Caspase-4
331
7.0
56
0.26
CASP4CASP4P70343P70343actinfilamentorganizationdefenseresponsetobacteriumdefenseresponsetoGram-positivebacteriumectopicgermcellprogrammedcelldeathinflammatoryresponseinnateimmuneresponsepositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-18-mediatedsignalingpathwaypositiveregulationofmacrophagecytokineproductionproteinautoprocessingpyroptosisregulationofapoptoticprocessregulationofinflammatoryresponse
Translation initiation factor eIF-2B subunit alpha
218
Translation initiation factor eIF-2B subunit alpha
218
5.1
77
0.25
EI2BAEI2BAQ14232Q14232oligodendrocytedevelopmentregulationofcatalyticactivityresponsetoglucoseresponsetoheatresponsetopeptidehormoneTcellreceptorsignalingpathwaytranslationalinitiation
E3 ubiquitin-protein ligase RNF31
551
E3 ubiquitin-protein ligase RNF31
551
8.3
81
0.15
RNF31RNF31Q96EP0Q96EP0CD40signalingpathwaydefenseresponsetobacteriumnegativeregulationofnecroptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteintargetingtomitochondrionpositiveregulationofxenophagyproteinlinearpolyubiquitinationproteinpolyubiquitinationTcellreceptorsignalingpathway
CASP8-associated protein 2
83
CASP8-associated protein 2
83
3.4
45
0.65
C8AP2C8AP2Q9UKL3Q9UKL3activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticsignalingpathwaycellcyclecellularresponsetomechanicalstimulusextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsFassignalingpathwaysignaltransduction
E3 ubiquitin-protein ligase RNF169
626
E3 ubiquitin-protein ligase RNF169
626
3.7
59
0.46
RN169RN169Q8NCN4Q8NCN4cellularresponsetoDNAdamagestimulusdouble-strandbreakrepairnegativeregulationofdouble-strandbreakrepair
Protein AF-9
5
Protein AF-9
5
3.7
76
0.35
AF9AF9P42568P42568anterior/posteriorpatternspecificationchromatinremodelinggeneexpressionhematopoieticstemcelldifferentiationhistoneacetylationnegativeregulationofcanonicalWntsignalingpathwaypositiveregulationoftranscriptionDNA-templatedpositiveregulationofWntsignalingpathwayplanarcellpolaritypathwayregulationofchromatinorganizationregulationofstemcelldivisionregulationoftranscriptionbyRNApolymeraseIIsegmentspecification
Natural killer cells antigen CD94
72
NKG2-A/NKG2-B type II integral membrane protein
116
8.7
66
0.18
KLRD1NKG2AQ13241P26715adaptiveimmuneresponsecellsurfacereceptorsignalingpathwaynaturalkillercellmediatedimmunitynegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofTcellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicityregulationofnaturalkillercellactivationstimulatoryC-typelectinreceptorsignalingpathwayCD8-positivegamma-deltaintraepithelialTcelldifferentiationinnateimmuneresponsenaturalkillercellinhibitorysignalingpathway
C-type lectin domain family 4 member D
83
C-type lectin domain family 4 member D
83
6.9
82
0.18
CLC4DCLC4DQ8WXI8Q8WXI8adaptiveimmuneresponseantifungalinnateimmuneresponsedefenseresponsetobacteriumFc-gammareceptorsignalingpathwayimmuneresponsepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofmyeloiddendriticcellactivationTcelldifferentiationinvolvedinimmuneresponse
Glutamate receptor 3
334
Glutamate receptor 3
334
8.4
73
0.16
GRIA3GRIA3P19492P19492regulationofreceptorrecyclingresponsetofungicideresponsetolithiumion
Proprotein convertase subtilisin/kexin type 9
375
Low-density lipoprotein receptor
318
8.7
68
0.17
PCSK9LDLRQ8NBP7P01130apoptoticprocesscellularresponsetoinsulinstimuluscellularresponsetostarvationcholesterolhomeostasischolesterolmetabolicprocesskidneydevelopmentlipoproteinmetabolicprocessliverdevelopmentlow-densitylipoproteinparticlereceptorcatabolicprocesslysosomaltransportnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationoflow-densitylipoproteinparticlereceptorbindingnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofreceptorinternalizationnegativeregulationofreceptorrecyclingnegativeregulationofreceptor-mediatedendocytosisinvolvedincholesteroltransportnegativeregulationofsodiumiontransmembranetransporteractivityneurogenesisneurondifferentiationphospholipidmetabolicprocesspositiveregulationoflow-densitylipoproteinparticlereceptorcatabolicprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofreceptorinternalizationproteinautoprocessingregulationofneuronapoptoticprocessregulationofsignalingreceptoractivitytriglyceridemetabolicprocessamyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessarterymorphogenesiscellularresponsetofattyacidcellularresponsetolow-densitylipoproteinparticlestimuluscholesterolimportcholesteroltransportendocytosishigh-densitylipoproteinparticleclearanceintestinalcholesterolabsorptionlipidmetabolicprocesslipoproteincatabolicprocesslong-termmemorylow-densitylipoproteinparticleclearancenegativeregulationofamyloidfibrilformationnegativeregulationofastrocyteactivationnegativeregulationofgeneexpressionnegativeregulationofmicroglialcellactivationnegativeregulationofproteinmetabolicprocessphagocytosisphospholipidtransportplasmalipoproteinparticleclearancepositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationoflysosomalproteincatabolicprocesspositiveregulationoftriglyceridebiosyntheticprocessreceptor-mediatedendocytosisreceptor-mediatedendocytosisinvolvedincholesteroltransportregulationofcholesterolmetabolicprocessregulationofphosphatidylcholinecatabolicprocessregulationofproteinmetabolicprocessresponsetocaloricrestriction
Trypsin-3
121
Tissue factor pathway inhibitor
63
8.4
96
0.12
TRY3TFPI1P35030P10646antimicrobialhumoralresponsedigestionendothelialcellmigrationproteolysiszymogenactivationbloodcoagulationcellularresponsetosteroidhormonestimulusnegativeregulationofbloodcoagulation
C-type lectin domain family 2 member D11
80
C-type lectin domain family 2 member D11
91
9.6
79
0.13
CL2DBCL2DBQ0H8B9Q0H8B9
Vascular endothelial growth factor A
77
Vascular endothelial growth factor A
130
9.6
70
0.15
VEGFAVEGFAQ96NW5Q96NW5activationofproteinkinaseactivityangiogenesisarterymorphogenesisbasophilchemotaxisbranchinginvolvedinbloodvesselmorphogenesiscamera-typeeyemorphogenesiscardiacmusclecelldevelopmentcardiacvascularsmoothmusclecelldevelopmentcellmaturationcellmigrationinvolvedinsproutingangiogenesiscellularresponsetohypoxiacellularresponsetovascularendothelialgrowthfactorstimuluscellularstressresponsetoacidchemicalcommissuralneuronaxonguidancecoronaryarterymorphogenesiscoronaryveinmorphogenesisdopaminergicneurondifferentiationendothelialcellchemotaxisepithelialcelldifferentiationeyephotoreceptorcelldevelopmentheartmorphogenesisinuteroembryonicdevelopmentinductionofpositivechemotaxiskidneydevelopmentlactationlungdevelopmentlymphvesselmorphogenesismacrophagedifferentiationmammaryglandalveolusdevelopmentmesodermdevelopmentmonocytedifferentiationmotorneuronmigrationnegativeregulationofadherensjunctionorganizationnegativeregulationofapoptoticprocessnegativeregulationofblood-brainbarrierpermeabilitynegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofestablishmentofendothelialbarriernegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentoutflowtractmorphogenesisovarianfollicledevelopmentpositivechemotaxispositiveregulationofangiogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelladhesionpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellmigrationbyvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofcellproliferationbyVEGF-activatedplateletderivedgrowthfactorreceptorsignalingpathwaypositiveregulationofcold-inducedthermogenesispositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialtubeformationpositiveregulationofERK1andERK2cascadepositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofhistonedeacetylaseactivitypositiveregulationofleukocytemigrationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmastcellchemotaxispositiveregulationofneuroblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofpositivechemotaxispositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinkinaseCsignalingpositiveregulationofproteinkinaseDsignalingpositiveregulationofproteinlocalizationtoearlyendosomepositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorinternalizationpositiveregulationofretinalganglioncellaxonguidancepositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftrophoblastcellmigrationpositiveregulationofvascularpermeabilitypost-embryoniccamera-typeeyedevelopmentprimitiveerythrocytedifferentiationregulationofcellshaperegulationofnitricoxidemediatedsignaltransductionregulationofretinalganglioncellaxonguidanceregulationoftranscriptionbyRNApolymeraseIIresponsetohypoxiasproutingangiogenesissurfactanthomeostasistubeformationvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorreceptor-2signalingpathwayvascularendothelialgrowthfactorsignalingpathwayvascularwoundhealingvasculogenesisVEGF-activatedneuropilinsignalingpathway
Serine protease 1
64
Pancreatic trypsin inhibitor
49
8.8
95
0.12
TRY1BPT1P00760P00974digestionproteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
NKG2-D type II integral membrane protein
112
NKG2-D type II integral membrane protein
121
6.2
82
0.2
NKG2DNKG2DO54709O54709adaptiveimmuneresponsecelldifferentiationcellularresponsetolipopolysaccharidedefenseresponsetoGram-positivebacteriumnaturalkillercellactivationnaturalkillercellmediatedcytotoxicitynegativeregulationofGTPaseactivitynegativeregulationofnaturalkillercellchemotaxisnitricoxidebiosyntheticprocesspositiveregulationofapoptoticprocesspositiveregulationofinterferon-gammaproductionpositiveregulationofmyeloiddendriticcellactivationpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationofnitricoxidebiosyntheticprocessstimulatoryC-typelectinreceptorsignalingpathway
Pygopus homolog 1
346
Pygopus homolog 1
343
8.3
65
0.18
PYGO1PYGO1Q9Y3Y4Q9Y3Y4canonicalWntsignalingpathwayhematopoieticprogenitorcelldifferentiationkidneydevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationtonucleusspermatidnucleusdifferentiation
Growth/differentiation factor 5
400
Growth/differentiation factor 5
465
9.8
77
0.13
GDF5GDF5P43026P43026BMPsignalingpathwaycell-cellsignalingchondroblastdifferentiationchondrocytedifferentiationembryoniclimbmorphogenesisforelimbmorphogenesishindlimbmorphogenesismesenchymalcellapoptoticprocessnegativeregulationofchondrocytedifferentiationnegativeregulationofepithelialcellproliferationnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofneuronapoptoticprocessossificationinvolvedinboneremodelingpositiveregulationofBMPsignalingpathwaypositiveregulationofchondrocytedifferentiationpositiveregulationofneurondifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationregulationofmulticellularorganismgrowthregulationofSMADproteinsignaltransductionresponsetomechanicalstimulusSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Peroxynitrite isomerase THAP4
483
Peroxynitrite isomerase THAP4
483
3.4
86
0.34
THAP4THAP4Q8WY91Q8WY91nitratemetabolicprocesstyrosinemetabolicprocess
Rho guanine nucleotide exchange factor TIAM2
592
Rho guanine nucleotide exchange factor TIAM2
564
9.7
67
0.15
TIAM2TIAM2Q6ZPF3Q6ZPF3activationofGTPaseactivitypositiveregulationofaxonogenesissmallGTPasemediatedsignaltransduction
Trypsin
33
Trypsin
181
9.6
79
0.13
TRYPTRYPP00761P00761digestionproteolysis
Mothers against decapentaplegic homolog 4
16
Mothers against decapentaplegic homolog 4
25
8.3
60
0.2
SMAD4SMAD4P97471P97471adrenalglanddevelopmentaginganatomicalstructuremorphogenesisanterior/posteriorpatternspecificationatrioventricularcanaldevelopmentatrioventricularvalveformationaxonguidanceBMPsignalingpathwaybrainstemdevelopmentbranchinginvolvedinuretericbudmorphogenesiscardiacseptumdevelopmentcelldifferentiationcellpopulationproliferationcellularironionhomeostasiscellularresponsetoglucosestimulusdevelopmentalgrowthembryonicdigitmorphogenesisendocardialcelldifferentiationendodermdevelopmentendothelialcellactivationepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationERK1andERK2cascadefemalegonaddevelopmentfemalegonadmorphogenesisformationofanatomicalboundarygastrulationgastrulationwithmouthformingsecondinuteroembryonicdevelopmentinterleukin-6-mediatedsignalingpathwayintracellularsignaltransductionkidneydevelopmentleftventricularcardiacmuscletissuemorphogenesismalegonaddevelopmentmesendodermdevelopmentmesodermdevelopmentmetanephricmesenchymemorphogenesisnegativeregulationofcardiacmusclehypertrophynegativeregulationofcardiacmyofibrilassemblynegativeregulationofcelldeathnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofERK1andERK2cascadenegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednephrogenicmesenchymemorphogenesisneuralcrestcelldifferentiationneuronfatecommitmentosteoblastdifferentiationoutflowtractseptummorphogenesisovarianfollicledevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcellproliferationinvolvedinheartvalvemorphogenesispositiveregulationofepithelialtomesenchymaltransitionpositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofhistoneH3-K4methylationpositiveregulationofhistoneH3-K9acetylationpositiveregulationofluteinizinghormonesecretionpositiveregulationofmiRNAtranscriptionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationofbindingregulationofcellpopulationproliferationregulationofhairfollicledevelopmentregulationoftranscriptionbyRNApolymeraseIIregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetotransforminggrowthfactorbetasebaceousglanddevelopmentsecondarypalatedevelopmentseminiferoustubuledevelopmentsinglefertilizationSMADproteincomplexassemblySMADproteinsignaltransductionsomiterostral/caudalaxisspecificationspermatogenesistissuemorphogenesistranscriptionbyRNApolymeraseIItranscriptionDNA-templatedtransforminggrowthfactorbetareceptorsignalingpathwayuterusdevelopmentventricularseptummorphogenesiswoundhealing
Protein S100-A4
76
Protein S100-A4
76
9.9
78
0.13
S10A4S10A4P26447P26447epithelialtomesenchymaltransitionpositiveregulationofI-kappaBkinase/NF-kappaBsignaling
Platelet factor 4
83
Platelet factor 4
83
8.6
75
0.16
PLF4PLF4P02776P02776adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaycytokine-mediatedsignalingpathwaydefenseresponsetoprotozoaninflammatoryresponsekillingbyhostofsymbiontcellskillingofcellsofanotherorganismleukocytechemotaxisnegativeregulationofangiogenesisnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofmegakaryocytedifferentiationnegativeregulationofMHCclassIIbiosyntheticprocessneutrophilchemotaxisplateletactivationpositiveregulationofgeneexpressionpositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofmacrophagedifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionregulationofcellpopulationproliferation
DNA-directed RNA polymerase, mitochondrial
591
Dimethyladenosine transferase 2, mitochondrial
383
10.0
46
0.22
RPOMTFB2MO00411Q9H5Q4mitochondrialtranscriptiontranscriptioninitiationfrommitochondrialpromoterrRNAmethylation
Early activation antigen CD69
85
Early activation antigen CD69
85
8.6
67
0.17
CD69CD69Q07108Q07108cellularresponsetoxenobioticstimulus
RNA 5'-monophosphate methyltransferase
248
RNA 5'-monophosphate methyltransferase
248
8.7
77
0.15
BN3D2BN3D2Q7Z5W3Q7Z5W3miRNAmetabolicprocessnegativeregulationofpre-miRNAprocessingpre-miRNAprocessingRNAmethylationtRNAmethylation
NKG2-D type II integral membrane protein
112
NKG2-D type II integral membrane protein
126
9.6
78
0.13
NKG2DNKG2DO54709O54709adaptiveimmuneresponsecelldifferentiationcellularresponsetolipopolysaccharidedefenseresponsetoGram-positivebacteriumnaturalkillercellactivationnaturalkillercellmediatedcytotoxicitynegativeregulationofGTPaseactivitynegativeregulationofnaturalkillercellchemotaxisnitricoxidebiosyntheticprocesspositiveregulationofapoptoticprocesspositiveregulationofinterferon-gammaproductionpositiveregulationofmyeloiddendriticcellactivationpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationofnitricoxidebiosyntheticprocessstimulatoryC-typelectinreceptorsignalingpathway
Bone marrow stromal antigen 2
63
Bone marrow stromal antigen 2
63
6.8
77
0.19
BST2BST2Q10589Q10589BcellactivationdefenseresponsetovirusinnateimmuneresponsenegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofintracellulartransportofviralmaterialnegativeregulationofplasmacytoiddendriticcellcytokineproductionnegativeregulationofviralgenomereplicationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofleukocyteproliferationregulationofactincytoskeletonorganizationresponsetointerferon-alpharesponsetointerferon-betaresponsetointerferon-gammaresponsetovirus
C-type lectin domain family 2 member D
80
C-type lectin domain family 2 member D
80
8.4
68
0.17
CLC2DCLC2DQ91V08Q91V08cellulardefenseresponsenegativeregulationofosteoclastdifferentiationprotectionfromnaturalkillercellmediatedcytotoxicity
Growth/differentiation factor 8
314
Growth/differentiation factor 8
340
6.7
63
0.24
GDF8GDF8O08689O08689cellularresponsetodexamethasonestimulusmusclecellcellularhomeostasismyoblastmigrationinvolvedinskeletalmuscleregenerationnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofkinaseactivitynegativeregulationofmusclehypertrophynegativeregulationofmyoblastdifferentiationnegativeregulationofmyoblastproliferationnegativeregulationofproteinkinaseBsignalingnegativeregulationofsatellitecelldifferentiationnegativeregulationofskeletalmusclesatellitecellproliferationnegativeregulationofskeletalmuscletissuegrowthovulationcycleprocesspositiveregulationoflamellipodiumassemblypositiveregulationofmacrophagechemotaxispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionDNA-templatedresponsetoelectricalstimulusresponsetoestrogenresponsetoethanolresponsetogravityresponsetoheatresponsetomuscleactivityresponsetotestosteroneskeletalmuscleatrophySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Bone morphogenetic protein 2
329
Bone morphogenetic protein 2
360
8.5
76
0.16
BMP2BMP2P12643P12643ameloblastdifferentiationanimalorganmorphogenesisaorticvalvedevelopmentastrocytedifferentiationatrioventricularcanalmorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwayBMPsignalingpathwayinvolvedinheartdevelopmentBMPsignalingpathwayinvolvedinheartinductionbonemineralizationbonemineralizationinvolvedinbonematurationbranchinginvolvedinuretericbudmorphogenesiscardiacatriumformationcardiacepithelialtomesenchymaltransitioncardiacjellydevelopmentcardiacmusclecelldifferentiationcardiacmuscletissuemorphogenesiscardiocytedifferentiationcellfatecommitmentcell-cellsignalingcellularresponsetoBMPstimuluscellularresponsetoorganiccycliccompoundchondrocytedifferentiationcorticotropinhormonesecretingcelldifferentiationembryonichearttubeanterior/posteriorpatternspecificationendocardialcushionformationendocardialcushionmorphogenesisepithelialtomesenchymaltransitionheartdevelopmentinuteroembryonicdevelopmentinflammatoryresponseinnereardevelopmentmesenchymalcelldifferentiationmesenchymalcellproliferationinvolvedinuretericbuddevelopmentmesenchymedevelopmentnegativeregulationofaldosteronebiosyntheticprocessnegativeregulationofcalcium-independentcell-celladhesionnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcardiacmusclecelldifferentiationnegativeregulationofcellcyclenegativeregulationofcellpopulationproliferationnegativeregulationofcortisolbiosyntheticprocessnegativeregulationofgeneexpressionnegativeregulationofinsulin-likegrowthfactorreceptorsignalingpathwaynegativeregulationofMAPkinaseactivitynegativeregulationofsmoothmusclecellproliferationnegativeregulationofsteroidbiosyntheticprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofWntsignalingpathwayinvolvedinheartdevelopmentNotchsignalingpathwayodontogenesisofdentin-containingtoothosteoblastdifferentiationpathway-restrictedSMADproteinphosphorylationpericardiumdevelopmentpositiveregulationofapoptoticprocesspositiveregulationofastrocytedifferentiationpositiveregulationofbonemineralizationpositiveregulationofcartilagedevelopmentpositiveregulationofcellmigrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcelldifferentiationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixconstituentsecretionpositiveregulationoffatcelldifferentiationpositiveregulationofgeneexpressionpositiveregulationofMAPKcascadepositiveregulationofmiRNAtranscriptionpositiveregulationofneurondifferentiationpositiveregulationofodontogenesispositiveregulationofossificationpositiveregulationofosteoblastdifferentiationpositiveregulationofosteoblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofperoxisomeproliferatoractivatedreceptorsignalingpathwaypositiveregulationofphosphataseactivitypositiveregulationofproteinbindingpositiveregulationofproteinphosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimuluspositiveregulationoftranscriptionDNA-templatedpositiveregulationofWntsignalingpathwaypositiveregulationofWntsignalingpathwaybyBMPsignalingpathwayproteindestabilizationproteinphosphorylationproteoglycanmetabolicprocessregulationofodontogenesisofdentin-containingtoothregulationoftranscriptionDNA-templatedresponsetobacteriumresponsetohypoxiaskeletalsystemdevelopmentSMADproteinsignaltransductiontelencephalondevelopmenttelencephalonregionalizationthyroid-stimulatinghormone-secretingcelldifferentiationtranscriptionbyRNApolymeraseIIWntsignalingpathway
Isoform L-VEGF206 of Vascular endothelial growth factor A
310
Isoform L-VEGF206 of Vascular endothelial growth factor A
257
9.6
60
0.17
VEGFAVEGFAP15692-14P15692-14
Trypsin-3
121
Amyloid-beta precursor protein
300
8.4
96
0.12
TRY3A4P35030P05067antimicrobialhumoralresponsedigestionendothelialcellmigrationproteolysiszymogenactivationadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Ubiquitin-conjugating enzyme E2 R1
93
Ubiquitin-conjugating enzyme E2 R1
93
8.4
79
0.15
UB2R1UB2R1P49427P49427cellularresponsetointerferon-betaDNAreplicationinitiationG1/StransitionofmitoticcellcyclenegativeregulationofcAMP-mediatedsignalingpositiveregulationofinclusionbodyassemblypositiveregulationofneuronapoptoticprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinK48-linkedubiquitinationproteinmodificationprocessproteinpolyubiquitinationproteinubiquitinationresponsetogrowthfactorubiquitin-dependentproteincatabolicprocess
Golgi reassembly-stacking protein 1
173
Golgin subfamily A member 2
984
7.9
56
0.23
GORS1GOGA2Q9BQQ3Q08379establishmentofproteinlocalizationtoplasmamembraneGolgiorganizationnegativeregulationofdendritemorphogenesisproteinN-linkedglycosylationproteintransportasymmetriccelldivisioncentrosomecycleendoplasmicreticulumtoGolgivesicle-mediatedtransportGolgidisassemblyGolgiribbonformationmeioticspindleassemblymicrotubulenucleationmitoticspindleassemblynegativeregulationofautophagynegativeregulationofproteinbindingpositiveregulationofproteinglycosylationproteinglycosylationproteinhomotetramerizationspindleassembly
Insulin
31
Insulin
84
9.3
59
0.18
A6XGL2A6XGL2A6XGL2A6XGL2glucosemetabolicprocess
A disintegrin and metalloproteinase with thrombospondin motifs 4
482
A disintegrin and metalloproteinase with thrombospondin motifs 4
482
7.6
74
0.18
ATS4ATS4O75173O75173extracellularmatrixdisassemblyextracellularmatrixorganizationproteolysisskeletalsystemdevelopment
Trypsin
205
Trypsin
181
7.4
69
0.19
TRYPTRYPP00761P00761digestionproteolysis
RNA 5'-monophosphate methyltransferase
249
RNA 5'-monophosphate methyltransferase
249
4.7
80
0.27
BN3D2BN3D2Q7Z5W3Q7Z5W3miRNAmetabolicprocessnegativeregulationofpre-miRNAprocessingpre-miRNAprocessingRNAmethylationtRNAmethylation
Defensin-6
99
Defensin-6
99
6.5
64
0.24
DEF6DEF6Q01524Q01524antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosakillingofcellsofanotherorganismmembranedisruptioninanotherorganism
SOSS complex subunit B1
99
SOSS complex subunit B1
99
9.0
nan
nan
SOSB1SOSB1Q9BQ15Q9BQ15cellularresponsetoDNAdamagestimulusDNArepairdouble-strandbreakrepairviahomologousrecombinationestablishmentofproteinlocalizationtotelomeremitoticG2/Mtransitioncheckpointpositiveregulationoftelomerecappingresponsetoionizingradiation
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
414
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
408
9.1
79
0.14
PDE10PDE10Q9Y233Q9Y233cAMPcatabolicprocesscGMPcatabolicprocessnegativeregulationofcGMP-mediatedsignalingsignaltransduction
Neutrophil defensin 1
68
Neutrophil defensin 1
73
8.0
73
0.17
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismmodificationbyhostofsymbiontmembraneTcellchemotaxis
Fractalkine
32
Fractalkine
74
7.9
60
0.21
X3CL1X3CL1P78423P78423agingangiogenesisinvolvedinwoundhealingautocrinesignalingcelladhesioncellchemotaxiscell-celladhesioncell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytokine-mediatedsignalingpathwaydefenseresponseeosinophilchemotaxisextrinsicapoptoticsignalingpathwayinabsenceofligandGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseintegrinactivationleukocyteadhesiveactivationleukocytechemotaxisleukocytemigrationinvolvedininflammatoryresponselymphocytechemotaxismicroglialcellactivationmicroglialcellproliferationmonocytechemotaxisnegativeregulationofapoptoticprocessnegativeregulationofapoptoticsignalingpathwaynegativeregulationofcellmigrationnegativeregulationofcell-substrateadhesionnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofglutamatereceptorsignalingpathwaynegativeregulationofhippocampalneuronapoptoticprocessnegativeregulationofinterleukin-1alphaproductionnegativeregulationofinterleukin-1betaproductionnegativeregulationofinterleukin-6productionnegativeregulationofmicroglialcellactivationnegativeregulationofneuronmigrationnegativeregulationoftumornecrosisfactorproductionneuroncellularhomeostasisneuronremodelingneutrophilchemotaxispositivechemotaxispositiveregulationofactinfilamentbundleassemblypositiveregulationofcalcium-independentcell-celladhesionpositiveregulationofcellpopulationproliferationpositiveregulationofcell-matrixadhesionpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofI-kappaBphosphorylationpositiveregulationofinflammatoryresponsepositiveregulationofMAPKcascadepositiveregulationofmicroglialcellmigrationpositiveregulationofneuroblastproliferationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftransforminggrowthfactorbeta1productionregulationoflipopolysaccharide-mediatedsignalingpathwayregulationofneurogenesisregulationofsynapticplasticityresponsetoischemiasynapsepruning
Intercellular adhesion molecule 1
332
Intercellular adhesion molecule 1
332
9.1
73
0.15
ICAM1ICAM1P05362P05362adhesionofsymbionttohostcelladhesioncelladhesionmediatedbyintegrincellularresponsetoamyloid-betacellularresponsetoglucosestimuluscellularresponsetoleukemiainhibitoryfactorestablishmentofendothelialbarrierheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesleukocytecell-celladhesionleukocytemigrationmembranetomembranedockingnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorspositiveregulationofcellularextravasationpositiveregulationofERK1andERK2cascadereceptor-mediatedvirionattachmenttohostcellregulationofleukocytemediatedcytotoxicityregulationofruffleassemblyTcellactivationviaTcellreceptorcontactwithantigenboundtoMHCmoleculeonantigenpresentingcellTcellantigenprocessingandpresentationTcellextravasation
Glutamate receptor 2
78
Glutamate receptor 4
331
8.0
74
0.17
GRIA2GRIA4P19491P19493chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumionmodulationofchemicalsynaptictransmissionnegativeregulationofsmoothmusclecellapoptoticprocesspositiveregulationofsynaptictransmissionglutamatergicregulationofsynapsestructureoractivity
Estrogen receptor
227
Estrogen receptor
237
7.6
68
0.19
ESR1ESR1P03372P03372androgenmetabolicprocessantralovarianfolliclegrowthcellularresponsetoestradiolstimuluscellularresponsetoestrogenstimuluschromatinremodelingepithelialcelldevelopmentepithelialcellproliferationinvolvedinmammaryglandductelongationfibroblastproliferationintracellularestrogenreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaymalegonaddevelopmentmammaryglandalveolusdevelopmentmammaryglandbranchinginvolvedinpregnancynegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofgeneexpressionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofmiRNAmaturationnegativeregulationoftranscriptionbyRNApolymeraseIIphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoffibroblastproliferationpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofphospholipaseCactivitypositiveregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprostateepithelialcordarborizationinvolvedinprostateglandularacinusmorphogenesisprostateepithelialcordelongationproteinlocalizationtochromatinregulationofbranchinginvolvedinprostateglandmorphogenesisregulationofepithelialcellapoptoticprocessregulationofinflammatoryresponseregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetoestradiolresponsetoestrogensignaltransductionstemcelldifferentiationtranscriptionbyRNApolymeraseIIuterusdevelopmentvaginadevelopment
PRSS3 protein
52
Amyloid-beta A4 protein
222
9.3
100
0.11
Q8N2U3H7C0V9Q8N2U3H7C0V9proteolysisnervoussystemdevelopment
Kinesin light chain 2
221
Kinesin light chain 2
221
6.5
77
0.2
KLC2KLC2Q9H0B6Q9H0B6lysosomelocalizationmicrotubule-basedmovement
General transcription factor IIH subunit 3
142
General transcription factor IIH subunit 2
348
6.5
84
0.18
TF2H3TF2H2Q13889Q13888DNArepairnucleotide-excisionrepairphosphorylationofRNApolymeraseIIC-terminaldomaintranscriptionbyRNApolymeraseIIGprotein-coupledreceptorinternalizationpositiveregulationofDNAhelicaseactivityregulationoftranscriptionbyRNApolymeraseIIresponsetoUVtranscriptioninitiationfromRNApolymeraseIIpromoter
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
172
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
172
6.5
nan
nan
GLCNEGLCNEQ9Y223Q9Y223celladhesionN-acetylglucosaminebiosyntheticprocessN-acetylneuraminatemetabolicprocessUDP-N-acetylglucosaminemetabolicprocess
Mitochondrial antiviral-signaling protein
79
Mitochondrial antiviral-signaling protein
20
9.3
52
0.21
MAVSMAVSQ7Z434Q7Z434activationofinnateimmuneresponsecellularresponsetoexogenousdsRNAdefenseresponsetobacteriumdefenseresponsetovirusinnateimmuneresponsenegativeregulationofviralgenomereplicationpositiveregulationofchemokine(C-Cmotif)ligand5productionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofIP-10productionpositiveregulationofmyeloiddendriticcellcytokineproductionpositiveregulationofproteinimportintonucleuspositiveregulationofproteinphosphorylationpositiveregulationofresponsetocytokinestimuluspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIinterferon-mediatedsignalingpathwayregulationofperoxisomeorganizationsignaltransductiontypeIinterferonsignalingpathway
Low affinity immunoglobulin epsilon Fc receptor
288
Low affinity immunoglobulin epsilon Fc receptor
288
6.3
69
0.23
FCER2FCER2P06734P06734positiveregulationofhumoralimmuneresponsemediatedbycirculatingimmunoglobulinpositiveregulationofkillingofcellsofanotherorganismpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofnitric-oxidesynthasebiosyntheticprocess
General transcription factor IIH subunit 3
142
General transcription factor IIH subunit 2
345
6.3
72
0.22
TF2H3TF2H2Q13889Q13888DNArepairnucleotide-excisionrepairphosphorylationofRNApolymeraseIIC-terminaldomaintranscriptionbyRNApolymeraseIIGprotein-coupledreceptorinternalizationpositiveregulationofDNAhelicaseactivityregulationoftranscriptionbyRNApolymeraseIIresponsetoUVtranscriptioninitiationfromRNApolymeraseIIpromoter
Fibrinogen gamma chain
35
Fibrinogen gamma chain
35
6.0
49
0.34
FIBGFIBGP02679P02679bloodcoagulationfibrinclotformationcell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetointerleukin-6fibrinolysisnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofplateletaggregationplasminogenactivationplateletaggregationplateletmaturationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationproteinsecretionprotein-containingcomplexassemblyresponsetocalciumion
Caspase-2
179
Caspase-2
399
5.2
53
0.36
CASP2CASP2P42575P42575activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessagingapoptoticprocessapoptoticsignalingpathwaybraindevelopmentcellularresponsetoDNAdamagestimuluscellularresponsetomechanicalstimulusDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestectopicgermcellprogrammedcelldeathexecutionphaseofapoptosisextrinsicapoptoticsignalingpathwayinabsenceofligandintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageluteolysisnegativeregulationofapoptoticprocessnegativeregulationofnecroptoticprocessneuralretinadevelopmentpositiveregulationofapoptoticprocesspositiveregulationofapoptoticsignalingpathwaypositiveregulationofneuronapoptoticprocessproteinprocessingreleaseofcytochromecfrommitochondria
Mothers against decapentaplegic homolog 2
463
Mothers against decapentaplegic homolog 4
523
8.4
71
0.17
SMAD2SMAD4Q15796Q13485activinreceptorsignalingpathwayadrenalglanddevelopmentanatomicalstructuremorphogenesisanterior/posteriorpatternspecificationBMPsignalingpathwaycelldifferentiationcellfatecommitmentcommon-partnerSMADproteinphosphorylationembryoniccranialskeletonmorphogenesisembryonicforegutmorphogenesisendodermformationgastrulationinuteroembryonicdevelopmentinsulinsecretionintracellularsignaltransductionlungdevelopmentmesodermformationnegativeregulationofcellpopulationproliferationnegativeregulationoftranscriptionDNA-templatednodalsignalingpathwayorgangrowthpancreasdevelopmentparaxialmesodermmorphogenesispericardiumdevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofgeneexpressionpositiveregulationofnodalsignalingpathwayinvolvedindeterminationoflateralmesodermleft/rightasymmetrypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpost-embryonicdevelopmentprimarymiRNAprocessingregulationofbindingregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoglucosesecondarypalatedevelopmentsignaltransductioninvolvedinregulationofgeneexpressionSMADproteincomplexassemblySMADproteinsignaltransductiontranscriptionDNA-templatedtransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentwoundhealingzygoticspecificationofdorsal/ventralaxisagingatrioventricularcanaldevelopmentatrioventricularvalveformationaxonguidancebrainstemdevelopmentbranchinginvolvedinuretericbudmorphogenesiscardiacconductionsystemdevelopmentcellpopulationproliferationcellularironionhomeostasiscellularresponsetoBMPstimuluscellularresponsetoglucosestimulusdevelopmentalgrowthembryonicdigitmorphogenesisendocardialcelldifferentiationendothelialcellactivationepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationERK1andERK2cascadefemalegonadmorphogenesisformationofanatomicalboundarygastrulationwithmouthformingsecondinterleukin-6-mediatedsignalingpathwayleftventricularcardiacmuscletissuemorphogenesismesendodermdevelopmentmetanephricmesenchymemorphogenesisnegativeregulationofcardiacmusclehypertrophynegativeregulationofcardiacmyofibrilassemblynegativeregulationofcelldeathnegativeregulationofcellgrowthnegativeregulationofERK1andERK2cascadenegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInephrogenicmesenchymemorphogenesisneuralcrestcelldifferentiationneuronfatecommitmentosteoblastdifferentiationoutflowtractseptummorphogenesisovarianfollicledevelopmentpositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcellproliferationinvolvedinheartvalvemorphogenesispositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofhistoneH3-K4methylationpositiveregulationofhistoneH3-K9acetylationpositiveregulationofluteinizinghormonesecretionpositiveregulationofmiRNAtranscriptionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimuluspositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationofhairfollicledevelopmentregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetotransforminggrowthfactorbetasebaceousglanddevelopmentseminiferoustubuledevelopmentsinglefertilizationsomiterostral/caudalaxisspecificationspermatogenesistranscriptionbyRNApolymeraseIIuterusdevelopmentventricularseptummorphogenesis
Protein unc-13 homolog A
5
Regulating synaptic membrane exocytosis protein 2
116
8.4
85
0.14
UN13ARIMS2Q62768Q9JIS1amyloid-betametabolicprocesscelldifferentiationdensecoregranulepriminginnervationlong-termsynapticpotentiationneuromuscularjunctiondevelopmentneuronaldensecorevesicleexocytosisneurotransmittersecretionpositiveregulationofdendriteextensionpositiveregulationofglutamatereceptorsignalingpathwaypositiveregulationofneurotransmittersecretionpositiveregulationofsynapticplasticitypresynapticdensecorevesicleexocytosisregulationofamyloidprecursorproteincatabolicprocessregulationofshort-termneuronalsynapticplasticityregulationofsynapticvesicleprimingsynaptictransmissionglutamatergicsynapticvesicledockingsynapticvesicleexocytosissynapticvesiclematurationsynapticvesicleprimingadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycalciumion-regulatedexocytosisofneurotransmittercalcium-ionregulatedexocytosisexocytosisinsulinsecretionintracellularproteintransportpositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofgeneexpressionpositiveregulationofinhibitorypostsynapticpotentialpositiveregulationofsynaptictransmissionregulationofexocytosisregulationofmembranepotentialregulationofsynapticplasticityspontaneousneurotransmittersecretion
Fibrinogen beta chain
110
Fibrinogen gamma chain
35
5.5
72
0.25
FIBBFIBGP02675P02679adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Geminin coiled-coil domain-containing protein 1
122
Geminin coiled-coil domain-containing protein 1
122
5.4
41
0.45
GEMC1GEMC1A6NCL1A6NCL1cellcycleciliumassemblyDNAreplicationinitiationnegativeregulationofcellcyclenegativeregulationofDNAreplication
Glycoprotein hormones alpha chain
111
Follitropin subunit beta
50
9.8
74
0.14
GLHAFSHBP01215P01225follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationfemalegametegenerationfemalepregnancypositiveregulationofboneresorptionpositiveregulationofgeneexpressionprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationSertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Aldo-keto reductase family 1 member C21
7
Aldo-keto reductase family 1 member C21
7
9.1
79
0.14
AK1CLAK1CLQ91WR5Q91WR5daunorubicinmetabolicprocessdoxorubicinmetabolicprocessprogesteronemetabolicprocessprostaglandinmetabolicprocesssteroidbiosyntheticprocesssteroidmetabolicprocess
Platelet factor 4
67
Platelet factor 4
27
8.4
75
0.16
PLF4PLF4P02777P02777adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaycytokine-mediatedsignalingpathwayinflammatoryresponseleukocytechemotaxisnegativeregulationofangiogenesisnegativeregulationofmegakaryocytedifferentiationneutrophilchemotaxisplateletactivationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellpopulationproliferation
Mitotic spindle assembly checkpoint protein MAD2B
144
DNA polymerase zeta catalytic subunit
1999
10.0
60
0.17
MD2L2REV3LQ9UI95O60673actinfilamentorganizationcelldivisionDNAdamageresponsesignaltransductionresultingintranscriptiondouble-strandbreakrepairerror-pronetranslesionsynthesismitoticspindleassemblycheckpointsignalingnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofdouble-strandbreakrepairviahomologousrecombinationnegativeregulationofepithelialtomesenchymaltransitionnegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbycompetitivepromoterbindingnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionregulatoryregionDNAbindingnegativeregulationofubiquitinproteinligaseactivitypositiveregulationofdouble-strandbreakrepairvianonhomologousendjoiningpositiveregulationofisotypeswitchingpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationoftranscriptionDNA-templatedregulationofcellgrowthsomaticdiversificationofimmunoglobulinsinvolvedinimmuneresponsetelomeremaintenanceinresponsetoDNAdamageDNA-templatedDNAreplicationdouble-strandbreakrepairviahomologousrecombination
Geminin coiled-coil domain-containing protein 1
73
Geminin coiled-coil domain-containing protein 1
73
3.9
42
0.62
GEMC1GEMC1A6NCL1A6NCL1cellcycleciliumassemblyDNAreplicationinitiationnegativeregulationofcellcyclenegativeregulationofDNAreplication
Neutrophil defensin 1
66
Neutrophil defensin 1
73
9.7
64
0.16
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismmodificationbyhostofsymbiontmembraneTcellchemotaxis
5'-AMP-activated protein kinase catalytic subunit alpha-1
425
5'-AMP-activated protein kinase subunit beta-1
194
8.9
51
0.22
AAPK1AAKB1Q13131Q9Y478autophagybileacidandbilesalttransportbileacidsignalingpathwayCAMKK-AMPKsignalingcascadecellularresponsetocalciumioncellularresponsetoethanolcellularresponsetoglucosestarvationcellularresponsetoglucosestimuluscellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetonutrientlevelscellularresponsetoorganonitrogencompoundcellularresponsetooxidativestresscellularresponsetoprostaglandinEstimuluscellularresponsetoxenobioticstimuluscholesterolbiosyntheticprocesschromatinorganizationcoldacclimationenergyhomeostasisfattyacidbiosyntheticprocessfattyacidhomeostasisfattyacidoxidationglucosehomeostasisglucosemetabolicprocessintracellularsignaltransductionlipidbiosyntheticprocesslipiddropletdisassemblymotorbehaviornegativeregulationofapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofglucosylceramidebiosyntheticprocessnegativeregulationofhepatocyteapoptoticprocessnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationoflipidcatabolicprocessnegativeregulationofTORsignalingnegativeregulationoftubulindeacetylationneuroncellularhomeostasispositiveregulationofautophagypositiveregulationofcellpopulationproliferationpositiveregulationofcholesterolbiosyntheticprocesspositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofmitochondrialtranscriptionpositiveregulationofpeptidyl-lysineacetylationpositiveregulationofproteinlocalizationpositiveregulationofproteintargetingtomitochondrionpositiveregulationofskeletalmuscletissuedevelopmentproteinlocalizationtolipiddropletproteinphosphorylationregulationofbileacidsecretionregulationofcircadianrhythmregulationofmicrotubulecytoskeletonorganizationregulationofpeptidyl-serinephosphorylationregulationofstressgranuleassemblyregulationofvesicle-mediatedtransportresponseto17alpha-ethynylestradiolresponsetoactivityresponsetocaffeineresponsetocamptothecinresponsetogammaradiationresponsetohypoxiaresponsetoUVrhythmicprocesssignaltransductionWntsignalingpathwaynaildevelopmentpositiveregulationofcold-inducedthermogenesisregulationofcatalyticactivity
Neutrophil defensin 1
66
Neutrophil defensin 1
68
7.1
64
0.22
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismmodificationbyhostofsymbiontmembraneTcellchemotaxis
Coagulation factor VII
77
Tissue factor
241
9.1
nan
nan
FA7TFP08709P13726activationofbloodcoagulationviaclottingcascadeanimalorganregenerationbloodcoagulationbloodcoagulationextrinsicpathwaybloodcoagulationfibrinclotformationbloodcoagulationintrinsicpathwaycircadianrhythmpositiveregulationofbloodcoagulationpositiveregulationofcellmigrationpositiveregulationofleukocytechemotaxispositiveregulationofplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofpositivechemotaxispositiveregulationofproteinkinaseBsignalingproteinprocessingproteolysisresponseto2378-tetrachlorodibenzodioxineresponsetoanticoagulantresponsetoastaxanthinresponsetocarbondioxideresponsetocholesterolresponsetoestradiolresponsetoestrogenresponsetogenisteinresponsetogrowthhormoneresponsetohypoxiaresponsetoThyroidstimulatinghormoneresponsetothyrotropin-releasinghormoneresponsetothyroxineresponsetovitaminKresponsetowoundingzymogenactivationactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofplasmaproteinsinvolvedinacuteinflammatoryresponsecytokine-mediatedsignalingpathwaypositiveregulationofangiogenesispositiveregulationofendothelialcellproliferationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-8production
Neutrophil defensin 3
66
Neutrophil defensin 3
68
6.3
nan
nan
DEF3DEF3P59666P59666antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetovirusinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Hepcidin
73
Neutrophil gelatinase-associated lipocalin
76
3.4
78
0.38
HEPCNGALP81172P80188acute-phaseresponseagingantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularironionhomeostasiscellularresponsetobileacidcellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactorcellularresponsetoX-raydefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumestablishmentoflocalizationincellimmuneresponseironiontransmembranetransportkillingofcellsofanotherorganismliverregenerationmacrophageactivationmulticellularorganismalironionhomeostasismyeloidcellhomeostasisnegativeregulationofboneresorptionnegativeregulationofinflammatoryresponsenegativeregulationofintestinalabsorptionnegativeregulationofiontransmembranetransporteractivitynegativeregulationofironexportacrossplasmamembranenegativeregulationofironiontransmembranetransportnegativeregulationofironiontransmembranetransporteractivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofmacrophageactivationpositiveregulationofproteincatabolicprocesspositiveregulationofproteinpolyubiquitinationpositiveregulationofreceptorcatabolicprocesspositiveregulationofreceptorinternalizationpositiveregulationoftranscriptionbyRNApolymeraseIIproteincatabolicprocessreceptorsignalingpathwayviaJAK-STATresponsetoerythropoietinresponsetoethanolresponsetoironionresponsetoironionstarvationresponsetovitaminAresponsetozinciontranscriptionbyRNApolymeraseIIapoptoticprocessinnateimmuneresponsepositiveregulationofcold-inducedthermogenesissequesteringofironionsiderophoretransport
Interleukin-18
104
Interleukin-18
104
3.7
77
0.35
IL18IL18Q14116Q14116activationofproteinkinaseBactivityangiogenesiscellpopulationproliferationcell-cellsignalingcellularresponsetoorganiccycliccompoundcholesterolhomeostasisdefenseresponsetoGram-positivebacteriumestablishmentofskinbarrierinflammatoryresponseinterleukin-18-mediatedsignalingpathwaylipopolysaccharide-mediatedsignalingpathwayMAPKcascadenaturalkillercellactivationnaturalkillercellmediatedcytotoxicitynegativeregulationofmyoblastdifferentiationneutrophilactivationNIK/NF-kappaBsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofchemokineproductionpositiveregulationofcold-inducedthermogenesispositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-13productionpositiveregulationofinterleukin-17productionpositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofnaturalkillercellproliferationpositiveregulationofneuroinflammatoryresponsepositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofNKTcellproliferationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofsmoothmusclecellproliferationpositiveregulationofT-helper1cellcytokineproductionpositiveregulationofT-helper2celldifferentiationpositiveregulationoftissueremodelingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofcelladhesionsleepT-helper1typeimmuneresponsetriglyceridehomeostasistype2immuneresponse
Cartilage oligomeric matrix protein
71
Cartilage oligomeric matrix protein
71
9.1
49
0.22
COMPCOMPP35444P35444apoptoticprocessarterymorphogenesisbloodcoagulationBMPsignalingpathwaybonegrowthbonemineralizationbonemorphogenesiscartilagedevelopmentcartilagehomeostasischondrocytedevelopmentchondrocyteproliferationcollagenfibrilorganizationendochondralbonegrowthgrowthplatecartilagedevelopmentlimbdevelopmentmulticellularorganismagingmulticellularorganismgrowthmusclecelldevelopmentmusculoskeletalmovementnegativeregulationofapoptoticprocessnegativeregulationofhemostasisneuromuscularprocessossificationplateletaggregationpositiveregulationofchondrocyteproliferationproteinhomooligomerizationproteinprocessingproteinsecretionregulationofbonemineralizationregulationofgeneexpressionresponsetounfoldedproteinskeletalsystemdevelopmentskindevelopmenttendondevelopmentvascularassociatedsmoothmusclecelldevelopmentvascularassociatedsmoothmusclecontraction
Hepcidin
69
Neutrophil gelatinase-associated lipocalin
76
10.0
80
0.13
HEPCNGALP81172P80188acute-phaseresponseagingantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularironionhomeostasiscellularresponsetobileacidcellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactorcellularresponsetoX-raydefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumestablishmentoflocalizationincellimmuneresponseironiontransmembranetransportkillingofcellsofanotherorganismliverregenerationmacrophageactivationmulticellularorganismalironionhomeostasismyeloidcellhomeostasisnegativeregulationofboneresorptionnegativeregulationofinflammatoryresponsenegativeregulationofintestinalabsorptionnegativeregulationofiontransmembranetransporteractivitynegativeregulationofironexportacrossplasmamembranenegativeregulationofironiontransmembranetransportnegativeregulationofironiontransmembranetransporteractivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofmacrophageactivationpositiveregulationofproteincatabolicprocesspositiveregulationofproteinpolyubiquitinationpositiveregulationofreceptorcatabolicprocesspositiveregulationofreceptorinternalizationpositiveregulationoftranscriptionbyRNApolymeraseIIproteincatabolicprocessreceptorsignalingpathwayviaJAK-STATresponsetoerythropoietinresponsetoethanolresponsetoironionresponsetoironionstarvationresponsetovitaminAresponsetozinciontranscriptionbyRNApolymeraseIIapoptoticprocessinnateimmuneresponsepositiveregulationofcold-inducedthermogenesissequesteringofironionsiderophoretransport
Lymphocyte antigen 6 complex locus protein G6d
96
Lymphocyte antigen 6 complex locus protein G6d
96
3.7
73
0.37
LY66DLY66DO95868O95868acetylcholinereceptorsignalingpathway
Hepcidin
81
Neutrophil gelatinase-associated lipocalin
76
5.5
77
0.24
HEPCNGALP81172P80188acute-phaseresponseagingantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularironionhomeostasiscellularresponsetobileacidcellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactorcellularresponsetoX-raydefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumestablishmentoflocalizationincellimmuneresponseironiontransmembranetransportkillingofcellsofanotherorganismliverregenerationmacrophageactivationmulticellularorganismalironionhomeostasismyeloidcellhomeostasisnegativeregulationofboneresorptionnegativeregulationofinflammatoryresponsenegativeregulationofintestinalabsorptionnegativeregulationofiontransmembranetransporteractivitynegativeregulationofironexportacrossplasmamembranenegativeregulationofironiontransmembranetransportnegativeregulationofironiontransmembranetransporteractivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofmacrophageactivationpositiveregulationofproteincatabolicprocesspositiveregulationofproteinpolyubiquitinationpositiveregulationofreceptorcatabolicprocesspositiveregulationofreceptorinternalizationpositiveregulationoftranscriptionbyRNApolymeraseIIproteincatabolicprocessreceptorsignalingpathwayviaJAK-STATresponsetoerythropoietinresponsetoethanolresponsetoironionresponsetoironionstarvationresponsetovitaminAresponsetozinciontranscriptionbyRNApolymeraseIIapoptoticprocessinnateimmuneresponsepositiveregulationofcold-inducedthermogenesissequesteringofironionsiderophoretransport
DNA repair protein RAD52 homolog
25
DNA repair protein RAD52 homolog
25
9.3
nan
nan
RAD52RAD52P43351P43351cellularresponsetoDNAdamagestimuluscellularresponsetooxidativestressDNAdouble-strandbreakprocessinginvolvedinrepairviasingle-strandannealingDNArecombinaseassemblyDNArecombinationdouble-strandbreakrepairdouble-strandbreakrepairviahomologousrecombinationdouble-strandbreakrepairviasingle-strandannealingmitoticrecombinationregulationofnucleotide-excisionrepair
Oxidized low-density lipoprotein receptor 1
144
Oxidized low-density lipoprotein receptor 1
144
9.8
67
0.15
OLR1OLR1P78380P78380bloodcirculationcelldeathimmunesystemprocessinflammatoryresponseleukocytecell-celladhesionlipoproteinmetabolicprocessproteolysis
Integrin alpha-IIb
959
Integrin beta-3
689
9.4
nan
nan
ITA2BITB3Q17R67P05106angiogenesiscelladhesionmediatedbyintegrincell-celladhesioncell-matrixadhesionintegrin-mediatedsignalingpathwayactivationofproteinkinaseactivityangiogenesisinvolvedinwoundhealingapolipoproteinA-I-mediatedsignalingpathwayapoptoticcellclearancebloodcoagulationcelladhesioncellmigrationcell-substrateadhesioncell-substratejunctionassemblycellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetomechanicalstimuluscellularresponsetoplatelet-derivedgrowthfactorstimuluscellularresponsetoxenobioticstimulusembryoimplantationheterotypiccell-celladhesionmesodermalcelldifferentiationnegativechemotaxisnegativeregulationofcelldeathnegativeregulationoflipidstoragenegativeregulationoflipidtransportnegativeregulationoflipoproteinmetabolicprocessnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofmacrophagederivedfoamcelldifferentiationplateletactivationplateletaggregationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofadenylatecyclase-inhibitingopioidreceptorsignalingpathwaypositiveregulationofangiogenesispositiveregulationofboneresorptionpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofosteoblastproliferationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofTcellmigrationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofactincytoskeletonorganizationregulationofboneresorptionregulationofextracellularmatrixorganizationregulationofpostsynapticneurotransmitterreceptorinternalizationregulationofproteinlocalizationregulationofproteintyrosinekinaseactivityregulationofreleaseofsequesteredcalciumionintocytosolregulationofserotoninuptakeregulationoftrophoblastcellmigrationresponsetoactivityresponsetoradiationsmoothmusclecellmigrationsubstrateadhesion-dependentcellspreadingtubedevelopmentviralentryintohostcellwoundhealing
Dynamin-binding protein
300
Dynamin-binding protein
300
5.3
55
0.34
DNMBPDNMBPQ6XZF7Q6XZF7agingintracellularsignaltransductionregulationofcellshaperegulationofsmallGTPasemediatedsignaltransduction
Guanine nucleotide exchange factor DBS
952
Guanine nucleotide exchange factor DBS
952
6.8
41
0.36
MCF2LMCF2LQ64096Q64096positiveregulationofRhoproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIRhoproteinsignaltransduction
Lymphocyte antigen 6 complex locus protein G6d
96
Lymphocyte antigen 6 complex locus protein G6d
102
5.3
66
0.29
LY66DLY66DO95868O95868acetylcholinereceptorsignalingpathway
Hepcidin
72
Neutrophil gelatinase-associated lipocalin
76
9.8
79
0.13
HEPCNGALP81172P80188acute-phaseresponseagingantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularironionhomeostasiscellularresponsetobileacidcellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactorcellularresponsetoX-raydefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumestablishmentoflocalizationincellimmuneresponseironiontransmembranetransportkillingofcellsofanotherorganismliverregenerationmacrophageactivationmulticellularorganismalironionhomeostasismyeloidcellhomeostasisnegativeregulationofboneresorptionnegativeregulationofinflammatoryresponsenegativeregulationofintestinalabsorptionnegativeregulationofiontransmembranetransporteractivitynegativeregulationofironexportacrossplasmamembranenegativeregulationofironiontransmembranetransportnegativeregulationofironiontransmembranetransporteractivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofmacrophageactivationpositiveregulationofproteincatabolicprocesspositiveregulationofproteinpolyubiquitinationpositiveregulationofreceptorcatabolicprocesspositiveregulationofreceptorinternalizationpositiveregulationoftranscriptionbyRNApolymeraseIIproteincatabolicprocessreceptorsignalingpathwayviaJAK-STATresponsetoerythropoietinresponsetoethanolresponsetoironionresponsetoironionstarvationresponsetovitaminAresponsetozinciontranscriptionbyRNApolymeraseIIapoptoticprocessinnateimmuneresponsepositiveregulationofcold-inducedthermogenesissequesteringofironionsiderophoretransport
Immunoglobulin heavy constant gamma 1
109
Immunoglobulin heavy constant gamma 1
112
9.3
nan
nan
IGHG1IGHG1P01857P01857adaptiveimmuneresponseantibody-dependentcellularcytotoxicityBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Hepcidin
82
Neutrophil gelatinase-associated lipocalin
76
8.7
69
0.17
HEPCNGALP81172P80188acute-phaseresponseagingantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularironionhomeostasiscellularresponsetobileacidcellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactorcellularresponsetoX-raydefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumestablishmentoflocalizationincellimmuneresponseironiontransmembranetransportkillingofcellsofanotherorganismliverregenerationmacrophageactivationmulticellularorganismalironionhomeostasismyeloidcellhomeostasisnegativeregulationofboneresorptionnegativeregulationofinflammatoryresponsenegativeregulationofintestinalabsorptionnegativeregulationofiontransmembranetransporteractivitynegativeregulationofironexportacrossplasmamembranenegativeregulationofironiontransmembranetransportnegativeregulationofironiontransmembranetransporteractivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofmacrophageactivationpositiveregulationofproteincatabolicprocesspositiveregulationofproteinpolyubiquitinationpositiveregulationofreceptorcatabolicprocesspositiveregulationofreceptorinternalizationpositiveregulationoftranscriptionbyRNApolymeraseIIproteincatabolicprocessreceptorsignalingpathwayviaJAK-STATresponsetoerythropoietinresponsetoethanolresponsetoironionresponsetoironionstarvationresponsetovitaminAresponsetozinciontranscriptionbyRNApolymeraseIIapoptoticprocessinnateimmuneresponsepositiveregulationofcold-inducedthermogenesissequesteringofironionsiderophoretransport
Store-operated calcium entry-associated regulatory factor
320
Store-operated calcium entry-associated regulatory factor
97
8.7
61
0.19
SARAFSARAFQ96BY9Q96BY9calciumiontransportregulationofstore-operatedcalciumentry
Trypsin-3
253
Tissue factor pathway inhibitor
171
9.0
100
0.11
TRY3TFPI1P35030P10646antimicrobialhumoralresponsedigestionendothelialcellmigrationproteolysiszymogenactivationbloodcoagulationcellularresponsetosteroidhormonestimulusnegativeregulationofbloodcoagulation
Lymphocyte antigen 6 complex locus protein G6d
102
Lymphocyte antigen 6 complex locus protein G6d
102
6.5
60
0.26
LY66DLY66DO95868O95868acetylcholinereceptorsignalingpathway
Spindle assembly abnormal protein 6 homolog
310
Spindle assembly abnormal protein 6 homolog
310
3.3
31
0.97
SAS6SAS6Q6UVJ0Q6UVJ0centriolereplicationcentrosomeduplicationpositiveregulationofcentriolereplicationpositiveregulationofG1/Stransitionofmitoticcellcyclepositiveregulationofspindleassemblyregulationofmitoticspindleorganization
Beta-microseminoprotein
22
Beta-microseminoprotein
22
8.3
57
0.21
MSMBMSMBP08118P08118
Immunoglobulin heavy constant gamma 1
308
Immunoglobulin heavy constant gamma 1
349
9.9
79
0.13
IGHG1IGHG1P01857P01857adaptiveimmuneresponseantibody-dependentcellularcytotoxicityBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
If kappa light chain
219
Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region
128
7.9
nan
nan
A2NHM3Q811U5A2NHM3Q811U5
Neutrophil defensin 1
66
Neutrophil defensin 1
66
4.3
77
0.3
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismmodificationbyhostofsymbiontmembraneTcellchemotaxis
PRSS3 protein
52
Amyloid-beta A4 protein
17
8.4
97
0.12
Q8N2U3H7C0V9Q8N2U3H7C0V9proteolysisnervoussystemdevelopment
PRSS3 protein
224
Amyloid-beta A4 protein
34
9.7
83
0.12
Q8N2U3H7C0V9Q8N2U3H7C0V9proteolysisnervoussystemdevelopment
Adhesion G protein-coupled receptor B1
461
Adhesion G protein-coupled receptor B1
446
9.8
32
0.32
AGRB1AGRB1Q3UHD1Q3UHD1adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayapoptoticcellclearancecellsurfacereceptorsignalingpathwaydefenseresponsetoGram-negativebacteriumengulfmentofapoptoticcellinnateimmuneresponsemuscleorgandevelopmentnegativeregulationofangiogenesisnegativeregulationofendothelialcellmigrationnegativeregulationofproteincatabolicprocessnegativeregulationofproteinubiquitinationnervoussystemdevelopmentphagocytosisengulfmentphagocytosisrecognitionpositiveregulationofmyoblastfusionpositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofsynapseassemblypostsynapticactincytoskeletonorganizationregulationofsynapseassemblyregulationofsynapticplasticity
PRSS3 protein
52
Amyloid-beta A4 protein
34
9.7
94
0.11
Q8N2U3H7C0V9Q8N2U3H7C0V9proteolysisnervoussystemdevelopment
Glycoprotein hormones alpha chain
31
Follitropin subunit beta
21
9.3
nan
nan
GLHAFSHBP01215P01225follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationfemalegametegenerationfemalepregnancypositiveregulationofboneresorptionpositiveregulationofgeneexpressionprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationSertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Isoform A of Ketohexokinase
98
Isoform A of Ketohexokinase
32
8.0
77
0.16
KHKKHKP50053-2P50053-2
Immunoglobulin heavy constant gamma 1
356
Immunoglobulin heavy constant gamma 1
250
9.4
70
0.15
IGHG1IGHG1P01857P01857adaptiveimmuneresponseantibody-dependentcellularcytotoxicityBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Macrophage migration inhibitory factor
60
Macrophage migration inhibitory factor
110
7.2
75
0.18
MIFMIFP14174P14174carboxylicacidmetabolicprocesscellsurfacereceptorsignalingpathwaycellularsenescenceDNAdamageresponsesignaltransductionbyp53classmediatorinflammatoryresponseinnateimmuneresponsenegativeregulationofapoptoticprocessnegativeregulationofcellmigrationnegativeregulationofcellularsenescencenegativeregulationofDNAdamageresponsesignaltransductionbyp53classmediatornegativeregulationofgeneexpressionnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatornegativeregulationofmacrophagechemotaxisnegativeregulationofmatureBcellapoptoticprocessnegativeregulationofmyeloidcellapoptoticprocessnegativeregulationofproteinmetabolicprocesspositiveregulationofarachidonicacidsecretionpositiveregulationofBcellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofchemokine(C-X-Cmotif)ligand2productionpositiveregulationofcytokineproductionpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofMAPkinaseactivitypositiveregulationofmyeloidleukocytecytokineproductioninvolvedinimmuneresponsepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphorylationpositiveregulationofprostaglandinsecretioninvolvedinimmuneresponsepositiveregulationofproteinkinaseAsignalingpositiveregulationoftumornecrosisfactorproductionprostaglandinbiosyntheticprocessproteinhomotrimerizationregulationofmacrophageactivation
Egl nine homolog 1
323
Hypoxia-inducible factor 1-alpha
412
9.9
75
0.13
EGLN1HIF1AQ9GZT9Q16665cardiacmuscletissuemorphogenesiscellularironionhomeostasiscellularresponsetohypoxiahearttrabeculaformationlabyrinthinelayerdevelopmentnegativeregulationofcyclic-nucleotidephosphodiesteraseactivitynegativeregulationofDNA-bindingtranscriptionfactoractivityoxygenhomeostasispeptidyl-prolinehydroxylationto4-hydroxy-L-prolinepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofangiogenesisregulationofneurondeathregulationofpostsynapseorganizationregulationofproteincatabolicprocessatpostsynapsemodulatingsynaptictransmissionresponsetohypoxiaresponsetonitricoxideventricularseptummorphogenesisangiogenesisaxonaltransportofmitochondrionB-1Bcellhomeostasisbonemineralizationcardiacventriclemorphogenesiscellularglucosehomeostasiscellularresponsetointerleukin-1cellularresponsetoviruscerebralcortexdevelopmentchondrocytedifferentiationcollagenmetabolicprocessconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingdigestivetractmorphogenesisdopaminergicneurondifferentiationelastinmetabolicprocessembryonichemopoiesisembryonicplacentadevelopmentepithelialcelldifferentiationinvolvedinmammaryglandalveolusdevelopmentepithelialtomesenchymaltransitionglandularepithelialcellmaturationheartloopinghemoglobinbiosyntheticprocesshypoxia-induciblefactor-1alphasignalingpathwayinsulinsecretioninvolvedincellularresponsetoglucosestimulusintestinalepithelialcellmaturationirismorphogenesislactatemetabolicprocesslactationmesenchymalcellapoptoticprocessmusclecellcellularhomeostasisnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofgrowthnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofthymocyteapoptoticprocessnegativeregulationofTORsignalingneuralcrestcellmigrationneuralfoldelevationformationneuroblastproliferationneuronapoptoticprocessoutflowtractmorphogenesispositiveregulationofangiogenesispositiveregulationofautophagyofmitochondrionpositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofchemokineproductionpositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellmigrationpositiveregulationoferythrocytedifferentiationpositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhormonebiosyntheticprocesspositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofmacroautophagypositiveregulationofmiRNAtranscriptionpositiveregulationofneuroblastproliferationpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofsignalingreceptoractivitypositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofaerobicrespirationregulationofgeneexpressionregulationofglycolyticprocessregulationofproteinneddylationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetooxidativestressregulationoftranscriptionDNA-templatedregulationoftransforminggrowthfactorbeta2productionresponsetoironionresponsetomuscleactivityresponsetoreactiveoxygenspeciesretinavasculaturedevelopmentincamera-typeeyesignaltransductionTORsignalingvascularendothelialgrowthfactorproductionvisuallearning
Human nkt tcr alpha chain
80
Human nkt tcr beta chain
176
9.8
66
0.15
K7N5M3K7N5M4K7N5M3K7N5M4
Cytochrome c oxidase assembly factor 6 homolog
90
Cytochrome c oxidase assembly factor 6 homolog
59
9.8
65
0.16
COA6COA6Q5JTJ3Q5JTJ3mitochondrialATPsynthesiscoupledelectrontransportplasmamembraneATPsynthesiscoupledelectrontransportrespiratorychaincomplexIVassembly
Lysozyme C
99
Lysozyme C
64
9.2
86
0.13
LYSCLYSCP61626P61626antimicrobialhumoralresponsecytolysisdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminflammatoryresponsekillingofcellsofanotherorganismmetabolicprocessretinahomeostasis
Defensin alpha 5
65
Defensin alpha 5
65
6.6
69
0.22
DEF5DEF5Q01523Q01523antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismpositiveregulationofinterleukin-8productionpositiveregulationofmembranepermeabilityproteinhomotetramerization
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
545
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
545
9.8
74
0.14
MAGI1MAGI1Q6RHR9Q6RHR9positiveregulationofcell-celladhesionsignaltransduction
Glutamate receptor 3
312
Glutamate receptor 3
85
9.3
nan
nan
GRIA3GRIA3P19492P19492regulationofreceptorrecyclingresponsetofungicideresponsetolithiumion
Leukocyte immunoglobulin-like receptor subfamily A member 2
142
Leukocyte immunoglobulin-like receptor subfamily A member 2
195
9.6
78
0.13
LIRA2LIRA2Q8N149Q8N149cytokine-mediatedsignalingpathwaydefenseresponseinnateimmuneresponseinnateimmuneresponseactivatingcellsurfacereceptorsignalingpathwaynegativeregulationoflipopolysaccharide-mediatedsignalingpathwaynegativeregulationoftoll-likereceptor4signalingpathwayneutrophilactivationinvolvedinimmuneresponsepositiveregulationofcalciumiontransportpositiveregulationofcellactivationpositiveregulationofgranulocytecolony-stimulatingfactorproductionpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationoftumornecrosisfactorproductionsignaltransduction
Ribonuclease pancreatic
123
Ribonuclease pancreatic
32
9.4
61
0.17
RNAS1RNAS1P07998P07998defenseresponsetoGram-positivebacteriumRNAphosphodiesterbondhydrolysis
Integrin alpha-X
920
Integrin beta-2
670
9.5
63
0.17
ITAXITB2P20702P05107animalorganmorphogenesiscelladhesioncelladhesionmediatedbyintegrincell-celladhesioncell-matrixadhesiondefenseresponsetovirusheterotypiccell-celladhesionintegrin-mediatedsignalingpathwaypositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialtubemorphogenesispositiveregulationofgeneexpressionpositiveregulationofmyelinationamyloid-betaclearanceapoptoticprocesscellmigrationcell-celladhesionviaplasma-membraneadhesionmoleculescell-cellsignalingcellularresponsetolow-densitylipoproteinparticlestimulusendodermalcelldifferentiationinflammatoryresponseleukocytecell-celladhesionmicroglialcellactivationnegativeregulationofdopaminemetabolicprocessneutrophilchemotaxisneutrophilmigrationphagocytosisengulfmentpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofneurondeathpositiveregulationofneutrophildegranulationpositiveregulationofprostaglandin-Esynthaseactivitypositiveregulationofproteintargetingtomembranepositiveregulationofsuperoxideaniongenerationreceptorclusteringreceptorinternalizationreceptor-mediatedendocytosisregulationofcellshaperegulationofpeptidyl-tyrosinephosphorylation
Vam6/Vps39-like protein
852
Vam6/Vps39-like protein
852
7.1
51
0.27
VPS39VPS39Q96JC1Q96JC1autophagosome-lysosomefusionautophagyendocyticrecyclingendosomalvesiclefusionendosometolysosometransportintracellularproteintransportlateendosometolysosometransportregulationofSNAREcomplexassembly
Defensin alpha 4
65
Defensin alpha 4
67
8.1
65
0.19
DEF4DEF4P12838P12838antibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideantimicrobialhumoralresponsecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingofcellsofanotherorganismmembranedisruptioninanotherorganismTcellchemotaxis
Neutrophil defensin 3
68
Neutrophil defensin 3
68
7.0
69
0.21
DEF3DEF3P59666P59666antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetovirusinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Histone-lysine N-methyltransferase 2C
1136
Histone-lysine N-methyltransferase 2C
1136
9.6
38
0.28
KMT2CKMT2CQ8NEZ4Q8NEZ4chromatinorganizationhistoneH3-K4methylationhistoneH3-K4monomethylationpositiveregulationoftranscriptionbyRNApolymeraseII
Secreted frizzled-related protein 3
35
Secreted frizzled-related protein 3
35
8.8
56
0.2
SFRP3SFRP3P97401P97401canonicalWntsignalingpathwaycochleamorphogenesisconvergentextensioninvolvedinorganogenesisepithelialcelldevelopmenthepatocytedifferentiationinnerearmorphogenesisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcartilagedevelopmentnegativeregulationofcelldevelopmentnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofhepatocytedifferentiationnegativeregulationofWntsignalingpathwayneuralcrestcelldifferentiationpositiveregulationofapoptoticprocesspositiveregulationoffatcelldifferentiationsomitedevelopment
Inhibitor of nuclear factor kappa-B kinase subunit alpha
658
Inhibitor of nuclear factor kappa-B kinase subunit alpha
658
7.5
50
0.27
IKKAIKKAO15111O15111anatomicalstructuremorphogenesiscellularresponsetocadmiumioncellularresponsetoreactiveoxygenspeciescellularresponsetotumornecrosisfactorcellularresponsetovirusI-kappaBkinase/NF-kappaBsignalingI-kappaBphosphorylationimmuneresponseinflammatoryresponseinnateimmuneresponsenegativeregulationofNF-kappaBtranscriptionfactoractivityNIK/NF-kappaBsignalingpeptidyl-serinephosphorylationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterferon-alphaproductionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedproteinphosphorylationresponsetovirustumornecrosisfactor-mediatedsignalingpathway
Glycoprotein hormones alpha chain
31
Follitropin subunit beta
21
9.8
52
0.2
Q96QJ4FSHBQ96QJ4P01225femalegametegenerationfemalepregnancyfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwaypositiveregulationofboneresorptionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationregulationofsignalingreceptoractivitySertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Insulin
109
Insulin
43
6.5
nan
nan
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
Cartilage oligomeric matrix protein
68
Cartilage oligomeric matrix protein
71
8.6
nan
nan
COMPCOMPQ9R0G6Q9R0G6apoptoticprocessarterymorphogenesisbloodcoagulationBMPsignalingpathwaybonegrowthbonemineralizationbonemorphogenesiscartilagedevelopmentcartilagehomeostasischondrocytedevelopmentchondrocyteproliferationcollagenfibrilorganizationendochondralbonegrowthgrowthplatecartilagedevelopmentlimbdevelopmentmulticellularorganismagingmulticellularorganismgrowthmusclecelldevelopmentmusculoskeletalmovementnegativeregulationofapoptoticprocessnegativeregulationofhemostasisneuromuscularprocessossificationplateletaggregationpositiveregulationofchondrocyteproliferationproteinhomooligomerizationproteinprocessingproteinsecretionregulationofbonemineralizationregulationofgeneexpressionresponsetounfoldedproteinskeletalsystemdevelopmentskindevelopmenttendondevelopmentvascularassociatedsmoothmusclecelldevelopmentvascularassociatedsmoothmusclecontraction
RB1-inducible coiled-coil protein 1
1565
RB1-inducible coiled-coil protein 1
925
8.5
53
0.22
RBCC1RBCC1Q8TDY2Q8TDY2autophagosomeassemblyautophagyautophagyofmitochondrionautophagyofperoxisomecellcycleextrinsicapoptoticsignalingpathwayglycophagyheartdevelopmentliverdevelopmentnegativeregulationofcellpopulationproliferationnegativeregulationofextrinsicapoptoticsignalingpathwaypiecemealmicroautophagyofthenucleuspositiveregulationofautophagypositiveregulationofcellsizepositiveregulationofJNKcascadepositiveregulationofproteinphosphorylationproteinautophosphorylationproteinphosphorylationregulationofproteinlipidationreticulophagy
Kinesin-like protein KIF21A
1006
Kinesin-like protein KIF21A
1421
8.6
69
0.17
KI21AKI21AQ7Z4S6Q7Z4S6microtubule-basedmovement
Histone-lysine N-methyltransferase 2C
1057
Histone-lysine N-methyltransferase 2C
1057
4.1
66
0.37
KMT2CKMT2CQ8NEZ4Q8NEZ4chromatinorganizationhistoneH3-K4methylationhistoneH3-K4monomethylationpositiveregulationoftranscriptionbyRNApolymeraseII
Kappa-type opioid receptor
345
Kappa-type opioid receptor
345
8.0
50
0.25
OPRKOPRKP41145P41145adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingopioidreceptorsignalingpathwaybehavioralresponsetococainecellularresponsetoglucosestimuluscellularresponsetolipopolysaccharidechemicalsynaptictransmissionconditionedplacepreferencedefenseresponsetoviruseatingbehaviorestrouscycleGprotein-coupledopioidreceptorsignalingpathwayimmuneresponselocomotorybehaviormaternalbehaviornegativeregulationofluteinizinghormonesecretionneuropeptidesignalingpathwayphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofdopaminesecretionpositiveregulationofeatingbehaviorpositiveregulationoflocomotionpositiveregulationofp38MAPKcascadepositiveregulationofpotassiumiontransmembranetransportregulationofsalivasecretionregulationofsensoryperceptionofpainresponsetoacrylamideresponsetoestrogenresponsetoethanolresponsetoinsulinresponsetomorphineresponsetoradiationsensoryperceptionsensoryperceptionofpainsensoryperceptionoftemperaturestimulus
ATPase WRNIP1
20
ATPase WRNIP1
39
9.1
45
0.24
WRIP1WRIP1Q96S55Q96S55DNAsynthesisinvolvedinDNArepairDNA-templatedDNAreplicationinnateimmuneresponseregulationofDNArepairregulationofDNA-templatedDNAreplicationinitiation
Trypsin-3
105
Tissue factor pathway inhibitor
267
8.6
97
0.12
TRY3TFPI1P35030P10646antimicrobialhumoralresponsedigestionendothelialcellmigrationproteolysiszymogenactivationbloodcoagulationcellularresponsetosteroidhormonestimulusnegativeregulationofbloodcoagulation
Neutrophil defensin 3
83
Neutrophil defensin 3
66
9.0
nan
nan
DEF3DEF3P59666P59666antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetovirusinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Low affinity immunoglobulin epsilon Fc receptor
160
Low affinity immunoglobulin epsilon Fc receptor
160
9.9
30
0.34
FCER2FCER2P06734P06734positiveregulationofhumoralimmuneresponsemediatedbycirculatingimmunoglobulinpositiveregulationofkillingofcellsofanotherorganismpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofnitric-oxidesynthasebiosyntheticprocess
Caspase-3
220
Caspase-3
264
3.3
86
0.36
CASP3CASP3P42574P42574anteriorneuraltubeclosureapoptoticprocessapoptoticsignalingpathwayaxonalfasciculationBcellhomeostasiscellfatecommitmentcellularresponsetoDNAdamagestimuluscellularresponsetostaurosporineepithelialcellapoptoticprocesserythrocytedifferentiationexecutionphaseofapoptosisfibroblastapoptoticprocessglialcellapoptoticprocessheartdevelopmenthippocampusdevelopmentintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoosmoticstresskeratinocytedifferentiationlearningormemoryleukocyteapoptoticprocessluteolysisnegativeregulationofactivatedTcellproliferationnegativeregulationofapoptoticprocessnegativeregulationofBcellproliferationneuronapoptoticprocessneurondifferentiationneurotrophinTRKreceptorsignalingpathwayplateletformationpositiveregulationofamyloid-betaformationpositiveregulationofapoptoticDNAfragmentationpositiveregulationofapoptoticprocesspositiveregulationofneuronapoptoticprocessproteincatabolicprocessproteinprocessingproteolysisregulationofmacroautophagyregulationofproteinstabilityresponsetoaminoacidresponsetoantibioticresponsetocobaltionresponsetoestradiolresponsetoglucocorticoidresponsetoglucoseresponsetohydrogenperoxideresponsetohypoxiaresponsetolipopolysaccharideresponsetonicotineresponsetotumornecrosisfactorresponsetoUVresponsetoX-rayresponsetoxenobioticstimulussensoryperceptionofsoundstriatedmusclecelldifferentiationTcellhomeostasiswoundhealing
Guanylate cyclase soluble subunit alpha-1
595
Guanylate cyclase soluble subunit beta-1
476
3.7
76
0.35
GCYA1GCYB1Q02108Q02153bloodcirculationcGMPbiosyntheticprocesscGMP-mediatedsignalingnitricoxidemediatedsignaltransductionpositiveregulationofnitricoxidemediatedsignaltransductionregulationofbloodpressurerelaxationofvascularassociatedsmoothmuscleresponsetooxygenlevelsretrogradetrans-synapticsignalingbynitricoxidemodulatingsynaptictransmissioncellularresponsetonitricoxidenitricoxide-cGMP-mediatedsignalingpathwaytrans-synapticsignalingbynitricoxidemodulatingsynaptictransmission
Phosphoinositide 3-kinase adapter protein 1
284
Phosphoinositide 3-kinase adapter protein 1
284
7.4
nan
nan
BCAPBCAPQ6ZUJ8Q6ZUJ8positiveregulationofphosphatidylinositol3-kinasesignalingregulationofinflammatoryresponsetoll-likereceptor2signalingpathwaytoll-likereceptor4signalingpathwaytoll-likereceptor7signalingpathwaytoll-likereceptor9signalingpathway
LINE-1 retrotransposable element ORF1 protein
111
LINE-1 retrotransposable element ORF1 protein
111
4.0
47
0.53
LORF1LORF1Q15605Q15605transpositionRNA-mediated
Endothelin-1
67
Endothelin-1
53
3.8
58
0.45
EDN1EDN1P05305P05305adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayarterysmoothmusclecontractionaxonextensionaxonogenesisinvolvedininnervationbodyfluidsecretionbranchinginvolvedinbloodvesselmorphogenesiscalciumiontransmembranetransportcalcium-mediatedsignalingcanonicalWntsignalingpathwaycardiacneuralcrestcellmigrationinvolvedinoutflowtractmorphogenesiscartilagedevelopmentcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularcalciumionhomeostasiscellularresponsetocalciumioncellularresponsetofattyacidcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetohumanchorionicgonadotropinstimuluscellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoluteinizinghormonestimuluscellularresponsetomineralocorticoidstimuluscellularresponsetoorganicsubstancecellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetotumornecrosisfactorcellularresponsetoxenobioticstimulusdorsal/ventralpatternformationembryonichearttubedevelopmentendothelinreceptorsignalingpathwayendothelinreceptorsignalingpathwayinvolvedinheartprocessepithelialfluidtransportERK1andERK2cascadeGprotein-coupledreceptorsignalingpathwayhistaminesecretionI-kappaBkinase/NF-kappaBsignalinginuteroembryonicdevelopmentinositolphosphate-mediatedsignalingleukocyteactivationmaternalprocessinvolvedinparturitionmeioticcellcycleprocessinvolvedinoocytematurationmembranedepolarizationmiddleearmorphogenesismitochondrionorganizationmulticellularorganismagingnegativeregulationofbloodcoagulationnegativeregulationofgeneexpressionnegativeregulationofhormonesecretionnegativeregulationofnitric-oxidesynthasebiosyntheticprocessnegativeregulationofproteinmetabolicprocessnegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneuralcrestcellfatecommitmentnitricoxidetransportnoradrenergicneurondifferentiationpeptidehormonesecretionpharyngealarcharterymorphogenesisphosphatidylinositol3-kinasesignalingphospholipaseD-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcardiacmusclehypertrophypositiveregulationofcationchannelactivitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellsizepositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellmigrationpositiveregulationofheartratepositiveregulationofhormonesecretionpositiveregulationofJUNkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofmitoticnucleardivisionpositiveregulationofneutrophilchemotaxispositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofodontogenesispositiveregulationofprostaglandinsecretionpositiveregulationofprostaglandin-endoperoxidesynthaseactivitypositiveregulationofrenalsodiumexcretionpositiveregulationofsarcomereorganizationpositiveregulationofsignalingreceptoractivitypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsmoothmusclecontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofurinevolumepositiveregulationofvascularassociatedsmoothmusclecellproliferationprostaglandinbiosyntheticprocessproteinkinaseAsignalingproteinkinaseCdeactivationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteinphosphorylationregulationofglucosetransmembranetransportregulationofpHregulationofsensoryperceptionofpainregulationofsystemicarterialbloodpressurebyendothelinregulationofvasoconstrictionrenalsodiumionabsorptionrespiratorygaseousexchangebyrespiratorysystemresponsetoactivityresponsetoaminoacidresponsetoamphetamineresponsetodexamethasoneresponsetoleptinresponsetolipopolysaccharideresponsetomusclestretchresponsetonicotineresponsetoozoneresponsetoprostaglandinFresponsetosaltresponsetotestosteronerhythmicexcitationsemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesensoryperceptionofpainsuperoxideaniongenerationsympatheticneuronaxonguidancethyroidglanddevelopmenttranscriptionbyRNApolymeraseIIvasoconstrictionveinsmoothmusclecontraction
Endothelin-1
67
Endothelin-1
67
4.6
56
0.39
EDN1EDN1P05305P05305adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayarterysmoothmusclecontractionaxonextensionaxonogenesisinvolvedininnervationbodyfluidsecretionbranchinginvolvedinbloodvesselmorphogenesiscalciumiontransmembranetransportcalcium-mediatedsignalingcanonicalWntsignalingpathwaycardiacneuralcrestcellmigrationinvolvedinoutflowtractmorphogenesiscartilagedevelopmentcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularcalciumionhomeostasiscellularresponsetocalciumioncellularresponsetofattyacidcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetohumanchorionicgonadotropinstimuluscellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoluteinizinghormonestimuluscellularresponsetomineralocorticoidstimuluscellularresponsetoorganicsubstancecellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetotumornecrosisfactorcellularresponsetoxenobioticstimulusdorsal/ventralpatternformationembryonichearttubedevelopmentendothelinreceptorsignalingpathwayendothelinreceptorsignalingpathwayinvolvedinheartprocessepithelialfluidtransportERK1andERK2cascadeGprotein-coupledreceptorsignalingpathwayhistaminesecretionI-kappaBkinase/NF-kappaBsignalinginuteroembryonicdevelopmentinositolphosphate-mediatedsignalingleukocyteactivationmaternalprocessinvolvedinparturitionmeioticcellcycleprocessinvolvedinoocytematurationmembranedepolarizationmiddleearmorphogenesismitochondrionorganizationmulticellularorganismagingnegativeregulationofbloodcoagulationnegativeregulationofgeneexpressionnegativeregulationofhormonesecretionnegativeregulationofnitric-oxidesynthasebiosyntheticprocessnegativeregulationofproteinmetabolicprocessnegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneuralcrestcellfatecommitmentnitricoxidetransportnoradrenergicneurondifferentiationpeptidehormonesecretionpharyngealarcharterymorphogenesisphosphatidylinositol3-kinasesignalingphospholipaseD-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcardiacmusclehypertrophypositiveregulationofcationchannelactivitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellsizepositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellmigrationpositiveregulationofheartratepositiveregulationofhormonesecretionpositiveregulationofJUNkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofmitoticnucleardivisionpositiveregulationofneutrophilchemotaxispositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofodontogenesispositiveregulationofprostaglandinsecretionpositiveregulationofprostaglandin-endoperoxidesynthaseactivitypositiveregulationofrenalsodiumexcretionpositiveregulationofsarcomereorganizationpositiveregulationofsignalingreceptoractivitypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsmoothmusclecontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofurinevolumepositiveregulationofvascularassociatedsmoothmusclecellproliferationprostaglandinbiosyntheticprocessproteinkinaseAsignalingproteinkinaseCdeactivationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteinphosphorylationregulationofglucosetransmembranetransportregulationofpHregulationofsensoryperceptionofpainregulationofsystemicarterialbloodpressurebyendothelinregulationofvasoconstrictionrenalsodiumionabsorptionrespiratorygaseousexchangebyrespiratorysystemresponsetoactivityresponsetoaminoacidresponsetoamphetamineresponsetodexamethasoneresponsetoleptinresponsetolipopolysaccharideresponsetomusclestretchresponsetonicotineresponsetoozoneresponsetoprostaglandinFresponsetosaltresponsetotestosteronerhythmicexcitationsemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesensoryperceptionofpainsuperoxideaniongenerationsympatheticneuronaxonguidancethyroidglanddevelopmenttranscriptionbyRNApolymeraseIIvasoconstrictionveinsmoothmusclecontraction
Spondin-1
182
Spondin-1
182
8.3
63
0.19
SPON1SPON1Q9HCB6Q9HCB6celladhesionnegativeregulationofamyloid-betaformationpositiveregulationofamyloidprecursorproteincatabolicprocesspositiveregulationofproteinbindingpositiveregulationofproteinprocessingproteinprocessing
Activated CDC42 kinase 1
119
Activated CDC42 kinase 1
119
6.0
70
0.24
ACK1ACK1Q07912Q07912celldifferentiationcellsurfacereceptorsignalingpathwayendocytosisinnateimmuneresponsephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationregulationofclathrin-dependentendocytosissmallGTPasemediatedsignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
NF-kappa-B essential modulator
76
Inhibitor of nuclear factor kappa-B kinase subunit alpha
114
8.8
66
0.17
NEMOIKKAQ9Y6K9O15111anoikisapoptoticprocesscellularresponsetoDNAdamagestimulusestablishmentofvesiclelocalizationI-kappaBkinase/NF-kappaBsignalingimmuneresponseinflammatoryresponseinnateimmuneresponsenegativeregulationofneurondeathpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofmacroautophagypositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofTcellreceptorsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIprotein-containingcomplexassemblyregulationofI-kappaBkinase/NF-kappaBsignalingresponsetovirusTcellreceptorsignalingpathwayanatomicalstructuremorphogenesiscellularresponsetocadmiumioncellularresponsetoreactiveoxygenspeciescellularresponsetotumornecrosisfactorcellularresponsetovirusI-kappaBphosphorylationnegativeregulationofNF-kappaBtranscriptionfactoractivityNIK/NF-kappaBsignalingpeptidyl-serinephosphorylationpositiveregulationofinterferon-alphaproductionpositiveregulationoftranscriptionDNA-templatedproteinphosphorylationtumornecrosisfactor-mediatedsignalingpathway
Trypsin-3
277
Tissue factor pathway inhibitor
171
9.9
85
0.12
TRY3TFPI1P35030P10646antimicrobialhumoralresponsedigestionendothelialcellmigrationproteolysiszymogenactivationbloodcoagulationcellularresponsetosteroidhormonestimulusnegativeregulationofbloodcoagulation
Caspase-3
184
Caspase-3
264
9.8
90
0.11
CASP3CASP3P42574P42574anteriorneuraltubeclosureapoptoticprocessapoptoticsignalingpathwayaxonalfasciculationBcellhomeostasiscellfatecommitmentcellularresponsetoDNAdamagestimuluscellularresponsetostaurosporineepithelialcellapoptoticprocesserythrocytedifferentiationexecutionphaseofapoptosisfibroblastapoptoticprocessglialcellapoptoticprocessheartdevelopmenthippocampusdevelopmentintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoosmoticstresskeratinocytedifferentiationlearningormemoryleukocyteapoptoticprocessluteolysisnegativeregulationofactivatedTcellproliferationnegativeregulationofapoptoticprocessnegativeregulationofBcellproliferationneuronapoptoticprocessneurondifferentiationneurotrophinTRKreceptorsignalingpathwayplateletformationpositiveregulationofamyloid-betaformationpositiveregulationofapoptoticDNAfragmentationpositiveregulationofapoptoticprocesspositiveregulationofneuronapoptoticprocessproteincatabolicprocessproteinprocessingproteolysisregulationofmacroautophagyregulationofproteinstabilityresponsetoaminoacidresponsetoantibioticresponsetocobaltionresponsetoestradiolresponsetoglucocorticoidresponsetoglucoseresponsetohydrogenperoxideresponsetohypoxiaresponsetolipopolysaccharideresponsetonicotineresponsetotumornecrosisfactorresponsetoUVresponsetoX-rayresponsetoxenobioticstimulussensoryperceptionofsoundstriatedmusclecelldifferentiationTcellhomeostasiswoundhealing
Store-operated calcium entry-associated regulatory factor
320
Store-operated calcium entry-associated regulatory factor
83
9.6
59
0.18
SARAFSARAFQ96BY9Q96BY9calciumiontransportregulationofstore-operatedcalciumentry
Immunoglobulin heavy constant gamma 1
250
Immunoglobulin heavy constant gamma 1
112
9.2
73
0.15
IGHG1IGHG1P01857P01857adaptiveimmuneresponseantibody-dependentcellularcytotoxicityBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Trypsin-3
253
Tissue factor pathway inhibitor
267
9.9
103
0.1
TRY3TFPI1P35030P10646antimicrobialhumoralresponsedigestionendothelialcellmigrationproteolysiszymogenactivationbloodcoagulationcellularresponsetosteroidhormonestimulusnegativeregulationofbloodcoagulation
T-complex protein 1 subunit gamma
213
T-complex protein 1 subunit gamma
213
5.4
34
0.55
TCPGTCPGP80318P80318bindingofspermtozonapellucidachaperone-mediatedproteinfoldingporecomplexassemblypositiveregulationofestablishmentofproteinlocalizationtotelomerepositiveregulationoftelomeremaintenanceviatelomeraseproteinfoldingproteinstabilizationtoxintransport
Insulin-degrading enzyme
414
Islet amyloid polypeptide
35
8.3
63
0.19
IDEIAPPQ5T5N2P10997amyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessamyloid-betametabolicprocessantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIbradykinincatabolicprocessdeterminationofadultlifespanhormonecatabolicprocessinsulincatabolicprocessinsulinmetabolicprocessinsulinreceptorsignalingpathwaypeptidecatabolicprocesspositiveregulationofproteinbindingpositiveregulationofproteincatabolicprocessproteincatabolicprocessproteolysisproteolysisinvolvedinproteincatabolicprocessregulationofaerobicrespirationubiquitinrecyclingadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayamylinreceptorsignalingpathwayamyloidfibrilformationapoptoticprocessboneresorptioncell-cellsignalingeatingbehaviornegativeregulationofamyloidfibrilformationnegativeregulationofboneresorptionnegativeregulationofcellpopulationproliferationnegativeregulationofmitochondrionorganizationnegativeregulationofosteoclastdifferentiationnegativeregulationofprotein-containingcomplexassemblyosteoclastdifferentiationpositiveregulationofapoptoticprocesspositiveregulationofcalciumionimportacrossplasmamembranepositiveregulationofcelldeathpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofMAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingproteindestabilizationproteinhomooligomerizationsensoryperceptionofpainsignaltransduction
Mitochondrial import receptor subunit TOM20 homolog
100
Aldehyde dehydrogenase, mitochondrial
16
4.3
67
0.35
TOM20ALDH2Q62760P11884proteinimportintomitochondrialmatrixproteintargetingtomitochondrion"responseto335-triiodo-L-thyronine"responsetomuscleactivitytRNAimportintomitochondrionacetaldehydemetabolicprocessaldehydecatabolicprocessapoptoticmitochondrialchangesbehavioralresponsetoethanolcellulardetoxificationofaldehydecellularresponsetofattyacidcellularresponsetohormonestimuluscellularresponsetoresveratrolethanolcatabolicprocessethanolmetabolicprocessintrinsicapoptoticsignalingpathwayinresponsetooxidativestressliverdevelopmentnegativeregulationofapoptoticprocessregulationofdopaminebiosyntheticprocessregulationofinflammatoryresponseregulationofreactiveoxygenspeciesmetabolicprocessregulationofresponsetooxidativestressregulationofserotoninbiosyntheticprocessresponsetoestradiolresponsetoethanolresponsetoheatresponsetohyperoxiaresponsetoischemiaresponsetolipopolysaccharideresponsetonicotineresponsetoorganiccycliccompoundresponsetoprogesteroneresponsetotestosterone
Cyclin-T1
261
Cyclin-T1
261
9.2
nan
nan
CCNT1CCNT1O60563O60563cellcyclecelldivisionphosphorylationofRNApolymeraseIIC-terminaldomainserine2residuesinvolvedinpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterphosphorylationofRNApolymeraseIIC-terminaldomainserine5residuesinvolvedinpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterpositiveregulationbyhostofviraltranscriptionpositiveregulationofDNA-templatedtranscriptionelongationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterproteinphosphorylationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationoftranscriptionbyRNApolymeraseIIresponsetoxenobioticstimulustranscriptionbyRNApolymeraseII
Thioredoxin-dependent peroxide reductase, mitochondrial
78
Thioredoxin-dependent peroxide reductase, mitochondrial
78
3.5
88
0.32
PRDX3PRDX3P30048P30048cellredoxhomeostasiscellularresponsetooxidativestresscellularresponsetoreactiveoxygenspecieshydrogenperoxidecatabolicprocessmaternalplacentadevelopmentmitochondrionorganizationmyeloidcelldifferentiationnegativeregulationofapoptoticprocessnegativeregulationofkinaseactivitypeptidyl-cysteineoxidationpositiveregulationofcellpopulationproliferationpositiveregulationofNF-kappaBtranscriptionfactoractivityregulationofmitochondrialmembranepotentialresponsetohydrogenperoxideresponsetolipopolysaccharideresponsetooxidativestress
Echinoderm microtubule-associated protein-like 2
50
Echinoderm microtubule-associated protein-like 2
50
6.9
57
0.26
EMAL2EMAL2O95834O95834microtubulecytoskeletonorganizationnegativeregulationofmicrotubulepolymerizationregulationofmicrotubulenucleationsensoryperceptionofsoundvisualperception
Nitric oxide synthase, brain
96
Nitric oxide synthase, brain
96
4.0
63
0.4
NOS1NOS1P29476P29476agingargininecatabolicprocessbehavioralresponsetococainebraindevelopmentcellularresponsetoepinephrinestimuluscellularresponsetogrowthfactorstimuluscellularresponsetomechanicalstimulusestablishmentofproteinlocalizationfemalepregnancymulticellularorganismalresponsetostressmusclecontractionnegativeregulationofapoptoticprocessnegativeregulationofbloodpressurenegativeregulationofcalciumiontransportnegativeregulationofcellpopulationproliferationnegativeregulationofcytosoliccalciumionconcentrationnegativeregulationofheartcontractionnegativeregulationofhepaticstellatecellcontractionnegativeregulationofhydrolaseactivitynegativeregulationofinsulinsecretionnegativeregulationofironiontransmembranetransportnegativeregulationofneuronapoptoticprocessnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofpotassiumiontransportnegativeregulationofserotoninuptakenegativeregulationofvasoconstrictionnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionpeptidyl-cysteineS-nitrosylationpositiveregulationofadenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocesspositiveregulationofguanylatecyclaseactivitypositiveregulationofhistoneacetylationpositiveregulationoflong-termsynapticpotentiationpositiveregulationofneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsodiumiontransmembranetransportpositiveregulationoftheforceofheartcontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofheartcontractionregulationofneurogenesisregulationofsensoryperceptionofpainregulationofsodiumiontransportresponsetoactivityresponsetoestrogenresponsetoethanolresponsetoheatresponsetohormoneresponsetohypoxiaresponsetoleadionresponsetolipopolysaccharideresponsetonicotineresponsetonitricoxideresponsetonutrientlevelsresponsetoorganiccycliccompoundresponsetoorganonitrogencompoundresponsetopeptidehormoneresponsetovitaminEretrogradetrans-synapticsignalingbynitricoxidestriatedmusclecontractionsynapticsignalingbynitricoxidevasodilationxenobioticcatabolicprocess
Amyloid-beta precursor protein
21
Amyloid-beta precursor protein
21
5.8
47
0.37
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Olfactory receptor 51B2
357
Olfactory receptor 51B2
357
7.7
71
0.18
O51B2O51B2Q9Y5P1Q9Y5P1
Amyloid-beta precursor protein
18
Amyloid-beta precursor protein
18
6.3
68
0.23
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Myosin-7
130
Myosin-7
130
5.3
64
0.29
MYH7MYH7P12883P12883adultheartdevelopmentATPmetabolicprocesscardiacmusclecontractioncardiacmusclehypertrophyinresponsetostressmusclecontractionmusclefilamentslidingregulationofheartrateregulationofslow-twitchskeletalmusclefibercontractionregulationoftheforceofheartcontractionregulationoftheforceofskeletalmusclecontractionsarcomereorganizationskeletalmusclecontractionstriatedmusclecontractiontransitionbetweenfastandslowfiberventricularcardiacmuscletissuemorphogenesis
Gamma-aminobutyric acid receptor subunit alpha-3
377
Gamma-aminobutyric acid receptor subunit alpha-3
377
5.1
nan
nan
GBRA3GBRA3P20236P20236chemicalsynaptictransmissionchloridetransmembranetransportgamma-aminobutyricacidsignalingpathwayiontransmembranetransportnervoussystemprocessregulationofmembranepotentialregulationofpostsynapticmembranepotentialsignaltransductionsynaptictransmissionGABAergic
Immunoglobulin heavy constant gamma 1
349
Immunoglobulin heavy constant gamma 1
112
3.7
63
0.42
IGHG1IGHG1P01857P01857adaptiveimmuneresponseantibody-dependentcellularcytotoxicityBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Glutamate receptor 3
312
Glutamate receptor 3
334
9.4
nan
nan
GRIA3GRIA3P19492P19492regulationofreceptorrecyclingresponsetofungicideresponsetolithiumion
Nitric oxide synthase, brain
331
Nitric oxide synthase, brain
96
3.5
71
0.41
NOS1NOS1P29476P29476agingargininecatabolicprocessbehavioralresponsetococainebraindevelopmentcellularresponsetoepinephrinestimuluscellularresponsetogrowthfactorstimuluscellularresponsetomechanicalstimulusestablishmentofproteinlocalizationfemalepregnancymulticellularorganismalresponsetostressmusclecontractionnegativeregulationofapoptoticprocessnegativeregulationofbloodpressurenegativeregulationofcalciumiontransportnegativeregulationofcellpopulationproliferationnegativeregulationofcytosoliccalciumionconcentrationnegativeregulationofheartcontractionnegativeregulationofhepaticstellatecellcontractionnegativeregulationofhydrolaseactivitynegativeregulationofinsulinsecretionnegativeregulationofironiontransmembranetransportnegativeregulationofneuronapoptoticprocessnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofpotassiumiontransportnegativeregulationofserotoninuptakenegativeregulationofvasoconstrictionnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionpeptidyl-cysteineS-nitrosylationpositiveregulationofadenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocesspositiveregulationofguanylatecyclaseactivitypositiveregulationofhistoneacetylationpositiveregulationoflong-termsynapticpotentiationpositiveregulationofneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsodiumiontransmembranetransportpositiveregulationoftheforceofheartcontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofheartcontractionregulationofneurogenesisregulationofsensoryperceptionofpainregulationofsodiumiontransportresponsetoactivityresponsetoestrogenresponsetoethanolresponsetoheatresponsetohormoneresponsetohypoxiaresponsetoleadionresponsetolipopolysaccharideresponsetonicotineresponsetonitricoxideresponsetonutrientlevelsresponsetoorganiccycliccompoundresponsetoorganonitrogencompoundresponsetopeptidehormoneresponsetovitaminEretrogradetrans-synapticsignalingbynitricoxidestriatedmusclecontractionsynapticsignalingbynitricoxidevasodilationxenobioticcatabolicprocess
Ribosomal oxygenase 1
300
60S ribosomal protein L8
214
4.1
55
0.44
RIOX1RL8Q9H6W3P62917chromatinorganizationhistoneH3-K36demethylationhistoneH3-K4demethylationnegativeregulationofosteoblastdifferentiationnegativeregulationoftranscriptionDNA-templatedcytoplasmictranslationtranslation
Cytosolic acyl coenzyme A thioester hydrolase
61
Cytosolic acyl coenzyme A thioester hydrolase
61
3.9
76
0.34
BACHBACHQ91V12Q91V12acyl-CoAmetabolicprocesscoenzymeAbiosyntheticprocessfattyacidcatabolicprocessfattyacidmetabolicprocesslong-chainfatty-acyl-CoAcatabolicprocessmedium-chainfattyacidbiosyntheticprocessmedium-chainfatty-acyl-CoAcatabolicprocesspalmiticacidbiosyntheticprocess
Nucleotide exchange factor SIL1
357
Nucleotide exchange factor SIL1
357
7.8
72
0.18
SIL1SIL1Q9H173Q9H173cotranslationalproteintargetingtomembraneintracellularproteintransportproteinfolding
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
267
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
610
4.1
58
0.42
PDE4BPDE4BQ07343Q07343cAMPcatabolicprocesscellularresponsetoepinephrinestimuluscellularresponsetolipopolysaccharidecellularresponsetoxenobioticstimulusleukocytemigrationnegativeregulationofadenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocessnegativeregulationofrelaxationofcardiacmuscleneutrophilchemotaxisneutrophilhomeostasispositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-2productionregulationofcardiacmusclecellcontractionregulationofhighvoltage-gatedcalciumchannelactivitysignaltransductionTcellreceptorsignalingpathway
Ribonuclease pancreatic
32
Ribonuclease pancreatic
32
7.0
57
0.25
RNAS1RNAS1P07998P07998defenseresponsetoGram-positivebacteriumRNAphosphodiesterbondhydrolysis
Cyclin-dependent kinase 5 activator 1
357
Cyclin-dependent kinase 5 activator 1
357
7.9
72
0.18
CD5R1CD5R1Q15078Q15078axonguidanceaxonalfasciculationbraindevelopmentcerebellumdevelopmentembryodevelopmentendinginbirthoregghatchingephrinreceptorsignalingpathwayGprotein-coupledacetylcholinereceptorsignalingpathwayG1toG0transitioninvolvedincelldifferentiationhippocampusdevelopmentionotropicglutamatereceptorsignalingpathwaylayerformationincerebralcortexmicrotubulecytoskeletonorganizationnegativeregulationoftranscriptionDNA-templatedneuroncell-celladhesionneurondifferentiationneuronmigrationneuronprojectiondevelopmentpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofmicrotubulepolymerizationpositiveregulationofneuronapoptoticprocesspositiveregulationofproteintargetingtomembranepositiveregulationofsignalingreceptoractivityregulationofactincytoskeletonorganizationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofdendriticspinemorphogenesisregulationofmacroautophagyregulationofneurondifferentiationregulationofsynapticvesiclecyclerhythmicprocessserinephosphorylationofSTATproteinsuperiorolivarynucleusmaturation
Myosin-7
130
Myosin-7
128
9.6
60
0.17
MYH7MYH7P12883P12883adultheartdevelopmentATPmetabolicprocesscardiacmusclecontractioncardiacmusclehypertrophyinresponsetostressmusclecontractionmusclefilamentslidingregulationofheartrateregulationofslow-twitchskeletalmusclefibercontractionregulationoftheforceofheartcontractionregulationoftheforceofskeletalmusclecontractionsarcomereorganizationskeletalmusclecontractionstriatedmusclecontractiontransitionbetweenfastandslowfiberventricularcardiacmuscletissuemorphogenesis
Caspase-3
220
Caspase-3
220
5.7
82
0.21
CASP3CASP3P42574P42574anteriorneuraltubeclosureapoptoticprocessapoptoticsignalingpathwayaxonalfasciculationBcellhomeostasiscellfatecommitmentcellularresponsetoDNAdamagestimuluscellularresponsetostaurosporineepithelialcellapoptoticprocesserythrocytedifferentiationexecutionphaseofapoptosisfibroblastapoptoticprocessglialcellapoptoticprocessheartdevelopmenthippocampusdevelopmentintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoosmoticstresskeratinocytedifferentiationlearningormemoryleukocyteapoptoticprocessluteolysisnegativeregulationofactivatedTcellproliferationnegativeregulationofapoptoticprocessnegativeregulationofBcellproliferationneuronapoptoticprocessneurondifferentiationneurotrophinTRKreceptorsignalingpathwayplateletformationpositiveregulationofamyloid-betaformationpositiveregulationofapoptoticDNAfragmentationpositiveregulationofapoptoticprocesspositiveregulationofneuronapoptoticprocessproteincatabolicprocessproteinprocessingproteolysisregulationofmacroautophagyregulationofproteinstabilityresponsetoaminoacidresponsetoantibioticresponsetocobaltionresponsetoestradiolresponsetoglucocorticoidresponsetoglucoseresponsetohydrogenperoxideresponsetohypoxiaresponsetolipopolysaccharideresponsetonicotineresponsetotumornecrosisfactorresponsetoUVresponsetoX-rayresponsetoxenobioticstimulussensoryperceptionofsoundstriatedmusclecelldifferentiationTcellhomeostasiswoundhealing
Transcriptional regulator ATRX
1614
Transcriptional regulator ATRX
1614
4.3
nan
nan
ATRXATRXP46100P46100cellularresponsetohydroxyureachromatinremodelingchromosomeorganizationinvolvedinmeioticcellcycleDNAdamageresponsesignaltransductionbyp53classmediatorDNAmethylationDNArepairDNAreplication-independentchromatinassemblyforebraindevelopmentmeioticspindleorganizationmulticellularorganismgrowthnegativeregulationofmaintenanceofmitoticsisterchromatidcohesiontelomericnegativeregulationoftelomericRNAtranscriptionfromRNApolIIpromoternucleosomeassemblypositiveregulationofnuclearcellcycleDNAreplicationpositiveregulationoftelomeremaintenancepositiveregulationoftelomericRNAtranscriptionfromRNApolIIpromoterpositiveregulationoftranscriptionbyRNApolymeraseIIpost-embryonicforelimbmorphogenesisproteinlocalizationtochromosometelomericregionregulationofhistoneH3-K9trimethylationregulationoftranscriptionDNA-templatedreplicationforkprocessingseminiferoustubuledevelopmentSertolicelldevelopmentspermatogenesistranscriptionbyRNApolymeraseII
Inhibitor of nuclear factor kappa-B kinase subunit alpha
114
Inhibitor of nuclear factor kappa-B kinase subunit alpha
114
9.2
71
0.15
IKKAIKKAO15111O15111anatomicalstructuremorphogenesiscellularresponsetocadmiumioncellularresponsetoreactiveoxygenspeciescellularresponsetotumornecrosisfactorcellularresponsetovirusI-kappaBkinase/NF-kappaBsignalingI-kappaBphosphorylationimmuneresponseinflammatoryresponseinnateimmuneresponsenegativeregulationofNF-kappaBtranscriptionfactoractivityNIK/NF-kappaBsignalingpeptidyl-serinephosphorylationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterferon-alphaproductionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedproteinphosphorylationresponsetovirustumornecrosisfactor-mediatedsignalingpathway
Integrin alpha-X
920
Integrin beta-2
695
9.0
57
0.2
ITAXITB2P20702P05107animalorganmorphogenesiscelladhesioncelladhesionmediatedbyintegrincell-celladhesioncell-matrixadhesiondefenseresponsetovirusheterotypiccell-celladhesionintegrin-mediatedsignalingpathwaypositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialtubemorphogenesispositiveregulationofgeneexpressionpositiveregulationofmyelinationamyloid-betaclearanceapoptoticprocesscellmigrationcell-celladhesionviaplasma-membraneadhesionmoleculescell-cellsignalingcellularresponsetolow-densitylipoproteinparticlestimulusendodermalcelldifferentiationinflammatoryresponseleukocytecell-celladhesionmicroglialcellactivationnegativeregulationofdopaminemetabolicprocessneutrophilchemotaxisneutrophilmigrationphagocytosisengulfmentpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofneurondeathpositiveregulationofneutrophildegranulationpositiveregulationofprostaglandin-Esynthaseactivitypositiveregulationofproteintargetingtomembranepositiveregulationofsuperoxideaniongenerationreceptorclusteringreceptorinternalizationreceptor-mediatedendocytosisregulationofcellshaperegulationofpeptidyl-tyrosinephosphorylation
CCAAT/enhancer-binding protein alpha
245
CCAAT/enhancer-binding protein alpha
56
7.5
56
0.24
CEBPACEBPAP49715P49715brownfatcelldifferentiationcellularresponsetolithiumioncellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcholesterolmetabolicprocesscytokine-mediatedsignalingpathwayembryonicplacentadevelopmentepithelialcellmaturationfatcelldifferentiationgenerationofprecursormetabolitesandenergyglucosehomeostasisgranulocytedifferentiationhematopoieticstemcellproliferationinnereardevelopmentintegratedstressresponsesignalinginterleukin-6-mediatedsignalingpathwaylipidhomeostasisliverdevelopmentlungdevelopmentmacrophagedifferentiationmitochondrionorganizationmyeloidcelldifferentiationnegativeregulationofcellpopulationproliferationnegativeregulationofcyclin-dependentproteinserine/threoninekinaseactivitynegativeregulationofhematopoieticstemcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedNotchsignalingpathwaypositiveregulationofDNA-templatedtranscriptioninitiationpositiveregulationoffatcelldifferentiationpositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationofmacrophageactivationpositiveregulationofosteoblastdifferentiationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedtranscriptionbyRNApolymeraseIureacyclewhitefatcelldifferentiation
Cytochrome c oxidase assembly factor 6 homolog
59
Cytochrome c oxidase assembly factor 6 homolog
58
6.8
65
0.23
COA6COA6Q5JTJ3Q5JTJ3mitochondrialATPsynthesiscoupledelectrontransportplasmamembraneATPsynthesiscoupledelectrontransportrespiratorychaincomplexIVassembly
Integrin alpha-IIb
959
Integrin beta-3
713
9.4
nan
nan
ITA2BITB3Q17R67P05106angiogenesiscelladhesionmediatedbyintegrincell-celladhesioncell-matrixadhesionintegrin-mediatedsignalingpathwayactivationofproteinkinaseactivityangiogenesisinvolvedinwoundhealingapolipoproteinA-I-mediatedsignalingpathwayapoptoticcellclearancebloodcoagulationcelladhesioncellmigrationcell-substrateadhesioncell-substratejunctionassemblycellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetomechanicalstimuluscellularresponsetoplatelet-derivedgrowthfactorstimuluscellularresponsetoxenobioticstimulusembryoimplantationheterotypiccell-celladhesionmesodermalcelldifferentiationnegativechemotaxisnegativeregulationofcelldeathnegativeregulationoflipidstoragenegativeregulationoflipidtransportnegativeregulationoflipoproteinmetabolicprocessnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofmacrophagederivedfoamcelldifferentiationplateletactivationplateletaggregationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofadenylatecyclase-inhibitingopioidreceptorsignalingpathwaypositiveregulationofangiogenesispositiveregulationofboneresorptionpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofosteoblastproliferationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofTcellmigrationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofactincytoskeletonorganizationregulationofboneresorptionregulationofextracellularmatrixorganizationregulationofpostsynapticneurotransmitterreceptorinternalizationregulationofproteinlocalizationregulationofproteintyrosinekinaseactivityregulationofreleaseofsequesteredcalciumionintocytosolregulationofserotoninuptakeregulationoftrophoblastcellmigrationresponsetoactivityresponsetoradiationsmoothmusclecellmigrationsubstrateadhesion-dependentcellspreadingtubedevelopmentviralentryintohostcellwoundhealing
Collagen alpha-1(III) chain
1196
Collagen alpha-1(III) chain
1196
7.5
nan
nan
CO3A1CO3A1P02461P02461aortasmoothmuscletissuemorphogenesisbasementmembraneorganizationcell-matrixadhesioncellularresponsetoaminoacidstimuluscerebralcortexdevelopmentchondrocytedifferentiationcollagenfibrilorganizationdigestivetractdevelopmentelasticfiberassemblyendochondralbonemorphogenesisextracellularmatrixorganizationfibroblastproliferationheartdevelopmentinuteroembryonicdevelopmentintegrin-mediatedsignalingpathwaylayerformationincerebralcortexlimbjointmorphogenesislungdevelopmentmulticellularorganismgrowthnegativeregulationofimmuneresponsenegativeregulationofneuronmigrationneuronmigrationpeptidecross-linkingplateletactivationpositiveregulationofRhoproteinsignaltransductionresponsetoangiotensinresponsetocytokineresponsetoradiationskindevelopmentsupramolecularfiberorganizationtissuehomeostasistransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbeta1productionwoundhealing
Insulin
6
Insulin
31
8.6
nan
nan
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
Uncharacterized protein DKFZp686I04196
100
Tumor necrosis factor receptor superfamily member 13C
24
5.4
58
0.32
Q6N093TR13CQ6N093Q96RJ3adaptiveimmuneresponseBcellcostimulationpositiveregulationofBcellproliferationpositiveregulationofTcellproliferationTcellcostimulationtumornecrosisfactor-mediatedsignalingpathway
Uncharacterized protein DKFZp686I04196
97
Tumor necrosis factor receptor superfamily member 13C
24
5.3
76
0.25
Q6N093TR13CQ6N093Q96RJ3adaptiveimmuneresponseBcellcostimulationpositiveregulationofBcellproliferationpositiveregulationofTcellproliferationTcellcostimulationtumornecrosisfactor-mediatedsignalingpathway
Kinesin-like protein KIF21A
1421
Kinesin-like protein KIF21A
1421
9.6
71
0.15
KI21AKI21AQ7Z4S6Q7Z4S6microtubule-basedmovement
Transcriptional regulator ATRX
200
Transcriptional regulator ATRX
232
4.7
nan
nan
ATRXATRXP46100P46100cellularresponsetohydroxyureachromatinremodelingchromosomeorganizationinvolvedinmeioticcellcycleDNAdamageresponsesignaltransductionbyp53classmediatorDNAmethylationDNArepairDNAreplication-independentchromatinassemblyforebraindevelopmentmeioticspindleorganizationmulticellularorganismgrowthnegativeregulationofmaintenanceofmitoticsisterchromatidcohesiontelomericnegativeregulationoftelomericRNAtranscriptionfromRNApolIIpromoternucleosomeassemblypositiveregulationofnuclearcellcycleDNAreplicationpositiveregulationoftelomeremaintenancepositiveregulationoftelomericRNAtranscriptionfromRNApolIIpromoterpositiveregulationoftranscriptionbyRNApolymeraseIIpost-embryonicforelimbmorphogenesisproteinlocalizationtochromosometelomericregionregulationofhistoneH3-K9trimethylationregulationoftranscriptionDNA-templatedreplicationforkprocessingseminiferoustubuledevelopmentSertolicelldevelopmentspermatogenesistranscriptionbyRNApolymeraseII
T-cell receptor alpha chain V region PHDS58
213
T-cell receptor beta-1 chain C region
127
6.3
nan
nan
TVA1TCB1P01738P01852adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Macrophage migration inhibitory factor
99
Macrophage migration inhibitory factor
99
8.1
73
0.17
MIFMIFP14174P14174carboxylicacidmetabolicprocesscellsurfacereceptorsignalingpathwaycellularsenescenceDNAdamageresponsesignaltransductionbyp53classmediatorinflammatoryresponseinnateimmuneresponsenegativeregulationofapoptoticprocessnegativeregulationofcellmigrationnegativeregulationofcellularsenescencenegativeregulationofDNAdamageresponsesignaltransductionbyp53classmediatornegativeregulationofgeneexpressionnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatornegativeregulationofmacrophagechemotaxisnegativeregulationofmatureBcellapoptoticprocessnegativeregulationofmyeloidcellapoptoticprocessnegativeregulationofproteinmetabolicprocesspositiveregulationofarachidonicacidsecretionpositiveregulationofBcellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofchemokine(C-X-Cmotif)ligand2productionpositiveregulationofcytokineproductionpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofMAPkinaseactivitypositiveregulationofmyeloidleukocytecytokineproductioninvolvedinimmuneresponsepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphorylationpositiveregulationofprostaglandinsecretioninvolvedinimmuneresponsepositiveregulationofproteinkinaseAsignalingpositiveregulationoftumornecrosisfactorproductionprostaglandinbiosyntheticprocessproteinhomotrimerizationregulationofmacrophageactivation
Retinol-binding protein 2
36
Retinol-binding protein 2
36
7.2
61
0.23
RET2RET2P50120P50120epidermisdevelopmentfattyacidtransportvitaminAmetabolicprocess
Isoform A of Ketohexokinase
98
Isoform A of Ketohexokinase
99
9.4
89
0.12
KHKKHKP50053-2P50053-2
Kinetochore protein Spc25
137
Kinetochore protein Spc24
111
7.9
54
0.24
SPC25SPC24Q9HBM1Q8NBT2attachmentofspindlemicrotubulestokinetochorecelldivisionchromosomesegregationmitoticspindleassemblycheckpointsignalingmitoticspindleorganization
Retinol-binding protein 2
32
Retinol-binding protein 2
28
8.1
67
0.19
RET2RET2P50120P50120epidermisdevelopmentfattyacidtransportvitaminAmetabolicprocess
LIM domain-binding protein 1
48
LIM domain-binding protein 1
48
7.9
63
0.2
LDB1LDB1P70662P70662anterior/posterioraxisspecificationcelladhesioncelldifferentiationcellularcomponentassemblycerebellarPurkinjecelldifferentiationcerebellumdevelopmentepithelialstructuremaintenancegastrulationwithmouthformingsecondhairfollicledevelopmentheaddevelopmenthistoneH3-K4acetylationmesendodermdevelopmentnegativeregulationoferythrocytedifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednervoussystemdevelopmentneurondifferentiationpositiveregulationofcelladhesionpositiveregulationofhemoglobinbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprimitiveerythrocytedifferentiationregulationofcellmigrationregulationoffocaladhesionassemblyregulationofkinaseactivityregulationoftranscriptionelongationfromRNApolymeraseIIpromotersomaticstemcellpopulationmaintenancetranscriptionbyRNApolymeraseIItranscription-dependenttetheringofRNApolymeraseIIgeneDNAatnuclearperipheryWntsignalingpathway
Isoform A of Ketohexokinase
98
Isoform A of Ketohexokinase
98
4.0
91
0.27
KHKKHKP50053-2P50053-2
Amyloid-beta precursor protein
8
Amyloid-beta precursor protein
8
7.4
59
0.23
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Polyubiquitin-B
48
Polyubiquitin-B
48
3.9
67
0.39
UBBUBBP0CG47P0CG47energyhomeostasisfatpaddevelopmentfemalegonaddevelopmentfemalemeiosisIhypothalamusgonadotrophin-releasinghormoneneurondevelopmentmalemeiosisImitochondriontransportalongmicrotubulemodification-dependentproteincatabolicprocessneuronprojectionmorphogenesispositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofproteinmonoubiquitinationpositiveregulationofproteinubiquitinationproteinubiquitinationregulationofmitochondrialmembranepotentialregulationofneurondeathregulationofproteasomalproteincatabolicprocessseminiferoustubuledevelopment
Myc proto-oncogene protein
438
Protein max
nan
3.0
nan
nan
MYCMAXP01106P61244branchinginvolvedinuretericbudmorphogenesiscellularironionhomeostasiscellularresponsetoDNAdamagestimuluscellularresponsetohypoxiacellularresponsetoUVcellularresponsetoxenobioticstimuluschromatinremodelingchromosomeorganizationenergyreservemetabolicprocessERK1andERK2cascadefibroblastapoptoticprocessG1/StransitionofmitoticcellcycleMAPKcascadenegativeregulationofapoptoticprocessnegativeregulationofcelldivisionnegativeregulationoffibroblastproliferationnegativeregulationofmonocytedifferentiationnegativeregulationofstress-activatedMAPKcascadenegativeregulationoftranscriptionbyRNApolymeraseIIoxygentransportpositiveregulationofcellpopulationproliferationpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofDNAbiosyntheticprocesspositiveregulationofDNAmethylationpositiveregulationofepithelialcellproliferationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofmesenchymalcellproliferationpositiveregulationofmetanephriccapmesenchymalcellproliferationpositiveregulationofmiRNAtranscriptionpositiveregulationofresponsetoDNAdamagestimuluspositiveregulationoftelomeraseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprotein-DNAcomplexdisassemblyregulationofcellcycleprocessregulationofgeneexpressionregulationofsomaticstemcellpopulationmaintenanceregulationoftelomeremaintenanceregulationoftranscriptionbyRNApolymeraseIIresponsetogammaradiationresponsetogrowthfactorresponsetoxenobioticstimuluscellularresponsetopeptidehormonestimuluscellularresponsetostarvationnegativeregulationofgeneexpressionneuronapoptoticprocessprotein-containingcomplexassemblyresponsetoaxoninjuryresponsetoinsulinretinadevelopmentincamera-typeeye
Kinetochore protein Spc25
232
Kinetochore protein Spc24
134
4.5
64
0.34
SPC25SPC24Q9HBM1Q8NBT2attachmentofspindlemicrotubulestokinetochorecelldivisionchromosomesegregationmitoticspindleassemblycheckpointsignalingmitoticspindleorganization
Retinol-binding protein 2
32
Retinol-binding protein 2
32
3.8
67
0.4
RET2RET2P50120P50120epidermisdevelopmentfattyacidtransportvitaminAmetabolicprocess
GTPase KRas
70
GTPase KRas
70
6.6
61
0.25
RASKRASKP01116P01116actincytoskeletonorganizationendocrinesignalingepithelialtubebranchinginvolvedinlungmorphogenesisforebrainastrocytedevelopmentglialcellproliferationhomeostasisofnumberofcellswithinatissueMAPKcascadenegativeregulationofepithelialcelldifferentiationnegativeregulationofneuronapoptoticprocessneuronapoptoticprocesspositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofglialcellproliferationpositiveregulationofproteinphosphorylationpositiveregulationofRacproteinsignaltransductionRacproteinsignaltransductionRasproteinsignaltransductionregulationoflong-termneuronalsynapticplasticityregulationofproteinstabilityregulationofsynaptictransmissionGABAergicskeletalmusclecelldifferentiationstriatedmusclecelldifferentiationtypeIpneumocytedifferentiationvisuallearning
Glutathione S-transferase A1
101
Glutathione S-transferase A1
101
5.8
44
0.39
GSTA1GSTA1P08263P08263epithelialcelldifferentiationglutathionederivativebiosyntheticprocessglutathionemetabolicprocesslinoleicacidmetabolicprocessprostaglandinmetabolicprocessxenobioticmetabolicprocess
Microtubule-associated protein RP/EB family member 1
1411
Microtubule-associated protein RP/EB family member 1
1411
5.0
57
0.35
MARE1MARE1Q15691Q15691attachmentofmitoticspindlemicrotubulestokinetochorecelldivisioncellmigrationestablishmentofmitoticspindleorientationmicrotubulebundleformationmicrotubulepolymerizationnegativeregulationofmicrotubulepolymerizationnon-motileciliumassemblypositiveregulationofmicrotubuleplus-endbindingpositiveregulationofmicrotubulepolymerizationproteinlocalizationproteinlocalizationtoastralmicrotubuleproteinlocalizationtocentrosomeproteinlocalizationtomicrotubuleproteinlocalizationtomicrotubuleplus-endregulationofmicrotubulepolymerizationordepolymerizationspindleassembly
Cystatin-C
47
Cystatin-C
47
7.9
87
0.14
CYTCCYTCP01034P01034defenseresponsenegativeregulationofbloodvesselremodelingnegativeregulationofcollagencatabolicprocessnegativeregulationofcysteine-typeendopeptidaseactivitynegativeregulationofelastincatabolicprocessnegativeregulationofextracellularmatrixdisassemblynegativeregulationofpeptidaseactivitynegativeregulationofproteolysisregulationoftissueremodelingsupramolecularfiberorganization
Phospholipase A and acyltransferase 3
67
Phospholipase A and acyltransferase 3
67
5.0
73
0.27
PLAT3PLAT3P53816P53816etherlipidmetabolicprocesslensfibercelldifferentiationlipidcatabolicprocessmembranedisassemblyN-acylphosphatidylethanolaminemetabolicprocessorganelledisassemblyperoxisomeorganizationphosphatidylethanolamineacyl-chainremodelingphospholipidbiosyntheticprocessphospholipidmetabolicprocessregulationofadiposetissuedevelopmentresponsetobacteriumtriglyceridemetabolicprocess
Ubiquitin-conjugating enzyme E2 K
124
Polyubiquitin-B
48
8.3
45
0.27
UBE2KUBBP61086P0CG47cellularresponsetointerferon-betafreeubiquitinchainpolymerizationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationoftumornecrosisfactor-mediatedsignalingpathwaypositiveregulationoftypeIinterferon-mediatedsignalingpathwayproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinK48-linkedubiquitinationproteinpolyubiquitinationregulationofproteasomalubiquitin-dependentproteincatabolicprocessubiquitin-dependentproteincatabolicprocessenergyhomeostasisfatpaddevelopmentfemalegonaddevelopmentfemalemeiosisIhypothalamusgonadotrophin-releasinghormoneneurondevelopmentmalemeiosisImitochondriontransportalongmicrotubulemodification-dependentproteincatabolicprocessneuronprojectionmorphogenesispositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofproteinmonoubiquitinationpositiveregulationofproteinubiquitinationproteinubiquitinationregulationofmitochondrialmembranepotentialregulationofneurondeathregulationofproteasomalproteincatabolicprocessseminiferoustubuledevelopment
Ribonuclease pancreatic
31
Ribonuclease pancreatic
31
7.0
70
0.2
RNAS1RNAS1P07998P07998defenseresponsetoGram-positivebacteriumRNAphosphodiesterbondhydrolysis
Amyloid-beta precursor protein
8
Amyloid-beta precursor protein
18
8.2
62
0.2
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Cystatin-C
47
Cystatin-C
69
8.7
85
0.14
CYTCCYTCP01034P01034defenseresponsenegativeregulationofbloodvesselremodelingnegativeregulationofcollagencatabolicprocessnegativeregulationofcysteine-typeendopeptidaseactivitynegativeregulationofelastincatabolicprocessnegativeregulationofextracellularmatrixdisassemblynegativeregulationofpeptidaseactivitynegativeregulationofproteolysisregulationoftissueremodelingsupramolecularfiberorganization
Retinol-binding protein 2
28
Retinol-binding protein 2
28
4.5
60
0.37
RET2RET2P50120P50120epidermisdevelopmentfattyacidtransportvitaminAmetabolicprocess
Amyloid-beta precursor protein
5
Amyloid-beta precursor protein
5
9.2
34
0.32
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Bis(5'-adenosyl)-triphosphatase
8
Bis(5'-adenosyl)-triphosphatase
8
5.4
50
0.37
FHITFHITP49789P49789diadenosinetriphosphatecatabolicprocessintrinsicapoptoticsignalingpathwaybyp53classmediatornegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocesspurinenucleotidemetabolicprocess
Amyloid-beta precursor protein
5
Amyloid-beta precursor protein
21
7.7
40
0.33
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Resistin-like beta
25
Resistin-like beta
25
3.6
nan
nan
RETNBRETNBQ99P86Q99P86responsetobacterium
CD320 antigen
89
CD320 antigen
89
9.3
nan
nan
CD320CD320Q9NPF0Q9NPF0BcellcostimulationcobalaminmetabolicprocesscobalamintransportpositiveregulationofBcellproliferationregulationofvitaminmetabolicprocess
Major prion protein
179
Major prion protein
214
9.1
55
0.2
PRIOPRIOP04156P04156activationofproteinkinaseactivitycalcium-mediatedsignalingusingintracellularcalciumsourcecellcyclecellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocopperioncellularresponsetoxenobioticstimulusdendriticspinemaintenancelearningormemorylong-termmemorynegativeregulationofactivatedTcellproliferationnegativeregulationofamyloidprecursorproteincatabolicprocessnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofcalcineurin-NFATsignalingcascadenegativeregulationofdendriticspinemaintenancenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofinterferon-gammaproductionnegativeregulationofinterleukin-17productionnegativeregulationofinterleukin-2productionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofproteinphosphorylationnegativeregulationofproteinprocessingnegativeregulationofTcellreceptorsignalingpathwayneuronprojectionmaintenancepositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteintargetingtomembranepositiveregulationofproteintyrosinekinaseactivityproteindestabilizationproteinhomooligomerizationregulationofcalciumionimportacrossplasmamembraneregulationofglutamatereceptorsignalingpathwayregulationofintracellularcalciumactivatedchloridechannelactivityregulationofpeptidyl-tyrosinephosphorylationregulationofpotassiumiontransmembranetransportresponsetoamyloid-betaresponsetocadmiumionresponsetooxidativestress
Insulin
100
Insulin
4
8.0
53
0.24
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
HLA class II histocompatibility antigen, DQ alpha 1 chain
11
HLA class II histocompatibility antigen, DQ beta 1 chain
47
4.6
95
0.23
DQA1DQB1P01907P03992adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIimmuneresponsepeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivationhumoralimmuneresponseTcellreceptorsignalingpathway
Chymotrypsinogen A
1
Chymotrypsinogen A
1
10.0
nan
nan
CTRACTRAP00766P00766digestionproteolysis
Cartilage oligomeric matrix protein
71
Cartilage oligomeric matrix protein
71
6.2
nan
nan
COMPCOMPQ9R0G6Q9R0G6apoptoticprocessarterymorphogenesisbloodcoagulationBMPsignalingpathwaybonegrowthbonemineralizationbonemorphogenesiscartilagedevelopmentcartilagehomeostasischondrocytedevelopmentchondrocyteproliferationcollagenfibrilorganizationendochondralbonegrowthgrowthplatecartilagedevelopmentlimbdevelopmentmulticellularorganismagingmulticellularorganismgrowthmusclecelldevelopmentmusculoskeletalmovementnegativeregulationofapoptoticprocessnegativeregulationofhemostasisneuromuscularprocessossificationplateletaggregationpositiveregulationofchondrocyteproliferationproteinhomooligomerizationproteinprocessingproteinsecretionregulationofbonemineralizationregulationofgeneexpressionresponsetounfoldedproteinskeletalsystemdevelopmentskindevelopmenttendondevelopmentvascularassociatedsmoothmusclecelldevelopmentvascularassociatedsmoothmusclecontraction
Neutrophil defensin 3
66
Neutrophil defensin 3
66
8.4
nan
nan
DEF3DEF3P59666P59666antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetovirusinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingofcellsofanotherorganismmembranedisruptioninanotherorganism
AP-2 complex subunit mu
337
AP-2 complex subunit mu
501
7.0
75
0.19
AP2M1AP2M1P84092P84092clathrin-dependentendocytosisendocytosisintracellularproteintransportnegativeregulationofproteinlocalizationtoplasmamembranepositiveregulationofreceptorinternalizationpositiveregulationofsynapticvesicleendocytosispostsynapticneurotransmitterreceptorinternalizationprotein-containingcomplexassemblyreceptorinternalizationregulationofvesiclesizesynapticvesicleendocytosisvesiclebuddingfrommembranevesicle-mediatedtransport
Uncharacterized protein DKFZp686I04196
100
Tumor necrosis factor receptor superfamily member 13C
35
5.4
54
0.34
Q6N093TR13CQ6N093Q96RJ3adaptiveimmuneresponseBcellcostimulationpositiveregulationofBcellproliferationpositiveregulationofTcellproliferationTcellcostimulationtumornecrosisfactor-mediatedsignalingpathway
Major prion protein
214
Major prion protein
214
7.9
57
0.22
PRIOPRIOP04156P04156activationofproteinkinaseactivitycalcium-mediatedsignalingusingintracellularcalciumsourcecellcyclecellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocopperioncellularresponsetoxenobioticstimulusdendriticspinemaintenancelearningormemorylong-termmemorynegativeregulationofactivatedTcellproliferationnegativeregulationofamyloidprecursorproteincatabolicprocessnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofcalcineurin-NFATsignalingcascadenegativeregulationofdendriticspinemaintenancenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofinterferon-gammaproductionnegativeregulationofinterleukin-17productionnegativeregulationofinterleukin-2productionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofproteinphosphorylationnegativeregulationofproteinprocessingnegativeregulationofTcellreceptorsignalingpathwayneuronprojectionmaintenancepositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteintargetingtomembranepositiveregulationofproteintyrosinekinaseactivityproteindestabilizationproteinhomooligomerizationregulationofcalciumionimportacrossplasmamembraneregulationofglutamatereceptorsignalingpathwayregulationofintracellularcalciumactivatedchloridechannelactivityregulationofpeptidyl-tyrosinephosphorylationregulationofpotassiumiontransmembranetransportresponsetoamyloid-betaresponsetocadmiumionresponsetooxidativestress
Egl nine homolog 1
283
Hypoxia-inducible factor 1-alpha
412
9.3
55
0.19
EGLN1HIF1AQ9GZT9Q16665cardiacmuscletissuemorphogenesiscellularironionhomeostasiscellularresponsetohypoxiahearttrabeculaformationlabyrinthinelayerdevelopmentnegativeregulationofcyclic-nucleotidephosphodiesteraseactivitynegativeregulationofDNA-bindingtranscriptionfactoractivityoxygenhomeostasispeptidyl-prolinehydroxylationto4-hydroxy-L-prolinepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofangiogenesisregulationofneurondeathregulationofpostsynapseorganizationregulationofproteincatabolicprocessatpostsynapsemodulatingsynaptictransmissionresponsetohypoxiaresponsetonitricoxideventricularseptummorphogenesisangiogenesisaxonaltransportofmitochondrionB-1Bcellhomeostasisbonemineralizationcardiacventriclemorphogenesiscellularglucosehomeostasiscellularresponsetointerleukin-1cellularresponsetoviruscerebralcortexdevelopmentchondrocytedifferentiationcollagenmetabolicprocessconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingdigestivetractmorphogenesisdopaminergicneurondifferentiationelastinmetabolicprocessembryonichemopoiesisembryonicplacentadevelopmentepithelialcelldifferentiationinvolvedinmammaryglandalveolusdevelopmentepithelialtomesenchymaltransitionglandularepithelialcellmaturationheartloopinghemoglobinbiosyntheticprocesshypoxia-induciblefactor-1alphasignalingpathwayinsulinsecretioninvolvedincellularresponsetoglucosestimulusintestinalepithelialcellmaturationirismorphogenesislactatemetabolicprocesslactationmesenchymalcellapoptoticprocessmusclecellcellularhomeostasisnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofgrowthnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofthymocyteapoptoticprocessnegativeregulationofTORsignalingneuralcrestcellmigrationneuralfoldelevationformationneuroblastproliferationneuronapoptoticprocessoutflowtractmorphogenesispositiveregulationofangiogenesispositiveregulationofautophagyofmitochondrionpositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofchemokineproductionpositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellmigrationpositiveregulationoferythrocytedifferentiationpositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhormonebiosyntheticprocesspositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofmacroautophagypositiveregulationofmiRNAtranscriptionpositiveregulationofneuroblastproliferationpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofsignalingreceptoractivitypositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofaerobicrespirationregulationofgeneexpressionregulationofglycolyticprocessregulationofproteinneddylationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetooxidativestressregulationoftranscriptionDNA-templatedregulationoftransforminggrowthfactorbeta2productionresponsetoironionresponsetomuscleactivityresponsetoreactiveoxygenspeciesretinavasculaturedevelopmentincamera-typeeyesignaltransductionTORsignalingvascularendothelialgrowthfactorproductionvisuallearning
BTB/POZ domain-containing protein KCTD12
300
BTB/POZ domain-containing protein KCTD12
300
5.6
nan
nan
KCD12KCD12Q96CX2Q96CX2proteinhomooligomerization
Transforming growth factor beta-1 proprotein
225
Transforming growth factor beta-1 proprotein
225
8.3
nan
nan
TGFB1TGFB1P01137P01137aorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaycellmigrationcell-celljunctionorganizationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluschondrocytedifferentiationcommon-partnerSMADproteinphosphorylationconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingembryonicliverdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayheartdevelopmentheartvalvemorphogenesishematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphnodedevelopmentmacrophagederivedfoamcelldifferentiationMAPKcascademembraneproteinintracellulardomainproteolysisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofcytolysisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixdisassemblynegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofmacrophagecytokineproductionnegativeregulationofmiRNAmaturationnegativeregulationofmiRNAtranscriptionnegativeregulationofmiRNA-mediatedgenesilencingnegativeregulationofmyoblastdifferentiationnegativeregulationofproteinlocalizationtoplasmamembranenegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationoftranscriptionDNA-templatedneuraltubeclosureneuraltubedevelopmentossificationinvolvedinboneremodelingpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixassemblypositiveregulationoffibroblastmigrationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationofSMADproteinsignaltransductionpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularpermeabilityproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofbindingregulationofbloodvesselremodelingregulationofcellmigrationregulationofcellpopulationproliferationregulationofDNAbindingregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
PRSS3 protein
200
Amyloid-beta A4 protein
17
10.0
103
0.1
Q8N2U3H7C0V9Q8N2U3H7C0V9proteolysisnervoussystemdevelopment
Cardiac phospholamban
36
Cardiac phospholamban
30
4.0
55
0.46
PPLAPPLAP61012P61012adenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocesscardiacmuscletissuedevelopmentcellularcalciumionhomeostasismusclecellcellularhomeostasisnegativeregulationofATP-dependentactivitynegativeregulationofATPase-coupledcalciumtransmembranetransporteractivitynegativeregulationofcalciumionbindingnegativeregulationofcalciumionimportintosarcoplasmicreticulumnegativeregulationofcalciumiontransmembranetransporteractivitynegativeregulationofheartrateNotchsignalingpathwayregulationofcalciumionimportregulationofcalciumiontransportregulationofcardiacmusclecellcontractionregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofrelaxationofmuscleregulationofryanodine-sensitivecalcium-releasechannelactivityregulationoftheforceofheartcontractionbycardiacconduction
PRSS3 protein
200
Amyloid-beta A4 protein
34
8.4
100
0.12
Q8N2U3H7C0V9Q8N2U3H7C0V9proteolysisnervoussystemdevelopment
Uncharacterized protein DKFZp686I04196
97
Tumor necrosis factor receptor superfamily member 13C
35
4.6
72
0.3
Q6N093TR13CQ6N093Q96RJ3adaptiveimmuneresponseBcellcostimulationpositiveregulationofBcellproliferationpositiveregulationofTcellproliferationTcellcostimulationtumornecrosisfactor-mediatedsignalingpathway
Insulin
109
Insulin
22
6.1
49
0.34
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
Complement C3
1010
Complement C3
1010
8.1
nan
nan
CO3CO3P01026P01026amyloid-betaclearancebloodcoagulationcellsurfacereceptorsignalingpathwayinvolvedincell-cellsignalingchemotaxiscomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitycomplement-mediatedsynapsepruningfattyacidmetabolicprocessinflammatoryresponseneuronremodelingopsonizationoviductepitheliumdevelopmentpositiveregulationofactivationofmembraneattackcomplexpositiveregulationofangiogenesispositiveregulationofapoptoticcellclearancepositiveregulationofdevelopmentalgrowthpositiveregulationofERK1andERK2cascadepositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofglucosetransmembranetransportpositiveregulationoflipidstoragepositiveregulationofopsonizationpositiveregulationofphagocytosispositiveregulationofphagocytosisengulfmentpositiveregulationofproteinphosphorylationpositiveregulationofreceptor-mediatedendocytosispositiveregulationoftypeIIahypersensitivitypositiveregulationofvascularendothelialgrowthfactorproductionproteolysisregulationofcomplementactivationregulationofcomplementactivationalternativepathwayregulationoftriglyceridebiosyntheticprocessresponsetobacteriumresponsetoestradiolresponsetoestrogenresponsetoglucocorticoidresponsetomagnesiumionresponsetopaclitaxelresponsetoprogesteroneretinadevelopmentincamera-typeeyetoleranceinductionvascularassociatedsmoothmusclecelldifferentiationvertebrateeye-specificpatterning
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
89
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
89
8.7
nan
nan
CTDS2CTDS2O14595O14595negativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofproteinphosphorylationproteindephosphorylation
T-cell surface glycoprotein CD3 epsilon chain
119
T-cell surface glycoprotein CD3 delta chain
93
3.3
nan
nan
CD3ECD3DP07766P04234adaptiveimmuneresponsealpha-betaTcellactivationapoptoticsignalingpathwaycalcium-mediatedsignalingCD4-positivealpha-betaTcellproliferationcellsurfacereceptorsignalingpathwaycerebellumdevelopmentdendritedevelopmentGprotein-coupledreceptorsignalingpathwaygamma-deltaTcellactivationnegativeregulationofgeneexpressionnegativeregulationofsmoothenedsignalingpathwaynegativethymicTcellselectionpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofgeneexpressionpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofTcellanergypositiveregulationofTcellproliferationpositivethymicTcellselectionprotein-containingcomplexassemblyregulationofapoptoticprocesssignalcomplexassemblysmoothenedsignalingpathwayTcellactivationTcellanergyTcellcostimulationTcellreceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathway
Nitric oxide synthase, brain
302
Nitric oxide synthase, brain
302
4.5
nan
nan
NOS1NOS1P29475P29475argininecatabolicprocesscellredoxhomeostasiscellularresponsetogrowthfactorstimulusmulticellularorganismalresponsetostressmusclecontractionmyoblastfusionnegativeregulationofbloodpressurenegativeregulationofcalciumiontransportnegativeregulationofcalciumiontransportintocytosolnegativeregulationofhydrolaseactivitynegativeregulationofpotassiumiontransportnegativeregulationofserotoninuptakeneurotransmitterbiosyntheticprocessnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionpeptidyl-cysteineS-nitrosylationpositiveregulationofguanylatecyclaseactivitypositiveregulationofhistoneacetylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsodiumiontransmembranetransportpositiveregulationoftheforceofheartcontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofcalciumiontransmembranetransportviahighvoltage-gatedcalciumchannelregulationofcardiacmusclecontractionregulationofryanodine-sensitivecalcium-releasechannelactivityregulationofsodiumiontransportresponsetoheatresponsetohormoneresponsetohypoxiaresponsetolipopolysaccharideretrogradetrans-synapticsignalingbynitricoxidestriatedmusclecontractionvasodilationxenobioticcatabolicprocess
Immunoglobulin heavy constant gamma 1
250
Immunoglobulin heavy constant gamma 1
349
7.9
85
0.15
IGHG1IGHG1P01857P01857adaptiveimmuneresponseantibody-dependentcellularcytotoxicityBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Uncharacterized protein DKFZp686I04196
97
Tumor necrosis factor receptor superfamily member 13C
19
9.8
63
0.16
Q6N093TR13CQ6N093Q96RJ3adaptiveimmuneresponseBcellcostimulationpositiveregulationofBcellproliferationpositiveregulationofTcellproliferationTcellcostimulationtumornecrosisfactor-mediatedsignalingpathway
SUMO-activating enzyme subunit 2
173
Small ubiquitin-related modifier 1
95
9.3
75
0.14
SAE2SUMO1Q9UBT2P63165positiveregulationofproteinsumoylationproteinmodificationbysmallproteinconjugationproteinsumoylationcellularresponsetocadmiumioncellularresponsetoheatDNArepairnegativeregulationofactionpotentialnegativeregulationofdelayedrectifierpotassiumchannelactivitynegativeregulationofDNAbindingnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofproteinimportintonucleusnegativeregulationoftranscriptionbytranscriptionfactorlocalizationnegativeregulationoftranscriptionDNA-templatedPMLbodyorganizationpositiveregulationofATPase-coupledcalciumtransmembranetransporteractivitypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofprotein-containingcomplexassemblyproteinlocalizationtonuclearporeproteinstabilizationregulationofcardiacmusclecellcontractionregulationofproteinlocalizationroofofmouthdevelopment
Killer cell lectin-like receptor subfamily G member 1
75
Killer cell lectin-like receptor subfamily G member 1
75
8.6
nan
nan
KLRG1KLRG1O88713O88713cellsurfacereceptorsignalingpathwayinnateimmuneresponse
Insulin
95
Insulin
4
9.4
55
0.19
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
DNA polymerase theta
2527
DNA polymerase theta
2527
7.3
nan
nan
DPOLQDPOLQO75417O75417base-excisionrepaircellularresponsetoDNAdamagestimulusDNArepairDNA-templatedDNAreplicationdouble-strandbreakrepairdouble-strandbreakrepairviaalternativenonhomologousendjoiningnegativeregulationofdouble-strandbreakrepairviahomologousrecombinationproteinhomooligomerizationsomatichypermutationofimmunoglobulingenes
Endothelin-1
53
Endothelin-1
53
9.4
nan
nan
EDN1EDN1P05305P05305adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayarterysmoothmusclecontractionaxonextensionaxonogenesisinvolvedininnervationbodyfluidsecretionbranchinginvolvedinbloodvesselmorphogenesiscalciumiontransmembranetransportcalcium-mediatedsignalingcanonicalWntsignalingpathwaycardiacneuralcrestcellmigrationinvolvedinoutflowtractmorphogenesiscartilagedevelopmentcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularcalciumionhomeostasiscellularresponsetocalciumioncellularresponsetofattyacidcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetohumanchorionicgonadotropinstimuluscellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoluteinizinghormonestimuluscellularresponsetomineralocorticoidstimuluscellularresponsetoorganicsubstancecellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetotumornecrosisfactorcellularresponsetoxenobioticstimulusdorsal/ventralpatternformationembryonichearttubedevelopmentendothelinreceptorsignalingpathwayendothelinreceptorsignalingpathwayinvolvedinheartprocessepithelialfluidtransportERK1andERK2cascadeGprotein-coupledreceptorsignalingpathwayhistaminesecretionI-kappaBkinase/NF-kappaBsignalinginuteroembryonicdevelopmentinositolphosphate-mediatedsignalingleukocyteactivationmaternalprocessinvolvedinparturitionmeioticcellcycleprocessinvolvedinoocytematurationmembranedepolarizationmiddleearmorphogenesismitochondrionorganizationmulticellularorganismagingnegativeregulationofbloodcoagulationnegativeregulationofgeneexpressionnegativeregulationofhormonesecretionnegativeregulationofnitric-oxidesynthasebiosyntheticprocessnegativeregulationofproteinmetabolicprocessnegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneuralcrestcellfatecommitmentnitricoxidetransportnoradrenergicneurondifferentiationpeptidehormonesecretionpharyngealarcharterymorphogenesisphosphatidylinositol3-kinasesignalingphospholipaseD-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcardiacmusclehypertrophypositiveregulationofcationchannelactivitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellsizepositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellmigrationpositiveregulationofheartratepositiveregulationofhormonesecretionpositiveregulationofJUNkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofmitoticnucleardivisionpositiveregulationofneutrophilchemotaxispositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofodontogenesispositiveregulationofprostaglandinsecretionpositiveregulationofprostaglandin-endoperoxidesynthaseactivitypositiveregulationofrenalsodiumexcretionpositiveregulationofsarcomereorganizationpositiveregulationofsignalingreceptoractivitypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsmoothmusclecontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofurinevolumepositiveregulationofvascularassociatedsmoothmusclecellproliferationprostaglandinbiosyntheticprocessproteinkinaseAsignalingproteinkinaseCdeactivationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteinphosphorylationregulationofglucosetransmembranetransportregulationofpHregulationofsensoryperceptionofpainregulationofsystemicarterialbloodpressurebyendothelinregulationofvasoconstrictionrenalsodiumionabsorptionrespiratorygaseousexchangebyrespiratorysystemresponsetoactivityresponsetoaminoacidresponsetoamphetamineresponsetodexamethasoneresponsetoleptinresponsetolipopolysaccharideresponsetomusclestretchresponsetonicotineresponsetoozoneresponsetoprostaglandinFresponsetosaltresponsetotestosteronerhythmicexcitationsemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesensoryperceptionofpainsuperoxideaniongenerationsympatheticneuronaxonguidancethyroidglanddevelopmenttranscriptionbyRNApolymeraseIIvasoconstrictionveinsmoothmusclecontraction
HLA class II histocompatibility antigen, DQ alpha 1 chain
11
HLA class II histocompatibility antigen, DQ beta 1 chain
111
6.4
94
0.17
DQA1DQB1P01907P03992adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIimmuneresponsepeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivationhumoralimmuneresponseTcellreceptorsignalingpathway
Ubiquitin carboxyl-terminal hydrolase 2
485
Polyubiquitin-B
2
8.8
68
0.17
UBP2UBBO75604P0CG47cellcyclecircadianbehaviorcircadianregulationofgeneexpressionentrainmentofcircadianclockbyphotoperiodlocomotorrhythmmuscleorgandevelopmentnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofmitoticcellcycleproteindeubiquitinationproteinstabilizationregulationofsignaltransductionbyp53classmediatorubiquitin-dependentproteincatabolicprocessenergyhomeostasisfatpaddevelopmentfemalegonaddevelopmentfemalemeiosisIhypothalamusgonadotrophin-releasinghormoneneurondevelopmentmalemeiosisImitochondriontransportalongmicrotubulemodification-dependentproteincatabolicprocessneuronprojectionmorphogenesispositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofproteinmonoubiquitinationpositiveregulationofproteinubiquitinationproteinubiquitinationregulationofmitochondrialmembranepotentialregulationofneurondeathregulationofproteasomalproteincatabolicprocessseminiferoustubuledevelopment
Cryptochrome-1
414
Period circadian protein homolog 2
1213
3.9
59
0.43
CRY1PER2P97784O54943circadianregulationofgeneexpressioncircadianrhythmDNAdamageinducedproteinphosphorylationentrainmentofcircadianclockbyphotoperiodgluconeogenesisglucosehomeostasislipidstoragenegativeregulationofcircadianrhythmnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofglucocorticoidsecretionnegativeregulationofgluconeogenesisnegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofproteinubiquitinationregulationofcircadianrhythmregulationofDNAdamagecheckpointresponsetoactivityresponsetoglucagonresponsetoinsulinresponsetolightstimuluscircadianregulationoftranslationfattyacidmetabolicprocessglycogenbiosyntheticprocesshistoneH3deacetylationlactatebiosyntheticprocessnegativeregulationofDNA-templatedtranscriptionterminationnegativeregulationoffatcellproliferationnegativeregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationofcold-inducedthermogenesisregulationofcellcycleregulationofglutamateuptakeinvolvedintransmissionofnerveimpulseregulationofinsulinsecretionregulationofneurogenesisregulationofvasoconstrictionresponsetoischemiawhitefatcelldifferentiation
B-cell lymphoma 6 protein
8
B-cell lymphoma 6 protein
8
6.9
67
0.22
BCL6BCL6P41182P41182actincytoskeletonorganizationBcellproliferationcellmorphogenesiscell-matrixadhesioncellularresponsetoDNAdamagestimuluserythrocytedevelopmentgerminalcenterformationhistonedeacetylationinflammatoryresponseisotypeswitchingtoIgEisotypesnegativeregulationofBcellapoptoticprocessnegativeregulationofcellgrowthnegativeregulationofcell-matrixadhesionnegativeregulationofcellularsenescencenegativeregulationofisotypeswitchingtoIgEisotypesnegativeregulationofleukocyteproliferationnegativeregulationofmastcellcytokineproductionnegativeregulationofmitoticcellcycleDNAreplicationnegativeregulationofNotchsignalingpathwaynegativeregulationofplasmacelldifferentiationnegativeregulationofRhoproteinsignaltransductionnegativeregulationofT-helper2celldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedplasmacelldifferentiationpositiveregulationofapoptoticprocesspositiveregulationofBcellproliferationpositiveregulationofhistonedeacetylationpositiveregulationofneurondifferentiationpositiveregulationofregulatoryTcelldifferentiationproteinlocalizationpyramidalneurondifferentiationregulationofcelldifferentiationregulationofcellpopulationproliferationregulationofcytokineproductionregulationofgerminalcenterformationregulationofGTPaseactivityregulationofimmuneresponseregulationofimmunesystemprocessregulationofinflammatoryresponseregulationofmemoryTcelldifferentiationregulationofTcellproliferationregulationoftranscriptionbyRNApolymeraseIIRhoproteinsignaltransductionspermatogenesisT-helper2celldifferentiationtranscriptionbyRNApolymeraseIItype2immuneresponse
Insulin
31
Insulin
31
7.9
61
0.21
A6XGL2A6XGL2A6XGL2A6XGL2glucosemetabolicprocess
Defensin-6
72
Defensin-6
72
3.9
68
0.37
DEF6DEF6Q01524Q01524antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosakillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Protein cereblon
346
Protein cereblon
325
4.6
59
0.37
CRBNCRBNQ8C7D2Q8C7D2locomotoryexplorationbehaviornegativeregulationofiontransmembranetransportnegativeregulationoflargeconductancecalcium-activatedpotassiumchannelactivitynegativeregulationofprotein-containingcomplexassemblypositiveregulationofprotein-containingcomplexassemblyproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitination
C-type lectin domain family 4 member D
66
C-type lectin domain family 4 member D
83
5.3
85
0.22
CLC4DCLC4DQ8WXI8Q8WXI8adaptiveimmuneresponseantifungalinnateimmuneresponsedefenseresponsetobacteriumFc-gammareceptorsignalingpathwayimmuneresponsepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofmyeloiddendriticcellactivationTcelldifferentiationinvolvedinimmuneresponse
Platelet factor 4
43
Platelet factor 4
43
9.5
76
0.14
PLF4PLF4P02776P02776adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaycytokine-mediatedsignalingpathwaydefenseresponsetoprotozoaninflammatoryresponsekillingbyhostofsymbiontcellskillingofcellsofanotherorganismleukocytechemotaxisnegativeregulationofangiogenesisnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofmegakaryocytedifferentiationnegativeregulationofMHCclassIIbiosyntheticprocessneutrophilchemotaxisplateletactivationpositiveregulationofgeneexpressionpositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofmacrophagedifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionregulationofcellpopulationproliferation
Serine/threonine-protein kinase DCLK1
426
Serine/threonine-protein kinase DCLK1
548
4.6
58
0.37
DCLK1DCLK1O15075O15075axonextensioncentralnervoussystemdevelopmentcentralnervoussystemprojectionneuronaxonogenesisdendritemorphogenesisendosomaltransportforebraindevelopmentintracellularsignaltransductionnegativeregulationofproteinlocalizationtonucleusnervoussystemdevelopmentneuronmigrationneuronprojectionmorphogenesispeptidyl-serinephosphorylationproteinlocalizationtonucleusproteinphosphorylationresponsetovirus
Aurora kinase A
290
Aurora kinase A
290
5.3
41
0.46
1
✔AURKAAURKAO14965O14965anterior/posterioraxisspecificationapoptoticprocesscelldivisioncentrosomelocalizationciliumdisassemblyG2/Mtransitionofmitoticcellcycleliverregenerationmitoticcellcyclemitoticcentrosomeseparationmitoticspindleorganizationnegativeregulationofapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofproteinbindingneuronprojectionextensionpeptidyl-serinephosphorylationpositiveregulationofmitochondrialfissionpositiveregulationofmitoticnucleardivisionpositiveregulationofoocytematurationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautophosphorylationproteinlocalizationtocentrosomeproteinphosphorylationregulationofcentrosomecycleregulationofcytokinesisregulationofG2/Mtransitionofmitoticcellcycleregulationofproteinstabilityregulationofsignaltransductionbyp53classmediatorresponsetowoundingspindleassemblyinvolvedinfemalemeiosisIspindleorganization
Spondin-1
182
Spondin-1
156
8.4
66
0.18
SPON1SPON1Q9HCB6Q9HCB6celladhesionnegativeregulationofamyloid-betaformationpositiveregulationofamyloidprecursorproteincatabolicprocesspositiveregulationofproteinbindingpositiveregulationofproteinprocessingproteinprocessing
Vascular endothelial growth factor receptor 2
862
Vascular endothelial growth factor receptor 2
862
9.9
45
0.22
VGFR2VGFR2P35968P35968angiogenesisbloodvesselendothelialcelldifferentiationbranchinginvolvedinbloodvesselmorphogenesiscalciumionhomeostasiscalcium-mediatedsignalingusingintracellularcalciumsourcecellfatecommitmentcellmigrationcellmigrationinvolvedinsproutingangiogenesiscellularresponsetohydrogensulfidecellularresponsetovascularendothelialgrowthfactorstimulusembryonichemopoiesisendocardiumdevelopmentendothelialcelldifferentiationendotheliumdevelopmentepithelialcellmaturationepithelialcellproliferationERK1andERK2cascadehematopoieticprogenitorcelldifferentiationlungalveolusdevelopmentlymphvesseldevelopmentmesenchymalcellproliferationnegativeregulationofapoptoticprocessnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofneuronapoptoticprocessovarianfollicledevelopmentpeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofBMPsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffocaladhesionassemblypositiveregulationofkinaseactivitypositiveregulationofmacroautophagypositiveregulationofMAPKcascadepositiveregulationofmesenchymalcellproliferationpositiveregulationofmitochondrialdepolarizationpositiveregulationofmitochondrialfissionpositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofpositivechemotaxispositiveregulationofproteinphosphorylationpositiveregulationofstemcellproliferationpositiveregulationofvasculogenesispost-embryoniccamera-typeeyemorphogenesisproteinautophosphorylationproteinkinaseBsignalingregulationofbonedevelopmentregulationofcellshaperegulationofhematopoieticprogenitorcelldifferentiationsemaphorin-plexinsignalingpathwaystemcellproliferationsurfactanthomeostasistransmembranereceptorproteintyrosinekinasesignalingpathwayvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorreceptor-2signalingpathwayvascularendothelialgrowthfactorsignalingpathwayvascularwoundhealingvasculogenesis
Neuronal calcium sensor 1
38
Neuronal calcium sensor 1
38
6.8
62
0.24
NCS1NCS1P62168P62168phosphatidylinositol-mediatedsignalingpositiveregulationofexocytosisregulationofneuronprojectiondevelopmentregulationofsynapticvesicleexocytosis
PRSS3 protein
52
Amyloid beta precursor like protein 2
319
9.0
89
0.12
Q8N2U3APLP2Q8N2U3Q06481proteolysisaxonogenesiscentralnervoussystemdevelopmentGprotein-coupledreceptorsignalingpathwayregulationofcellularproteinmetabolicprocess
Glycylpeptide N-tetradecanoyltransferase 1
294
Apoptosis-inducing factor 3
4
10.0
78
0.13
NMT1AIFM3P30419Q96NN9cellularketonemetabolicprocessinuteroembryonicdevelopmentN-terminalpeptidyl-glycineN-myristoylationN-terminalproteinmyristoylationpositiveregulationofproteininsertionintomitochondrialmembraneinvolvedinapoptoticsignalingpathwayregulationofrhodopsinmediatedsignalingpathwayexecutionphaseofapoptosis
Protein farnesyltransferase subunit beta
366
GTPase KRas
186
9.7
82
0.13
FNTBRASKQ02293P01116lipidmetabolicprocessnegativeregulationofcellpopulationproliferationpositiveregulationofcellcyclepositiveregulationofcellpopulationproliferationpositiveregulationoffibroblastproliferationpositiveregulationofnitric-oxidesynthasebiosyntheticprocessproteinfarnesylationproteinprenylationregulationoffibroblastproliferationresponsetocytokineresponsetoinorganicsubstanceresponsetoorganiccycliccompoundwoundhealingactincytoskeletonorganizationendocrinesignalingepithelialtubebranchinginvolvedinlungmorphogenesisforebrainastrocytedevelopmentglialcellproliferationhomeostasisofnumberofcellswithinatissueMAPKcascadenegativeregulationofepithelialcelldifferentiationnegativeregulationofneuronapoptoticprocessneuronapoptoticprocesspositiveregulationofgeneexpressionpositiveregulationofglialcellproliferationpositiveregulationofproteinphosphorylationpositiveregulationofRacproteinsignaltransductionRacproteinsignaltransductionRasproteinsignaltransductionregulationoflong-termneuronalsynapticplasticityregulationofproteinstabilityregulationofsynaptictransmissionGABAergicskeletalmusclecelldifferentiationstriatedmusclecelldifferentiationtypeIpneumocytedifferentiationvisuallearning
Cartilage oligomeric matrix protein
68
Cartilage oligomeric matrix protein
71
9.9
53
0.19
COMPCOMPP35444P35444apoptoticprocessarterymorphogenesisbloodcoagulationBMPsignalingpathwaybonegrowthbonemineralizationbonemorphogenesiscartilagedevelopmentcartilagehomeostasischondrocytedevelopmentchondrocyteproliferationcollagenfibrilorganizationendochondralbonegrowthgrowthplatecartilagedevelopmentlimbdevelopmentmulticellularorganismagingmulticellularorganismgrowthmusclecelldevelopmentmusculoskeletalmovementnegativeregulationofapoptoticprocessnegativeregulationofhemostasisneuromuscularprocessossificationplateletaggregationpositiveregulationofchondrocyteproliferationproteinhomooligomerizationproteinprocessingproteinsecretionregulationofbonemineralizationregulationofgeneexpressionresponsetounfoldedproteinskeletalsystemdevelopmentskindevelopmenttendondevelopmentvascularassociatedsmoothmusclecelldevelopmentvascularassociatedsmoothmusclecontraction
Neutrophil defensin 3
94
Neutrophil defensin 3
66
9.9
nan
nan
DEF3DEF3P59666P59666antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetovirusinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Ral guanine nucleotide dissociation stimulator
780
Ral guanine nucleotide dissociation stimulator
781
6.3
61
0.26
GNDSGNDSQ03386Q03386positiveregulationofGTPaseactivityRasproteinsignaltransductionsmallGTPasemediatedsignaltransduction
Protein kinase C delta type
280
Protein kinase C delta type
247
9.1
nan
nan
A0A140UHX0A0A140UHX0A0A140UHX0A0A140UHX0apoptoticprocesscellcycleproteinphosphorylation
Interleukin-4
27
Cytokine receptor common subunit gamma
231
7.9
nan
nan
IL4IL2RGP05112P31785activationofJanuskinaseactivityBcellcostimulationBcelldifferentiationcholesterolmetabolicprocessdendriticcelldifferentiationextrinsicapoptoticsignalingpathwayinabsenceofligandimmuneresponseinnateimmuneresponseinmucosamacrophageactivationmicroglialcellactivationmyeloiddendriticcelldifferentiationnegativeregulationofacuteinflammatoryresponsenegativeregulationofapoptoticprocessnegativeregulationofcellularresponsetotransforminggrowthfactorbetastimulusnegativeregulationofchronicinflammatoryresponsenegativeregulationofcomplement-dependentcytotoxicitynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofepithelialcellmigrationnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofinflammatoryresponsenegativeregulationofmacrophageactivationnegativeregulationofneuroinflammatoryresponsenegativeregulationofosteoclastdifferentiationnegativeregulationofT-helper17celldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftumornecrosisfactorproductionneuroinflammatoryresponsepositiveregulationofamyloid-betaclearancepositiveregulationofATPbiosyntheticprocesspositiveregulationofBcellproliferationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellularrespirationpositiveregulationofcold-inducedthermogenesispositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofeosinophilchemotaxispositiveregulationofgeneexpressionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-13productionpositiveregulationofisotypeswitchingtoIgEisotypespositiveregulationofisotypeswitchingtoIgGisotypespositiveregulationofmacroautophagypositiveregulationofmastcelldegranulationpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofmononuclearcellmigrationpositiveregulationofmyoblastfusionpositiveregulationofreceptor-mediatedendocytosispositiveregulationofTcelldifferentiationpositiveregulationofTcellproliferationpositiveregulationofT-helper2cellcytokineproductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofimmuneresponseregulationofisotypeswitchingregulationofphosphorylationTcellactivationT-helper2celldifferentiationtype2immuneresponseCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationcytokine-mediatedsignalingpathwaygeneexpressioninterleukin-15-mediatedsignalingpathwayinterleukin-2-mediatedsignalingpathwayinterleukin-4-mediatedsignalingpathwayinterleukin-7-mediatedsignalingpathwaymatureBcelldifferentiationpositiveregulationofBcelldifferentiationpositiveregulationofCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationpositiveregulationofphagocytosispositiveregulationofTcelldifferentiationinthymussignaltransductionTcelldifferentiationinthymus
Interleukin-4
151
Cytokine receptor common subunit gamma
182
9.1
nan
nan
D4HNR6IL2RGD4HNR6P31785BcellactivationimmuneresponseCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationcytokine-mediatedsignalingpathwaygeneexpressioninterleukin-15-mediatedsignalingpathwayinterleukin-2-mediatedsignalingpathwayinterleukin-4-mediatedsignalingpathwayinterleukin-7-mediatedsignalingpathwaymatureBcelldifferentiationpositiveregulationofBcelldifferentiationpositiveregulationofCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationpositiveregulationofgeneexpressionpositiveregulationofphagocytosispositiveregulationofTcelldifferentiationinthymussignaltransductionTcelldifferentiationinthymus
Neuropilin-1
275
Neuropilin-1
424
9.1
73
0.15
NRP1NRP1O14786O14786actincytoskeletonreorganizationangiogenesisangiogenesisinvolvedincoronaryvascularmorphogenesisanimalorganmorphogenesisarterymorphogenesisaxonextensioninvolvedinaxonguidanceaxonguidanceaxonalfasciculationaxonogenesisinvolvedininnervationbasaldendritearborizationbasaldendritedevelopmentbranchinginvolvedinbloodvesselmorphogenesisbranchiomotorneuronaxonguidancecellmigrationinvolvedinsproutingangiogenesiscell-cellsignalingcellularresponsetohepatocytegrowthfactorstimuluscellularresponsetovascularendothelialgrowthfactorstimuluscommissuralneuronaxonguidancecoronaryarterymorphogenesisdichotomoussubdivisionofterminalunitsinvolvedinsalivaryglandbranchingdorsalrootganglionmorphogenesisendothelialcellchemotaxisendothelialcellmigrationendothelialtipcellfatespecificationfacialnervestructuralorganizationfacioacousticgangliondevelopmentgonadotrophin-releasinghormoneneuronalmigrationtothehypothalamushepatocytegrowthfactorreceptorsignalingpathwayintegrin-mediatedsignalingpathwaymotorneuronmigrationnegativeregulationofaxonextensioninvolvedinaxonguidancenegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofneuronapoptoticprocessnervedevelopmentneuralcrestcellmigrationneuralcrestcellmigrationinvolvedinautonomicnervoussystemdevelopmentneuronmigrationneuropilinsignalingpathwayoticplacodedevelopmentoutflowtractseptummorphogenesisplatelet-derivedgrowthfactorreceptorsignalingpathwaypositivechemotaxispositiveregulationofactincytoskeletonreorganizationpositiveregulationofangiogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcytokineactivitypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffilopodiumassemblypositiveregulationoffocaladhesionassemblypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphorylationpositiveregulationofretinalganglioncellaxonguidancepositiveregulationofsmoothmusclecellmigrationpositiveregulationofstressfiberassemblypositiveregulationofsubstrateadhesion-dependentcellspreadingpostsynapseorganizationproteinlocalizationtoearlyendosomeregulationofCdc42proteinsignaltransductionregulationofretinalganglioncellaxonguidanceregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofvesicle-mediatedtransportrenalarterymorphogenesisresponsetowoundingretinavasculaturemorphogenesisincamera-typeeyeretinalganglioncellaxonguidancesemaphorin-plexinsignalingpathwaysemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesemaphorin-plexinsignalingpathwayinvolvedinneuronprojectionguidancesensoryneuronaxonguidancesignaltransductionsproutingangiogenesissubstrateadhesion-dependentcellspreadingsubstrate-dependentcellmigrationcellextensionsympatheticgangliondevelopmentsympatheticneuronprojectionextensionsympatheticneuronprojectionguidancetoxintransporttrigeminalgangliondevelopmenttrigeminalnervestructuralorganizationvascularendothelialgrowthfactorreceptorsignalingpathwayvasculogenesisVEGF-activatedneuropilinsignalingpathwayVEGF-activatedneuropilinsignalingpathwayinvolvedinaxonguidanceventraltrunkneuralcrestcellmigrationvestibulocochlearnervestructuralorganizationviralentryintohostcell
Interleukin-4
27
Cytokine receptor common subunit gamma
231
9.1
nan
nan
D4HNR6IL2RGD4HNR6P31785BcellactivationimmuneresponseCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationcytokine-mediatedsignalingpathwaygeneexpressioninterleukin-15-mediatedsignalingpathwayinterleukin-2-mediatedsignalingpathwayinterleukin-4-mediatedsignalingpathwayinterleukin-7-mediatedsignalingpathwaymatureBcelldifferentiationpositiveregulationofBcelldifferentiationpositiveregulationofCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationpositiveregulationofgeneexpressionpositiveregulationofphagocytosispositiveregulationofTcelldifferentiationinthymussignaltransductionTcelldifferentiationinthymus
Coagulation factor VII
238
Pancreatic trypsin inhibitor
49
9.4
100
0.11
FA7BPT1P08709P00974activationofbloodcoagulationviaclottingcascadeanimalorganregenerationbloodcoagulationbloodcoagulationextrinsicpathwaybloodcoagulationfibrinclotformationbloodcoagulationintrinsicpathwaycircadianrhythmpositiveregulationofbloodcoagulationpositiveregulationofcellmigrationpositiveregulationofleukocytechemotaxispositiveregulationofplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofpositivechemotaxispositiveregulationofproteinkinaseBsignalingproteinprocessingproteolysisresponseto2378-tetrachlorodibenzodioxineresponsetoanticoagulantresponsetoastaxanthinresponsetocarbondioxideresponsetocholesterolresponsetoestradiolresponsetoestrogenresponsetogenisteinresponsetogrowthhormoneresponsetohypoxiaresponsetoThyroidstimulatinghormoneresponsetothyrotropin-releasinghormoneresponsetothyroxineresponsetovitaminKresponsetowoundingzymogenactivationnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Amyloid-beta precursor protein
174
Amyloid-beta precursor protein
133
7.3
77
0.18
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Thrombomodulin
480
Thrombomodulin
451
10.0
66
0.15
TRBMTRBMP07204P07204bloodcoagulationbloodcoagulationcommonpathwayfemalepregnancynegativeregulationofbloodcoagulationnegativeregulationoffibrinolysisnegativeregulationofplateletactivationproteolysisresponsetocAMPresponsetolipopolysaccharideresponsetoX-rayzymogenactivation
Protein farnesyltransferase subunit beta
366
GTPase KRas
186
9.8
76
0.13
FNTBRASKQ02293P01118lipidmetabolicprocessnegativeregulationofcellpopulationproliferationpositiveregulationofcellcyclepositiveregulationofcellpopulationproliferationpositiveregulationoffibroblastproliferationpositiveregulationofnitric-oxidesynthasebiosyntheticprocessproteinfarnesylationproteinprenylationregulationoffibroblastproliferationresponsetocytokineresponsetoinorganicsubstanceresponsetoorganiccycliccompoundwoundhealingactincytoskeletonorganizationendocrinesignalingepithelialtubebranchinginvolvedinlungmorphogenesisforebrainastrocytedevelopmentglialcellproliferationhomeostasisofnumberofcellswithinatissueMAPKcascadenegativeregulationofepithelialcelldifferentiationnegativeregulationofneuronapoptoticprocessneuronapoptoticprocesspositiveregulationofgeneexpressionpositiveregulationofglialcellproliferationpositiveregulationofproteinphosphorylationpositiveregulationofRacproteinsignaltransductionRacproteinsignaltransductionRasproteinsignaltransductionregulationoflong-termneuronalsynapticplasticityregulationofproteinstabilityregulationofsynaptictransmissionGABAergicskeletalmusclecelldifferentiationstriatedmusclecelldifferentiationtypeIpneumocytedifferentiationvisuallearning
Neutrophil defensin 1
66
Neutrophil defensin 1
93
10.0
74
0.14
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismmodificationbyhostofsymbiontmembraneTcellchemotaxis
Ephrin type-A receptor 2
201
Ephrin-A1
80
9.9
nan
nan
EPHA2EFNA1P29317P20827activationofGTPaseactivityaxialmesodermformationaxonguidancebloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisboneremodelingbranchinginvolvedinmammaryglandductmorphogenesiscAMPmetabolicprocesscelladhesioncellchemotaxiscellmigrationcellmotilitydefenseresponsetoGram-positivebacteriumephrinreceptorsignalingpathwayinflammatoryresponseintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagekeratinocytedifferentiationlensfibercellmorphogenesismammaryglandepithelialcellproliferationnegativeregulationofangiogenesisnegativeregulationofchemokineproductionnegativeregulationoflymphangiogenesisnegativeregulationofproteinkinaseBsignalingneuraltubedevelopmentnotochordcelldevelopmentnotochordformationosteoblastdifferentiationosteoclastdifferentiationpericytecelldifferentiationpositiveregulationofbicellulartightjunctionassemblypositiveregulationofcellmigrationpositiveregulationofkinaseactivitypositiveregulationofproteinlocalizationtoplasmamembranepost-analtailmorphogenesisproteinkinaseBsignalingproteinlocalizationtoplasmamembraneregulationofangiogenesisregulationofbloodvesselendothelialcellmigrationregulationofcelladhesionmediatedbyintegrinregulationofERK1andERK2cascaderegulationoflamellipodiumassemblyresponsetogrowthfactorskeletalsystemdevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathwayvasculogenesisangiogenesisaorticvalvemorphogenesiscell-cellsignalingendocardialcushiontomesenchymaltransitioninvolvedinheartvalveformationmitralvalvemorphogenesisnegativeregulationofdendriticspinemorphogenesisnegativeregulationofepithelialtomesenchymaltransitionnegativeregulationofMAPKcascadenegativeregulationofproteolysisinvolvedinproteincatabolicprocessnegativeregulationofthymocyteapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofamyloid-betaformationpositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofMAPKcascadepositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivityproteinstabilizationregulationofaxonogenesisregulationofpeptidyl-tyrosinephosphorylationsubstrateadhesion-dependentcellspreading
Platelet factor 4 variant
46
Platelet factor 4 variant
46
9.8
71
0.14
PF4VPF4VP10720P10720antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwayinflammatoryresponseneutrophilchemotaxisplateletactivation
Albumin
582
Albumin
582
6.2
nan
nan
ALBUALBUP02769P02769cellularresponsetostarvationmaintenanceofmitochondrionlocationnegativeregulationofapoptoticprocess
Natural killer cells antigen CD94
59
NKG2-A/NKG2-B type II integral membrane protein
116
5.8
nan
nan
KLRD1NKG2AQ13241P26715adaptiveimmuneresponsecellsurfacereceptorsignalingpathwaynaturalkillercellmediatedimmunitynegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofTcellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicityregulationofnaturalkillercellactivationstimulatoryC-typelectinreceptorsignalingpathwayCD8-positivegamma-deltaintraepithelialTcelldifferentiationinnateimmuneresponsenaturalkillercellinhibitorysignalingpathway
Prothrombin
594
Prothrombin
594
9.8
nan
nan
THRBTHRBP00734P00734acute-phaseresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidebloodcoagulationbloodcoagulationcommonpathwaycellsurfacereceptorsignalingpathwaycytolysisbyhostofsymbiontcellsfibrinolysisnegativeregulationofastrocytedifferentiationnegativeregulationofbloodcoagulationnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationoffibrinolysisnegativeregulationofplateletactivationnegativeregulationofproteolysisneutrophil-mediatedkillingofgram-negativebacteriumplateletactivationpositiveregulationofbloodcoagulationpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationoflipidkinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinphosphorylationpositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofreleaseofsequesteredcalciumionintocytosolproteolysisregulationofbloodcoagulationregulationofcellshaperegulationofcytosoliccalciumionconcentrationresponsetowoundingzymogenactivation
14-3-3 protein gamma
194
E3 ubiquitin-protein ligase NEDD4-like
341
10.0
nan
nan
1433GNED4LP61981Q96PU5cellularresponsetoinsulinstimulusnegativeregulationofproteinkinaseactivityproteinlocalizationproteintargetingregulationofneurondifferentiationregulationofsignaltransductionregulationofsynapticplasticitysignaltransductioncelldifferentiationiontransmembranetransportnegativeregulationofpotassiumiontransmembranetransportnegativeregulationofpotassiumiontransmembranetransporteractivitynegativeregulationofproteinlocalizationtocellsurfacenegativeregulationofsodiumiontransmembranetransportnegativeregulationofsodiumiontransmembranetransporteractivitypositiveregulationofcaveolin-mediatedendocytosispositiveregulationofdendriteextensionproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinK48-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationofdendritemorphogenesisregulationofiontransmembranetransportregulationofmembranedepolarizationregulationofmembranepotentialregulationofmembranerepolarizationregulationofpotassiumiontransmembranetransporteractivityregulationofproteinstabilityregulationofsodiumiontransmembranetransportubiquitin-dependentproteincatabolicprocessventricularcardiacmusclecellactionpotential
Complement factor H
1218
Complement factor H
1218
9.9
44
0.23
CFAHCFAHP08603P08603complementactivationcomplementactivationalternativepathwayproteolysisregulationofcomplementactivationregulationofcomplementactivationalternativepathwayregulationofcomplement-dependentcytotoxicity
Interleukin-4
27
Cytokine receptor common subunit gamma
182
10.0
nan
nan
D4HNR6IL2RGD4HNR6P31785BcellactivationimmuneresponseCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationcytokine-mediatedsignalingpathwaygeneexpressioninterleukin-15-mediatedsignalingpathwayinterleukin-2-mediatedsignalingpathwayinterleukin-4-mediatedsignalingpathwayinterleukin-7-mediatedsignalingpathwaymatureBcelldifferentiationpositiveregulationofBcelldifferentiationpositiveregulationofCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationpositiveregulationofgeneexpressionpositiveregulationofphagocytosispositiveregulationofTcelldifferentiationinthymussignaltransductionTcelldifferentiationinthymus
Insulin-like growth factor-binding protein 4
174
Insulin-like growth factor I
54
6.1
78
0.21
IBP4IGF1P22692P05019inflammatoryresponseMAPKcascadenegativeregulationofcanonicalWntsignalingpathwaypositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascaderegulationofcellgrowthregulationofglucosemetabolicprocessregulationofinsulin-likegrowthfactorreceptorsignalingpathwaysignaltransductiontypeBpancreaticcellproliferationactivationofproteinkinaseBactivitybonemineralizationinvolvedinbonematurationcellactivationcellpopulationproliferationcellularresponsetoamyloid-betaERK1andERK2cascadeglycolatemetabolicprocessinsulin-likegrowthfactorreceptorsignalingpathwaymusclehypertrophymuscleorgandevelopmentmyoblastdifferentiationmyoblastproliferationmyotubecelldevelopmentnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofinterleukin-1betaproductionnegativeregulationofneuroinflammatoryresponsenegativeregulationofoocytedevelopmentnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftumornecrosisfactorproductionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcardiacmusclehypertrophypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRasproteinsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftrophectodermalcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseBsignalingproteinstabilizationproteoglycanbiosyntheticprocessRasproteinsignaltransductionregulationofgeneexpressionregulationofmulticellularorganismgrowthregulationofproteinphosphorylationresponsetoheatskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationskeletalsystemdevelopmentwoundhealing
NKG2-D type II integral membrane protein
112
NKG2-D type II integral membrane protein
112
6.4
76
0.2
NKG2DNKG2DO54709O54709adaptiveimmuneresponsecelldifferentiationcellularresponsetolipopolysaccharidedefenseresponsetoGram-positivebacteriumnaturalkillercellactivationnaturalkillercellmediatedcytotoxicitynegativeregulationofGTPaseactivitynegativeregulationofnaturalkillercellchemotaxisnitricoxidebiosyntheticprocesspositiveregulationofapoptoticprocesspositiveregulationofinterferon-gammaproductionpositiveregulationofmyeloiddendriticcellactivationpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationofnitricoxidebiosyntheticprocessstimulatoryC-typelectinreceptorsignalingpathway
Neuropilin-1
424
Neuropilin-1
424
9.6
68
0.15
NRP1NRP1O14786O14786actincytoskeletonreorganizationangiogenesisangiogenesisinvolvedincoronaryvascularmorphogenesisanimalorganmorphogenesisarterymorphogenesisaxonextensioninvolvedinaxonguidanceaxonguidanceaxonalfasciculationaxonogenesisinvolvedininnervationbasaldendritearborizationbasaldendritedevelopmentbranchinginvolvedinbloodvesselmorphogenesisbranchiomotorneuronaxonguidancecellmigrationinvolvedinsproutingangiogenesiscell-cellsignalingcellularresponsetohepatocytegrowthfactorstimuluscellularresponsetovascularendothelialgrowthfactorstimuluscommissuralneuronaxonguidancecoronaryarterymorphogenesisdichotomoussubdivisionofterminalunitsinvolvedinsalivaryglandbranchingdorsalrootganglionmorphogenesisendothelialcellchemotaxisendothelialcellmigrationendothelialtipcellfatespecificationfacialnervestructuralorganizationfacioacousticgangliondevelopmentgonadotrophin-releasinghormoneneuronalmigrationtothehypothalamushepatocytegrowthfactorreceptorsignalingpathwayintegrin-mediatedsignalingpathwaymotorneuronmigrationnegativeregulationofaxonextensioninvolvedinaxonguidancenegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofneuronapoptoticprocessnervedevelopmentneuralcrestcellmigrationneuralcrestcellmigrationinvolvedinautonomicnervoussystemdevelopmentneuronmigrationneuropilinsignalingpathwayoticplacodedevelopmentoutflowtractseptummorphogenesisplatelet-derivedgrowthfactorreceptorsignalingpathwaypositivechemotaxispositiveregulationofactincytoskeletonreorganizationpositiveregulationofangiogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcytokineactivitypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffilopodiumassemblypositiveregulationoffocaladhesionassemblypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphorylationpositiveregulationofretinalganglioncellaxonguidancepositiveregulationofsmoothmusclecellmigrationpositiveregulationofstressfiberassemblypositiveregulationofsubstrateadhesion-dependentcellspreadingpostsynapseorganizationproteinlocalizationtoearlyendosomeregulationofCdc42proteinsignaltransductionregulationofretinalganglioncellaxonguidanceregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofvesicle-mediatedtransportrenalarterymorphogenesisresponsetowoundingretinavasculaturemorphogenesisincamera-typeeyeretinalganglioncellaxonguidancesemaphorin-plexinsignalingpathwaysemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesemaphorin-plexinsignalingpathwayinvolvedinneuronprojectionguidancesensoryneuronaxonguidancesignaltransductionsproutingangiogenesissubstrateadhesion-dependentcellspreadingsubstrate-dependentcellmigrationcellextensionsympatheticgangliondevelopmentsympatheticneuronprojectionextensionsympatheticneuronprojectionguidancetoxintransporttrigeminalgangliondevelopmenttrigeminalnervestructuralorganizationvascularendothelialgrowthfactorreceptorsignalingpathwayvasculogenesisVEGF-activatedneuropilinsignalingpathwayVEGF-activatedneuropilinsignalingpathwayinvolvedinaxonguidanceventraltrunkneuralcrestcellmigrationvestibulocochlearnervestructuralorganizationviralentryintohostcell
Hepatocyte growth factor
207
Hepatocyte growth factor
207
4.5
58
0.39
HGFHGFQ08048Q08048animalorganregenerationcellchemotaxiscellmorphogenesiscellularresponsetohepatocytegrowthfactorstimulusepithelialcellproliferationhepatocytegrowthfactorreceptorsignalingpathwayliverdevelopmentmyoblastproliferationnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-6productionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofreleaseofcytochromecfrommitochondriapositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofinterleukin-10productionpositiveregulationofMAPKcascadepositiveregulationofmyelinationpositiveregulationofneuronprojectionregenerationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationproteolysisregulationofbranchinginvolvedinsalivaryglandmorphogenesisbymesenchymal-epithelialsignalingregulationofp38MAPKcascaderegulationoftau-proteinkinaseactivityskeletalmusclecellproliferation
Transcription initiation factor IIA subunit 1
337
Transcription initiation factor IIA subunit 2
98
8.6
72
0.16
TF2AAT2AGP52655P52657positiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationfromRNApolymeraseIIpromoterRNApolymeraseIIpreinitiationcomplexassemblytranscriptionbyRNApolymeraseIItranscriptioninitiationfromRNApolymeraseIIpromoter
Cytochrome P450 2D6
57
Cytochrome P450 2D6
57
9.7
47
0.22
CP2D6CP2D6P10635P10635alkaloidcatabolicprocessalkaloidmetabolicprocessarachidonicacidmetabolicprocesscholesterolmetabolicprocesscoumarinmetabolicprocessestrogenmetabolicprocessheterocyclemetabolicprocessisoquinolinealkaloidmetabolicprocesslong-chainfattyacidbiosyntheticprocessmonoterpenoidmetabolicprocessnegativeregulationofbindingnegativeregulationofcellularorganofluorinemetabolicprocessorganicacidmetabolicprocessoxidativedemethylationretinolmetabolicprocesssteroidmetabolicprocessxenobioticcatabolicprocessxenobioticmetabolicprocess
PRSS3 protein
68
Amyloid beta precursor like protein 2
319
8.5
88
0.13
Q8N2U3APLP2Q8N2U3Q06481proteolysisaxonogenesiscentralnervoussystemdevelopmentGprotein-coupledreceptorsignalingpathwayregulationofcellularproteinmetabolicprocess
Sorting nexin-17
320
Krev interaction trapped protein 1
228
3.5
48
0.6
SNX17KRIT1Q15036O00522aortadevelopmentcardiacseptumdevelopmentcholesterolcatabolicprocesscoronaryvasculaturedevelopmentendocyticrecyclingendosomaltransportintracellularproteintransportkidneydevelopmentreceptor-mediatedendocytosisregulationofendocytosissignaltransductionangiogenesiscellredoxhomeostasisendotheliumdevelopmentintegrinactivationnegativeregulationofangiogenesisnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofendothelialcellmigrationnegativeregulationofendothelialcellproliferationpositiveregulationofproteinbindingregulationofangiogenesisregulationofestablishmentofcellpolaritysmallGTPasemediatedsignaltransduction
Hepatocyte growth factor
487
Hepatocyte growth factor
612
9.3
70
0.15
HGFHGFP14210P14210animalorganregenerationcellchemotaxiscellmorphogenesiscellularresponsetohepatocytegrowthfactorstimulusepithelialcellproliferationepithelialtomesenchymaltransitionhepatocytegrowthfactorreceptorsignalingpathwayliverdevelopmentmitoticcellcyclemyoblastproliferationnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-6productionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofreleaseofcytochromecfrommitochondriapositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofinterleukin-10productionpositiveregulationofMAPKcascadepositiveregulationofmyelinationpositiveregulationofneuronprojectionregenerationpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofbranchinginvolvedinsalivaryglandmorphogenesisbymesenchymal-epithelialsignalingregulationofp38MAPKcascaderegulationoftau-proteinkinaseactivityskeletalmusclecellproliferation
Protein-arginine deiminase type-3
564
Protein-arginine deiminase type-3
125
9.9
39
0.26
PADI3PADI3Q9ULW8Q9ULW8histonecitrullination
E3 ubiquitin-protein ligase XIAP
351
E3 ubiquitin-protein ligase XIAP
351
3.0
36
0.92
XIAPXIAPP98170P98170cellularresponsetoDNAdamagestimuluscopperionhomeostasisinhibitionofcysteine-typeendopeptidaseactivityinhibitionofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationoftumornecrosisfactor-mediatedsignalingpathwayneuronapoptoticprocesspositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofJNKcascadepositiveregulationofproteinlinearpolyubiquitinationpositiveregulationofproteinubiquitinationregulationofapoptosisinvolvedintissuehomeostasisregulationofapoptoticprocessregulationofBMPsignalingpathwayregulationofcellcycleregulationofcellpopulationproliferationregulationofinflammatoryresponseregulationofinnateimmuneresponseregulationofnucleotide-bindingoligomerizationdomaincontainingsignalingpathwayWntsignalingpathway
Vam6/Vps39-like protein
877
Vam6/Vps39-like protein
852
8.7
47
0.24
VPS39VPS39Q96JC1Q96JC1autophagosome-lysosomefusionautophagyendocyticrecyclingendosomalvesiclefusionendosometolysosometransportintracellularproteintransportlateendosometolysosometransportregulationofSNAREcomplexassembly
Hepatocyte growth factor
487
Hepatocyte growth factor
679
8.0
73
0.17
HGFHGFP14210P14210animalorganregenerationcellchemotaxiscellmorphogenesiscellularresponsetohepatocytegrowthfactorstimulusepithelialcellproliferationepithelialtomesenchymaltransitionhepatocytegrowthfactorreceptorsignalingpathwayliverdevelopmentmitoticcellcyclemyoblastproliferationnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-6productionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofreleaseofcytochromecfrommitochondriapositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofinterleukin-10productionpositiveregulationofMAPKcascadepositiveregulationofmyelinationpositiveregulationofneuronprojectionregenerationpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofbranchinginvolvedinsalivaryglandmorphogenesisbymesenchymal-epithelialsignalingregulationofp38MAPKcascaderegulationoftau-proteinkinaseactivityskeletalmusclecellproliferation
LINE-1 type transposase domain-containing protein 1
278
LINE-1 type transposase domain-containing protein 1
278
3.5
57
0.5
LITD1LITD1Q5T7N2Q5T7N2transpositionRNA-mediated
Geranylgeranyl transferase type-2 subunit beta
240
Synaptobrevin homolog YKT6
194
3.5
nan
nan
PGTB2YKT6P53611O15498proteingeranylgeranylationproteinmodificationprocessproteinprenylationvisualperceptionendoplasmicreticulumtoGolgivesicle-mediatedtransportproteintransportretrogradetransportendosometoGolgivesicledockinginvolvedinexocytosisvesicletargeting
G1/S-specific cyclin-D1
7
Cyclin-dependent kinase 4
135
4.7
41
0.52
CCND1CDK4P24385P11802celldivisioncellularresponsetoDNAdamagestimulusendoplasmicreticulumunfoldedproteinresponsefatcelldifferentiationG1/StransitionofmitoticcellcyclelactationLeydigcelldifferentiationliverregenerationmammaryglandalveolusdevelopmentmammaryglandepithelialcellproliferationmitoticcellcyclephasetransitionmitoticG1DNAdamagecheckpointsignalingnegativeregulationofepithelialcelldifferentiationnegativeregulationofneuronapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneurondifferentiationpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofmammaryglandepithelialcellproliferationpositiveregulationofproteinphosphorylationproteinphosphorylationre-entryintomitoticcellcycleregulationofcyclin-dependentproteinserine/threoninekinaseactivityresponsetocalciumionresponsetocorticosteroneresponsetoestradiolresponsetoestrogenresponsetoethanolresponsetoironionresponsetoleptinresponsetomagnesiumionresponsetoorganonitrogencompoundresponsetoUV-AresponsetovitaminEresponsetoX-rayresponsetoxenobioticstimulusWntsignalingpathwayadiposetissuedevelopmentcellularresponsetoinsulinstimuluscellularresponsetointerleukin-4cellularresponsetoionomycincellularresponsetolipopolysaccharidecellularresponsetophorbol13-acetate12-myristatepositiveregulationofcellpopulationproliferationpositiveregulationoffibroblastproliferationregulationofcellcycleregulationofgeneexpressionregulationofinsulinreceptorsignalingpathwayregulationoflipidbiosyntheticprocessregulationoflipidcatabolicprocessregulationofmulticellularorganismgrowthregulationoftranscriptioninitiationfromRNApolymeraseIIpromoterregulationoftypeBpancreaticcellproliferationsignaltransduction
Protein farnesyltransferase subunit beta
299
GTPase KRas
186
4.1
68
0.36
FNTBRASKQ02293P01118lipidmetabolicprocessnegativeregulationofcellpopulationproliferationpositiveregulationofcellcyclepositiveregulationofcellpopulationproliferationpositiveregulationoffibroblastproliferationpositiveregulationofnitric-oxidesynthasebiosyntheticprocessproteinfarnesylationproteinprenylationregulationoffibroblastproliferationresponsetocytokineresponsetoinorganicsubstanceresponsetoorganiccycliccompoundwoundhealingactincytoskeletonorganizationendocrinesignalingepithelialtubebranchinginvolvedinlungmorphogenesisforebrainastrocytedevelopmentglialcellproliferationhomeostasisofnumberofcellswithinatissueMAPKcascadenegativeregulationofepithelialcelldifferentiationnegativeregulationofneuronapoptoticprocessneuronapoptoticprocesspositiveregulationofgeneexpressionpositiveregulationofglialcellproliferationpositiveregulationofproteinphosphorylationpositiveregulationofRacproteinsignaltransductionRacproteinsignaltransductionRasproteinsignaltransductionregulationoflong-termneuronalsynapticplasticityregulationofproteinstabilityregulationofsynaptictransmissionGABAergicskeletalmusclecelldifferentiationstriatedmusclecelldifferentiationtypeIpneumocytedifferentiationvisuallearning
Ral guanine nucleotide dissociation stimulator
780
Ral guanine nucleotide dissociation stimulator
780
5.4
60
0.31
GNDSGNDSQ03386Q03386positiveregulationofGTPaseactivityRasproteinsignaltransductionsmallGTPasemediatedsignaltransduction
E3 ubiquitin-protein ligase RNF31
885
E3 ubiquitin-protein ligase RNF31
898
9.9
nan
nan
RNF31RNF31Q96EP0Q96EP0CD40signalingpathwaydefenseresponsetobacteriumnegativeregulationofnecroptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteintargetingtomitochondrionpositiveregulationofxenophagyproteinlinearpolyubiquitinationproteinpolyubiquitinationTcellreceptorsignalingpathway
Neuropilin-1
275
Neuropilin-1
275
8.7
72
0.16
NRP1NRP1O14786O14786actincytoskeletonreorganizationangiogenesisangiogenesisinvolvedincoronaryvascularmorphogenesisanimalorganmorphogenesisarterymorphogenesisaxonextensioninvolvedinaxonguidanceaxonguidanceaxonalfasciculationaxonogenesisinvolvedininnervationbasaldendritearborizationbasaldendritedevelopmentbranchinginvolvedinbloodvesselmorphogenesisbranchiomotorneuronaxonguidancecellmigrationinvolvedinsproutingangiogenesiscell-cellsignalingcellularresponsetohepatocytegrowthfactorstimuluscellularresponsetovascularendothelialgrowthfactorstimuluscommissuralneuronaxonguidancecoronaryarterymorphogenesisdichotomoussubdivisionofterminalunitsinvolvedinsalivaryglandbranchingdorsalrootganglionmorphogenesisendothelialcellchemotaxisendothelialcellmigrationendothelialtipcellfatespecificationfacialnervestructuralorganizationfacioacousticgangliondevelopmentgonadotrophin-releasinghormoneneuronalmigrationtothehypothalamushepatocytegrowthfactorreceptorsignalingpathwayintegrin-mediatedsignalingpathwaymotorneuronmigrationnegativeregulationofaxonextensioninvolvedinaxonguidancenegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofneuronapoptoticprocessnervedevelopmentneuralcrestcellmigrationneuralcrestcellmigrationinvolvedinautonomicnervoussystemdevelopmentneuronmigrationneuropilinsignalingpathwayoticplacodedevelopmentoutflowtractseptummorphogenesisplatelet-derivedgrowthfactorreceptorsignalingpathwaypositivechemotaxispositiveregulationofactincytoskeletonreorganizationpositiveregulationofangiogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcytokineactivitypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffilopodiumassemblypositiveregulationoffocaladhesionassemblypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphorylationpositiveregulationofretinalganglioncellaxonguidancepositiveregulationofsmoothmusclecellmigrationpositiveregulationofstressfiberassemblypositiveregulationofsubstrateadhesion-dependentcellspreadingpostsynapseorganizationproteinlocalizationtoearlyendosomeregulationofCdc42proteinsignaltransductionregulationofretinalganglioncellaxonguidanceregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofvesicle-mediatedtransportrenalarterymorphogenesisresponsetowoundingretinavasculaturemorphogenesisincamera-typeeyeretinalganglioncellaxonguidancesemaphorin-plexinsignalingpathwaysemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesemaphorin-plexinsignalingpathwayinvolvedinneuronprojectionguidancesensoryneuronaxonguidancesignaltransductionsproutingangiogenesissubstrateadhesion-dependentcellspreadingsubstrate-dependentcellmigrationcellextensionsympatheticgangliondevelopmentsympatheticneuronprojectionextensionsympatheticneuronprojectionguidancetoxintransporttrigeminalgangliondevelopmenttrigeminalnervestructuralorganizationvascularendothelialgrowthfactorreceptorsignalingpathwayvasculogenesisVEGF-activatedneuropilinsignalingpathwayVEGF-activatedneuropilinsignalingpathwayinvolvedinaxonguidanceventraltrunkneuralcrestcellmigrationvestibulocochlearnervestructuralorganizationviralentryintohostcell
S-adenosylmethionine decarboxylase proenzyme
148
S-adenosylmethionine decarboxylase proenzyme
148
6.4
nan
nan
DCAMDCAMP17707P17707polyaminemetabolicprocessS-adenosylmethioninaminebiosyntheticprocessS-adenosylmethioninemetabolicprocessspermidinebiosyntheticprocesssperminebiosyntheticprocess
Membrane primary amine oxidase
41
Membrane primary amine oxidase
41
9.6
55
0.19
AOC3AOC3Q16853Q16853aminemetabolicprocesscelladhesioninflammatoryresponsenegativeregulationofprimaryamineoxidaseactivityresponsetoantibiotic
Aldo-keto reductase family 1 member C21
5
Aldo-keto reductase family 1 member C21
5
8.8
63
0.18
AK1CLAK1CLQ91WR5Q91WR5daunorubicinmetabolicprocessdoxorubicinmetabolicprocessprogesteronemetabolicprocessprostaglandinmetabolicprocesssteroidbiosyntheticprocesssteroidmetabolicprocess
Histone-lysine N-methyltransferase SETD7
119
Histone-lysine N-methyltransferase SETD7
119
3.6
74
0.38
SETD7SETD7Q8WTS6Q8WTS6cellularresponsetoDNAdamagestimuluschromatinorganizationheterochromatinorganizationhistonelysinemethylationpeptidyl-lysinedimethylationpeptidyl-lysinemonomethylationregulationofhistoneH3-K9methylationregulationoftranscriptionDNA-templated
Protein mono-ADP-ribosyltransferase PARP14
1618
Protein mono-ADP-ribosyltransferase PARP14
1618
7.5
48
0.28
PAR14PAR14Q460N5Q460N5innateimmuneresponsenegativeregulationofgeneexpressionnegativeregulationofinterferon-gamma-mediatedsignalingpathwaynegativeregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofinterleukin-4-mediatedsignalingpathwaypositiveregulationoftyrosinephosphorylationofSTATproteinproteinADP-ribosylationproteinmono-ADP-ribosylationproteinpoly-ADP-ribosylation
Protection of telomeres protein 1
621
Adrenocortical dysplasia protein homolog
228
9.7
60
0.17
POTE1ACDQ9NUX5Q96AP0DNAduplexunwindingestablishmentofproteinlocalizationtotelomerenegativeregulationoftelomeraseactivitynegativeregulationoftelomeremaintenanceviatelomerasepositiveregulationofDNAhelicaseactivitypositiveregulationofDNAstrandelongationpositiveregulationofhelicaseactivitypositiveregulationoftelomeraseactivitypositiveregulationoftelomeremaintenancepositiveregulationoftelomeremaintenanceviatelomeraseregulationofDNAhelicaseactivityregulationofdouble-strandbreakrepairvianonhomologousendjoiningregulationoftelomeremaintenanceviatelomerasetelomereassemblytelomerecappingtelomeremaintenanceviatelomerasetelomericD-loopdisassemblyembryoniclimbmorphogenesisintracellularproteintransportpositiveregulationofsingle-strandedtelomericDNAbindingprotectionfromnon-homologousendjoiningattelomereproteinlocalizationtochromosometelomericregionsegmentationskeletalsystemdevelopmenttelomeremaintenanceurogenitalsystemdevelopment
C-C chemokine receptor type 5
20
C-C motif chemokine 5
33
7.1
73
0.19
CCR5CCL5P51681P13501calciumiontransportcalcium-mediatedsignalingcellchemotaxiscellsurfacereceptorsignalingpathwaycell-cellsignalingcellulardefenseresponsecellularresponsetolipopolysaccharidechemotaxisdendriticcellchemotaxisGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseMAPKcascadepositiveregulationofcytosoliccalciumionconcentrationreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolsignalingactivationofphospholipaseDactivitycellularcalciumionhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetoviruschemokine-mediatedsignalingpathwayeosinophilchemotaxisexocytosisleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxismonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofinnateimmuneresponsepositiveregulationofmacrophagechemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftranslationalinitiationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofviralgenomereplicationproteinkinaseBsignalingregulationofchronicinflammatoryresponseregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetotoxicsubstanceresponsetovirus
Immunoglobulin heavy constant alpha 1
180
Immunoglobulin heavy constant alpha 1
123
7.4
nan
nan
IGHA1IGHA1P01876P01876adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
C-C chemokine receptor type 5
20
C-C motif chemokine 5
34
9.2
71
0.15
CCR5CCL5P51681P13501calciumiontransportcalcium-mediatedsignalingcellchemotaxiscellsurfacereceptorsignalingpathwaycell-cellsignalingcellulardefenseresponsecellularresponsetolipopolysaccharidechemotaxisdendriticcellchemotaxisGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseMAPKcascadepositiveregulationofcytosoliccalciumionconcentrationreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolsignalingactivationofphospholipaseDactivitycellularcalciumionhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetoviruschemokine-mediatedsignalingpathwayeosinophilchemotaxisexocytosisleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxismonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofinnateimmuneresponsepositiveregulationofmacrophagechemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftranslationalinitiationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofviralgenomereplicationproteinkinaseBsignalingregulationofchronicinflammatoryresponseregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetotoxicsubstanceresponsetovirus
Immunoglobulin kappa constant
107
Immunoglobulin heavy constant gamma 1
103
7.0
nan
nan
IGKCIGHG1P01834P01857adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationretinahomeostasisantibody-dependentcellularcytotoxicitycomplement-dependentcytotoxicity
Endothelin-1
55
Endothelin-1
67
7.0
55
0.26
EDN1EDN1P05305P05305adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayarterysmoothmusclecontractionaxonextensionaxonogenesisinvolvedininnervationbodyfluidsecretionbranchinginvolvedinbloodvesselmorphogenesiscalciumiontransmembranetransportcalcium-mediatedsignalingcanonicalWntsignalingpathwaycardiacneuralcrestcellmigrationinvolvedinoutflowtractmorphogenesiscartilagedevelopmentcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularcalciumionhomeostasiscellularresponsetocalciumioncellularresponsetofattyacidcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetohumanchorionicgonadotropinstimuluscellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoluteinizinghormonestimuluscellularresponsetomineralocorticoidstimuluscellularresponsetoorganicsubstancecellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetotumornecrosisfactorcellularresponsetoxenobioticstimulusdorsal/ventralpatternformationembryonichearttubedevelopmentendothelinreceptorsignalingpathwayendothelinreceptorsignalingpathwayinvolvedinheartprocessepithelialfluidtransportERK1andERK2cascadeGprotein-coupledreceptorsignalingpathwayhistaminesecretionI-kappaBkinase/NF-kappaBsignalinginuteroembryonicdevelopmentinositolphosphate-mediatedsignalingleukocyteactivationmaternalprocessinvolvedinparturitionmeioticcellcycleprocessinvolvedinoocytematurationmembranedepolarizationmiddleearmorphogenesismitochondrionorganizationmulticellularorganismagingnegativeregulationofbloodcoagulationnegativeregulationofgeneexpressionnegativeregulationofhormonesecretionnegativeregulationofnitric-oxidesynthasebiosyntheticprocessnegativeregulationofproteinmetabolicprocessnegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneuralcrestcellfatecommitmentnitricoxidetransportnoradrenergicneurondifferentiationpeptidehormonesecretionpharyngealarcharterymorphogenesisphosphatidylinositol3-kinasesignalingphospholipaseD-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcardiacmusclehypertrophypositiveregulationofcationchannelactivitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellsizepositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellmigrationpositiveregulationofheartratepositiveregulationofhormonesecretionpositiveregulationofJUNkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofmitoticnucleardivisionpositiveregulationofneutrophilchemotaxispositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofodontogenesispositiveregulationofprostaglandinsecretionpositiveregulationofprostaglandin-endoperoxidesynthaseactivitypositiveregulationofrenalsodiumexcretionpositiveregulationofsarcomereorganizationpositiveregulationofsignalingreceptoractivitypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsmoothmusclecontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofurinevolumepositiveregulationofvascularassociatedsmoothmusclecellproliferationprostaglandinbiosyntheticprocessproteinkinaseAsignalingproteinkinaseCdeactivationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteinphosphorylationregulationofglucosetransmembranetransportregulationofpHregulationofsensoryperceptionofpainregulationofsystemicarterialbloodpressurebyendothelinregulationofvasoconstrictionrenalsodiumionabsorptionrespiratorygaseousexchangebyrespiratorysystemresponsetoactivityresponsetoaminoacidresponsetoamphetamineresponsetodexamethasoneresponsetoleptinresponsetolipopolysaccharideresponsetomusclestretchresponsetonicotineresponsetoozoneresponsetoprostaglandinFresponsetosaltresponsetotestosteronerhythmicexcitationsemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesensoryperceptionofpainsuperoxideaniongenerationsympatheticneuronaxonguidancethyroidglanddevelopmenttranscriptionbyRNApolymeraseIIvasoconstrictionveinsmoothmusclecontraction
Rab-like protein 3
41
Rab-like protein 3
41
9.2
69
0.16
RABL3RABL3Q9D4V7Q9D4V7BcelldifferentiationintracellularproteintransportnaturalkillercelldifferentiationproteinstabilizationregulationofproteinlipidationregulationofRasproteinsignaltransductionTcelldifferentiationinthymus
Hepatocyte growth factor
212
Hepatocyte growth factor
289
9.3
81
0.13
HGFHGFQ08048Q08048animalorganregenerationcellchemotaxiscellmorphogenesiscellularresponsetohepatocytegrowthfactorstimulusepithelialcellproliferationhepatocytegrowthfactorreceptorsignalingpathwayliverdevelopmentmyoblastproliferationnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-6productionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofreleaseofcytochromecfrommitochondriapositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofinterleukin-10productionpositiveregulationofMAPKcascadepositiveregulationofmyelinationpositiveregulationofneuronprojectionregenerationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationproteolysisregulationofbranchinginvolvedinsalivaryglandmorphogenesisbymesenchymal-epithelialsignalingregulationofp38MAPKcascaderegulationoftau-proteinkinaseactivityskeletalmusclecellproliferation
Uncharacterized protein
239
IgG H chain
239
5.0
nan
nan
Q8TCD0S6B291Q8TCD0S6B291
C-C chemokine receptor type 5
269
C-C motif chemokine 5
33
8.9
67
0.17
CCR5CCL5P51681P13501calciumiontransportcalcium-mediatedsignalingcellchemotaxiscellsurfacereceptorsignalingpathwaycell-cellsignalingcellulardefenseresponsecellularresponsetolipopolysaccharidechemotaxisdendriticcellchemotaxisGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseMAPKcascadepositiveregulationofcytosoliccalciumionconcentrationreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolsignalingactivationofphospholipaseDactivitycellularcalciumionhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetoviruschemokine-mediatedsignalingpathwayeosinophilchemotaxisexocytosisleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxismonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofinnateimmuneresponsepositiveregulationofmacrophagechemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftranslationalinitiationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofviralgenomereplicationproteinkinaseBsignalingregulationofchronicinflammatoryresponseregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetotoxicsubstanceresponsetovirus
Protein farnesyltransferase subunit beta
299
GTPase KRas
186
4.0
73
0.34
FNTBRASKQ02293P01116lipidmetabolicprocessnegativeregulationofcellpopulationproliferationpositiveregulationofcellcyclepositiveregulationofcellpopulationproliferationpositiveregulationoffibroblastproliferationpositiveregulationofnitric-oxidesynthasebiosyntheticprocessproteinfarnesylationproteinprenylationregulationoffibroblastproliferationresponsetocytokineresponsetoinorganicsubstanceresponsetoorganiccycliccompoundwoundhealingactincytoskeletonorganizationendocrinesignalingepithelialtubebranchinginvolvedinlungmorphogenesisforebrainastrocytedevelopmentglialcellproliferationhomeostasisofnumberofcellswithinatissueMAPKcascadenegativeregulationofepithelialcelldifferentiationnegativeregulationofneuronapoptoticprocessneuronapoptoticprocesspositiveregulationofgeneexpressionpositiveregulationofglialcellproliferationpositiveregulationofproteinphosphorylationpositiveregulationofRacproteinsignaltransductionRacproteinsignaltransductionRasproteinsignaltransductionregulationoflong-termneuronalsynapticplasticityregulationofproteinstabilityregulationofsynaptictransmissionGABAergicskeletalmusclecelldifferentiationstriatedmusclecelldifferentiationtypeIpneumocytedifferentiationvisuallearning
Protein farnesyltransferase subunit beta
95
GTPase KRas
186
7.1
62
0.23
FNTBRASKQ02293P01118lipidmetabolicprocessnegativeregulationofcellpopulationproliferationpositiveregulationofcellcyclepositiveregulationofcellpopulationproliferationpositiveregulationoffibroblastproliferationpositiveregulationofnitric-oxidesynthasebiosyntheticprocessproteinfarnesylationproteinprenylationregulationoffibroblastproliferationresponsetocytokineresponsetoinorganicsubstanceresponsetoorganiccycliccompoundwoundhealingactincytoskeletonorganizationendocrinesignalingepithelialtubebranchinginvolvedinlungmorphogenesisforebrainastrocytedevelopmentglialcellproliferationhomeostasisofnumberofcellswithinatissueMAPKcascadenegativeregulationofepithelialcelldifferentiationnegativeregulationofneuronapoptoticprocessneuronapoptoticprocesspositiveregulationofgeneexpressionpositiveregulationofglialcellproliferationpositiveregulationofproteinphosphorylationpositiveregulationofRacproteinsignaltransductionRacproteinsignaltransductionRasproteinsignaltransductionregulationoflong-termneuronalsynapticplasticityregulationofproteinstabilityregulationofsynaptictransmissionGABAergicskeletalmusclecelldifferentiationstriatedmusclecelldifferentiationtypeIpneumocytedifferentiationvisuallearning
Protein kinase C delta type
280
Protein kinase C delta type
272
9.3
nan
nan
A0A140UHX0A0A140UHX0A0A140UHX0A0A140UHX0apoptoticprocesscellcycleproteinphosphorylation
Interleukin-4
27
Cytokine receptor common subunit gamma
182
8.5
nan
nan
IL4IL2RGP05112P31785activationofJanuskinaseactivityBcellcostimulationBcelldifferentiationcholesterolmetabolicprocessdendriticcelldifferentiationextrinsicapoptoticsignalingpathwayinabsenceofligandimmuneresponseinnateimmuneresponseinmucosamacrophageactivationmicroglialcellactivationmyeloiddendriticcelldifferentiationnegativeregulationofacuteinflammatoryresponsenegativeregulationofapoptoticprocessnegativeregulationofcellularresponsetotransforminggrowthfactorbetastimulusnegativeregulationofchronicinflammatoryresponsenegativeregulationofcomplement-dependentcytotoxicitynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofepithelialcellmigrationnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofinflammatoryresponsenegativeregulationofmacrophageactivationnegativeregulationofneuroinflammatoryresponsenegativeregulationofosteoclastdifferentiationnegativeregulationofT-helper17celldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftumornecrosisfactorproductionneuroinflammatoryresponsepositiveregulationofamyloid-betaclearancepositiveregulationofATPbiosyntheticprocesspositiveregulationofBcellproliferationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellularrespirationpositiveregulationofcold-inducedthermogenesispositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofeosinophilchemotaxispositiveregulationofgeneexpressionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-13productionpositiveregulationofisotypeswitchingtoIgEisotypespositiveregulationofisotypeswitchingtoIgGisotypespositiveregulationofmacroautophagypositiveregulationofmastcelldegranulationpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofmononuclearcellmigrationpositiveregulationofmyoblastfusionpositiveregulationofreceptor-mediatedendocytosispositiveregulationofTcelldifferentiationpositiveregulationofTcellproliferationpositiveregulationofT-helper2cellcytokineproductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofimmuneresponseregulationofisotypeswitchingregulationofphosphorylationTcellactivationT-helper2celldifferentiationtype2immuneresponseCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationcytokine-mediatedsignalingpathwaygeneexpressioninterleukin-15-mediatedsignalingpathwayinterleukin-2-mediatedsignalingpathwayinterleukin-4-mediatedsignalingpathwayinterleukin-7-mediatedsignalingpathwaymatureBcelldifferentiationpositiveregulationofBcelldifferentiationpositiveregulationofCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationpositiveregulationofphagocytosispositiveregulationofTcelldifferentiationinthymussignaltransductionTcelldifferentiationinthymus
Chitotriosidase-1
462
Chitotriosidase-1
420
9.6
65
0.16
CHIT1CHIT1Q13231Q13231chitincatabolicprocessimmuneresponsepolysaccharidecatabolicprocesspolysaccharidedigestionresponsetobacterium
Amyloid-beta precursor protein
133
Amyloid-beta precursor protein
144
5.4
73
0.25
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Interleukin-4
151
Cytokine receptor common subunit gamma
231
8.3
nan
nan
D4HNR6IL2RGD4HNR6P31785BcellactivationimmuneresponseCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationcytokine-mediatedsignalingpathwaygeneexpressioninterleukin-15-mediatedsignalingpathwayinterleukin-2-mediatedsignalingpathwayinterleukin-4-mediatedsignalingpathwayinterleukin-7-mediatedsignalingpathwaymatureBcelldifferentiationpositiveregulationofBcelldifferentiationpositiveregulationofCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationpositiveregulationofgeneexpressionpositiveregulationofphagocytosispositiveregulationofTcelldifferentiationinthymussignaltransductionTcelldifferentiationinthymus
Immunoglobulin kappa constant
107
Ig gamma-1 chain C region, membrane-bound form
102
3.7
nan
nan
IGKCIGH1MP01837P01869adaptiveimmuneresponseBcelldifferentiationBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationantibacterialhumoralresponseantibody-dependentcellularcytotoxicityhumoralimmuneresponsemediatedbycirculatingimmunoglobulinimmunoglobulinmediatedimmuneresponsepositiveregulationofimmuneresponsepositiveregulationofphagocytosispositiveregulationoftypeIhypersensitivitypositiveregulationoftypeIIahypersensitivity
Coagulation factor VII
254
Pancreatic trypsin inhibitor
49
8.7
101
0.11
FA7BPT1P08709P00974activationofbloodcoagulationviaclottingcascadeanimalorganregenerationbloodcoagulationbloodcoagulationextrinsicpathwaybloodcoagulationfibrinclotformationbloodcoagulationintrinsicpathwaycircadianrhythmpositiveregulationofbloodcoagulationpositiveregulationofcellmigrationpositiveregulationofleukocytechemotaxispositiveregulationofplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofpositivechemotaxispositiveregulationofproteinkinaseBsignalingproteinprocessingproteolysisresponseto2378-tetrachlorodibenzodioxineresponsetoanticoagulantresponsetoastaxanthinresponsetocarbondioxideresponsetocholesterolresponsetoestradiolresponsetoestrogenresponsetogenisteinresponsetogrowthhormoneresponsetohypoxiaresponsetoThyroidstimulatinghormoneresponsetothyrotropin-releasinghormoneresponsetothyroxineresponsetovitaminKresponsetowoundingzymogenactivationnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Protein FosB
172
Protein FosB
172
3.5
nan
nan
FOSBFOSBP53539P53539cellularresponsetocalciumioncellularresponsetohormonestimulusfemalepregnancynegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIresponsetocAMPresponsetocorticosteroneresponsetomechanicalstimulusresponsetomorphineresponsetoprogesteroneresponsetoxenobioticstimulustranscriptionbyRNApolymeraseII
Mothers against decapentaplegic homolog 3
338
Zinc finger FYVE domain-containing protein 9
783
5.5
66
0.28
SMAD3ZFYV9P84022O95405activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwayactivinreceptorsignalingpathwayadrenalglanddevelopmentanatomicalstructuremorphogenesisBMPsignalingpathwaycelldifferentiationcell-celljunctionorganizationcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetovirusdevelopmentalgrowthembryoniccranialskeletonmorphogenesisembryonicforegutmorphogenesisembryonicpatternspecificationendodermdevelopmentextrinsicapoptoticsignalingpathwayheartloopingimmuneresponseimmunesystemdevelopmentinuteroembryonicdevelopmentJNKcascadelensfibercelldifferentiationliverdevelopmentmesodermformationnegativeregulationofapoptoticprocessnegativeregulationofcardiacmusclehypertrophyinresponsetostressnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcytosoliccalciumionconcentrationnegativeregulationoffatcelldifferentiationnegativeregulationofinflammatoryresponsenegativeregulationoflungbloodpressurenegativeregulationofosteoblastdifferentiationnegativeregulationofosteoblastproliferationnegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofwoundhealingnodalsignalingpathwayosteoblastdevelopmentparaxialmesodermmorphogenesispericardiumdevelopmentpositiveregulationofalkalinephosphataseactivitypositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofchondrocytedifferentiationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofextracellularmatrixassemblypositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofinterleukin-1betaproductionpositiveregulationofmiRNAtranscriptionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofpositivechemotaxispositiveregulationofproteinimportintonucleuspositiveregulationofstressfiberassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransforminggrowthfactorbeta3productionprimarymiRNAprocessingproteinstabilizationregulationofbindingregulationofepithelialcellproliferationregulationofimmuneresponseregulationofmiRNAtranscriptionregulationofstriatedmuscletissuedevelopmentregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiasignaltransductioninvolvedinregulationofgeneexpressionSMADproteincomplexassemblySMADproteinsignaltransductionsomitogenesisTcellactivationthyroidglanddevelopmenttransdifferentiationtransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentwoundhealingendocytosisendosomaltransport
MORC family CW-type zinc finger protein 3
446
MORC family CW-type zinc finger protein 3
446
3.8
75
0.35
MORC3MORC3Q14149Q14149innateimmuneresponsemaintenanceofproteinlocationinnucleusnegativeregulationoffibroblastproliferationpeptidyl-serinephosphorylationpositiveregulationofcellularsenescencepost-embryonicdevelopmentproteinphosphorylationproteinstabilization
Protein PML
91
Protein PML
91
5.2
65
0.29
PMLPMLP29590P29590activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocessbranchinginvolvedinmammaryglandductmorphogenesiscellfatecommitmentcellularresponsetointerleukin-4cellularresponsetoleukemiainhibitoryfactorcellularsenescencecircadianregulationofgeneexpressioncommon-partnerSMADproteinphosphorylationDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestendoplasmicreticulumcalciumionhomeostasisentrainmentofcircadianclockbyphotoperiodextrinsicapoptoticsignalingpathwayfibroblastmigrationinnateimmuneresponseintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressintrinsicapoptoticsignalingpathwayinresponsetooxidativestressmaintenanceofproteinlocationinnucleusmyeloidcelldifferentiationnegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofinterleukin-1betaproductionnegativeregulationofmitoticcellcyclenegativeregulationoftelomeraseactivitynegativeregulationoftelomeremaintenanceviatelomerasenegativeregulationoftranscriptionDNA-templatednegativeregulationoftranslationinresponsetooxidativestressnegativeregulationofubiquitin-dependentproteincatabolicprocessoncogene-inducedcellsenescencePMLbodyorganizationpositiveregulationofapoptoticprocessinvolvedinmammaryglandinvolutionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationoffibroblastproliferationpositiveregulationofhistonedeacetylationpositiveregulationofpeptidyl-lysineacetylationpositiveregulationofproteinlocalizationtochromosometelomericregionpositiveregulationofsignaltransductionbyp53classmediatorpositiveregulationoftelomeremaintenancepositiveregulationoftranscriptionDNA-templatedproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinimportintonucleusproteinstabilizationproteintargetingprotein-containingcomplexassemblyprotein-containingcomplexlocalizationregulationofcalciumiontransportintocytosolregulationofcelladhesionregulationofcellcycleregulationofcircadianrhythmregulationofdouble-strandbreakrepairregulationoftranscriptionDNA-templatedresponsetocytokineresponsetogammaradiationresponsetohypoxiaresponsetoUVretinoicacidreceptorsignalingpathwaysuppressionofviralreleasebyhosttransforminggrowthfactorbetareceptorsignalingpathway
Pygopus homolog 1
371
Pygopus homolog 1
346
5.2
68
0.28
PYGO1PYGO1Q9Y3Y4Q9Y3Y4canonicalWntsignalingpathwayhematopoieticprogenitorcelldifferentiationkidneydevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationtonucleusspermatidnucleusdifferentiation
SH3 domain-containing protein
246
SH3 domain-containing protein
246
5.2
92
0.21
Q8BX41Q8BX41Q8BX41Q8BX41
Killer cell lectin-like receptor 3
149
Killer cell lectin-like receptor 3
149
5.2
71
0.27
KLRA3KLRA3Q61198Q61198celladhesion
Potassium voltage-gated channel subfamily D member 3
132
Potassium voltage-gated channel subfamily D member 3
110
3.8
68
0.39
KCND3KCND3Q9UK17Q9UK17membranerepolarizationmembranerepolarizationduringcardiacmusclecellactionpotentialmembranerepolarizationduringventricularcardiacmusclecellactionpotentialpotassiumionexportacrossplasmamembranepotassiumiontransmembranetransportpotassiumiontransportproteinhomooligomerizationregulationofheartratebycardiacconductionregulationofiontransmembranetransportventricularcardiacmusclecellmembranerepolarization
Complement C5
1159
Complement C5
1101
6.0
79
0.21
CO5CO5P01031P01031cellsurfacereceptorsignalingpathwaychemotaxiscomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisGprotein-coupledreceptorsignalingpathwayinuteroembryonicdevelopmentinflammatoryresponsenegativeregulationofmacrophagechemotaxispositiveregulationofangiogenesispositiveregulationofchemokineproductionpositiveregulationofimmuneresponsepositiveregulationofvascularendothelialgrowthfactorproduction
cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
178
cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
178
5.4
80
0.23
B7Z5J6B7Z5J6B7Z5J6B7Z5J6smallGTPasemediatedsignaltransduction
Defensin beta 4A
38
Defensin beta 4A
38
5.2
106
0.18
DFB4ADFB4AO15263O15263antifungalinnateimmuneresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellchemotaxischemotaxisdefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponsekillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Tropomyosin alpha-1 chain
190
Tropomyosin alpha-1 chain
190
5.2
56
0.34
1
✔TPM1TPM1P58772P58772
Granzyme H
170
Granzyme H
170
5.5
61
0.3
GRAHGRAHP20718P20718apoptoticprocesscytolysisproteolysis
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
112
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
112
5.2
63
0.31
Q9TTF5Q9TTF5Q9TTF5Q9TTF5metabolicprocess
Histone deacetylase 6
1148
Histone deacetylase 6
1120
5.2
82
0.23
HDAC6HDAC6Q9UBN7Q9UBN7aggresomeassemblyautophagyaxonaltransportofmitochondrioncellularresponsetohydrogenperoxidecellularresponsetomisfoldedproteincellularresponsetotopologicallyincorrectproteinciliumassemblyciliumdisassemblycollateralsproutingdendriticspinemorphogenesishistonedeacetylationHsp90deacetylationintracellularproteintransportlysosomelocalizationnegativeregulationofhydrogenperoxidemetabolicprocessnegativeregulationofmicrotubuledepolymerizationnegativeregulationofoxidoreductaseactivitynegativeregulationofprotein-containingcomplexassemblynegativeregulationofprotein-containingcomplexdisassemblynegativeregulationofproteolysisnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedparkin-mediatedstimulationofmitophagyinresponsetomitochondrialdepolarizationpeptidyl-lysinedeacetylationpolyubiquitinatedmisfoldedproteintransportpositiveregulationofepithelialcellmigrationpositiveregulationofhydrogenperoxide-mediatedprogrammedcelldeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsignalingreceptoractivityproteindeacetylationproteindestabilizationproteinpolyubiquitinationproteinqualitycontrolformisfoldedorincompletelysynthesizedproteinsprotein-containingcomplexdisassemblyregulationofandrogenreceptorsignalingpathwayregulationofautophagyregulationofautophagyofmitochondrionregulationofestablishmentofproteinlocalizationregulationoffatcelldifferentiationregulationofgeneexpressionepigeneticregulationofmacroautophagyregulationofmicrotubule-basedmovementregulationofproteinstabilityresponsetogrowthfactorresponsetomisfoldedproteintubulindeacetylationubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathway
Adenylosuccinate synthetase isozyme 1
281
Adenylosuccinate synthetase isozyme 1
281
5.3
97
0.19
PURA1PURA1P28650P28650"denovoAMPbiosyntheticprocess"AMPbiosyntheticprocessAMPsalvageaspartatemetabolicprocessIMPmetabolicprocesspurinenucleotidemetabolicprocesspurineribonucleosidemonophosphatebiosyntheticprocess
C-C motif chemokine 16
37
C-C motif chemokine 16
37
5.2
74
0.26
CCL16CCL16O15467O15467cellcommunicationcell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
DNA polymerase delta subunit 2
314
DNA polymerase delta subunit 2
314
5.2
76
0.25
DPOD2DPOD2P49005P49005DNAbiosyntheticprocessDNAreplicationDNAstrandelongationinvolvedinDNAreplicationDNA-templatedDNAreplicationerror-pronetranslesionsynthesis
Uromodulin
335
Uromodulin
425
6.0
89
0.19
UROMUROMP07911P07911apoptoticsignalingpathwayautophagycellularcalciumionhomeostasiscellularchlorideionhomeostasiscellulardefenseresponsecellularphosphateionhomeostasiscellularresponsetounfoldedproteincellularsodiumionhomeostasischaperone-mediatedproteinfoldingcitricacidsecretioncollectingductdevelopmentconnectivetissuereplacementcreatininehomeostasisdefenseresponsetoGram-negativebacteriumendoplasmicreticulumorganizationglomerularfiltrationheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesinflammatoryresponsejuxtaglomerularapparatusdevelopmentleukocytecell-celladhesionlipidmetabolicprocessmetanephricascendingthinlimbdevelopmentmetanephricdistalconvolutedtubuledevelopmentmetanephricthickascendinglimbdevelopmentmicturitionmulticellularorganismalresponsetostressnegativeregulationofcellpopulationproliferationneutrophilmigrationorganortissuespecificimmuneresponsepeptidyl-threoninephosphorylationpotassiumionhomeostasisproteinlocalizationtovacuoleproteintransportintoplasmamembraneraftregulationofbloodpressureregulationofproteintransportregulationofurinevolumerenalsodiumionabsorptionrenaluratesaltexcretionrenalwaterhomeostasisresponsetolipopolysaccharideresponsetowaterdeprivationresponsetoxenobioticstimulusRNAsplicingtumornecrosisfactor-mediatedsignalingpathwayubiquitin-dependentERADpathwayuratetransportureatransmembranetransport
Lysozyme C
6
Lysozyme C
127
6.0
69
0.24
LYSCLYSCP11375P11375cytolysisdefenseresponsetobacteriummetabolicprocess
Anaphase-promoting complex subunit 11
51
Anaphase-promoting complex subunit 11
76
3.8
37
0.7
APC11APC11Q9NYG5Q9NYG5anaphase-promotingcomplex-dependentcatabolicprocesscelldivisionmitoticcellcyclepositiveregulationofmitoticmetaphase/anaphasetransitionproteinK11-linkedubiquitinationproteinubiquitinationregulationofmeioticcellcycleregulationofmitoticcellcycleubiquitin-dependentproteincatabolicprocess
MHC class II HLA-DQ-alpha chain
11
MHC class II antigen
111
5.2
91
0.21
Q30066Q67AJ6Q30066Q67AJ6adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Ephrin type-A receptor 1
969
Ephrin type-A receptor 1
969
6.0
58
0.29
EPHA1EPHA1P21709P21709activationofGTPaseactivityangiogenesisaxonguidancecellsurfacereceptorsignalingpathwaynegativeregulationofcellmigrationnegativeregulationofproteinkinaseactivitypeptidyl-tyrosinephosphorylationpositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-matrixadhesionpositiveregulationofkinaseactivitypositiveregulationofstressfiberassemblyproteinautophosphorylationregulationofGTPaseactivitysubstrateadhesion-dependentcellspreadingtransmembranereceptorproteintyrosinekinasesignalingpathway
Regulator of G-protein signaling 16
123
Regulator of G-protein signaling 16
123
3.8
79
0.34
RGS16RGS16O15492O15492Gprotein-coupledreceptorsignalingpathwaynegativeregulationofsignaltransductionpositiveregulationofGTPaseactivityregulationofGprotein-coupledreceptorsignalingpathwayvisualperception
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
236
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
254
6.0
91
0.18
IDH3AIDH3BP50213O43837carbohydratemetabolicprocessisocitratemetabolicprocesstricarboxylicacidcycle2-oxoglutaratemetabolicprocessNADHmetabolicprocess
Activin receptor type-1
395
Activin receptor type-1
395
6.0
51
0.33
ACVR1ACVR1Q04771Q04771activinreceptorsignalingpathwayacuteinflammatoryresponseatrialseptumprimummorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwayBMPsignalingpathwayinvolvedinheartdevelopmentbranchinginvolvedinbloodvesselmorphogenesiscardiacmusclecellfatecommitmentcellularresponsetoBMPstimuluscellularresponsetoglucocorticoidstimuluscellularresponsetogrowthfactorstimulusdeterminationofleft/rightsymmetrydorsal/ventralpatternformationembryonichearttubemorphogenesisendocardialcushioncellfatecommitmentendocardialcushionfusionendocardialcushionmorphogenesisgastrulationwithmouthformingsecondgermcelldevelopmentheartdevelopmentinuteroembryonicdevelopmentmesodermformationmitralvalvemorphogenesisnegativeregulationofactivinreceptorsignalingpathwaynegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofsignaltransductionneuralcrestcellmigrationpathway-restrictedSMADproteinphosphorylationpeptidyl-threoninephosphorylationpharyngealsystemdevelopmentpositiveregulationofbonemineralizationpositiveregulationofcellmigrationpositiveregulationofdeterminationofdorsalidentitypositiveregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationpositiveregulationofosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedproteinphosphorylationregulationofossificationregulationofskeletalmuscletissuedevelopmentsmoothmusclecelldifferentiationtransforminggrowthfactorbetareceptorsignalingpathwayurogenitalsystemdevelopmentventricularseptummorphogenesis
Galectin-1
131
Galectin-1
131
3.8
62
0.43
LEG1LEG1P16045P16045apoptoticprocesscell-celladhesionheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesmyoblastdifferentiationnegativeregulationofcell-substrateadhesionnegativeregulationofneuronprojectiondevelopmentplasmacelldifferentiationpositiveregulationofapoptoticprocesspositiveregulationoferythrocyteaggregationpositiveregulationofinflammatoryresponsepositiveregulationofviralentryintohostcellTcellcostimulation
DNA-binding protein SMUBP-2
191
DNA-binding protein SMUBP-2
191
6.0
45
0.37
SMBP2SMBP2P38935P38935DNAduplexunwindingRNAsecondarystructureunwinding
BLM protein
380
BLM protein
380
5.0
76
0.26
Q3B7X0Q3B7X0Q3B7X0Q3B7X0DNAreplication
Protein fem-1 homolog B
186
Folliculin-interacting protein 1
608
5.1
62
0.32
FEM1BFNIP1Q9Z2G0Q68FD7apoptoticprocessbranchinginvolvedinprostateglandmorphogenesisepithelialcellmaturationepithelialcellmaturationinvolvedinprostateglanddevelopmentproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitinationregulationofDNAdamagecheckpointregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsregulationofubiquitin-proteintransferaseactivityubiquitin-dependentproteincatabolicprocessviatheC-enddegronrulepathwayBcellapoptoticprocesscellularresponsetostarvationimmatureBcelldifferentiationnegativeregulationofcellpopulationproliferationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofTORsignalingnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofBcellapoptoticprocesspositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofTORsignalingregulationofpro-BcelldifferentiationregulationofproteinphosphorylationTORsignaling
STE20/SPS1-related proline-alanine-rich protein kinase
525
STE20/SPS1-related proline-alanine-rich protein kinase
525
5.0
70
0.28
STK39STK39Q9UEW8Q9UEW8cellularchlorideionhomeostasiscellularhypotonicresponsecellularresponsetochemokinecellularresponsetopotassiumionchemokine(C-X-Cmotif)ligand12signalingpathwayinflammatoryresponseintracellularsignaltransductionmacrophageactivationmaintenanceoflenstransparencynegativeregulationofcreatinetransmembranetransporteractivitynegativeregulationofpancreaticjuicesecretionnegativeregulationofpotassiumiontransmembranetransportnegativeregulationofpotassiumiontransmembranetransporteractivitynegativeregulationofsodiumiontransmembranetransporteractivitypeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofiontransmembranetransporteractivitypositiveregulationofp38MAPKcascadepositiveregulationofpotassiumiontransportpositiveregulationofTcellchemotaxisproteinautophosphorylationproteinphosphorylationregulationofbloodpressureregulationofinflammatoryresponseresponsetoaldosteroneresponsetodietaryexcesssignaltransductionsodiumiontransmembranetransport
Histone H3.3
111
Histone H3.3
111
6.0
84
0.2
H33H33P84243P84243cellpopulationproliferationDNAreplication-independentchromatinassemblyembryoimplantationhistoneH3-S10phosphorylationhistoneH3-T3phosphorylationinvolvedinchromosomepassengercomplexlocalizationtokinetochoremalegonaddevelopmentmulticellularorganismgrowthmusclecelldifferentiationnegativeregulationofchromosomecondensationnucleosomeassemblynucleusorganizationoocytematurationosteoblastdifferentiationpericentricheterochromatinassemblypositiveregulationofcellgrowthregulationofcentromerecomplexassemblysinglefertilizationspermatiddevelopmentsubtelomericheterochromatinassemblytelomereorganization
DNA polymerase lambda
300
DNA polymerase lambda
300
5.0
64
0.31
DPOLLDPOLLQ9UGP5Q9UGP5base-excisionrepairgap-fillingDNAbiosyntheticprocessDNAreplicationdouble-strandbreakrepairviahomologousrecombinationdouble-strandbreakrepairvianonhomologousendjoiningnucleotide-excisionrepairsomatichypermutationofimmunoglobulingenes
E3 ubiquitin-protein ligase RNF31
874
E3 ubiquitin-protein ligase RNF31
885
5.0
63
0.32
RNF31RNF31Q96EP0Q96EP0CD40signalingpathwaydefenseresponsetobacteriumnegativeregulationofnecroptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteintargetingtomitochondrionpositiveregulationofxenophagyproteinlinearpolyubiquitinationproteinpolyubiquitinationTcellreceptorsignalingpathway
Killer cell lectin-like receptor 3
149
Killer cell lectin-like receptor 3
154
5.5
76
0.24
KLRA3KLRA3Q61198Q61198celladhesion
cGMP-dependent 3',5'-cyclic phosphodiesterase
393
cGMP-dependent 3',5'-cyclic phosphodiesterase
393
5.5
61
0.3
PDE2APDE2AO00408O00408adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayaortadevelopmentcAMP-mediatedsignalingcellularresponseto2378-tetrachlorodibenzodioxinecellularresponsetocAMPcellularresponsetocGMPcellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimuluscellularresponsetomacrophagecolony-stimulatingfactorstimuluscellularresponsetomechanicalstimuluscellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetoxenobioticstimuluscGMPcatabolicprocesscGMP-mediatedsignalingestablishmentofendothelialbarrierheartvalvedevelopmentmonocytedifferentiationnegativeregulationofcAMP-mediatedsignalingnegativeregulationofcGMP-mediatedsignalingnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofvascularpermeabilitypositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationofvascularpermeabilityregulationofcAMP-mediatedsignalingregulationofcGMP-mediatedsignalingregulationofmitochondrionorganizationsignaltransductionventricularseptumdevelopment
Protein bicaudal D homolog 2
754
Protein bicaudal D homolog 2
754
3.8
50
0.53
BICD2BICD2Q8TD16Q8TD16centrosomelocalizationmicrotubuleanchoringatmicrotubuleorganizingcentermicrotubule-basedmovementminus-end-directedorganelletransportalongmicrotubulemRNAtransportproteinlocalizationtoGolgiapparatusproteinlocalizationtoorganelleproteintransportregulationofmicrotubulecytoskeletonorganizationretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulum
PRKCA-binding protein
44
PRKCA-binding protein
46
5.3
87
0.22
Q6GQQ2Q6GQQ2Q6GQQ2Q6GQQ2monoaminetransportphosphorylationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayregulationofinsulinsecretion
E3 ubiquitin/ISG15 ligase TRIM25
351
E3 ubiquitin/ISG15 ligase TRIM25
351
5.3
54
0.35
TRI25TRI25Q14258Q14258cellularresponsetoleukemiainhibitoryfactorinnateimmuneresponsenegativeregulationofviralentryintohostcellpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivityproteinmonoubiquitinationregulationofproteinlocalizationregulationofviralentryintohostcellresponsetoestrogenresponsetovitaminDsuppressionofviralreleasebyhostubiquitin-dependentERADpathwayubiquitin-dependentproteincatabolicprocessviralreleasefromhostcell
Hepcidin
73
Neutrophil gelatinase-associated lipocalin
195
5.3
81
0.23
HEPCNGALP81172P80188acute-phaseresponseagingantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularironionhomeostasiscellularresponsetobileacidcellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactorcellularresponsetoX-raydefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumestablishmentoflocalizationincellimmuneresponseironiontransmembranetransportkillingofcellsofanotherorganismliverregenerationmacrophageactivationmulticellularorganismalironionhomeostasismyeloidcellhomeostasisnegativeregulationofboneresorptionnegativeregulationofinflammatoryresponsenegativeregulationofintestinalabsorptionnegativeregulationofiontransmembranetransporteractivitynegativeregulationofironexportacrossplasmamembranenegativeregulationofironiontransmembranetransportnegativeregulationofironiontransmembranetransporteractivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofmacrophageactivationpositiveregulationofproteincatabolicprocesspositiveregulationofproteinpolyubiquitinationpositiveregulationofreceptorcatabolicprocesspositiveregulationofreceptorinternalizationpositiveregulationoftranscriptionbyRNApolymeraseIIproteincatabolicprocessreceptorsignalingpathwayviaJAK-STATresponsetoerythropoietinresponsetoethanolresponsetoironionresponsetoironionstarvationresponsetovitaminAresponsetozinciontranscriptionbyRNApolymeraseIIapoptoticprocessinnateimmuneresponsepositiveregulationofcold-inducedthermogenesissequesteringofironionsiderophoretransport
Exportin-1
723
Snurportin-1
356
5.3
68
0.28
XPO1SPN1Q6P5F9O95149mRNAtransportnegativeregulationoftranscriptionbyRNApolymeraseIInucleocytoplasmictransportproteinexportfromnucleusproteinlocalizationtonucleusregulationofcentrosomeduplicationregulationofproteasomalubiquitin-dependentproteincatabolicprocessregulationofproteincatabolicprocessregulationofproteinexportfromnucleusribosomallargesubunitexportfromnucleusribosomalsmallsubunitexportfromnucleusribosomalsubunitexportfromnucleusribosomebiogenesisproteinimportintonucleusRNAimportintonucleussnRNAimportintonucleus
Pygopus homolog 1
346
Pygopus homolog 1
346
5.3
67
0.28
PYGO1PYGO1Q9Y3Y4Q9Y3Y4canonicalWntsignalingpathwayhematopoieticprogenitorcelldifferentiationkidneydevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationtonucleusspermatidnucleusdifferentiation
E3 ubiquitin-protein ligase UHRF2
704
E3 ubiquitin-protein ligase UHRF2
704
4.5
56
0.4
UHRF2UHRF2Q96PU4Q96PU4cellcyclecelldifferentiationmaintenanceofDNAmethylationproteinautoubiquitinationproteinubiquitinationregulationofcellcycle
Transcription initiation factor IIB
223
Transcription initiation factor IIB
223
4.3
92
0.25
TF2BTF2BQ00403Q00403DNA-templatedtranscriptioninitiationpositiveregulationofcorepromoterbindingproteinacetylationRNApolymeraseIIcorecomplexassemblyRNApolymeraseIIpreinitiationcomplexassemblytranscriptionbyRNApolymeraseIItranscriptioninitiationfromRNApolymeraseIIpromotertranscriptionalstartsiteselectionatRNApolymeraseIIpromoterviraltranscription
Progesterone receptor
609
Progesterone receptor
609
5.8
68
0.25
PRGRPRGRP06401P06401cell-cellsignalingglandularepithelialcellmaturationintracellularsteroidhormonereceptorsignalingpathwaylungalveolusdevelopmentnegativeregulationofgeneexpressionovulationfromovarianfollicleparacrinesignalingpositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronereceptorsignalingpathwayregulationofepithelialcellproliferationregulationoftranscriptionbyRNApolymeraseIIsignaltransductiontertiarybranchinginvolvedinmammaryglandductmorphogenesis
Killer cell lectin-like receptor 3
154
Killer cell lectin-like receptor 3
154
5.6
81
0.22
KLRA3KLRA3Q64329Q64329celladhesion
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
38
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
38
5.8
64
0.27
SGTASGTAO43765O43765negativeregulationofER-associatedubiquitin-dependentproteincatabolicprocessnegativeregulationofubiquitin-dependentproteincatabolicprocesspositiveregulationofER-associatedubiquitin-dependentproteincatabolicprocesspost-translationalproteintargetingtoendoplasmicreticulummembranetail-anchoredmembraneproteininsertionintoERmembraneubiquitin-dependentERADpathway
ADP-ribosylation factor-binding protein GGA1
77
ADP-ribosylation factor-binding protein GGA1
34
6.0
83
0.2
GGA1GGA1Q9UJY5Q9UJY5GolgitoplasmamembraneproteintransportGolgitoplasmamembranetransportintracellularproteintransportpositiveregulationofproteincatabolicprocessproteincatabolicprocessproteinlocalizationproteinlocalizationtocellsurfaceproteinlocalizationtociliarymembraneretrogradetransportendosometoGolgitoxintransport
Uromodulin
335
Uromodulin
335
4.8
82
0.26
UROMUROMP07911P07911apoptoticsignalingpathwayautophagycellularcalciumionhomeostasiscellularchlorideionhomeostasiscellulardefenseresponsecellularphosphateionhomeostasiscellularresponsetounfoldedproteincellularsodiumionhomeostasischaperone-mediatedproteinfoldingcitricacidsecretioncollectingductdevelopmentconnectivetissuereplacementcreatininehomeostasisdefenseresponsetoGram-negativebacteriumendoplasmicreticulumorganizationglomerularfiltrationheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesinflammatoryresponsejuxtaglomerularapparatusdevelopmentleukocytecell-celladhesionlipidmetabolicprocessmetanephricascendingthinlimbdevelopmentmetanephricdistalconvolutedtubuledevelopmentmetanephricthickascendinglimbdevelopmentmicturitionmulticellularorganismalresponsetostressnegativeregulationofcellpopulationproliferationneutrophilmigrationorganortissuespecificimmuneresponsepeptidyl-threoninephosphorylationpotassiumionhomeostasisproteinlocalizationtovacuoleproteintransportintoplasmamembraneraftregulationofbloodpressureregulationofproteintransportregulationofurinevolumerenalsodiumionabsorptionrenaluratesaltexcretionrenalwaterhomeostasisresponsetolipopolysaccharideresponsetowaterdeprivationresponsetoxenobioticstimulusRNAsplicingtumornecrosisfactor-mediatedsignalingpathwayubiquitin-dependentERADpathwayuratetransportureatransmembranetransport
Poly(A)-specific ribonuclease PARN
108
Poly(A)-specific ribonuclease PARN
108
4.1
79
0.31
PARNPARNO95453O95453"boxH/ACARNA3-endprocessing"femalegametegenerationmiRNAcatabolicprocessncRNAdeadenylationnuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecaynuclear-transcribedmRNApoly(A)tailshortening"polyadenylation-dependentsnoRNA3-endprocessing"positiveregulationoftelomeraseactivitypositiveregulationoftelomeremaintenanceviatelomeraseregulationoftelomeraseRNAlocalizationtoCajalbodyRNAmodificationRNAphosphodiesterbondhydrolysisexonucleolytictelomeraseRNAstabilization
Thymidylate synthase
174
Thymidylate synthase
174
4.1
88
0.28
TYSYTYSYP45352P45352agingcartilagedevelopmentcircadianrhythmdevelopmentalgrowthdTMPbiosyntheticprocessdTTPbiosyntheticprocessintestinalepithelialcellmaturationliverregenerationmethylationmodulationbyvirusofhostprocessnegativeregulationoftranslationpyrimidinenucleobasemetabolicprocessregulationoftranslationresponsetocytokineresponsetoethanolresponsetofolicacidresponsetoglucocorticoidresponsetoorganiccycliccompoundresponsetoorganophosphorusresponsetoprogesteroneresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulustetrahydrofolateinterconversiontetrahydrofolatemetabolicprocessuracilmetabolicprocess
TNF receptor-associated factor 2
272
TNF receptor-associated factor 2
272
4.8
59
0.36
TRAF2TRAF2Q12933Q12933activationofNF-kappaB-inducingkinaseactivitycellularresponsetonitricoxideinterleukin-17-mediatedsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressmRNAstabilizationnegativeregulationofglialcellapoptoticprocessnegativeregulationofneurondeathpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofI-kappaBphosphorylationpositiveregulationofinterleukin-2productionpositiveregulationofJNKcascadepositiveregulationofJUNkinaseactivitypositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofTcellcytokineproductionpositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayprogrammednecroticcelldeathproteinautoubiquitinationproteincatabolicprocessproteinK63-linkedubiquitinationprotein-containingcomplexassemblyregulationofapoptoticprocessregulationofI-kappaBkinase/NF-kappaBsignalingregulationofimmunoglobulinproductionregulationofprotein-containingcomplexassemblyresponsetoendoplasmicreticulumstresssignaltransductionsignaltransductioninvolvedinregulationofgeneexpressiontumornecrosisfactor-mediatedsignalingpathway
Tumor necrosis factor receptor superfamily, member 25
399
Tumor necrosis factor receptor superfamily, member 25
399
4.8
80
0.26
B1AWN9B1AWN9B1AWN9B1AWN9apoptoticprocesssignaltransduction
Norrin
93
Norrin
69
5.8
74
0.23
NDPNDPQ00604Q00604decidualizationextracellularmatrix-cellsignalingnervoussystemdevelopmentNorrinsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoftranscriptionDNA-templatedretinavasculaturemorphogenesisincamera-typeeyevacuoleorganizationvisualperceptionWntsignalingpathway
Integrin beta-2
33
Integrin beta-2
449
4.8
64
0.33
ITB2ITB2P05107P05107amyloid-betaclearanceapoptoticprocesscelladhesioncelladhesionmediatedbyintegrincellmigrationcell-celladhesioncell-celladhesionviaplasma-membraneadhesionmoleculescell-cellsignalingcell-matrixadhesioncellularresponsetolow-densitylipoproteinparticlestimulusendodermalcelldifferentiationheterotypiccell-celladhesioninflammatoryresponseintegrin-mediatedsignalingpathwayleukocytecell-celladhesionmicroglialcellactivationnegativeregulationofdopaminemetabolicprocessneutrophilchemotaxisneutrophilmigrationphagocytosisengulfmentpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofneurondeathpositiveregulationofneutrophildegranulationpositiveregulationofprostaglandin-Esynthaseactivitypositiveregulationofproteintargetingtomembranepositiveregulationofsuperoxideaniongenerationreceptorclusteringreceptorinternalizationreceptor-mediatedendocytosisregulationofcellshaperegulationofpeptidyl-tyrosinephosphorylation
Integrin beta-2
33
Integrin beta-2
467
4.1
75
0.33
ITB2ITB2P05107P05107amyloid-betaclearanceapoptoticprocesscelladhesioncelladhesionmediatedbyintegrincellmigrationcell-celladhesioncell-celladhesionviaplasma-membraneadhesionmoleculescell-cellsignalingcell-matrixadhesioncellularresponsetolow-densitylipoproteinparticlestimulusendodermalcelldifferentiationheterotypiccell-celladhesioninflammatoryresponseintegrin-mediatedsignalingpathwayleukocytecell-celladhesionmicroglialcellactivationnegativeregulationofdopaminemetabolicprocessneutrophilchemotaxisneutrophilmigrationphagocytosisengulfmentpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofneurondeathpositiveregulationofneutrophildegranulationpositiveregulationofprostaglandin-Esynthaseactivitypositiveregulationofproteintargetingtomembranepositiveregulationofsuperoxideaniongenerationreceptorclusteringreceptorinternalizationreceptor-mediatedendocytosisregulationofcellshaperegulationofpeptidyl-tyrosinephosphorylation
Protein-glutamine gamma-glutamyltransferase 2
554
Protein-glutamine gamma-glutamyltransferase 2
554
4.5
67
0.33
TGM2TGM2P21980P21980apoptoticcellclearancebonedevelopmentbranchinginvolvedinsalivaryglandmorphogenesiscellularresponsetococainecellularresponsetodopaminecellularresponsetoserotoninnegativeregulationofendoplasmicreticulumcalciumionconcentrationpeptidecross-linkingphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofapoptoticprocesspositiveregulationofcelladhesionpositiveregulationofGTPaseactivitypositiveregulationofmitochondrialcalciumionconcentrationpositiveregulationofneurogenesispositiveregulationofsmallGTPasemediatedsignaltransductionproteindeaminationproteinhomooligomerizationproteolysisregulationofapoptoticcellclearanceregulationofapoptoticprocesssalivaryglandcavitation
C-C motif chemokine 4
34
C-C motif chemokine 4
34
4.4
76
0.3
CCL4CCL4P13236P13236celladhesioncell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwayeosinophilchemotaxisestablishmentormaintenanceofcellpolarityGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponselymphocytechemotaxismonocytechemotaxisnegativeregulationbyhostofviraltranscriptionneutrophilchemotaxispositiveregulationofcalciumiontransportpositiveregulationofcalcium-mediatedsignalingpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofnaturalkillercellchemotaxisresponsetotoxicsubstanceresponsetovirussignaltransduction
cGMP-dependent protein kinase 2
240
cGMP-dependent protein kinase 2
240
4.4
53
0.42
KGP2KGP2Q13237Q13237negativeregulationofchloridetransportnegativeregulationofchondrocyteproliferationpeptidyl-serineautophosphorylationproteinlocalizationtoplasmamembraneproteinphosphorylationregulationofchondrocytedifferentiationsignaltransductiontetrahydrobiopterinmetabolicprocess
NAD(+) hydrolase SARM1
649
NAD(+) hydrolase SARM1
649
5.7
76
0.23
SARM1SARM1Q6SZW1Q6SZW1celldifferentiationinnateimmuneresponseNADcatabolicprocessnegativeregulationofMyD88-independenttoll-likereceptorsignalingpathwaynervoussystemdevelopmentpositiveregulationofneurondeathregulationofdendritemorphogenesisregulationofneuronapoptoticprocessregulationofneurondeathresponsetoaxoninjuryresponsetoglucosesignaltransduction
Brain-specific angiogenesis inhibitor 1-associated protein 2
230
Brain-specific angiogenesis inhibitor 1-associated protein 2
202
4.4
67
0.34
BAIP2BAIP2Q9UQB8Q9UQB8actincrosslinkformationactinfilamentbundleassemblyaxonogenesisbraindevelopmentcellularresponsetoepidermalgrowthfactorstimuluscellularresponsetoL-glutamatedendritedevelopmentinsulinreceptorsignalingpathwaymodificationofsynapticstructuremodulatingsynaptictransmissionplasmamembraneorganizationpositiveregulationofactincytoskeletonreorganizationpositiveregulationofactinfilamentpolymerizationpositiveregulationofdendriticspinemorphogenesispositiveregulationofexcitatorypostsynapticpotentialproteinlocalizationtosynapseregulationofactincytoskeletonorganizationregulationofcellshaperegulationofmodificationofpostsynapticactincytoskeletonregulationofsynapticplasticityresponsetobacterium
MHC class II HLA-DQ-alpha chain
11
HLA class II histocompatibility antigen, DQ beta 1 chain
47
4.4
96
0.24
Q30066Q5SU54Q30066Q5SU54adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Tripartite motif-containing 25 variant
365
Tripartite motif-containing 25 variant
365
5.7
56
0.31
Q59GW5Q59GW5Q59GW5Q59GW5
L-lactate dehydrogenase C chain
21
L-lactate dehydrogenase C chain
21
5.7
68
0.26
LDHCLDHCP00342P00342ATPbiosyntheticprocessflagellatedspermmotilitylactatebiosyntheticprocessfrompyruvatelactateoxidationpyruvatemetabolicprocess
Dopamine beta-hydroxylase
528
Dopamine beta-hydroxylase
528
4.4
42
0.55
DOPODOPOP09172P09172behavioralresponsetoethanolbloodvesselremodelingchemicalsynaptictransmissiondopaminecatabolicprocessfearresponseglucosehomeostasishomoiothermyleukocytemediatedimmunityleukocytemigrationlocomotorybehaviormaternalbehaviormemorynorepinephrinebiosyntheticprocessoctopaminebiosyntheticprocesspositiveregulationofcold-inducedthermogenesispositiveregulationofvasoconstrictionregulationofextrinsicapoptoticsignalingpathwayregulationofvascularassociatedsmoothmusclecellproliferationregulationofvascularendothelialcellproliferationresponsetoamphetamineresponsetopainvasoconstrictionvisuallearning
ATP-dependent RNA helicase DDX25
398
ATP-dependent RNA helicase DDX25
398
4.3
81
0.28
DDX25DDX25Q9UHL0Q9UHL0mRNAexportfromnucleuspoly(A)+mRNAexportfromnucleusregulationoftranslationspermatiddevelopment
Synaptonemal complex protein 1
183
Synaptonemal complex protein 1
183
4.2
52
0.46
SYCP1SYCP1Q15431Q15431celldivisionchiasmaassemblyhomologouschromosomepairingatmeiosislateralelementassemblymeioticDNArepairsynthesisproteinhomotetramerizationreciprocalmeioticrecombinationregulationofproteinlocalizationspermDNAcondensationspermatogenesissynaptonemalcomplexassembly
Caspase-4
273
Caspase-4
331
4.2
54
0.44
CASP4CASP4P70343P70343actinfilamentorganizationdefenseresponsetobacteriumdefenseresponsetoGram-positivebacteriumectopicgermcellprogrammedcelldeathinflammatoryresponseinnateimmuneresponsepositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-18-mediatedsignalingpathwaypositiveregulationofmacrophagecytokineproductionproteinautoprocessingpyroptosisregulationofapoptoticprocessregulationofinflammatoryresponse
Copper transport protein ATOX1
15
Copper-transporting ATPase 1
22
4.5
79
0.28
ATOX1ATP7AO00244Q04656cellularcopperionhomeostasiscopperiontransportresponsetooxidativestressbloodvesseldevelopmentbloodvesselremodelingcartilagedevelopmentcatecholaminemetabolicprocesscellularresponsetoaminoacidstimuluscellularresponsetoantibioticcellularresponsetocadmiumioncellularresponsetocobaltioncellularresponsetocopperioncellularresponsetohypoxiacellularresponsetoironioncellularresponsetoleadioncellularresponsetoplatelet-derivedgrowthfactorstimuluscentralnervoussystemneurondevelopmentcerebellarPurkinjecelldifferentiationcollagenfibrilorganizationcopperionexportcopperionhomeostasiscopperionimportdetoxificationofcopperiondopaminemetabolicprocesselasticfiberassemblyelastinbiosyntheticprocessepinephrinemetabolicprocessextracellularmatrixorganizationfemalepregnancyhairfolliclemorphogenesisinuteroembryonicdevelopmentlactationliverdevelopmentlocomotorybehaviorlungalveolusdevelopmentmitochondrionorganizationnegativeregulationofironiontransmembranetransportneuronprojectionmorphogenesisnorepinephrinemetabolicprocesspeptidyl-lysinemodificationpigmentationpositiveregulationofcatalyticactivitypositiveregulationofcellsizepositiveregulationofepithelialcellproliferationpositiveregulationoflamellipodiumassemblypositiveregulationofmelaninbiosyntheticprocesspositiveregulationofresponsetowoundingpositiveregulationoftyrosinaseactivitypositiveregulationofvascularassociatedsmoothmusclecellmigrationpyramidalneurondevelopmentregulationofcytochrome-coxidaseactivityregulationofgeneexpressionregulationofoxidativephosphorylationremovalofsuperoxideradicalsresponsetoiron(III)ionresponsetomanganeseionresponsetozincionserotoninmetabolicprocessskindevelopmentT-helpercelldifferentiationtryptophanmetabolicprocess
Muskelin
180
Muskelin
180
4.5
52
0.43
MKLN1MKLN1Q99PV3Q99PV3actincytoskeletonreorganizationcell-matrixadhesionregulationofcellshaperegulationofreceptorinternalization
MHC class I recognition receptor Ly49I
149
MHC class I recognition receptor Ly49I
149
5.8
71
0.24
Q9JHN9Q9JHN9Q9JHN9Q9JHN9
Dual specificity protein phosphatase 16
81
Dual specificity protein phosphatase 16
81
4.4
68
0.33
DUS16DUS16Q9BY84Q9BY84dephosphorylationMAPKexportfromnucleusnegativeregulationofJUNkinaseactivitynegativeregulationofMAPKcascadeproteindephosphorylation
Transforming acidic coiled-coil-containing protein 3
621
Transforming acidic coiled-coil-containing protein 3
621
4.4
75
0.3
TACC3TACC3Q9JJ11Q9JJ11astralmicrotubuleorganizationcelldivisioncellpopulationproliferationcerebralcortexdevelopmentcytoplasmicsequesteringoftranscriptionfactorhemopoiesisinterkineticnuclearmigrationmetaphase/anaphasetransitionofmitoticcellcyclemicrotubulecytoskeletonorganizationmicrotubulecytoskeletonorganizationinvolvedinmitosismitoticspindleorganizationneurogenesisregulationofcellcycleregulationofmicrotubule-basedprocessregulationofmitoticspindleorganizationresponsetohypoxiastemcellproliferation
MHC class I recognition receptor Ly49I
154
MHC class I recognition receptor Ly49I
154
5.7
78
0.22
Q9JHN9Q9JHN9Q9JHN9Q9JHN9
Palmitoyltransferase ZDHHC20
263
Palmitoyltransferase ZDHHC20
263
4.3
56
0.42
ZDH20ZDH20Q5W0Z9Q5W0Z9peptidyl-L-cysteineS-palmitoylationproteinpalmitoylationproteintargetingtomembrane
Kelch-like ECH-associated protein 1
489
Kelch-like ECH-associated protein 1
434
4.1
76
0.32
KEAP1KEAP1Q14145Q14145cellularresponsetointerleukin-4cellularresponsetooxidativestresscytoplasmicsequesteringoftranscriptionfactorinuteroembryonicdevelopmentnegativeregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteinubiquitinationregulationofautophagyregulationofepidermalcelldifferentiationubiquitin-dependentproteincatabolicprocess
Inositol-trisphosphate 3-kinase A
342
Inositol-trisphosphate 3-kinase A
342
4.7
60
0.35
IP3KAIP3KAP23677P23677actincytoskeletonorganizationcellularresponsetocalciumiondendriticspinemaintenanceinositolmetabolicprocessinositolphosphatebiosyntheticprocessphosphatidylinositolphosphatebiosyntheticprocessphosphorylationpositiveregulationofdendriticspinemorphogenesisregulationofsynapticplasticityresponsetocalciumionsignaltransduction
Kinetochore-associated protein DSN1 homolog
191
Kinetochore-associated protein NSL1 homolog
40
5.3
70
0.27
DSN1NSL1Q9H410Q96IY1celldivisionmitoticsisterchromatidsegregation
Protein fem-1 homolog B
186
Folliculin-interacting protein 1
610
3.8
69
0.38
FEM1BFNIP1Q9Z2G0Q68FD7apoptoticprocessbranchinginvolvedinprostateglandmorphogenesisepithelialcellmaturationepithelialcellmaturationinvolvedinprostateglanddevelopmentproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitinationregulationofDNAdamagecheckpointregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsregulationofubiquitin-proteintransferaseactivityubiquitin-dependentproteincatabolicprocessviatheC-enddegronrulepathwayBcellapoptoticprocesscellularresponsetostarvationimmatureBcelldifferentiationnegativeregulationofcellpopulationproliferationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofTORsignalingnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofBcellapoptoticprocesspositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofTORsignalingregulationofpro-BcelldifferentiationregulationofproteinphosphorylationTORsignaling
Ubiquitin-conjugating enzyme E2 S
118
Ubiquitin-conjugating enzyme E2 S
118
3.8
80
0.33
UBE2SUBE2SQ16763Q16763anaphase-promotingcomplex-dependentcatabolicprocesscelldivisionexitfrommitosisfreeubiquitinchainpolymerizationpositiveregulationofubiquitinproteinligaseactivityproteinK11-linkedubiquitinationproteinK27-linkedubiquitinationproteinK29-linkedubiquitinationproteinK6-linkedubiquitinationproteinK63-linkedubiquitinationproteinmodificationprocessproteinpolyubiquitinationubiquitin-dependentproteincatabolicprocess
Secreted frizzled-related protein 3
108
Secreted frizzled-related protein 3
108
6.0
78
0.21
SFRP3SFRP3P97401P97401canonicalWntsignalingpathwaycochleamorphogenesisconvergentextensioninvolvedinorganogenesisepithelialcelldevelopmenthepatocytedifferentiationinnerearmorphogenesisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcartilagedevelopmentnegativeregulationofcelldevelopmentnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofhepatocytedifferentiationnegativeregulationofWntsignalingpathwayneuralcrestcelldifferentiationpositiveregulationofapoptoticprocesspositiveregulationoffatcelldifferentiationsomitedevelopment
Ig gamma-2A chain C region, A allele
107
Ig gamma-2A chain C region, A allele
110
5.2
31
0.61
GCAAGCAAP01863P01863BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationresponsetobacterium
cGMP-dependent 3',5'-cyclic phosphodiesterase
234
cGMP-dependent 3',5'-cyclic phosphodiesterase
234
5.7
81
0.22
PDE2APDE2AO00408O00408adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayaortadevelopmentcAMP-mediatedsignalingcellularresponseto2378-tetrachlorodibenzodioxinecellularresponsetocAMPcellularresponsetocGMPcellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimuluscellularresponsetomacrophagecolony-stimulatingfactorstimuluscellularresponsetomechanicalstimuluscellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetoxenobioticstimuluscGMPcatabolicprocesscGMP-mediatedsignalingestablishmentofendothelialbarrierheartvalvedevelopmentmonocytedifferentiationnegativeregulationofcAMP-mediatedsignalingnegativeregulationofcGMP-mediatedsignalingnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofvascularpermeabilitypositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationofvascularpermeabilityregulationofcAMP-mediatedsignalingregulationofcGMP-mediatedsignalingregulationofmitochondrionorganizationsignaltransductionventricularseptumdevelopment
Zinc finger MYND domain-containing protein 11
528
Zinc finger MYND domain-containing protein 11
528
4.2
48
0.5
ZMY11ZMY11Q15326Q15326cellcyclechromatinorganizationdefenseresponsetovirusnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofJNKcascadenegativeregulationoftranscriptionDNA-templatedregulationofsignaltransductionregulationoftranscriptionelongationfromRNApolymeraseIIpromoter
C-C motif chemokine 13
34
C-C motif chemokine 13
34
4.7
74
0.29
CCL13CCL13Q99616Q99616antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytoskeletonorganizationeosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivityregulationofcellshapesignaltransduction
Serine/threonine-protein kinase 32A
346
Serine/threonine-protein kinase 32A
346
4.2
48
0.5
ST32AST32AQ8WU08Q8WU08intracellularsignaltransductionpeptidyl-serinephosphorylation
Transforming growth factor beta-1 proprotein
225
Transforming growth factor beta-1 proprotein
225
5.8
65
0.26
TGFB1TGFB1P07200P07200adaptiveimmuneresponsebasedonsomaticrecombinationofimmunereceptorsbuiltfromimmunoglobulinsuperfamilydomainsaorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaybranchelongationinvolvedinmammaryglandductbranchingbronchioledevelopmentcellmigrationcellmorphogenesiscell-celljunctionorganizationcellularcalciumionhomeostasiscellularresponsetoionizingradiationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetoviruschondrocytedifferentiationcolumnar/cuboidalepithelialcellmaturationcommon-partnerSMADproteinphosphorylationembryonicliverdevelopmentenamelmineralizationendodermdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialcellproliferationepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayfacemorphogenesisgeneexpressiongermcellmigrationhematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponseLangerhanscelldifferentiationlensfibercelldifferentiationlipopolysaccharide-mediatedsignalingpathwaylungalveolusdevelopmentlymphnodedevelopmentmammaryglandbranchinginvolvedinthelarcheMAPKcascademembraneproteinintracellulardomainproteolysismusclecellcellularhomeostasisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofepithelialcellproliferationnegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofinterleukin-17productionnegativeregulationofmacrophagecytokineproductionnegativeregulationofmyoblastdifferentiationnegativeregulationofossificationnegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationofTcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneuraltubeclosureNotchsignalingpathwayoligodendrocytedevelopmentossificationinvolvedinboneremodelingosteoclastdifferentiationpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocessphospholipidhomeostasispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofhistoneacetylationpositiveregulationofhistonedeacetylationpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofodontogenesispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorclusteringpositiveregulationofregulatoryTcelldifferentiationpositiveregulationofSMADproteinsignaltransductionpositiveregulationofstemcellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofactincytoskeletonreorganizationregulationofbindingregulationofbranchinginvolvedinmammaryglandductmorphogenesisregulationofcartilagedevelopmentregulationofcellpopulationproliferationregulationofDNAbindingregulationofinterleukin-23productionregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofsodiumiontransportregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulatoryTcelldifferentiationresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductionstemcellproliferationsurfactanthomeostasisTcellhomeostasisTcellproliferationtoleranceinductiontoselfantigentransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmenturetericbuddevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
Chymotrypsinogen A
58
Pancreatic trypsin inhibitor
49
8.6
nan
nan
CTRABPT1P00766P00974digestionproteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Defensin alpha 5
93
Defensin alpha 5
82
8.5
64
0.18
DEF5DEF5Q01523Q01523antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismpositiveregulationofinterleukin-8productionpositiveregulationofmembranepermeabilityproteinhomotetramerization
Hepatocyte growth factor
129
Hepatocyte growth factor
212
9.9
88
0.12
HGFHGFQ08048Q08048animalorganregenerationcellchemotaxiscellmorphogenesiscellularresponsetohepatocytegrowthfactorstimulusepithelialcellproliferationhepatocytegrowthfactorreceptorsignalingpathwayliverdevelopmentmyoblastproliferationnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-6productionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofreleaseofcytochromecfrommitochondriapositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofinterleukin-10productionpositiveregulationofMAPKcascadepositiveregulationofmyelinationpositiveregulationofneuronprojectionregenerationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationproteolysisregulationofbranchinginvolvedinsalivaryglandmorphogenesisbymesenchymal-epithelialsignalingregulationofp38MAPKcascaderegulationoftau-proteinkinaseactivityskeletalmusclecellproliferation
Chitotriosidase-1
440
Chitotriosidase-1
462
8.7
79
0.15
CHIT1CHIT1Q13231Q13231chitincatabolicprocessimmuneresponsepolysaccharidecatabolicprocesspolysaccharidedigestionresponsetobacterium
Aphrodisin
54
Aphrodisin
58
3.1
45
0.72
APHRAPHRP09465P09465
D(3) dopamine receptor
122
D(3) dopamine receptor
166
6.1
92
0.18
DRD3DRD3P35462P35462acidsecretionadenylatecyclase-activatingadrenergicreceptorsignalingpathwayadenylatecyclase-activatingdopaminereceptorsignalingpathwayadenylatecyclase-inhibitingdopaminereceptorsignalingpathwayarachidonicacidsecretionautophagybehavioralresponsetococainecellularcalciumionhomeostasiscircadianregulationofgeneexpressiondopaminemetabolicprocessGprotein-coupledreceptorinternalizationGprotein-coupledreceptorsignalingpathwaygastricemptyinglearninglearningormemorylocomotorybehaviormusculoskeletalmovementspinalreflexactionnegativeregulationofadenylatecyclaseactivitynegativeregulationofapoptoticprocessnegativeregulationofbloodpressurenegativeregulationofcytosoliccalciumionconcentrationnegativeregulationofoligodendrocytedifferentiationnegativeregulationofproteinkinaseBsignalingnegativeregulationofproteinsecretionnegativeregulationofsodiumnegativeregulationofsynaptictransmissionglutamatergicnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofvoltage-gatedcalciumchannelactivityphospholipaseC-activatingdopaminereceptorsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofcytokinesispositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofdopaminereceptorsignalingpathwaypositiveregulationofmitoticnucleardivisionpositiveregulationofrenalsodiumexcretionpositiveregulationoftranscriptionbyRNApolymeraseIIprepulseinhibitionregulationofcircadiansleep/wakecyclesleepregulationofdopaminesecretionregulationofdopamineuptakeinvolvedinsynaptictransmissionregulationoflocomotioninvolvedinlocomotorybehaviorregulationofpostsynapticneurotransmitterreceptorinternalizationregulationofpotassiumiontransportresponsetococaineresponsetohistamineresponsetomorphineresponsetoxenobioticstimulussocialbehaviorvisuallearning
Interleukin-4
151
Cytokine receptor common subunit gamma
182
8.9
57
0.2
IL4IL2RGP05112P31785activationofJanuskinaseactivityBcellcostimulationBcelldifferentiationcholesterolmetabolicprocessdendriticcelldifferentiationextrinsicapoptoticsignalingpathwayinabsenceofligandimmuneresponseinnateimmuneresponseinmucosamacrophageactivationmicroglialcellactivationmyeloiddendriticcelldifferentiationnegativeregulationofacuteinflammatoryresponsenegativeregulationofapoptoticprocessnegativeregulationofcellularresponsetotransforminggrowthfactorbetastimulusnegativeregulationofchronicinflammatoryresponsenegativeregulationofcomplement-dependentcytotoxicitynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofepithelialcellmigrationnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofinflammatoryresponsenegativeregulationofmacrophageactivationnegativeregulationofneuroinflammatoryresponsenegativeregulationofosteoclastdifferentiationnegativeregulationofT-helper17celldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftumornecrosisfactorproductionneuroinflammatoryresponsepositiveregulationofamyloid-betaclearancepositiveregulationofATPbiosyntheticprocesspositiveregulationofBcellproliferationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellularrespirationpositiveregulationofcold-inducedthermogenesispositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofeosinophilchemotaxispositiveregulationofgeneexpressionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-13productionpositiveregulationofisotypeswitchingtoIgEisotypespositiveregulationofisotypeswitchingtoIgGisotypespositiveregulationofmacroautophagypositiveregulationofmastcelldegranulationpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofmononuclearcellmigrationpositiveregulationofmyoblastfusionpositiveregulationofreceptor-mediatedendocytosispositiveregulationofTcelldifferentiationpositiveregulationofTcellproliferationpositiveregulationofT-helper2cellcytokineproductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofimmuneresponseregulationofisotypeswitchingregulationofphosphorylationTcellactivationT-helper2celldifferentiationtype2immuneresponseCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationcytokine-mediatedsignalingpathwaygeneexpressioninterleukin-15-mediatedsignalingpathwayinterleukin-2-mediatedsignalingpathwayinterleukin-4-mediatedsignalingpathwayinterleukin-7-mediatedsignalingpathwaymatureBcelldifferentiationpositiveregulationofBcelldifferentiationpositiveregulationofCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationpositiveregulationofphagocytosispositiveregulationofTcelldifferentiationinthymussignaltransductionTcelldifferentiationinthymus
Growth/differentiation factor 5
433
Growth/differentiation factor 5
465
8.3
78
0.15
GDF5GDF5P43026P43026BMPsignalingpathwaycell-cellsignalingchondroblastdifferentiationchondrocytedifferentiationembryoniclimbmorphogenesisforelimbmorphogenesishindlimbmorphogenesismesenchymalcellapoptoticprocessnegativeregulationofchondrocytedifferentiationnegativeregulationofepithelialcellproliferationnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofneuronapoptoticprocessossificationinvolvedinboneremodelingpositiveregulationofBMPsignalingpathwaypositiveregulationofchondrocytedifferentiationpositiveregulationofneurondifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationregulationofmulticellularorganismgrowthregulationofSMADproteinsignaltransductionresponsetomechanicalstimulusSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Cryptochrome-1
414
Period circadian protein homolog 2
1210
3.3
74
0.41
CRY1PER2P97784O54943circadianregulationofgeneexpressioncircadianrhythmDNAdamageinducedproteinphosphorylationentrainmentofcircadianclockbyphotoperiodgluconeogenesisglucosehomeostasislipidstoragenegativeregulationofcircadianrhythmnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofglucocorticoidsecretionnegativeregulationofgluconeogenesisnegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofproteinubiquitinationregulationofcircadianrhythmregulationofDNAdamagecheckpointresponsetoactivityresponsetoglucagonresponsetoinsulinresponsetolightstimuluscircadianregulationoftranslationfattyacidmetabolicprocessglycogenbiosyntheticprocesshistoneH3deacetylationlactatebiosyntheticprocessnegativeregulationofDNA-templatedtranscriptionterminationnegativeregulationoffatcellproliferationnegativeregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationofcold-inducedthermogenesisregulationofcellcycleregulationofglutamateuptakeinvolvedintransmissionofnerveimpulseregulationofinsulinsecretionregulationofneurogenesisregulationofvasoconstrictionresponsetoischemiawhitefatcelldifferentiation
Endothelin-1
63
Endothelin-1
55
9.1
53
0.21
EDN1EDN1P05305P05305adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayarterysmoothmusclecontractionaxonextensionaxonogenesisinvolvedininnervationbodyfluidsecretionbranchinginvolvedinbloodvesselmorphogenesiscalciumiontransmembranetransportcalcium-mediatedsignalingcanonicalWntsignalingpathwaycardiacneuralcrestcellmigrationinvolvedinoutflowtractmorphogenesiscartilagedevelopmentcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularcalciumionhomeostasiscellularresponsetocalciumioncellularresponsetofattyacidcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetohumanchorionicgonadotropinstimuluscellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoluteinizinghormonestimuluscellularresponsetomineralocorticoidstimuluscellularresponsetoorganicsubstancecellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetotumornecrosisfactorcellularresponsetoxenobioticstimulusdorsal/ventralpatternformationembryonichearttubedevelopmentendothelinreceptorsignalingpathwayendothelinreceptorsignalingpathwayinvolvedinheartprocessepithelialfluidtransportERK1andERK2cascadeGprotein-coupledreceptorsignalingpathwayhistaminesecretionI-kappaBkinase/NF-kappaBsignalinginuteroembryonicdevelopmentinositolphosphate-mediatedsignalingleukocyteactivationmaternalprocessinvolvedinparturitionmeioticcellcycleprocessinvolvedinoocytematurationmembranedepolarizationmiddleearmorphogenesismitochondrionorganizationmulticellularorganismagingnegativeregulationofbloodcoagulationnegativeregulationofgeneexpressionnegativeregulationofhormonesecretionnegativeregulationofnitric-oxidesynthasebiosyntheticprocessnegativeregulationofproteinmetabolicprocessnegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneuralcrestcellfatecommitmentnitricoxidetransportnoradrenergicneurondifferentiationpeptidehormonesecretionpharyngealarcharterymorphogenesisphosphatidylinositol3-kinasesignalingphospholipaseD-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcardiacmusclehypertrophypositiveregulationofcationchannelactivitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellsizepositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellmigrationpositiveregulationofheartratepositiveregulationofhormonesecretionpositiveregulationofJUNkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofmitoticnucleardivisionpositiveregulationofneutrophilchemotaxispositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofodontogenesispositiveregulationofprostaglandinsecretionpositiveregulationofprostaglandin-endoperoxidesynthaseactivitypositiveregulationofrenalsodiumexcretionpositiveregulationofsarcomereorganizationpositiveregulationofsignalingreceptoractivitypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsmoothmusclecontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofurinevolumepositiveregulationofvascularassociatedsmoothmusclecellproliferationprostaglandinbiosyntheticprocessproteinkinaseAsignalingproteinkinaseCdeactivationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteinphosphorylationregulationofglucosetransmembranetransportregulationofpHregulationofsensoryperceptionofpainregulationofsystemicarterialbloodpressurebyendothelinregulationofvasoconstrictionrenalsodiumionabsorptionrespiratorygaseousexchangebyrespiratorysystemresponsetoactivityresponsetoaminoacidresponsetoamphetamineresponsetodexamethasoneresponsetoleptinresponsetolipopolysaccharideresponsetomusclestretchresponsetonicotineresponsetoozoneresponsetoprostaglandinFresponsetosaltresponsetotestosteronerhythmicexcitationsemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesensoryperceptionofpainsuperoxideaniongenerationsympatheticneuronaxonguidancethyroidglanddevelopmenttranscriptionbyRNApolymeraseIIvasoconstrictionveinsmoothmusclecontraction
Interleukin-4
151
Interleukin-13 receptor subunit alpha-1
257
9.1
50
0.22
IL4I13R1P05112P78552activationofJanuskinaseactivityBcellcostimulationBcelldifferentiationcholesterolmetabolicprocessdendriticcelldifferentiationextrinsicapoptoticsignalingpathwayinabsenceofligandimmuneresponseinnateimmuneresponseinmucosamacrophageactivationmicroglialcellactivationmyeloiddendriticcelldifferentiationnegativeregulationofacuteinflammatoryresponsenegativeregulationofapoptoticprocessnegativeregulationofcellularresponsetotransforminggrowthfactorbetastimulusnegativeregulationofchronicinflammatoryresponsenegativeregulationofcomplement-dependentcytotoxicitynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofepithelialcellmigrationnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofinflammatoryresponsenegativeregulationofmacrophageactivationnegativeregulationofneuroinflammatoryresponsenegativeregulationofosteoclastdifferentiationnegativeregulationofT-helper17celldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftumornecrosisfactorproductionneuroinflammatoryresponsepositiveregulationofamyloid-betaclearancepositiveregulationofATPbiosyntheticprocesspositiveregulationofBcellproliferationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellularrespirationpositiveregulationofcold-inducedthermogenesispositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofeosinophilchemotaxispositiveregulationofgeneexpressionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-13productionpositiveregulationofisotypeswitchingtoIgEisotypespositiveregulationofisotypeswitchingtoIgGisotypespositiveregulationofmacroautophagypositiveregulationofmastcelldegranulationpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofmononuclearcellmigrationpositiveregulationofmyoblastfusionpositiveregulationofreceptor-mediatedendocytosispositiveregulationofTcelldifferentiationpositiveregulationofTcellproliferationpositiveregulationofT-helper2cellcytokineproductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofimmuneresponseregulationofisotypeswitchingregulationofphosphorylationTcellactivationT-helper2celldifferentiationtype2immuneresponsecellsurfacereceptorsignalingpathwaycytokine-mediatedsignalingpathwayoncostatin-M-mediatedsignalingpathway
Acyloxyacyl hydrolase
40
Acyloxyacyl hydrolase
453
8.0
69
0.18
AOAHAOAHO18823O18823fattyacidmetabolicprocesslipopolysaccharidecatabolicprocess
Estrogen receptor
227
Estrogen receptor
227
5.9
65
0.26
ESR1ESR1P03372P03372androgenmetabolicprocessantralovarianfolliclegrowthcellularresponsetoestradiolstimuluscellularresponsetoestrogenstimuluschromatinremodelingepithelialcelldevelopmentepithelialcellproliferationinvolvedinmammaryglandductelongationfibroblastproliferationintracellularestrogenreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaymalegonaddevelopmentmammaryglandalveolusdevelopmentmammaryglandbranchinginvolvedinpregnancynegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofgeneexpressionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofmiRNAmaturationnegativeregulationoftranscriptionbyRNApolymeraseIIphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoffibroblastproliferationpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofphospholipaseCactivitypositiveregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprostateepithelialcordarborizationinvolvedinprostateglandularacinusmorphogenesisprostateepithelialcordelongationproteinlocalizationtochromatinregulationofbranchinginvolvedinprostateglandmorphogenesisregulationofepithelialcellapoptoticprocessregulationofinflammatoryresponseregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetoestradiolresponsetoestrogensignaltransductionstemcelldifferentiationtranscriptionbyRNApolymeraseIIuterusdevelopmentvaginadevelopment
Proprotein convertase subtilisin/kexin type 9
378
Low-density lipoprotein receptor
325
8.8
75
0.15
PCSK9LDLRQ8NBP7P01130apoptoticprocesscellularresponsetoinsulinstimuluscellularresponsetostarvationcholesterolhomeostasischolesterolmetabolicprocesskidneydevelopmentlipoproteinmetabolicprocessliverdevelopmentlow-densitylipoproteinparticlereceptorcatabolicprocesslysosomaltransportnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationoflow-densitylipoproteinparticlereceptorbindingnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofreceptorinternalizationnegativeregulationofreceptorrecyclingnegativeregulationofreceptor-mediatedendocytosisinvolvedincholesteroltransportnegativeregulationofsodiumiontransmembranetransporteractivityneurogenesisneurondifferentiationphospholipidmetabolicprocesspositiveregulationoflow-densitylipoproteinparticlereceptorcatabolicprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofreceptorinternalizationproteinautoprocessingregulationofneuronapoptoticprocessregulationofsignalingreceptoractivitytriglyceridemetabolicprocessamyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessarterymorphogenesiscellularresponsetofattyacidcellularresponsetolow-densitylipoproteinparticlestimuluscholesterolimportcholesteroltransportendocytosishigh-densitylipoproteinparticleclearanceintestinalcholesterolabsorptionlipidmetabolicprocesslipoproteincatabolicprocesslong-termmemorylow-densitylipoproteinparticleclearancenegativeregulationofamyloidfibrilformationnegativeregulationofastrocyteactivationnegativeregulationofgeneexpressionnegativeregulationofmicroglialcellactivationnegativeregulationofproteinmetabolicprocessphagocytosisphospholipidtransportplasmalipoproteinparticleclearancepositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationoflysosomalproteincatabolicprocesspositiveregulationoftriglyceridebiosyntheticprocessreceptor-mediatedendocytosisreceptor-mediatedendocytosisinvolvedincholesteroltransportregulationofcholesterolmetabolicprocessregulationofphosphatidylcholinecatabolicprocessregulationofproteinmetabolicprocessresponsetocaloricrestriction
Interleukin-6 receptor subunit alpha
176
Interleukin-6 receptor subunit alpha
121
7.8
70
0.18
IL6RAIL6RAP08887P08887acute-phaseresponseciliaryneurotrophicfactor-mediatedsignalingpathwaycytokine-mediatedsignalingpathwaydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumendocrinepancreasdevelopmentextrinsicapoptoticsignalingpathwayhepaticimmuneresponseinterleukin-6-mediatedsignalingpathwaymonocytechemotaxisnegativeregulationofcollagenbiosyntheticprocessnegativeregulationofinterleukin-8productionneutrophilmediatedimmunitypositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcellpopulationproliferationpositiveregulationofchemokineproductionpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofinterleukin-6productionpositiveregulationofleukocytechemotaxispositiveregulationofMAPKcascadepositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofplateletaggregationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinresponsetocytokineT-helper17celllineagecommitmentvascularendothelialgrowthfactorproduction
C-C chemokine receptor type 5
20
C-C motif chemokine 5
73
9.2
68
0.16
CCR5CCL5P51681P13501calciumiontransportcalcium-mediatedsignalingcellchemotaxiscellsurfacereceptorsignalingpathwaycell-cellsignalingcellulardefenseresponsecellularresponsetolipopolysaccharidechemotaxisdendriticcellchemotaxisGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseMAPKcascadepositiveregulationofcytosoliccalciumionconcentrationreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolsignalingactivationofphospholipaseDactivitycellularcalciumionhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetoviruschemokine-mediatedsignalingpathwayeosinophilchemotaxisexocytosisleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxismonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofinnateimmuneresponsepositiveregulationofmacrophagechemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftranslationalinitiationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofviralgenomereplicationproteinkinaseBsignalingregulationofchronicinflammatoryresponseregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetotoxicsubstanceresponsetovirus
Norrin
93
Norrin
128
8.5
70
0.17
NDPNDPQ00604Q00604decidualizationextracellularmatrix-cellsignalingnervoussystemdevelopmentNorrinsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoftranscriptionDNA-templatedretinavasculaturemorphogenesisincamera-typeeyevacuoleorganizationvisualperceptionWntsignalingpathway
Fibrinogen gamma-B chain
33
Fibrinogen gamma-B chain
33
7.8
51
0.25
FIBGFIBGP12799P12799bloodcoagulationfibrinclotformationcell-matrixadhesionplateletaggregationproteinpolymerization
Uncharacterized protein
239
Immunoglobulin gamma-1 heavy chain
222
3.7
nan
nan
Q8TCD0IGG1Q8TCD0P0DOX5adaptiveimmuneresponse
Neutrophil defensin 3
94
Neutrophil defensin 3
83
8.5
nan
nan
DEF3DEF3P59666P59666antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetovirusinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Glial cell line-derived neurotrophic factor
178
Glial cell line-derived neurotrophic factor
179
9.9
73
0.14
GDNFGDNFQ07731Q07731branchinginvolvedinuretericbudmorphogenesiscellpopulationproliferationcellularresponsetodexamethasonestimuluscommissuralneuronaxonguidancedorsalspinalcorddevelopmentembryonicorgandevelopmententericnervoussystemdevelopmentmalegonaddevelopmentmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesismetanephrosdevelopmentmidbraindevelopmentmRNAstabilizationnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofneuronapoptoticprocessnervoussystemdevelopmentneuralcrestcellmigrationneurondifferentiationneuronprojectiondevelopmentorganinductionperipheralnervoussystemdevelopmentperistalsispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesispositiveregulationofmonooxygenaseactivitypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofuretericbudformationpostganglionicparasympatheticfiberdevelopmentpostsynapticmembraneorganizationregulationofdopamineuptakeinvolvedinsynaptictransmissionregulationofgeneexpressionregulationofmorphogenesisofabranchingstructureregulationofsemaphorin-plexinsignalingpathwayregulationofuretericbudformationresponsetowoundingretinadevelopmentincamera-typeeyesympatheticnervoussystemdevelopmenturetericbuddevelopmenturetericbudformation
Cryptochrome-1
363
Period circadian protein homolog 2
1210
10.0
77
0.13
CRY1PER2P97784O54943circadianregulationofgeneexpressioncircadianrhythmDNAdamageinducedproteinphosphorylationentrainmentofcircadianclockbyphotoperiodgluconeogenesisglucosehomeostasislipidstoragenegativeregulationofcircadianrhythmnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofglucocorticoidsecretionnegativeregulationofgluconeogenesisnegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofproteinubiquitinationregulationofcircadianrhythmregulationofDNAdamagecheckpointresponsetoactivityresponsetoglucagonresponsetoinsulinresponsetolightstimuluscircadianregulationoftranslationfattyacidmetabolicprocessglycogenbiosyntheticprocesshistoneH3deacetylationlactatebiosyntheticprocessnegativeregulationofDNA-templatedtranscriptionterminationnegativeregulationoffatcellproliferationnegativeregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationofcold-inducedthermogenesisregulationofcellcycleregulationofglutamateuptakeinvolvedintransmissionofnerveimpulseregulationofinsulinsecretionregulationofneurogenesisregulationofvasoconstrictionresponsetoischemiawhitefatcelldifferentiation
Serine protease 1
233
Serine protease 1
132
8.3
78
0.15
TRY1TRY1P00760P00760digestionproteolysis
Glial cell line-derived neurotrophic factor
178
Glial cell line-derived neurotrophic factor
149
8.0
60
0.21
GDNFGDNFQ07731Q07731branchinginvolvedinuretericbudmorphogenesiscellpopulationproliferationcellularresponsetodexamethasonestimuluscommissuralneuronaxonguidancedorsalspinalcorddevelopmentembryonicorgandevelopmententericnervoussystemdevelopmentmalegonaddevelopmentmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesismetanephrosdevelopmentmidbraindevelopmentmRNAstabilizationnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofneuronapoptoticprocessnervoussystemdevelopmentneuralcrestcellmigrationneurondifferentiationneuronprojectiondevelopmentorganinductionperipheralnervoussystemdevelopmentperistalsispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesispositiveregulationofmonooxygenaseactivitypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofuretericbudformationpostganglionicparasympatheticfiberdevelopmentpostsynapticmembraneorganizationregulationofdopamineuptakeinvolvedinsynaptictransmissionregulationofgeneexpressionregulationofmorphogenesisofabranchingstructureregulationofsemaphorin-plexinsignalingpathwayregulationofuretericbudformationresponsetowoundingretinadevelopmentincamera-typeeyesympatheticnervoussystemdevelopmenturetericbuddevelopmenturetericbudformation
Vascular endothelial growth factor C
156
Vascular endothelial growth factor C
211
9.9
72
0.14
VEGFCVEGFCP49767P49767animalorganmorphogenesiscellularresponsetoleukemiainhibitoryfactorglialcellproliferationinductionofpositivechemotaxismorphogenesisofembryonicepitheliumnegativeregulationofbloodpressurenegativeregulationofosteoblastdifferentiationpositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellproliferationpositiveregulationofglialcellproliferationpositiveregulationoflymphangiogenesispositiveregulationofmastcellchemotaxispositiveregulationofmesenchymalstemcellproliferationpositiveregulationofneuroblastproliferationpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayresponsetohypoxiaresponsetoxenobioticstimulussignaltransductionsproutingangiogenesissubstrate-dependentcellmigrationvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathway
Serine hydroxymethyltransferase, mitochondrial
91
Serine hydroxymethyltransferase, mitochondrial
68
7.9
85
0.15
GLYMGLYMP34897P34897folicacidmetabolicprocessglycinebiosyntheticprocessfromserineglycinemetabolicprocessL-serinebiosyntheticprocessL-serinecatabolicprocessL-serinemetabolicprocessone-carbonmetabolicprocesspositiveregulationofcellpopulationproliferationproteinhomotetramerizationproteinK63-linkeddeubiquitinationproteintetramerizationpurinenucleobasebiosyntheticprocessregulationofaerobicrespirationregulationofmitochondrialtranslationregulationofoxidativephosphorylationresponsetotypeIinterferontetrahydrofolateinterconversiontetrahydrofolatemetabolicprocess
General transcription factor IIH subunit 3
142
General transcription factor IIH subunit 2
382
10.0
87
0.12
TF2H3TF2H2Q13889Q13888DNArepairnucleotide-excisionrepairphosphorylationofRNApolymeraseIIC-terminaldomaintranscriptionbyRNApolymeraseIIGprotein-coupledreceptorinternalizationpositiveregulationofDNAhelicaseactivityregulationoftranscriptionbyRNApolymeraseIIresponsetoUVtranscriptioninitiationfromRNApolymeraseIIpromoter
Interleukin-17A
146
Interleukin-17F
154
7.9
96
0.13
IL17IL17FQ16552Q96PD4adaptiveimmuneresponseapoptoticprocesscelldeathcell-cellsignalingcellularresponsetointerleukin-1defenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumfibroblastactivationgranulocytemigrationimmuneresponseinflammatoryresponseinnateimmuneresponseinterleukin-17-mediatedsignalingpathwayintestinalepithelialstructuremaintenanceNotchsignalingpathwaypositiveregulationofantimicrobialpeptideproductionpositiveregulationofbicellulartightjunctionassemblypositiveregulationofchemokine(C-X-Cmotif)ligand1productionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-16productionpositiveregulationofinterleukin-23productionpositiveregulationofinterleukin-6productionpositiveregulationofosteoclastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductioncartilagedevelopmentnegativeregulationofangiogenesispositiveregulationofcytokineproductionpositiveregulationoflymphotoxinAproductionregulationofgranulocytemacrophagecolony-stimulatingfactorproductionregulationofinterleukin-2productionregulationofinterleukin-6productionregulationofinterleukin-8productionregulationoftransforminggrowthfactorbetareceptorsignalingpathway
Cryptochrome-2
381
Period circadian protein homolog 2
1210
9.1
76
0.14
CRY2PER2Q9R194O54943circadianregulationofgeneexpressioncircadianrhythmentrainmentofcircadianclockbyphotoperiodglucosehomeostasislipidstoragenegativeregulationofcircadianrhythmnegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofglucocorticoidsecretionnegativeregulationofphosphoproteinphosphataseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedproteinimportintonucleusregulationofcircadianrhythmregulationofsodium-dependentphosphatetransportresponsetoactivityresponsetoinsulinresponsetolightstimuluscircadianregulationoftranslationfattyacidmetabolicprocessgluconeogenesisglycogenbiosyntheticprocesshistoneH3deacetylationlactatebiosyntheticprocessnegativeregulationofDNA-templatedtranscriptionterminationnegativeregulationoffatcellproliferationnegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationofcold-inducedthermogenesisregulationofcellcycleregulationofglutamateuptakeinvolvedintransmissionofnerveimpulseregulationofinsulinsecretionregulationofneurogenesisregulationofvasoconstrictionresponsetoischemiawhitefatcelldifferentiation
Cysteine desulfurase, mitochondrial
381
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
138
6.3
89
0.18
NFS1ISCUQ9Y697Q9H1K12Fe-2Sclusterassemblyironincorporationintometallo-sulfurclusteriron-sulfurclusterassemblyMo-molybdopterincofactorbiosyntheticprocesscellularironionhomeostasisnegativeregulationofironionimportacrossplasmamembranepositiveregulationofaconitatehydrataseactivitypositiveregulationofmitochondrialelectrontransportNADHtoubiquinone
Interleukin-4
151
Interleukin-13 receptor subunit alpha-1
320
8.8
51
0.22
IL4I13R1P05112P78552activationofJanuskinaseactivityBcellcostimulationBcelldifferentiationcholesterolmetabolicprocessdendriticcelldifferentiationextrinsicapoptoticsignalingpathwayinabsenceofligandimmuneresponseinnateimmuneresponseinmucosamacrophageactivationmicroglialcellactivationmyeloiddendriticcelldifferentiationnegativeregulationofacuteinflammatoryresponsenegativeregulationofapoptoticprocessnegativeregulationofcellularresponsetotransforminggrowthfactorbetastimulusnegativeregulationofchronicinflammatoryresponsenegativeregulationofcomplement-dependentcytotoxicitynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofepithelialcellmigrationnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofinflammatoryresponsenegativeregulationofmacrophageactivationnegativeregulationofneuroinflammatoryresponsenegativeregulationofosteoclastdifferentiationnegativeregulationofT-helper17celldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftumornecrosisfactorproductionneuroinflammatoryresponsepositiveregulationofamyloid-betaclearancepositiveregulationofATPbiosyntheticprocesspositiveregulationofBcellproliferationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellularrespirationpositiveregulationofcold-inducedthermogenesispositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofeosinophilchemotaxispositiveregulationofgeneexpressionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-13productionpositiveregulationofisotypeswitchingtoIgEisotypespositiveregulationofisotypeswitchingtoIgGisotypespositiveregulationofmacroautophagypositiveregulationofmastcelldegranulationpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofmononuclearcellmigrationpositiveregulationofmyoblastfusionpositiveregulationofreceptor-mediatedendocytosispositiveregulationofTcelldifferentiationpositiveregulationofTcellproliferationpositiveregulationofT-helper2cellcytokineproductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofimmuneresponseregulationofisotypeswitchingregulationofphosphorylationTcellactivationT-helper2celldifferentiationtype2immuneresponsecellsurfacereceptorsignalingpathwaycytokine-mediatedsignalingpathwayoncostatin-M-mediatedsignalingpathway
Proprotein convertase subtilisin/kexin type 9
378
Low-density lipoprotein receptor
329
8.1
84
0.15
PCSK9LDLRQ8NBP7P01130apoptoticprocesscellularresponsetoinsulinstimuluscellularresponsetostarvationcholesterolhomeostasischolesterolmetabolicprocesskidneydevelopmentlipoproteinmetabolicprocessliverdevelopmentlow-densitylipoproteinparticlereceptorcatabolicprocesslysosomaltransportnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationoflow-densitylipoproteinparticlereceptorbindingnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofreceptorinternalizationnegativeregulationofreceptorrecyclingnegativeregulationofreceptor-mediatedendocytosisinvolvedincholesteroltransportnegativeregulationofsodiumiontransmembranetransporteractivityneurogenesisneurondifferentiationphospholipidmetabolicprocesspositiveregulationoflow-densitylipoproteinparticlereceptorcatabolicprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofreceptorinternalizationproteinautoprocessingregulationofneuronapoptoticprocessregulationofsignalingreceptoractivitytriglyceridemetabolicprocessamyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessarterymorphogenesiscellularresponsetofattyacidcellularresponsetolow-densitylipoproteinparticlestimuluscholesterolimportcholesteroltransportendocytosishigh-densitylipoproteinparticleclearanceintestinalcholesterolabsorptionlipidmetabolicprocesslipoproteincatabolicprocesslong-termmemorylow-densitylipoproteinparticleclearancenegativeregulationofamyloidfibrilformationnegativeregulationofastrocyteactivationnegativeregulationofgeneexpressionnegativeregulationofmicroglialcellactivationnegativeregulationofproteinmetabolicprocessphagocytosisphospholipidtransportplasmalipoproteinparticleclearancepositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationoflysosomalproteincatabolicprocesspositiveregulationoftriglyceridebiosyntheticprocessreceptor-mediatedendocytosisreceptor-mediatedendocytosisinvolvedincholesteroltransportregulationofcholesterolmetabolicprocessregulationofphosphatidylcholinecatabolicprocessregulationofproteinmetabolicprocessresponsetocaloricrestriction
Brain-derived neurotrophic factor
141
Neurotrophin-3
248
8.9
84
0.13
BDNFNTF3P23560P20783axonguidancebrain-derivedneurotrophicfactorreceptorsignalingpathwaycollateralsproutingmemorymodulationofchemicalsynaptictransmissionnegativeregulationofapoptoticsignalingpathwaynegativeregulationofmyotubedifferentiationnegativeregulationofneuronapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwaynervoussystemdevelopmentneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofbrain-derivedneurotrophicfactorreceptorsignalingpathwaypositiveregulationofcollateralsproutingpositiveregulationofneuronprojectiondevelopmentpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofreceptorbindingpositiveregulationofsynapseassemblyregulationofneurondifferentiationregulationofproteinlocalizationtocellsurfacesynapseassemblytransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofGTPaseactivityactivationofproteinkinaseBactivitycell-cellsignalinginductionofpositivechemotaxisnegativeregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofactincytoskeletonreorganizationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofreceptorinternalizationregulationofapoptoticprocesssignaltransduction
F-box only protein 11
853
F-box only protein 11
890
8.8
65
0.17
FBX11FBX11Q86XK2Q86XK2proteinmodificationprocessproteinubiquitinationregulationofapoptoticprocesssensoryperceptionofsoundubiquitin-dependentproteincatabolicprocess
C-C chemokine receptor type 5
20
C-C motif chemokine 5
57
8.9
77
0.15
CCR5CCL5P51681P13501calciumiontransportcalcium-mediatedsignalingcellchemotaxiscellsurfacereceptorsignalingpathwaycell-cellsignalingcellulardefenseresponsecellularresponsetolipopolysaccharidechemotaxisdendriticcellchemotaxisGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseMAPKcascadepositiveregulationofcytosoliccalciumionconcentrationreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolsignalingactivationofphospholipaseDactivitycellularcalciumionhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetoviruschemokine-mediatedsignalingpathwayeosinophilchemotaxisexocytosisleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxismonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofinnateimmuneresponsepositiveregulationofmacrophagechemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftranslationalinitiationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofviralgenomereplicationproteinkinaseBsignalingregulationofchronicinflammatoryresponseregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetotoxicsubstanceresponsetovirus
Hsc70-interacting protein
208
Hsc70-interacting protein
208
3.6
74
0.37
F10A1F10A1P50503P50503chaperonecofactor-dependentproteinrefoldingnegativeregulationofproteinrefoldingresponsetobacterium
Beta-nerve growth factor
231
Beta-nerve growth factor
231
7.9
94
0.13
NGFNGFP01139P01139activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessadultlocomotorybehavioraxonextensioncircadianrhythmextrinsicapoptoticsignalingpathwayinabsenceofligandextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsmemorymodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnegativeregulationoftypeBpancreaticcellapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwayneuronapoptoticprocessneuronprojectiondevelopmentneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofaxonextensionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofcollateralsproutingpositiveregulationofDNAbindingpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofneurondifferentiationpositiveregulationofneuronmaturationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofneurotrophinTRKreceptorsignalingpathwaypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinautophosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinphosphorylationpositiveregulationofproteinubiquitinationpositiveregulationofRasproteinsignaltransductionpositiveregulationofstemcellproliferationproteinphosphorylationregulationofneurondifferentiationregulationofneurotransmittersecretionregulationofreleaseofsequesteredcalciumionintocytosolsensoryperceptionofpaintransmembranereceptorproteintyrosinekinasesignalingpathway
Interleukin-4
151
Cytokine receptor common subunit gamma
231
8.4
56
0.21
IL4IL2RGP05112P31785activationofJanuskinaseactivityBcellcostimulationBcelldifferentiationcholesterolmetabolicprocessdendriticcelldifferentiationextrinsicapoptoticsignalingpathwayinabsenceofligandimmuneresponseinnateimmuneresponseinmucosamacrophageactivationmicroglialcellactivationmyeloiddendriticcelldifferentiationnegativeregulationofacuteinflammatoryresponsenegativeregulationofapoptoticprocessnegativeregulationofcellularresponsetotransforminggrowthfactorbetastimulusnegativeregulationofchronicinflammatoryresponsenegativeregulationofcomplement-dependentcytotoxicitynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofepithelialcellmigrationnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofinflammatoryresponsenegativeregulationofmacrophageactivationnegativeregulationofneuroinflammatoryresponsenegativeregulationofosteoclastdifferentiationnegativeregulationofT-helper17celldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftumornecrosisfactorproductionneuroinflammatoryresponsepositiveregulationofamyloid-betaclearancepositiveregulationofATPbiosyntheticprocesspositiveregulationofBcellproliferationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellularrespirationpositiveregulationofcold-inducedthermogenesispositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofeosinophilchemotaxispositiveregulationofgeneexpressionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-13productionpositiveregulationofisotypeswitchingtoIgEisotypespositiveregulationofisotypeswitchingtoIgGisotypespositiveregulationofmacroautophagypositiveregulationofmastcelldegranulationpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofmononuclearcellmigrationpositiveregulationofmyoblastfusionpositiveregulationofreceptor-mediatedendocytosispositiveregulationofTcelldifferentiationpositiveregulationofTcellproliferationpositiveregulationofT-helper2cellcytokineproductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofimmuneresponseregulationofisotypeswitchingregulationofphosphorylationTcellactivationT-helper2celldifferentiationtype2immuneresponseCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationcytokine-mediatedsignalingpathwaygeneexpressioninterleukin-15-mediatedsignalingpathwayinterleukin-2-mediatedsignalingpathwayinterleukin-4-mediatedsignalingpathwayinterleukin-7-mediatedsignalingpathwaymatureBcelldifferentiationpositiveregulationofBcelldifferentiationpositiveregulationofCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationpositiveregulationofphagocytosispositiveregulationofTcelldifferentiationinthymussignaltransductionTcelldifferentiationinthymus
Tumor necrosis factor receptor superfamily member 9
64
Tumor necrosis factor receptor superfamily member 9
31
8.9
68
0.17
TNR9TNR9P20334P20334apoptoticprocessnegativeregulationofcellpopulationproliferationregulationofcellpopulationproliferationregulationofimmatureTcellproliferationinthymus
E3 ubiquitin-protein ligase parkin
352
E3 ubiquitin-protein ligase parkin
323
9.0
64
0.17
PRKNPRKNQ9JK66Q9JK66adultlocomotorybehavioraggresomeassemblyautophagyofmitochondrionbraindevelopmentcellularresponsetohydrogensulfidecellularresponsetoL-glutamatecellularresponsetoL-glutaminecellularresponsetomanganeseioncellularresponsetotoxicsubstancedopaminemetabolicprocessdopamineuptakeinvolvedinsynaptictransmissionfreeubiquitinchainpolymerizationlearninglocomotorybehaviormitochondrialfissionmitochondrialfragmentationinvolvedinapoptoticprocessmitochondrionlocalizationmitochondrionorganizationmitochondriontolysosometransportmitophagymodulationofchemicalsynaptictransmissionnegativeregulationbyhostofviralgenomereplicationnegativeregulationofactinfilamentbundleassemblynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcelldeathnegativeregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofendoplasmicreticulumstress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofexcitatorypostsynapticpotentialnegativeregulationofexosomalsecretionnegativeregulationofgeneexpressionnegativeregulationofglucokinaseactivitynegativeregulationofinsulinsecretionnegativeregulationofintralumenalvesicleformationnegativeregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatornegativeregulationofJNKcascadenegativeregulationofmitochondrialfissionnegativeregulationofmitochondrialfusionnegativeregulationofneuronapoptoticprocessnegativeregulationofneurondeathnegativeregulationofoxidativestress-inducedneurondeathnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofprimaryamineoxidaseactivitynegativeregulationofproteinphosphorylationnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofspontaneousneurotransmittersecretionnegativeregulationofsynaptictransmissionglutamatergicnegativeregulationoftranscriptionbyRNApolymeraseIIneuroncellularhomeostasisnorepinephrinemetabolicprocessparkin-mediatedstimulationofmitophagyinresponsetomitochondrialdepolarizationpositiveregulationofapoptoticprocesspositiveregulationofATPbiosyntheticprocesspositiveregulationofautophagyofmitochondrionpositiveregulationofdendriteextensionpositiveregulationofDNAbindingpositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofmitochondrialfissionpositiveregulationofmitochondrialfusionpositiveregulationofmitochondrialmembranepotentialpositiveregulationofmitophagypositiveregulationofmitophagyinresponsetomitochondrialdepolarizationpositiveregulationofneurotransmitteruptakepositiveregulationofproteasomalproteincatabolicprocesspositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinbindingpositiveregulationofproteinlinearpolyubiquitinationpositiveregulationofproteinlocalizationtomembranepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayproteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautoubiquitinationproteindestabilizationproteinK11-linkedubiquitinationproteinK48-linkedubiquitinationproteinK6-linkedubiquitinationproteinK63-linkedubiquitinationproteinlocalizationtomitochondrionproteinmetabolicprocessproteinmonoubiquitinationproteinpolyubiquitinationproteinstabilizationproteinubiquitinationregulationofapoptoticprocessregulationofautophagyregulationofcellularresponsetooxidativestressregulationofdopaminemetabolicprocessregulationofgeneexpressionregulationofmitochondrialmembranepotentialregulationofmitochondrionorganizationregulationofneurotransmittersecretionregulationofproteinstabilityregulationofproteinubiquitinationregulationofreactiveoxygenspeciesmetabolicprocessresponsetocorticosteroneresponsetocurcuminresponsetoendoplasmicreticulumstressresponsetomuscleactivityresponsetooxidativestressresponsetounfoldedproteinresponsetoxenobioticstimulusstartleresponsesynaptictransmissiondopaminergicsynaptictransmissionglutamatergicubiquitin-dependentproteincatabolicprocesszincionhomeostasis
Pancreatic trypsin inhibitor
40
Pancreatic trypsin inhibitor
65
8.1
62
0.2
BPT1BPT1P00974P00974negativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Mothers against decapentaplegic homolog 3
394
Mothers against decapentaplegic homolog 3
421
9.5
68
0.16
SMAD3SMAD3P84022P84022activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwayactivinreceptorsignalingpathwayadrenalglanddevelopmentanatomicalstructuremorphogenesisBMPsignalingpathwaycelldifferentiationcell-celljunctionorganizationcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetovirusdevelopmentalgrowthembryoniccranialskeletonmorphogenesisembryonicforegutmorphogenesisembryonicpatternspecificationendodermdevelopmentextrinsicapoptoticsignalingpathwayheartloopingimmuneresponseimmunesystemdevelopmentinuteroembryonicdevelopmentJNKcascadelensfibercelldifferentiationliverdevelopmentmesodermformationnegativeregulationofapoptoticprocessnegativeregulationofcardiacmusclehypertrophyinresponsetostressnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcytosoliccalciumionconcentrationnegativeregulationoffatcelldifferentiationnegativeregulationofinflammatoryresponsenegativeregulationoflungbloodpressurenegativeregulationofosteoblastdifferentiationnegativeregulationofosteoblastproliferationnegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofwoundhealingnodalsignalingpathwayosteoblastdevelopmentparaxialmesodermmorphogenesispericardiumdevelopmentpositiveregulationofalkalinephosphataseactivitypositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofchondrocytedifferentiationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofextracellularmatrixassemblypositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofinterleukin-1betaproductionpositiveregulationofmiRNAtranscriptionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofpositivechemotaxispositiveregulationofproteinimportintonucleuspositiveregulationofstressfiberassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransforminggrowthfactorbeta3productionprimarymiRNAprocessingproteinstabilizationregulationofbindingregulationofepithelialcellproliferationregulationofimmuneresponseregulationofmiRNAtranscriptionregulationofstriatedmuscletissuedevelopmentregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiasignaltransductioninvolvedinregulationofgeneexpressionSMADproteincomplexassemblySMADproteinsignaltransductionsomitogenesisTcellactivationthyroidglanddevelopmenttransdifferentiationtransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentwoundhealing
Protein unc-13 homolog A
5
Regulating synaptic membrane exocytosis protein 2
95
9.8
62
0.16
UN13ARIMS2Q62768Q9JIS1amyloid-betametabolicprocesscelldifferentiationdensecoregranulepriminginnervationlong-termsynapticpotentiationneuromuscularjunctiondevelopmentneuronaldensecorevesicleexocytosisneurotransmittersecretionpositiveregulationofdendriteextensionpositiveregulationofglutamatereceptorsignalingpathwaypositiveregulationofneurotransmittersecretionpositiveregulationofsynapticplasticitypresynapticdensecorevesicleexocytosisregulationofamyloidprecursorproteincatabolicprocessregulationofshort-termneuronalsynapticplasticityregulationofsynapticvesicleprimingsynaptictransmissionglutamatergicsynapticvesicledockingsynapticvesicleexocytosissynapticvesiclematurationsynapticvesicleprimingadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycalciumion-regulatedexocytosisofneurotransmittercalcium-ionregulatedexocytosisexocytosisinsulinsecretionintracellularproteintransportpositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofgeneexpressionpositiveregulationofinhibitorypostsynapticpotentialpositiveregulationofsynaptictransmissionregulationofexocytosisregulationofmembranepotentialregulationofsynapticplasticityspontaneousneurotransmittersecretion
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
414
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
414
7.3
66
0.21
PDE10PDE10Q9Y233Q9Y233cAMPcatabolicprocesscGMPcatabolicprocessnegativeregulationofcGMP-mediatedsignalingsignaltransduction
Seminal ribonuclease
58
Seminal ribonuclease
58
7.3
57
0.24
RNSRNSP00669P00669defenseresponsetoGram-positivebacteriumRNAphosphodiesterbondhydrolysis
cAMP-dependent protein kinase type II-beta regulatory subunit
114
cAMP-dependent protein kinase catalytic subunit alpha
200
4.9
68
0.3
KAP3KAPCAP31324P05132fattyacidmetabolicprocesslearningmodulationofchemicalsynaptictransmissionnegativeregulationofcAMP-dependentproteinkinaseactivityregulationofproteinkinaseactivityresponsetoantipsychoticdrugresponsetoclozapinecellularresponsetocoldcellularresponsetoglucosestimuluscellularresponsetoheatcellularresponsetoparathyroidhormonestimulusmesodermformationmRNAprocessingnegativeregulationofmeioticcellcyclenegativeregulationofsmoothenedsignalingpathwayinvolvedindorsal/ventralneuraltubepatterningneuraltubeclosurepeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofcellpopulationproliferationpositiveregulationofproteinexportfromnucleusproteinautophosphorylationproteinexportfromnucleusproteinkinaseAsignalingproteinlocalizationtolipiddropletproteinphosphorylationregulationofbicellulartightjunctionassemblyregulationofcellcycleregulationofcellularrespirationregulationofosteoblastdifferentiationregulationofproteasomalproteincatabolicprocessregulationofproteinprocessingregulationofsynaptictransmissionglutamatergicspermcapacitationspontaneousexocytosisofneurotransmitter
Mothers against decapentaplegic homolog 3
421
Mothers against decapentaplegic homolog 4
523
8.5
68
0.17
SMAD3SMAD4P84022Q13485activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwayactivinreceptorsignalingpathwayadrenalglanddevelopmentanatomicalstructuremorphogenesisBMPsignalingpathwaycelldifferentiationcell-celljunctionorganizationcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetovirusdevelopmentalgrowthembryoniccranialskeletonmorphogenesisembryonicforegutmorphogenesisembryonicpatternspecificationendodermdevelopmentextrinsicapoptoticsignalingpathwayheartloopingimmuneresponseimmunesystemdevelopmentinuteroembryonicdevelopmentJNKcascadelensfibercelldifferentiationliverdevelopmentmesodermformationnegativeregulationofapoptoticprocessnegativeregulationofcardiacmusclehypertrophyinresponsetostressnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcytosoliccalciumionconcentrationnegativeregulationoffatcelldifferentiationnegativeregulationofinflammatoryresponsenegativeregulationoflungbloodpressurenegativeregulationofosteoblastdifferentiationnegativeregulationofosteoblastproliferationnegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofwoundhealingnodalsignalingpathwayosteoblastdevelopmentparaxialmesodermmorphogenesispericardiumdevelopmentpositiveregulationofalkalinephosphataseactivitypositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofchondrocytedifferentiationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofextracellularmatrixassemblypositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofinterleukin-1betaproductionpositiveregulationofmiRNAtranscriptionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofpositivechemotaxispositiveregulationofproteinimportintonucleuspositiveregulationofstressfiberassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransforminggrowthfactorbeta3productionprimarymiRNAprocessingproteinstabilizationregulationofbindingregulationofepithelialcellproliferationregulationofimmuneresponseregulationofmiRNAtranscriptionregulationofstriatedmuscletissuedevelopmentregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiasignaltransductioninvolvedinregulationofgeneexpressionSMADproteincomplexassemblySMADproteinsignaltransductionsomitogenesisTcellactivationthyroidglanddevelopmenttransdifferentiationtransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentwoundhealingagingatrioventricularcanaldevelopmentatrioventricularvalveformationaxonguidancebrainstemdevelopmentbranchinginvolvedinuretericbudmorphogenesiscardiacconductionsystemdevelopmentcellpopulationproliferationcellularironionhomeostasiscellularresponsetoBMPstimuluscellularresponsetoglucosestimulusembryonicdigitmorphogenesisendocardialcelldifferentiationendothelialcellactivationepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationERK1andERK2cascadefemalegonadmorphogenesisformationofanatomicalboundarygastrulationwithmouthformingsecondinterleukin-6-mediatedsignalingpathwayintracellularsignaltransductionleftventricularcardiacmuscletissuemorphogenesismesendodermdevelopmentmetanephricmesenchymemorphogenesisnegativeregulationofcardiacmusclehypertrophynegativeregulationofcardiacmyofibrilassemblynegativeregulationofcelldeathnegativeregulationofERK1andERK2cascadenegativeregulationoftranscriptionDNA-templatednephrogenicmesenchymemorphogenesisneuralcrestcelldifferentiationneuronfatecommitmentosteoblastdifferentiationoutflowtractseptummorphogenesisovarianfollicledevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcellproliferationinvolvedinheartvalvemorphogenesispositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofhistoneH3-K4methylationpositiveregulationofhistoneH3-K9acetylationpositiveregulationofluteinizinghormonesecretionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimuluspositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationofhairfollicledevelopmentresponsetotransforminggrowthfactorbetasebaceousglanddevelopmentsecondarypalatedevelopmentseminiferoustubuledevelopmentsinglefertilizationsomiterostral/caudalaxisspecificationspermatogenesistranscriptionbyRNApolymeraseIItranscriptionDNA-templateduterusdevelopmentventricularseptummorphogenesis
Fibrinogen gamma-B chain
32
Fibrinogen gamma-B chain
32
5.9
50
0.34
FIBGFIBGP12799P12799bloodcoagulationfibrinclotformationcell-matrixadhesionplateletaggregationproteinpolymerization
PRSS3 protein
68
Pancreatic trypsin inhibitor
49
8.6
93
0.12
Q8N2U3BPT1Q8N2U3P00974proteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Thymidylate synthase
43
Thymidylate synthase
43
9.7
52
0.2
TYSYTYSYP04818P04818agingcartilagedevelopmentcircadianrhythmdevelopmentalgrowthDNAbiosyntheticprocessdTMPbiosyntheticprocessdTTPbiosyntheticprocessintestinalepithelialcellmaturationliverregenerationmethylationnegativeregulationoftranslationresponsetocytokineresponsetoethanolresponsetofolicacidresponsetoglucocorticoidresponsetoorganophosphorusresponsetoprogesteroneresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulustetrahydrofolateinterconversionuracilmetabolicprocess
PRSS3 protein
68
Amyloid-beta A4 protein
222
8.5
95
0.12
Q8N2U3H7C0V9Q8N2U3H7C0V9proteolysisnervoussystemdevelopment
Glycoprotein hormones alpha chain
111
Follitropin subunit beta
105
8.9
74
0.15
GLHAFSHBP01215P01225follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationfemalegametegenerationfemalepregnancypositiveregulationofboneresorptionpositiveregulationofgeneexpressionprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationSertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Prostaglandin-H2 D-isomerase
89
Prostaglandin-H2 D-isomerase
186
8.5
68
0.17
PTGDSPTGDSP41222P41222cyclooxygenasepathwaygeneexpressionmastcelldegranulationnegativeregulationofmalegermcellproliferationprostaglandinbiosyntheticprocessregulationofcircadiansleep/wakecyclesleepresponsetoglucocorticoid
Seminal ribonuclease
57
Seminal ribonuclease
57
7.1
69
0.2
RNSRNSP00669P00669defenseresponsetoGram-positivebacteriumRNAphosphodiesterbondhydrolysis
Serine/threonine-protein kinase VRK1
220
Serine/threonine-protein kinase VRK1
220
3.9
82
0.31
VRK1VRK1Q99986Q99986celldivisioncellularresponsetoDNAdamagestimulusGolgidisassemblyhistonephosphorylationmitoticnuclearmembranedisassemblypeptidyl-serinephosphorylationpositiveregulationofproteinlocalizationtochromatinproteinautophosphorylationproteinphosphorylationsignaltransduction
Platelet factor 4
27
Platelet factor 4
27
8.9
75
0.15
PLF4PLF4P02777P02777adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaycytokine-mediatedsignalingpathwayinflammatoryresponseleukocytechemotaxisnegativeregulationofangiogenesisnegativeregulationofmegakaryocytedifferentiationneutrophilchemotaxisplateletactivationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellpopulationproliferation
PRKCA-binding protein
46
PRKCA-binding protein
46
8.2
76
0.16
PICK1PICK1Q9NRD5Q9NRD5cellularresponsetodecreasedoxygenlevelscellularresponsetoglucosestarvationdendriticspinemaintenancedendriticspineorganizationDNAmethylationinvolvedinembryodevelopmentDNAmethylationinvolvedingametegenerationglialcelldevelopmentintracellularproteintransportlong-termsynapticdepressionmonoaminetransportnegativeregulationofArp2/3complex-mediatedactinnucleationneuronalionchannelclusteringpositiveregulationofreceptorinternalizationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteinphosphorylationreceptorclusteringregulationofArp2/3complex-mediatedactinnucleationregulationofinsulinsecretionretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulum
Nuclear transport factor 2
80
Nuclear transport factor 2
80
7.3
67
0.21
NTF2NTF2P61972P61972mRNAtransportnegativeregulationofvascularendothelialgrowthfactorproductionnucleocytoplasmictransportpositiveregulationofproteinimportintonucleusproteinexportfromnucleusproteinimportintonucleusproteinlocalizationtonuclearpore
Peptidyl-prolyl cis-trans isomerase FKBP5
183
Peptidyl-prolyl cis-trans isomerase FKBP5
183
5.1
66
0.3
FKBP5FKBP5Q13451Q13451chaperone-mediatedproteinfoldingproteinfoldingproteinpeptidyl-prolylisomerizationresponsetobacterium
ATP-citrate synthase
293
ATP-citrate synthase
748
5.1
68
0.29
ACLYACLYP53396P53396acetyl-CoAbiosyntheticprocesscholesterolbiosyntheticprocesscitratemetabolicprocesscoenzymeAmetabolicprocessfattyacidbiosyntheticprocesslipidbiosyntheticprocessoxaloacetatemetabolicprocess
Cytosolic iron-sulfur assembly component 2A
90
Cytosolic iron-sulfur assembly component 2A
90
3.9
74
0.35
CIA2ACIA2AQ9H5X1Q9H5X1chromosomesegregationiron-sulfurclusterassemblyproteinmaturationby4Fe-4Sclustertransferproteinmaturationbyiron-sulfurclustertransfer
NADPH oxidase activator 1
451
NADPH oxidase activator 1
451
5.0
56
0.36
NOXA1NOXA1Q86UR1Q86UR1regulationofhydrogenperoxidemetabolicprocessregulationofrespiratoryburstsuperoxideaniongenerationsuperoxidemetabolicprocess
Estrogen receptor
530
Estrogen receptor
417
5.0
48
0.42
ESR1ESR1P03372P03372androgenmetabolicprocessantralovarianfolliclegrowthcellularresponsetoestradiolstimuluscellularresponsetoestrogenstimuluschromatinremodelingepithelialcelldevelopmentepithelialcellproliferationinvolvedinmammaryglandductelongationfibroblastproliferationintracellularestrogenreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaymalegonaddevelopmentmammaryglandalveolusdevelopmentmammaryglandbranchinginvolvedinpregnancynegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofgeneexpressionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofmiRNAmaturationnegativeregulationoftranscriptionbyRNApolymeraseIIphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoffibroblastproliferationpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofphospholipaseCactivitypositiveregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprostateepithelialcordarborizationinvolvedinprostateglandularacinusmorphogenesisprostateepithelialcordelongationproteinlocalizationtochromatinregulationofbranchinginvolvedinprostateglandmorphogenesisregulationofepithelialcellapoptoticprocessregulationofinflammatoryresponseregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetoestradiolresponsetoestrogensignaltransductionstemcelldifferentiationtranscriptionbyRNApolymeraseIIuterusdevelopmentvaginadevelopment
Bcl-2-related protein A1
55
Phorbol-12-myristate-13-acetate-induced protein 1
25
3.9
60
0.43
B2LA1APRQ16548Q13794extrinsicapoptoticsignalingpathwayinabsenceofligandintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocesscellularresponsetoDNAdamagestimuluscellularresponsetoglucosestarvationcellularresponsetohypoxiadefenseresponsetovirusintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwaybyp53classmediatornegativeregulationofmitochondrialmembranepotentialpositiveregulationofapoptoticprocesspositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofDNAdamageresponsesignaltransductionbyp53classmediatorpositiveregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwaypositiveregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorspositiveregulationofglucosemetabolicprocesspositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofreleaseofcytochromecfrommitochondriaproteasomalproteincatabolicprocessreactiveoxygenspeciesmetabolicprocessregulationofmitochondrialmembranepermeabilityreleaseofcytochromecfrommitochondriaresponsetodsRNATcellhomeostasis
Alanine--glyoxylate aminotransferase
84
Alanine--glyoxylate aminotransferase
84
6.0
89
0.19
AGT1AGT1P21549P21549glycinebiosyntheticprocessbytransaminationofglyoxylateglyoxylatecatabolicprocessglyoxylatemetabolicprocessL-alaninecatabolicprocessL-cysteinecatabolicprocessL-serinemetabolicprocessNotchsignalingpathwayoxalicacidsecretion
Frizzled-8
107
Frizzled-8
148
9.7
75
0.14
FZD8FZD8Q61091Q61091angiogenesiscanonicalWntsignalingpathwaypositiveregulationofJUNkinaseactivitypositiveregulationofproteinphosphorylationTcelldifferentiationinthymusWntsignalingpathway
PRSS3 protein
68
Amyloid-beta precursor protein
324
9.7
86
0.12
Q8N2U3A4Q8N2U3P05067proteolysisadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Insulin-like growth factor I
54
Insulin-like growth factor-binding protein 1
206
5.2
87
0.22
IGF1IBP1P05019P08833activationofproteinkinaseBactivitybonemineralizationinvolvedinbonematurationcellactivationcellpopulationproliferationcellularresponsetoamyloid-betaERK1andERK2cascadeglycolatemetabolicprocessinsulin-likegrowthfactorreceptorsignalingpathwaymusclehypertrophymuscleorgandevelopmentmyoblastdifferentiationmyoblastproliferationmyotubecelldevelopmentnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofinterleukin-1betaproductionnegativeregulationofneuroinflammatoryresponsenegativeregulationofoocytedevelopmentnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftumornecrosisfactorproductionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcardiacmusclehypertrophypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRasproteinsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftrophectodermalcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseBsignalingproteinstabilizationproteoglycanbiosyntheticprocessRasproteinsignaltransductionregulationofgeneexpressionregulationofmulticellularorganismgrowthregulationofproteinphosphorylationresponsetoheatsignaltransductionskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationskeletalsystemdevelopmentwoundhealingaginginsulinreceptorsignalingpathwaynegativeregulationofcanonicalWntsignalingpathwaypositiveregulationofcellgrowthregulationofinsulin-likegrowthfactorreceptorsignalingpathwaytissueregeneration
F-box only protein 11
890
F-box only protein 11
865
7.0
64
0.22
FBX11FBX11Q86XK2Q86XK2proteinmodificationprocessproteinubiquitinationregulationofapoptoticprocesssensoryperceptionofsoundubiquitin-dependentproteincatabolicprocess
Interleukin-6 receptor subunit alpha
121
Interleukin-6 receptor subunit alpha
165
9.7
62
0.17
IL6RAIL6RAP08887P08887acute-phaseresponseciliaryneurotrophicfactor-mediatedsignalingpathwaycytokine-mediatedsignalingpathwaydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumendocrinepancreasdevelopmentextrinsicapoptoticsignalingpathwayhepaticimmuneresponseinterleukin-6-mediatedsignalingpathwaymonocytechemotaxisnegativeregulationofcollagenbiosyntheticprocessnegativeregulationofinterleukin-8productionneutrophilmediatedimmunitypositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcellpopulationproliferationpositiveregulationofchemokineproductionpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofinterleukin-6productionpositiveregulationofleukocytechemotaxispositiveregulationofMAPKcascadepositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofplateletaggregationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinresponsetocytokineT-helper17celllineagecommitmentvascularendothelialgrowthfactorproduction
C-C motif chemokine 8
34
C-C motif chemokine 8
34
6.0
75
0.22
CCL8CCL8P80075P80075antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecalciumiontransportcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiseosinophilchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisnegativeregulationbyhostofviralgenomereplicationnegativeregulationofleukocyteproliferationneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofleukocytemigrationresponsetovirussignaltransduction
Insulin-like growth factor-binding protein 4
204
Insulin-like growth factor I
96
6.0
79
0.21
IBP4IGF1P22692P05019inflammatoryresponseMAPKcascadenegativeregulationofcanonicalWntsignalingpathwaypositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascaderegulationofcellgrowthregulationofglucosemetabolicprocessregulationofinsulin-likegrowthfactorreceptorsignalingpathwaysignaltransductiontypeBpancreaticcellproliferationactivationofproteinkinaseBactivitybonemineralizationinvolvedinbonematurationcellactivationcellpopulationproliferationcellularresponsetoamyloid-betaERK1andERK2cascadeglycolatemetabolicprocessinsulin-likegrowthfactorreceptorsignalingpathwaymusclehypertrophymuscleorgandevelopmentmyoblastdifferentiationmyoblastproliferationmyotubecelldevelopmentnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofinterleukin-1betaproductionnegativeregulationofneuroinflammatoryresponsenegativeregulationofoocytedevelopmentnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftumornecrosisfactorproductionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcardiacmusclehypertrophypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRasproteinsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftrophectodermalcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseBsignalingproteinstabilizationproteoglycanbiosyntheticprocessRasproteinsignaltransductionregulationofgeneexpressionregulationofmulticellularorganismgrowthregulationofproteinphosphorylationresponsetoheatskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationskeletalsystemdevelopmentwoundhealing
Neurogenic locus notch homolog protein 3
1484
Neurogenic locus notch homolog protein 3
1484
6.0
58
0.29
NOTC3NOTC3Q9UM47Q9UM47arterymorphogenesisaxonguidanceforebraindevelopmentglomerularcapillaryformationnegativeregulationofneurondifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIneuroblastdifferentiationneuronfatecommitmentNotchsignalingpathwaypositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseII
Complement C5
1101
Complement C5
1101
5.1
85
0.23
CO5CO5P01031P01031cellsurfacereceptorsignalingpathwaychemotaxiscomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisGprotein-coupledreceptorsignalingpathwayinuteroembryonicdevelopmentinflammatoryresponsenegativeregulationofmacrophagechemotaxispositiveregulationofangiogenesispositiveregulationofchemokineproductionpositiveregulationofimmuneresponsepositiveregulationofvascularendothelialgrowthfactorproduction
E3 ubiquitin-protein ligase CBL-C
189
E3 ubiquitin-protein ligase CBL-C
202
3.9
73
0.35
CBLCCBLCQ9ULV8Q9ULV8cellsurfacereceptorsignalingpathwaynegativeregulationofepidermalgrowthfactorreceptorsignalingpathwaynegativeregulationofepidermalgrowthfactor-activatedreceptoractivitynegativeregulationofMAPkinaseactivityproteinubiquitinationsignaltransductionubiquitin-dependentproteincatabolicprocess
Tumor necrosis factor receptor superfamily member 9
77
Tumor necrosis factor receptor superfamily member 9
31
9.4
80
0.13
TNR9TNR9P20334P20334apoptoticprocessnegativeregulationofcellpopulationproliferationregulationofcellpopulationproliferationregulationofimmatureTcellproliferationinthymus
Cryptochrome-2
432
Period circadian protein homolog 2
1210
4.7
74
0.29
CRY2PER2Q9R194O54943circadianregulationofgeneexpressioncircadianrhythmentrainmentofcircadianclockbyphotoperiodglucosehomeostasislipidstoragenegativeregulationofcircadianrhythmnegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofglucocorticoidsecretionnegativeregulationofphosphoproteinphosphataseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedproteinimportintonucleusregulationofcircadianrhythmregulationofsodium-dependentphosphatetransportresponsetoactivityresponsetoinsulinresponsetolightstimuluscircadianregulationoftranslationfattyacidmetabolicprocessgluconeogenesisglycogenbiosyntheticprocesshistoneH3deacetylationlactatebiosyntheticprocessnegativeregulationofDNA-templatedtranscriptionterminationnegativeregulationoffatcellproliferationnegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationofcold-inducedthermogenesisregulationofcellcycleregulationofglutamateuptakeinvolvedintransmissionofnerveimpulseregulationofinsulinsecretionregulationofneurogenesisregulationofvasoconstrictionresponsetoischemiawhitefatcelldifferentiation
Thioredoxin
73
Thioredoxin
35
9.6
76
0.14
THIOTHIOP10599P10599activationofproteinkinaseBactivitycellredoxhomeostasisnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiation
Protein cereblon
326
Protein cereblon
397
9.7
79
0.13
CRBNCRBNQ8C7D2Q8C7D2locomotoryexplorationbehaviornegativeregulationofiontransmembranetransportnegativeregulationoflargeconductancecalcium-activatedpotassiumchannelactivitynegativeregulationofprotein-containingcomplexassemblypositiveregulationofprotein-containingcomplexassemblyproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitination
Small nuclear ribonucleoprotein Sm D2
63
Small nuclear ribonucleoprotein F
66
6.8
79
0.19
SMD2RUXFP62316P623067-methylguanosinecaphypermethylationmRNAsplicingviaspliceosomeRNAsplicingspliceosomalcomplexassemblyspliceosomalsnRNPassemblyU2-typeprespliceosomeassembly
Insulin-like growth factor-binding protein 4
204
Insulin-like growth factor I
54
4.6
87
0.25
IBP4IGF1P22692P05019inflammatoryresponseMAPKcascadenegativeregulationofcanonicalWntsignalingpathwaypositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascaderegulationofcellgrowthregulationofglucosemetabolicprocessregulationofinsulin-likegrowthfactorreceptorsignalingpathwaysignaltransductiontypeBpancreaticcellproliferationactivationofproteinkinaseBactivitybonemineralizationinvolvedinbonematurationcellactivationcellpopulationproliferationcellularresponsetoamyloid-betaERK1andERK2cascadeglycolatemetabolicprocessinsulin-likegrowthfactorreceptorsignalingpathwaymusclehypertrophymuscleorgandevelopmentmyoblastdifferentiationmyoblastproliferationmyotubecelldevelopmentnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofinterleukin-1betaproductionnegativeregulationofneuroinflammatoryresponsenegativeregulationofoocytedevelopmentnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftumornecrosisfactorproductionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcardiacmusclehypertrophypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRasproteinsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftrophectodermalcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseBsignalingproteinstabilizationproteoglycanbiosyntheticprocessRasproteinsignaltransductionregulationofgeneexpressionregulationofmulticellularorganismgrowthregulationofproteinphosphorylationresponsetoheatskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationskeletalsystemdevelopmentwoundhealing
Protein cereblon
326
Protein cereblon
329
9.4
78
0.14
CRBNCRBNQ8C7D2Q8C7D2locomotoryexplorationbehaviornegativeregulationofiontransmembranetransportnegativeregulationoflargeconductancecalcium-activatedpotassiumchannelactivitynegativeregulationofprotein-containingcomplexassemblypositiveregulationofprotein-containingcomplexassemblyproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitination
Complement C5
711
Complement C5
699
9.3
68
0.16
CO5CO5P01031P01031cellsurfacereceptorsignalingpathwaychemotaxiscomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisGprotein-coupledreceptorsignalingpathwayinuteroembryonicdevelopmentinflammatoryresponsenegativeregulationofmacrophagechemotaxispositiveregulationofangiogenesispositiveregulationofchemokineproductionpositiveregulationofimmuneresponsepositiveregulationofvascularendothelialgrowthfactorproduction
Artemin
187
Artemin
218
9.6
66
0.16
ARTNARTNQ5T4W7Q5T4W7axonguidanceinductionofpositivechemotaxislymphocytemigrationintolymphoidorgansneuroblastproliferationperipheralnervoussystemdevelopment"Peyerspatchmorphogenesis"signaltransduction
Proprotein convertase subtilisin/kexin type 9
378
Low-density lipoprotein receptor
340
9.8
74
0.14
PCSK9LDLRQ8NBP7P01130apoptoticprocesscellularresponsetoinsulinstimuluscellularresponsetostarvationcholesterolhomeostasischolesterolmetabolicprocesskidneydevelopmentlipoproteinmetabolicprocessliverdevelopmentlow-densitylipoproteinparticlereceptorcatabolicprocesslysosomaltransportnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationoflow-densitylipoproteinparticlereceptorbindingnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofreceptorinternalizationnegativeregulationofreceptorrecyclingnegativeregulationofreceptor-mediatedendocytosisinvolvedincholesteroltransportnegativeregulationofsodiumiontransmembranetransporteractivityneurogenesisneurondifferentiationphospholipidmetabolicprocesspositiveregulationoflow-densitylipoproteinparticlereceptorcatabolicprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofreceptorinternalizationproteinautoprocessingregulationofneuronapoptoticprocessregulationofsignalingreceptoractivitytriglyceridemetabolicprocessamyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessarterymorphogenesiscellularresponsetofattyacidcellularresponsetolow-densitylipoproteinparticlestimuluscholesterolimportcholesteroltransportendocytosishigh-densitylipoproteinparticleclearanceintestinalcholesterolabsorptionlipidmetabolicprocesslipoproteincatabolicprocesslong-termmemorylow-densitylipoproteinparticleclearancenegativeregulationofamyloidfibrilformationnegativeregulationofastrocyteactivationnegativeregulationofgeneexpressionnegativeregulationofmicroglialcellactivationnegativeregulationofproteinmetabolicprocessphagocytosisphospholipidtransportplasmalipoproteinparticleclearancepositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationoflysosomalproteincatabolicprocesspositiveregulationoftriglyceridebiosyntheticprocessreceptor-mediatedendocytosisreceptor-mediatedendocytosisinvolvedincholesteroltransportregulationofcholesterolmetabolicprocessregulationofphosphatidylcholinecatabolicprocessregulationofproteinmetabolicprocessresponsetocaloricrestriction
cAMP-dependent protein kinase catalytic subunit alpha
200
cAMP-dependent protein kinase type II-beta regulatory subunit
114
4.9
71
0.29
KAPCAKAP3P05132P12369cellularresponsetocoldcellularresponsetoglucosestimuluscellularresponsetoheatcellularresponsetoparathyroidhormonestimulusmesodermformationmodulationofchemicalsynaptictransmissionmRNAprocessingnegativeregulationofmeioticcellcyclenegativeregulationofsmoothenedsignalingpathwayinvolvedindorsal/ventralneuraltubepatterningneuraltubeclosurepeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofcellpopulationproliferationpositiveregulationofproteinexportfromnucleusproteinautophosphorylationproteinexportfromnucleusproteinkinaseAsignalingproteinlocalizationtolipiddropletproteinphosphorylationregulationofbicellulartightjunctionassemblyregulationofcellcycleregulationofcellularrespirationregulationofosteoblastdifferentiationregulationofproteasomalproteincatabolicprocessregulationofproteinprocessingregulationofsynaptictransmissionglutamatergicspermcapacitationspontaneousexocytosisofneurotransmitterfattyacidmetabolicprocesslearningnegativeregulationofcAMP-dependentproteinkinaseactivityregulationofproteinkinaseactivityresponsetoantipsychoticdrugresponsetoclozapine
Cryptochrome-2
430
Period circadian protein homolog 2
1210
6.3
78
0.2
CRY2PER2Q9R194O54943circadianregulationofgeneexpressioncircadianrhythmentrainmentofcircadianclockbyphotoperiodglucosehomeostasislipidstoragenegativeregulationofcircadianrhythmnegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofglucocorticoidsecretionnegativeregulationofphosphoproteinphosphataseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedproteinimportintonucleusregulationofcircadianrhythmregulationofsodium-dependentphosphatetransportresponsetoactivityresponsetoinsulinresponsetolightstimuluscircadianregulationoftranslationfattyacidmetabolicprocessgluconeogenesisglycogenbiosyntheticprocesshistoneH3deacetylationlactatebiosyntheticprocessnegativeregulationofDNA-templatedtranscriptionterminationnegativeregulationoffatcellproliferationnegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationofcold-inducedthermogenesisregulationofcellcycleregulationofglutamateuptakeinvolvedintransmissionofnerveimpulseregulationofinsulinsecretionregulationofneurogenesisregulationofvasoconstrictionresponsetoischemiawhitefatcelldifferentiation
Cyclin-dependent kinase 4
78
Cyclin-dependent kinase inhibitor 1
41
6.0
75
0.22
CDK4CDN1AP11802P38936adiposetissuedevelopmentcelldivisioncellularresponsetoinsulinstimuluscellularresponsetointerleukin-4cellularresponsetoionomycincellularresponsetolipopolysaccharidecellularresponsetophorbol13-acetate12-myristateG1/StransitionofmitoticcellcyclepositiveregulationofcellpopulationproliferationpositiveregulationoffibroblastproliferationpositiveregulationofG2/MtransitionofmitoticcellcycleproteinphosphorylationregulationofcellcycleregulationofgeneexpressionregulationofinsulinreceptorsignalingpathwayregulationoflipidbiosyntheticprocessregulationoflipidcatabolicprocessregulationofmulticellularorganismgrowthregulationoftranscriptioninitiationfromRNApolymeraseIIpromoterregulationoftypeBpancreaticcellproliferationresponsetoxenobioticstimulussignaltransductioncellularresponsetoaminoacidstarvationcellularresponsetoDNAdamagestimuluscellularresponsetoextracellularstimuluscellularresponsetogammaradiationcellularresponsetoionizingradiationcellularresponsetoUV-BcellularsenescenceDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestDNAdamageresponsesignaltransductionbyp53classmediatorresultingintranscriptionofp21classmediatorheartdevelopmentintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatormitoticG2DNAdamagecheckpointsignalingnegativeregulationofcardiacmuscletissueregenerationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcyclin-dependentproteinkinaseactivitynegativeregulationofcyclin-dependentproteinserine/threoninekinaseactivitynegativeregulationofDNAbiosyntheticprocessnegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofgeneexpressionnegativeregulationofphosphorylationnegativeregulationofproteinbindingnegativeregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofBcellproliferationpositiveregulationofprogrammedcelldeathpositiveregulationofproteinkinaseactivitypositiveregulationofreactiveoxygenspeciesmetabolicprocessproteinimportintonucleusRasproteinsignaltransductionregulationofcellcycleG1/Sphasetransitionregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofG1/StransitionofmitoticcellcycleregulationofG2/Mtransitionofmitoticcellcyclereplicativesenescencestress-inducedprematuresenescencetissueregenerationwoundhealing
Brain-derived neurotrophic factor
239
Neurotrophin-3
152
8.8
79
0.14
BDNFNTF3P23560P20783axonguidancebrain-derivedneurotrophicfactorreceptorsignalingpathwaycollateralsproutingmemorymodulationofchemicalsynaptictransmissionnegativeregulationofapoptoticsignalingpathwaynegativeregulationofmyotubedifferentiationnegativeregulationofneuronapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwaynervoussystemdevelopmentneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofbrain-derivedneurotrophicfactorreceptorsignalingpathwaypositiveregulationofcollateralsproutingpositiveregulationofneuronprojectiondevelopmentpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofreceptorbindingpositiveregulationofsynapseassemblyregulationofneurondifferentiationregulationofproteinlocalizationtocellsurfacesynapseassemblytransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofGTPaseactivityactivationofproteinkinaseBactivitycell-cellsignalinginductionofpositivechemotaxisnegativeregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofactincytoskeletonreorganizationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofreceptorinternalizationregulationofapoptoticprocesssignaltransduction
Bone morphogenetic protein 3
370
Bone morphogenetic protein 3
436
8.7
79
0.15
BMP3BMP3P12645P12645cartilagedevelopmentcell-cellsignalingosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationskeletalsystemdevelopmentSMADproteinsignaltransduction
Thioredoxin reductase 1, cytoplasmic
497
Thioredoxin reductase 1, cytoplasmic
59
9.5
70
0.15
TRXR1TRXR1O89049O89049benzene-containingcompoundmetabolicprocesscellpopulationproliferationcellredoxhomeostasiscellularresponsetocopperioncellularresponsetohyperoxiagastrulationhalogenmetabolicprocesshydrogenperoxidecatabolicprocessmesodermformationNADPHoxidationplacentadevelopmentpositiveregulationofcelldeathresponsetoaxoninjuryresponsetohyperoxiaresponsetooxidativestressresponsetoseleniumionresponsetoxenobioticstimulusselenocysteinemetabolicprocess
Eukaryotic translation initiation factor 3 subunit J
207
Eukaryotic translation initiation factor 3 subunit J
188
9.3
68
0.16
EIF3JEIF3JO75822O75822formationofcytoplasmictranslationinitiationcomplextranslationalinitiation
Interleukin-17F
154
Interleukin-17F
154
7.6
96
0.14
IL17FIL17FQ96PD4Q96PD4adaptiveimmuneresponsecartilagedevelopmentdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminflammatoryresponseinnateimmuneresponseinterleukin-17-mediatedsignalingpathwaynegativeregulationofangiogenesispositiveregulationofantimicrobialpeptideproductionpositiveregulationofchemokine(C-X-Cmotif)ligand1productionpositiveregulationofcytokineproductionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofinterleukin-6productionpositiveregulationoflymphotoxinAproductionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofgranulocytemacrophagecolony-stimulatingfactorproductionregulationofinterleukin-2productionregulationofinterleukin-6productionregulationofinterleukin-8productionregulationoftransforminggrowthfactorbetareceptorsignalingpathway
WD repeat-containing protein 48
200
Ubiquitin carboxyl-terminal hydrolase 12
48
6.7
68
0.22
WDR48UBP12Q8TAF3O75317cellularresponsetoDNAdamagestimulusdouble-strandbreakrepairviahomologousrecombinationembryonicorgandevelopmenthomeostasisofnumberofcellsmulticellularorganismgrowthpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofepithelialcellproliferationproteindeubiquitinationregulationofproteinmonoubiquitinationseminiferoustubuledevelopmentsinglefertilizationskeletalsystemmorphogenesisskindevelopmentspermatogenesisubiquitin-dependentproteincatabolicprocess
Hepcidin
81
Neutrophil gelatinase-associated lipocalin
195
7.4
75
0.18
HEPCNGALP81172P80188acute-phaseresponseagingantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularironionhomeostasiscellularresponsetobileacidcellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactorcellularresponsetoX-raydefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumestablishmentoflocalizationincellimmuneresponseironiontransmembranetransportkillingofcellsofanotherorganismliverregenerationmacrophageactivationmulticellularorganismalironionhomeostasismyeloidcellhomeostasisnegativeregulationofboneresorptionnegativeregulationofinflammatoryresponsenegativeregulationofintestinalabsorptionnegativeregulationofiontransmembranetransporteractivitynegativeregulationofironexportacrossplasmamembranenegativeregulationofironiontransmembranetransportnegativeregulationofironiontransmembranetransporteractivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofmacrophageactivationpositiveregulationofproteincatabolicprocesspositiveregulationofproteinpolyubiquitinationpositiveregulationofreceptorcatabolicprocesspositiveregulationofreceptorinternalizationpositiveregulationoftranscriptionbyRNApolymeraseIIproteincatabolicprocessreceptorsignalingpathwayviaJAK-STATresponsetoerythropoietinresponsetoethanolresponsetoironionresponsetoironionstarvationresponsetovitaminAresponsetozinciontranscriptionbyRNApolymeraseIIapoptoticprocessinnateimmuneresponsepositiveregulationofcold-inducedthermogenesissequesteringofironionsiderophoretransport
Defensin alpha 5
92
Defensin alpha 5
82
9.8
nan
nan
DEF5DEF5Q01523Q01523antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismpositiveregulationofinterleukin-8productionpositiveregulationofmembranepermeabilityproteinhomotetramerization
Killer cell lectin-like receptor 3
149
Killer cell lectin-like receptor 3
149
4.6
68
0.32
KLRA3KLRA3Q64329Q64329celladhesion
Neutrophil defensin 1
83
Neutrophil defensin 1
73
9.7
72
0.14
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismmodificationbyhostofsymbiontmembraneTcellchemotaxis
Complement C5
731
Complement C5
699
9.4
79
0.13
CO5CO5P01031P01031cellsurfacereceptorsignalingpathwaychemotaxiscomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisGprotein-coupledreceptorsignalingpathwayinuteroembryonicdevelopmentinflammatoryresponsenegativeregulationofmacrophagechemotaxispositiveregulationofangiogenesispositiveregulationofchemokineproductionpositiveregulationofimmuneresponsepositiveregulationofvascularendothelialgrowthfactorproduction
Pancreatic trypsin inhibitor
40
Pancreatic trypsin inhibitor
86
7.4
60
0.23
BPT1BPT1P00974P00974negativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
cAMP-dependent protein kinase catalytic subunit alpha
200
cAMP-dependent protein kinase type II-alpha regulatory subunit
98
5.1
67
0.29
KAPCAKAP2P05132P12367cellularresponsetocoldcellularresponsetoglucosestimuluscellularresponsetoheatcellularresponsetoparathyroidhormonestimulusmesodermformationmodulationofchemicalsynaptictransmissionmRNAprocessingnegativeregulationofmeioticcellcyclenegativeregulationofsmoothenedsignalingpathwayinvolvedindorsal/ventralneuraltubepatterningneuraltubeclosurepeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofcellpopulationproliferationpositiveregulationofproteinexportfromnucleusproteinautophosphorylationproteinexportfromnucleusproteinkinaseAsignalingproteinlocalizationtolipiddropletproteinphosphorylationregulationofbicellulartightjunctionassemblyregulationofcellcycleregulationofcellularrespirationregulationofosteoblastdifferentiationregulationofproteasomalproteincatabolicprocessregulationofproteinprocessingregulationofsynaptictransmissionglutamatergicspermcapacitationspontaneousexocytosisofneurotransmitternegativeregulationofcAMP-dependentproteinkinaseactivityregulationofproteinkinaseactivity
If kappa light chain
219
Igh protein
149
5.7
nan
nan
A2NHM3Q6PIP8A2NHM3Q6PIP8
Proprotein convertase subtilisin/kexin type 9
378
Low-density lipoprotein receptor
338
9.5
78
0.14
PCSK9LDLRQ8NBP7P01130apoptoticprocesscellularresponsetoinsulinstimuluscellularresponsetostarvationcholesterolhomeostasischolesterolmetabolicprocesskidneydevelopmentlipoproteinmetabolicprocessliverdevelopmentlow-densitylipoproteinparticlereceptorcatabolicprocesslysosomaltransportnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationoflow-densitylipoproteinparticlereceptorbindingnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofreceptorinternalizationnegativeregulationofreceptorrecyclingnegativeregulationofreceptor-mediatedendocytosisinvolvedincholesteroltransportnegativeregulationofsodiumiontransmembranetransporteractivityneurogenesisneurondifferentiationphospholipidmetabolicprocesspositiveregulationoflow-densitylipoproteinparticlereceptorcatabolicprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofreceptorinternalizationproteinautoprocessingregulationofneuronapoptoticprocessregulationofsignalingreceptoractivitytriglyceridemetabolicprocessamyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessarterymorphogenesiscellularresponsetofattyacidcellularresponsetolow-densitylipoproteinparticlestimuluscholesterolimportcholesteroltransportendocytosishigh-densitylipoproteinparticleclearanceintestinalcholesterolabsorptionlipidmetabolicprocesslipoproteincatabolicprocesslong-termmemorylow-densitylipoproteinparticleclearancenegativeregulationofamyloidfibrilformationnegativeregulationofastrocyteactivationnegativeregulationofgeneexpressionnegativeregulationofmicroglialcellactivationnegativeregulationofproteinmetabolicprocessphagocytosisphospholipidtransportplasmalipoproteinparticleclearancepositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationoflysosomalproteincatabolicprocesspositiveregulationoftriglyceridebiosyntheticprocessreceptor-mediatedendocytosisreceptor-mediatedendocytosisinvolvedincholesteroltransportregulationofcholesterolmetabolicprocessregulationofphosphatidylcholinecatabolicprocessregulationofproteinmetabolicprocessresponsetocaloricrestriction
Cryptochrome-1
412
Period circadian protein homolog 2
1210
7.2
78
0.18
CRY1PER2P97784O54943circadianregulationofgeneexpressioncircadianrhythmDNAdamageinducedproteinphosphorylationentrainmentofcircadianclockbyphotoperiodgluconeogenesisglucosehomeostasislipidstoragenegativeregulationofcircadianrhythmnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofglucocorticoidsecretionnegativeregulationofgluconeogenesisnegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofproteinubiquitinationregulationofcircadianrhythmregulationofDNAdamagecheckpointresponsetoactivityresponsetoglucagonresponsetoinsulinresponsetolightstimuluscircadianregulationoftranslationfattyacidmetabolicprocessglycogenbiosyntheticprocesshistoneH3deacetylationlactatebiosyntheticprocessnegativeregulationofDNA-templatedtranscriptionterminationnegativeregulationoffatcellproliferationnegativeregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationofcold-inducedthermogenesisregulationofcellcycleregulationofglutamateuptakeinvolvedintransmissionofnerveimpulseregulationofinsulinsecretionregulationofneurogenesisregulationofvasoconstrictionresponsetoischemiawhitefatcelldifferentiation
Alpha-crystallin B chain
nan
Alpha-crystallin B chain
nan
3.2
63
0.49
CRYABCRYABP02511P02511apoptoticprocessinvolvedinmorphogenesiscellularresponsetogammaradiationlensdevelopmentincamera-typeeyemicrotubulepolymerizationordepolymerizationmulticellularorganismagingmusclecontractionmuscleorgandevelopmentnegativeregulationofamyloidfibrilformationnegativeregulationofapoptoticprocessnegativeregulationofcellgrowthnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofintracellulartransportnegativeregulationofprotein-containingcomplexassemblynegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationoftranscriptionDNA-templatedproteinfoldingproteinrefoldingproteinstabilizationregulationofcelldeathresponsetoestradiolresponsetoheatresponsetohydrogenperoxideresponsetohypoxiastress-activatedMAPKcascadetubulincomplexassembly
Phospholipase A2, membrane associated
103
Phospholipase A2, membrane associated
79
6.4
78
0.2
PA2GAPA2GAP14555P14555arachidonicacidsecretioncytolysisdefenseresponsetoGram-positivebacteriuminflammatoryresponseintestinalstemcellhomeostasislipidcatabolicprocesslow-densitylipoproteinparticleremodelingphosphatidicacidmetabolicprocessphosphatidylcholinemetabolicprocessphosphatidylethanolaminemetabolicprocessphospholipidmetabolicprocesspositiveregulationofERK1andERK2cascadepositiveregulationofinflammatoryresponsepositiveregulationofmacrophagederivedfoamcelldifferentiationregulationofneutrophilactivation
Ceramide transfer protein
27
Ceramide transfer protein
27
7.9
74
0.17
CERTCERTQ9Y5P4Q9Y5P4cellmorphogenesiscellpopulationproliferationceramidemetabolicprocessceramidetransportendoplasmicreticulumorganizationERtoGolgiceramidetransportheartmorphogenesisimmuneresponseinuteroembryonicdevelopmentintermembranelipidtransferintermembranesphingolipidtransferlipidhomeostasismitochondrionmorphogenesismusclecontractionresponsetoendoplasmicreticulumstresssignaltransduction
Fibrinogen alpha chain
184
Fibrinogen beta chain
227
7.6
71
0.18
FIBAFIBBP02671P02675adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncelladhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulus
Ribonuclease inhibitor
30
Ribonuclease inhibitor
30
8.7
65
0.18
RINIRINIP13489P13489mRNAcatabolicprocessregulationofangiogenesis
Peroxiredoxin-5, mitochondrial
100
Peroxiredoxin-5, mitochondrial
100
8.7
71
0.16
PRDX5PRDX5P30044P30044cellredoxhomeostasiscellularresponsetooxidativestresscellularresponsetoreactiveoxygenspecieshydrogenperoxidecatabolicprocessinflammatoryresponseNADPHoxidationnegativeregulationofapoptoticprocessnegativeregulationofoxidoreductaseactivitynegativeregulationoftranscriptionbyRNApolymeraseIIIpositiveregulationofcollagenbiosyntheticprocessreactivenitrogenspeciesmetabolicprocessregulationofapoptosisinvolvedintissuehomeostasisresponsetooxidativestress
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
305
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
113
7.6
79
0.17
SDHASDHBQ0QF01Q007T0mitochondrialelectrontransportsuccinatetoubiquinonenervoussystemdevelopmentrespiratoryelectrontransportchainsuccinatemetabolicprocesstricarboxylicacidcycle
Nuclear RNA export factor 1
492
NTF2-related export protein 1
132
7.6
88
0.15
NXF1NXT1Q9UBU9Q9UKK6mRNAexportfromnucleuspoly(A)+mRNAexportfromnucleusproteintransportnucleocytoplasmictransportproteinexportfromnucleusproteinimportintonucleus
Probable ubiquitin carboxyl-terminal hydrolase FAF-X
1733
Probable ubiquitin carboxyl-terminal hydrolase FAF-X
1733
7.9
43
0.3
USP9XUSP9XQ93008Q93008amyloidfibrilformationaxonextensionBMPsignalingpathwaycellcyclecelldivisioncellmigrationchromosomesegregationfemalegametegenerationnegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneuronmigrationpositiveregulationofDNAdemethylationpositiveregulationofproteinbindingpositiveregulationofTORC2signalingproteindeubiquitinationproteindeubiquitinationinvolvedinubiquitin-dependentproteincatabolicprocessproteinK63-linkeddeubiquitinationproteinlocalizationproteinstabilizationproteinubiquitinationregulationofcircadianrhythmrhythmicprocesstransforminggrowthfactorbetareceptorsignalingpathway
E3 ubiquitin-protein ligase parkin
337
E3 ubiquitin-protein ligase parkin
323
8.7
69
0.17
PRKNPRKNQ9JK66Q9JK66adultlocomotorybehavioraggresomeassemblyautophagyofmitochondrionbraindevelopmentcellularresponsetohydrogensulfidecellularresponsetoL-glutamatecellularresponsetoL-glutaminecellularresponsetomanganeseioncellularresponsetotoxicsubstancedopaminemetabolicprocessdopamineuptakeinvolvedinsynaptictransmissionfreeubiquitinchainpolymerizationlearninglocomotorybehaviormitochondrialfissionmitochondrialfragmentationinvolvedinapoptoticprocessmitochondrionlocalizationmitochondrionorganizationmitochondriontolysosometransportmitophagymodulationofchemicalsynaptictransmissionnegativeregulationbyhostofviralgenomereplicationnegativeregulationofactinfilamentbundleassemblynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcelldeathnegativeregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofendoplasmicreticulumstress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofexcitatorypostsynapticpotentialnegativeregulationofexosomalsecretionnegativeregulationofgeneexpressionnegativeregulationofglucokinaseactivitynegativeregulationofinsulinsecretionnegativeregulationofintralumenalvesicleformationnegativeregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatornegativeregulationofJNKcascadenegativeregulationofmitochondrialfissionnegativeregulationofmitochondrialfusionnegativeregulationofneuronapoptoticprocessnegativeregulationofneurondeathnegativeregulationofoxidativestress-inducedneurondeathnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofprimaryamineoxidaseactivitynegativeregulationofproteinphosphorylationnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofspontaneousneurotransmittersecretionnegativeregulationofsynaptictransmissionglutamatergicnegativeregulationoftranscriptionbyRNApolymeraseIIneuroncellularhomeostasisnorepinephrinemetabolicprocessparkin-mediatedstimulationofmitophagyinresponsetomitochondrialdepolarizationpositiveregulationofapoptoticprocesspositiveregulationofATPbiosyntheticprocesspositiveregulationofautophagyofmitochondrionpositiveregulationofdendriteextensionpositiveregulationofDNAbindingpositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofmitochondrialfissionpositiveregulationofmitochondrialfusionpositiveregulationofmitochondrialmembranepotentialpositiveregulationofmitophagypositiveregulationofmitophagyinresponsetomitochondrialdepolarizationpositiveregulationofneurotransmitteruptakepositiveregulationofproteasomalproteincatabolicprocesspositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinbindingpositiveregulationofproteinlinearpolyubiquitinationpositiveregulationofproteinlocalizationtomembranepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayproteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautoubiquitinationproteindestabilizationproteinK11-linkedubiquitinationproteinK48-linkedubiquitinationproteinK6-linkedubiquitinationproteinK63-linkedubiquitinationproteinlocalizationtomitochondrionproteinmetabolicprocessproteinmonoubiquitinationproteinpolyubiquitinationproteinstabilizationproteinubiquitinationregulationofapoptoticprocessregulationofautophagyregulationofcellularresponsetooxidativestressregulationofdopaminemetabolicprocessregulationofgeneexpressionregulationofmitochondrialmembranepotentialregulationofmitochondrionorganizationregulationofneurotransmittersecretionregulationofproteinstabilityregulationofproteinubiquitinationregulationofreactiveoxygenspeciesmetabolicprocessresponsetocorticosteroneresponsetocurcuminresponsetoendoplasmicreticulumstressresponsetomuscleactivityresponsetooxidativestressresponsetounfoldedproteinresponsetoxenobioticstimulusstartleresponsesynaptictransmissiondopaminergicsynaptictransmissionglutamatergicubiquitin-dependentproteincatabolicprocesszincionhomeostasis
Chymotrypsinogen A
58
Amyloid-beta precursor protein
300
8.4
97
0.12
CTRAA4P00766P05067digestionproteolysisadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Glucocorticoid receptor
476
Glucocorticoid receptor
482
7.3
66
0.21
GCRGCRP06536P06536adrenalglanddevelopmentagingandrogenmetabolicprocessbraindevelopmentcellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetomagnesiumioncellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinremodelingcircadianrhythmepigeneticmaintenanceofchromatinintranscription-competentconformationfemalepregnancyglucocorticoidmetabolicprocessglucocorticoidreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaylungdevelopmentmammaryglandductmorphogenesismaternalbehaviormuscleatrophynegativeregulationofapoptoticprocessnegativeregulationofsynapticplasticitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationofvascularpermeabilitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofdendriticspinedevelopmentpositiveregulationofglucocorticoidreceptorsignalingpathwaypositiveregulationofglutamatesecretionpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprotein-containingcomplexassemblyregulationofcellpopulationproliferationregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationofglucosemetabolicprocessregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetoactivityresponsetoarsenic-containingsubstanceresponsetocalciumionresponsetocorticosteroneresponsetodexamethasoneresponsetoelectricalstimulusresponsetoinactivityresponsetoinsulinresponsetomercuryionresponsetoradiation
Kallikrein-7
239
Kallikrein-7
137
7.3
72
0.19
KLK7KLK7P49862P49862epidermisdevelopmentextracellularmatrixdisassemblypositiveregulationofantibacterialpeptideproductionproteolysis
C-C motif chemokine 1
34
C-C motif chemokine 1
33
9.6
73
0.14
CCL1CCL1P22362P22362antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiseosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-17productionpositiveregulationofmonocytechemotaxissignaltransductionviralprocess
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
295
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
295
8.7
82
0.14
PAPS1PAPS1O43252O43252"3-phosphoadenosine5-phosphosulfatebiosyntheticprocess"phosphorylationskeletalsystemdevelopmentsulfateassimilation
CDC42BPB protein
36
CDC42BPB protein
41
8.7
73
0.16
Q86XZ8Q86XZ8Q86XZ8Q86XZ8actincytoskeletonorganizationcellmigrationproteinphosphorylation
Neurogenic locus notch homolog protein 3
1488
Neurogenic locus notch homolog protein 3
1488
8.7
90
0.13
NOTC3NOTC3Q9UM47Q9UM47arterymorphogenesisaxonguidanceforebraindevelopmentglomerularcapillaryformationnegativeregulationofneurondifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIneuroblastdifferentiationneuronfatecommitmentNotchsignalingpathwaypositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseII
Mucin-2
1090
Mucin-2
1088
8.4
82
0.15
MUC2MUC2Q02817Q02817maintenanceofgastrointestinalepithelium
MORC family CW-type zinc finger protein 3
413
MORC family CW-type zinc finger protein 3
413
8.7
75
0.15
MORC3MORC3Q14149Q14149innateimmuneresponsemaintenanceofproteinlocationinnucleusnegativeregulationoffibroblastproliferationpeptidyl-serinephosphorylationpositiveregulationofcellularsenescencepost-embryonicdevelopmentproteinphosphorylationproteinstabilization
Growth/differentiation factor 11
372
Growth/differentiation factor 11
371
8.4
81
0.15
GDF11GDF11O95390O95390amacrinecelldifferentiationcamera-typeeyemorphogenesiscellpopulationproliferationmesodermdevelopmentmetanephrosdevelopmentnegativeregulationofamacrinecelldifferentiationnegativeregulationofcellpopulationproliferationnervoussystemdevelopmentpositiveregulationofpathway-restrictedSMADproteinphosphorylationroofofmouthdevelopmentskeletalsystemdevelopmentSMADproteinsignaltransductionspinalcordanterior/posteriorpatterningtypeBpancreaticcellmaturationuretericbuddevelopment
Isovaleryl-CoA dehydrogenase, mitochondrial
370
Isovaleryl-CoA dehydrogenase, mitochondrial
370
8.7
81
0.14
IVDIVDP26440P26440branched-chainaminoacidcatabolicprocessfattyacidbeta-oxidationusingacyl-CoAdehydrogenaseleucinecatabolicprocess
Glycoprotein hormones alpha chain
55
Follitropin subunit beta
102
7.9
70
0.18
GLHAFSHBP01215P01225follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationfemalegametegenerationfemalepregnancypositiveregulationofboneresorptionpositiveregulationofgeneexpressionprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationSertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Mitogen-activated protein kinase 8
220
Mitogen-activated protein kinase 8
220
9.6
72
0.14
MK08MK08P45983P45983cellularresponsetoaminoacidstarvationcellularresponsetocadmiumioncellularresponsetolipopolysaccharidecellularresponsetomechanicalstimuluscellularresponsetooxidativestresscellularresponsetoreactiveoxygenspeciescellularsenescenceFc-epsilonreceptorsignalingpathwayintracellularsignaltransductionJNKcascadeJUNphosphorylationnegativeregulationofapoptoticprocessnegativeregulationofproteinbindingpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofapoptoticprocesspositiveregulationofcellkillingpositiveregulationofcyclaseactivitypositiveregulationofdeacetylaseactivitypositiveregulationofgeneexpressionpositiveregulationofproteininsertionintomitochondrialmembraneinvolvedinapoptoticsignalingpathwaypositiveregulationofproteinmetabolicprocessproteinphosphorylationregulationofcircadianrhythmregulationofDNAreplicationoriginbindingregulationofDNA-bindingtranscriptionfactoractivityregulationofmacroautophagyregulationofproteinlocalizationresponsetomechanicalstimulusresponsetooxidativestressresponsetoUVrhythmicprocessstress-activatedMAPKcascade
Progesterone receptor
609
Progesterone receptor
619
7.6
73
0.18
PRGRPRGRP06401P06401cell-cellsignalingglandularepithelialcellmaturationintracellularsteroidhormonereceptorsignalingpathwaylungalveolusdevelopmentnegativeregulationofgeneexpressionovulationfromovarianfollicleparacrinesignalingpositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronereceptorsignalingpathwayregulationofepithelialcellproliferationregulationoftranscriptionbyRNApolymeraseIIsignaltransductiontertiarybranchinginvolvedinmammaryglandductmorphogenesis
Protein cereblon
329
Protein cereblon
329
7.6
74
0.18
CRBNCRBNQ8C7D2Q8C7D2locomotoryexplorationbehaviornegativeregulationofiontransmembranetransportnegativeregulationoflargeconductancecalcium-activatedpotassiumchannelactivitynegativeregulationofprotein-containingcomplexassemblypositiveregulationofprotein-containingcomplexassemblyproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitination
Trypsin-3
121
Protein AMBP
296
8.6
93
0.13
TRY3AMBPP35030P02760antimicrobialhumoralresponsedigestionendothelialcellmigrationproteolysiszymogenactivationcelladhesioncellularoxidantdetoxificationcellularresponsetoreactiveoxygenspeciescytochromecmetabolicprocessfemalepregnancyhemecatabolicprocesshemoglobinmetabolicprocessnegativeregulationofimmuneresponsenegativeregulationofJNKcascadeproteincatabolicprocess
Phospholipase A2, membrane associated
79
Phospholipase A2, membrane associated
79
7.3
80
0.17
PA2GAPA2GAP14555P14555arachidonicacidsecretioncytolysisdefenseresponsetoGram-positivebacteriuminflammatoryresponseintestinalstemcellhomeostasislipidcatabolicprocesslow-densitylipoproteinparticleremodelingphosphatidicacidmetabolicprocessphosphatidylcholinemetabolicprocessphosphatidylethanolaminemetabolicprocessphospholipidmetabolicprocesspositiveregulationofERK1andERK2cascadepositiveregulationofinflammatoryresponsepositiveregulationofmacrophagederivedfoamcelldifferentiationregulationofneutrophilactivation
Protein PML
91
Protein PML
88
8.4
67
0.18
PMLPMLP29590P29590activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocessbranchinginvolvedinmammaryglandductmorphogenesiscellfatecommitmentcellularresponsetointerleukin-4cellularresponsetoleukemiainhibitoryfactorcellularsenescencecircadianregulationofgeneexpressioncommon-partnerSMADproteinphosphorylationDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestendoplasmicreticulumcalciumionhomeostasisentrainmentofcircadianclockbyphotoperiodextrinsicapoptoticsignalingpathwayfibroblastmigrationinnateimmuneresponseintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressintrinsicapoptoticsignalingpathwayinresponsetooxidativestressmaintenanceofproteinlocationinnucleusmyeloidcelldifferentiationnegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofinterleukin-1betaproductionnegativeregulationofmitoticcellcyclenegativeregulationoftelomeraseactivitynegativeregulationoftelomeremaintenanceviatelomerasenegativeregulationoftranscriptionDNA-templatednegativeregulationoftranslationinresponsetooxidativestressnegativeregulationofubiquitin-dependentproteincatabolicprocessoncogene-inducedcellsenescencePMLbodyorganizationpositiveregulationofapoptoticprocessinvolvedinmammaryglandinvolutionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationoffibroblastproliferationpositiveregulationofhistonedeacetylationpositiveregulationofpeptidyl-lysineacetylationpositiveregulationofproteinlocalizationtochromosometelomericregionpositiveregulationofsignaltransductionbyp53classmediatorpositiveregulationoftelomeremaintenancepositiveregulationoftranscriptionDNA-templatedproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinimportintonucleusproteinstabilizationproteintargetingprotein-containingcomplexassemblyprotein-containingcomplexlocalizationregulationofcalciumiontransportintocytosolregulationofcelladhesionregulationofcellcycleregulationofcircadianrhythmregulationofdouble-strandbreakrepairregulationoftranscriptionDNA-templatedresponsetocytokineresponsetogammaradiationresponsetohypoxiaresponsetoUVretinoicacidreceptorsignalingpathwaysuppressionofviralreleasebyhosttransforminggrowthfactorbetareceptorsignalingpathway
Glycoprotein hormones alpha chain
55
Follitropin subunit beta
102
7.6
76
0.17
Q96QJ4FSHBQ96QJ4P01225femalegametegenerationfemalepregnancyfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwaypositiveregulationofboneresorptionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationregulationofsignalingreceptoractivitySertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Bone morphogenetic protein 6
441
Bone morphogenetic protein 6
477
7.7
84
0.16
BMP6BMP6P22004P22004BMPsignalingpathwaycartilagedevelopmentcellularironionhomeostasiscellularresponsetoBMPstimuluscellularresponsetoironioncellularresponsetomechanicalstimulusendochondralossificationeyedevelopmentimmuneresponseinflammatoryresponsekidneydevelopmentmalegenitaliadevelopmentmulticellularorganismalironionhomeostasisnegativeregulationofadherensjunctionorganizationnegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationoftranscriptionbyRNApolymeraseIIneurondifferentiationosteoblastdifferentiationpositiveregulationofaldosteronebiosyntheticprocesspositiveregulationofaldosteronesecretionpositiveregulationofbonemineralizationpositiveregulationofcellpopulationproliferationpositiveregulationofchondrocytedifferentiationpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofgeneexpressionpositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofneurondifferentiationpositiveregulationofosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinsecretionpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularpermeabilityresponsetoactivityresponsetoglucocorticoidresponsetomagnesiumionresponsetoretinoicacidskeletalsystemdevelopmentSMADproteinsignaltransductiontypeBpancreaticcelldevelopment
Growth/differentiation factor 15
244
Growth/differentiation factor 15
273
7.3
83
0.16
GDF15GDF15Q99988Q99988BMPsignalingpathwaycell-cellsignalingglialcell-derivedneurotrophicfactorreceptorsignalingpathwaynegativeregulationofgrowthhormonereceptorsignalingpathwaynegativeregulationofmulticellularorganismgrowthpositiveregulationofMAPKcascadepositiveregulationofmyoblastfusionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinkinaseBsignalingreductionoffoodintakeinresponsetodietaryexcesssignaltransductionSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Proteasome subunit beta type-7
74
Proteasome subunit beta type-3
129
7.3
72
0.19
PSB7PSB3Q99436P49720proteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocess
Mitochondrial Rho GTPase 2
470
Mitochondrial Rho GTPase 2
470
7.3
79
0.17
MIRO2MIRO2Q8IXI1Q8IXI1cellularhomeostasismitochondrialoutermembranepermeabilizationmitochondrionorganizationmitochondriontransportalongmicrotubuleregulationofmitochondrionorganizationsmallGTPasemediatedsignaltransduction
Calcium/calmodulin-dependent protein kinase type II subunit delta
428
Calcium/calmodulin-dependent protein kinase type II subunit delta
428
8.6
103
0.11
KCC2DKCC2DQ13557Q13557cardiacmusclecellcontractioncellularresponsetocalciumionendoplasmicreticulumcalciumionhomeostasisnegativeregulationofsodiumiontransmembranetransportnegativeregulationofsodiumiontransmembranetransporteractivitypeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcardiacmusclehypertrophyproteinautophosphorylationproteinphosphorylationregulationofcalciumiontransmembranetransportviahighvoltage-gatedcalciumchannelregulationofcardiacmusclecellactionpotentialregulationofcardiacmusclecellactionpotentialinvolvedinregulationofcontractionregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofcellcommunicationbyelectricalcouplingregulationofcellcommunicationbyelectricalcouplinginvolvedincardiacconductionregulationofcellgrowthregulationofcellularlocalizationregulationofheartcontractionregulationofheartratebycardiacconductionregulationofhistonedeacetylaseactivityregulationofmembranedepolarizationregulationofrelaxationofcardiacmuscleregulationofreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumregulationofryanodine-sensitivecalcium-releasechannelactivityregulationoftheforceofheartcontractionregulationoftranscriptionbyRNApolymeraseIIrelaxationofcardiacmuscle
Thioredoxin
69
Thioredoxin
73
7.6
56
0.23
THIOTHIOP10599P10599activationofproteinkinaseBactivitycellredoxhomeostasisnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiation
Mineralocorticoid receptor
645
Mineralocorticoid receptor
655
7.6
73
0.18
MCRMCRP08235P08235intracellularsteroidhormonereceptorsignalingpathwaypositiveregulationofNIK/NF-kappaBsignalingregulationoftranscriptionbyRNApolymeraseIIsignaltransduction
Bone morphogenetic protein 2
361
Bone morphogenetic protein 2
360
8.7
80
0.14
BMP2BMP2P12643P12643ameloblastdifferentiationanimalorganmorphogenesisaorticvalvedevelopmentastrocytedifferentiationatrioventricularcanalmorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwayBMPsignalingpathwayinvolvedinheartdevelopmentBMPsignalingpathwayinvolvedinheartinductionbonemineralizationbonemineralizationinvolvedinbonematurationbranchinginvolvedinuretericbudmorphogenesiscardiacatriumformationcardiacepithelialtomesenchymaltransitioncardiacjellydevelopmentcardiacmusclecelldifferentiationcardiacmuscletissuemorphogenesiscardiocytedifferentiationcellfatecommitmentcell-cellsignalingcellularresponsetoBMPstimuluscellularresponsetoorganiccycliccompoundchondrocytedifferentiationcorticotropinhormonesecretingcelldifferentiationembryonichearttubeanterior/posteriorpatternspecificationendocardialcushionformationendocardialcushionmorphogenesisepithelialtomesenchymaltransitionheartdevelopmentinuteroembryonicdevelopmentinflammatoryresponseinnereardevelopmentmesenchymalcelldifferentiationmesenchymalcellproliferationinvolvedinuretericbuddevelopmentmesenchymedevelopmentnegativeregulationofaldosteronebiosyntheticprocessnegativeregulationofcalcium-independentcell-celladhesionnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcardiacmusclecelldifferentiationnegativeregulationofcellcyclenegativeregulationofcellpopulationproliferationnegativeregulationofcortisolbiosyntheticprocessnegativeregulationofgeneexpressionnegativeregulationofinsulin-likegrowthfactorreceptorsignalingpathwaynegativeregulationofMAPkinaseactivitynegativeregulationofsmoothmusclecellproliferationnegativeregulationofsteroidbiosyntheticprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofWntsignalingpathwayinvolvedinheartdevelopmentNotchsignalingpathwayodontogenesisofdentin-containingtoothosteoblastdifferentiationpathway-restrictedSMADproteinphosphorylationpericardiumdevelopmentpositiveregulationofapoptoticprocesspositiveregulationofastrocytedifferentiationpositiveregulationofbonemineralizationpositiveregulationofcartilagedevelopmentpositiveregulationofcellmigrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcelldifferentiationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixconstituentsecretionpositiveregulationoffatcelldifferentiationpositiveregulationofgeneexpressionpositiveregulationofMAPKcascadepositiveregulationofmiRNAtranscriptionpositiveregulationofneurondifferentiationpositiveregulationofodontogenesispositiveregulationofossificationpositiveregulationofosteoblastdifferentiationpositiveregulationofosteoblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofperoxisomeproliferatoractivatedreceptorsignalingpathwaypositiveregulationofphosphataseactivitypositiveregulationofproteinbindingpositiveregulationofproteinphosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimuluspositiveregulationoftranscriptionDNA-templatedpositiveregulationofWntsignalingpathwaypositiveregulationofWntsignalingpathwaybyBMPsignalingpathwayproteindestabilizationproteinphosphorylationproteoglycanmetabolicprocessregulationofodontogenesisofdentin-containingtoothregulationoftranscriptionDNA-templatedresponsetobacteriumresponsetohypoxiaskeletalsystemdevelopmentSMADproteinsignaltransductiontelencephalondevelopmenttelencephalonregionalizationthyroid-stimulatinghormone-secretingcelldifferentiationtranscriptionbyRNApolymeraseIIWntsignalingpathway
Proteasome subunit beta type-3
129
Proteasome subunit beta type-10
70
8.3
72
0.17
PSB3PSB10P49720P40306proteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocesscellmorphogenesishumoralimmuneresponseTcellproliferation
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
279
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
279
7.9
99
0.13
ODB2ODB2P11181P11181branched-chainaminoacidcatabolicprocess
Serine protease 1
64
Pancreatic trypsin inhibitor
49
8.6
95
0.12
TRY1BPT1P07477P00974digestionextracellularmatrixdisassemblyproteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Bone morphogenetic protein 3
403
Bone morphogenetic protein 3
436
7.9
85
0.15
BMP3BMP3P12645P12645cartilagedevelopmentcell-cellsignalingosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationskeletalsystemdevelopmentSMADproteinsignaltransduction
Oxytocin-neurophysin 1
110
Oxytocin-neurophysin 1
110
7.9
100
0.13
NEU1NEU1P01175P01175positiveregulationofcold-inducedthermogenesisresponsetoestrogenresponsetoexternalbioticstimulusresponsetofoodresponsetomechanicalstimulus
E3 ubiquitin-protein ligase RNF13
278
E3 ubiquitin-protein ligase RNF13
266
7.9
74
0.17
RNF13RNF13O43567O43567organellelocalizationpositiveregulationofstress-activatedproteinkinasesignalingcascadeproteinautoubiquitinationubiquitin-dependentproteincatabolicprocess
Adrenodoxin, mitochondrial
112
Adrenodoxin, mitochondrial
112
8.4
90
0.13
ADXADXP10109P10109cellularresponsetocAMPcellularresponsetoforskolincholesterolmetabolicprocesselectrontransportchainhormonebiosyntheticprocessP450-containingelectrontransportchainpositiveregulationofoxidoreductaseactivitysteroidbiosyntheticprocess
Growth/differentiation factor 2
392
Growth/differentiation factor 2
360
8.4
83
0.14
GDF2GDF2Q9UK05Q9UK05activinreceptorsignalingpathwayangiogenesisbloodvesselmorphogenesisBMPsignalingpathwaybranchinginvolvedinbloodvesselmorphogenesiscartilagedevelopmentcellularironionhomeostasiscellularresponsetoBMPstimulusnegativeregulationofangiogenesisnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellgrowthnegativeregulationofDNAbiosyntheticprocessnegativeregulationofDNAreplicationnegativeregulationofendothelialcellmigrationnegativeregulationofendothelialcellproliferationossificationosteoblastdifferentiationpathway-restrictedSMADproteinphosphorylationpositiveregulationofangiogenesispositiveregulationofBMPsignalingpathwaypositiveregulationofcartilagedevelopmentpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofinterleukin-8productionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedSMADproteinsignaltransductiontranscriptionbyRNApolymeraseIIvasculogenesis
Serine protease 1
64
Amyloid-beta precursor protein
300
8.4
97
0.12
TRY1A4P00760P05067digestionproteolysisadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Glucocorticoid receptor
482
Glucocorticoid receptor
492
8.4
71
0.17
GCRGCRP06536P06536adrenalglanddevelopmentagingandrogenmetabolicprocessbraindevelopmentcellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetomagnesiumioncellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinremodelingcircadianrhythmepigeneticmaintenanceofchromatinintranscription-competentconformationfemalepregnancyglucocorticoidmetabolicprocessglucocorticoidreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaylungdevelopmentmammaryglandductmorphogenesismaternalbehaviormuscleatrophynegativeregulationofapoptoticprocessnegativeregulationofsynapticplasticitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationofvascularpermeabilitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofdendriticspinedevelopmentpositiveregulationofglucocorticoidreceptorsignalingpathwaypositiveregulationofglutamatesecretionpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprotein-containingcomplexassemblyregulationofcellpopulationproliferationregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationofglucosemetabolicprocessregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetoactivityresponsetoarsenic-containingsubstanceresponsetocalciumionresponsetocorticosteroneresponsetodexamethasoneresponsetoelectricalstimulusresponsetoinactivityresponsetoinsulinresponsetomercuryionresponsetoradiation
Zinc finger MYND domain-containing protein 11
535
Zinc finger MYND domain-containing protein 11
535
7.3
43
0.32
ZMY11ZMY11Q15326Q15326cellcyclechromatinorganizationdefenseresponsetovirusnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofJNKcascadenegativeregulationoftranscriptionDNA-templatedregulationofsignaltransductionregulationoftranscriptionelongationfromRNApolymeraseIIpromoter
Thioredoxin
35
Thioredoxin
62
7.3
68
0.2
THIOTHIOP10599P10599activationofproteinkinaseBactivitycellredoxhomeostasisnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiation
Complement C5
1159
Complement C5
1159
7.3
73
0.19
CO5CO5P01031P01031cellsurfacereceptorsignalingpathwaychemotaxiscomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisGprotein-coupledreceptorsignalingpathwayinuteroembryonicdevelopmentinflammatoryresponsenegativeregulationofmacrophagechemotaxispositiveregulationofangiogenesispositiveregulationofchemokineproductionpositiveregulationofimmuneresponsepositiveregulationofvascularendothelialgrowthfactorproduction
Coagulation factor XIII A chain
424
Coagulation factor XIII A chain
424
7.9
72
0.18
F13AF13AP00488P00488bloodcoagulationbloodcoagulationfibrinclotformationpeptidecross-linking
Corticotropin-releasing factor receptor 1
128
Corticotropin-releasing factor receptor 1
128
7.9
66
0.19
CRFR1CRFR1P34998P34998activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwayadrenalglanddevelopmentbehavioralresponsetoethanolcellsurfacereceptorsignalingpathwaycellularresponsetocorticotropin-releasinghormonestimuluscorticotropinsecretionfearresponsefemalepregnancygeneraladaptationsyndromebehavioralprocessimmuneresponsenegativeregulationofvoltage-gatedcalciumchannelactivityparturitionregulationofadenylatecyclaseactivityinvolvedinGprotein-coupledreceptorsignalingpathwayregulationofcorticosteronesecretion
C-C motif chemokine 3
57
C-C motif chemokine 3
57
7.9
57
0.22
CCL3CCL3P10147P10147astrocytecellmigrationcalciumiontransportcalcium-mediatedsignalingcellactivationcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytoskeletonorganizationeosinophilchemotaxiseosinophildegranulationexocytosisGprotein-coupledreceptorsignalingpathwaygranulocytechemotaxisinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofosteoclastdifferentiationneutrophilchemotaxisosteoblastdifferentiationpositiveregulationofcalciumionimportpositiveregulationofcalciumiontransportpositiveregulationofcalcium-mediatedsignalingpositiveregulationofcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofmicroglialcellactivationpositiveregulationofmicroglialcellmigrationpositiveregulationofnaturalkillercellchemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofproteinkinaseBsignalingpositiveregulationoftumornecrosisfactorproductionproteinkinaseBsignalingregulationofbehaviorregulationofcellshaperegulationofsensoryperceptionofpainreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolresponsetotoxicsubstancesignalingTcellchemotaxis
Growth factor receptor-bound protein 7
527
Growth factor receptor-bound protein 7
527
8.4
75
0.16
GRB7GRB7Q14451Q14451epidermalgrowthfactorreceptorsignalingpathwaynegativeregulationoftranslationpositiveregulationofcellmigrationstressgranuleassembly
Malate dehydrogenase, cytoplasmic
251
Malate dehydrogenase, cytoplasmic
60
9.6
79
0.13
MDHCMDHCP40925P40925malatemetabolicprocessNADHmetabolicprocessNADPmetabolicprocessoxaloacetatemetabolicprocesstricarboxylicacidcycle
Complement C5
704
Complement C5
711
7.9
73
0.17
CO5CO5P01031P01031cellsurfacereceptorsignalingpathwaychemotaxiscomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisGprotein-coupledreceptorsignalingpathwayinuteroembryonicdevelopmentinflammatoryresponsenegativeregulationofmacrophagechemotaxispositiveregulationofangiogenesispositiveregulationofchemokineproductionpositiveregulationofimmuneresponsepositiveregulationofvascularendothelialgrowthfactorproduction
BRISC and BRCA1-A complex member 2
307
BRISC and BRCA1-A complex member 1
298
9.6
75
0.14
BABA2BABA1Q8K3W0Q3UI43apoptoticprocesscelldivisioncellularresponsetoDNAdamagestimuluscellularresponsetoionizingradiationchromatinorganizationdouble-strandbreakrepairhistoneH2AK63-linkeddeubiquitinationhistoneH2AmonoubiquitinationmitoticG2DNAdamagecheckpointsignalingmitoticG2/MtransitioncheckpointnegativeregulationofapoptoticprocesspositiveregulationofDNArepairproteinautoubiquitinationregulationofDNAdamagecheckpointregulationofDNArepairresponsetoionizingradiationhematopoieticstemcellproliferationproteinK63-linkeddeubiquitination
Glucocorticoid receptor
457
Glucocorticoid receptor
457
9.6
64
0.16
GCRGCRP79269P79269cellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluschromatinorganizationpositiveregulationoftranscriptionbyRNApolymeraseII
Dihydropyrimidinase-related protein 2
323
Dihydropyrimidinase-related protein 2
323
9.6
79
0.13
DPYL2DPYL2O08553O08553axonguidancebraindevelopmentcytoskeletonorganizationendocytosispositiveregulationofglutamatesecretionregulationofaxonextensionregulationofneurondifferentiationregulationofneuronprojectiondevelopmentsynapticvesicletransport
Histone-lysine N-methyltransferase 2C
1081
Histone-lysine N-methyltransferase 2C
1078
7.3
72
0.19
KMT2CKMT2CQ8NEZ4Q8NEZ4chromatinorganizationhistoneH3-K4methylationhistoneH3-K4monomethylationpositiveregulationoftranscriptionbyRNApolymeraseII
MIT domain-containing protein 1
226
MIT domain-containing protein 1
226
7.3
63
0.22
MITD1MITD1Q8WV92Q8WV92midbodyabscissionmitoticcytokinesisnegativeregulationofproteinbinding
Caspase-8
313
Caspase-8
426
7.3
84
0.16
CASP8CASP8Q14790Q14790activationofcysteine-typeendopeptidaseactivityactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessangiogenesisapoptoticprocessapoptoticsignalingpathwayBcellactivationcellularresponsetomechanicalstimuluscellularresponsetoorganiccycliccompoundexecutionphaseofapoptosisextrinsicapoptoticsignalingpathwayextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsheartdevelopmentmacrophagedifferentiationnaturalkillercellactivationnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofnecroptoticprocesspositiveregulationofapoptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-1betaproductionpositiveregulationofmacrophagedifferentiationpositiveregulationofneurondeathpositiveregulationofproteolysisproteolysisproteolysisinvolvedinproteincatabolicprocesspyroptosisregulationofcytokineproductionregulationofinnateimmuneresponseregulationoftumornecrosisfactor-mediatedsignalingpathwayresponsetoantibioticresponsetocobaltionresponsetocoldresponsetoestradiolresponsetoethanolresponsetolipopolysaccharideresponsetotumornecrosisfactorselfproteolysissyncytiotrophoblastcelldifferentiationinvolvedinlabyrinthinelayerdevelopmentTcellactivationTRAIL-activatedapoptoticsignalingpathway
C-C motif chemokine 14
59
C-C motif chemokine 14
59
7.9
52
0.24
CCL14CCL14Q16627Q16627cellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwayGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
Transforming growth factor beta-3 proprotein
377
Transforming growth factor beta-3 proprotein
315
8.4
83
0.14
TGFB3TGFB3P10600P10600agingBMPsignalingpathwaycell-celljunctionorganizationdetectionofhypoxiadigestivetractdevelopmentembryonicneurocraniummorphogenesisfacemorphogenesisfemalepregnancyfrontalsuturemorphogenesisinuteroembryonicdevelopmentinnereardevelopmentlungalveolusdevelopmentmammaryglanddevelopmentnegativeregulationofcellpopulationproliferationnegativeregulationofmacrophagecytokineproductionnegativeregulationofneuronapoptoticprocessnegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofvascularassociatedsmoothmusclecellproliferationodontogenesisossificationinvolvedinboneremodelingpositiveregulationofapoptoticprocesspositiveregulationofbonemineralizationpositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationoffilopodiumassemblypositiveregulationofMAPKcascadepositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofSMADproteinsignaltransductionpositiveregulationofstressfiberassemblypositiveregulationoftightjunctiondisassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofcellpopulationproliferationresponsetoestrogenresponsetohypoxiaresponsetolaminarfluidshearstressresponsetoprogesteronesalivaryglandmorphogenesissecondarypalatedevelopmentSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwayuterinewallbreakdownwoundhealing
Ankyrin repeat and SOCS box protein 9
262
Elongin-C
112
8.7
nan
nan
ASB9ELOCQ96DX5Q15369intracellularsignaltransductionpositiveregulationofproteincatabolicprocessproteinubiquitinationregulationoftranscriptionbyRNApolymeraseIItranscriptioninitiationfromRNApolymeraseIIpromoterubiquitin-dependentproteincatabolicprocess
Growth/differentiation factor 2
356
Growth/differentiation factor 2
392
8.7
81
0.14
GDF2GDF2Q9UK05Q9UK05activinreceptorsignalingpathwayangiogenesisbloodvesselmorphogenesisBMPsignalingpathwaybranchinginvolvedinbloodvesselmorphogenesiscartilagedevelopmentcellularironionhomeostasiscellularresponsetoBMPstimulusnegativeregulationofangiogenesisnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellgrowthnegativeregulationofDNAbiosyntheticprocessnegativeregulationofDNAreplicationnegativeregulationofendothelialcellmigrationnegativeregulationofendothelialcellproliferationossificationosteoblastdifferentiationpathway-restrictedSMADproteinphosphorylationpositiveregulationofangiogenesispositiveregulationofBMPsignalingpathwaypositiveregulationofcartilagedevelopmentpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofinterleukin-8productionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedSMADproteinsignaltransductiontranscriptionbyRNApolymeraseIIvasculogenesis
A disintegrin and metalloproteinase with thrombospondin motifs 5
376
A disintegrin and metalloproteinase with thrombospondin motifs 5
394
8.7
74
0.15
ATS5ATS5Q9UNA0Q9UNA0defenseresponsetobacteriumextracellularmatrixdisassemblyextracellularmatrixorganizationmyoblastfusionnegativeregulationofcold-inducedthermogenesisproteolysistootheruption
Endothelin-1
63
Endothelin-1
63
8.4
52
0.23
EDN1EDN1P05305P05305adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayarterysmoothmusclecontractionaxonextensionaxonogenesisinvolvedininnervationbodyfluidsecretionbranchinginvolvedinbloodvesselmorphogenesiscalciumiontransmembranetransportcalcium-mediatedsignalingcanonicalWntsignalingpathwaycardiacneuralcrestcellmigrationinvolvedinoutflowtractmorphogenesiscartilagedevelopmentcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularcalciumionhomeostasiscellularresponsetocalciumioncellularresponsetofattyacidcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetohumanchorionicgonadotropinstimuluscellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoluteinizinghormonestimuluscellularresponsetomineralocorticoidstimuluscellularresponsetoorganicsubstancecellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetotumornecrosisfactorcellularresponsetoxenobioticstimulusdorsal/ventralpatternformationembryonichearttubedevelopmentendothelinreceptorsignalingpathwayendothelinreceptorsignalingpathwayinvolvedinheartprocessepithelialfluidtransportERK1andERK2cascadeGprotein-coupledreceptorsignalingpathwayhistaminesecretionI-kappaBkinase/NF-kappaBsignalinginuteroembryonicdevelopmentinositolphosphate-mediatedsignalingleukocyteactivationmaternalprocessinvolvedinparturitionmeioticcellcycleprocessinvolvedinoocytematurationmembranedepolarizationmiddleearmorphogenesismitochondrionorganizationmulticellularorganismagingnegativeregulationofbloodcoagulationnegativeregulationofgeneexpressionnegativeregulationofhormonesecretionnegativeregulationofnitric-oxidesynthasebiosyntheticprocessnegativeregulationofproteinmetabolicprocessnegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneuralcrestcellfatecommitmentnitricoxidetransportnoradrenergicneurondifferentiationpeptidehormonesecretionpharyngealarcharterymorphogenesisphosphatidylinositol3-kinasesignalingphospholipaseD-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcardiacmusclehypertrophypositiveregulationofcationchannelactivitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellsizepositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellmigrationpositiveregulationofheartratepositiveregulationofhormonesecretionpositiveregulationofJUNkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofmitoticnucleardivisionpositiveregulationofneutrophilchemotaxispositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofodontogenesispositiveregulationofprostaglandinsecretionpositiveregulationofprostaglandin-endoperoxidesynthaseactivitypositiveregulationofrenalsodiumexcretionpositiveregulationofsarcomereorganizationpositiveregulationofsignalingreceptoractivitypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsmoothmusclecontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofurinevolumepositiveregulationofvascularassociatedsmoothmusclecellproliferationprostaglandinbiosyntheticprocessproteinkinaseAsignalingproteinkinaseCdeactivationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteinphosphorylationregulationofglucosetransmembranetransportregulationofpHregulationofsensoryperceptionofpainregulationofsystemicarterialbloodpressurebyendothelinregulationofvasoconstrictionrenalsodiumionabsorptionrespiratorygaseousexchangebyrespiratorysystemresponsetoactivityresponsetoaminoacidresponsetoamphetamineresponsetodexamethasoneresponsetoleptinresponsetolipopolysaccharideresponsetomusclestretchresponsetonicotineresponsetoozoneresponsetoprostaglandinFresponsetosaltresponsetotestosteronerhythmicexcitationsemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesensoryperceptionofpainsuperoxideaniongenerationsympatheticneuronaxonguidancethyroidglanddevelopmenttranscriptionbyRNApolymeraseIIvasoconstrictionveinsmoothmusclecontraction
Protein S100-A5
80
Protein S100-A5
80
8.4
72
0.16
S10A5S10A5P33763P33763
Fibrinogen alpha chain
64
Fibrinogen gamma chain
45
7.3
91
0.15
FIBAFIBGP02671P02679adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-1cellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
C-C motif chemokine 4
58
C-C motif chemokine 4
58
8.4
58
0.2
CCL4CCL4P13236P13236celladhesioncell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwayeosinophilchemotaxisestablishmentormaintenanceofcellpolarityGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponselymphocytechemotaxismonocytechemotaxisnegativeregulationbyhostofviraltranscriptionneutrophilchemotaxispositiveregulationofcalciumiontransportpositiveregulationofcalcium-mediatedsignalingpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofnaturalkillercellchemotaxisresponsetotoxicsubstanceresponsetovirussignaltransduction
Acyloxyacyl hydrolase
41
Acyloxyacyl hydrolase
453
8.4
71
0.17
AOAHAOAHP28039P28039fattyacidmetabolicprocesslipopolysaccharidecatabolicprocessnegativeregulationofinflammatoryresponse
Pantothenate kinase 2, mitochondrial
508
Pantothenate kinase 2, mitochondrial
508
9.6
77
0.13
PANK2PANK2Q9BZ23Q9BZ23aerobicrespirationangiogenesiscoenzymeAbiosyntheticprocessmitochondrionmorphogenesispantothenatemetabolicprocessphosphorylationregulationofbileacidmetabolicprocessregulationoffattyacidmetabolicprocessregulationofmitochondrialmembranepotentialregulationoftriglyceridemetabolicprocessspermatiddevelopment
Glycoprotein hormones alpha chain
83
Follitropin subunit beta
50
8.4
83
0.14
Q96QJ4FSHBQ96QJ4P01225femalegametegenerationfemalepregnancyfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwaypositiveregulationofboneresorptionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationregulationofsignalingreceptoractivitySertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Vascular endothelial growth factor B
72
Vascular endothelial growth factor B
82
8.8
78
0.15
VEGFBVEGFBP49765P49765cardiacmusclecontractioncoronaryvasculaturedevelopmentinductionofpositivechemotaxisnegativeregulationofapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofneuronapoptoticprocesspositiveregulationofangiogenesispositiveregulationofcelldivisionpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofmastcellchemotaxispositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofvascularwoundhealingproteinO-linkedglycosylationresponsetohypoxiasproutingangiogenesisvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathway
Vascular endothelial growth factor B
72
Vascular endothelial growth factor B
89
8.8
65
0.18
VEGFBVEGFBP49765P49765cardiacmusclecontractioncoronaryvasculaturedevelopmentinductionofpositivechemotaxisnegativeregulationofapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofneuronapoptoticprocesspositiveregulationofangiogenesispositiveregulationofcelldivisionpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofmastcellchemotaxispositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofvascularwoundhealingproteinO-linkedglycosylationresponsetohypoxiasproutingangiogenesisvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathway
Isoform L-VEGF206 of Vascular endothelial growth factor A
257
Isoform L-VEGF206 of Vascular endothelial growth factor A
267
8.6
68
0.17
VEGFAVEGFAP15692-14P15692-14
Serine/threonine-protein kinase Nek1
175
Serine/threonine-protein kinase Nek1
276
7.6
76
0.17
NEK1NEK1Q96PY6Q96PY6cellcyclecelldivisionciliumassemblyproteinphosphorylation
Resistin-like beta
102
Resistin-like beta
102
7.6
74
0.18
RETNBRETNBQ99P86Q99P86responsetobacterium
Transforming growth factor beta-3 proprotein
348
Transforming growth factor beta-3 proprotein
377
7.6
80
0.16
TGFB3TGFB3P10600P10600agingBMPsignalingpathwaycell-celljunctionorganizationdetectionofhypoxiadigestivetractdevelopmentembryonicneurocraniummorphogenesisfacemorphogenesisfemalepregnancyfrontalsuturemorphogenesisinuteroembryonicdevelopmentinnereardevelopmentlungalveolusdevelopmentmammaryglanddevelopmentnegativeregulationofcellpopulationproliferationnegativeregulationofmacrophagecytokineproductionnegativeregulationofneuronapoptoticprocessnegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofvascularassociatedsmoothmusclecellproliferationodontogenesisossificationinvolvedinboneremodelingpositiveregulationofapoptoticprocesspositiveregulationofbonemineralizationpositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationoffilopodiumassemblypositiveregulationofMAPKcascadepositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofSMADproteinsignaltransductionpositiveregulationofstressfiberassemblypositiveregulationoftightjunctiondisassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofcellpopulationproliferationresponsetoestrogenresponsetohypoxiaresponsetolaminarfluidshearstressresponsetoprogesteronesalivaryglandmorphogenesissecondarypalatedevelopmentSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwayuterinewallbreakdownwoundhealing
Defensin beta 4A
38
Defensin beta 4A
53
7.2
93
0.15
DFB4ADFB4AO15263O15263antifungalinnateimmuneresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellchemotaxischemotaxisdefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponsekillingofcellsofanotherorganismmembranedisruptioninanotherorganism
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
305
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
93
8.6
83
0.14
SDHASDHBQ0QF01Q007T0mitochondrialelectrontransportsuccinatetoubiquinonenervoussystemdevelopmentrespiratoryelectrontransportchainsuccinatemetabolicprocesstricarboxylicacidcycle
Secreted frizzled-related protein 3
147
Secreted frizzled-related protein 3
147
8.8
86
0.13
SFRP3SFRP3P97401P97401canonicalWntsignalingpathwaycochleamorphogenesisconvergentextensioninvolvedinorganogenesisepithelialcelldevelopmenthepatocytedifferentiationinnerearmorphogenesisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcartilagedevelopmentnegativeregulationofcelldevelopmentnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofhepatocytedifferentiationnegativeregulationofWntsignalingpathwayneuralcrestcelldifferentiationpositiveregulationofapoptoticprocesspositiveregulationoffatcelldifferentiationsomitedevelopment
Acyl-protein thioesterase 1
173
Acyl-protein thioesterase 1
173
8.6
56
0.21
LYPA1LYPA1O75608O75608fattyacidmetabolicprocessnegativeregulationofGolgitoplasmamembraneproteintransportproteindepalmitoylation
Lysozyme C
127
Lysozyme C
127
7.6
67
0.2
LYSCLYSCP11375P11375cytolysisdefenseresponsetobacteriummetabolicprocess
cAMP-dependent protein kinase type I-beta regulatory subunit
34
cAMP-dependent protein kinase type I-beta regulatory subunit
34
7.6
60
0.22
KAP1KAP1P31321P31321learningormemorynegativeregulationofcAMP-dependentproteinkinaseactivitypositiveregulationofexcitatorypostsynapticpotentialpositiveregulationoffearresponsepositiveregulationoflong-termsynapticpotentiationpositiveregulationofsensoryperceptionofpainproteinphosphorylationregulationofsynapticvesiclecycle
MORC family CW-type zinc finger protein 3
416
MORC family CW-type zinc finger protein 3
446
7.2
69
0.2
MORC3MORC3Q14149Q14149innateimmuneresponsemaintenanceofproteinlocationinnucleusnegativeregulationoffibroblastproliferationpeptidyl-serinephosphorylationpositiveregulationofcellularsenescencepost-embryonicdevelopmentproteinphosphorylationproteinstabilization
Bone morphogenetic protein 6
477
Bone morphogenetic protein 6
445
7.2
82
0.17
BMP6BMP6P22004P22004BMPsignalingpathwaycartilagedevelopmentcellularironionhomeostasiscellularresponsetoBMPstimuluscellularresponsetoironioncellularresponsetomechanicalstimulusendochondralossificationeyedevelopmentimmuneresponseinflammatoryresponsekidneydevelopmentmalegenitaliadevelopmentmulticellularorganismalironionhomeostasisnegativeregulationofadherensjunctionorganizationnegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationoftranscriptionbyRNApolymeraseIIneurondifferentiationosteoblastdifferentiationpositiveregulationofaldosteronebiosyntheticprocesspositiveregulationofaldosteronesecretionpositiveregulationofbonemineralizationpositiveregulationofcellpopulationproliferationpositiveregulationofchondrocytedifferentiationpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofgeneexpressionpositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofneurondifferentiationpositiveregulationofosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinsecretionpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularpermeabilityresponsetoactivityresponsetoglucocorticoidresponsetomagnesiumionresponsetoretinoicacidskeletalsystemdevelopmentSMADproteinsignaltransductiontypeBpancreaticcelldevelopment
Ig gamma-2A chain C region, A allele
110
Ig gamma-2A chain C region, A allele
112
7.6
29
0.45
GCAAGCAAP01863P01863BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationresponsetobacterium
NAD-capped RNA hydrolase NUDT12
387
NAD-capped RNA hydrolase NUDT12
400
8.8
74
0.15
NUD12NUD12Q9DCN1Q9DCN1circadianregulationofgeneexpressionmethylguanosine-capdecappingmRNAcatabolicprocessNADcatabolicprocessNAD-capdecappingNADHmetabolicprocessNADPcatabolicprocess
Platelet-derived growth factor subunit A
123
Platelet-derived growth factor subunit A
133
8.6
74
0.16
PDGFAPDGFAP04085P04085actincytoskeletonorganizationangiogenesisanimalorganmorphogenesiscellactivationcellprojectionassemblycell-cellsignalingcellularresponsetotransforminggrowthfactorbetastimulusembryoniclungdevelopmenthairfollicledevelopmentinnereardevelopmentlungalveolusdevelopmentmalegonaddevelopmentnegativechemotaxisnegativeregulationofphosphatidylinositolbiosyntheticprocessnegativeregulationofplateletactivationplatelet-derivedgrowthfactorreceptorsignalingpathwayplatelet-derivedgrowthfactorreceptor-alphasignalingpathwaypositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmesenchymalcellproliferationpositiveregulationofmetanephricmesenchymalcellmigrationbyplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingregulationofactincytoskeletonorganizationregulationofbranchinginvolvedinsalivaryglandmorphogenesisbyepithelial-mesenchymalsignalingregulationofpeptidyl-tyrosinephosphorylationregulationofsmoothmusclecellmigrationresponsetoestradiolresponsetohypoxiaresponsetoinorganicsubstanceresponsetoretinoicacidresponsetowoundingresponsetoxenobioticstimulusskindevelopmentwoundhealing
Protein cereblon
397
Protein cereblon
329
7.7
67
0.19
CRBNCRBNQ8C7D2Q8C7D2locomotoryexplorationbehaviornegativeregulationofiontransmembranetransportnegativeregulationoflargeconductancecalcium-activatedpotassiumchannelactivitynegativeregulationofprotein-containingcomplexassemblypositiveregulationofprotein-containingcomplexassemblyproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitination
Putative methyltransferase C9orf114
343
Putative methyltransferase C9orf114
108
7.3
87
0.16
CI114CI114Q5T280Q5T280cellcyclecelldivisionmaintenanceofcentrosomelocationmethylationmiRNAprocessingpost-transcriptionalregulationofgeneexpression
E3 ubiquitin-protein ligase UHRF1
344
E3 ubiquitin-protein ligase UHRF1
321
8.7
63
0.18
UHRF1UHRF1Q96T88Q96T88cellcyclechromatinorganizationDNArepairhistonemonoubiquitinationhistoneubiquitinationmaintenanceofDNAmethylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAtopoisomerase(ATP-hydrolyzing)activitypositiveregulationofproteinmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIproteinautoubiquitinationproteinubiquitinationregulationofepithelialcellproliferationubiquitin-dependentproteincatabolicprocess
Glycoprotein hormones alpha chain
55
Follitropin subunit beta
50
7.7
78
0.17
Q96QJ4FSHBQ96QJ4P01225femalegametegenerationfemalepregnancyfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwaypositiveregulationofboneresorptionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationregulationofsignalingreceptoractivitySertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Lectin-related NK cell receptor LY49L4
153
Lectin-related NK cell receptor LY49L4
153
8.7
64
0.18
Q9JIP9Q9JIP9Q9JIP9Q9JIP9
Glycoprotein hormones alpha chain
55
Follitropin subunit beta
50
7.7
72
0.18
GLHAFSHBP01215P01225follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationfemalegametegenerationfemalepregnancypositiveregulationofboneresorptionpositiveregulationofgeneexpressionprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationSertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Growth/differentiation factor 15
273
Growth/differentiation factor 15
274
8.6
83
0.14
GDF15GDF15Q99988Q99988BMPsignalingpathwaycell-cellsignalingglialcell-derivedneurotrophicfactorreceptorsignalingpathwaynegativeregulationofgrowthhormonereceptorsignalingpathwaynegativeregulationofmulticellularorganismgrowthpositiveregulationofMAPKcascadepositiveregulationofmyoblastfusionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinkinaseBsignalingreductionoffoodintakeinresponsetodietaryexcesssignaltransductionSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Protein disulfide-isomerase
397
Microsomal triglyceride transfer protein large subunit
866
7.7
72
0.18
PDIA1MTPP07237P55157cellularresponsetohypoxiacellularresponsetointerleukin-7interleukin-12-mediatedsignalingpathwayinterleukin-23-mediatedsignalingpathwaypeptidyl-prolinehydroxylationto4-hydroxy-L-prolinepositiveregulationofcelladhesionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofviralentryintohostcellproteinfoldingproteinfoldinginendoplasmicreticulumregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwayresponsetoendoplasmicreticulumstresscholesterolhomeostasischylomicronassemblycircadianrhythmestablishmentoflocalizationincelllipidmetabolicprocesslipoproteinmetabolicprocesslipoproteintransportlow-densitylipoproteinparticleremodelingphospholipidtransportplasmalipoproteinparticleassemblyproteinlipidationproteinsecretionresponsetocalciumiontriglyceridemetabolicprocesstriglyceridetransportvery-low-densitylipoproteinparticleassembly
Bone morphogenetic protein 10
388
Bone morphogenetic protein 10
356
8.5
79
0.15
BMP10BMP10O95393O95393activinreceptorsignalingpathwayadultheartdevelopmentatrialcardiacmuscletissuemorphogenesisBMPsignalingpathwaycardiacmusclecellproliferationcelladhesionhearttrabeculaformationkidneydevelopmentnegativeregulationofcardiacmusclehypertrophynegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofendothelialcellmigrationpathway-restrictedSMADproteinphosphorylationpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcardiacmusclehypertrophypositiveregulationofcartilagedevelopmentpositiveregulationofcellproliferationinvolvedinheartmorphogenesispositiveregulationofgeneexpressionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofsarcomereorganizationpositiveregulationoftranscriptionDNA-templatedregulationofcardiacmusclecontractionregulationofcardiacmusclehypertrophyinresponsetostresssarcomereorganizationSMADproteinsignaltransductionventricularcardiacmusclecelldevelopmentventricularcardiacmuscletissuemorphogenesis
Peroxisomal multifunctional enzyme type 2
230
Peroxisomal multifunctional enzyme type 2
277
8.6
59
0.2
DHB4DHB4P97852P97852agingandrogenmetabolicprocesscellularresponsetoorganiccycliccompoundcholesterolmetabolicprocessestrogenmetabolicprocessfattyacidbeta-oxidationmedium-chainfatty-acyl-CoAmetabolicprocessresponsetoorganiccycliccompoundresponsetosteroidhormoneresponsetoxenobioticstimulusSertolicelldevelopmentverylong-chainfattyacidmetabolicprocessverylong-chainfatty-acyl-CoAmetabolicprocess
Interleukin enhancer-binding factor 2
37
Interleukin enhancer-binding factor 3
278
7.7
75
0.17
ILF2ILF3Q9CXY6Q9Z1X4positiveregulationoftranscriptionDNA-templateddefenseresponsetovirusnegativeregulationoftranscriptionDNA-templatednegativeregulationoftranslationnegativeregulationofviralgenomereplicationproteinmethylationproteinphosphorylation
Calcium/calmodulin-dependent protein kinase type II subunit alpha
428
Calcium/calmodulin-dependent protein kinase type II subunit alpha
428
7.2
104
0.13
KCC2AKCC2AP11798P11798angiotensin-activatedsignalingpathwaycalciumiontransportcalmodulindependentkinasesignalingpathwaydendritemorphogenesisdendriticspinedevelopmentG1/StransitionofmitoticcellcycleionotropicglutamatereceptorsignalingpathwaynegativeregulationofhydrolaseactivityNMDAselectiveglutamatereceptorsignalingpathwaypeptidyl-serinephosphorylationpeptidyl-threonineautophosphorylationpositiveregulationofcalciumiontransportpositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofNF-kappaBtranscriptionfactoractivitypostsynapticneurotransmitterreceptordiffusiontrappingproteinautophosphorylationproteinphosphorylationregulationofendocannabinoidsignalingpathwayregulationofmitochondrialmembranepermeabilityinvolvedinapoptoticprocessregulationofneuronmigrationregulationofneuronalsynapticplasticityregulationofneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneregulationofneurotransmittersecretionregulationofproteinlocalizationtoplasmamembraneregulationofsynapticvesicledockingresponsetoischemia
Adrenodoxin, mitochondrial
104
Adrenodoxin, mitochondrial
110
8.4
82
0.15
ADXADXP00257P00257cellularresponsetocAMPcellularresponsetoforskolincholesterolmetabolicprocesselectrontransportchainhormonebiosyntheticprocessP450-containingelectrontransportchainpositiveregulationofoxidoreductaseactivityrespiratoryelectrontransportchainsteroidbiosyntheticprocess
Cryptochrome-2
432
F-box/LRR-repeat protein 3
340
8.3
87
0.14
CRY2FBXL3Q9R194Q9UKT7circadianregulationofgeneexpressioncircadianrhythmentrainmentofcircadianclockbyphotoperiodglucosehomeostasislipidstoragenegativeregulationofcircadianrhythmnegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofglucocorticoidsecretionnegativeregulationofphosphoproteinphosphataseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedproteinimportintonucleusregulationofcircadianrhythmregulationofsodium-dependentphosphatetransportresponsetoactivityresponsetoinsulinresponsetolightstimulusG2/MtransitionofmitoticcellcycleproteindestabilizationproteinubiquitinationregulationofcellcyclerhythmicprocessSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocess
Mothers against decapentaplegic homolog 2
362
Zinc finger FYVE domain-containing protein 9
783
8.6
74
0.16
SMAD2ZFYV9Q15796O95405activinreceptorsignalingpathwayadrenalglanddevelopmentanatomicalstructuremorphogenesisanterior/posteriorpatternspecificationBMPsignalingpathwaycelldifferentiationcellfatecommitmentcommon-partnerSMADproteinphosphorylationembryoniccranialskeletonmorphogenesisembryonicforegutmorphogenesisendodermformationgastrulationinuteroembryonicdevelopmentinsulinsecretionintracellularsignaltransductionlungdevelopmentmesodermformationnegativeregulationofcellpopulationproliferationnegativeregulationoftranscriptionDNA-templatednodalsignalingpathwayorgangrowthpancreasdevelopmentparaxialmesodermmorphogenesispericardiumdevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofgeneexpressionpositiveregulationofnodalsignalingpathwayinvolvedindeterminationoflateralmesodermleft/rightasymmetrypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpost-embryonicdevelopmentprimarymiRNAprocessingregulationofbindingregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoglucosesecondarypalatedevelopmentsignaltransductioninvolvedinregulationofgeneexpressionSMADproteincomplexassemblySMADproteinsignaltransductiontranscriptionDNA-templatedtransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentwoundhealingzygoticspecificationofdorsal/ventralaxisendocytosisendosomaltransport
BTB/POZ domain-containing protein KCTD12
294
BTB/POZ domain-containing protein KCTD12
294
7.7
88
0.15
KCD12KCD12Q96CX2Q96CX2proteinhomooligomerization
Tumor necrosis factor receptor superfamily member 9
77
Tumor necrosis factor receptor superfamily member 9
44
7.7
87
0.15
TNR9TNR9P20334P20334apoptoticprocessnegativeregulationofcellpopulationproliferationregulationofcellpopulationproliferationregulationofimmatureTcellproliferationinthymus
WD repeat-containing protein 48
200
WD repeat-containing protein 48
200
8.8
65
0.18
WDR48WDR48Q8TAF3Q8TAF3cellularresponsetoDNAdamagestimulusdouble-strandbreakrepairviahomologousrecombinationembryonicorgandevelopmenthomeostasisofnumberofcellsmulticellularorganismgrowthpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofepithelialcellproliferationproteindeubiquitinationregulationofproteinmonoubiquitinationseminiferoustubuledevelopmentsinglefertilizationskeletalsystemmorphogenesisskindevelopmentspermatogenesis
Growth/differentiation factor 8
340
Growth/differentiation factor 8
341
7.7
74
0.18
GDF8GDF8O08689O08689cellularresponsetodexamethasonestimulusmusclecellcellularhomeostasismyoblastmigrationinvolvedinskeletalmuscleregenerationnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofkinaseactivitynegativeregulationofmusclehypertrophynegativeregulationofmyoblastdifferentiationnegativeregulationofmyoblastproliferationnegativeregulationofproteinkinaseBsignalingnegativeregulationofsatellitecelldifferentiationnegativeregulationofskeletalmusclesatellitecellproliferationnegativeregulationofskeletalmuscletissuegrowthovulationcycleprocesspositiveregulationoflamellipodiumassemblypositiveregulationofmacrophagechemotaxispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionDNA-templatedresponsetoelectricalstimulusresponsetoestrogenresponsetoethanolresponsetogravityresponsetoheatresponsetomuscleactivityresponsetotestosteroneskeletalmuscleatrophySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Protein numb homolog
160
Protein numb homolog
160
7.6
95
0.14
NUMBNUMBP49757P49757adherensjunctionorganizationaxonogenesislateralventricledevelopmentnegativeregulationofproteinlocalizationtoplasmamembraneneuroblastdivisioninsubventricularzonepositiveregulationofcellmigrationpositiveregulationofneurogenesisregulationofpostsynapticneurotransmitterreceptorinternalization
Neutrophil elastase
71
Antileukoproteinase
122
7.6
86
0.15
ELNESLPIP08246P03973acuteinflammatoryresponsetoantigenicstimulusbiosyntheticprocessofantibacterialpeptidesactiveagainstGram-negativebacteriacellularcalciumionhomeostasisdefenseresponsetobacteriumextracellularmatrixdisassemblyleukocytemigrationinvolvedininflammatoryresponsenegativeregulationofchemokineproductionnegativeregulationofchemotaxisnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-8productionnegativeregulationoftranscriptionbyRNApolymeraseIIneutrophil-mediatedkillingoffungusneutrophil-mediatedkillingofgram-negativebacteriumphagocytosispositiveregulationofimmuneresponsepositiveregulationofinterleukin-8productionpositiveregulationofleukocytetetheringorrollingpositiveregulationofMAPkinaseactivitypositiveregulationofsmoothmusclecellproliferationproteincatabolicprocessproteolysispyroptosisresponsetolipopolysaccharideresponsetoUVresponsetoyeastantibacterialhumoralresponseimmuneresponseinnateimmuneresponsemodulationofprocessofanotherorganismnegativeregulationofproteinbindingnegativeregulationofviralgenomereplication
C-C motif chemokine 1
57
C-C motif chemokine 1
57
7.6
46
0.29
CCL1CCL1P22362P22362antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiseosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-17productionpositiveregulationofmonocytechemotaxissignaltransductionviralprocess
Peroxiredoxin-5, mitochondrial
204
Peroxiredoxin-5, mitochondrial
204
7.6
65
0.2
PRDX5PRDX5P30044P30044cellredoxhomeostasiscellularresponsetooxidativestresscellularresponsetoreactiveoxygenspecieshydrogenperoxidecatabolicprocessinflammatoryresponseNADPHoxidationnegativeregulationofapoptoticprocessnegativeregulationofoxidoreductaseactivitynegativeregulationoftranscriptionbyRNApolymeraseIIIpositiveregulationofcollagenbiosyntheticprocessreactivenitrogenspeciesmetabolicprocessregulationofapoptosisinvolvedintissuehomeostasisresponsetooxidativestress
BTB/POZ domain-containing protein KCTD1
221
BTB/POZ domain-containing protein KCTD1
221
7.6
102
0.13
KCTD1KCTD1Q719H9Q719H9negativeregulationoftranscriptionDNA-templatedproteinhomooligomerization
Butyrophilin subfamily 3 member A1
387
Butyrophilin subfamily 3 member A1
387
7.6
72
0.18
BT3A1BT3A1O00481O00481activatedTcellproliferationadaptiveimmuneresponsepositiveregulationofcytokineproductionpositiveregulationofinterferon-gammaproductionregulationofcytokineproductionTcellreceptorsignalingpathway
4-trimethylaminobutyraldehyde dehydrogenase
74
4-trimethylaminobutyraldehyde dehydrogenase
74
8.3
83
0.14
AL9A1AL9A1P49189P49189carnitinebiosyntheticprocesscellularaldehydemetabolicprocesshormonemetabolicprocessneurotransmitterbiosyntheticprocessproteinhomotetramerization
Complement C5
702
Complement C5
702
8.4
81
0.15
CO5CO5P06684P06684complementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisinuteroembryonicdevelopmentinflammatoryresponsenegativeregulationofmacrophagechemotaxispositiveregulationofangiogenesispositiveregulationofchemokineproductionpositiveregulationofimmuneresponsepositiveregulationofvascularendothelialgrowthfactorproduction
Toll-like receptor 10
706
Toll-like receptor 10
706
8.6
62
0.19
TLR10TLR10Q9BXR5Q9BXR5immuneresponseinflammatoryresponseinnateimmuneresponseMyD88-dependenttoll-likereceptorsignalingpathwaypositiveregulationofinflammatoryresponseregulationofcytokineproductiontoll-likereceptor10signalingpathwaytoll-likereceptorsignalingpathway
Ras and EF-hand domain-containing protein
20
Ras and EF-hand domain-containing protein
20
7.7
78
0.17
RASEFRASEFQ8IZ41Q8IZ41
Complement C5
731
Complement C5
731
8.6
85
0.14
CO5CO5P01031P01031cellsurfacereceptorsignalingpathwaychemotaxiscomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisGprotein-coupledreceptorsignalingpathwayinuteroembryonicdevelopmentinflammatoryresponsenegativeregulationofmacrophagechemotaxispositiveregulationofangiogenesispositiveregulationofchemokineproductionpositiveregulationofimmuneresponsepositiveregulationofvascularendothelialgrowthfactorproduction
Peroxisomal multifunctional enzyme type 2
230
Peroxisomal multifunctional enzyme type 2
277
8.6
58
0.2
DHB4DHB4P51659P51659androgenmetabolicprocessestrogenmetabolicprocessfattyacidbeta-oxidationmedium-chainfatty-acyl-CoAmetabolicprocessosteoblastdifferentiationSertolicelldevelopmentverylong-chainfattyacidmetabolicprocessverylong-chainfatty-acyl-CoAmetabolicprocess
Thioredoxin-interacting protein
247
Thioredoxin
73
8.8
88
0.13
TXNIPTHIOQ9H3M7P10599cellcyclecellularresponsetotumorcellkeratinocytedifferentiationnegativeregulationofcelldivisionnegativeregulationoftranscriptionbyRNApolymeraseIIplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofapoptoticprocessproteinimportintonucleusproteintransportregulationofcellpopulationproliferationresponsetocalciumionresponsetoestradiolresponsetoglucoseresponsetohydrogenperoxideresponsetomechanicalstimulusresponsetoprogesteroneresponsetoxenobioticstimulusactivationofproteinkinaseBactivitycellredoxhomeostasisnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleuspositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiation
Gamma-crystallin S
27
Gamma-crystallin S
25
8.8
65
0.18
CRYGSCRYGSP22914P22914lensdevelopmentincamera-typeeyemorphogenesisofanepitheliumvisualperception
Mucin-2
1092
Mucin-2
1088
7.7
83
0.16
MUC2MUC2Q02817Q02817maintenanceofgastrointestinalepithelium
ATP-dependent RNA helicase DHX8
637
ATP-dependent RNA helicase DHX8
651
7.3
86
0.16
DHX8DHX8Q14562Q14562mRNAsplicingviaspliceosomeRNAprocessingRNAsplicingspliceosomalcomplexdisassembly
Hepatocyte growth factor activator
448
Kunitz-type protease inhibitor 1
259
7.9
96
0.13
HGFASPIT1Q04756O43278bloodcoagulationproteolysiszymogenactivationbranchinginvolvedinlabyrinthinelayermorphogenesiscellularresponsetoBMPstimulusepidermisdevelopmentepitheliumdevelopmentextracellularmatrixorganizationnegativeregulationofneuralprecursorcellproliferationneuraltubeclosureplacentabloodvesseldevelopmentpositiveregulationofglialcelldifferentiation
E3 ubiquitin-protein ligase UHRF1
321
E3 ubiquitin-protein ligase UHRF1
321
7.3
62
0.22
UHRF1UHRF1Q96T88Q96T88cellcyclechromatinorganizationDNArepairhistonemonoubiquitinationhistoneubiquitinationmaintenanceofDNAmethylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAtopoisomerase(ATP-hydrolyzing)activitypositiveregulationofproteinmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIproteinautoubiquitinationproteinubiquitinationregulationofepithelialcellproliferationubiquitin-dependentproteincatabolicprocess
Enhancer of mRNA-decapping protein 3
311
Enhancer of mRNA-decapping protein 3
311
7.6
86
0.15
EDC3EDC3Q96F86Q96F86deadenylation-independentdecappingofnuclear-transcribedmRNAP-bodyassembly
F-box only protein 11
872
F-box only protein 11
888
7.2
60
0.23
FBX11FBX11Q86XK2Q86XK2proteinmodificationprocessproteinubiquitinationregulationofapoptoticprocesssensoryperceptionofsoundubiquitin-dependentproteincatabolicprocess
Neurotrophin-4
201
Neurotrophin-4
201
7.6
100
0.13
NTF4NTF4P34130P34130adultlocomotorybehaviorepidermisdevelopmentganglionmothercellfatedeterminationinnervationlong-termmemorymechanoreceptordifferentiationmemorymodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwayneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofpeptidyl-serinephosphorylationregulationofneurondifferentiationsensoryorganboundaryspecificationtastebuddevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathway
Kinesin-like protein KIF2C
310
Kinesin-like protein KIF2C
245
7.6
77
0.17
KIF2CKIF2CQ99661Q99661attachmentofmitoticspindlemicrotubulestokinetochorecelldivisionestablishmentormaintenanceofmicrotubulecytoskeletonpolaritymetaphaseplatecongressionmicrotubuledepolymerizationmicrotubule-basedmovementmitoticmetaphaseplatecongressionregulationofchromosomesegregation
E3 ubiquitin-protein ligase UHRF1
344
E3 ubiquitin-protein ligase UHRF1
344
8.6
66
0.18
UHRF1UHRF1Q96T88Q96T88cellcyclechromatinorganizationDNArepairhistonemonoubiquitinationhistoneubiquitinationmaintenanceofDNAmethylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAtopoisomerase(ATP-hydrolyzing)activitypositiveregulationofproteinmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIproteinautoubiquitinationproteinubiquitinationregulationofepithelialcellproliferationubiquitin-dependentproteincatabolicprocess
Prothrombin
407
Pancreatic trypsin inhibitor
49
8.8
97
0.12
THRBBPT1P00734P00974acute-phaseresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidebloodcoagulationbloodcoagulationcommonpathwaycellsurfacereceptorsignalingpathwaycytolysisbyhostofsymbiontcellsfibrinolysisnegativeregulationofastrocytedifferentiationnegativeregulationofbloodcoagulationnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationoffibrinolysisnegativeregulationofplateletactivationnegativeregulationofproteolysisneutrophil-mediatedkillingofgram-negativebacteriumplateletactivationpositiveregulationofbloodcoagulationpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationoflipidkinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinphosphorylationpositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofreleaseofsequesteredcalciumionintocytosolproteolysisregulationofbloodcoagulationregulationofcellshaperegulationofcytosoliccalciumionconcentrationresponsetowoundingzymogenactivationnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Vasopressin-neurophysin 2-copeptin
110
Vasopressin-neurophysin 2-copeptin
110
7.6
98
0.13
NEU2NEU2P01180P01180vasoconstriction
Thioredoxin
32
Thioredoxin
62
7.2
71
0.2
THIOTHIOP10599P10599activationofproteinkinaseBactivitycellredoxhomeostasisnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiation
Fibrinogen gamma-B chain
43
Fibrinogen gamma-B chain
32
8.2
78
0.16
FIBGFIBGP12799P12799bloodcoagulationfibrinclotformationcell-matrixadhesionplateletaggregationproteinpolymerization
4-aminobutyrate aminotransferase, mitochondrial
166
4-aminobutyrate aminotransferase, mitochondrial
166
7.2
102
0.14
GABTGABTP80147P80147behavioralresponsetococainegamma-aminobutyricacidcatabolicprocessneurotransmittercatabolicprocess
Dual specificity protein phosphatase 15
73
Dual specificity protein phosphatase 15
73
7.9
68
0.19
DUS15DUS15Q5QP65Q5QP65dephosphorylationproteindephosphorylationregulationofoligodendrocytedifferentiationsignaltransduction
Kunitz-type protease inhibitor 1
101
Suppressor of tumorigenicity 14 protein
657
8.6
91
0.13
H3BR01ST14H3BR01Q9Y5Y6epithelialcellmorphogenesisinvolvedinplacentalbranchingkeratinocytedifferentiationneuraltubeclosureproteincatabolicprocessproteolysis
Trypsin-3
121
Pancreatic trypsin inhibitor
49
8.3
95
0.13
TRY3BPT1P35030P00974antimicrobialhumoralresponsedigestionendothelialcellmigrationproteolysiszymogenactivationnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Growth/differentiation factor 5
466
Growth/differentiation factor 5
465
8.6
82
0.14
GDF5GDF5P43026P43026BMPsignalingpathwaycell-cellsignalingchondroblastdifferentiationchondrocytedifferentiationembryoniclimbmorphogenesisforelimbmorphogenesishindlimbmorphogenesismesenchymalcellapoptoticprocessnegativeregulationofchondrocytedifferentiationnegativeregulationofepithelialcellproliferationnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofneuronapoptoticprocessossificationinvolvedinboneremodelingpositiveregulationofBMPsignalingpathwaypositiveregulationofchondrocytedifferentiationpositiveregulationofneurondifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationregulationofmulticellularorganismgrowthregulationofSMADproteinsignaltransductionresponsetomechanicalstimulusSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Urokinase-type plasminogen activator
315
Urokinase-type plasminogen activator
219
8.6
90
0.13
UROKUROKP06869P06869angiogenesisfibrinolysisnegativeregulationoffibrinolysisnegativeregulationofplasminogenactivationneurondeathplasminogenactivationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofovulationpositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofsmoothmusclecellmigrationproteolysisregulationofcelladhesionregulationofcelladhesionmediatedbyintegrinregulationofcellpopulationproliferationregulationoffibrinolysisregulationofhepatocyteproliferationregulationofplasminogenactivationregulationofsignalingreceptoractivityregulationofsmoothmusclecellmigrationregulationofsmoothmusclecell-matrixadhesionresponsetohypoxiaskeletalmuscletissueregenerationsmoothmusclecellmigrationurokinaseplasminogenactivatorsignalingpathwaywoundhealing
Calcium/calmodulin-dependent protein kinase type II subunit alpha
428
Calcium/calmodulin-dependent protein kinase type II subunit alpha
428
7.1
103
0.14
KCC2AKCC2AQ9UQM7Q9UQM7angiotensin-activatedsignalingpathwaycalciumiontransportdendriticspinedevelopmentG1/Stransitionofmitoticcellcyclenegativeregulationofhydrolaseactivitypeptidyl-serinephosphorylationpeptidyl-threonineautophosphorylationpositiveregulationofcalciumiontransportpositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofNF-kappaBtranscriptionfactoractivityproteinautophosphorylationproteinphosphorylationregulationofendocannabinoidsignalingpathwayregulationofmitochondrialmembranepermeabilityinvolvedinapoptoticprocessregulationofneuronmigrationregulationofneuronalsynapticplasticityregulationofneurotransmittersecretionresponsetoischemia
4-aminobutyrate aminotransferase, mitochondrial
163
4-aminobutyrate aminotransferase, mitochondrial
163
6.6
88
0.17
GABTGABTP80147P80147behavioralresponsetococainegamma-aminobutyricacidcatabolicprocessneurotransmittercatabolicprocess
DNA (cytosine-5)-methyltransferase 3A
540
DNA (cytosine-5)-methyltransferase 3A
497
7.1
93
0.15
DNM3ADNM3AQ9Y6K1Q9Y6K1agingC-5methylationofcytosinecellularresponsetoaminoacidstimuluscellularresponsetobisphenolAcellularresponsetoethanolcellularresponsetohypoxiaDNAmethylationDNAmethylationinvolvedinembryodevelopmentDNAmethylationinvolvedingametegenerationDNAmethylationoncytosineDNAmethylation-dependentheterochromatinassemblyhepatocyteapoptoticprocessmitoticcellcyclenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneurondifferentiationpositiveregulationofcelldeathregulationofgeneexpressionbygenomicimprintingresponsetococaineresponsetoestradiolresponsetoionizingradiationresponsetoleadionresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulusspermatogenesis
C-C motif chemokine 16
60
C-C motif chemokine 16
37
7.1
64
0.22
CCL16CCL16O15467O15467cellcommunicationcell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
Dopamine beta-hydroxylase
154
Dopamine beta-hydroxylase
154
7.1
47
0.3
DOPODOPOP09172P09172behavioralresponsetoethanolbloodvesselremodelingchemicalsynaptictransmissiondopaminecatabolicprocessfearresponseglucosehomeostasishomoiothermyleukocytemediatedimmunityleukocytemigrationlocomotorybehaviormaternalbehaviormemorynorepinephrinebiosyntheticprocessoctopaminebiosyntheticprocesspositiveregulationofcold-inducedthermogenesispositiveregulationofvasoconstrictionregulationofextrinsicapoptoticsignalingpathwayregulationofvascularassociatedsmoothmusclecellproliferationregulationofvascularendothelialcellproliferationresponsetoamphetamineresponsetopainvasoconstrictionvisuallearning
T-cell surface glycoprotein YE1/48
145
T-cell surface glycoprotein YE1/48
145
8.6
53
0.22
KLRA1KLRA1P20937P20937celladhesion
Protection of telomeres protein 1
464
Adrenocortical dysplasia protein homolog
199
9.7
64
0.16
POTE1ACDQ9NUX5Q96AP0DNAduplexunwindingestablishmentofproteinlocalizationtotelomerenegativeregulationoftelomeraseactivitynegativeregulationoftelomeremaintenanceviatelomerasepositiveregulationofDNAhelicaseactivitypositiveregulationofDNAstrandelongationpositiveregulationofhelicaseactivitypositiveregulationoftelomeraseactivitypositiveregulationoftelomeremaintenancepositiveregulationoftelomeremaintenanceviatelomeraseregulationofDNAhelicaseactivityregulationofdouble-strandbreakrepairvianonhomologousendjoiningregulationoftelomeremaintenanceviatelomerasetelomereassemblytelomerecappingtelomeremaintenanceviatelomerasetelomericD-loopdisassemblyembryoniclimbmorphogenesisintracellularproteintransportpositiveregulationofsingle-strandedtelomericDNAbindingprotectionfromnon-homologousendjoiningattelomereproteinlocalizationtochromosometelomericregionsegmentationskeletalsystemdevelopmenttelomeremaintenanceurogenitalsystemdevelopment
Nitric oxide synthase, endothelial
382
Nitric oxide synthase, endothelial
382
7.1
74
0.19
NOS3NOS3P29474P29474angiogenesisaorticvalvemorphogenesisargininecatabolicprocessbloodvesseldiametermaintenancebloodvesselremodelingcalciumiontransportcellredoxhomeostasisendocardialcushionmorphogenesisendothelialcellmigrationestablishmentoflocalizationincellhomeostasisofnumberofcellswithinatissueinuteroembryonicdevelopmentlipopolysaccharide-mediatedsignalingpathwaylungdevelopmentmitochondrionorganizationnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodpressurenegativeregulationofcalciumiontransportnegativeregulationofcellpopulationproliferationnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrolaseactivitynegativeregulationofmusclehyperplasianegativeregulationofplateletactivationnegativeregulationofpotassiumiontransportnegativeregulationofsmoothmusclecellproliferationnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionovulationfromovarianfolliclepositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofgeneexpressionpositiveregulationofguanylatecyclaseactivitypositiveregulationofNotchsignalingpathwaypotassiumiontransportpulmonaryvalvemorphogenesisregulationofbloodpressureregulationofnervoussystemprocessregulationofsodiumiontransportregulationofsystemicarterialbloodpressurebyendothelinregulationoftheforceofheartcontractionbychemicalsignalremovalofsuperoxideradicalsresponsetofluidshearstressresponsetoheatresponsetohormoneresponsetolipopolysaccharidesmoothmusclehyperplasiavasodilationventricularseptummorphogenesis
Serine protease 1
132
Serine protease 1
132
6.6
73
0.21
TRY1TRY1P00760P00760digestionproteolysis
Adrenodoxin, mitochondrial
112
Adrenodoxin, mitochondrial
106
8.6
73
0.16
ADXADXP10109P10109cellularresponsetocAMPcellularresponsetoforskolincholesterolmetabolicprocesselectrontransportchainhormonebiosyntheticprocessP450-containingelectrontransportchainpositiveregulationofoxidoreductaseactivitysteroidbiosyntheticprocess
Trypsin
156
Trypsin
117
9.7
78
0.13
TRYPTRYPP00761P00761digestionproteolysis
Bleomycin hydrolase
40
Bleomycin hydrolase
223
8.6
78
0.15
BLMHBLMHQ13867Q13867homocysteinecatabolicprocessproteinpolyubiquitinationproteolysisresponsetotoxicsubstanceresponsetoxenobioticstimulus
Ubiquitin carboxyl-terminal hydrolase 25
551
Ubiquitin carboxyl-terminal hydrolase 25
551
8.6
65
0.18
UBP25UBP25Q9UHP3Q9UHP3negativeregulationofERADpathwayproteindeubiquitinationproteinK48-linkeddeubiquitinationproteinK63-linkeddeubiquitinationproteinmodificationprocessproteolysisubiquitin-dependentproteincatabolicprocess
Histone deacetylase 6
1120
Histone deacetylase 6
1186
9.7
58
0.18
HDAC6HDAC6Q9UBN7Q9UBN7aggresomeassemblyautophagyaxonaltransportofmitochondrioncellularresponsetohydrogenperoxidecellularresponsetomisfoldedproteincellularresponsetotopologicallyincorrectproteinciliumassemblyciliumdisassemblycollateralsproutingdendriticspinemorphogenesishistonedeacetylationHsp90deacetylationintracellularproteintransportlysosomelocalizationnegativeregulationofhydrogenperoxidemetabolicprocessnegativeregulationofmicrotubuledepolymerizationnegativeregulationofoxidoreductaseactivitynegativeregulationofprotein-containingcomplexassemblynegativeregulationofprotein-containingcomplexdisassemblynegativeregulationofproteolysisnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedparkin-mediatedstimulationofmitophagyinresponsetomitochondrialdepolarizationpeptidyl-lysinedeacetylationpolyubiquitinatedmisfoldedproteintransportpositiveregulationofepithelialcellmigrationpositiveregulationofhydrogenperoxide-mediatedprogrammedcelldeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsignalingreceptoractivityproteindeacetylationproteindestabilizationproteinpolyubiquitinationproteinqualitycontrolformisfoldedorincompletelysynthesizedproteinsprotein-containingcomplexdisassemblyregulationofandrogenreceptorsignalingpathwayregulationofautophagyregulationofautophagyofmitochondrionregulationofestablishmentofproteinlocalizationregulationoffatcelldifferentiationregulationofgeneexpressionepigeneticregulationofmacroautophagyregulationofmicrotubule-basedmovementregulationofproteinstabilityresponsetogrowthfactorresponsetomisfoldedproteintubulindeacetylationubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathway
Immunoglobulin heavy constant alpha 1
180
Immunoglobulin heavy constant alpha 1
180
6.8
44
0.33
IGHA1IGHA1P01876P01876adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
Mineralocorticoid receptor
645
Mineralocorticoid receptor
639
7.1
65
0.22
MCRMCRP08235P08235intracellularsteroidhormonereceptorsignalingpathwaypositiveregulationofNIK/NF-kappaBsignalingregulationoftranscriptionbyRNApolymeraseIIsignaltransduction
Placenta growth factor
77
Placenta growth factor
87
8.4
65
0.18
PLGFPLGFP49763P49763animalorganregenerationcelldifferentiationcell-cellsignalingcellularresponsetohormonestimulusfemalepregnancyinductionofpositivechemotaxispositiveregulationofangiogenesispositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellproliferationpositiveregulationofmastcellchemotaxispositiveregulationofproteinphosphorylationresponsetohypoxiaresponsetoxenobioticstimulussignaltransductionsproutingangiogenesisvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathway
Placenta growth factor
52
Placenta growth factor
77
9.6
68
0.15
PLGFPLGFP49763P49763animalorganregenerationcelldifferentiationcell-cellsignalingcellularresponsetohormonestimulusfemalepregnancyinductionofpositivechemotaxispositiveregulationofangiogenesispositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellproliferationpositiveregulationofmastcellchemotaxispositiveregulationofproteinphosphorylationresponsetohypoxiaresponsetoxenobioticstimulussignaltransductionsproutingangiogenesisvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathway
Glucocorticoid receptor
463
Glucocorticoid receptor
457
7.1
66
0.21
GCRGCRP79269P79269cellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluschromatinorganizationpositiveregulationoftranscriptionbyRNApolymeraseII
Integrin alpha-X
655
Integrin alpha-X
655
8.6
72
0.16
ITAXITAXP20702P20702animalorganmorphogenesiscelladhesioncelladhesionmediatedbyintegrincell-celladhesioncell-matrixadhesiondefenseresponsetovirusheterotypiccell-celladhesionintegrin-mediatedsignalingpathwaypositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialtubemorphogenesispositiveregulationofgeneexpressionpositiveregulationofmyelination
Alcohol dehydrogenase 1A
101
Alcohol dehydrogenase 1A
287
9.6
66
0.16
ADH1AADH1AP07327P07327alcoholmetabolicprocessethanoloxidationretinoicacidmetabolicprocessretinolmetabolicprocess
Glutamine synthetase
42
Glutamine synthetase
163
7.1
82
0.17
GLNAGLNAP15104P15104ammoniaassimilationcycleangiogenesiscellpopulationproliferationcellularresponsetostarvationglutamatecatabolicprocessglutaminebiosyntheticprocesspositiveregulationofepithelialcellproliferationpositiveregulationofinsulinsecretionpositiveregulationofsynaptictransmissionglutamatergicproteinpalmitoylationregulationofendothelialcellmigrationregulationofproteinlocalizationtonucleolusregulationofsproutingangiogenesisresponsetoglucoseribosomebiogenesis
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
122
8.6
65
0.18
GNAI1B1H241P10824B1H241adenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaynegativeregulationofsynaptictransmissionpositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaybasementmembraneorganizationcellmigrationinvolvedingastrulationcell-celladhesioninvolvedingastrulationinuteroembryonicdevelopmentvasculaturedevelopmentvisuallearning
Toll-like receptor 2
750
Toll-like receptor 2
673
8.4
73
0.16
TLR2TLR2O60603O60603apoptoticprocesscellactivationcellularresponsetobacteriallipopeptidecellularresponsetodiacylbacteriallipopeptidecellularresponsetointerferon-gammacellularresponsetolipoteichoicacidcellularresponsetotriacylbacteriallipopeptidecentralnervoussystemmyelinformationdefenseresponsetoGram-positivebacteriumdefenseresponsetovirusdetectionofdiacylbacteriallipopeptidedetectionoftriacylbacteriallipopeptideI-kappaBphosphorylationimmuneresponseinflammatoryresponseinnateimmuneresponselearningleukotrienemetabolicprocessmicrogliadevelopmentmicroglialcellactivationMyD88-dependenttoll-likereceptorsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofphagocytosisnegativeregulationofsynapseassemblynitricoxidemetabolicprocesspositiveregulationofcellularresponsetomacrophagecolony-stimulatingfactorstimuluspositiveregulationofchemokineproductionpositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-18productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofmatrixmetallopeptidasesecretionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofoligodendrocytedifferentiationpositiveregulationoftoll-likereceptorsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationofWntsignalingpathwayresponsetofattyacidresponsetohypoxiaresponsetoinsulinresponsetoprogesteroneresponsetotoxicsubstancesignaltransductiontoll-likereceptor2signalingpathwaytoll-likereceptorsignalingpathwaytoll-likereceptorTLR6
Adrenodoxin, mitochondrial
110
Adrenodoxin, mitochondrial
110
6.5
93
0.17
ADXADXP00257P00257cellularresponsetocAMPcellularresponsetoforskolincholesterolmetabolicprocesselectrontransportchainhormonebiosyntheticprocessP450-containingelectrontransportchainpositiveregulationofoxidoreductaseactivityrespiratoryelectrontransportchainsteroidbiosyntheticprocess
DNA repair protein XRCC4
165
Non-homologous end joining factor IFFO1
515
8.6
37
0.31
XRCC4IFFO1Q13426Q0D2I5DNAligationinvolvedinDNArepairdouble-strandbreakrepairdouble-strandbreakrepairvianonhomologousendjoiningimmunoglobulinV(D)Jrecombinationpositiveregulationofligaseactivitypositiveregulationofphosphatidylserineexposureonapoptoticcellsurfaceproteinlocalizationtositeofdouble-strandbreakresponsetoX-rayDNAdouble-strandbreakattachmenttonuclearenvelope
Serine/threonine-protein kinase receptor R3
443
Serine/threonine-protein kinase receptor R3
389
7.1
63
0.22
ACVL1ACVL1P37023P37023angiogenesisarterydevelopmentbloodcirculationbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisbloodvesselmaturationbloodvesselremodelingBMPsignalingpathwaycellularresponsetoBMPstimuluscellularresponsetogrowthfactorstimuluscellularresponsetotransforminggrowthfactorbetastimulusdorsalaortamorphogenesisdorsal/ventralpatternformationendocardialcushionmorphogenesisendothelialtubemorphogenesisheartdevelopmentinuteroembryonicdevelopmentlymphangiogenesislymphaticendothelialcelldifferentiationnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcelladhesionnegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationofDNAbiosyntheticprocessnegativeregulationofendothelialcelldifferentiationnegativeregulationofendothelialcellmigrationnegativeregulationofendothelialcellproliferationnegativeregulationoffocaladhesionassemblynegativeregulationofgeneexpressionpositiveregulationofangiogenesispositiveregulationofBMPsignalingpathwaypositiveregulationofchondrocytedifferentiationpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedproteinphosphorylationregulationofbloodpressureregulationofbloodvesselendothelialcellmigrationregulationofDNAreplicationregulationofendothelialcellproliferationregulationoftranscriptionDNA-templatedresponsetohypoxiaretinavasculaturedevelopmentincamera-typeeyesignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwayvenousbloodvesseldevelopmentwoundhealingspreadingofepidermalcells
Integrin beta-2
36
Integrin beta-2
447
7.1
67
0.21
ITB2ITB2P05107P05107amyloid-betaclearanceapoptoticprocesscelladhesioncelladhesionmediatedbyintegrincellmigrationcell-celladhesioncell-celladhesionviaplasma-membraneadhesionmoleculescell-cellsignalingcell-matrixadhesioncellularresponsetolow-densitylipoproteinparticlestimulusendodermalcelldifferentiationheterotypiccell-celladhesioninflammatoryresponseintegrin-mediatedsignalingpathwayleukocytecell-celladhesionmicroglialcellactivationnegativeregulationofdopaminemetabolicprocessneutrophilchemotaxisneutrophilmigrationphagocytosisengulfmentpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofneurondeathpositiveregulationofneutrophildegranulationpositiveregulationofprostaglandin-Esynthaseactivitypositiveregulationofproteintargetingtomembranepositiveregulationofsuperoxideaniongenerationreceptorclusteringreceptorinternalizationreceptor-mediatedendocytosisregulationofcellshaperegulationofpeptidyl-tyrosinephosphorylation
Protein cereblon
397
Protein cereblon
397
8.6
63
0.18
CRBNCRBNQ8C7D2Q8C7D2locomotoryexplorationbehaviornegativeregulationofiontransmembranetransportnegativeregulationoflargeconductancecalcium-activatedpotassiumchannelactivitynegativeregulationofprotein-containingcomplexassemblypositiveregulationofprotein-containingcomplexassemblyproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitination
Ribonuclease inhibitor
409
Non-secretory ribonuclease
89
8.6
71
0.16
RINIRNAS2P13489P10153mRNAcatabolicprocessregulationofangiogenesischemotaxisdefenseresponsetovirusinnateimmuneresponseinmucosaRNAcatabolicprocessRNAphosphodiesterbondhydrolysis
3-hydroxybutyrate dehydrogenase type 2
172
3-hydroxybutyrate dehydrogenase type 2
145
9.6
95
0.11
BDH2BDH2Q9BUT1Q9BUT1epithelialcelldifferentiationfattyacidbeta-oxidationhememetabolicprocessironionhomeostasissiderophorebiosyntheticprocess
Pancreatic secretory granule membrane major glycoprotein GP2
146
Pancreatic secretory granule membrane major glycoprotein GP2
85
8.6
71
0.16
GP2GP2P55259P55259antigentranscytosisbyMcellsinmucosal-associatedlymphoidtissueinnateimmuneresponseneutrophilmigration
Mothers against decapentaplegic homolog 7
262
Mothers against decapentaplegic homolog 7
278
9.6
84
0.12
SMAD7SMAD7O35253O35253adherensjunctionassemblyanatomicalstructuremorphogenesisarterymorphogenesisBMPsignalingpathwaycelldifferentiationcellularresponsetoleukemiainhibitoryfactorcellularresponsetotransforminggrowthfactorbetastimulusintracellularsignaltransductionnegativeregulationofBMPsignalingpathwaynegativeregulationofchondrocyteproliferationnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofossificationnegativeregulationofpathway-restrictedSMADproteinphosphorylationnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofpeptidyl-threoninephosphorylationnegativeregulationofproteinubiquitinationnegativeregulationofTcellcytokineproductionnegativeregulationofT-helper17celldifferentiationnegativeregulationofT-helper17typeimmuneresponsenegativeregulationoftranscriptionbycompetitivepromoterbindingnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofubiquitin-proteintransferaseactivitypathway-restrictedSMADproteinphosphorylationpositiveregulationofcell-celladhesionpositiveregulationofchondrocytehypertrophypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinubiquitinationproteinstabilizationprotein-containingcomplexlocalizationregulationofactivinreceptorsignalingpathwayregulationofcardiacmusclecontractionregulationofepithelialtomesenchymaltransitionregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationofventricularcardiacmusclecellmembranedepolarizationresponsetolaminarfluidshearstressSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentventricularcardiacmuscletissuemorphogenesisventricularseptummorphogenesis
DNA repair protein RAD50
684
DNA repair protein RAD50
680
9.7
61
0.17
RAD50RAD50Q92878Q92878cellularresponsetoDNAdamagestimuluschromosomeorganizationinvolvedinmeioticcellcycleDNAdouble-strandbreakprocessingDNAduplexunwindingDNArecombinationDNArepairDNAstrandresectioninvolvedinreplicationforkprocessingdouble-strandbreakrepairhomologousrecombinationmitoticG2/Mtransitioncheckpointnegativeregulationoftelomerecappingnucleicacidphosphodiesterbondhydrolysispositiveregulationofkinaseactivitypositiveregulationofproteinautophosphorylationpositiveregulationoftelomeremaintenancereciprocalmeioticrecombinationregulationofmitoticrecombinationtelomeremaintenancetelomeremaintenanceviarecombinationtelomeremaintenanceviatelomerase"telomeric3overhangformation"
Tumor necrosis factor receptor superfamily member 9
64
Tumor necrosis factor receptor superfamily member 9
44
7.1
75
0.19
TNR9TNR9P20334P20334apoptoticprocessnegativeregulationofcellpopulationproliferationregulationofcellpopulationproliferationregulationofimmatureTcellproliferationinthymus
Androgen receptor
578
Androgen receptor
584
8.2
65
0.19
ANDRANDRP15207P15207activationofprostateinductionbyandrogenreceptorsignalingpathwayandrogenreceptorsignalingpathwayanimalorganformationcellularresponsetoestrogenstimuluscellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetosteroidhormonestimuluscellularresponsetotestosteronestimuluscopulationepithelialcelldifferentiationinvolvedinprostateglanddevelopmentepithelialcellmorphogenesisfertilizationinuteroembryonicdevelopmentintracellularestrogenreceptorsignalingpathwayintracellularreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaylateralsproutinginvolvedinmammaryglandductmorphogenesisLeydigcelldifferentiationmalecourtshipbehaviormalegenitaliamorphogenesismalegonaddevelopmentmalesexdifferentiationmalesomaticsexdeterminationmammaryglandalveolusdevelopmentmorphogenesisofanepithelialfoldmulticellularorganismgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofepithelialcellproliferationnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofintegrinbiosyntheticprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellproliferationinvolvedinprostateglanddevelopmentpositiveregulationofgeneexpressionpositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofintegrinbiosyntheticprocesspositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpenileerectionpositiveregulationofphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIpositiveregulationoftranscriptionDNA-templatedprostateglandepitheliummorphogenesisprostateglandgrowthregulationofdevelopmentalgrowthregulationofgeneexpressionregulationofprostaticbudformationregulationofproteinlocalizationtoplasmamembraneregulationofsystemicarterialbloodpressureregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedreproductivebehaviorreproductivestructuredevelopmentreproductivesystemdevelopmentresponsetoestradiolresponsetoinsulinresponsetotestosteroneseminiferoustubuledevelopmentsinglefertilizationskeletalmusclehypertrophyspermatogenesistertiarybranchinginvolvedinmammaryglandductmorphogenesis
Alanine--glyoxylate aminotransferase
293
Alanine--glyoxylate aminotransferase
293
9.7
81
0.13
AGT1AGT1Q8R128Q8R128glycinebiosyntheticprocessbytransaminationofglyoxylateglyoxylatecatabolicprocessglyoxylatemetabolicprocessL-alaninecatabolicprocessL-cysteinecatabolicprocessL-serinemetabolicprocessNotchsignalingpathwayoxalicacidsecretionpyruvatebiosyntheticprocessresponsetocAMPresponsetoglucocorticoid
Serine/threonine-protein kinase RIO2
268
Serine/threonine-protein kinase RIO2
268
7.0
68
0.21
RIOK2RIOK2Q9BVS4Q9BVS4cellcyclematurationofSSU-rRNApositiveregulationofribosomalsmallsubunitexportfromnucleuspositiveregulationofrRNAprocessingproteinautophosphorylationregulationofmitoticmetaphase/anaphasetransitionribosomalsmallsubunitbiogenesis
Spindle and kinetochore-associated protein 1
74
Spindle and kinetochore-associated protein 2
79
9.7
64
0.16
SKA1SKA2Q96BD8Q8WVK7celldivisionchromosomesegregationmitoticcellcycleregulationofmicrotubulepolymerizationordepolymerization
Growth/differentiation factor 15
240
Growth/differentiation factor 15
273
8.6
87
0.13
GDF15GDF15Q99988Q99988BMPsignalingpathwaycell-cellsignalingglialcell-derivedneurotrophicfactorreceptorsignalingpathwaynegativeregulationofgrowthhormonereceptorsignalingpathwaynegativeregulationofmulticellularorganismgrowthpositiveregulationofMAPKcascadepositiveregulationofmyoblastfusionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinkinaseBsignalingreductionoffoodintakeinresponsetodietaryexcesssignaltransductionSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Bone morphogenetic protein 6
477
Bone morphogenetic protein 6
478
7.1
85
0.17
BMP6BMP6P22004P22004BMPsignalingpathwaycartilagedevelopmentcellularironionhomeostasiscellularresponsetoBMPstimuluscellularresponsetoironioncellularresponsetomechanicalstimulusendochondralossificationeyedevelopmentimmuneresponseinflammatoryresponsekidneydevelopmentmalegenitaliadevelopmentmulticellularorganismalironionhomeostasisnegativeregulationofadherensjunctionorganizationnegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationoftranscriptionbyRNApolymeraseIIneurondifferentiationosteoblastdifferentiationpositiveregulationofaldosteronebiosyntheticprocesspositiveregulationofaldosteronesecretionpositiveregulationofbonemineralizationpositiveregulationofcellpopulationproliferationpositiveregulationofchondrocytedifferentiationpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofgeneexpressionpositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofneurondifferentiationpositiveregulationofosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinsecretionpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularpermeabilityresponsetoactivityresponsetoglucocorticoidresponsetomagnesiumionresponsetoretinoicacidskeletalsystemdevelopmentSMADproteinsignaltransductiontypeBpancreaticcelldevelopment
Glutamate receptor ionotropic, delta-1
80
Glutamate receptor ionotropic, delta-1
351
9.7
78
0.13
GRID1GRID1Q61627Q61627modulationofchemicalsynaptictransmissionsocialbehaviorsynaptictransmissionglutamatergic
Nitric-oxide synthase (NADPH)
382
Nitric-oxide synthase (NADPH)
382
7.1
71
0.2
A0S0A6A0S0A6A0S0A6A0S0A6nitricoxidebiosyntheticprocess
Amyloid-beta precursor protein
105
Amyloid-beta precursor protein
105
7.1
60
0.24
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
BTB/POZ domain-containing protein KCTD16
250
BTB/POZ domain-containing protein KCTD16
250
6.6
85
0.18
KCD16KCD16Q68DU8Q68DU8proteinhomooligomerizationregulationofGprotein-coupledreceptorsignalingpathway
ATP-binding cassette sub-family G member 8
311
ATP-binding cassette sub-family G member 5
291
6.6
50
0.3
ABCG8ABCG5Q9H221Q9H222bileacidsignalingpathwaycholesteroleffluxcholesterolhomeostasisintestinalcholesterolabsorptionnegativeregulationofintestinalcholesterolabsorptionnegativeregulationofintestinalphytosterolabsorptionphospholipidtransportresponsetomuscleactivityresponsetonutrientresponsetoxenobioticstimulussteroltransporttransmembranetransporttriglyceridehomeostasisresponsetoionizingradiation
Group 10 secretory phospholipase A2
125
Group 10 secretory phospholipase A2
125
7.1
79
0.18
PA2GXPA2GXO15496O15496arachidonicacidmetabolicprocessarachidonicacidsecretionaxonguidancecellularresponsetoleukemiainhibitoryfactorcholesterolhomeostasisdefenseresponsetoviruserythrocytematurationfertilizationhairfolliclemorphogenesisintestinalstemcellhomeostasislow-densitylipoproteinparticleremodelinglysophospholipidtransportmacrophageactivationnegativeregulationofcholesteroleffluxnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofinflammatoryresponsephosphatidicacidmetabolicprocessphosphatidylcholinecatabolicprocessphosphatidylcholinemetabolicprocessphosphatidylethanolaminemetabolicprocessphosphatidylglycerolmetabolicprocessphosphatidylserinemetabolicprocessphospholipidmetabolicprocessplateletactivatingfactorcatabolicprocesspositiveregulationofacrosomereactionpositiveregulationofarachidonicacidsecretionpositiveregulationoflipidstoragepositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofprostaglandinsecretionpositiveregulationofproteinmetabolicprocessproductionofmolecularmediatorinvolvedininflammatoryresponseprostaglandinbiosyntheticprocessregulationofmacrophageactivation
Kunitz-type protease inhibitor 1
77
Suppressor of tumorigenicity 14 protein
657
8.3
103
0.12
H3BR01ST14H3BR01Q9Y5Y6epithelialcellmorphogenesisinvolvedinplacentalbranchingkeratinocytedifferentiationneuraltubeclosureproteincatabolicprocessproteolysis
Glutamate receptor ionotropic, delta-1
80
Glutamate receptor ionotropic, delta-1
80
8.6
81
0.14
GRID1GRID1Q61627Q61627modulationofchemicalsynaptictransmissionsocialbehaviorsynaptictransmissionglutamatergic
Poly [ADP-ribose] polymerase tankyrase-1
1245
Poly [ADP-ribose] polymerase tankyrase-1
1245
8.6
59
0.2
TNKS1TNKS1O95271O95271celldivisionmitoticspindleorganizationmRNAtransportnegativeregulationofmaintenanceofmitoticsisterchromatidcohesiontelomericnegativeregulationoftelomeremaintenanceviatelomerelengtheningnegativeregulationoftelomericDNAbindingpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationoftelomeraseactivitypositiveregulationoftelomerecappingpositiveregulationoftelomeremaintenanceviatelomerasepositiveregulationoftranscriptionbyRNApolymeraseIIproteinADP-ribosylationproteinauto-ADP-ribosylationproteinlocalizationtochromosometelomericregionproteinpoly-ADP-ribosylationproteinpolyubiquitinationproteintransportregulationoftelomeremaintenanceviatelomerasespindleassemblyWntsignalingpathway
Heat shock protein beta-1
137
Heat shock protein beta-1
137
6.6
64
0.24
HSPB1HSPB1P04792P04792anterogradeaxonalproteintransportcellularresponsetovascularendothelialgrowthfactorstimuluschaperone-mediatedproteinfoldingintracellularsignaltransductionnegativeregulationofapoptoticprocessnegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteinkinaseactivityplateletaggregationpositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofendothelialcellchemotaxispositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofinterleukin-1betaproductionpositiveregulationoftumornecrosisfactorproductionproteinrefoldingregulationofautophagyregulationofI-kappaBkinase/NF-kappaBsignalingregulationofproteinphosphorylationregulationoftranslationalinitiationresponsetoheatresponsetounfoldedproteinresponsetovirusretinahomeostasis
SPARC
95
SPARC
95
7.1
82
0.17
SPRCSPRCP09486P09486anatomicalstructuredevelopmentnegativeregulationofangiogenesisnegativeregulationofendothelialcellproliferationpositiveregulationofendothelialcellmigrationregulationofcellmorphogenesis
Regulator of G-protein signaling 3
314
Regulator of G-protein signaling 3
354
8.6
64
0.18
RGS3RGS3P49796P49796Gprotein-coupledreceptorsignalingpathwaynegativeregulationofsignaltransductionregulationofGprotein-coupledreceptorsignalingpathwaysignaltransduction
Bone morphogenetic protein 3
436
Bone morphogenetic protein 3
399
7.9
88
0.14
BMP3BMP3P12645P12645cartilagedevelopmentcell-cellsignalingosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationskeletalsystemdevelopmentSMADproteinsignaltransduction
Protein fem-1 homolog C
64
Protein fem-1 homolog C
64
6.5
68
0.23
FEM1CFEM1CQ96JP0Q96JP0proteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitinationubiquitin-dependentproteincatabolicprocessubiquitin-dependentproteincatabolicprocessviatheC-enddegronrulepathway
Mitotic spindle assembly checkpoint protein MAD1
568
Mitotic spindle assembly checkpoint protein MAD1
568
7.3
37
0.37
MD1L1MD1L1Q9Y6D9Q9Y6D9attachmentofmitoticspindlemicrotubulestokinetochorecelldivisioncytoplasmicsequesteringofproteindeactivationofmitoticspindleassemblycheckpointmitoticspindleassemblycheckpointsignalingnegativeregulationofTcellproliferationpositiveregulationofmitoticcellcyclespindleassemblycheckpointregulationofmetaphaseplatecongressionthymusdevelopment
Proprotein convertase subtilisin/kexin type 9
378
Low-density lipoprotein receptor
329
8.4
81
0.15
PCSK9LDLRQ8NBP7Q59FQ1apoptoticprocesscellularresponsetoinsulinstimuluscellularresponsetostarvationcholesterolhomeostasischolesterolmetabolicprocesskidneydevelopmentlipoproteinmetabolicprocessliverdevelopmentlow-densitylipoproteinparticlereceptorcatabolicprocesslysosomaltransportnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationoflow-densitylipoproteinparticlereceptorbindingnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofreceptorinternalizationnegativeregulationofreceptorrecyclingnegativeregulationofreceptor-mediatedendocytosisinvolvedincholesteroltransportnegativeregulationofsodiumiontransmembranetransporteractivityneurogenesisneurondifferentiationphospholipidmetabolicprocesspositiveregulationoflow-densitylipoproteinparticlereceptorcatabolicprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofreceptorinternalizationproteinautoprocessingregulationofneuronapoptoticprocessregulationofsignalingreceptoractivitytriglyceridemetabolicprocessamyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessarterymorphogenesiscellularresponsetofattyacidcellularresponsetolow-densitylipoproteinparticlestimuluscholesterolimportcholesteroltransportendocytosishigh-densitylipoproteinparticleclearanceintestinalcholesterolabsorptionlipidmetabolicprocesslipoproteincatabolicprocesslong-termmemorylow-densitylipoproteinparticleclearancenegativeregulationofamyloidfibrilformationnegativeregulationofastrocyteactivationnegativeregulationofgeneexpressionnegativeregulationofmicroglialcellactivationnegativeregulationofproteinmetabolicprocessphagocytosisphospholipidtransportplasmalipoproteinparticleclearancepositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationoflysosomalproteincatabolicprocesspositiveregulationoftriglyceridebiosyntheticprocessreceptor-mediatedendocytosisreceptor-mediatedendocytosisinvolvedincholesteroltransportregulationofcholesterolmetabolicprocessregulationofphosphatidylcholinecatabolicprocessregulationofproteinmetabolicprocessresponsetocaloricrestriction
Dihydropyrimidinase-related protein 1
323
Dihydropyrimidinase-related protein 1
323
9.6
68
0.15
DPYL1DPYL1P97427P97427axonguidancemicrotubulecytoskeletonorganizationnegativeregulationofactinfilamentbindingnegativeregulationofneuronprojectiondevelopmentsemaphorin-plexinsignalingpathway
Secreted frizzled-related protein 3
147
Secreted frizzled-related protein 3
108
7.3
82
0.17
SFRP3SFRP3P97401P97401canonicalWntsignalingpathwaycochleamorphogenesisconvergentextensioninvolvedinorganogenesisepithelialcelldevelopmenthepatocytedifferentiationinnerearmorphogenesisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcartilagedevelopmentnegativeregulationofcelldevelopmentnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofhepatocytedifferentiationnegativeregulationofWntsignalingpathwayneuralcrestcelldifferentiationpositiveregulationofapoptoticprocesspositiveregulationoffatcelldifferentiationsomitedevelopment
Metabotropic glutamate receptor 1
601
Metabotropic glutamate receptor 1
601
9.6
49
0.21
GRM1GRM1Q13255Q13255cellularresponsetoelectricalstimuluschemicalsynaptictransmissionGprotein-coupledglutamatereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayL-glutamateimportacrossplasmamembranelocomotorybehaviorpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofMAPKcascaderegulationofsensoryperceptionofpainregulationofsynaptictransmissionglutamatergicsensoryperceptionofpain
Paternally-expressed gene 3 protein
114
Paternally-expressed gene 3 protein
71
9.6
67
0.16
PEG3PEG3Q9GZU2Q9GZU2apoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofgeneexpressionregulationoftranscriptionbyRNApolymeraseII
Proproteinase E
196
Proproteinase E
196
9.6
98
0.11
CAC3CAC3P05805P05805digestionproteolysis
Mineralocorticoid receptor
639
Mineralocorticoid receptor
639
9.6
63
0.17
MCRMCRP08235P08235intracellularsteroidhormonereceptorsignalingpathwaypositiveregulationofNIK/NF-kappaBsignalingregulationoftranscriptionbyRNApolymeraseIIsignaltransduction
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
305
Succinate dehydrogenase assembly factor 2, mitochondrial
83
9.6
86
0.12
SDHASDHF2P31040Q9NX18mitochondrialelectrontransportsuccinatetoubiquinonenervoussystemdevelopmentprotonmotiveforce-drivenmitochondrialATPsynthesisrespiratoryelectrontransportchainsuccinatemetabolicprocesstricarboxylicacidcyclemitochondrialrespiratorychaincomplexIIassemblynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofepithelialtomesenchymaltransitionproteindephosphorylationprotein-FADlinkage
Ubiquitin carboxyl-terminal hydrolase MINDY-2
489
Ubiquitin carboxyl-terminal hydrolase MINDY-2
489
8.4
67
0.18
MINY2MINY2Q8NBR6Q8NBR6proteinK48-linkeddeubiquitination
Protein arginine N-methyltransferase 8
273
Protein arginine N-methyltransferase 8
295
6.5
81
0.19
ANM8ANM8Q9NR22Q9NR22histonemethylationpeptidyl-argininemethylationpeptidyl-argininemethylationtoasymmetrical-dimethylarginineproteinhomooligomerizationproteinmethylationregulationofproteinbinding
Gamma-interferon-inducible lysosomal thiol reductase
145
Gamma-interferon-inducible lysosomal thiol reductase
145
7.3
77
0.18
GILTGILTQ9ESY9Q9ESY9antigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIInegativeregulationoffibroblastproliferationproteinstabilization
Coagulation factor IX
291
Coagulation factor IX
125
9.7
75
0.14
FA9FA9P16293P16293bloodcoagulationproteolysiszymogenactivation
Adrenodoxin, mitochondrial
106
Adrenodoxin, mitochondrial
106
8.4
55
0.22
ADXADXP10109P10109cellularresponsetocAMPcellularresponsetoforskolincholesterolmetabolicprocesselectrontransportchainhormonebiosyntheticprocessP450-containingelectrontransportchainpositiveregulationofoxidoreductaseactivitysteroidbiosyntheticprocess
Sequestosome-1
131
Sequestosome-1
151
8.7
70
0.16
SQSTMSQSTMQ13501Q13501aggrephagyapoptoticprocessautophagyautophagyofmitochondrionbrownfatcellproliferationcelldifferentiationendosomaltransportendosomeorganizationenergyhomeostasisimmunesystemprocessintracellularsignaltransductionmacroautophagymitophagynegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofapoptoticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinimportintonucleusproteinlocalizationproteinlocalizationtoperinuclearregionofcytoplasmproteinphosphorylationregulationofI-kappaBkinase/NF-kappaBsignalingregulationofmitochondrionorganizationregulationofproteincomplexstabilityregulationofRasproteinsignaltransductionresponsetoischemiaresponsetomitochondrialdepolarisationselectiveautophagytemperaturehomeostasistranscriptionbyRNApolymeraseIIubiquitin-dependentproteincatabolicprocess
NACHT, LRR and PYD domains-containing protein 1 allele 2
1064
NACHT, LRR and PYD domains-containing protein 1 allele 2
1064
7.9
76
0.17
NL1A2NL1A2D9I2G3D9I2G3inflammatoryresponseinnateimmuneresponseprogrammedcelldeathproteolysisregulationofapoptoticprocess
Chymotrypsin-like elastase family member 1
72
Elafin
83
7.9
98
0.13
CELA1ELAFP00772P19957proteolysisantibacterialhumoralresponsecopulationinnateimmuneresponsepeptidecross-linking
Glucocorticoid receptor
476
Glucocorticoid receptor
463
9.7
68
0.15
GCRGCRP79269P79269cellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluschromatinorganizationpositiveregulationoftranscriptionbyRNApolymeraseII
Fatty acid-binding protein 5
67
Fatty acid-binding protein 5
47
7.9
54
0.23
FABP5FABP5Q01469Q01469epidermisdevelopmentfattyacidtransportglucosehomeostasisglucosemetabolicprocesslipidmetabolicprocesslipidtransportacrossblood-brainbarrierlong-chainfattyacidtransportnegativeregulationofglucosetransmembranetransportphosphatidylcholinebiosyntheticprocesspositiveregulationofcold-inducedthermogenesispositiveregulationofperoxisomeproliferatoractivatedreceptorsignalingpathwayregulationofprostaglandinbiosyntheticprocessregulationofretrogradetrans-synapticsignalingbyendocanabinoidregulationofsensoryperceptionofpain
Cytoglobin
83
Cytoglobin
83
7.3
86
0.16
CYGBCYGBQ8WWM9Q8WWM9fattyacidoxidationnegativeregulationofcollagenbiosyntheticprocessnegativeregulationoffibroblastmigrationnegativeregulationofhepaticstellatecellactivationoxygentransportresponsetohypoxiaresponsetooxidativestress
Complement C5
728
Complement C5
728
8.3
71
0.17
CO5CO5P06684P06684complementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisinuteroembryonicdevelopmentinflammatoryresponsenegativeregulationofmacrophagechemotaxispositiveregulationofangiogenesispositiveregulationofchemokineproductionpositiveregulationofimmuneresponsepositiveregulationofvascularendothelialgrowthfactorproduction
MORC family CW-type zinc finger protein 3
435
MORC family CW-type zinc finger protein 3
446
7.3
78
0.18
MORC3MORC3Q14149Q14149innateimmuneresponsemaintenanceofproteinlocationinnucleusnegativeregulationoffibroblastproliferationpeptidyl-serinephosphorylationpositiveregulationofcellularsenescencepost-embryonicdevelopmentproteinphosphorylationproteinstabilization
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
624
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
624
9.7
70
0.15
PLCG2PLCG2Q8CIH5Q8CIH5activationofstore-operatedcalciumchannelactivityantifungalinnateimmuneresponseBcelldifferentiationBcellreceptorsignalingpathwaycalcium-mediatedsignalingcellactivationcellularresponsetocalciumioncellularresponsetolectincellularresponsetolipidfollicularBcelldifferentiationinositoltrisphosphatebiosyntheticprocessintracellularsignaltransductionlipopolysaccharide-mediatedsignalingpathwaymacrophageactivationinvolvedinimmuneresponsenegativeregulationofprogrammedcelldeathphosphatidylinositolbiosyntheticprocessphospholipidcatabolicprocesspositiveregulationofcalcium-mediatedsignalingpositiveregulationofcellcycleG1/SphasetransitionpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofdendriticcellcytokineproductionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofepithelialcellmigrationpositiveregulationofgeneexpressionpositiveregulationofI-kappaBphosphorylationpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-23productionpositiveregulationofinterleukin-6productionpositiveregulationofmacrophagecytokineproductionpositiveregulationofMAPKcascadepositiveregulationofneuroinflammatoryresponsepositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNLRP3inflammasomecomplexassemblypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphagocytosisengulfmentpositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofreceptorinternalizationpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIinterferonproductionprogrammedcelldeathregulationofcalcineurin-NFATsignalingcascaderegulationofgeneexpressionregulationofI-kappaBkinase/NF-kappaBsignalingregulationoflipidmetabolicprocessreleaseofsequesteredcalciumionintocytosolresponsetoATPresponsetoaxoninjuryresponsetolipopolysaccharideresponsetomagnesiumionresponsetoyeaststimulatoryC-typelectinreceptorsignalingpathwayTcellreceptorsignalingpathwaytoll-likereceptorsignalingpathway
APOBEC3H
116
APOBEC3H
88
8.8
59
0.19
B7TQM6B7TQM6B7TQM6B7TQM6
Ragulator complex protein LAMTOR4
51
Ragulator complex protein LAMTOR4
51
9.6
98
0.11
LTOR4LTOR4Q0VGL1Q0VGL1cellularresponsetoaminoacidstimuluspositiveregulationofTORsignalingproteinlocalizationtolysosomeregulationofcatalyticactivityregulationofcellsizeTORC1signaling
Sequestosome-1
154
Sequestosome-1
151
8.6
70
0.17
SQSTMSQSTMQ13501Q13501aggrephagyapoptoticprocessautophagyautophagyofmitochondrionbrownfatcellproliferationcelldifferentiationendosomaltransportendosomeorganizationenergyhomeostasisimmunesystemprocessintracellularsignaltransductionmacroautophagymitophagynegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofapoptoticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinimportintonucleusproteinlocalizationproteinlocalizationtoperinuclearregionofcytoplasmproteinphosphorylationregulationofI-kappaBkinase/NF-kappaBsignalingregulationofmitochondrionorganizationregulationofproteincomplexstabilityregulationofRasproteinsignaltransductionresponsetoischemiaresponsetomitochondrialdepolarisationselectiveautophagytemperaturehomeostasistranscriptionbyRNApolymeraseIIubiquitin-dependentproteincatabolicprocess
Serine/threonine-protein kinase Nek7
253
Serine/threonine-protein kinase Nek7
253
9.6
65
0.16
NEK7NEK7Q8TDX7Q8TDX7cellularresponsetopotassiumionpeptidyl-serinephosphorylationpositiveregulationofNLRP3inflammasomecomplexassemblypositiveregulationoftelomeraseactivitypositiveregulationoftelomerecappingpositiveregulationoftelomeremaintenanceviatelomeraseproteinphosphorylationregulationofmitoticcellcyclespindleassembly
Transforming growth factor beta-3 proprotein
378
Transforming growth factor beta-3 proprotein
377
7.1
85
0.17
TGFB3TGFB3P10600P10600agingBMPsignalingpathwaycell-celljunctionorganizationdetectionofhypoxiadigestivetractdevelopmentembryonicneurocraniummorphogenesisfacemorphogenesisfemalepregnancyfrontalsuturemorphogenesisinuteroembryonicdevelopmentinnereardevelopmentlungalveolusdevelopmentmammaryglanddevelopmentnegativeregulationofcellpopulationproliferationnegativeregulationofmacrophagecytokineproductionnegativeregulationofneuronapoptoticprocessnegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofvascularassociatedsmoothmusclecellproliferationodontogenesisossificationinvolvedinboneremodelingpositiveregulationofapoptoticprocesspositiveregulationofbonemineralizationpositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationoffilopodiumassemblypositiveregulationofMAPKcascadepositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofSMADproteinsignaltransductionpositiveregulationofstressfiberassemblypositiveregulationoftightjunctiondisassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofcellpopulationproliferationresponsetoestrogenresponsetohypoxiaresponsetolaminarfluidshearstressresponsetoprogesteronesalivaryglandmorphogenesissecondarypalatedevelopmentSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwayuterinewallbreakdownwoundhealing
NKG2-D type II integral membrane protein
105
NKG2-D type II integral membrane protein
105
6.5
87
0.18
NKG2DNKG2DP26718P26718adaptiveimmuneresponsecelldifferentiationcellularresponsetolipopolysaccharidedefenseresponsetoGram-positivebacteriumnaturalkillercellactivationnaturalkillercellmediatedcytotoxicitynegativeregulationofGTPaseactivitynegativeregulationofnaturalkillercellchemotaxisnitricoxidebiosyntheticprocesspositiveregulationofinterferon-gammaproductionpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnitricoxidebiosyntheticprocesssignaltransductionstimulatoryC-typelectinreceptorsignalingpathwayTcellcostimulation
C-type lectin domain family 4 member A
222
C-type lectin domain family 4 member A
222
8.4
98
0.12
CLC4ACLC4AQ9UMR7Q9UMR7adaptiveimmuneresponseantifungalinnateimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassICD8-positivealpha-betaTcellactivationcelladhesioncellsurfacereceptorsignalingpathwayimmuneresponsenegativeregulationofcytokineproductionnegativeregulationoftumornecrosisfactorproductionplasmacytoiddendriticcellantigenprocessingandpresentation
Acetyl-coenzyme A thioesterase
270
Acetyl-coenzyme A thioesterase
40
8.4
88
0.14
ACO12ACO12Q8WYK0Q8WYK0acetyl-CoAmetabolicprocessacyl-CoAmetabolicprocessfattyacidmetabolicprocess
Gremlin-2
120
Gremlin-2
123
9.6
70
0.15
GREM2GREM2O88273O88273animalorganmorphogenesiscytokine-mediatedsignalingpathwaydeterminationofdorsalidentityembryonicbodymorphogenesisnegativeregulationofBMPsignalingpathwayregulationofcytokineactivitysequesteringofBMPfromreceptorviaBMPbinding
Resistin
108
Resistin
108
8.6
77
0.15
RETNRETNQ99P87Q99P87fatcelldifferentiationnegativeregulationoffeedingbehaviorpositiveregulationofcollagenmetabolicprocesspositiveregulationofprogesteronesecretionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsynaptictransmissionresponsetoinsulin
Chymotrypsin-like elastase family member 1
56
Elafin
109
8.4
88
0.14
CELA1ELAFP00772P19957proteolysisantibacterialhumoralresponsecopulationinnateimmuneresponsepeptidecross-linking
TNF receptor-associated factor 2
287
TNF receptor-associated factor 2
287
9.6
61
0.17
TRAF2TRAF2Q12933Q12933activationofNF-kappaB-inducingkinaseactivitycellularresponsetonitricoxideinterleukin-17-mediatedsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressmRNAstabilizationnegativeregulationofglialcellapoptoticprocessnegativeregulationofneurondeathpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofI-kappaBphosphorylationpositiveregulationofinterleukin-2productionpositiveregulationofJNKcascadepositiveregulationofJUNkinaseactivitypositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofTcellcytokineproductionpositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayprogrammednecroticcelldeathproteinautoubiquitinationproteincatabolicprocessproteinK63-linkedubiquitinationprotein-containingcomplexassemblyregulationofapoptoticprocessregulationofI-kappaBkinase/NF-kappaBsignalingregulationofimmunoglobulinproductionregulationofprotein-containingcomplexassemblyresponsetoendoplasmicreticulumstresssignaltransductionsignaltransductioninvolvedinregulationofgeneexpressiontumornecrosisfactor-mediatedsignalingpathway
Caspase-4
109
Caspase-4
336
8.3
58
0.21
CASP4CASP4P49662P49662apoptoticprocesscellularresponsetoamyloid-betadefenseresponsetoGram-positivebacteriuminflammatoryresponseinnateimmuneresponseintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstresspositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-18-mediatedsignalingpathwaypositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayproteinautoprocessingproteolysispyroptosisregulationofapoptoticprocessregulationofinflammatoryresponse
ATP synthase subunit s, mitochondrial
126
ATP synthase subunit s, mitochondrial
126
9.6
81
0.13
ATP5SATP5SP22027P22027ATPbiosyntheticprocessiontransport
Golgi reassembly-stacking protein 2
173
Golgin-45
392
8.3
70
0.17
GORS2GO45Q99JX3Q8R2X8celldifferentiationestablishmentofproteinlocalizationtoplasmamembraneGolgiorganizationorganelleassemblyorganelleorganizationresponsetoendoplasmicreticulumstressspermatogenesisGolgitoplasmamembraneproteintransport
Fibrinogen gamma chain
45
Fibrinogen gamma chain
34
8.5
72
0.16
FIBGFIBGP02679P02679bloodcoagulationfibrinclotformationcell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetointerleukin-6fibrinolysisnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofplateletaggregationplasminogenactivationplateletaggregationplateletmaturationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationproteinsecretionprotein-containingcomplexassemblyresponsetocalciumion
Ferritin
127
Ferritin
127
9.6
65
0.16
Q9CPX4Q9CPX4Q9CPX4Q9CPX4cellularironionhomeostasisironiontransport
Speckle targeted PIP5K1A-regulated poly(A) polymerase
351
Speckle targeted PIP5K1A-regulated poly(A) polymerase
351
6.5
65
0.24
STPAPSTPAPQ9H6E5Q9H6E5mRNApolyadenylationpre-mRNAcleavagerequiredforpolyadenylation"RNA3-endprocessing"snRNAprocessing"U6snRNA3-endprocessing"
Lysine-specific histone demethylase 2
227
Lysine-specific histone demethylase 2
227
9.6
70
0.15
KDM1BKDM1BQ8NB78Q8NB78DNAmethylationinvolvedingametegenerationhistoneH3-K4demethylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNAmethylationregulationofgeneexpressionbygenomicimprinting
Tumor necrosis factor receptor superfamily member 9
121
Tumor necrosis factor receptor superfamily member 9
133
8.6
75
0.15
TNR9TNR9Q07011Q07011apoptoticprocessnegativeregulationofcellpopulationproliferationregulationofcellpopulationproliferationregulationofimmatureTcellproliferationinthymus
3-hydroxyisobutyrate dehydrogenase, mitochondrial
251
3-hydroxyisobutyrate dehydrogenase, mitochondrial
251
6.5
96
0.16
3HIDH3HIDHP31937P31937valinecatabolicprocess
Growth/differentiation factor 11
345
Growth/differentiation factor 11
371
8.4
70
0.17
GDF11GDF11O95390O95390amacrinecelldifferentiationcamera-typeeyemorphogenesiscellpopulationproliferationmesodermdevelopmentmetanephrosdevelopmentnegativeregulationofamacrinecelldifferentiationnegativeregulationofcellpopulationproliferationnervoussystemdevelopmentpositiveregulationofpathway-restrictedSMADproteinphosphorylationroofofmouthdevelopmentskeletalsystemdevelopmentSMADproteinsignaltransductionspinalcordanterior/posteriorpatterningtypeBpancreaticcellmaturationuretericbuddevelopment
Periaxin
86
Periaxin
86
7.1
68
0.21
PRAXPRAXQ9BXM0Q9BXM0axonensheathmentperipheralnervoussystemmyelinmaintenanceregulationofRNAsplicing
Phospholipase A2, major isoenzyme
99
Phospholipase A2, major isoenzyme
99
9.6
60
0.17
PA21BPA21BP00592P00592cellularresponsetoinsulinstimulusfattyacidbiosyntheticprocessintracellularsignaltransductionleukotrienebiosyntheticprocesslipidcatabolicprocessneutrophilchemotaxisneutrophilmediatedimmunityphosphatidylcholinemetabolicprocessphosphatidylglycerolmetabolicprocesspositiveregulationofcalciumiontransportintocytosolpositiveregulationofcellpopulationproliferationpositiveregulationoffibroblastproliferationpositiveregulationofimmuneresponsepositiveregulationofinterleukin-8productionpositiveregulationofMAPkinaseactivitypositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpodocyteapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofglucoseimport
Poly [ADP-ribose] polymerase 1
24
Poly [ADP-ribose] polymerase 1
24
9.6
51
0.2
PARP1PARP1P09874P09874apoptoticprocessATPgenerationfrompoly-ADP-D-ribosecellularresponsetoamyloid-betacellularresponsetoDNAdamagestimuluscellularresponsetoinsulinstimuluscellularresponsetooxidativestresscellularresponsetoUVcellularresponsetozincionDNAADP-ribosylationDNArepairdouble-strandbreakrepairmacrophagedifferentiationmitochondrialDNAmetabolicprocessmitochondrialDNArepairmitochondrionorganizationnegativeregulationofATPbiosyntheticprocessnegativeregulationoftelomeremaintenanceviatelomerelengtheningnegativeregulationoftranscriptionbyRNApolymeraseIIpeptidyl-glutamicacidpoly-ADP-ribosylationpeptidyl-serineADP-ribosylationpositiveregulationofcardiacmusclehypertrophypositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofmitochondrialdepolarizationpositiveregulationofmyofibroblastdifferentiationpositiveregulationofneurondeathpositiveregulationofproteinlocalizationtonucleuspositiveregulationofsinglestrandbreakrepairpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingproteinADP-ribosylationproteinauto-ADP-ribosylationproteinautoprocessingproteinmodificationprocessproteinpoly-ADP-ribosylationregulationofcatalyticactivityregulationofDNAmethylationregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwayregulationofproteinlocalizationregulationofSMADproteincomplexassemblyresponsetoaldosteroneresponsetogammaradiationsignaltransductioninvolvedinregulationofgeneexpressiontelomeremaintenancetranscriptionbyRNApolymeraseIItransforminggrowthfactorbetareceptorsignalingpathway
Insulin
88
Insulin
31
8.5
50
0.23
A6XGL2A6XGL2A6XGL2A6XGL2glucosemetabolicprocess
Bone morphogenetic protein 3
437
Bone morphogenetic protein 3
436
7.5
88
0.15
BMP3BMP3P12645P12645cartilagedevelopmentcell-cellsignalingosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationskeletalsystemdevelopmentSMADproteinsignaltransduction
Interferon alpha/beta receptor 2
227
Interferon alpha/beta receptor 2
227
7.0
81
0.18
INAR2INAR2P48551P48551cellsurfacereceptorsignalingpathwaycellularresponsetoviruscytokine-mediatedsignalingpathwaydefenseresponsetovirusreceptorsignalingpathwayviaJAK-STATresponsetointerferon-alpharesponsetointerferon-betaresponsetovirustypeIinterferonsignalingpathway
Glutamine synthetase
42
Glutamine synthetase
163
6.9
82
0.18
GLNAGLNAQ8HZM5Q8HZM5angiogenesisglutaminebiosyntheticprocessproteinpalmitoylationregulationofendothelialcellmigrationregulationofsproutingangiogenesis
Nuclear receptor ROR-gamma
455
Nuclear receptor ROR-gamma
455
8.5
67
0.17
RORGRORGP51449P51449adiposetissuedevelopmentcellularresponsetosterolcircadianregulationofgeneexpressionlymphnodedevelopmentnegativeregulationofthymocyteapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseII"Peyerspatchdevelopment"positiveregulationofcircadianrhythmpositiveregulationoftranscriptionDNA-templatedregulationoffatcelldifferentiationregulationofglucosemetabolicprocessregulationofsteroidmetabolicprocessregulationoftranscriptionbyRNApolymeraseIIT-helper17celldifferentiationT-helpercelldifferentiationxenobioticmetabolicprocess
Neutrophil elastase
71
Antileukoproteinase
96
7.8
95
0.13
ELNESLPIP08246P03973acuteinflammatoryresponsetoantigenicstimulusbiosyntheticprocessofantibacterialpeptidesactiveagainstGram-negativebacteriacellularcalciumionhomeostasisdefenseresponsetobacteriumextracellularmatrixdisassemblyleukocytemigrationinvolvedininflammatoryresponsenegativeregulationofchemokineproductionnegativeregulationofchemotaxisnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-8productionnegativeregulationoftranscriptionbyRNApolymeraseIIneutrophil-mediatedkillingoffungusneutrophil-mediatedkillingofgram-negativebacteriumphagocytosispositiveregulationofimmuneresponsepositiveregulationofinterleukin-8productionpositiveregulationofleukocytetetheringorrollingpositiveregulationofMAPkinaseactivitypositiveregulationofsmoothmusclecellproliferationproteincatabolicprocessproteolysispyroptosisresponsetolipopolysaccharideresponsetoUVresponsetoyeastantibacterialhumoralresponseimmuneresponseinnateimmuneresponsemodulationofprocessofanotherorganismnegativeregulationofproteinbindingnegativeregulationofviralgenomereplication
Pulmonary surfactant-associated protein B
298
Pulmonary surfactant-associated protein B
298
7.5
71
0.19
PSPBPSPBP50405P50405respiratorygaseousexchangebyrespiratorysystemsphingolipidmetabolicprocess
Histone deacetylase 6
1145
Histone deacetylase 6
1120
7.5
87
0.15
HDAC6HDAC6Q9UBN7Q9UBN7aggresomeassemblyautophagyaxonaltransportofmitochondrioncellularresponsetohydrogenperoxidecellularresponsetomisfoldedproteincellularresponsetotopologicallyincorrectproteinciliumassemblyciliumdisassemblycollateralsproutingdendriticspinemorphogenesishistonedeacetylationHsp90deacetylationintracellularproteintransportlysosomelocalizationnegativeregulationofhydrogenperoxidemetabolicprocessnegativeregulationofmicrotubuledepolymerizationnegativeregulationofoxidoreductaseactivitynegativeregulationofprotein-containingcomplexassemblynegativeregulationofprotein-containingcomplexdisassemblynegativeregulationofproteolysisnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedparkin-mediatedstimulationofmitophagyinresponsetomitochondrialdepolarizationpeptidyl-lysinedeacetylationpolyubiquitinatedmisfoldedproteintransportpositiveregulationofepithelialcellmigrationpositiveregulationofhydrogenperoxide-mediatedprogrammedcelldeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsignalingreceptoractivityproteindeacetylationproteindestabilizationproteinpolyubiquitinationproteinqualitycontrolformisfoldedorincompletelysynthesizedproteinsprotein-containingcomplexdisassemblyregulationofandrogenreceptorsignalingpathwayregulationofautophagyregulationofautophagyofmitochondrionregulationofestablishmentofproteinlocalizationregulationoffatcelldifferentiationregulationofgeneexpressionepigeneticregulationofmacroautophagyregulationofmicrotubule-basedmovementregulationofproteinstabilityresponsetogrowthfactorresponsetomisfoldedproteintubulindeacetylationubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathway
Calpain-2 catalytic subunit
191
Calpain-2 catalytic subunit
191
7.5
76
0.18
CAN2CAN2Q07009Q07009behavioralresponsetopainblastocystdevelopmentcellularresponsetoaminoacidstimuluscellularresponsetointerferon-betacellularresponsetolipopolysaccharidefemalepregnancymyoblastfusionpositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofmyoblastfusionpositiveregulationofneurondeathpositiveregulationofphosphatidylcholinebiosyntheticprocessproteinautoprocessingproteincatabolicprocessproteolysisproteolysisinvolvedinproteincatabolicprocessregulationofcytoskeletonorganizationregulationofinterleukin-6productionresponsetohydrogenperoxideresponsetohypoxiaresponsetomechanicalstimulus
Kunitz-type protease inhibitor 1
283
Suppressor of tumorigenicity 14 protein
657
8.3
91
0.13
SPIT1ST14O43278Q9Y5Y6branchinginvolvedinlabyrinthinelayermorphogenesiscellularresponsetoBMPstimulusepidermisdevelopmentepitheliumdevelopmentextracellularmatrixorganizationnegativeregulationofneuralprecursorcellproliferationneuraltubeclosureplacentabloodvesseldevelopmentpositiveregulationofglialcelldifferentiationepithelialcellmorphogenesisinvolvedinplacentalbranchingkeratinocytedifferentiationproteincatabolicprocessproteolysis
Protein S100-A3
83
Protein S100-A3
23
7.3
80
0.17
S10A3S10A3P33764P33764
Guanidinoacetate N-methyltransferase
16
Guanidinoacetate N-methyltransferase
16
8.4
81
0.15
GAMTGAMTQ14353Q14353animalorganmorphogenesiscreatinebiosyntheticprocesscreatinemetabolicprocessmethylationmusclecontractionregulationofmulticellularorganismgrowthspermatogenesis
Antiviral innate immune response receptor RIG-I
136
Mitochondrial antiviral-signaling protein
13
8.0
71
0.18
DDX58MAVSO95786Q7Z434antiviralinnateimmuneresponsecellularresponsetoexogenousdsRNAcytoplasmicpatternrecognitionreceptorsignalingpathwayinresponsetovirusdefenseresponsetovirusdetectionofvirusgeneexpressioninnateimmuneresponsepositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofgeneexpressionpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofmyeloiddendriticcellcytokineproductionpositiveregulationofresponsetocytokinestimuluspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionregulationofcellmigrationregulationoftypeIIIinterferonproductionresponsetoexogenousdsRNAresponsetovirusRIG-Isignalingpathwayactivationofinnateimmuneresponsedefenseresponsetobacteriumnegativeregulationofviralgenomereplicationpositiveregulationofchemokine(C-Cmotif)ligand5productionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofIP-10productionpositiveregulationofproteinimportintonucleuspositiveregulationofproteinphosphorylationpositiveregulationoftypeIinterferon-mediatedsignalingpathwayregulationofperoxisomeorganizationsignaltransductiontypeIinterferonsignalingpathway
APOBEC3H
85
APOBEC3H
88
7.8
77
0.17
B7TQM6B7TQM6B7TQM6B7TQM6
Complement C5
702
Complement C5
728
8.0
76
0.16
CO5CO5P06684P06684complementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisinuteroembryonicdevelopmentinflammatoryresponsenegativeregulationofmacrophagechemotaxispositiveregulationofangiogenesispositiveregulationofchemokineproductionpositiveregulationofimmuneresponsepositiveregulationofvascularendothelialgrowthfactorproduction
Immunoglobulin heavy constant alpha 1
182
Immunoglobulin heavy constant alpha 1
180
7.0
53
0.27
IGHA1IGHA1P01876P01876adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
Suppressor of tumorigenicity 14 protein
657
Pancreatic trypsin inhibitor
49
8.0
100
0.12
ST14BPT1Q9Y5Y6P00974epithelialcellmorphogenesisinvolvedinplacentalbranchingkeratinocytedifferentiationneuraltubeclosureproteincatabolicprocessproteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Leukocyte immunoglobulin-like receptor subfamily A member 2
195
Leukocyte immunoglobulin-like receptor subfamily A member 2
155
8.0
78
0.16
LIRA2LIRA2Q8N149Q8N149cytokine-mediatedsignalingpathwaydefenseresponseinnateimmuneresponseinnateimmuneresponseactivatingcellsurfacereceptorsignalingpathwaynegativeregulationoflipopolysaccharide-mediatedsignalingpathwaynegativeregulationoftoll-likereceptor4signalingpathwayneutrophilactivationinvolvedinimmuneresponsepositiveregulationofcalciumiontransportpositiveregulationofcellactivationpositiveregulationofgranulocytecolony-stimulatingfactorproductionpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationoftumornecrosisfactorproductionsignaltransduction
Lethal(3)malignant brain tumor-like protein 2
531
Lethal(3)malignant brain tumor-like protein 2
531
7.8
53
0.24
LMBL2LMBL2Q969R5Q969R5chromatinorganizationnegativeregulationoftranscriptionDNA-templated
Elafin
109
Elafin
83
7.8
70
0.18
ELAFELAFP19957P19957antibacterialhumoralresponsecopulationinnateimmuneresponsepeptidecross-linking
Transcription regulator protein BACH2
20
Transcription regulator protein BACH2
20
7.0
76
0.19
BACH2BACH2Q9BYV9Q9BYV9importintonucleusnegativeregulationoftranscriptionbyRNApolymeraseIIprimaryadaptiveimmuneresponseinvolvingTcellsandBcellsregulationoftranscriptionbyRNApolymeraseII
C-C motif chemokine 8
59
C-C motif chemokine 8
34
8.0
64
0.19
CCL8CCL8P80075P80075antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecalciumiontransportcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiseosinophilchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisnegativeregulationbyhostofviralgenomereplicationnegativeregulationofleukocyteproliferationneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofleukocytemigrationresponsetovirussignaltransduction
Protein PML
72
Protein PML
72
7.0
67
0.21
PMLPMLP29590P29590activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocessbranchinginvolvedinmammaryglandductmorphogenesiscellfatecommitmentcellularresponsetointerleukin-4cellularresponsetoleukemiainhibitoryfactorcellularsenescencecircadianregulationofgeneexpressioncommon-partnerSMADproteinphosphorylationDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestendoplasmicreticulumcalciumionhomeostasisentrainmentofcircadianclockbyphotoperiodextrinsicapoptoticsignalingpathwayfibroblastmigrationinnateimmuneresponseintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressintrinsicapoptoticsignalingpathwayinresponsetooxidativestressmaintenanceofproteinlocationinnucleusmyeloidcelldifferentiationnegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofinterleukin-1betaproductionnegativeregulationofmitoticcellcyclenegativeregulationoftelomeraseactivitynegativeregulationoftelomeremaintenanceviatelomerasenegativeregulationoftranscriptionDNA-templatednegativeregulationoftranslationinresponsetooxidativestressnegativeregulationofubiquitin-dependentproteincatabolicprocessoncogene-inducedcellsenescencePMLbodyorganizationpositiveregulationofapoptoticprocessinvolvedinmammaryglandinvolutionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationoffibroblastproliferationpositiveregulationofhistonedeacetylationpositiveregulationofpeptidyl-lysineacetylationpositiveregulationofproteinlocalizationtochromosometelomericregionpositiveregulationofsignaltransductionbyp53classmediatorpositiveregulationoftelomeremaintenancepositiveregulationoftranscriptionDNA-templatedproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinimportintonucleusproteinstabilizationproteintargetingprotein-containingcomplexassemblyprotein-containingcomplexlocalizationregulationofcalciumiontransportintocytosolregulationofcelladhesionregulationofcellcycleregulationofcircadianrhythmregulationofdouble-strandbreakrepairregulationoftranscriptionDNA-templatedresponsetocytokineresponsetogammaradiationresponsetohypoxiaresponsetoUVretinoicacidreceptorsignalingpathwaysuppressionofviralreleasebyhosttransforminggrowthfactorbetareceptorsignalingpathway
G-protein-signaling modulator 2
604
G-protein-signaling modulator 2
125
7.8
72
0.18
GPSM2GPSM2Q8VDU0Q8VDU0celldivisionestablishmentofmitoticspindleorientationmaintenanceofcentrosomelocationmitoticspindleorganizationpositiveregulationofproteinlocalizationtocellcortexpositiveregulationofspindleassemblyRanproteinsignaltransductionregulationofmitoticspindleorganization
Ras-related protein Rab-8A
123
Ras-related protein Rab-8A
123
8.0
86
0.14
RAB8ARAB8AP61006P61006autophagyaxonogenesiscellularresponsetoinsulinstimulusciliumassemblyendocyticrecyclingGolgiorganizationGolgivesiclefusiontotargetmembraneneurotransmitterreceptortransporttopostsynapticmembraneneurotransmitterreceptortransportendosometopostsynapticmembraneproteinlocalizationtociliumproteinlocalizationtoplasmamembraneproteinsecretionregulationofautophagyregulationofexocytosisregulationoflong-termneuronalsynapticplasticityregulationofproteintransportvesicledockinginvolvedinexocytosisvesicle-mediatedtransportinsynapse
Gamma-crystallin S
25
Gamma-crystallin S
23
8.0
66
0.19
CRYGSCRYGSP22914P22914lensdevelopmentincamera-typeeyemorphogenesisofanepitheliumvisualperception
Guanine nucleotide-binding protein G(t) subunit alpha-1
210
Guanine nucleotide-binding protein G(t) subunit alpha-1
62
8.0
66
0.19
GNAT1GNAT1P04695P04695adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellpopulationproliferationcellularresponsetoelectricalstimulusdetectionoflightstimulusinvolvedinvisualperceptioneyephotoreceptorcelldevelopmentGprotein-coupledadenosinereceptorsignalingpathwaynegativeregulationofcyclic-nucleotidephosphodiesteraseactivityphototransductionphototransductionvisiblelightresponsetolightstimulusretinadevelopmentincamera-typeeyesensoryperceptionofumamitaste
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
492
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
488
8.4
73
0.16
PDE10PDE10Q9Y233Q9Y233cAMPcatabolicprocesscGMPcatabolicprocessnegativeregulationofcGMP-mediatedsignalingsignaltransduction
Proteasome subunit beta type-10
70
Proteasome subunit beta type-3
129
8.0
70
0.18
PSB10PSB3O35955Q9R1P1cellmorphogenesisproteasomalproteincatabolicprocessTcellproliferationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteincatabolicprocess
Acetyl-coenzyme A thioesterase
51
Acetyl-coenzyme A thioesterase
270
7.0
77
0.19
ACO12ACO12Q8WYK0Q8WYK0acetyl-CoAmetabolicprocessacyl-CoAmetabolicprocessfattyacidmetabolicprocess
NAD(P)H-hydrate epimerase
277
NAD(P)H-hydrate epimerase
277
8.0
80
0.16
NNRENNREQ8K4Z3Q8K4Z3lipidtransportmembraneraftdistributionnegativeregulationofangiogenesisnicotinamidenucleotidemetabolicprocessregulationofcholesteroleffluxsproutingangiogenesis
Kelch-like protein 11
77
Kelch-like protein 11
77
7.6
70
0.19
KLH11KLH11Q9NVR0Q9NVR0
Glutaredoxin-related protein 5, mitochondrial
67
Glutaredoxin-related protein 5, mitochondrial
67
6.9
61
0.24
GLRX5GLRX5Q86SX6Q86SX62Fe-2Sclusterassemblycellredoxhomeostasishemopoiesisironionhomeostasisiron-sulfurclusterassemblyproteinmaturationby2Fe-2Sclustertransferproteinmaturationby4Fe-4Sclustertransfer
Progesterone receptor
603
Progesterone receptor
609
6.9
65
0.22
PRGRPRGRP06401P06401cell-cellsignalingglandularepithelialcellmaturationintracellularsteroidhormonereceptorsignalingpathwaylungalveolusdevelopmentnegativeregulationofgeneexpressionovulationfromovarianfollicleparacrinesignalingpositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronereceptorsignalingpathwayregulationofepithelialcellproliferationregulationoftranscriptionbyRNApolymeraseIIsignaltransductiontertiarybranchinginvolvedinmammaryglandductmorphogenesis
V(D)J recombination-activating protein 1
431
V(D)J recombination-activating protein 1
431
7.5
76
0.17
RAG1RAG1P15919P15919adaptiveimmuneresponseBcelldifferentiationchromatinorganizationDNArecombinationhistonemonoubiquitinationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofTcellapoptoticprocessnegativeregulationofthymocyteapoptoticprocesspositiveregulationofTcelldifferentiationpre-BcellallelicexclusionproteinautoubiquitinationregulationofbehavioralfearresponseregulationofTcelldifferentiationTcelldifferentiationinthymusTcellhomeostasisthymusdevelopmentV(D)Jrecombinationvisuallearning
Serine protease 1
64
Tissue factor pathway inhibitor 2
45
8.5
94
0.12
TRY1TFPI2P00760P48307digestionproteolysisbloodcoagulationcellularresponsetofluidshearstress
Trypsin
49
Antileukoproteinase
96
7.5
95
0.14
TRYPSLPIP00761P03973digestionproteolysisantibacterialhumoralresponseimmuneresponseinnateimmuneresponsemodulationofprocessofanotherorganismnegativeregulationofproteinbindingnegativeregulationofviralgenomereplicationresponsetolipopolysaccharide
Sequestosome-1
145
Sequestosome-1
145
7.5
43
0.31
SQSTMSQSTMQ13501Q13501aggrephagyapoptoticprocessautophagyautophagyofmitochondrionbrownfatcellproliferationcelldifferentiationendosomaltransportendosomeorganizationenergyhomeostasisimmunesystemprocessintracellularsignaltransductionmacroautophagymitophagynegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofapoptoticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinimportintonucleusproteinlocalizationproteinlocalizationtoperinuclearregionofcytoplasmproteinphosphorylationregulationofI-kappaBkinase/NF-kappaBsignalingregulationofmitochondrionorganizationregulationofproteincomplexstabilityregulationofRasproteinsignaltransductionresponsetoischemiaresponsetomitochondrialdepolarisationselectiveautophagytemperaturehomeostasistranscriptionbyRNApolymeraseIIubiquitin-dependentproteincatabolicprocess
G-protein-signaling modulator 2
161
Nuclear mitotic apparatus protein 1
1907
6.9
54
0.27
GPSM2NUMA1P81274Q14980celldivisionestablishmentofmitoticspindleorientationGprotein-coupledreceptorsignalingpathwaymaintenanceofcentrosomelocationmitoticspindleorganizationpositiveregulationofproteinlocalizationtocellcortexpositiveregulationofspindleassemblyRanproteinsignaltransductionregulationofmitoticspindleorganizationanastralspindleassemblyastralmicrotubuleorganizationchromosomesegregationmeioticcellcyclemicrotubulebundleformationnucleusorganizationpositiveregulationofBMPsignalingpathwaypositiveregulationofchromosomesegregationpositiveregulationofchromosomeseparationpositiveregulationofhairfollicledevelopmentpositiveregulationofintracellulartransportpositiveregulationofkeratinocytedifferentiationpositiveregulationofmicrotubulepolymerizationpositiveregulationofmitoticspindleelongationpositiveregulationofproteinlocalizationtospindlepolebodyregulationofmetaphaseplatecongression
Prostasin
86
Pancreatic trypsin inhibitor
49
8.3
95
0.13
PRSS8BPT1Q16651P00974positiveregulationofsodiumiontransportproteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Kinesin-like protein KIF21A
1006
Kinesin-like protein KIF21A
1006
7.0
73
0.19
KI21AKI21AQ7Z4S6Q7Z4S6microtubule-basedmovement
Trypsin
49
Antileukoproteinase
122
7.5
87
0.15
TRYPSLPIP00761P03973digestionproteolysisantibacterialhumoralresponseimmuneresponseinnateimmuneresponsemodulationofprocessofanotherorganismnegativeregulationofproteinbindingnegativeregulationofviralgenomereplicationresponsetolipopolysaccharide
ADP-ribosylation factor-binding protein GGA1
77
ADP-ribosylation factor-binding protein GGA1
73
7.0
75
0.19
GGA1GGA1Q9UJY5Q9UJY5GolgitoplasmamembraneproteintransportGolgitoplasmamembranetransportintracellularproteintransportpositiveregulationofproteincatabolicprocessproteincatabolicprocessproteinlocalizationproteinlocalizationtocellsurfaceproteinlocalizationtociliarymembraneretrogradetransportendosometoGolgitoxintransport
Legumain
189
Legumain
189
6.9
100
0.14
LGMNLGMNQ99538Q99538activationofcysteine-typeendopeptidaseactivityantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIassociativelearningcellularresponsetoamyloid-betacellularresponsetocalciumioncellularresponsetohepatocytegrowthfactorstimulusdendriticspineorganizationmemorynegativeregulationofERBBsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofmulticellularorganismgrowthnegativeregulationofneuronapoptoticprocesspositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellchemotaxispositiveregulationoflong-termsynapticpotentiationpositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxisproteolysisproteolysisinvolvedinproteincatabolicprocessreceptorcatabolicprocessrenalsystemprocessresponsetoacidicpHselfproteolysisvacuolarproteinprocessingvitaminDmetabolicprocess
Regulator of G-protein signaling 3
354
Regulator of G-protein signaling 3
315
7.5
67
0.2
RGS3RGS3P49796P49796Gprotein-coupledreceptorsignalingpathwaynegativeregulationofsignaltransductionregulationofGprotein-coupledreceptorsignalingpathwaysignaltransduction
ATP-dependent RNA helicase DHX58
559
ATP-dependent RNA helicase DHX58
559
7.5
64
0.21
DHX58DHX58Q96C10Q96C10cytoplasmicpatternrecognitionreceptorsignalingpathwayinresponsetovirusinnateimmuneresponsenegativeregulationofinnateimmuneresponsenegativeregulationofMDA-5signalingpathwaynegativeregulationofRIG-IsignalingpathwaynegativeregulationoftypeIinterferonproductionpositiveregulationofinterferon-betaproductionpositiveregulationofMDA-5signalingpathwaypositiveregulationofRIG-IsignalingpathwaypositiveregulationoftypeIinterferonproductionregulationofinnateimmuneresponseresponsetobacteriumresponsetovirus
Trypsin
33
Antileukoproteinase
96
7.8
96
0.13
TRYPSLPIP00761P03973digestionproteolysisantibacterialhumoralresponseimmuneresponseinnateimmuneresponsemodulationofprocessofanotherorganismnegativeregulationofproteinbindingnegativeregulationofviralgenomereplicationresponsetolipopolysaccharide
NACHT, LRR and PYD domains-containing protein 1 allele 2
866
NACHT, LRR and PYD domains-containing protein 1 allele 2
1013
7.8
67
0.19
NL1A2NL1A2D9I2G3D9I2G3inflammatoryresponseinnateimmuneresponseprogrammedcelldeathproteolysisregulationofapoptoticprocess
Thrombomodulin
466
Thrombomodulin
451
8.1
78
0.16
TRBMTRBMP07204P07204bloodcoagulationbloodcoagulationcommonpathwayfemalepregnancynegativeregulationofbloodcoagulationnegativeregulationoffibrinolysisnegativeregulationofplateletactivationproteolysisresponsetocAMPresponsetolipopolysaccharideresponsetoX-rayzymogenactivation
Glutamate receptor 2
78
Glutamate receptor 2
78
8.1
73
0.17
GRIA2GRIA2P42262P42262chemicalsynaptictransmissionionotropicglutamatereceptorsignalingpathwaysignaltransductionsynaptictransmissionglutamatergic
Integrator complex subunit 13
406
Integrator complex subunit 14
310
8.1
78
0.16
INT13INT14Q9NVM9Q96SY0celldivisioncentrosomelocalizationflagellatedspermmotilitymitoticspindleorganizationproteinlocalizationtonuclearenveloperegulationoffertilizationregulationofmitoticcellcycleregulationoftranscriptionelongationfromRNApolymeraseIIpromotersnRNAprocessing"snRNA3-endprocessing"
Glucocorticoid receptor
463
Glucocorticoid receptor
473
8.0
73
0.17
GCRGCRP79269P79269cellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluschromatinorganizationpositiveregulationoftranscriptionbyRNApolymeraseII
Histone deacetylase 6
1120
Histone deacetylase 6
1183
8.4
75
0.16
HDAC6HDAC6Q9UBN7Q9UBN7aggresomeassemblyautophagyaxonaltransportofmitochondrioncellularresponsetohydrogenperoxidecellularresponsetomisfoldedproteincellularresponsetotopologicallyincorrectproteinciliumassemblyciliumdisassemblycollateralsproutingdendriticspinemorphogenesishistonedeacetylationHsp90deacetylationintracellularproteintransportlysosomelocalizationnegativeregulationofhydrogenperoxidemetabolicprocessnegativeregulationofmicrotubuledepolymerizationnegativeregulationofoxidoreductaseactivitynegativeregulationofprotein-containingcomplexassemblynegativeregulationofprotein-containingcomplexdisassemblynegativeregulationofproteolysisnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedparkin-mediatedstimulationofmitophagyinresponsetomitochondrialdepolarizationpeptidyl-lysinedeacetylationpolyubiquitinatedmisfoldedproteintransportpositiveregulationofepithelialcellmigrationpositiveregulationofhydrogenperoxide-mediatedprogrammedcelldeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsignalingreceptoractivityproteindeacetylationproteindestabilizationproteinpolyubiquitinationproteinqualitycontrolformisfoldedorincompletelysynthesizedproteinsprotein-containingcomplexdisassemblyregulationofandrogenreceptorsignalingpathwayregulationofautophagyregulationofautophagyofmitochondrionregulationofestablishmentofproteinlocalizationregulationoffatcelldifferentiationregulationofgeneexpressionepigeneticregulationofmacroautophagyregulationofmicrotubule-basedmovementregulationofproteinstabilityresponsetogrowthfactorresponsetomisfoldedproteintubulindeacetylationubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathway
Protein kinase C delta type
264
Protein kinase C delta type
247
8.0
64
0.2
A0A140UHX0A0A140UHX0A0A140UHX0A0A140UHX0apoptoticprocesscellcycleproteinphosphorylation
E3 ubiquitin-protein ligase TRIM37
66
E3 ubiquitin-protein ligase TRIM37
66
8.1
72
0.17
TRI37TRI37O94972O94972aggresomeassemblyhistoneH2AmonoubiquitinationhistoneH2A-K119monoubiquitinationnegativeregulationofcentriolereplicationnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofNF-kappaBtranscriptionfactoractivityproteinautoubiquitination
Protocadherin-15
268
Protocadherin-15
268
8.1
67
0.18
PCD15PCD15Q96QU1Q96QU1celladhesionequilibrioceptionhomophiliccelladhesionviaplasmamembraneadhesionmoleculesinnereardevelopmentphotoreceptorcellmaintenancesensoryperceptionoflightstimulussensoryperceptionofsound
Inosine triphosphate pyrophosphatase
146
Inosine triphosphate pyrophosphatase
146
6.8
78
0.19
ITPAITPAQ9BY32Q9BY32chromosomeorganizationdeoxyribonucleosidetriphosphatecatabolicprocessITPcatabolicprocessnucleosidetriphosphatecatabolicprocess
C-C motif chemokine 13
34
C-C motif chemokine 13
58
6.8
63
0.23
CCL13CCL13Q99616Q99616antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytoskeletonorganizationeosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivityregulationofcellshapesignaltransduction
Trypsin
33
Antileukoproteinase
122
8.1
88
0.14
TRYPSLPIP00761P03973digestionproteolysisantibacterialhumoralresponseimmuneresponseinnateimmuneresponsemodulationofprocessofanotherorganismnegativeregulationofproteinbindingnegativeregulationofviralgenomereplicationresponsetolipopolysaccharide
E3 ubiquitin-protein ligase TRIM7
378
E3 ubiquitin-protein ligase TRIM7
378
8.1
73
0.17
TRIM7TRIM7Q9C029Q9C029proteinubiquitination
Suppressor of tumorigenicity 14 protein
657
Kunitz-type protease inhibitor 1
259
8.1
101
0.12
ST14SPIT1Q9Y5Y6O43278epithelialcellmorphogenesisinvolvedinplacentalbranchingkeratinocytedifferentiationneuraltubeclosureproteincatabolicprocessproteolysisbranchinginvolvedinlabyrinthinelayermorphogenesiscellularresponsetoBMPstimulusepidermisdevelopmentepitheliumdevelopmentextracellularmatrixorganizationnegativeregulationofneuralprecursorcellproliferationplacentabloodvesseldevelopmentpositiveregulationofglialcelldifferentiation
Dual specificity protein phosphatase 16
50
Dual specificity protein phosphatase 16
50
8.1
77
0.16
DUS16DUS16Q9BY84Q9BY84dephosphorylationMAPKexportfromnucleusnegativeregulationofJUNkinaseactivitynegativeregulationofMAPKcascadeproteindephosphorylation
Mothers against decapentaplegic homolog 7
319
Mothers against decapentaplegic homolog 7
319
8.2
80
0.15
SMAD7SMAD7O35253O35253adherensjunctionassemblyanatomicalstructuremorphogenesisarterymorphogenesisBMPsignalingpathwaycelldifferentiationcellularresponsetoleukemiainhibitoryfactorcellularresponsetotransforminggrowthfactorbetastimulusintracellularsignaltransductionnegativeregulationofBMPsignalingpathwaynegativeregulationofchondrocyteproliferationnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofossificationnegativeregulationofpathway-restrictedSMADproteinphosphorylationnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofpeptidyl-threoninephosphorylationnegativeregulationofproteinubiquitinationnegativeregulationofTcellcytokineproductionnegativeregulationofT-helper17celldifferentiationnegativeregulationofT-helper17typeimmuneresponsenegativeregulationoftranscriptionbycompetitivepromoterbindingnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofubiquitin-proteintransferaseactivitypathway-restrictedSMADproteinphosphorylationpositiveregulationofcell-celladhesionpositiveregulationofchondrocytehypertrophypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinubiquitinationproteinstabilizationprotein-containingcomplexlocalizationregulationofactivinreceptorsignalingpathwayregulationofcardiacmusclecontractionregulationofepithelialtomesenchymaltransitionregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationofventricularcardiacmusclecellmembranedepolarizationresponsetolaminarfluidshearstressSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentventricularcardiacmuscletissuemorphogenesisventricularseptummorphogenesis
Importin subunit beta-1
436
Importin subunit beta-1
436
6.8
78
0.19
IMB1IMB1P70168P70168astralmicrotubuleorganizationestablishmentofmitoticspindlelocalizationestablishmentofproteinlocalizationmitoticchromosomemovementtowardsspindlepolemitoticmetaphaseplatecongressionmitoticspindleassemblyproteinimportintonucleusRanproteinsignaltransductionribosomalproteinimportintonucleusRNAimportintonucleus
Axin-1
121
Adenomatous polyposis coli protein
2042
8.1
74
0.17
AXIN1APCO15169P25054activationofproteinkinaseactivityapoptoticprocessaxialmesodermformationcanonicalWntsignalingpathwaycelldevelopmentcytoplasmicmicrotubuleorganizationdorsal/ventralaxisspecificationgenomicimprintingheaddevelopmentinuteroembryonicdevelopmentnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationoffatcelldifferentiationnegativeregulationofproteinmetabolicprocessnegativeregulationoftranscriptionelongationfromRNApolymeraseIIpromoternucleocytoplasmictransportpositiveregulationofJNKcascadepositiveregulationofJUNkinaseactivitypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteincatabolicprocesspositiveregulationofproteinkinaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofproteinubiquitinationpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofubiquitin-dependentproteincatabolicprocesspositiveregulationofubiquitin-proteintransferaseactivitypost-analtailmorphogenesisproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationprotein-containingcomplexassemblysensoryperceptionofsoundbicellulartightjunctionassemblycelladhesioncellfatespecificationcellmigrationcellularresponsetoDNAdamagestimulusinsulinreceptorsignalingpathwaymitoticcytokinesismitoticspindleassemblycheckpointsignalingnegativeregulationofcellcycleG1/Sphasetransitionnegativeregulationofcellpopulationproliferationnegativeregulationofcyclin-dependentproteinserine/threoninekinaseactivitynegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofmicrotubuledepolymerizationnervoussystemdevelopmentpatternspecificationprocesspositiveregulationofapoptoticprocesspositiveregulationofcelldeathpositiveregulationofcellmigrationpositiveregulationofcold-inducedthermogenesispositiveregulationofproteinlocalizationtocentrosomepositiveregulationofpseudopodiumassemblyregulationofattachmentofspindlemicrotubulestokinetochoreregulationofcelldifferentiationregulationofmicrotubule-basedprocessWntsignalingpathway
Receptor-type tyrosine-protein phosphatase N2
882
Receptor-type tyrosine-protein phosphatase N2
882
8.1
53
0.23
PTPR2PTPR2Q92932Q92932insulinsecretioninvolvedincellularresponsetoglucosestimuluslipidmetabolicprocessneurotransmittersecretionproteindephosphorylationregulationofsecretion
S-adenosylmethionine synthase isoform type-1
68
S-adenosylmethionine synthase isoform type-1
60
8.1
83
0.15
METK1METK1Q00266Q00266methioninecatabolicprocessone-carbonmetabolicprocessproteinhomotetramerizationS-adenosylmethioninebiosyntheticprocess
DCN1-like protein 1
115
DCN1-like protein 1
115
8.2
53
0.23
DCNL1DCNL1Q96GG9Q96GG9positiveregulationofproteinneddylationpositiveregulationofubiquitin-proteintransferaseactivityproteinneddylationregulationofproteinneddylationregulationofproteinubiquitination
Synembryn-A
122
Guanine nucleotide-binding protein G(t) subunit alpha-2
351
8.5
65
0.18
RIC8AGNAT2Q5E9J8P19087adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaybasementmembraneorganizationcellmigrationinvolvedingastrulationcell-celladhesioninvolvedingastrulationGprotein-coupledreceptorsignalingpathwayinuteroembryonicdevelopmentvasculaturedevelopmentvisuallearningadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaydetectionofchemicalstimulusinvolvedinsensoryperceptionofbittertastedetectionoflightstimulusinvolvedinvisualperceptionphototransductionpositiveregulationofcytosoliccalciumionconcentrationresponsetolightintensityretinalconecelldevelopmentvisualperception
Proproteinase E
196
Proproteinase E
227
8.1
96
0.13
CAC3CAC3P05805P05805digestionproteolysis
Glutamate receptor 2
78
Glutamate receptor 3
334
8.0
74
0.17
GRIA2GRIA3P19491P19492chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumion
General transcription factor IIH subunit 3
142
General transcription factor IIH subunit 2
368
8.1
75
0.16
TF2H3TF2H2Q13889Q13888DNArepairnucleotide-excisionrepairphosphorylationofRNApolymeraseIIC-terminaldomaintranscriptionbyRNApolymeraseIIGprotein-coupledreceptorinternalizationpositiveregulationofDNAhelicaseactivityregulationoftranscriptionbyRNApolymeraseIIresponsetoUVtranscriptioninitiationfromRNApolymeraseIIpromoter
DNA (cytosine-5)-methyltransferase 3A
559
DNA (cytosine-5)-methyltransferase 3A
514
8.1
81
0.15
DNM3ADNM3AQ9Y6K1Q9Y6K1agingC-5methylationofcytosinecellularresponsetoaminoacidstimuluscellularresponsetobisphenolAcellularresponsetoethanolcellularresponsetohypoxiaDNAmethylationDNAmethylationinvolvedinembryodevelopmentDNAmethylationinvolvedingametegenerationDNAmethylationoncytosineDNAmethylation-dependentheterochromatinassemblyhepatocyteapoptoticprocessmitoticcellcyclenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneurondifferentiationpositiveregulationofcelldeathregulationofgeneexpressionbygenomicimprintingresponsetococaineresponsetoestradiolresponsetoionizingradiationresponsetoleadionresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulusspermatogenesis
CCR4-NOT transcription complex subunit 7
202
Protein Tob1
57
8.1
82
0.15
CNOT7TOB1Q9UIV1P50616deadenylation-dependentdecappingofnuclear-transcribedmRNAdefenseresponsetovirusexonucleolyticcatabolismofdeadenylatedmRNAgenesilencingbyRNAmiRNA-mediatedgenesilencingnegativeregulationofcellpopulationproliferationnegativeregulationofgeneexpressionnegativeregulationoftranscriptionDNA-templatednegativeregulationoftypeIinterferon-mediatedsignalingpathwaynuclear-transcribedmRNApoly(A)tailshorteningP-bodyassemblypositiveregulationofcellpopulationproliferationpositiveregulationofmRNAcatabolicprocesspositiveregulationofnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecaypositiveregulationofnuclear-transcribedmRNApoly(A)tailshorteningpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofviralgenomereplicationregulationoftyrosinephosphorylationofSTATproteinnegativeregulationofBMPsignalingpathwaynegativeregulationofnuclear-transcribedmRNApoly(A)tailshorteningnegativeregulationofosteoblastdifferentiationnegativeregulationoftranslationregulationofgeneexpressionregulationofSMADproteinsignaltransduction
Ubl carboxyl-terminal hydrolase 18
345
Ubl carboxyl-terminal hydrolase 18
345
8.1
55
0.23
UBP18UBP18Q9WTV6Q9WTV6negativeregulationoftypeIinterferon-mediatedsignalingpathwayproteindeubiquitinationregulationofinflammatoryresponseresponsetobacteriumresponsetostilbenoidubiquitin-dependentproteincatabolicprocess
MORC family CW-type zinc finger protein 3
413
MORC family CW-type zinc finger protein 3
416
8.5
72
0.16
MORC3MORC3Q14149Q14149innateimmuneresponsemaintenanceofproteinlocationinnucleusnegativeregulationoffibroblastproliferationpeptidyl-serinephosphorylationpositiveregulationofcellularsenescencepost-embryonicdevelopmentproteinphosphorylationproteinstabilization
Prostaglandin-H2 D-isomerase
89
Prostaglandin-H2 D-isomerase
89
6.9
73
0.2
PTGDSPTGDSP41222P41222cyclooxygenasepathwaygeneexpressionmastcelldegranulationnegativeregulationofmalegermcellproliferationprostaglandinbiosyntheticprocessregulationofcircadiansleep/wakecyclesleepresponsetoglucocorticoid
Hydroxymethylglutaryl-CoA synthase, mitochondrial
454
Hydroxymethylglutaryl-CoA synthase, mitochondrial
454
8.1
66
0.19
HMCS2HMCS2P54868P54868acetyl-CoAmetabolicprocessadiposetissuedevelopmentbraindevelopmentcellularresponsetoaminoacidstimuluscellularresponsetofattyacidcellularresponsetoglucocorticoidstimuluscellularresponsetoinsulinstimuluscellularresponsetolipopolysaccharidecholesterolbiosyntheticprocessfarnesyldiphosphatebiosyntheticprocessmevalonatepathwayketonebodybiosyntheticprocesskidneydevelopmentliverdevelopmentlungdevelopmentmidgutdevelopmentmulticellularorganismalresponsetostressresponsetocAMPresponsetoethanolresponsetoglucagonresponsetogrowthhormoneresponsetolinoleicacidresponsetometalionresponsetomonosaccharideresponsetonutrientresponsetoprostaglandinFresponsetostarvationresponsetotemperaturestimulusresponsetotestosteroneresponsetotriglycerideresponsetoxenobioticstimulus
Coagulation factor XI
432
Amyloid-beta precursor protein
300
8.6
99
0.12
FA11A4P03951P05067bloodcoagulationbloodcoagulationintrinsicpathwayplasminogenactivationpositiveregulationoffibrinolysisproteolysiszymogenactivationadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
PRSS3 protein
68
Amyloid beta precursor like protein 2
343
8.1
78
0.16
Q8N2U3APLP2Q8N2U3Q06481proteolysisaxonogenesiscentralnervoussystemdevelopmentGprotein-coupledreceptorsignalingpathwayregulationofcellularproteinmetabolicprocess
Neutrophil elastase
55
Antileukoproteinase
122
8.0
85
0.15
ELNESLPIP08246P03973acuteinflammatoryresponsetoantigenicstimulusbiosyntheticprocessofantibacterialpeptidesactiveagainstGram-negativebacteriacellularcalciumionhomeostasisdefenseresponsetobacteriumextracellularmatrixdisassemblyleukocytemigrationinvolvedininflammatoryresponsenegativeregulationofchemokineproductionnegativeregulationofchemotaxisnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-8productionnegativeregulationoftranscriptionbyRNApolymeraseIIneutrophil-mediatedkillingoffungusneutrophil-mediatedkillingofgram-negativebacteriumphagocytosispositiveregulationofimmuneresponsepositiveregulationofinterleukin-8productionpositiveregulationofleukocytetetheringorrollingpositiveregulationofMAPkinaseactivitypositiveregulationofsmoothmusclecellproliferationproteincatabolicprocessproteolysispyroptosisresponsetolipopolysaccharideresponsetoUVresponsetoyeastantibacterialhumoralresponseimmuneresponseinnateimmuneresponsemodulationofprocessofanotherorganismnegativeregulationofproteinbindingnegativeregulationofviralgenomereplication
Threonine aspartase 1
271
Threonine aspartase 1
271
8.0
97
0.13
TASP1TASP1Q9H6P5Q9H6P5positiveregulationoftranscriptionDNA-templatedproteinmaturationproteolysis
Squalene monooxygenase
558
Squalene monooxygenase
558
8.0
66
0.19
ERG1ERG1Q14534Q14534cellulararomaticcompoundmetabolicprocesscholesterolmetabolicprocesslipiddropletformationregulationofcellpopulationproliferationresponsetoorganicsubstancesterolbiosyntheticprocess
Interleukin-10
132
Interleukin-10
132
8.0
76
0.16
IL10IL10P18893P18893agingbranchinginvolvedinlabyrinthinelayermorphogenesiscellularresponsetoestradiolstimuluscellularresponsetohepatocytegrowthfactorstimuluscellularresponsetolipopolysaccharidechronicinflammatoryresponsetoantigenicstimulusdefenseresponsetobacteriumdefenseresponsetoprotozoanimmuneresponseliverregenerationnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofBcellproliferationnegativeregulationofcellpopulationproliferationnegativeregulationofchronicinflammatoryresponsetoantigenicstimulusnegativeregulationofcytokineactivitynegativeregulationofcytokineproductionnegativeregulationofcytokineproductioninvolvedinimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofheterotypiccell-celladhesionnegativeregulationofhydrogenperoxide-inducedneurondeathnegativeregulationofinflammatoryresponsenegativeregulationofinterferon-gammaproductionnegativeregulationofinterleukin-12productionnegativeregulationofinterleukin-6productionnegativeregulationofmembraneproteinectodomainproteolysisnegativeregulationofMHCclassIIbiosyntheticprocessnegativeregulationofmyeloiddendriticcellactivationnegativeregulationofneuronapoptoticprocessnegativeregulationofnitricoxidebiosyntheticprocessnegativeregulationofsensoryperceptionofpainnegativeregulationoftumornecrosisfactorproductionnegativeregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofBcellapoptoticprocesspositiveregulationofcellcyclepositiveregulationofcytokineproductionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellproliferationpositiveregulationofimmunoglobulinproductionpositiveregulationofmacrophageactivationpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofmiRNAtranscriptionpositiveregulationofplasmacelldifferentiationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsignalingreceptoractivitypositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofgeneexpressionregulationofresponsetowoundingregulationofsensoryperceptionofpainregulationofsynapseorganizationresponsetoactivityresponsetocarbonmonoxideresponsetoglucocorticoidresponsetoinactivityresponsetoinsulinresponsetomoleculeofbacterialoriginresponsetoxenobioticstimulus
Ubl carboxyl-terminal hydrolase 18
336
Ubl carboxyl-terminal hydrolase 18
329
8.4
74
0.16
UBP18UBP18Q9WTV6Q9WTV6negativeregulationoftypeIinterferon-mediatedsignalingpathwayproteindeubiquitinationregulationofinflammatoryresponseresponsetobacteriumresponsetostilbenoidubiquitin-dependentproteincatabolicprocess
Polyunsaturated fatty acid 5-lipoxygenase
301
Polyunsaturated fatty acid 5-lipoxygenase
450
7.7
55
0.24
LOX5LOX5P09917P09917arachidonicacidmetabolicprocessdendriticcellmigrationglucosehomeostasishepoxilinbiosyntheticprocesshumoralimmuneresponseleukocytechemotaxisinvolvedininflammatoryresponseleukocytemigrationinvolvedininflammatoryresponseleukotrieneA4biosyntheticprocessleukotrienebiosyntheticprocessleukotrienemetabolicprocessleukotrieneproductioninvolvedininflammatoryresponselinoleicacidmetabolicprocesslipidoxidationlipoxinbiosyntheticprocesslipoxygenasepathwaylong-chainfattyacidbiosyntheticprocessnegativeregulationofangiogenesisnegativeregulationofendothelialcellproliferationnegativeregulationofinflammatoryresponsenegativeregulationofresponsetoendoplasmicreticulumstressnegativeregulationofsproutingangiogenesisnegativeregulationofvascularwoundhealingnegativeregulationofwoundhealingpositiveregulationofbonemineralizationpositiveregulationofleukocyteadhesiontoarterialendothelialcellregulationofcellularresponsetooxidativestressregulationofcytokineproductioninvolvedininflammatoryresponseregulationoffatcelldifferentiationregulationofinflammatoryresponseregulationofinflammatoryresponsetowoundingregulationofinsulinsecretionregulationofreactiveoxygenspeciesbiosyntheticprocess
Protein kinase C delta type
272
Protein kinase C delta type
264
7.7
65
0.2
A0A140UHX0A0A140UHX0A0A140UHX0A0A140UHX0apoptoticprocesscellcycleproteinphosphorylation
Histone-lysine N-methyltransferase 2C
1081
Histone-lysine N-methyltransferase 2C
1081
7.9
74
0.17
KMT2CKMT2CQ8NEZ4Q8NEZ4chromatinorganizationhistoneH3-K4methylationhistoneH3-K4monomethylationpositiveregulationoftranscriptionbyRNApolymeraseII
Origin recognition complex subunit 1
829
Origin recognition complex subunit 4
194
7.7
81
0.16
ORC1ORC4Q13415O43929DNAreplicationinitiationmitoticDNAreplicationcheckpointsignaling
Trypsin
49
Tissue factor pathway inhibitor
134
7.9
95
0.13
TRYPTFPI1P00761P10646digestionproteolysisbloodcoagulationcellularresponsetosteroidhormonestimulusnegativeregulationofbloodcoagulation
E3 ubiquitin-protein ligase parkin
360
E3 ubiquitin-protein ligase parkin
323
7.8
73
0.18
PRKNPRKNQ9JK66Q9JK66adultlocomotorybehavioraggresomeassemblyautophagyofmitochondrionbraindevelopmentcellularresponsetohydrogensulfidecellularresponsetoL-glutamatecellularresponsetoL-glutaminecellularresponsetomanganeseioncellularresponsetotoxicsubstancedopaminemetabolicprocessdopamineuptakeinvolvedinsynaptictransmissionfreeubiquitinchainpolymerizationlearninglocomotorybehaviormitochondrialfissionmitochondrialfragmentationinvolvedinapoptoticprocessmitochondrionlocalizationmitochondrionorganizationmitochondriontolysosometransportmitophagymodulationofchemicalsynaptictransmissionnegativeregulationbyhostofviralgenomereplicationnegativeregulationofactinfilamentbundleassemblynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcelldeathnegativeregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofendoplasmicreticulumstress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofexcitatorypostsynapticpotentialnegativeregulationofexosomalsecretionnegativeregulationofgeneexpressionnegativeregulationofglucokinaseactivitynegativeregulationofinsulinsecretionnegativeregulationofintralumenalvesicleformationnegativeregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatornegativeregulationofJNKcascadenegativeregulationofmitochondrialfissionnegativeregulationofmitochondrialfusionnegativeregulationofneuronapoptoticprocessnegativeregulationofneurondeathnegativeregulationofoxidativestress-inducedneurondeathnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofprimaryamineoxidaseactivitynegativeregulationofproteinphosphorylationnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofspontaneousneurotransmittersecretionnegativeregulationofsynaptictransmissionglutamatergicnegativeregulationoftranscriptionbyRNApolymeraseIIneuroncellularhomeostasisnorepinephrinemetabolicprocessparkin-mediatedstimulationofmitophagyinresponsetomitochondrialdepolarizationpositiveregulationofapoptoticprocesspositiveregulationofATPbiosyntheticprocesspositiveregulationofautophagyofmitochondrionpositiveregulationofdendriteextensionpositiveregulationofDNAbindingpositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofmitochondrialfissionpositiveregulationofmitochondrialfusionpositiveregulationofmitochondrialmembranepotentialpositiveregulationofmitophagypositiveregulationofmitophagyinresponsetomitochondrialdepolarizationpositiveregulationofneurotransmitteruptakepositiveregulationofproteasomalproteincatabolicprocesspositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinbindingpositiveregulationofproteinlinearpolyubiquitinationpositiveregulationofproteinlocalizationtomembranepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayproteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautoubiquitinationproteindestabilizationproteinK11-linkedubiquitinationproteinK48-linkedubiquitinationproteinK6-linkedubiquitinationproteinK63-linkedubiquitinationproteinlocalizationtomitochondrionproteinmetabolicprocessproteinmonoubiquitinationproteinpolyubiquitinationproteinstabilizationproteinubiquitinationregulationofapoptoticprocessregulationofautophagyregulationofcellularresponsetooxidativestressregulationofdopaminemetabolicprocessregulationofgeneexpressionregulationofmitochondrialmembranepotentialregulationofmitochondrionorganizationregulationofneurotransmittersecretionregulationofproteinstabilityregulationofproteinubiquitinationregulationofreactiveoxygenspeciesmetabolicprocessresponsetocorticosteroneresponsetocurcuminresponsetoendoplasmicreticulumstressresponsetomuscleactivityresponsetooxidativestressresponsetounfoldedproteinresponsetoxenobioticstimulusstartleresponsesynaptictransmissiondopaminergicsynaptictransmissionglutamatergicubiquitin-dependentproteincatabolicprocesszincionhomeostasis
Isoform L-VEGF206 of Vascular endothelial growth factor A
274
Isoform L-VEGF206 of Vascular endothelial growth factor A
257
8.7
64
0.18
VEGFAVEGFAP15692-14P15692-14
Importin subunit alpha
419
Importin subunit alpha
419
7.8
70
0.18
H0VVB1H0VVB1H0VVB1H0VVB1entryofviralgenomeintohostnucleusthroughnuclearporecomplexviaimportinNLS-bearingproteinimportintonucleuspositiveregulationofvirallifecyclepostsynapsetonucleussignalingpathway
Peroxiredoxin-5, mitochondrial
204
Peroxiredoxin-5, mitochondrial
100
7.4
70
0.19
PRDX5PRDX5P30044P30044cellredoxhomeostasiscellularresponsetooxidativestresscellularresponsetoreactiveoxygenspecieshydrogenperoxidecatabolicprocessinflammatoryresponseNADPHoxidationnegativeregulationofapoptoticprocessnegativeregulationofoxidoreductaseactivitynegativeregulationoftranscriptionbyRNApolymeraseIIIpositiveregulationofcollagenbiosyntheticprocessreactivenitrogenspeciesmetabolicprocessregulationofapoptosisinvolvedintissuehomeostasisresponsetooxidativestress
Glutamate receptor 2
78
Glutamate receptor 4
84
7.9
75
0.17
GRIA2GRIA4P19491P19493chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumionmodulationofchemicalsynaptictransmissionnegativeregulationofsmoothmusclecellapoptoticprocesspositiveregulationofsynaptictransmissionglutamatergicregulationofsynapsestructureoractivity
ATP-dependent RNA helicase DHX58
559
ATP-dependent RNA helicase DHX58
615
7.4
62
0.22
DHX58DHX58Q96C10Q96C10cytoplasmicpatternrecognitionreceptorsignalingpathwayinresponsetovirusinnateimmuneresponsenegativeregulationofinnateimmuneresponsenegativeregulationofMDA-5signalingpathwaynegativeregulationofRIG-IsignalingpathwaynegativeregulationoftypeIinterferonproductionpositiveregulationofinterferon-betaproductionpositiveregulationofMDA-5signalingpathwaypositiveregulationofRIG-IsignalingpathwaypositiveregulationoftypeIinterferonproductionregulationofinnateimmuneresponseresponsetobacteriumresponsetovirus
Elafin
109
Elafin
109
7.4
64
0.21
ELAFELAFP19957P19957antibacterialhumoralresponsecopulationinnateimmuneresponsepeptidecross-linking
Kunitz-type protease inhibitor 2
47
Trypsin-3
121
8.4
93
0.13
SPIT2TRY3O43291P35030basementmembraneorganizationcellularresponsetoBMPstimulusepithelialcellmorphogenesisinvolvedinplacentalbranchingestablishmentormaintenanceofcellpolaritynegativeregulationofcellmotilitynegativeregulationofcell-celladhesionnegativeregulationofneuralprecursorcellproliferationneuraltubeclosureantimicrobialhumoralresponsedigestionendothelialcellmigrationproteolysiszymogenactivation
Neutrophil elastase
55
Antileukoproteinase
96
8.0
94
0.13
ELNESLPIP08246P03973acuteinflammatoryresponsetoantigenicstimulusbiosyntheticprocessofantibacterialpeptidesactiveagainstGram-negativebacteriacellularcalciumionhomeostasisdefenseresponsetobacteriumextracellularmatrixdisassemblyleukocytemigrationinvolvedininflammatoryresponsenegativeregulationofchemokineproductionnegativeregulationofchemotaxisnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-8productionnegativeregulationoftranscriptionbyRNApolymeraseIIneutrophil-mediatedkillingoffungusneutrophil-mediatedkillingofgram-negativebacteriumphagocytosispositiveregulationofimmuneresponsepositiveregulationofinterleukin-8productionpositiveregulationofleukocytetetheringorrollingpositiveregulationofMAPkinaseactivitypositiveregulationofsmoothmusclecellproliferationproteincatabolicprocessproteolysispyroptosisresponsetolipopolysaccharideresponsetoUVresponsetoyeastantibacterialhumoralresponseimmuneresponseinnateimmuneresponsemodulationofprocessofanotherorganismnegativeregulationofproteinbindingnegativeregulationofviralgenomereplication
Uromodulin
425
Uromodulin
425
8.0
94
0.13
UROMUROMP07911P07911apoptoticsignalingpathwayautophagycellularcalciumionhomeostasiscellularchlorideionhomeostasiscellulardefenseresponsecellularphosphateionhomeostasiscellularresponsetounfoldedproteincellularsodiumionhomeostasischaperone-mediatedproteinfoldingcitricacidsecretioncollectingductdevelopmentconnectivetissuereplacementcreatininehomeostasisdefenseresponsetoGram-negativebacteriumendoplasmicreticulumorganizationglomerularfiltrationheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesinflammatoryresponsejuxtaglomerularapparatusdevelopmentleukocytecell-celladhesionlipidmetabolicprocessmetanephricascendingthinlimbdevelopmentmetanephricdistalconvolutedtubuledevelopmentmetanephricthickascendinglimbdevelopmentmicturitionmulticellularorganismalresponsetostressnegativeregulationofcellpopulationproliferationneutrophilmigrationorganortissuespecificimmuneresponsepeptidyl-threoninephosphorylationpotassiumionhomeostasisproteinlocalizationtovacuoleproteintransportintoplasmamembraneraftregulationofbloodpressureregulationofproteintransportregulationofurinevolumerenalsodiumionabsorptionrenaluratesaltexcretionrenalwaterhomeostasisresponsetolipopolysaccharideresponsetowaterdeprivationresponsetoxenobioticstimulusRNAsplicingtumornecrosisfactor-mediatedsignalingpathwayubiquitin-dependentERADpathwayuratetransportureatransmembranetransport
Brain-derived neurotrophic factor
239
Neurotrophin-3
248
7.7
90
0.14
BDNFNTF3P23560P20783axonguidancebrain-derivedneurotrophicfactorreceptorsignalingpathwaycollateralsproutingmemorymodulationofchemicalsynaptictransmissionnegativeregulationofapoptoticsignalingpathwaynegativeregulationofmyotubedifferentiationnegativeregulationofneuronapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwaynervoussystemdevelopmentneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofbrain-derivedneurotrophicfactorreceptorsignalingpathwaypositiveregulationofcollateralsproutingpositiveregulationofneuronprojectiondevelopmentpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofreceptorbindingpositiveregulationofsynapseassemblyregulationofneurondifferentiationregulationofproteinlocalizationtocellsurfacesynapseassemblytransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofGTPaseactivityactivationofproteinkinaseBactivitycell-cellsignalinginductionofpositivechemotaxisnegativeregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofactincytoskeletonreorganizationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofreceptorinternalizationregulationofapoptoticprocesssignaltransduction
Spondin-1
156
Spondin-1
156
8.0
68
0.18
SPON1SPON1Q9HCB6Q9HCB6celladhesionnegativeregulationofamyloid-betaformationpositiveregulationofamyloidprecursorproteincatabolicprocesspositiveregulationofproteinbindingpositiveregulationofproteinprocessingproteinprocessing
Neurotrophin-3
248
Neurotrophin-3
248
7.7
90
0.14
NTF3NTF3P20783P20783activationofGTPaseactivityactivationofproteinkinaseBactivitycell-cellsignalinginductionofpositivechemotaxismemorymodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnegativeregulationofpeptidyl-tyrosinephosphorylationnervedevelopmentnervegrowthfactorsignalingpathwaynervoussystemdevelopmentneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofactincytoskeletonreorganizationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofreceptorinternalizationregulationofapoptoticprocessregulationofneurondifferentiationsignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
Poly [ADP-ribose] polymerase tankyrase-1
1245
Poly [ADP-ribose] polymerase tankyrase-1
1242
8.3
63
0.19
TNKS1TNKS1O95271O95271celldivisionmitoticspindleorganizationmRNAtransportnegativeregulationofmaintenanceofmitoticsisterchromatidcohesiontelomericnegativeregulationoftelomeremaintenanceviatelomerelengtheningnegativeregulationoftelomericDNAbindingpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationoftelomeraseactivitypositiveregulationoftelomerecappingpositiveregulationoftelomeremaintenanceviatelomerasepositiveregulationoftranscriptionbyRNApolymeraseIIproteinADP-ribosylationproteinauto-ADP-ribosylationproteinlocalizationtochromosometelomericregionproteinpoly-ADP-ribosylationproteinpolyubiquitinationproteintransportregulationoftelomeremaintenanceviatelomerasespindleassemblyWntsignalingpathway
Glutamate receptor 1
75
Glutamate receptor 1
75
7.7
78
0.17
GRIA1GRIA1P19490P19490cellularresponsetoaminestimuluscellularresponsetoaminoacidstimuluscellularresponsetoammoniumioncellularresponsetodsRNAcellularresponsetogrowthfactorstimuluscellularresponsetoorganiccycliccompoundcellularresponsetopeptidehormonestimuluschemicalsynaptictransmissionlong-termmemorylong-termsynapticdepressionmodulationofchemicalsynaptictransmissionneuronalactionpotentialpositiveregulationofmembranepotentialpositiveregulationofsynaptictransmissionreceptorinternalizationregulationofpostsynapticmembranepotentialregulationofreceptorrecyclingregulationofsynapticplasticityresponsetoarsenic-containingsubstanceresponsetococaineresponsetoelectricalstimulusresponsetoestradiolresponsetofungicideresponsetolithiumionresponsetoorganiccycliccompoundresponsetopeptidehormoneresponsetotoxicsubstanceresponsetoxenobioticstimulusspinalcorddevelopmentsynaptictransmissionglutamatergic
E3 ubiquitin-protein ligase RNF13
281
E3 ubiquitin-protein ligase RNF13
266
8.0
68
0.19
RNF13RNF13O43567O43567organellelocalizationpositiveregulationofstress-activatedproteinkinasesignalingcascadeproteinautoubiquitinationubiquitin-dependentproteincatabolicprocess
Mothers against decapentaplegic homolog 4
71
Mothers against decapentaplegic homolog 4
71
8.6
82
0.14
SMAD4SMAD4Q13485Q13485activinreceptorsignalingpathwayadrenalglanddevelopmentaginganatomicalstructuremorphogenesisatrioventricularcanaldevelopmentatrioventricularvalveformationaxonguidanceBMPsignalingpathwaybrainstemdevelopmentbranchinginvolvedinuretericbudmorphogenesiscardiacconductionsystemdevelopmentcelldifferentiationcellpopulationproliferationcellularironionhomeostasiscellularresponsetoBMPstimuluscellularresponsetoglucosestimulusdevelopmentalgrowthembryonicdigitmorphogenesisendocardialcelldifferentiationendothelialcellactivationepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationERK1andERK2cascadefemalegonadmorphogenesisformationofanatomicalboundarygastrulationwithmouthformingsecondinuteroembryonicdevelopmentinterleukin-6-mediatedsignalingpathwayintracellularsignaltransductionleftventricularcardiacmuscletissuemorphogenesismesendodermdevelopmentmetanephricmesenchymemorphogenesisnegativeregulationofcardiacmusclehypertrophynegativeregulationofcardiacmyofibrilassemblynegativeregulationofcelldeathnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofERK1andERK2cascadenegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednephrogenicmesenchymemorphogenesisneuralcrestcelldifferentiationneuronfatecommitmentosteoblastdifferentiationoutflowtractseptummorphogenesisovarianfollicledevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcellproliferationinvolvedinheartvalvemorphogenesispositiveregulationofepithelialtomesenchymaltransitionpositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofhistoneH3-K4methylationpositiveregulationofhistoneH3-K9acetylationpositiveregulationofluteinizinghormonesecretionpositiveregulationofmiRNAtranscriptionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimuluspositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationofbindingregulationofhairfollicledevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetotransforminggrowthfactorbetasebaceousglanddevelopmentsecondarypalatedevelopmentseminiferoustubuledevelopmentsinglefertilizationSMADproteincomplexassemblySMADproteinsignaltransductionsomiterostral/caudalaxisspecificationspermatogenesistranscriptionbyRNApolymeraseIItranscriptionDNA-templatedtransforminggrowthfactorbetareceptorsignalingpathwayuterusdevelopmentventricularseptummorphogenesiswoundhealing
Growth factor receptor-bound protein 7
526
Growth factor receptor-bound protein 7
526
7.9
79
0.16
GRB7GRB7Q14451Q14451epidermalgrowthfactorreceptorsignalingpathwaynegativeregulationoftranslationpositiveregulationofcellmigrationstressgranuleassembly
F-box-like/WD repeat-containing protein TBL1XR1
330
F-box-like/WD repeat-containing protein TBL1XR1
434
8.7
77
0.15
TBL1RTBL1RQ8BHJ5Q8BHJ5adiposetissuedevelopmentblastocysthatchingchromatinorganizationfatpaddevelopmenthistonedeacetylationlipidcatabolicprocessmulticellularorganismgrowthnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedproteasome-mediatedubiquitin-dependentproteincatabolicprocessregulationofgeneexpressionregulationoftranscriptionbyRNApolymeraseIIregulationoftriglyceridemetabolicprocessresponsetodietaryexcesswhitefatcelldifferentiation
RNA demethylase ALKBH5
200
RNA demethylase ALKBH5
200
7.2
73
0.19
ALKB5ALKB5Q6P6C2Q6P6C2celldifferentiationmRNAexportfromnucleusmRNAprocessingoxidativesingle-strandedRNAdemethylationregulationofmRNAstabilityresponsetohypoxiaspermatogenesis
Gremlin-1
141
Gremlin-1
122
6.8
83
0.18
GREM1GREM1O60565O60565animalorganmorphogenesisapoptoticprocesscardiacmusclecelldifferentiationcardiacmusclecellmyoblastdifferentiationcellmigrationinvolvedinsproutingangiogenesiscellmorphogenesiscell-cellsignalingcollagenfibrilorganizationdeterminationofdorsalidentityembryoniclimbmorphogenesislimbdevelopmentmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesisnegativeregulationofapoptoticprocessnegativeregulationofBMPsignalingpathwaynegativeregulationofbonemineralizationnegativeregulationofbonemineralizationinvolvedinbonematurationnegativeregulationofboneremodelingnegativeregulationofbonetrabeculaformationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellgrowthnegativeregulationofchondrocytedifferentiationnegativeregulationofmonocytechemotaxisnegativeregulationofosteoblastdifferentiationnegativeregulationofosteoblastproliferationnegativeregulationofosteoclastproliferationnegativeregulationofpathway-restrictedSMADproteinphosphorylationnegativeregulationoftranscriptionDNA-templatedpositiveregulationofangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcellpopulationproliferationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofreceptorinternalizationpositiveregulationofsignalingreceptoractivitypositiveregulationoftelomeraseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIproximal/distalpatternformationregulationofepithelialtomesenchymaltransitionregulationoffocaladhesionassemblysequesteringofBMPfromreceptorviaBMPbindingsignaltransductionuretericbudformation
Prosaposin
445
Prosaposin
484
8.7
76
0.15
SAPSAPQ61207Q61207adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayantigenprocessingandpresentationcellularresponsetoorganicsubstanceceramidemetabolicprocesscerebellarPurkinjecelldifferentiationcochleadevelopmentcorneocytedevelopmentcornifiedenvelopeassemblydevelopmentalgrowthepithelialcelldifferentiationinvolvedinprostateglanddevelopmentgalactosylceramidecatabolicprocessgangliosideGM1transporttomembranegeneexpressionglucosylceramidemetabolicprocessglycolipidmetabolicprocessinclusionbodyassemblyintracellularproteintransportlysosomalproteincatabolicprocesslysosomaltransportmembranelipidmetabolicprocessmicturitionmyelinationnegativeregulationofhydrogenperoxide-inducedcelldeathnervoussystemprocessneuromuscularprocesscontrollingbalanceNKTcelldifferentiationpositiveregulationofbeta-galactosidaseactivitypositiveregulationofhydrolaseactivitypositiveregulationofMAPKcascadeprostateglandgrowthproteinsecretionregulationoflipidmetabolicprocessregulationofMAPKcascadesensoryperceptionofsoundsphingolipidmetabolicprocesswalkingbehavior
Serine/threonine-protein kinase MARK1
217
Serine/threonine-protein kinase MARK1
217
8.4
69
0.17
MARK1MARK1Q9P0L2Q9P0L2cytoskeletonorganizationestablishmentofmitochondrionlocalizationintracellularsignaltransductionmicrotubulecytoskeletonorganizationnegativeregulationofepithelialtomesenchymaltransitionnegativeregulationofgeneexpressionneuronmigrationpeptidyl-serinephosphorylationpositiveregulationofgeneexpressionproteinphosphorylationregulationofdendritedevelopmentregulationofneuronprojectiondevelopmentWntsignalingpathway
Glutaredoxin-2, mitochondrial
77
Glutaredoxin-2, mitochondrial
77
6.8
56
0.26
GLRX2GLRX2Q9NS18Q9NS18agingapoptoticprocesscelldifferentiationcellredoxhomeostasiscellularresponsetosuperoxideDNAprotectionglutathionemetabolicprocessregulationofsignaltransductionregulationoftranscriptionDNA-templatedresponsetohydrogenperoxideresponsetoorganicsubstanceresponsetoredoxstateresponsetotemperaturestimulus
Protein polybromo-1
736
Protein polybromo-1
736
8.5
69
0.17
PB1PB1Q86U86Q86U86chromatinremodelingmitoticcellcyclenegativeregulationofcellpopulationproliferationpositiveregulationofcelldifferentiationpositiveregulationofdouble-strandbreakrepairpositiveregulationofmyoblastdifferentiationpositiveregulationofTcelldifferentiationregulationofG0toG1transitionregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofnucleotide-excisionrepairregulationoftranscriptionbyRNApolymeraseII
Glutathione S-transferase Mu 4
78
Glutathione S-transferase Mu 4
78
8.5
78
0.15
GSTM4GSTM4Q03013Q03013glutathionemetabolicprocesslong-chainfattyacidbiosyntheticprocessnitrobenzenemetabolicprocessxenobioticcatabolicprocess
Anionic trypsin-2
64
Amyloid-beta precursor protein
300
8.3
94
0.13
TRY2A4P00763P05067collagencatabolicprocessdigestionproteolysisresponsetonutrientadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Chymotrypsin-like elastase family member 1
72
Elafin
109
7.8
90
0.14
CELA1ELAFP00772P19957proteolysisantibacterialhumoralresponsecopulationinnateimmuneresponsepeptidecross-linking
Transcriptional repressor CTCF
356
Transcriptional repressor CTCF
353
8.5
62
0.19
CTCFCTCFP49711P49711chromatinloopingchromosomesegregationDNAmethylationgenomicimprintingmaintenanceofDNAmethylationnegativeregulationofcellpopulationproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofgeneexpressionpositiveregulationoftranscriptionDNA-templatedproteinlocalizationtochromosomecentromericregionregulationofcentromericsisterchromatidcohesionregulationofgeneexpressionbygenomicimprintingregulationofgeneexpressionepigeneticregulationofhistoneacetylationregulationofhistonemethylationregulationoftranscriptionbyRNApolymeraseII
Inhibitor of nuclear factor kappa-B kinase subunit beta
716
NF-kappa-B essential modulator
76
8.5
65
0.18
IKKBNEMOO14920Q9Y6K9antigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassITAP-dependentcellularresponsetotumornecrosisfactorcorticalactincytoskeletonorganizationFc-epsilonreceptorsignalingpathwayI-kappaBkinase/NF-kappaBsignalinginflammatoryresponseinnateimmuneresponseinterleukin-1-mediatedsignalingpathwaynegativeregulationofbicellulartightjunctionassemblynegativeregulationofmyosin-light-chain-phosphataseactivitypeptidyl-serinephosphorylationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedproteinlocalizationtoplasmamembraneproteinphosphorylationregulationofestablishmentofendothelialbarrierregulationofphosphorylationregulationoftumornecrosisfactor-mediatedsignalingpathwayresponsetovirusstimulatoryC-typelectinreceptorsignalingpathwaystress-activatedMAPKcascadeTcellreceptorsignalingpathwaytumornecrosisfactor-mediatedsignalingpathwayanoikisapoptoticprocesscellularresponsetoDNAdamagestimulusestablishmentofvesiclelocalizationimmuneresponsenegativeregulationofneurondeathpositiveregulationofmacroautophagypositiveregulationofTcellreceptorsignalingpathwayprotein-containingcomplexassemblyregulationofI-kappaBkinase/NF-kappaBsignaling
Histone-lysine N-methyltransferase 2C
1081
Histone-lysine N-methyltransferase 2C
1060
8.5
69
0.17
KMT2CKMT2CQ8NEZ4Q8NEZ4chromatinorganizationhistoneH3-K4methylationhistoneH3-K4monomethylationpositiveregulationoftranscriptionbyRNApolymeraseII
Microcephalin
776
Microcephalin
776
7.8
85
0.15
MCPH1MCPH1Q8NEM0Q8NEM0bonedevelopmentcerebralcortexdevelopmentestablishmentofmitoticspindleorientationmitoticcellcyclenegativeregulationoftranscriptionbyRNApolymeraseIIneuronalstemcellpopulationmaintenanceproteinlocalizationtocentrosomeregulationofcentrosomecycleregulationofchromosomecondensationregulationofinflammatoryresponseregulationofkinaseactivity
Intersectin-1
1410
Intersectin-1
1410
7.4
73
0.18
ITSN1ITSN1Q9Z0R4Q9Z0R4clathrin-dependentsynapticvesicleendocytosisendocytosisendosomaltransportexocytosisnegativeregulationofneuronapoptoticprocessneuronapoptoticprocesspositiveregulationofcaveolin-mediatedendocytosispositiveregulationofdendriticspinedevelopmentpositiveregulationofgrowthhormonesecretionpositiveregulationofproteinkinaseBsignalingproteinlocalizationproteintransportregulationofmodificationofpostsynapticactincytoskeletonsmallGTPasemediatedsignaltransductionsynapticvesicleendocytosis
Chromodomain-helicase-DNA-binding protein 5
622
Chromodomain-helicase-DNA-binding protein 5
622
7.5
67
0.2
CHD5CHD5Q8TDI0Q8TDI0cerebralcortexneurondifferentiationchromatinremodelinghistoneH3-K27trimethylationhistoneH4acetylationnegativeregulationofcellpopulationproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofsignaltransductionbyp53classmediatorregulationoftranscriptionbyRNApolymeraseIIspermatogenesisexchangeofchromosomalproteins
E3 ubiquitin-protein ligase RNF31
871
E3 ubiquitin-protein ligase RNF31
885
7.3
67
0.2
RNF31RNF31Q96EP0Q96EP0CD40signalingpathwaydefenseresponsetobacteriumnegativeregulationofnecroptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteintargetingtomitochondrionpositiveregulationofxenophagyproteinlinearpolyubiquitinationproteinpolyubiquitinationTcellreceptorsignalingpathway
Zinc finger and BTB domain-containing protein 7A
468
Zinc finger and BTB domain-containing protein 7A
387
7.4
74
0.18
ZBT7AZBT7AO95365O95365Bcelldifferentiationchromatinorganizationchromatinremodelingdouble-strandbreakrepairviaclassicalnonhomologousendjoiningerythrocytematurationfatcelldifferentiationnegativeregulationofandrogenreceptorsignalingpathwaynegativeregulationofNotchsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofNF-kappaBtranscriptionfactoractivityproteinlocalizationtonucleusregulationofalternativemRNAsplicingviaspliceosomeregulationofapoptoticprocessregulationofDNA-bindingtranscriptionfactoractivityregulationofglycolyticprocessregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionregulatoryregionDNAbindingtranscriptionDNA-templated
E3 ubiquitin-protein ligase MIB1
286
E3 ubiquitin-protein ligase MIB1
286
7.3
84
0.16
MIB1MIB1Q86YT6Q86YT6bloodvesseldevelopmentendocytosisheartloopinginuteroembryonicdevelopmentnegativeregulationofneurondifferentiationneuraltubeformationneurondifferentiationNotchsignalingpathwaypositiveregulationofendocytosisproteinubiquitinationsomitogenesisubiquitin-dependentproteincatabolicprocess
Choline-phosphate cytidylyltransferase A
139
Choline-phosphate cytidylyltransferase A
139
8.7
109
0.11
PCY1APCY1AP19836P19836CDP-cholinepathwayphosphatidylcholinebiosyntheticprocess
DNA-binding protein SMUBP-2
258
DNA-binding protein SMUBP-2
191
8.7
47
0.24
SMBP2SMBP2P38935P38935DNAduplexunwindingRNAsecondarystructureunwinding
E3 ubiquitin-protein ligase RNF8
456
E3 ubiquitin-protein ligase RNF8
456
7.4
75
0.18
RNF8RNF8O76064O76064cellcyclecelldivisioncellularresponsetoDNAdamagestimulusdouble-strandbreakrepairdouble-strandbreakrepairvianonhomologousendjoininghistoneexchangehistoneH2AK63-linkedubiquitinationhistoneH2AubiquitinationhistoneH2Bubiquitinationinterstrandcross-linkrepairisotypeswitchingnegativeregulationoftranscriptionelongationfromRNApolymeraseIIpromoterpositiveregulationofDNArepairproteinautoubiquitinationproteinK48-linkedubiquitinationproteinK63-linkedubiquitinationproteinubiquitinationresponsetoionizingradiationspermatiddevelopmentspermatogenesisexchangeofchromosomalproteinsubiquitin-dependentproteincatabolicprocess
Gremlin-1
178
Gremlin-1
141
8.9
76
0.15
GREM1GREM1O60565O60565animalorganmorphogenesisapoptoticprocesscardiacmusclecelldifferentiationcardiacmusclecellmyoblastdifferentiationcellmigrationinvolvedinsproutingangiogenesiscellmorphogenesiscell-cellsignalingcollagenfibrilorganizationdeterminationofdorsalidentityembryoniclimbmorphogenesislimbdevelopmentmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesisnegativeregulationofapoptoticprocessnegativeregulationofBMPsignalingpathwaynegativeregulationofbonemineralizationnegativeregulationofbonemineralizationinvolvedinbonematurationnegativeregulationofboneremodelingnegativeregulationofbonetrabeculaformationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellgrowthnegativeregulationofchondrocytedifferentiationnegativeregulationofmonocytechemotaxisnegativeregulationofosteoblastdifferentiationnegativeregulationofosteoblastproliferationnegativeregulationofosteoclastproliferationnegativeregulationofpathway-restrictedSMADproteinphosphorylationnegativeregulationoftranscriptionDNA-templatedpositiveregulationofangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcellpopulationproliferationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofreceptorinternalizationpositiveregulationofsignalingreceptoractivitypositiveregulationoftelomeraseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIproximal/distalpatternformationregulationofepithelialtomesenchymaltransitionregulationoffocaladhesionassemblysequesteringofBMPfromreceptorviaBMPbindingsignaltransductionuretericbudformation
Kelch-like ECH-associated protein 1
434
Kelch-like ECH-associated protein 1
395
6.6
61
0.25
KEAP1KEAP1Q14145Q14145cellularresponsetointerleukin-4cellularresponsetooxidativestresscytoplasmicsequesteringoftranscriptionfactorinuteroembryonicdevelopmentnegativeregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteinubiquitinationregulationofautophagyregulationofepidermalcelldifferentiationubiquitin-dependentproteincatabolicprocess
Suppressor of cytokine signaling 2
167
Elongin-C
112
8.9
nan
nan
SOCS2ELOCO14508P83940cellularresponsetohormonestimulusgrowthhormonereceptorsignalingpathwayintracellularsignaltransductionlactationmammaryglandalveolusdevelopmentnegativeregulationofapoptoticprocessnegativeregulationofmulticellularorganismgrowthnegativeregulationofreceptorsignalingpathwayviaJAK-STATphosphatidylinositolphosphatebiosyntheticprocesspositiveregulationofneurondifferentiationproteinubiquitinationreceptorsignalingpathwayviaJAK-STATregulationofcellgrowthregulationofsignaltransductionresponsetoestradiolpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromotertranscriptioninitiationfromRNApolymeraseIIpromoterubiquitin-dependentproteincatabolicprocess
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
938
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
938
8.2
56
0.22
AT2A1AT2A1P04191P04191calciumionimportintosarcoplasmicreticulumcalciumiontransportnegativeregulationofstriatedmusclecontractionpositiveregulationofATPase-coupledcalciumtransmembranetransporteractivitypositiveregulationofcalciumionimportintosarcoplasmicreticulumpositiveregulationofcardiacmusclecellcontractionpositiveregulationoffast-twitchskeletalmusclefibercontractionregulationofstriatedmusclecontraction
Sequestosome-1
131
Sequestosome-1
131
8.3
56
0.22
SQSTMSQSTMQ13501Q13501aggrephagyapoptoticprocessautophagyautophagyofmitochondrionbrownfatcellproliferationcelldifferentiationendosomaltransportendosomeorganizationenergyhomeostasisimmunesystemprocessintracellularsignaltransductionmacroautophagymitophagynegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofapoptoticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinimportintonucleusproteinlocalizationproteinlocalizationtoperinuclearregionofcytoplasmproteinphosphorylationregulationofI-kappaBkinase/NF-kappaBsignalingregulationofmitochondrionorganizationregulationofproteincomplexstabilityregulationofRasproteinsignaltransductionresponsetoischemiaresponsetomitochondrialdepolarisationselectiveautophagytemperaturehomeostasistranscriptionbyRNApolymeraseIIubiquitin-dependentproteincatabolicprocess
Prothrombin
391
Pancreatic trypsin inhibitor
49
9.6
99
0.11
THRBBPT1P00734P00974acute-phaseresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidebloodcoagulationbloodcoagulationcommonpathwaycellsurfacereceptorsignalingpathwaycytolysisbyhostofsymbiontcellsfibrinolysisnegativeregulationofastrocytedifferentiationnegativeregulationofbloodcoagulationnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationoffibrinolysisnegativeregulationofplateletactivationnegativeregulationofproteolysisneutrophil-mediatedkillingofgram-negativebacteriumplateletactivationpositiveregulationofbloodcoagulationpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationoflipidkinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinphosphorylationpositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofreleaseofsequesteredcalciumionintocytosolproteolysisregulationofbloodcoagulationregulationofcellshaperegulationofcytosoliccalciumionconcentrationresponsetowoundingzymogenactivationnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Tyrosine-protein kinase BTK
481
Baculoviral IAP repeat-containing protein 2
315
6.6
64
0.24
BTKBIRC2Q06187Q13490adaptiveimmuneresponseapoptoticsignalingpathwayBcellactivationBcellaffinitymaturationBcellreceptorsignalingpathwaycalcium-mediatedsignalingcellmaturationcellularresponsetointerleukin-7cellularresponsetomoleculeoffungalorigincellularresponsetoreactiveoxygenspecieseosinophilhomeostasisFc-epsilonreceptorsignalingpathwayhistaminesecretionbymastcellI-kappaBkinase/NF-kappaBsignalinginnateimmuneresponseintracellularsignaltransductionmesodermdevelopmentmonocyteproliferationMyD88-dependenttoll-likereceptorsignalingpathwaynegativeregulationofBcellproliferationnegativeregulationofinterleukin-10productionneutrophilhomeostasispeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofBcelldifferentiationpositiveregulationofBcellproliferationpositiveregulationofimmunoglobulinproductionpositiveregulationofinterleukin-17Aproductionpositiveregulationofinterleukin-6productionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofphagocytosispositiveregulationofsynoviocyteproliferationpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIhypersensitivitypositiveregulationoftypeIIIhypersensitivityproteinphosphorylationproteoglycancatabolicprocessregulationofBcellapoptoticprocessregulationofBcellcytokineproductionresponsetolipopolysaccharidecellsurfacereceptorsignalingpathwaynecroptoticprocessnegativeregulationofapoptoticprocessnegativeregulationofnecroptoticprocessnegativeregulationofripoptosomeassemblyinvolvedinnecroptoticprocessNIK/NF-kappaBsignalingplacentadevelopmentpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofproteinK48-linkedubiquitinationpositiveregulationofproteinK63-linkedubiquitinationpositiveregulationofproteinmonoubiquitinationpositiveregulationofproteinubiquitinationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationregulationofapoptoticprocessregulationofcellcycleregulationofcelldifferentiationregulationofcellpopulationproliferationregulationofcysteine-typeendopeptidaseactivityregulationofinflammatoryresponseregulationofinnateimmuneresponseregulationofnecroptoticprocessregulationofNIK/NF-kappaBsignalingregulationofnucleotide-bindingoligomerizationdomaincontainingsignalingpathwayregulationofreactiveoxygenspeciesmetabolicprocessregulationofRIG-Isignalingpathwayregulationoftoll-likereceptorsignalingpathwayresponsetocAMPresponsetoethanolresponsetohypoxiatumornecrosisfactor-mediatedsignalingpathway
Tubulin polyglutamylase TTLL6
179
Tubulin polyglutamylase TTLL6
259
8.9
66
0.17
TTLL6TTLL6A4Q9E8A4Q9E8microtubulebundleformationmicrotubulecytoskeletonorganizationmicrotubuleseveringpositiveregulationofciliummovementproteinpolyglutamylationregulationofciliumbeatfrequencyinvolvedinciliarymotility
Hemoglobin subunit alpha
104
Hemoglobin subunit beta
112
8.9
89
0.13
HBAHBBP60523P60526
Histone deacetylase 6
1148
Histone deacetylase 6
1148
8.8
78
0.15
HDAC6HDAC6Q9UBN7Q9UBN7aggresomeassemblyautophagyaxonaltransportofmitochondrioncellularresponsetohydrogenperoxidecellularresponsetomisfoldedproteincellularresponsetotopologicallyincorrectproteinciliumassemblyciliumdisassemblycollateralsproutingdendriticspinemorphogenesishistonedeacetylationHsp90deacetylationintracellularproteintransportlysosomelocalizationnegativeregulationofhydrogenperoxidemetabolicprocessnegativeregulationofmicrotubuledepolymerizationnegativeregulationofoxidoreductaseactivitynegativeregulationofprotein-containingcomplexassemblynegativeregulationofprotein-containingcomplexdisassemblynegativeregulationofproteolysisnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedparkin-mediatedstimulationofmitophagyinresponsetomitochondrialdepolarizationpeptidyl-lysinedeacetylationpolyubiquitinatedmisfoldedproteintransportpositiveregulationofepithelialcellmigrationpositiveregulationofhydrogenperoxide-mediatedprogrammedcelldeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsignalingreceptoractivityproteindeacetylationproteindestabilizationproteinpolyubiquitinationproteinqualitycontrolformisfoldedorincompletelysynthesizedproteinsprotein-containingcomplexdisassemblyregulationofandrogenreceptorsignalingpathwayregulationofautophagyregulationofautophagyofmitochondrionregulationofestablishmentofproteinlocalizationregulationoffatcelldifferentiationregulationofgeneexpressionepigeneticregulationofmacroautophagyregulationofmicrotubule-basedmovementregulationofproteinstabilityresponsetogrowthfactorresponsetomisfoldedproteintubulindeacetylationubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathway
Histone deacetylase 8
275
Histone deacetylase 8
275
8.9
73
0.15
HDAC8HDAC8Q9BY41Q9BY41chromatinorganizationhistonedeacetylationnegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIIregulationofcohesinloadingregulationofproteinstabilityregulationoftelomeremaintenanceregulationoftranscriptionbyRNApolymeraseIIsisterchromatidcohesion
Serine/threonine-protein kinase PAK 1
360
Serine/threonine-protein kinase PAK 1
360
6.6
72
0.21
PAK1PAK1Q13153Q13153actincytoskeletonreorganizationapoptoticprocessbranchingmorphogenesisofanepithelialtubecellmigrationcellularresponsetoDNAdamagestimuluschromatinremodelingephrinreceptorsignalingpathwayexocytosisFc-gammareceptorsignalingpathwayinvolvedinphagocytosishepatocytegrowthfactorreceptorsignalingpathwayintracellularsignaltransductionnegativeregulationofcellproliferationinvolvedincontactinhibitionneuronprojectionmorphogenesisphosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofJUNkinaseactivitypositiveregulationofmicrotubulenucleationpositiveregulationofmicrotubulepolymerizationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofstressfiberassemblyproteinautophosphorylationproteinphosphorylationregulationofactincytoskeletonorganizationregulationofaxonogenesisregulationofMAPKcascadestimulatoryC-typelectinreceptorsignalingpathwaywoundhealing
Prosaposin
241
Prosaposin
241
8.9
68
0.16
SAPSAPP07602P07602adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayepithelialcelldifferentiationinvolvedinprostateglanddevelopmentgangliosideGM1transporttomembranelysosomaltransportpositiveregulationofbeta-galactosidaseactivityprostateglandgrowthregulationofautophagyregulationoflipidmetabolicprocesssphingolipidmetabolicprocess
Zinc finger MYND domain-containing protein 11
535
Zinc finger MYND domain-containing protein 11
528
9.6
47
0.22
ZMY11ZMY11Q15326Q15326cellcyclechromatinorganizationdefenseresponsetovirusnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofJNKcascadenegativeregulationoftranscriptionDNA-templatedregulationofsignaltransductionregulationoftranscriptionelongationfromRNApolymeraseIIpromoter
Histone H3.3C
110
Histone H3.3C
110
6.4
84
0.19
H3CH3CQ6NXT2Q6NXT2positiveregulationofcellgrowth
Gamma-interferon-inducible lysosomal thiol reductase
145
Gamma-interferon-inducible lysosomal thiol reductase
159
8.8
77
0.15
GILTGILTQ9ESY9Q9ESY9antigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIInegativeregulationoffibroblastproliferationproteinstabilization
Protein disulfide-isomerase
400
Microsomal triglyceride transfer protein large subunit
866
8.9
69
0.16
PDIA1MTPP07237P55157cellularresponsetohypoxiacellularresponsetointerleukin-7interleukin-12-mediatedsignalingpathwayinterleukin-23-mediatedsignalingpathwaypeptidyl-prolinehydroxylationto4-hydroxy-L-prolinepositiveregulationofcelladhesionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofviralentryintohostcellproteinfoldingproteinfoldinginendoplasmicreticulumregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwayresponsetoendoplasmicreticulumstresscholesterolhomeostasischylomicronassemblycircadianrhythmestablishmentoflocalizationincelllipidmetabolicprocesslipoproteinmetabolicprocesslipoproteintransportlow-densitylipoproteinparticleremodelingphospholipidtransportplasmalipoproteinparticleassemblyproteinlipidationproteinsecretionresponsetocalciumiontriglyceridemetabolicprocesstriglyceridetransportvery-low-densitylipoproteinparticleassembly
DNA (cytosine-5)-methyltransferase 3A
540
DNA (cytosine-5)-methyltransferase 3A
514
6.4
89
0.18
DNM3ADNM3AQ9Y6K1Q9Y6K1agingC-5methylationofcytosinecellularresponsetoaminoacidstimuluscellularresponsetobisphenolAcellularresponsetoethanolcellularresponsetohypoxiaDNAmethylationDNAmethylationinvolvedinembryodevelopmentDNAmethylationinvolvedingametegenerationDNAmethylationoncytosineDNAmethylation-dependentheterochromatinassemblyhepatocyteapoptoticprocessmitoticcellcyclenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneurondifferentiationpositiveregulationofcelldeathregulationofgeneexpressionbygenomicimprintingresponsetococaineresponsetoestradiolresponsetoionizingradiationresponsetoleadionresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulusspermatogenesis
NKG2-D type II integral membrane protein
121
NKG2-D type II integral membrane protein
121
6.6
89
0.17
NKG2DNKG2DO54709O54709adaptiveimmuneresponsecelldifferentiationcellularresponsetolipopolysaccharidedefenseresponsetoGram-positivebacteriumnaturalkillercellactivationnaturalkillercellmediatedcytotoxicitynegativeregulationofGTPaseactivitynegativeregulationofnaturalkillercellchemotaxisnitricoxidebiosyntheticprocesspositiveregulationofapoptoticprocesspositiveregulationofinterferon-gammaproductionpositiveregulationofmyeloiddendriticcellactivationpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationofnitricoxidebiosyntheticprocessstimulatoryC-typelectinreceptorsignalingpathway
Albumin
125
Albumin
538
9.6
70
0.15
ALBUALBUP02768P02768cellularresponsetostarvationmaintenanceofmitochondrionlocationnegativeregulationofapoptoticprocessnegativeregulationofprogrammedcelldeathretinahomeostasis
Hepatocyte growth factor activator
432
Kunitz-type protease inhibitor 1
259
8.9
99
0.11
HGFASPIT1Q04756O43278bloodcoagulationproteolysiszymogenactivationbranchinginvolvedinlabyrinthinelayermorphogenesiscellularresponsetoBMPstimulusepidermisdevelopmentepitheliumdevelopmentextracellularmatrixorganizationnegativeregulationofneuralprecursorcellproliferationneuraltubeclosureplacentabloodvesseldevelopmentpositiveregulationofglialcelldifferentiation
Chymotrypsin-like elastase family member 1
56
Elafin
83
8.2
96
0.13
CELA1ELAFP00772P19957proteolysisantibacterialhumoralresponsecopulationinnateimmuneresponsepeptidecross-linking
Fragile X messenger ribonucleoprotein 1
78
Fragile X messenger ribonucleoprotein 1
99
9.5
70
0.15
FMR1FMR1Q06787Q06787cellularresponsetovirusDNArepairgenesilencingbyRNAglutamatereceptorsignalingpathwaymodulationbyhostofviralRNAgenomereplicationmRNAprocessingmRNAtransportnegativeregulationofcytoplasmictranslationnegativeregulationoflong-termsynapticdepressionnegativeregulationofmRNAcatabolicprocessnegativeregulationofsynapticvesicleexocytosisnegativeregulationoftranslationnegativeregulationoftranslationalinitiationnegativeregulationofvoltage-gatedcalciumchannelactivitynervoussystemdevelopmentpositiveregulationofdendriticspinedevelopmentpositiveregulationoffilopodiumassemblypositiveregulationofintracellulartransportofviralmaterialpositiveregulationofmiRNA-mediatedgenesilencingpositiveregulationofmRNAbindingpositiveregulationofproteasomalproteincatabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofreceptorinternalizationpositiveregulationofresponsetoDNAdamagestimuluspositiveregulationoftranslationregulationofalternativemRNAsplicingviaspliceosomeregulationofdendriticspinedevelopmentregulationoffilopodiumassemblyregulationofmiRNA-mediatedgenesilencingregulationofmRNAstabilityregulationofneuronalactionpotentialregulationofneurotransmittersecretionRNAsplicing
Glandular kallikrein
49
Pancreatic trypsin inhibitor
49
8.8
94
0.12
KLKBPT1P00752P00974regulationofsystemicarterialbloodpressurezymogenactivationnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Complement C5
704
Complement C5
732
9.6
75
0.14
CO5CO5P01031P01031cellsurfacereceptorsignalingpathwaychemotaxiscomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisGprotein-coupledreceptorsignalingpathwayinuteroembryonicdevelopmentinflammatoryresponsenegativeregulationofmacrophagechemotaxispositiveregulationofangiogenesispositiveregulationofchemokineproductionpositiveregulationofimmuneresponsepositiveregulationofvascularendothelialgrowthfactorproduction
Hemoglobin subunit alpha
111
Hemoglobin subunit beta
112
8.9
81
0.14
HBAHBBP60523P60526
Fatty acid synthase
2292
Fatty acid synthase
2292
8.9
71
0.16
FASFASP49327P49327cellularresponsetointerleukin-4establishmentofendothelialintestinalbarrieretherlipidbiosyntheticprocessfattyacidbiosyntheticprocessfattyacidmetabolicprocessglandularepithelialcelldevelopmentinflammatoryresponsemammaryglanddevelopmentmonocytedifferentiationneutrophildifferentiationosteoblastdifferentiation
Dopamine beta-hydroxylase
530
Dopamine beta-hydroxylase
530
8.2
37
0.33
DOPODOPOP09172P09172behavioralresponsetoethanolbloodvesselremodelingchemicalsynaptictransmissiondopaminecatabolicprocessfearresponseglucosehomeostasishomoiothermyleukocytemediatedimmunityleukocytemigrationlocomotorybehaviormaternalbehaviormemorynorepinephrinebiosyntheticprocessoctopaminebiosyntheticprocesspositiveregulationofcold-inducedthermogenesispositiveregulationofvasoconstrictionregulationofextrinsicapoptoticsignalingpathwayregulationofvascularassociatedsmoothmusclecellproliferationregulationofvascularendothelialcellproliferationresponsetoamphetamineresponsetopainvasoconstrictionvisuallearning
MHC class II HLA-DQ-alpha chain
11
HLA class II histocompatibility antigen, DQ beta 1 chain
111
6.3
91
0.17
Q30066Q5SU54Q30066Q5SU54adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Serine/threonine-protein kinase MRCK beta
36
Serine/threonine-protein kinase MRCK beta
41
8.3
69
0.17
MRCKBMRCKBQ9Y5S2Q9Y5S2actincytoskeletonreorganizationactomyosinstructureorganizationcellmigrationcytoskeletonorganizationestablishmentormaintenanceofcellpolaritypeptidyl-threoninephosphorylationproteinphosphorylationsignaltransduction
GMP synthase [glutamine-hydrolyzing]
523
GMP synthase [glutamine-hydrolyzing]
523
8.9
68
0.17
GUAAGUAAP49915P49915glutaminemetabolicprocessGMPbiosyntheticprocesspurinenucleobasebiosyntheticprocesspurineribonucleosidemonophosphatebiosyntheticprocess
Pulmonary surfactant-associated protein B
321
Pulmonary surfactant-associated protein B
321
8.3
76
0.16
PSPBPSPBP50405P50405respiratorygaseousexchangebyrespiratorysystemsphingolipidmetabolicprocess
Glandular kallikrein
33
Pancreatic trypsin inhibitor
49
9.5
102
0.1
KLKBPT1P00752P00974regulationofsystemicarterialbloodpressurezymogenactivationnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Vascular endothelial growth factor A
77
Vascular endothelial growth factor A
94
8.9
67
0.17
VEGFAVEGFAQ96NW5Q96NW5activationofproteinkinaseactivityangiogenesisarterymorphogenesisbasophilchemotaxisbranchinginvolvedinbloodvesselmorphogenesiscamera-typeeyemorphogenesiscardiacmusclecelldevelopmentcardiacvascularsmoothmusclecelldevelopmentcellmaturationcellmigrationinvolvedinsproutingangiogenesiscellularresponsetohypoxiacellularresponsetovascularendothelialgrowthfactorstimuluscellularstressresponsetoacidchemicalcommissuralneuronaxonguidancecoronaryarterymorphogenesiscoronaryveinmorphogenesisdopaminergicneurondifferentiationendothelialcellchemotaxisepithelialcelldifferentiationeyephotoreceptorcelldevelopmentheartmorphogenesisinuteroembryonicdevelopmentinductionofpositivechemotaxiskidneydevelopmentlactationlungdevelopmentlymphvesselmorphogenesismacrophagedifferentiationmammaryglandalveolusdevelopmentmesodermdevelopmentmonocytedifferentiationmotorneuronmigrationnegativeregulationofadherensjunctionorganizationnegativeregulationofapoptoticprocessnegativeregulationofblood-brainbarrierpermeabilitynegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofestablishmentofendothelialbarriernegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentoutflowtractmorphogenesisovarianfollicledevelopmentpositivechemotaxispositiveregulationofangiogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelladhesionpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellmigrationbyvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofcellproliferationbyVEGF-activatedplateletderivedgrowthfactorreceptorsignalingpathwaypositiveregulationofcold-inducedthermogenesispositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialtubeformationpositiveregulationofERK1andERK2cascadepositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofhistonedeacetylaseactivitypositiveregulationofleukocytemigrationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmastcellchemotaxispositiveregulationofneuroblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofpositivechemotaxispositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinkinaseCsignalingpositiveregulationofproteinkinaseDsignalingpositiveregulationofproteinlocalizationtoearlyendosomepositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorinternalizationpositiveregulationofretinalganglioncellaxonguidancepositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftrophoblastcellmigrationpositiveregulationofvascularpermeabilitypost-embryoniccamera-typeeyedevelopmentprimitiveerythrocytedifferentiationregulationofcellshaperegulationofnitricoxidemediatedsignaltransductionregulationofretinalganglioncellaxonguidanceregulationoftranscriptionbyRNApolymeraseIIresponsetohypoxiasproutingangiogenesissurfactanthomeostasistubeformationvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorreceptor-2signalingpathwayvascularendothelialgrowthfactorsignalingpathwayvascularwoundhealingvasculogenesisVEGF-activatedneuropilinsignalingpathway
Pancreatic secretory granule membrane major glycoprotein GP2
146
Pancreatic secretory granule membrane major glycoprotein GP2
172
6.7
71
0.21
GP2GP2P55259P55259antigentranscytosisbyMcellsinmucosal-associatedlymphoidtissueinnateimmuneresponseneutrophilmigration
Crk-like protein
249
Crk-like protein
249
6.3
37
0.43
CRKLCRKLP46109P46109acetylcholinereceptorsignalingpathwayactivationofGTPaseactivityanterior/posteriorpatternspecificationBcellapoptoticprocessbloodvesseldevelopmentcellchemotaxiscellmigrationcellularresponsetointerleukin-7cellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetoxenobioticstimuluscerebellarneurondevelopmentcerebralcortexdevelopmentcranialskeletalsystemdevelopmentdendritedevelopmentendothelinreceptorsignalingpathwayestablishmentofcellpolarityfibroblastgrowthfactorreceptorsignalingpathwayhelperTcelldiapedesishippocampusdevelopmentintracellularsignaltransductionJNKcascadelipidmetabolicprocessmalegonaddevelopmentnegativeregulationofgeneexpressionnegativeregulationofproteinphosphorylationneuronmigrationoutflowtractmorphogenesisparathyroidglanddevelopmentpharynxdevelopmentpositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofglialcellmigrationpositiveregulationofproteinphosphorylationpositiveregulationofsubstrateadhesion-dependentcellspreadingRasproteinsignaltransductionreelin-mediatedsignalingpathwayregulationofcelladhesionmediatedbyintegrinregulationofcellgrowthregulationofdendritedevelopmentregulationofskeletalmuscleacetylcholine-gatedchannelclusteringregulationofTcellmigrationretinoicacidreceptorsignalingpathwaysignaltransductionsinglefertilizationspermatogenesissynapseassemblyTcellreceptorsignalingpathwaythymusdevelopmenturogenitalsystemdevelopment
Retinoblastoma-like protein 1
846
EP300-interacting inhibitor of differentiation 1
180
9.6
73
0.14
RBL1EID1P28749Q9Y6B2cellcyclecelldifferentiationchromatinorganizationnegativeregulationofcellularsenescencenegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIIregulationofcelldivisionregulationoflipidkinaseactivitynegativeregulationoftranscriptionDNA-templatedregulationofcelldifferentiation
Interferon alpha/beta receptor 2
207
Interferon alpha/beta receptor 2
227
8.9
78
0.14
INAR2INAR2P48551P48551cellsurfacereceptorsignalingpathwaycellularresponsetoviruscytokine-mediatedsignalingpathwaydefenseresponsetovirusreceptorsignalingpathwayviaJAK-STATresponsetointerferon-alpharesponsetointerferon-betaresponsetovirustypeIinterferonsignalingpathway
Mineralocorticoid receptor
658
Mineralocorticoid receptor
645
9.5
67
0.16
MCRMCRP08235P08235intracellularsteroidhormonereceptorsignalingpathwaypositiveregulationofNIK/NF-kappaBsignalingregulationoftranscriptionbyRNApolymeraseIIsignaltransduction
Lymphokine-activated killer T-cell-originated protein kinase
70
Lymphokine-activated killer T-cell-originated protein kinase
70
8.3
42
0.29
TOPKTOPKQ96KB5Q96KB5cellularresponsetoUVmitoticcellcyclenegativeregulationofinflammatoryresponsenegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofproteinphosphorylationnegativeregulationofstress-activatedMAPKcascadep38MAPKcascadepeptidyl-serinephosphorylationpositiveregulationofmitoticDNAdamagecheckpointproteasome-mediatedubiquitin-dependentproteincatabolicprocess
Androgen receptor
584
Androgen receptor
584
6.7
68
0.22
ANDRANDRP15207P15207activationofprostateinductionbyandrogenreceptorsignalingpathwayandrogenreceptorsignalingpathwayanimalorganformationcellularresponsetoestrogenstimuluscellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetosteroidhormonestimuluscellularresponsetotestosteronestimuluscopulationepithelialcelldifferentiationinvolvedinprostateglanddevelopmentepithelialcellmorphogenesisfertilizationinuteroembryonicdevelopmentintracellularestrogenreceptorsignalingpathwayintracellularreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaylateralsproutinginvolvedinmammaryglandductmorphogenesisLeydigcelldifferentiationmalecourtshipbehaviormalegenitaliamorphogenesismalegonaddevelopmentmalesexdifferentiationmalesomaticsexdeterminationmammaryglandalveolusdevelopmentmorphogenesisofanepithelialfoldmulticellularorganismgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofepithelialcellproliferationnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofintegrinbiosyntheticprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellproliferationinvolvedinprostateglanddevelopmentpositiveregulationofgeneexpressionpositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofintegrinbiosyntheticprocesspositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpenileerectionpositiveregulationofphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIpositiveregulationoftranscriptionDNA-templatedprostateglandepitheliummorphogenesisprostateglandgrowthregulationofdevelopmentalgrowthregulationofgeneexpressionregulationofprostaticbudformationregulationofproteinlocalizationtoplasmamembraneregulationofsystemicarterialbloodpressureregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedreproductivebehaviorreproductivestructuredevelopmentreproductivesystemdevelopmentresponsetoestradiolresponsetoinsulinresponsetotestosteroneseminiferoustubuledevelopmentsinglefertilizationskeletalmusclehypertrophyspermatogenesistertiarybranchinginvolvedinmammaryglandductmorphogenesis
Transforming growth factor beta-3 proprotein
377
Transforming growth factor beta-3 proprotein
344
8.9
92
0.12
TGFB3TGFB3P10600P10600agingBMPsignalingpathwaycell-celljunctionorganizationdetectionofhypoxiadigestivetractdevelopmentembryonicneurocraniummorphogenesisfacemorphogenesisfemalepregnancyfrontalsuturemorphogenesisinuteroembryonicdevelopmentinnereardevelopmentlungalveolusdevelopmentmammaryglanddevelopmentnegativeregulationofcellpopulationproliferationnegativeregulationofmacrophagecytokineproductionnegativeregulationofneuronapoptoticprocessnegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofvascularassociatedsmoothmusclecellproliferationodontogenesisossificationinvolvedinboneremodelingpositiveregulationofapoptoticprocesspositiveregulationofbonemineralizationpositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationoffilopodiumassemblypositiveregulationofMAPKcascadepositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofSMADproteinsignaltransductionpositiveregulationofstressfiberassemblypositiveregulationoftightjunctiondisassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofcellpopulationproliferationresponsetoestrogenresponsetohypoxiaresponsetolaminarfluidshearstressresponsetoprogesteronesalivaryglandmorphogenesissecondarypalatedevelopmentSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwayuterinewallbreakdownwoundhealing
Vascular endothelial growth factor A
52
Vascular endothelial growth factor A
77
9.6
77
0.14
VEGFAVEGFAQ96NW5Q96NW5activationofproteinkinaseactivityangiogenesisarterymorphogenesisbasophilchemotaxisbranchinginvolvedinbloodvesselmorphogenesiscamera-typeeyemorphogenesiscardiacmusclecelldevelopmentcardiacvascularsmoothmusclecelldevelopmentcellmaturationcellmigrationinvolvedinsproutingangiogenesiscellularresponsetohypoxiacellularresponsetovascularendothelialgrowthfactorstimuluscellularstressresponsetoacidchemicalcommissuralneuronaxonguidancecoronaryarterymorphogenesiscoronaryveinmorphogenesisdopaminergicneurondifferentiationendothelialcellchemotaxisepithelialcelldifferentiationeyephotoreceptorcelldevelopmentheartmorphogenesisinuteroembryonicdevelopmentinductionofpositivechemotaxiskidneydevelopmentlactationlungdevelopmentlymphvesselmorphogenesismacrophagedifferentiationmammaryglandalveolusdevelopmentmesodermdevelopmentmonocytedifferentiationmotorneuronmigrationnegativeregulationofadherensjunctionorganizationnegativeregulationofapoptoticprocessnegativeregulationofblood-brainbarrierpermeabilitynegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofestablishmentofendothelialbarriernegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentoutflowtractmorphogenesisovarianfollicledevelopmentpositivechemotaxispositiveregulationofangiogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelladhesionpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellmigrationbyvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofcellproliferationbyVEGF-activatedplateletderivedgrowthfactorreceptorsignalingpathwaypositiveregulationofcold-inducedthermogenesispositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialtubeformationpositiveregulationofERK1andERK2cascadepositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofhistonedeacetylaseactivitypositiveregulationofleukocytemigrationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmastcellchemotaxispositiveregulationofneuroblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofpositivechemotaxispositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinkinaseCsignalingpositiveregulationofproteinkinaseDsignalingpositiveregulationofproteinlocalizationtoearlyendosomepositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorinternalizationpositiveregulationofretinalganglioncellaxonguidancepositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftrophoblastcellmigrationpositiveregulationofvascularpermeabilitypost-embryoniccamera-typeeyedevelopmentprimitiveerythrocytedifferentiationregulationofcellshaperegulationofnitricoxidemediatedsignaltransductionregulationofretinalganglioncellaxonguidanceregulationoftranscriptionbyRNApolymeraseIIresponsetohypoxiasproutingangiogenesissurfactanthomeostasistubeformationvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorreceptor-2signalingpathwayvascularendothelialgrowthfactorsignalingpathwayvascularwoundhealingvasculogenesisVEGF-activatedneuropilinsignalingpathway
Pulmonary surfactant-associated protein B
298
Pulmonary surfactant-associated protein B
356
8.9
72
0.16
PSPBPSPBP50405P50405respiratorygaseousexchangebyrespiratorysystemsphingolipidmetabolicprocess
Acyloxyacyl hydrolase
114
Acyloxyacyl hydrolase
453
9.6
64
0.16
AOAHAOAHP28039P28039fattyacidmetabolicprocesslipopolysaccharidecatabolicprocessnegativeregulationofinflammatoryresponse
Inositol-trisphosphate 3-kinase A
340
Inositol-trisphosphate 3-kinase A
340
8.9
60
0.19
IP3KAIP3KAP17105P17105actincytoskeletonorganizationcellularresponsetocalciumiondendriticspinemaintenanceinositolmetabolicprocessinositolphosphatebiosyntheticprocessphosphatidylinositolphosphatebiosyntheticprocessphosphorylationpositiveregulationofdendriticspinemorphogenesisregulationofsynapticplasticityresponsetocalciumion
Collagen alpha-1(II) chain
69
Collagen alpha-1(II) chain
86
9.6
54
0.19
CO2A1CO2A1P02458P02458anteriorheaddevelopmentcartilagecondensationcartilagedevelopmentcartilagedevelopmentinvolvedinendochondralbonemorphogenesiscellularresponsetoBMPstimuluscentralnervoussystemdevelopmentchondrocytedifferentiationcollagenfibrilorganizationembryonicskeletaljointmorphogenesisendochondralossificationextracellularmatrixorganizationextrinsicapoptoticsignalingpathwayinabsenceofligandheartmorphogenesisinnerearmorphogenesislimbbudformationnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnotochorddevelopmentoticvesicledevelopmentproteoglycanmetabolicprocessregulationofgeneexpressionroofofmouthdevelopmentsensoryperceptionofsoundskeletalsystemdevelopmenttissuehomeostasisvisualperception
Protein S100-B
85
Protein S100-B
85
8.2
59
0.21
S100BS100BP04271P04271axonogenesiscentralnervoussystemdevelopmentlearningormemorymemorypositiveregulationofcellpopulationproliferationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingregulationofneuronalsynapticplasticity
Histone H3.1
111
Histone H3.1
111
6.2
83
0.19
H31H31P68433P68433DNAreplication-dependentchromatinassemblynucleosomeassemblyregulationofgeneexpressionepigenetic
Regulator of G-protein signaling 3
314
Regulator of G-protein signaling 3
314
6.2
72
0.22
RGS3RGS3P49796P49796Gprotein-coupledreceptorsignalingpathwaynegativeregulationofsignaltransductionregulationofGprotein-coupledreceptorsignalingpathwaysignaltransduction
Platelet basic protein
105
Platelet basic protein
105
8.9
70
0.16
CXCL7CXCL7P02775P02775antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaydefenseresponsetobacteriumglucosetransmembranetransportinflammatoryresponsekillingofcellsofanotherorganismneutrophilchemotaxispositiveregulationofcelldivision
Elongin-C
112
von Hippel-Lindau disease tumor suppressor
162
8.3
nan
nan
ELOCVHLQ2KII4P40337proteinubiquitinationtranscriptioninitiationfromRNApolymeraseIIpromoterubiquitin-dependentproteincatabolicprocesscellmorphogenesisnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationnegativeregulationofgeneexpressionnegativeregulationofreceptorsignalingpathwayviaJAK-STATnegativeregulationoftranscriptionelongationfromRNApolymeraseIIpromoternegativeregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationofcelldifferentiationpositiveregulationoftranscriptionDNA-templatedproteinstabilizationproteolysisregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiaregulationoftranscriptionDNA-templated
cGMP-dependent protein kinase 2
183
cGMP-dependent protein kinase 2
183
6.2
76
0.21
KGP2KGP2Q13237Q13237negativeregulationofchloridetransportnegativeregulationofchondrocyteproliferationpeptidyl-serineautophosphorylationproteinlocalizationtoplasmamembraneproteinphosphorylationregulationofchondrocytedifferentiationsignaltransductiontetrahydrobiopterinmetabolicprocess
Serine/threonine-protein kinase MRCK beta
41
Serine/threonine-protein kinase MRCK beta
41
9.6
68
0.15
MRCKBMRCKBQ9Y5S2Q9Y5S2actincytoskeletonreorganizationactomyosinstructureorganizationcellmigrationcytoskeletonorganizationestablishmentormaintenanceofcellpolaritypeptidyl-threoninephosphorylationproteinphosphorylationsignaltransduction
Mothers against decapentaplegic homolog 2
374
Zinc finger FYVE domain-containing protein 9
783
6.2
82
0.2
SMAD2ZFYV9Q15796O95405activinreceptorsignalingpathwayadrenalglanddevelopmentanatomicalstructuremorphogenesisanterior/posteriorpatternspecificationBMPsignalingpathwaycelldifferentiationcellfatecommitmentcommon-partnerSMADproteinphosphorylationembryoniccranialskeletonmorphogenesisembryonicforegutmorphogenesisendodermformationgastrulationinuteroembryonicdevelopmentinsulinsecretionintracellularsignaltransductionlungdevelopmentmesodermformationnegativeregulationofcellpopulationproliferationnegativeregulationoftranscriptionDNA-templatednodalsignalingpathwayorgangrowthpancreasdevelopmentparaxialmesodermmorphogenesispericardiumdevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofgeneexpressionpositiveregulationofnodalsignalingpathwayinvolvedindeterminationoflateralmesodermleft/rightasymmetrypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpost-embryonicdevelopmentprimarymiRNAprocessingregulationofbindingregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoglucosesecondarypalatedevelopmentsignaltransductioninvolvedinregulationofgeneexpressionSMADproteincomplexassemblySMADproteinsignaltransductiontranscriptionDNA-templatedtransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentwoundhealingzygoticspecificationofdorsal/ventralaxisendocytosisendosomaltransport
Ribonuclease inhibitor
409
Non-secretory ribonuclease
98
9.6
77
0.14
RINIRNAS2P13489P10153mRNAcatabolicprocessregulationofangiogenesischemotaxisdefenseresponsetovirusinnateimmuneresponseinmucosaRNAcatabolicprocessRNAphosphodiesterbondhydrolysis
Receptor-type tyrosine-protein phosphatase C
434
Receptor-type tyrosine-protein phosphatase C
434
8.9
57
0.2
PTPRCPTPRCP08575P08575alpha-betaTcellproliferationBcelldifferentiationBcellproliferationBcellreceptorsignalingpathwaybonemarrowdevelopmentcalcium-mediatedsignalingusingintracellularcalciumsourcecellcyclephasetransitioncellsurfacereceptorsignalingpathwaycellularresponsetoextracellularstimulusdefenseresponsetovirusdephosphorylationDN2thymocytedifferentiationextrinsicapoptoticsignalingpathwaygamma-deltaTcelldifferentiationhematopoieticprogenitorcelldifferentiationheterotypiccell-celladhesionleukocytecell-celladhesionMAPKcascadenaturalkillercelldifferentiationnegativeregulationofcelladhesioninvolvedinsubstrate-boundcellmigrationnegativeregulationofcytokine-mediatedsignalingpathwaynegativeregulationofERK1andERK2cascadenegativeregulationofinterleukin-2productionnegativeregulationofmicroglialcellactivationnegativeregulationofproteinautophosphorylationnegativeregulationofproteinkinaseactivitynegativeregulationofproteintyrosinekinaseactivitynegativeregulationofTcellmediatedcytotoxicitynegativethymicTcellselectionpeptidyl-tyrosinephosphorylationplasmamembraneraftdistributionpositiveregulationofalpha-betaTcellproliferationpositiveregulationofantigenreceptor-mediatedsignalingpathwaypositiveregulationofBcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofFc-gammareceptorsignalingpathwayinvolvedinphagocytosispositiveregulationofgamma-deltaTcelldifferentiationpositiveregulationofhematopoieticstemcellmigrationpositiveregulationofhumoralimmuneresponsemediatedbycirculatingimmunoglobulinpositiveregulationofimmunoglobulinproductionpositiveregulationofinterleukin-2productionpositiveregulationofisotypeswitchingtoIgGisotypespositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseactivitypositiveregulationofproteintyrosinephosphataseactivitypositiveregulationofstemcellproliferationpositiveregulationofTcellmediatedcytotoxicitypositiveregulationofTcellproliferationpositiveregulationoftumornecrosisfactorproductionpositivethymicTcellselectionproteinautophosphorylationproteindephosphorylationregulationofcellcycleregulationofgeneexpressionregulationofinterleukin-8productionregulationofphagocytosisregulationofproteintyrosinekinaseactivityregulationofreceptorsignalingpathwayviaJAK-STATreleaseofsequesteredcalciumionintocytosolresponsetogammaradiationstemcelldevelopmentTcellactivationTcelldifferentiationTcellreceptorsignalingpathway
ADP-ribosylation factor-binding protein GGA1
77
ADP-ribosylation factor-binding protein GGA1
77
6.2
49
0.33
GGA1GGA1Q9UJY5Q9UJY5GolgitoplasmamembraneproteintransportGolgitoplasmamembranetransportintracellularproteintransportpositiveregulationofproteincatabolicprocessproteincatabolicprocessproteinlocalizationproteinlocalizationtocellsurfaceproteinlocalizationtociliarymembraneretrogradetransportendosometoGolgitoxintransport
Cryptochrome-2
381
F-box/LRR-repeat protein 3
340
9.5
82
0.13
CRY2FBXL3Q9R194Q9UKT7circadianregulationofgeneexpressioncircadianrhythmentrainmentofcircadianclockbyphotoperiodglucosehomeostasislipidstoragenegativeregulationofcircadianrhythmnegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofglucocorticoidsecretionnegativeregulationofphosphoproteinphosphataseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedproteinimportintonucleusregulationofcircadianrhythmregulationofsodium-dependentphosphatetransportresponsetoactivityresponsetoinsulinresponsetolightstimulusG2/MtransitionofmitoticcellcycleproteindestabilizationproteinubiquitinationregulationofcellcyclerhythmicprocessSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocess
Histone H3.2
111
Histone H3.2
111
6.2
79
0.2
H32H32Q71DI3Q71DI3nucleosomeassembly
Cytidine deaminase
59
Cytidine deaminase
102
6.1
89
0.19
CDDCDDP56389P56389cellularresponsetoexternalbioticstimulusCMPcatabolicprocesscytidinedeaminationdCMPcatabolicprocessnegativeregulationofcellgrowthnegativeregulationofnucleotidemetabolicprocessresponsetocycloheximideUMPsalvage
Alanine--glyoxylate aminotransferase
106
Alanine--glyoxylate aminotransferase
106
8.3
82
0.15
AGT1AGT1Q8R128Q8R128glycinebiosyntheticprocessbytransaminationofglyoxylateglyoxylatecatabolicprocessglyoxylatemetabolicprocessL-alaninecatabolicprocessL-cysteinecatabolicprocessL-serinemetabolicprocessNotchsignalingpathwayoxalicacidsecretionpyruvatebiosyntheticprocessresponsetocAMPresponsetoglucocorticoid
Nuclear receptor subfamily 1 group I member 3
233
Nuclear receptor subfamily 1 group I member 3
233
9.9
69
0.15
NR1I3NR1I3O35627O35627celldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedosteoblastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templated
Caspase-1
136
Caspase-1
364
9.9
54
0.19
CASP1CASP1P29466P29466apoptoticprocesscellularresponsetointerferon-gammacellularresponsetolipopolysaccharidecellularresponsetomechanicalstimuluscellularresponsetoorganicsubstancecytokineprecursorprocessingdefenseresponsetovirusicosanoidbiosyntheticprocessosmosensorysignalingpathwaypatternrecognitionreceptorsignalingpathwaypositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayproteinautoprocessingproteolysispyroptosisregulationofapoptoticprocessregulationofinflammatoryresponsesignaltransductionsignalingreceptorligandprecursorprocessing
APOBEC3H
85
APOBEC3H
85
6.2
79
0.2
B7TQM6B7TQM6B7TQM6B7TQM6
PHD finger protein 6
215
PHD finger protein 6
283
9.9
80
0.13
PHF6PHF6Q8IWS0Q8IWS0blastocysthatchingnegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Transcription factor IIIB 50 kDa subunit
370
TATA-box-binding protein
262
9.9
54
0.19
BRF2TBPQ9HAW0P20226cellularresponsetooxidativestressDNA-templatedtranscriptioninitiationregulationoftranscriptionbyRNApolymeraseIIItranscriptionpreinitiationcomplexassemblymRNAtranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationfromRNApolymeraseIIpromoterproteinphosphorylationRNApolymeraseIIpreinitiationcomplexassemblytranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseIIItranscriptioninitiationfromRNApolymeraseIIpromoter
Pleckstrin
295
Pleckstrin
250
9.9
78
0.13
PLEKPLEKP08567P08567actincytoskeletonreorganizationcellprojectionorganizationcorticalactincytoskeletonorganizationhematopoieticprogenitorcelldifferentiationintegrin-mediatedsignalingpathwaynegativeregulationofcalcium-mediatedsignalingnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofinositolphosphatebiosyntheticprocessphosphatidylinositolmetabolicprocessphospholipaseC-inhibitingGprotein-coupledreceptorsignalingpathwayplateletaggregationplateletdegranulationpositiveregulationofactinfilamentbundleassemblypositiveregulationofactinfilamentdepolymerizationpositiveregulationofinositol-polyphosphate5-phosphataseactivitypositiveregulationofintegrinactivationpositiveregulationofplateletactivationproteinkinaseCsignalingproteinsecretionbyplateletregulationofcelldiameterruffleorganizationthrombin-activatedreceptorsignalingpathwayvesicledockinginvolvedinexocytosis
Regulator of nonsense transcripts 1
237
Regulator of nonsense transcripts 1
237
8.2
72
0.17
RENT1RENT1Q92900Q92900"3-UTR-mediatedmRNAdestabilization"cellcyclephasetransitioncellularresponsetointerleukin-1cellularresponsetolipopolysaccharideDNAduplexunwindingDNArepairDNAreplicationhistonemRNAcatabolicprocessmRNAexportfromnucleusnuclear-transcribedmRNAcatabolicprocessnuclear-transcribedmRNAcatabolicprocessendonucleolyticcleavage-dependentdecaynuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecaypositiveregulationofmRNAcatabolicprocessregulationoftelomeremaintenanceregulationoftranslationalterminationtelomeremaintenanceviasemi-conservativereplication
C-C motif chemokine 13
58
C-C motif chemokine 13
58
8.8
52
0.22
CCL13CCL13Q99616Q99616antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytoskeletonorganizationeosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivityregulationofcellshapesignaltransduction
Collagen alpha-1(II) chain
86
Collagen alpha-1(II) chain
86
8.8
55
0.21
CO2A1CO2A1P02458P02458anteriorheaddevelopmentcartilagecondensationcartilagedevelopmentcartilagedevelopmentinvolvedinendochondralbonemorphogenesiscellularresponsetoBMPstimuluscentralnervoussystemdevelopmentchondrocytedifferentiationcollagenfibrilorganizationembryonicskeletaljointmorphogenesisendochondralossificationextracellularmatrixorganizationextrinsicapoptoticsignalingpathwayinabsenceofligandheartmorphogenesisinnerearmorphogenesislimbbudformationnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnotochorddevelopmentoticvesicledevelopmentproteoglycanmetabolicprocessregulationofgeneexpressionroofofmouthdevelopmentsensoryperceptionofsoundskeletalsystemdevelopmenttissuehomeostasisvisualperception
MORC family CW-type zinc finger protein 3
416
MORC family CW-type zinc finger protein 3
416
9.9
66
0.15
MORC3MORC3Q14149Q14149innateimmuneresponsemaintenanceofproteinlocationinnucleusnegativeregulationoffibroblastproliferationpeptidyl-serinephosphorylationpositiveregulationofcellularsenescencepost-embryonicdevelopmentproteinphosphorylationproteinstabilization
NKG2-D type II integral membrane protein
121
NKG2-D type II integral membrane protein
115
8.8
81
0.14
NKG2DNKG2DO54709O54709adaptiveimmuneresponsecelldifferentiationcellularresponsetolipopolysaccharidedefenseresponsetoGram-positivebacteriumnaturalkillercellactivationnaturalkillercellmediatedcytotoxicitynegativeregulationofGTPaseactivitynegativeregulationofnaturalkillercellchemotaxisnitricoxidebiosyntheticprocesspositiveregulationofapoptoticprocesspositiveregulationofinterferon-gammaproductionpositiveregulationofmyeloiddendriticcellactivationpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationofnitricoxidebiosyntheticprocessstimulatoryC-typelectinreceptorsignalingpathway
C-C motif chemokine 4
58
C-C motif chemokine 4
34
6.2
71
0.23
CCL4CCL4P13236P13236celladhesioncell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwayeosinophilchemotaxisestablishmentormaintenanceofcellpolarityGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponselymphocytechemotaxismonocytechemotaxisnegativeregulationbyhostofviraltranscriptionneutrophilchemotaxispositiveregulationofcalciumiontransportpositiveregulationofcalcium-mediatedsignalingpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofnaturalkillercellchemotaxisresponsetotoxicsubstanceresponsetovirussignaltransduction
ABO glycosyltransferase
70
ABO glycosyltransferase
70
9.9
70
0.14
Q70V26Q70V26Q70V26Q70V26carbohydratemetabolicprocess
C-type lectin domain family 4 member A
222
C-type lectin domain family 4 member A
203
9.9
100
0.1
CLC4ACLC4AQ9UMR7Q9UMR7adaptiveimmuneresponseantifungalinnateimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassICD8-positivealpha-betaTcellactivationcelladhesioncellsurfacereceptorsignalingpathwayimmuneresponsenegativeregulationofcytokineproductionnegativeregulationoftumornecrosisfactorproductionplasmacytoiddendriticcellantigenprocessingandpresentation
Neurotrophin-3
248
Neurotrophin-3
152
8.8
83
0.14
NTF3NTF3P20783P20783activationofGTPaseactivityactivationofproteinkinaseBactivitycell-cellsignalinginductionofpositivechemotaxismemorymodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnegativeregulationofpeptidyl-tyrosinephosphorylationnervedevelopmentnervegrowthfactorsignalingpathwaynervoussystemdevelopmentneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofactincytoskeletonreorganizationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofreceptorinternalizationregulationofapoptoticprocessregulationofneurondifferentiationsignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
Neurogenic locus notch homolog protein 1
1545
Neurogenic locus notch homolog protein 1
1545
8.8
57
0.2
NOTC1NOTC1P46531P46531animalorganregenerationaorticvalvemorphogenesisapoptoticprocessinvolvedinembryonicdigitmorphogenesisarterialendothelialcelldifferentiationastrocytedifferentiationatrioventricularnodedevelopmentatrioventricularvalvemorphogenesisauditoryreceptorcellfatecommitmentaxonguidancebranchingmorphogenesisofanepithelialtubecalcium-ionregulatedexocytosiscardiacatriummorphogenesiscardiacchamberformationcardiacepithelialtomesenchymaltransitioncardiacleftventriclemorphogenesiscardiacmusclecellmyoblastdifferentiationcardiacmusclecellproliferationcardiacmuscletissuemorphogenesiscardiacrightatriummorphogenesiscardiacrightventricleformationcardiacseptummorphogenesiscardiacvascularsmoothmusclecelldevelopmentcardiacventriclemorphogenesiscelldifferentiationinspinalcordcellmigrationinvolvedinendocardialcushionformationcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetotumorcellcellularresponsetovascularendothelialgrowthfactorstimulusciliumassemblycollectingductdevelopmentcompartmentpatternspecificationcoronaryarterymorphogenesiscoronarysinusvalvemorphogenesiscoronaryveinmorphogenesisdeterminationofleft/rightsymmetrydistaltubuledevelopmentembryonichindlimbmorphogenesisendocardialcelldifferentiationendocardialcushionmorphogenesisendocardiumdevelopmentendocardiummorphogenesisendodermdevelopmentepidermalcellfatespecificationepithelialcellfatecommitmentepithelialcellproliferationepithelialtomesenchymaltransitionepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationforebraindevelopmentforegutmorphogenesisglomerularmesangialcelldevelopmentgrowthinvolvedinheartmorphogenesishairfolliclemorphogenesisheartdevelopmentheartloopinghearttrabeculamorphogenesishomeostasisofnumberofcellswithinatissuehumoralimmuneresponseimmuneresponseinuteroembryonicdevelopmentinflammatoryresponsetoantigenicstimulusinhibitionofneuroepithelialcelldifferentiationinterleukin-17-mediatedsignalingpathwaykeratinocytedifferentiationleft/rightaxisspecificationliverdevelopmentlungdevelopmentmesenchymalcelldevelopmentmitralvalveformationnegativeregulationofanoikisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofBMPsignalingpathwaynegativeregulationofcalciumion-dependentexocytosisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcardiacmusclehypertrophynegativeregulationofcatalyticactivitynegativeregulationofcelladhesionmoleculeproductionnegativeregulationofcellmigrationinvolvedinsproutingangiogenesisnegativeregulationofcellpopulationproliferationnegativeregulationofcellproliferationinvolvedinheartvalvemorphogenesisnegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcell-substrateadhesionnegativeregulationofcold-inducedthermogenesisnegativeregulationofendothelialcellchemotaxisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixconstituentsecretionnegativeregulationofgeneexpressionnegativeregulationofglialcellproliferationnegativeregulationofinnerearauditoryreceptorcelldifferentiationnegativeregulationofmyoblastdifferentiationnegativeregulationofmyotubedifferentiationnegativeregulationofneurogenesisnegativeregulationofoligodendrocytedifferentiationnegativeregulationofossificationnegativeregulationofosteoblastdifferentiationnegativeregulationofphotoreceptorcelldifferentiationnegativeregulationofpro-BcelldifferentiationnegativeregulationofstemcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneuraltubedevelopmentneuroendocrinecelldifferentiationneuronalstemcellpopulationmaintenanceNotchsignalinginvolvedinheartdevelopmentNotchsignalingpathwayNotchsignalingpathwayinvolvedinregulationofsecondaryheartfieldcardioblastproliferationoligodendrocytedifferentiationoutflowtractmorphogenesispericardiummorphogenesispositiveregulationofaortamorphogenesispositiveregulationofapoptoticprocessinvolvedinmorphogenesispositiveregulationofastrocytedifferentiationpositiveregulationofBMPsignalingpathwaypositiveregulationofcardiacepithelialtomesenchymaltransitionpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcelldifferentiationpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofkeratinocytedifferentiationpositiveregulationofneuroblastproliferationpositiveregulationofNotchsignalingpathwaypositiveregulationofRasproteinsignaltransductionpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionofNotchreceptortargetpositiveregulationoftranscriptionDNA-templatedpositiveregulationofviralgenomereplicationprostateglandepitheliummorphogenesisproteincatabolicprocessproteinimportintonucleuspulmonaryvalvemorphogenesisregulationofepithelialcellproliferationinvolvedinprostateglanddevelopmentregulationofextracellularmatrixassemblyregulationofsomitogenesisregulationofstemcellproliferationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetocorticosteroidresponsetolipopolysaccharideresponsetomuramyldipeptideretinalconecelldifferentiationsecretorycolumnalluminarepithelialcelldifferentiationinvolvedinprostateglandularacinusdevelopmentskeletalmusclecelldifferentiationsomaticstemcelldivisionspermatogenesissproutingangiogenesisT-helper17typeimmuneresponsetissueregenerationtranscriptionbyRNApolymeraseIItubeformationvasculogenesisinvolvedincoronaryvascularmorphogenesisvenousendothelialcelldifferentiationventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesis
Histone-lysine N-methyltransferase 2C
1078
Histone-lysine N-methyltransferase 2C
1078
6.1
71
0.23
KMT2CKMT2CQ8NEZ4Q8NEZ4chromatinorganizationhistoneH3-K4methylationhistoneH3-K4monomethylationpositiveregulationoftranscriptionbyRNApolymeraseII
Ubiquitin carboxyl-terminal hydrolase 34
1903
Ubiquitin carboxyl-terminal hydrolase 34
1903
8.5
93
0.13
UBP34UBP34Q70CQ2Q70CQ2positiveregulationofcanonicalWntsignalingpathwayproteindeubiquitinationproteinK48-linkeddeubiquitinationubiquitin-dependentproteincatabolicprocessWntsignalingpathway
Beta-nerve growth factor
136
Beta-nerve growth factor
136
9.9
77
0.13
NGFNGFP01139P01139activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessadultlocomotorybehavioraxonextensioncircadianrhythmextrinsicapoptoticsignalingpathwayinabsenceofligandextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsmemorymodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnegativeregulationoftypeBpancreaticcellapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwayneuronapoptoticprocessneuronprojectiondevelopmentneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofaxonextensionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofcollateralsproutingpositiveregulationofDNAbindingpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofneurondifferentiationpositiveregulationofneuronmaturationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofneurotrophinTRKreceptorsignalingpathwaypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinautophosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinphosphorylationpositiveregulationofproteinubiquitinationpositiveregulationofRasproteinsignaltransductionpositiveregulationofstemcellproliferationproteinphosphorylationregulationofneurondifferentiationregulationofneurotransmittersecretionregulationofreleaseofsequesteredcalciumionintocytosolsensoryperceptionofpaintransmembranereceptorproteintyrosinekinasesignalingpathway
Cytoplasmic FMR1-interacting protein 1
731
Nck-associated protein 1
633
8.8
65
0.17
CYFP1NCKP1Q7L576Q9Y2A7axonextensionaxonguidancecellmorphogenesiscellprojectionassemblycellularresponsetoinsulinstimuluscognitiondendriteextensionlamellipodiumassemblymodificationofsynapticstructurenegativeregulationofsynapticvesiclerecyclingpositiveregulationofArp2/3complex-mediatedactinnucleationpositiveregulationofaxonextensionpositiveregulationofdendritedevelopmentpositiveregulationoflamellipodiumassemblypositiveregulationofneurotrophinTRKreceptorsignalingpathwaypositiveregulationofruffleassemblyRacproteinsignaltransductionregulationofactinfilamentpolymerizationregulationofcellshaperegulationofmodificationofpostsynapticactincytoskeletonregulationofmyelinationregulationoftranslationregulationoftranslationatpostsynapsemodulatingsynaptictransmissionresponsetoelectricalstimulusruffleorganizationapoptoticprocesscellmigrationcentralnervoussystemdevelopmentcorticalactincytoskeletonorganizationneuronprojectionmorphogenesispositiveregulationofactinfilamentpolymerization
Neurogenic locus notch homolog protein 1
1549
Neurogenic locus notch homolog protein 1
1549
8.8
83
0.14
NOTC1NOTC1P46531P46531animalorganregenerationaorticvalvemorphogenesisapoptoticprocessinvolvedinembryonicdigitmorphogenesisarterialendothelialcelldifferentiationastrocytedifferentiationatrioventricularnodedevelopmentatrioventricularvalvemorphogenesisauditoryreceptorcellfatecommitmentaxonguidancebranchingmorphogenesisofanepithelialtubecalcium-ionregulatedexocytosiscardiacatriummorphogenesiscardiacchamberformationcardiacepithelialtomesenchymaltransitioncardiacleftventriclemorphogenesiscardiacmusclecellmyoblastdifferentiationcardiacmusclecellproliferationcardiacmuscletissuemorphogenesiscardiacrightatriummorphogenesiscardiacrightventricleformationcardiacseptummorphogenesiscardiacvascularsmoothmusclecelldevelopmentcardiacventriclemorphogenesiscelldifferentiationinspinalcordcellmigrationinvolvedinendocardialcushionformationcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetotumorcellcellularresponsetovascularendothelialgrowthfactorstimulusciliumassemblycollectingductdevelopmentcompartmentpatternspecificationcoronaryarterymorphogenesiscoronarysinusvalvemorphogenesiscoronaryveinmorphogenesisdeterminationofleft/rightsymmetrydistaltubuledevelopmentembryonichindlimbmorphogenesisendocardialcelldifferentiationendocardialcushionmorphogenesisendocardiumdevelopmentendocardiummorphogenesisendodermdevelopmentepidermalcellfatespecificationepithelialcellfatecommitmentepithelialcellproliferationepithelialtomesenchymaltransitionepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationforebraindevelopmentforegutmorphogenesisglomerularmesangialcelldevelopmentgrowthinvolvedinheartmorphogenesishairfolliclemorphogenesisheartdevelopmentheartloopinghearttrabeculamorphogenesishomeostasisofnumberofcellswithinatissuehumoralimmuneresponseimmuneresponseinuteroembryonicdevelopmentinflammatoryresponsetoantigenicstimulusinhibitionofneuroepithelialcelldifferentiationinterleukin-17-mediatedsignalingpathwaykeratinocytedifferentiationleft/rightaxisspecificationliverdevelopmentlungdevelopmentmesenchymalcelldevelopmentmitralvalveformationnegativeregulationofanoikisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofBMPsignalingpathwaynegativeregulationofcalciumion-dependentexocytosisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcardiacmusclehypertrophynegativeregulationofcatalyticactivitynegativeregulationofcelladhesionmoleculeproductionnegativeregulationofcellmigrationinvolvedinsproutingangiogenesisnegativeregulationofcellpopulationproliferationnegativeregulationofcellproliferationinvolvedinheartvalvemorphogenesisnegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcell-substrateadhesionnegativeregulationofcold-inducedthermogenesisnegativeregulationofendothelialcellchemotaxisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixconstituentsecretionnegativeregulationofgeneexpressionnegativeregulationofglialcellproliferationnegativeregulationofinnerearauditoryreceptorcelldifferentiationnegativeregulationofmyoblastdifferentiationnegativeregulationofmyotubedifferentiationnegativeregulationofneurogenesisnegativeregulationofoligodendrocytedifferentiationnegativeregulationofossificationnegativeregulationofosteoblastdifferentiationnegativeregulationofphotoreceptorcelldifferentiationnegativeregulationofpro-BcelldifferentiationnegativeregulationofstemcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneuraltubedevelopmentneuroendocrinecelldifferentiationneuronalstemcellpopulationmaintenanceNotchsignalinginvolvedinheartdevelopmentNotchsignalingpathwayNotchsignalingpathwayinvolvedinregulationofsecondaryheartfieldcardioblastproliferationoligodendrocytedifferentiationoutflowtractmorphogenesispericardiummorphogenesispositiveregulationofaortamorphogenesispositiveregulationofapoptoticprocessinvolvedinmorphogenesispositiveregulationofastrocytedifferentiationpositiveregulationofBMPsignalingpathwaypositiveregulationofcardiacepithelialtomesenchymaltransitionpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcelldifferentiationpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofkeratinocytedifferentiationpositiveregulationofneuroblastproliferationpositiveregulationofNotchsignalingpathwaypositiveregulationofRasproteinsignaltransductionpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionofNotchreceptortargetpositiveregulationoftranscriptionDNA-templatedpositiveregulationofviralgenomereplicationprostateglandepitheliummorphogenesisproteincatabolicprocessproteinimportintonucleuspulmonaryvalvemorphogenesisregulationofepithelialcellproliferationinvolvedinprostateglanddevelopmentregulationofextracellularmatrixassemblyregulationofsomitogenesisregulationofstemcellproliferationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedresponsetocorticosteroidresponsetolipopolysaccharideresponsetomuramyldipeptideretinalconecelldifferentiationsecretorycolumnalluminarepithelialcelldifferentiationinvolvedinprostateglandularacinusdevelopmentskeletalmusclecelldifferentiationsomaticstemcelldivisionspermatogenesissproutingangiogenesisT-helper17typeimmuneresponsetissueregenerationtranscriptionbyRNApolymeraseIItubeformationvasculogenesisinvolvedincoronaryvascularmorphogenesisvenousendothelialcelldifferentiationventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesis
Prosaposin
509
Prosaposin
484
9.9
67
0.15
SAPSAPQ61207Q61207adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayantigenprocessingandpresentationcellularresponsetoorganicsubstanceceramidemetabolicprocesscerebellarPurkinjecelldifferentiationcochleadevelopmentcorneocytedevelopmentcornifiedenvelopeassemblydevelopmentalgrowthepithelialcelldifferentiationinvolvedinprostateglanddevelopmentgalactosylceramidecatabolicprocessgangliosideGM1transporttomembranegeneexpressionglucosylceramidemetabolicprocessglycolipidmetabolicprocessinclusionbodyassemblyintracellularproteintransportlysosomalproteincatabolicprocesslysosomaltransportmembranelipidmetabolicprocessmicturitionmyelinationnegativeregulationofhydrogenperoxide-inducedcelldeathnervoussystemprocessneuromuscularprocesscontrollingbalanceNKTcelldifferentiationpositiveregulationofbeta-galactosidaseactivitypositiveregulationofhydrolaseactivitypositiveregulationofMAPKcascadeprostateglandgrowthproteinsecretionregulationoflipidmetabolicprocessregulationofMAPKcascadesensoryperceptionofsoundsphingolipidmetabolicprocesswalkingbehavior
Ribonuclease pancreatic
91
Ribonuclease inhibitor
404
9.9
63
0.16
RNAS1RINIP61823P10775defenseresponsetoGram-positivebacteriumRNAphosphodiesterbondhydrolysisregulationofangiogenesis
Histone-lysine N-methyltransferase 2A
1575
Histone-lysine N-methyltransferase 2A
1572
8.9
51
0.22
KMT2AKMT2AQ03164Q03164anterior/posteriorpatternspecificationapoptoticprocesschromatinorganizationcircadianregulationofgeneexpressiondefinitivehemopoiesisDNAmethylationembryonichemopoiesisexplorationbehaviorfibroblastproliferationhistoneH3-K4dimethylationhistoneH3-K4methylationhistoneH3-K4monomethylationhistoneH3-K4trimethylationhistoneH4-K16acetylationhomeostasisofnumberofcellswithinatissuemembranedepolarizationnegativeregulationofDNAmethylationnegativeregulationoffibroblastproliferationpeptidyl-lysinemonomethylationpositiveregulationofhistoneH3-K4methylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransporteractivitypost-embryonicdevelopmentprotein-containingcomplexassemblyregulationofhistoneH3-K14acetylationregulationofhistoneH3-K27acetylationregulationofhistoneH3-K9acetylationregulationofshort-termneuronalsynapticplasticityresponsetopotassiumionspleendevelopmentvisuallearning
Cytidine deaminase
59
Cytidine deaminase
102
6.2
62
0.26
CDDCDDP32320P32320cellsurfacereceptorsignalingpathwaycellularresponsetoexternalbioticstimuluscytidinedeaminationcytosinemetabolicprocessnegativeregulationofcellgrowthnegativeregulationofnucleotidemetabolicprocesspyrimidine-containingcompoundsalvageresponsetocycloheximideUMPsalvage
DNA (cytosine-5)-methyltransferase 3A
559
DNA (cytosine-5)-methyltransferase 3A
520
8.9
69
0.16
DNM3ADNM3AQ9Y6K1Q9Y6K1agingC-5methylationofcytosinecellularresponsetoaminoacidstimuluscellularresponsetobisphenolAcellularresponsetoethanolcellularresponsetohypoxiaDNAmethylationDNAmethylationinvolvedinembryodevelopmentDNAmethylationinvolvedingametegenerationDNAmethylationoncytosineDNAmethylation-dependentheterochromatinassemblyhepatocyteapoptoticprocessmitoticcellcyclenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneurondifferentiationpositiveregulationofcelldeathregulationofgeneexpressionbygenomicimprintingresponsetococaineresponsetoestradiolresponsetoionizingradiationresponsetoleadionresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulusspermatogenesis
Low affinity immunoglobulin epsilon Fc receptor
273
Low affinity immunoglobulin epsilon Fc receptor
273
8.9
85
0.13
FCER2FCER2P06734P06734positiveregulationofhumoralimmuneresponsemediatedbycirculatingimmunoglobulinpositiveregulationofkillingofcellsofanotherorganismpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofnitric-oxidesynthasebiosyntheticprocess
Receptor tyrosine-protein kinase erbB-3
202
Receptor tyrosine-protein kinase erbB-3
202
9.9
67
0.15
ERBB3ERBB3P21860P21860cranialnervedevelopmentendocardialcushiondevelopmentERBB2-ERBB3signalingpathwayextrinsicapoptoticsignalingpathwayinabsenceofligandheartdevelopmentmotorneuronapoptoticprocessnegativeregulationofcelladhesionnegativeregulationofmotorneuronapoptoticprocessnegativeregulationofneuronapoptoticprocessnegativeregulationofsecretionnegativeregulationofsignaltransductionnervoussystemdevelopmentneuronapoptoticprocessperipheralnervoussystemdevelopmentphosphatidylinositol3-kinasesignalingpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcardiacmuscletissuedevelopmentpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofkinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteintyrosinekinaseactivityproteinphosphorylationregulationofcellpopulationproliferationSchwanncelldifferentiationsignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathwaywoundhealing
DNA repair protein XRCC4
165
DNA repair protein XRCC4
165
6.1
62
0.27
XRCC4XRCC4Q13426Q13426DNAligationinvolvedinDNArepairdouble-strandbreakrepairdouble-strandbreakrepairvianonhomologousendjoiningimmunoglobulinV(D)Jrecombinationpositiveregulationofligaseactivitypositiveregulationofphosphatidylserineexposureonapoptoticcellsurfaceproteinlocalizationtositeofdouble-strandbreakresponsetoX-ray
Poly [ADP-ribose] polymerase
970
Poly [ADP-ribose] polymerase
973
8.3
63
0.19
Q59FX0Q59FX0Q59FX0Q59FX0positiveregulationoftelomeremaintenanceviatelomerasespindleassemblyWntsignalingpathway
Glutathione peroxidase 1
98
Glutathione peroxidase 1
98
6.2
85
0.19
GPX1GPX1P00435P00435angiogenesisinvolvedinwoundhealingarachidonicacidmetabolicprocessbiologicalprocessinvolvedininteractionwithsymbiontbloodvesselendothelialcellmigrationcellredoxhomeostasisendothelialcelldevelopmentfatcelldifferentiationfibroblastproliferationglutathionemetabolicprocessheartcontractionhydrogenperoxidecatabolicprocessintrinsicapoptoticsignalingpathwayinresponsetooxidativestresslipoxygenasepathwaymyoblastdifferentiationmyoblastproliferationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofinflammatoryresponsetoantigenicstimulusnegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofreleaseofcytochromecfrommitochondrianeuronapoptoticprocesspositiveregulationofproteinkinaseBsignalingpositiveregulationofsupramolecularfiberorganizationproteinoxidationregulationofgeneexpressionepigeneticregulationofmammaryglandepithelialcellproliferationregulationofproteasomalproteincatabolicprocessresponsetogammaradiationresponsetohydrogenperoxideresponsetohydroperoxideresponsetoseleniumionresponsetosymbioticbacteriumresponsetoxenobioticstimulussensoryperceptionofsoundskeletalmusclefiberdevelopmentskeletalmuscletissueregenerationtemperaturehomeostasistriglyceridemetabolicprocessUVprotectionvasodilation
C-C motif chemokine 2
34
C-C motif chemokine 2
34
6.2
72
0.23
CCL2CCL2P13500P13500angiogenesisanimalorganmorphogenesisastrocytecellmigrationcelladhesioncellsurfacereceptorsignalingpathwaycellularhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetolipopolysaccharidecellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytokine-mediatedsignalingpathwaycytoskeletonorganizationeosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerhelperTcellextravasationhumoralimmuneresponseinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofglialcellapoptoticprocessnegativeregulationofnaturalkillercellchemotaxisnegativeregulationofneuronapoptoticprocessnegativeregulationofvascularendothelialcellproliferationneutrophilchemotaxispositiveregulationofapoptoticcellclearancepositiveregulationofcalciumionimportpositiveregulationofendothelialcellapoptoticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofNMDAglutamatereceptoractivitypositiveregulationofsynaptictransmissionglutamatergicpositiveregulationofTcellactivationproteinkinaseBsignalingproteinphosphorylationreceptorsignalingpathwayviaJAK-STATregulationofcellshaperesponsetobacteriumsensoryperceptionofpainsignaltransductionviralgenomereplication
Rhodopsin
140
Guanine nucleotide-binding protein G(o) subunit alpha
351
9.6
68
0.15
OPSDGNAOP02699P09471absorptionofvisiblelightcellularresponsetolightstimulusdetectionoftemperaturestimulusinvolvedinthermoceptionGprotein-coupledreceptorsignalingpathwayphotoreceptorcellmaintenancephototransductionphototransductionvisiblelightproteinphosphorylationresponsetolightstimulusretinadevelopmentincamera-typeeyerhodopsinmediatedsignalingpathwaythermotaxisvisualperceptionadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaydopaminereceptorsignalingpathwaymusclecontraction
Histone H3.1t
111
Histone H3.1t
111
6.6
86
0.18
H31TH31TQ16695Q16695nucleosomeassembly
Potassium voltage-gated channel subfamily D member 3
93
Potassium voltage-gated channel subfamily D member 3
110
9.5
76
0.14
KCND3KCND3Q9UK17Q9UK17membranerepolarizationmembranerepolarizationduringcardiacmusclecellactionpotentialmembranerepolarizationduringventricularcardiacmusclecellactionpotentialpotassiumionexportacrossplasmamembranepotassiumiontransmembranetransportpotassiumiontransportproteinhomooligomerizationregulationofheartratebycardiacconductionregulationofiontransmembranetransportventricularcardiacmusclecellmembranerepolarization
Peptidyl-prolyl cis-trans isomerase FKBP2
97
Peptidyl-prolyl cis-trans isomerase FKBP2
97
8.5
68
0.17
FKBP2FKBP2P26885P26885chaperone-mediatedproteinfoldingproteinpeptidyl-prolylisomerization
Microtubule-associated proteins 1A/1B light chain 3A
17
Microtubule-associated proteins 1A/1B light chain 3A
17
8.8
66
0.17
MLP3AMLP3AQ9H492Q9H492autophagosomeassemblyautophagosomematurationautophagyofmitochondrioncellularresponsetoaminoacidstarvationcellularresponsetocopperioncellularresponsetohydrogenperoxidecellularresponsetonitrogenstarvationcellularresponsetostarvationmacroautophagyresponsetoiron(II)ionresponsetoleadionresponsetomorphine
Glycine N-methyltransferase
58
Glycine N-methyltransferase
186
8.5
77
0.15
GNMTGNMTQ9QXF8Q9QXF8glycinemetabolicprocessglycogenmetabolicprocessmethioninemetabolicprocessmethylationone-carbonmetabolicprocessproteinhomotetramerizationregulationofgluconeogenesisS-adenosylhomocysteinemetabolicprocessS-adenosylmethioninemetabolicprocesssarcosinemetabolicprocess
E3 ubiquitin-protein ligase RNF13
258
E3 ubiquitin-protein ligase RNF13
266
8.8
63
0.18
RNF13RNF13O43567O43567organellelocalizationpositiveregulationofstress-activatedproteinkinasesignalingcascadeproteinautoubiquitinationubiquitin-dependentproteincatabolicprocess
Serine/threonine-protein kinase TBK1
91
Serine/threonine-protein kinase TBK1
558
9.9
51
0.2
TBK1TBK1Q9UHD2Q9UHD2activationofinnateimmuneresponsedefenseresponsetoGram-positivebacteriumdefenseresponsetovirusdendriticcellproliferationI-kappaBkinase/NF-kappaBsignalinginflammatoryresponseinnateimmuneresponsenegativeregulationofgeneexpressionpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofmacroautophagypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftypeIinterferonproductionpositiveregulationoftypeIinterferon-mediatedsignalingpathwaypositiveregulationofxenophagyproteinphosphorylationregulationofneurondeathregulationoftypeIinterferonproductionresponsetovirustypeIinterferonsignalingpathway
Twinfilin-1
42
Twinfilin-1
42
8.8
81
0.14
TWF1TWF1Q91YR1Q91YR1actinfilamentdepolymerizationbarbed-endactinfilamentcappingnegativeregulationofactinfilamentpolymerizationpositiveregulationofcardiacmusclehypertrophypositiveregulationofneuronprojectiondevelopmentregulationofactinphosphorylationregulationoflamellipodiumassemblysequesteringofactinmonomers
Pancreatic secretory granule membrane major glycoprotein GP2
138
Pancreatic secretory granule membrane major glycoprotein GP2
172
8.8
73
0.16
GP2GP2P55259P55259antigentranscytosisbyMcellsinmucosal-associatedlymphoidtissueinnateimmuneresponseneutrophilmigration
Histone H3.3
111
Histone H3.3
111
6.1
82
0.2
H33H33P84244P84244cellpopulationproliferationDNAreplication-independentchromatinassemblyembryoimplantationmalegonaddevelopmentmulticellularorganismgrowthmusclecelldifferentiationnegativeregulationofchromosomecondensationnucleosomeassemblynucleusorganizationoocytematurationoogenesisosteoblastdifferentiationpericentricheterochromatinassemblypositiveregulationofcellgrowthregulationofcentromerecomplexassemblysinglefertilizationspermatiddevelopmentspermatogenesissubtelomericheterochromatinassembly
C-C motif chemokine 2
34
C-C motif chemokine 2
59
8.2
63
0.19
CCL2CCL2P13500P13500angiogenesisanimalorganmorphogenesisastrocytecellmigrationcelladhesioncellsurfacereceptorsignalingpathwaycellularhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetolipopolysaccharidecellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytokine-mediatedsignalingpathwaycytoskeletonorganizationeosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerhelperTcellextravasationhumoralimmuneresponseinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofglialcellapoptoticprocessnegativeregulationofnaturalkillercellchemotaxisnegativeregulationofneuronapoptoticprocessnegativeregulationofvascularendothelialcellproliferationneutrophilchemotaxispositiveregulationofapoptoticcellclearancepositiveregulationofcalciumionimportpositiveregulationofendothelialcellapoptoticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofNMDAglutamatereceptoractivitypositiveregulationofsynaptictransmissionglutamatergicpositiveregulationofTcellactivationproteinkinaseBsignalingproteinphosphorylationreceptorsignalingpathwayviaJAK-STATregulationofcellshaperesponsetobacteriumsensoryperceptionofpainsignaltransductionviralgenomereplication
Calcium/calmodulin-dependent protein kinase type 1G
214
Calcium/calmodulin-dependent protein kinase type 1G
180
9.5
80
0.13
KCC1GKCC1GQ96NX5Q96NX5peptidyl-serinephosphorylation
Glutamate receptor 2
78
Glutamate receptor 3
85
8.2
72
0.17
GRIA2GRIA3P19491P19492chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumion
Baculoviral IAP repeat-containing protein 2
315
Baculoviral IAP repeat-containing protein 2
315
6.5
41
0.38
BIRC2BIRC2Q13490Q13490cellsurfacereceptorsignalingpathwayI-kappaBkinase/NF-kappaBsignalingnecroptoticprocessnegativeregulationofapoptoticprocessnegativeregulationofnecroptoticprocessnegativeregulationofripoptosomeassemblyinvolvedinnecroptoticprocessNIK/NF-kappaBsignalingplacentadevelopmentpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofproteinK48-linkedubiquitinationpositiveregulationofproteinK63-linkedubiquitinationpositiveregulationofproteinmonoubiquitinationpositiveregulationofproteinubiquitinationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationregulationofapoptoticprocessregulationofcellcycleregulationofcelldifferentiationregulationofcellpopulationproliferationregulationofcysteine-typeendopeptidaseactivityregulationofinflammatoryresponseregulationofinnateimmuneresponseregulationofnecroptoticprocessregulationofNIK/NF-kappaBsignalingregulationofnucleotide-bindingoligomerizationdomaincontainingsignalingpathwayregulationofreactiveoxygenspeciesmetabolicprocessregulationofRIG-Isignalingpathwayregulationoftoll-likereceptorsignalingpathwayresponsetocAMPresponsetoethanolresponsetohypoxiatumornecrosisfactor-mediatedsignalingpathway
Transcription regulator protein BACH2
20
Transcription regulator protein BACH2
58
9.5
77
0.14
BACH2BACH2Q9BYV9Q9BYV9importintonucleusnegativeregulationoftranscriptionbyRNApolymeraseIIprimaryadaptiveimmuneresponseinvolvingTcellsandBcellsregulationoftranscriptionbyRNApolymeraseII
G-protein-signaling modulator 2
614
G-protein-signaling modulator 2
125
6.4
89
0.17
GPSM2GPSM2Q8VDU0Q8VDU0celldivisionestablishmentofmitoticspindleorientationmaintenanceofcentrosomelocationmitoticspindleorganizationpositiveregulationofproteinlocalizationtocellcortexpositiveregulationofspindleassemblyRanproteinsignaltransductionregulationofmitoticspindleorganization
DNA (cytosine-5)-methyltransferase 3A
559
DNA (cytosine-5)-methyltransferase 3A
497
8.2
85
0.14
DNM3ADNM3AQ9Y6K1Q9Y6K1agingC-5methylationofcytosinecellularresponsetoaminoacidstimuluscellularresponsetobisphenolAcellularresponsetoethanolcellularresponsetohypoxiaDNAmethylationDNAmethylationinvolvedinembryodevelopmentDNAmethylationinvolvedingametegenerationDNAmethylationoncytosineDNAmethylation-dependentheterochromatinassemblyhepatocyteapoptoticprocessmitoticcellcyclenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneurondifferentiationpositiveregulationofcelldeathregulationofgeneexpressionbygenomicimprintingresponsetococaineresponsetoestradiolresponsetoionizingradiationresponsetoleadionresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulusspermatogenesis
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
266
Succinate dehydrogenase assembly factor 2, mitochondrial
83
9.7
88
0.12
SDHASDHF2P31040Q9NX18mitochondrialelectrontransportsuccinatetoubiquinonenervoussystemdevelopmentprotonmotiveforce-drivenmitochondrialATPsynthesisrespiratoryelectrontransportchainsuccinatemetabolicprocesstricarboxylicacidcyclemitochondrialrespiratorychaincomplexIIassemblynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofepithelialtomesenchymaltransitionproteindephosphorylationprotein-FADlinkage
E3 ubiquitin-protein ligase RNF31
890
E3 ubiquitin-protein ligase RNF31
885
7.2
61
0.23
RNF31RNF31Q96EP0Q96EP0CD40signalingpathwaydefenseresponsetobacteriumnegativeregulationofnecroptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteintargetingtomitochondrionpositiveregulationofxenophagyproteinlinearpolyubiquitinationproteinpolyubiquitinationTcellreceptorsignalingpathway
Hepatocyte growth factor activator
448
Kunitz-type protease inhibitor 1
283
9.5
89
0.12
HGFASPIT1Q04756O43278bloodcoagulationproteolysiszymogenactivationbranchinginvolvedinlabyrinthinelayermorphogenesiscellularresponsetoBMPstimulusepidermisdevelopmentepitheliumdevelopmentextracellularmatrixorganizationnegativeregulationofneuralprecursorcellproliferationneuraltubeclosureplacentabloodvesseldevelopmentpositiveregulationofglialcelldifferentiation
Mothers against decapentaplegic homolog 3
320
Zinc finger FYVE domain-containing protein 9
783
8.7
73
0.16
SMAD3ZFYV9P84022O95405activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwayactivinreceptorsignalingpathwayadrenalglanddevelopmentanatomicalstructuremorphogenesisBMPsignalingpathwaycelldifferentiationcell-celljunctionorganizationcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetovirusdevelopmentalgrowthembryoniccranialskeletonmorphogenesisembryonicforegutmorphogenesisembryonicpatternspecificationendodermdevelopmentextrinsicapoptoticsignalingpathwayheartloopingimmuneresponseimmunesystemdevelopmentinuteroembryonicdevelopmentJNKcascadelensfibercelldifferentiationliverdevelopmentmesodermformationnegativeregulationofapoptoticprocessnegativeregulationofcardiacmusclehypertrophyinresponsetostressnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcytosoliccalciumionconcentrationnegativeregulationoffatcelldifferentiationnegativeregulationofinflammatoryresponsenegativeregulationoflungbloodpressurenegativeregulationofosteoblastdifferentiationnegativeregulationofosteoblastproliferationnegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofwoundhealingnodalsignalingpathwayosteoblastdevelopmentparaxialmesodermmorphogenesispericardiumdevelopmentpositiveregulationofalkalinephosphataseactivitypositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofchondrocytedifferentiationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofextracellularmatrixassemblypositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofinterleukin-1betaproductionpositiveregulationofmiRNAtranscriptionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofpositivechemotaxispositiveregulationofproteinimportintonucleuspositiveregulationofstressfiberassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransforminggrowthfactorbeta3productionprimarymiRNAprocessingproteinstabilizationregulationofbindingregulationofepithelialcellproliferationregulationofimmuneresponseregulationofmiRNAtranscriptionregulationofstriatedmuscletissuedevelopmentregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiasignaltransductioninvolvedinregulationofgeneexpressionSMADproteincomplexassemblySMADproteinsignaltransductionsomitogenesisTcellactivationthyroidglanddevelopmenttransdifferentiationtransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentwoundhealingendocytosisendosomaltransport
C-type lectin domain family 2 member I
92
C-type lectin domain family 2 member I
92
8.7
65
0.18
CLC2ICLC2IQ9WVF9Q9WVF9membraneraftassemblynegativeregulationofosteoclastdifferentiationpositiveregulationofimmunologicalsynapseformationreceptorclusteringregulationofactinfilamentpolymerizationregulationofinterleukin-2productionregulationofTcellproliferationTcellreceptorsignalingpathway
Mothers against decapentaplegic homolog 3
332
Zinc finger FYVE domain-containing protein 9
783
6.5
79
0.2
SMAD3ZFYV9P84022O95405activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwayactivinreceptorsignalingpathwayadrenalglanddevelopmentanatomicalstructuremorphogenesisBMPsignalingpathwaycelldifferentiationcell-celljunctionorganizationcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetovirusdevelopmentalgrowthembryoniccranialskeletonmorphogenesisembryonicforegutmorphogenesisembryonicpatternspecificationendodermdevelopmentextrinsicapoptoticsignalingpathwayheartloopingimmuneresponseimmunesystemdevelopmentinuteroembryonicdevelopmentJNKcascadelensfibercelldifferentiationliverdevelopmentmesodermformationnegativeregulationofapoptoticprocessnegativeregulationofcardiacmusclehypertrophyinresponsetostressnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcytosoliccalciumionconcentrationnegativeregulationoffatcelldifferentiationnegativeregulationofinflammatoryresponsenegativeregulationoflungbloodpressurenegativeregulationofosteoblastdifferentiationnegativeregulationofosteoblastproliferationnegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofwoundhealingnodalsignalingpathwayosteoblastdevelopmentparaxialmesodermmorphogenesispericardiumdevelopmentpositiveregulationofalkalinephosphataseactivitypositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofchondrocytedifferentiationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofextracellularmatrixassemblypositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofinterleukin-1betaproductionpositiveregulationofmiRNAtranscriptionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofpositivechemotaxispositiveregulationofproteinimportintonucleuspositiveregulationofstressfiberassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransforminggrowthfactorbeta3productionprimarymiRNAprocessingproteinstabilizationregulationofbindingregulationofepithelialcellproliferationregulationofimmuneresponseregulationofmiRNAtranscriptionregulationofstriatedmuscletissuedevelopmentregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiasignaltransductioninvolvedinregulationofgeneexpressionSMADproteincomplexassemblySMADproteinsignaltransductionsomitogenesisTcellactivationthyroidglanddevelopmenttransdifferentiationtransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentwoundhealingendocytosisendosomaltransport
PRSS3 protein
52
Amyloid beta precursor like protein 2
343
8.7
79
0.15
Q8N2U3APLP2Q8N2U3Q06481proteolysisaxonogenesiscentralnervoussystemdevelopmentGprotein-coupledreceptorsignalingpathwayregulationofcellularproteinmetabolicprocess
Cystatin-8
95
Cystatin-8
139
8.2
72
0.17
CST8CST8P32766P32766
Exocyst complex component 8
202
Exocyst complex component 8
202
6.5
74
0.21
EXOC8EXOC8O54924O54924endosomeorganizationexocytosisextracellularmatrixdisassemblyGolgitoplasmamembranetransportproteinlocalizationproteintransport
Synapsin-2
224
Synapsin-2
224
9.5
70
0.15
SYN2SYN2Q63537Q63537calcium-ionregulatedexocytosisneurotransmittersecretionregulationofneurotransmittersecretionsynapticvesicleclusteringsynapticvesiclecycle
Glucocorticoid receptor
473
Glucocorticoid receptor
473
9.5
78
0.13
GCRGCRP79269P79269cellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluschromatinorganizationpositiveregulationoftranscriptionbyRNApolymeraseII
Kinetochore-associated protein DSN1 homolog
191
Kinetochore-associated protein NSL1 homolog
53
9.5
69
0.15
DSN1NSL1Q9H410Q96IY1celldivisionmitoticsisterchromatidsegregation
ATP-citrate synthase
913
ATP-citrate synthase
913
9.5
103
0.1
ACLYACLYP53396P53396acetyl-CoAbiosyntheticprocesscholesterolbiosyntheticprocesscitratemetabolicprocesscoenzymeAmetabolicprocessfattyacidbiosyntheticprocesslipidbiosyntheticprocessoxaloacetatemetabolicprocess
E3 ubiquitin-protein ligase RNF13
278
E3 ubiquitin-protein ligase RNF13
243
9.7
68
0.15
RNF13RNF13O43567O43567organellelocalizationpositiveregulationofstress-activatedproteinkinasesignalingcascadeproteinautoubiquitinationubiquitin-dependentproteincatabolicprocess
Ephrin type-A receptor 4
108
Ephrin type-A receptor 4
108
8.2
80
0.15
EPHA4EPHA4P54764P54764adherensjunctionorganizationadultwalkingbehavioraxonguidancecelladhesioncellularresponsetoamyloid-betacochleadevelopmentcorticospinaltractmorphogenesisephrinreceptorsignalingpathwayfasciculationofmotorneuronaxonfasciculationofsensoryneuronaxonglialcellmigrationmotorneuronaxonguidancenegativeregulationofaxonregenerationnegativeregulationofcelladhesionnegativeregulationofcellmigrationnegativeregulationofcellularresponsetohypoxianegativeregulationofepithelialtomesenchymaltransitionnegativeregulationofERK1andERK2cascadenegativeregulationoflong-termsynapticpotentiationnegativeregulationofneuronprojectiondevelopmentnegativeregulationofproteolysisinvolvedinproteincatabolicprocessnephricductmorphogenesisneuronprojectionfasciculationneuronprojectionguidancepeptidyl-tyrosinephosphorylationpositiveregulationofamyloid-betaformationpositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdendritemorphogenesispositiveregulationofJUNkinaseactivitypositiveregulationofkinaseactivitypositiveregulationofproteintyrosinekinaseactivitypositiveregulationofRhoguanyl-nucleotideexchangefactoractivityproteinautophosphorylationproteinstabilizationregulationofastrocytedifferentiationregulationofaxonogenesisregulationofdendriticspinemorphogenesisregulationofGTPaseactivityregulationofmodificationofsynapticstructuresynapsepruningtransmembranereceptorproteintyrosinekinasesignalingpathway
Actin, alpha skeletal muscle
376
Actin, alpha skeletal muscle
376
6.5
57
0.27
ACTSACTSP68135P68135actinfilamentbundleassemblyactinfilamentpolymerizationmesenchymemigrationpositiveregulationofgeneexpressionskeletalmusclefiberdevelopmentskeletalmusclethinfilamentassembly
Lysozyme C
99
Lysozyme C
99
7.2
91
0.15
LYSCLYSCP61626P61626antimicrobialhumoralresponsecytolysisdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminflammatoryresponsekillingofcellsofanotherorganismmetabolicprocessretinahomeostasis
Mineralocorticoid receptor
639
Mineralocorticoid receptor
655
9.7
71
0.15
MCRMCRP08235P08235intracellularsteroidhormonereceptorsignalingpathwaypositiveregulationofNIK/NF-kappaBsignalingregulationoftranscriptionbyRNApolymeraseIIsignaltransduction
Zinc finger and BTB domain-containing protein 17
26
Zinc finger and BTB domain-containing protein 17
26
9.7
71
0.15
ZBT17ZBT17Q13105Q13105ectodermdevelopmentG1toG0transitiongastrulationwithmouthformingsecondnegativeregulationofcellcyclenegativeregulationofcellpopulationproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Thiopurine S-methyltransferase
165
Thiopurine S-methyltransferase
165
8.4
66
0.18
TPMTTPMTO43213O43213methylationnucleobase-containingcompoundmetabolicprocessxenobioticcatabolicprocessxenobioticmetabolicprocess
Pleckstrin homology domain-containing family A member 7
193
Pleckstrin homology domain-containing family A member 7
193
8.7
87
0.13
PKHA7PKHA7Q6IQ23Q6IQ23cell-celladhesionmediatedbycadherinepithelialcell-celladhesionporecomplexassemblyzonulaadherensmaintenance
CDC42BPB protein
41
CDC42BPB protein
41
9.7
71
0.15
Q86XZ8Q86XZ8Q86XZ8Q86XZ8actincytoskeletonorganizationcellmigrationproteinphosphorylation
Fructose-bisphosphatase
129
Fructose-bisphosphatase
184
8.9
72
0.16
Q2TU34Q2TU34Q2TU34Q2TU34gluconeogenesis
Frizzled-8
107
Frizzled-8
107
9.7
74
0.14
FZD8FZD8Q61091Q61091angiogenesiscanonicalWntsignalingpathwaypositiveregulationofJUNkinaseactivitypositiveregulationofproteinphosphorylationTcelldifferentiationinthymusWntsignalingpathway
MIT domain-containing protein 1
37
MIT domain-containing protein 1
37
6.5
93
0.17
MITD1MITD1Q8WV92Q8WV92midbodyabscissionmitoticcytokinesisnegativeregulationofproteinbinding
Asparagine synthetase [glutamine-hydrolyzing]
18
Asparagine synthetase [glutamine-hydrolyzing]
44
9.5
91
0.12
ASNSASNSP08243P08243asparaginebiosyntheticprocesscellularresponsetoglucosestarvationglutaminemetabolicprocessL-asparaginebiosyntheticprocessnegativeregulationofapoptoticprocesspositiveregulationofmitoticcellcycle
Poly [ADP-ribose] polymerase
973
Poly [ADP-ribose] polymerase
973
8.2
59
0.21
Q59FX0Q59FX0Q59FX0Q59FX0positiveregulationoftelomeremaintenanceviatelomerasespindleassemblyWntsignalingpathway
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
157
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
157
7.1
77
0.18
PDE1BPDE1BQ01064Q01064cellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimuluscellularresponsetomacrophagecolony-stimulatingfactorstimuluslocomotorybehaviormonocytedifferentiationregulationofdopaminemetabolicprocessregulationofneurotransmitterlevelsresponsetoamphetamineserotoninmetabolicprocesssignaltransductionvisuallearning
Albumin
192
Albumin
538
9.7
69
0.15
ALBUALBUP02768P02768cellularresponsetostarvationmaintenanceofmitochondrionlocationnegativeregulationofapoptoticprocessnegativeregulationofprogrammedcelldeathretinahomeostasis
Proproteinase E
227
Proproteinase E
227
6.4
96
0.16
CAC3CAC3P05805P05805digestionproteolysis
DNA dC->dU-editing enzyme APOBEC-3A
64
DNA dC->dU-editing enzyme APOBEC-3A
171
9.5
27
0.39
ABC3AABC3AP31941P31941cellularresponsetoxenobioticstimulusclearanceofforeignintracellularDNAcytidinetouridineeditingdefenseresponsetovirusDNAcytosinedeaminationDNAdemethylationinnateimmuneresponsenegativeregulationofsinglestrandedviralRNAreplicationviadoublestrandedDNAintermediatenegativeregulationoftranspositionnegativeregulationofviralgenomereplication
Transcription factor Dp-1
274
Transcription factor Dp-1
274
6.7
68
0.22
TFDP1TFDP1Q14186Q14186anoikisepidermisdevelopmentnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationoffatcellproliferationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNAbiosyntheticprocessregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptioninvolvedinG1/StransitionofmitoticcellcycletranscriptionbyRNApolymeraseII
C-C motif chemokine 5
73
C-C motif chemokine 5
33
9.9
75
0.13
CCL5CCL5P13501P13501activationofphospholipaseDactivitycalciumiontransportcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetoviruschemokine-mediatedsignalingpathwaychemotaxisdendriticcellchemotaxiseosinophilchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwayinflammatoryresponseleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofinnateimmuneresponsepositiveregulationofmacrophagechemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftranslationalinitiationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofviralgenomereplicationproteinkinaseBsignalingregulationofchronicinflammatoryresponseregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetotoxicsubstanceresponsetovirus
Cardiac phospholamban
36
Cardiac phospholamban
36
9.6
60
0.17
PPLAPPLAP61015P61015adenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocesscardiacmuscletissuedevelopmentcellularcalciumionhomeostasismusclecellcellularhomeostasisnegativeregulationofATPase-coupledcalciumtransmembranetransporteractivitynegativeregulationofcalciumionbindingnegativeregulationofcalciumionimportnegativeregulationofcalciumionimportintosarcoplasmicreticulumnegativeregulationofcalciumiontransmembranetransporteractivitynegativeregulationofcatalyticactivitynegativeregulationofheartrateNotchsignalingpathwayregulationofcalciumiontransportregulationofcardiacmusclecellcontractionregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofrelaxationofmuscleregulationofryanodine-sensitivecalcium-releasechannelactivityregulationoftheforceofheartcontractionbycardiacconduction
Cardiac phospholamban
41
Cardiac phospholamban
41
9.5
60
0.17
PPLAPPLAP61015P61015adenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocesscardiacmuscletissuedevelopmentcellularcalciumionhomeostasismusclecellcellularhomeostasisnegativeregulationofATPase-coupledcalciumtransmembranetransporteractivitynegativeregulationofcalciumionbindingnegativeregulationofcalciumionimportnegativeregulationofcalciumionimportintosarcoplasmicreticulumnegativeregulationofcalciumiontransmembranetransporteractivitynegativeregulationofcatalyticactivitynegativeregulationofheartrateNotchsignalingpathwayregulationofcalciumiontransportregulationofcardiacmusclecellcontractionregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofrelaxationofmuscleregulationofryanodine-sensitivecalcium-releasechannelactivityregulationoftheforceofheartcontractionbycardiacconduction
Cardiac phospholamban
41
Cardiac phospholamban
36
9.9
59
0.17
PPLAPPLAP61015P61015adenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocesscardiacmuscletissuedevelopmentcellularcalciumionhomeostasismusclecellcellularhomeostasisnegativeregulationofATPase-coupledcalciumtransmembranetransporteractivitynegativeregulationofcalciumionbindingnegativeregulationofcalciumionimportnegativeregulationofcalciumionimportintosarcoplasmicreticulumnegativeregulationofcalciumiontransmembranetransporteractivitynegativeregulationofcatalyticactivitynegativeregulationofheartrateNotchsignalingpathwayregulationofcalciumiontransportregulationofcardiacmusclecellcontractionregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofrelaxationofmuscleregulationofryanodine-sensitivecalcium-releasechannelactivityregulationoftheforceofheartcontractionbycardiacconduction
Cardiac phospholamban
41
Cardiac phospholamban
36
4.9
64
0.32
PPLAPPLAP26678P26678adenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocessbloodcirculationcardiacmuscletissuedevelopmentmusclecellcellularhomeostasisnegativeregulationofATP-dependentactivitynegativeregulationofATPase-coupledcalciumtransmembranetransporteractivitynegativeregulationofcalciumionbindingnegativeregulationofcalciumionimportnegativeregulationofcalciumionimportintosarcoplasmicreticulumnegativeregulationofcalciumiontransmembranetransporteractivitynegativeregulationofcalciumiontransportnegativeregulationofcatalyticactivitynegativeregulationofheartrateNotchsignalingpathwayregulationofATPase-coupledcalciumtransmembranetransporteractivityregulationofcalciumiontransportregulationofcardiacmusclecellcontractionregulationofcardiacmusclecellmembranepotentialregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofcytosoliccalciumionconcentrationregulationofheartcontractionregulationofrelaxationofcardiacmuscleregulationofryanodine-sensitivecalcium-releasechannelactivityregulationoftheforceofheartcontractionregulationoftheforceofheartcontractionbycardiacconductionrelaxationofcardiacmuscle
T-cell surface glycoprotein CD4
447
Tyrosine-protein kinase Lck
23
3.8
32
0.81
CD4LCKP01730P06239adaptiveimmuneresponsecalcium-mediatedsignalingcelladhesioncellsurfacereceptorsignalingpathwaycellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimulusdefenseresponsetoGram-negativebacteriumenzyme-linkedreceptorproteinsignalingpathwayhelperTcellenhancementofadaptiveimmuneresponseimmuneresponseinterleukin-15-mediatedsignalingpathwaymacrophagedifferentiationmaintenanceofproteinlocationincellpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofERK1andERK2cascadepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-2productionpositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmonocytedifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofTcellactivationpositiveregulationoftranscriptionDNA-templatedpositiveregulationofviralentryintohostcellregulationofcalciumiontransportregulationofTcellactivationsignaltransductionTcellactivationTcelldifferentiationTcellselectiontransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessBcellreceptorsignalingpathwaycelldifferentiationcellularzincionhomeostasisFc-gammareceptorsignalingpathwayhemopoiesisinnateimmuneresponseintracellularsignaltransductionleukocytemigrationpeptidyl-tyrosineautophosphorylationplateletactivationpositiveregulationofheterotypiccell-celladhesionpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofleukocytecell-celladhesionpositiveregulationofTcellreceptorsignalingpathwayproteinphosphorylationregulationoflymphocyteactivationreleaseofsequesteredcalciumionintocytosolresponsetoxenobioticstimulusTcellcostimulationTcellreceptorsignalingpathway
Cardiac phospholamban
36
Cardiac phospholamban
36
7.2
64
0.22
PPLAPPLAP26678P26678adenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocessbloodcirculationcardiacmuscletissuedevelopmentmusclecellcellularhomeostasisnegativeregulationofATP-dependentactivitynegativeregulationofATPase-coupledcalciumtransmembranetransporteractivitynegativeregulationofcalciumionbindingnegativeregulationofcalciumionimportnegativeregulationofcalciumionimportintosarcoplasmicreticulumnegativeregulationofcalciumiontransmembranetransporteractivitynegativeregulationofcalciumiontransportnegativeregulationofcatalyticactivitynegativeregulationofheartrateNotchsignalingpathwayregulationofATPase-coupledcalciumtransmembranetransporteractivityregulationofcalciumiontransportregulationofcardiacmusclecellcontractionregulationofcardiacmusclecellmembranepotentialregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofcytosoliccalciumionconcentrationregulationofheartcontractionregulationofrelaxationofcardiacmuscleregulationofryanodine-sensitivecalcium-releasechannelactivityregulationoftheforceofheartcontractionregulationoftheforceofheartcontractionbycardiacconductionrelaxationofcardiacmuscle
Defensin alpha-like protein 1
67
Defensin alpha-like protein 1
77
4.7
68
0.31
DFAL1DFAL1Q4JEI2Q4JEI2antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosamembranedisruptioninanotherorganism
Trefoil factor 3
42
Trefoil factor 3
78
8.2
76
0.16
TFF3TFF3Q07654Q07654maintenanceofgastrointestinalepitheliumregulationofglucosemetabolicprocess
C-C motif chemokine 5
33
C-C motif chemokine 5
57
6.8
60
0.25
CCL5CCL5P30882P30882activationofphospholipaseDactivitycalciumiontransportcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwayeosinophilchemotaxisepithelialcellproliferationexocytosisGprotein-coupledreceptorsignalingpathwayinflammatoryresponseleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofcelldeathnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofmacrophageapoptoticprocessnegativeregulationofneurondeathnegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofangiogenesispositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofchemokine(C-X-Cmotif)ligand2productionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffevergenerationpositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofmacrophagechemotaxispositiveregulationofmastcellchemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofneurondifferentiationpositiveregulationofosteoclastdifferentiationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinproteinkinaseBsignalingpseudopodiumassemblyregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetocytokineresponsetointerferon-gammaresponsetotoxicsubstanceresponsetotumornecrosisfactorT-helper1celldiapedesis
Defensin alpha-like protein 1
75
Defensin alpha-like protein 1
65
4.1
72
0.34
DFAL1DFAL1Q4JEI2Q4JEI2antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosamembranedisruptioninanotherorganism
Defensin alpha-like protein 1
65
Defensin alpha-like protein 1
67
7.1
68
0.21
DFAL1DFAL1Q4JEI2Q4JEI2antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosamembranedisruptioninanotherorganism
T-cell surface glycoprotein CD4
445
Tyrosine-protein kinase Lck
20
3.8
40
0.65
CD4LCKP01730P06239adaptiveimmuneresponsecalcium-mediatedsignalingcelladhesioncellsurfacereceptorsignalingpathwaycellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimulusdefenseresponsetoGram-negativebacteriumenzyme-linkedreceptorproteinsignalingpathwayhelperTcellenhancementofadaptiveimmuneresponseimmuneresponseinterleukin-15-mediatedsignalingpathwaymacrophagedifferentiationmaintenanceofproteinlocationincellpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofERK1andERK2cascadepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-2productionpositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmonocytedifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofTcellactivationpositiveregulationoftranscriptionDNA-templatedpositiveregulationofviralentryintohostcellregulationofcalciumiontransportregulationofTcellactivationsignaltransductionTcellactivationTcelldifferentiationTcellselectiontransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessBcellreceptorsignalingpathwaycelldifferentiationcellularzincionhomeostasisFc-gammareceptorsignalingpathwayhemopoiesisinnateimmuneresponseintracellularsignaltransductionleukocytemigrationpeptidyl-tyrosineautophosphorylationplateletactivationpositiveregulationofheterotypiccell-celladhesionpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofleukocytecell-celladhesionpositiveregulationofTcellreceptorsignalingpathwayproteinphosphorylationregulationoflymphocyteactivationreleaseofsequesteredcalciumionintocytosolresponsetoxenobioticstimulusTcellcostimulationTcellreceptorsignalingpathway
Trefoil factor 3
78
Trefoil factor 3
57
7.1
85
0.17
TFF3TFF3Q07654Q07654maintenanceofgastrointestinalepitheliumregulationofglucosemetabolicprocess
Transcription factor HES-1
117
Transcription factor HES-1
117
4.0
82
0.31
HES1HES1Q14469Q14469adenohypophysisdevelopmentamacrinecelldifferentiationanterior/posteriorpatternspecificationarterymorphogenesisascendingaortamorphogenesisBMPsignalingpathwayCajal-Retziuscelldifferentiationcardiacneuralcrestcelldevelopmentinvolvedinoutflowtractmorphogenesiscelladhesioncellfatedeterminationcellmaturationcellmigrationcellmorphogenesisinvolvedinneurondifferentiationcellularresponsetofattyacidcellularresponsetointerleukin-1cellularresponsetonervegrowthfactorstimuluscellularresponsetotumornecrosisfactorcochleadevelopmentcomma-shapedbodymorphogenesiscommonbileductdevelopmentembryonichearttubemorphogenesisestablishmentofepithelialcellpolarityforebrainradialglialcelldifferentiationglomerulusvasculaturedevelopmenthindbrainmorphogenesisinnerearauditoryreceptorcelldifferentiationinnerearreceptorcellstereociliumorganizationlabyrinthinelayerbloodvesseldevelopmentlateralinhibitionliverdevelopmentlungdevelopmentmetanephricnephrontubulemorphogenesismidbraindevelopmentmidbrain-hindbrainboundarymorphogenesisnegativeregulationofamacrinecelldifferentiationnegativeregulationofcalciumionimportnegativeregulationofcellfatedeterminationnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofforebrainneurondifferentiationnegativeregulationofgeneexpressionnegativeregulationofglialcellproliferationnegativeregulationofinnerearauditoryreceptorcelldifferentiationnegativeregulationofneurondifferentiationnegativeregulationofneuronprojectiondevelopmentnegativeregulationofoligodendrocytedifferentiationnegativeregulationofpancreaticAcelldifferentiationnegativeregulationofpro-BcelldifferentiationnegativeregulationofstemcelldifferentiationnegativeregulationofstomachneuroendocrinecelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednervoussystemdevelopmentneuronalstemcellpopulationmaintenanceNotchsignalingpathwayoculomotornervedevelopmentoutflowtractmorphogenesispancreaticAcelldifferentiationpharyngealarcharterymorphogenesispositiveregulationofastrocytedifferentiationpositiveregulationofBMPsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofgeneexpressionpositiveregulationofmitoticcellcycleembryonicpositiveregulationofNotchsignalingpathwaypositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofTcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftyrosinephosphorylationofSTATproteinprotein-containingcomplexassemblyregulationofepithelialcellproliferationregulationoffatcelldifferentiationregulationofneurogenesisregulationofprotein-containingcomplexassemblyregulationofreceptorsignalingpathwayviaJAK-STATregulationofsecondaryheartfieldcardioblastproliferationregulationoftimingofneurondifferentiationregulationoftranscriptionbyRNApolymeraseIIrenalinterstitialfibroblastdevelopmentresponsetoalkaloidresponsetoorganiccycliccompoundresponsetothyroidhormoneS-shapedbodymorphogenesissmoothenedsignalingpathwaysomaticstemcellpopulationmaintenancestomachneuroendocrinecelldifferentiationTcellproliferationtelencephalondevelopmentthymusdevelopmenttrochlearnervedevelopmenturetericbudmorphogenesisvascularassociatedsmoothmusclecelldevelopmentventricularseptumdevelopmentventricularseptummorphogenesis
C-C motif chemokine 5
33
C-C motif chemokine 5
33
6.1
72
0.23
CCL5CCL5P30882P30882activationofphospholipaseDactivitycalciumiontransportcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwayeosinophilchemotaxisepithelialcellproliferationexocytosisGprotein-coupledreceptorsignalingpathwayinflammatoryresponseleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofcelldeathnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofmacrophageapoptoticprocessnegativeregulationofneurondeathnegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofangiogenesispositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofchemokine(C-X-Cmotif)ligand2productionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffevergenerationpositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofmacrophagechemotaxispositiveregulationofmastcellchemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofneurondifferentiationpositiveregulationofosteoclastdifferentiationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinproteinkinaseBsignalingpseudopodiumassemblyregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetocytokineresponsetointerferon-gammaresponsetotoxicsubstanceresponsetotumornecrosisfactorT-helper1celldiapedesis
Tumor necrosis factor receptor superfamily member 10B
232
Tumor necrosis factor receptor superfamily member 10B
232
5.2
40
0.48
TR10BTR10BO14763O14763activationofNF-kappaB-inducingkinaseactivityapoptoticprocesscellsurfacereceptorsignalingpathwaycellularresponsetomechanicalstimulusdefenseresponsetotumorcellextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstresspositiveregulationofapoptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingregulationofapoptoticprocessresponsetoendoplasmicreticulumstressTRAIL-activatedapoptoticsignalingpathway
T-cell surface glycoprotein CD8 alpha chain
215
Tyrosine-protein kinase Lck
20
3.8
44
0.59
CD8ALCKP01732P06239adaptiveimmuneresponseantigenprocessingandpresentationcellsurfacereceptorsignalingpathwaycytotoxicTcelldifferentiationimmuneresponseTcellactivationTcellmediatedimmunityTcellreceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessBcellreceptorsignalingpathwaycelldifferentiationcellularzincionhomeostasisFc-gammareceptorsignalingpathwayhemopoiesisinnateimmuneresponseintracellularsignaltransductionleukocytemigrationpeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationplateletactivationpositiveregulationofheterotypiccell-celladhesionpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofleukocytecell-celladhesionpositiveregulationofTcellactivationpositiveregulationofTcellreceptorsignalingpathwayproteinphosphorylationregulationoflymphocyteactivationreleaseofsequesteredcalciumionintocytosolresponsetoxenobioticstimulusTcellcostimulationTcelldifferentiation
Defensin alpha-like protein 1
67
Defensin alpha-like protein 1
67
7.1
64
0.22
DFAL1DFAL1Q4JEI2Q4JEI2antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosamembranedisruptioninanotherorganism
Protein S100-A11
13
Protein S100-A11
13
4.1
78
0.31
S10ABS10ABP31949P31949negativeregulationofcellpopulationproliferationnegativeregulationofDNAreplicationpositiveregulationofsmoothmusclecellmigrationsignaltransduction
Transcription factor HES-1
128
Transcription factor HES-1
128
4.9
54
0.38
HES1HES1Q14469Q14469adenohypophysisdevelopmentamacrinecelldifferentiationanterior/posteriorpatternspecificationarterymorphogenesisascendingaortamorphogenesisBMPsignalingpathwayCajal-Retziuscelldifferentiationcardiacneuralcrestcelldevelopmentinvolvedinoutflowtractmorphogenesiscelladhesioncellfatedeterminationcellmaturationcellmigrationcellmorphogenesisinvolvedinneurondifferentiationcellularresponsetofattyacidcellularresponsetointerleukin-1cellularresponsetonervegrowthfactorstimuluscellularresponsetotumornecrosisfactorcochleadevelopmentcomma-shapedbodymorphogenesiscommonbileductdevelopmentembryonichearttubemorphogenesisestablishmentofepithelialcellpolarityforebrainradialglialcelldifferentiationglomerulusvasculaturedevelopmenthindbrainmorphogenesisinnerearauditoryreceptorcelldifferentiationinnerearreceptorcellstereociliumorganizationlabyrinthinelayerbloodvesseldevelopmentlateralinhibitionliverdevelopmentlungdevelopmentmetanephricnephrontubulemorphogenesismidbraindevelopmentmidbrain-hindbrainboundarymorphogenesisnegativeregulationofamacrinecelldifferentiationnegativeregulationofcalciumionimportnegativeregulationofcellfatedeterminationnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofforebrainneurondifferentiationnegativeregulationofgeneexpressionnegativeregulationofglialcellproliferationnegativeregulationofinnerearauditoryreceptorcelldifferentiationnegativeregulationofneurondifferentiationnegativeregulationofneuronprojectiondevelopmentnegativeregulationofoligodendrocytedifferentiationnegativeregulationofpancreaticAcelldifferentiationnegativeregulationofpro-BcelldifferentiationnegativeregulationofstemcelldifferentiationnegativeregulationofstomachneuroendocrinecelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednervoussystemdevelopmentneuronalstemcellpopulationmaintenanceNotchsignalingpathwayoculomotornervedevelopmentoutflowtractmorphogenesispancreaticAcelldifferentiationpharyngealarcharterymorphogenesispositiveregulationofastrocytedifferentiationpositiveregulationofBMPsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofgeneexpressionpositiveregulationofmitoticcellcycleembryonicpositiveregulationofNotchsignalingpathwaypositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofTcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftyrosinephosphorylationofSTATproteinprotein-containingcomplexassemblyregulationofepithelialcellproliferationregulationoffatcelldifferentiationregulationofneurogenesisregulationofprotein-containingcomplexassemblyregulationofreceptorsignalingpathwayviaJAK-STATregulationofsecondaryheartfieldcardioblastproliferationregulationoftimingofneurondifferentiationregulationoftranscriptionbyRNApolymeraseIIrenalinterstitialfibroblastdevelopmentresponsetoalkaloidresponsetoorganiccycliccompoundresponsetothyroidhormoneS-shapedbodymorphogenesissmoothenedsignalingpathwaysomaticstemcellpopulationmaintenancestomachneuroendocrinecelldifferentiationTcellproliferationtelencephalondevelopmentthymusdevelopmenttrochlearnervedevelopmenturetericbudmorphogenesisvascularassociatedsmoothmusclecelldevelopmentventricularseptumdevelopmentventricularseptummorphogenesis
Cyclin-dependent kinase 2-associated protein 2
116
Cyclin-dependent kinase 2-associated protein 2
116
7.1
75
0.19
CDKA2CDKA2O75956O75956negativeregulationofG1/Stransitionofmitoticcellcycleregulationofmicrotubulecytoskeletonorganizationregulationofstemcelldivision
Relaxin-3
35
Insulin-like peptide INSL5
121
6.9
49
0.3
REL3INSL5Q8WXF3Q9Y5Q6positiveregulationoffeedingbehavior
Defensin alpha-like protein 1
75
Defensin alpha-like protein 1
77
4.9
74
0.28
DFAL1DFAL1Q4JEI2Q4JEI2antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosamembranedisruptioninanotherorganism
Zinc finger HIT domain-containing protein 3
143
FMR1-interacting protein NUFIP1
473
3.8
84
0.31
ZNHI3NUFP1Q15649Q9UHK0boxC/DsnoRNPassemblymaturationofLSU-rRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)regulationoftranscriptionDNA-templatedsnoRNAlocalizationpositiveregulationoftranscriptionbyRNApolymeraseIIRNAprocessing
Relaxin-3
35
Insulin-like peptide INSL5
126
8.2
54
0.23
REL3INSL5Q8WXF3Q9Y5Q6positiveregulationoffeedingbehavior
Defensin alpha-like protein 1
77
Defensin alpha-like protein 1
77
4.0
72
0.35
DFAL1DFAL1Q4JEI2Q4JEI2antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosamembranedisruptioninanotherorganism
Cyclin-dependent kinase 2-associated protein 1
105
Cyclin-dependent kinase 2-associated protein 1
105
6.9
57
0.26
CDKA1CDKA1O14519O14519cellcycleDNA-templatedDNAreplicationpositiveregulationofproteinphosphorylation
T-cell surface glycoprotein CD8 alpha chain
217
Tyrosine-protein kinase Lck
23
3.8
34
0.77
CD8ALCKP01732P06239adaptiveimmuneresponseantigenprocessingandpresentationcellsurfacereceptorsignalingpathwaycytotoxicTcelldifferentiationimmuneresponseTcellactivationTcellmediatedimmunityTcellreceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessBcellreceptorsignalingpathwaycelldifferentiationcellularzincionhomeostasisFc-gammareceptorsignalingpathwayhemopoiesisinnateimmuneresponseintracellularsignaltransductionleukocytemigrationpeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationplateletactivationpositiveregulationofheterotypiccell-celladhesionpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofleukocytecell-celladhesionpositiveregulationofTcellactivationpositiveregulationofTcellreceptorsignalingpathwayproteinphosphorylationregulationoflymphocyteactivationreleaseofsequesteredcalciumionintocytosolresponsetoxenobioticstimulusTcellcostimulationTcelldifferentiation
Defensin alpha-like protein 1
65
Defensin alpha-like protein 1
65
4.5
70
0.32
DFAL1DFAL1Q4JEI2Q4JEI2antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosamembranedisruptioninanotherorganism
T-cell surface glycoprotein CD4
447
Tyrosine-protein kinase Lck
20
3.8
35
0.75
CD4LCKP01730P06239adaptiveimmuneresponsecalcium-mediatedsignalingcelladhesioncellsurfacereceptorsignalingpathwaycellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimulusdefenseresponsetoGram-negativebacteriumenzyme-linkedreceptorproteinsignalingpathwayhelperTcellenhancementofadaptiveimmuneresponseimmuneresponseinterleukin-15-mediatedsignalingpathwaymacrophagedifferentiationmaintenanceofproteinlocationincellpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofERK1andERK2cascadepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-2productionpositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmonocytedifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofTcellactivationpositiveregulationoftranscriptionDNA-templatedpositiveregulationofviralentryintohostcellregulationofcalciumiontransportregulationofTcellactivationsignaltransductionTcellactivationTcelldifferentiationTcellselectiontransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessBcellreceptorsignalingpathwaycelldifferentiationcellularzincionhomeostasisFc-gammareceptorsignalingpathwayhemopoiesisinnateimmuneresponseintracellularsignaltransductionleukocytemigrationpeptidyl-tyrosineautophosphorylationplateletactivationpositiveregulationofheterotypiccell-celladhesionpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofleukocytecell-celladhesionpositiveregulationofTcellreceptorsignalingpathwayproteinphosphorylationregulationoflymphocyteactivationreleaseofsequesteredcalciumionintocytosolresponsetoxenobioticstimulusTcellcostimulationTcellreceptorsignalingpathway
Defensin alpha-like protein 1
75
Defensin alpha-like protein 1
75
4.7
74
0.29
DFAL1DFAL1Q4JEI2Q4JEI2antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosamembranedisruptioninanotherorganism
Insulin
104
Insulin
43
3.8
46
0.57
INSINSP01317P01317estradiolsecretionfeedingbehaviorglucoseimportinresponsetoinsulinstimulusglucosemetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofappetitenegativeregulationoflactationnegativeregulationoflipidcatabolicprocesspositiveregulationofbloodcirculationpositiveregulationofcellmaturationpositiveregulationofgeneexpressionpositiveregulationofinsulinsecretionpositiveregulationoflactationpositiveregulationofmammaryglandepithelialcellproliferationpositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRhoproteinsignaltransductionproteinsecretionresponsetobutyrateresponsetofoodresponsetoglucoseresponsetogrowthhormoneresponsetoheatresponsetoL-arginineresponsetonutrientlevels
Beta-nerve growth factor
189
Beta-nerve growth factor
189
7.2
64
0.22
NGFNGFP01138P01138activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsmemorymodulationofchemicalsynaptictransmissionnegativeregulationofcellpopulationproliferationnegativeregulationofneuronapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwayneuronapoptoticprocessneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofcollateralsproutingpositiveregulationofDNAbindingpositiveregulationofgeneexpressionpositiveregulationofneurondifferentiationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofRasproteinsignaltransductionregulationofneurondifferentiationtransmembranereceptorproteintyrosinekinasesignalingpathway
Tumor necrosis factor receptor superfamily member 16
381
Tumor necrosis factor receptor type 1-associated DEATH domain protein
241
7.2
71
0.2
TNR16TRADDP08138Q15628activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessaxonguidancecellularglucosehomeostasiscellularresponsetoamyloid-betacentralnervoussystemdevelopmentcircadianregulationofgeneexpressiondetectionoftemperaturestimulusdorsalaortadevelopmentfibroblastgrowthfactorreceptorsignalingpathwayfibroblastproliferationglucosehomeostasishairfolliclemorphogenesisintracellularproteintransportnegativeregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisnegativeregulationofcellmigrationnegativeregulationoffibroblastgrowthfactorreceptorsignalingpathwaynegativeregulationofhairfollicledevelopmentnervedevelopmentneuronapoptoticprocessodontogenesisofdentin-containingtoothpositiveregulationofapoptoticsignalingpathwaypositiveregulationoffibroblastproliferationpositiveregulationofmiRNAtranscriptionpositiveregulationofodontogenesisofdentin-containingtoothpositiveregulationofproteinlocalizationtonucleusRhoproteinsignaltransductionapoptoticprocesscellularresponsetotumornecrosisfactorextrinsicapoptoticsignalingpathwayextrinsicapoptoticsignalingpathwayviadeathdomainreceptorspositiveregulationofapoptoticprocesspositiveregulationofcellmigrationpositiveregulationofhairfollicledevelopmentpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinflammatoryresponsepositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingsignaltransductiontumornecrosisfactor-mediatedsignalingpathway
Insulin-like 3
115
Insulin-like 3
34
7.2
59
0.23
INSL3INSL3P51460P51460adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaycell-cellsignalingmalegonaddevelopmentnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationoocytematurationpositiveregulationofcAMP-mediatedsignalingpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofwoundhealingspermatogenesis
Insulin
91
Insulin
31
5.3
49
0.39
INSINSP01317P01317estradiolsecretionfeedingbehaviorglucoseimportinresponsetoinsulinstimulusglucosemetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofappetitenegativeregulationoflactationnegativeregulationoflipidcatabolicprocesspositiveregulationofbloodcirculationpositiveregulationofcellmaturationpositiveregulationofgeneexpressionpositiveregulationofinsulinsecretionpositiveregulationoflactationpositiveregulationofmammaryglandepithelialcellproliferationpositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRhoproteinsignaltransductionproteinsecretionresponsetobutyrateresponsetofoodresponsetoglucoseresponsetogrowthhormoneresponsetoheatresponsetoL-arginineresponsetonutrientlevels
Tumor necrosis factor receptor superfamily member 16
381
Tumor necrosis factor receptor superfamily member 16
381
6.9
74
0.2
TNR16TNR16P08138P08138activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessaxonguidancecellularglucosehomeostasiscellularresponsetoamyloid-betacentralnervoussystemdevelopmentcircadianregulationofgeneexpressiondetectionoftemperaturestimulusdorsalaortadevelopmentfibroblastgrowthfactorreceptorsignalingpathwayfibroblastproliferationglucosehomeostasishairfolliclemorphogenesisintracellularproteintransportnegativeregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisnegativeregulationofcellmigrationnegativeregulationoffibroblastgrowthfactorreceptorsignalingpathwaynegativeregulationofhairfollicledevelopmentnervedevelopmentneuronapoptoticprocessodontogenesisofdentin-containingtoothpositiveregulationofapoptoticsignalingpathwaypositiveregulationoffibroblastproliferationpositiveregulationofmiRNAtranscriptionpositiveregulationofodontogenesisofdentin-containingtoothpositiveregulationofproteinlocalizationtonucleusRhoproteinsignaltransduction
T-cell surface glycoprotein CD4
445
Tyrosine-protein kinase Lck
23
3.8
37
0.71
CD4LCKP01730P06239adaptiveimmuneresponsecalcium-mediatedsignalingcelladhesioncellsurfacereceptorsignalingpathwaycellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimulusdefenseresponsetoGram-negativebacteriumenzyme-linkedreceptorproteinsignalingpathwayhelperTcellenhancementofadaptiveimmuneresponseimmuneresponseinterleukin-15-mediatedsignalingpathwaymacrophagedifferentiationmaintenanceofproteinlocationincellpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofERK1andERK2cascadepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-2productionpositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmonocytedifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofTcellactivationpositiveregulationoftranscriptionDNA-templatedpositiveregulationofviralentryintohostcellregulationofcalciumiontransportregulationofTcellactivationsignaltransductionTcellactivationTcelldifferentiationTcellselectiontransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessBcellreceptorsignalingpathwaycelldifferentiationcellularzincionhomeostasisFc-gammareceptorsignalingpathwayhemopoiesisinnateimmuneresponseintracellularsignaltransductionleukocytemigrationpeptidyl-tyrosineautophosphorylationplateletactivationpositiveregulationofheterotypiccell-celladhesionpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofleukocytecell-celladhesionpositiveregulationofTcellreceptorsignalingpathwayproteinphosphorylationregulationoflymphocyteactivationreleaseofsequesteredcalciumionintocytosolresponsetoxenobioticstimulusTcellcostimulationTcellreceptorsignalingpathway
C-C motif chemokine 5
34
C-C motif chemokine 5
57
8.2
60
0.2
CCL5CCL5P30882P30882activationofphospholipaseDactivitycalciumiontransportcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwayeosinophilchemotaxisepithelialcellproliferationexocytosisGprotein-coupledreceptorsignalingpathwayinflammatoryresponseleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofcelldeathnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofmacrophageapoptoticprocessnegativeregulationofneurondeathnegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofangiogenesispositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofchemokine(C-X-Cmotif)ligand2productionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffevergenerationpositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofmacrophagechemotaxispositiveregulationofmastcellchemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofneurondifferentiationpositiveregulationofosteoclastdifferentiationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinproteinkinaseBsignalingpseudopodiumassemblyregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetocytokineresponsetointerferon-gammaresponsetotoxicsubstanceresponsetotumornecrosisfactorT-helper1celldiapedesis
Transcription factor HES-1
146
Transcription factor HES-1
117
9.9
69
0.15
HES1HES1Q14469Q14469adenohypophysisdevelopmentamacrinecelldifferentiationanterior/posteriorpatternspecificationarterymorphogenesisascendingaortamorphogenesisBMPsignalingpathwayCajal-Retziuscelldifferentiationcardiacneuralcrestcelldevelopmentinvolvedinoutflowtractmorphogenesiscelladhesioncellfatedeterminationcellmaturationcellmigrationcellmorphogenesisinvolvedinneurondifferentiationcellularresponsetofattyacidcellularresponsetointerleukin-1cellularresponsetonervegrowthfactorstimuluscellularresponsetotumornecrosisfactorcochleadevelopmentcomma-shapedbodymorphogenesiscommonbileductdevelopmentembryonichearttubemorphogenesisestablishmentofepithelialcellpolarityforebrainradialglialcelldifferentiationglomerulusvasculaturedevelopmenthindbrainmorphogenesisinnerearauditoryreceptorcelldifferentiationinnerearreceptorcellstereociliumorganizationlabyrinthinelayerbloodvesseldevelopmentlateralinhibitionliverdevelopmentlungdevelopmentmetanephricnephrontubulemorphogenesismidbraindevelopmentmidbrain-hindbrainboundarymorphogenesisnegativeregulationofamacrinecelldifferentiationnegativeregulationofcalciumionimportnegativeregulationofcellfatedeterminationnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofforebrainneurondifferentiationnegativeregulationofgeneexpressionnegativeregulationofglialcellproliferationnegativeregulationofinnerearauditoryreceptorcelldifferentiationnegativeregulationofneurondifferentiationnegativeregulationofneuronprojectiondevelopmentnegativeregulationofoligodendrocytedifferentiationnegativeregulationofpancreaticAcelldifferentiationnegativeregulationofpro-BcelldifferentiationnegativeregulationofstemcelldifferentiationnegativeregulationofstomachneuroendocrinecelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednervoussystemdevelopmentneuronalstemcellpopulationmaintenanceNotchsignalingpathwayoculomotornervedevelopmentoutflowtractmorphogenesispancreaticAcelldifferentiationpharyngealarcharterymorphogenesispositiveregulationofastrocytedifferentiationpositiveregulationofBMPsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofgeneexpressionpositiveregulationofmitoticcellcycleembryonicpositiveregulationofNotchsignalingpathwaypositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofTcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftyrosinephosphorylationofSTATproteinprotein-containingcomplexassemblyregulationofepithelialcellproliferationregulationoffatcelldifferentiationregulationofneurogenesisregulationofprotein-containingcomplexassemblyregulationofreceptorsignalingpathwayviaJAK-STATregulationofsecondaryheartfieldcardioblastproliferationregulationoftimingofneurondifferentiationregulationoftranscriptionbyRNApolymeraseIIrenalinterstitialfibroblastdevelopmentresponsetoalkaloidresponsetoorganiccycliccompoundresponsetothyroidhormoneS-shapedbodymorphogenesissmoothenedsignalingpathwaysomaticstemcellpopulationmaintenancestomachneuroendocrinecelldifferentiationTcellproliferationtelencephalondevelopmentthymusdevelopmenttrochlearnervedevelopmenturetericbudmorphogenesisvascularassociatedsmoothmusclecelldevelopmentventricularseptumdevelopmentventricularseptummorphogenesis
Histone lysine acetyltransferase CREBBP
379
Hypoxia-inducible factor 1-alpha
780
9.9
57
0.18
CBPHIF1AP45481Q16665behavioralresponsetococainecellpopulationproliferationcellularresponsetohepatocytegrowthfactorstimuluscellularresponsetoUVcellularresponsetovirusfacemorphogenesisgerm-linestemcellpopulationmaintenancehistoneacetylationhistoneglutaminemethylationlong-termmemoryN-terminalpeptidyl-lysineacetylationnegativeregulationofinterferon-betaproductionnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofviralprocesspositiveregulationofcelladhesionmoleculeproductionpositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofdendriticspinedevelopmentpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayproteinacetylationproteindestabilizationregulationoftranscriptionDNA-templatedrhythmicprocessangiogenesisaxonaltransportofmitochondrionB-1Bcellhomeostasisbonemineralizationcardiacventriclemorphogenesiscellularglucosehomeostasiscellularironionhomeostasiscellularresponsetohypoxiacellularresponsetointerleukin-1cerebralcortexdevelopmentchondrocytedifferentiationcollagenmetabolicprocessconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingdigestivetractmorphogenesisdopaminergicneurondifferentiationelastinmetabolicprocessembryonichemopoiesisembryonicplacentadevelopmentepithelialcelldifferentiationinvolvedinmammaryglandalveolusdevelopmentepithelialtomesenchymaltransitionglandularepithelialcellmaturationheartloopinghemoglobinbiosyntheticprocesshypoxia-induciblefactor-1alphasignalingpathwayinsulinsecretioninvolvedincellularresponsetoglucosestimulusintestinalepithelialcellmaturationirismorphogenesislactatemetabolicprocesslactationmesenchymalcellapoptoticprocessmusclecellcellularhomeostasisnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofgrowthnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofthymocyteapoptoticprocessnegativeregulationofTORsignalingneuralcrestcellmigrationneuralfoldelevationformationneuroblastproliferationneuronapoptoticprocessoutflowtractmorphogenesisoxygenhomeostasispositiveregulationofangiogenesispositiveregulationofautophagyofmitochondrionpositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofchemokineproductionpositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellmigrationpositiveregulationoferythrocytedifferentiationpositiveregulationofglycolyticprocesspositiveregulationofhormonebiosyntheticprocesspositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofmacroautophagypositiveregulationofmiRNAtranscriptionpositiveregulationofneuroblastproliferationpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofsignalingreceptoractivitypositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofaerobicrespirationregulationofgeneexpressionregulationofglycolyticprocessregulationofproteinneddylationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetooxidativestressregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetoironionresponsetomuscleactivityresponsetoreactiveoxygenspeciesretinavasculaturedevelopmentincamera-typeeyesignaltransductionTORsignalingvascularendothelialgrowthfactorproductionvisuallearning
Histone lysine acetyltransferase CREBBP
384
Hypoxia-inducible factor 1-alpha
780
8.8
59
0.19
CBPHIF1AP45481Q16665behavioralresponsetococainecellpopulationproliferationcellularresponsetohepatocytegrowthfactorstimuluscellularresponsetoUVcellularresponsetovirusfacemorphogenesisgerm-linestemcellpopulationmaintenancehistoneacetylationhistoneglutaminemethylationlong-termmemoryN-terminalpeptidyl-lysineacetylationnegativeregulationofinterferon-betaproductionnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofviralprocesspositiveregulationofcelladhesionmoleculeproductionpositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofdendriticspinedevelopmentpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayproteinacetylationproteindestabilizationregulationoftranscriptionDNA-templatedrhythmicprocessangiogenesisaxonaltransportofmitochondrionB-1Bcellhomeostasisbonemineralizationcardiacventriclemorphogenesiscellularglucosehomeostasiscellularironionhomeostasiscellularresponsetohypoxiacellularresponsetointerleukin-1cerebralcortexdevelopmentchondrocytedifferentiationcollagenmetabolicprocessconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingdigestivetractmorphogenesisdopaminergicneurondifferentiationelastinmetabolicprocessembryonichemopoiesisembryonicplacentadevelopmentepithelialcelldifferentiationinvolvedinmammaryglandalveolusdevelopmentepithelialtomesenchymaltransitionglandularepithelialcellmaturationheartloopinghemoglobinbiosyntheticprocesshypoxia-induciblefactor-1alphasignalingpathwayinsulinsecretioninvolvedincellularresponsetoglucosestimulusintestinalepithelialcellmaturationirismorphogenesislactatemetabolicprocesslactationmesenchymalcellapoptoticprocessmusclecellcellularhomeostasisnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofgrowthnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofthymocyteapoptoticprocessnegativeregulationofTORsignalingneuralcrestcellmigrationneuralfoldelevationformationneuroblastproliferationneuronapoptoticprocessoutflowtractmorphogenesisoxygenhomeostasispositiveregulationofangiogenesispositiveregulationofautophagyofmitochondrionpositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofchemokineproductionpositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellmigrationpositiveregulationoferythrocytedifferentiationpositiveregulationofglycolyticprocesspositiveregulationofhormonebiosyntheticprocesspositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofmacroautophagypositiveregulationofmiRNAtranscriptionpositiveregulationofneuroblastproliferationpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofsignalingreceptoractivitypositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofaerobicrespirationregulationofgeneexpressionregulationofglycolyticprocessregulationofproteinneddylationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetooxidativestressregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetoironionresponsetomuscleactivityresponsetoreactiveoxygenspeciesretinavasculaturedevelopmentincamera-typeeyesignaltransductionTORsignalingvascularendothelialgrowthfactorproductionvisuallearning
C-C motif chemokine 5
57
C-C motif chemokine 5
34
8.3
70
0.17
CCL5CCL5P13501P13501activationofphospholipaseDactivitycalciumiontransportcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetoviruschemokine-mediatedsignalingpathwaychemotaxisdendriticcellchemotaxiseosinophilchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwayinflammatoryresponseleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofinnateimmuneresponsepositiveregulationofmacrophagechemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftranslationalinitiationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofviralgenomereplicationproteinkinaseBsignalingregulationofchronicinflammatoryresponseregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetotoxicsubstanceresponsetovirus
Transforming growth factor beta-1 proprotein
355
Transforming growth factor beta-1 proprotein
387
8.3
91
0.13
TGFB1TGFB1P01137P01137aorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaycellmigrationcell-celljunctionorganizationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluschondrocytedifferentiationcommon-partnerSMADproteinphosphorylationconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingembryonicliverdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayheartdevelopmentheartvalvemorphogenesishematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphnodedevelopmentmacrophagederivedfoamcelldifferentiationMAPKcascademembraneproteinintracellulardomainproteolysisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofcytolysisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixdisassemblynegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofmacrophagecytokineproductionnegativeregulationofmiRNAmaturationnegativeregulationofmiRNAtranscriptionnegativeregulationofmiRNA-mediatedgenesilencingnegativeregulationofmyoblastdifferentiationnegativeregulationofproteinlocalizationtoplasmamembranenegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationoftranscriptionDNA-templatedneuraltubeclosureneuraltubedevelopmentossificationinvolvedinboneremodelingpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixassemblypositiveregulationoffibroblastmigrationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationofSMADproteinsignaltransductionpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularpermeabilityproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofbindingregulationofbloodvesselremodelingregulationofcellmigrationregulationofcellpopulationproliferationregulationofDNAbindingregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
Defensin alpha 5
65
Defensin alpha 5
92
8.8
69
0.16
DEF5DEF5Q01523Q01523antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismpositiveregulationofinterleukin-8productionpositiveregulationofmembranepermeabilityproteinhomotetramerization
Cardiac phospholamban
41
Cardiac phospholamban
41
8.9
64
0.18
PPLAPPLAP26678P26678adenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocessbloodcirculationcardiacmuscletissuedevelopmentmusclecellcellularhomeostasisnegativeregulationofATP-dependentactivitynegativeregulationofATPase-coupledcalciumtransmembranetransporteractivitynegativeregulationofcalciumionbindingnegativeregulationofcalciumionimportnegativeregulationofcalciumionimportintosarcoplasmicreticulumnegativeregulationofcalciumiontransmembranetransporteractivitynegativeregulationofcalciumiontransportnegativeregulationofcatalyticactivitynegativeregulationofheartrateNotchsignalingpathwayregulationofATPase-coupledcalciumtransmembranetransporteractivityregulationofcalciumiontransportregulationofcardiacmusclecellcontractionregulationofcardiacmusclecellmembranepotentialregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofcytosoliccalciumionconcentrationregulationofheartcontractionregulationofrelaxationofcardiacmuscleregulationofryanodine-sensitivecalcium-releasechannelactivityregulationoftheforceofheartcontractionregulationoftheforceofheartcontractionbycardiacconductionrelaxationofcardiacmuscle
Histone lysine acetyltransferase CREBBP
429
Hypoxia-inducible factor 1-alpha
780
8.6
61
0.19
CBPHIF1AP45481Q16665behavioralresponsetococainecellpopulationproliferationcellularresponsetohepatocytegrowthfactorstimuluscellularresponsetoUVcellularresponsetovirusfacemorphogenesisgerm-linestemcellpopulationmaintenancehistoneacetylationhistoneglutaminemethylationlong-termmemoryN-terminalpeptidyl-lysineacetylationnegativeregulationofinterferon-betaproductionnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofviralprocesspositiveregulationofcelladhesionmoleculeproductionpositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofdendriticspinedevelopmentpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayproteinacetylationproteindestabilizationregulationoftranscriptionDNA-templatedrhythmicprocessangiogenesisaxonaltransportofmitochondrionB-1Bcellhomeostasisbonemineralizationcardiacventriclemorphogenesiscellularglucosehomeostasiscellularironionhomeostasiscellularresponsetohypoxiacellularresponsetointerleukin-1cerebralcortexdevelopmentchondrocytedifferentiationcollagenmetabolicprocessconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingdigestivetractmorphogenesisdopaminergicneurondifferentiationelastinmetabolicprocessembryonichemopoiesisembryonicplacentadevelopmentepithelialcelldifferentiationinvolvedinmammaryglandalveolusdevelopmentepithelialtomesenchymaltransitionglandularepithelialcellmaturationheartloopinghemoglobinbiosyntheticprocesshypoxia-induciblefactor-1alphasignalingpathwayinsulinsecretioninvolvedincellularresponsetoglucosestimulusintestinalepithelialcellmaturationirismorphogenesislactatemetabolicprocesslactationmesenchymalcellapoptoticprocessmusclecellcellularhomeostasisnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofgrowthnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofthymocyteapoptoticprocessnegativeregulationofTORsignalingneuralcrestcellmigrationneuralfoldelevationformationneuroblastproliferationneuronapoptoticprocessoutflowtractmorphogenesisoxygenhomeostasispositiveregulationofangiogenesispositiveregulationofautophagyofmitochondrionpositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofchemokineproductionpositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellmigrationpositiveregulationoferythrocytedifferentiationpositiveregulationofglycolyticprocesspositiveregulationofhormonebiosyntheticprocesspositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofmacroautophagypositiveregulationofmiRNAtranscriptionpositiveregulationofneuroblastproliferationpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofsignalingreceptoractivitypositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofaerobicrespirationregulationofgeneexpressionregulationofglycolyticprocessregulationofproteinneddylationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetooxidativestressregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetoironionresponsetomuscleactivityresponsetoreactiveoxygenspeciesretinavasculaturedevelopmentincamera-typeeyesignaltransductionTORsignalingvascularendothelialgrowthfactorproductionvisuallearning
Insulin
95
Insulin
31
8.9
nan
nan
INSINSQ5EEX2Q5EEX2activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
Fibroblast growth factor receptor substrate 3
91
ALK tyrosine kinase receptor
1579
8.9
58
0.19
FRS3ALKO43559Q9UM73fibroblastgrowthfactorreceptorsignalingpathwaysignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathwayadultbehaviorenergyhomeostasishippocampusdevelopmentnegativeregulationoflipidcatabolicprocessneurondevelopmentpeptidyl-tyrosineautophosphorylationphosphorylationpositiveregulationofdendritedevelopmentpositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofNF-kappaBtranscriptionfactoractivityproteinautophosphorylationregulationofapoptoticprocessregulationofcellpopulationproliferationregulationofdopaminereceptorsignalingpathwayregulationofneurondifferentiationresponsetoenvironmentalenrichmentswimmingbehavior
Insulin-like 3
120
Insulin-like 3
46
8.9
56
0.2
INSL3INSL3P51460P51460adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaycell-cellsignalingmalegonaddevelopmentnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationoocytematurationpositiveregulationofcAMP-mediatedsignalingpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofwoundhealingspermatogenesis
Insulin-like 3
115
Insulin-like 3
46
9.9
59
0.17
INSL3INSL3P51460P51460adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaycell-cellsignalingmalegonaddevelopmentnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationoocytematurationpositiveregulationofcAMP-mediatedsignalingpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofwoundhealingspermatogenesis
Protegrin-3
136
Protegrin-3
145
7.4
43
0.32
PG3PG3P32196P32196antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponse
Protegrin-3
145
Protegrin-3
143
9.5
45
0.23
PG3PG3P32196P32196antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponse
Relaxin-3
35
Relaxin-3
128
8.7
55
0.21
REL3REL3Q8WXF3Q8WXF3
Histone lysine acetyltransferase CREBBP
366
Hypoxia-inducible factor 1-alpha
780
9.1
64
0.17
CBPHIF1AP45481Q16665behavioralresponsetococainecellpopulationproliferationcellularresponsetohepatocytegrowthfactorstimuluscellularresponsetoUVcellularresponsetovirusfacemorphogenesisgerm-linestemcellpopulationmaintenancehistoneacetylationhistoneglutaminemethylationlong-termmemoryN-terminalpeptidyl-lysineacetylationnegativeregulationofinterferon-betaproductionnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofviralprocesspositiveregulationofcelladhesionmoleculeproductionpositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofdendriticspinedevelopmentpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayproteinacetylationproteindestabilizationregulationoftranscriptionDNA-templatedrhythmicprocessangiogenesisaxonaltransportofmitochondrionB-1Bcellhomeostasisbonemineralizationcardiacventriclemorphogenesiscellularglucosehomeostasiscellularironionhomeostasiscellularresponsetohypoxiacellularresponsetointerleukin-1cerebralcortexdevelopmentchondrocytedifferentiationcollagenmetabolicprocessconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingdigestivetractmorphogenesisdopaminergicneurondifferentiationelastinmetabolicprocessembryonichemopoiesisembryonicplacentadevelopmentepithelialcelldifferentiationinvolvedinmammaryglandalveolusdevelopmentepithelialtomesenchymaltransitionglandularepithelialcellmaturationheartloopinghemoglobinbiosyntheticprocesshypoxia-induciblefactor-1alphasignalingpathwayinsulinsecretioninvolvedincellularresponsetoglucosestimulusintestinalepithelialcellmaturationirismorphogenesislactatemetabolicprocesslactationmesenchymalcellapoptoticprocessmusclecellcellularhomeostasisnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofgrowthnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofthymocyteapoptoticprocessnegativeregulationofTORsignalingneuralcrestcellmigrationneuralfoldelevationformationneuroblastproliferationneuronapoptoticprocessoutflowtractmorphogenesisoxygenhomeostasispositiveregulationofangiogenesispositiveregulationofautophagyofmitochondrionpositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofchemokineproductionpositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellmigrationpositiveregulationoferythrocytedifferentiationpositiveregulationofglycolyticprocesspositiveregulationofhormonebiosyntheticprocesspositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofmacroautophagypositiveregulationofmiRNAtranscriptionpositiveregulationofneuroblastproliferationpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofsignalingreceptoractivitypositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofaerobicrespirationregulationofgeneexpressionregulationofglycolyticprocessregulationofproteinneddylationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetooxidativestressregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetoironionresponsetomuscleactivityresponsetoreactiveoxygenspeciesretinavasculaturedevelopmentincamera-typeeyesignaltransductionTORsignalingvascularendothelialgrowthfactorproductionvisuallearning
Insulin
100
Insulin
31
9.1
nan
nan
INSINSQ5EEX2Q5EEX2activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
Trefoil factor 3
57
Trefoil factor 3
42
8.9
77
0.15
TFF3TFF3Q07654Q07654maintenanceofgastrointestinalepitheliumregulationofglucosemetabolicprocess
C-C motif chemokine 5
57
C-C motif chemokine 5
57
8.7
47
0.24
CCL5CCL5P30882P30882activationofphospholipaseDactivitycalciumiontransportcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwayeosinophilchemotaxisepithelialcellproliferationexocytosisGprotein-coupledreceptorsignalingpathwayinflammatoryresponseleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofcelldeathnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofmacrophageapoptoticprocessnegativeregulationofneurondeathnegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofangiogenesispositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofchemokine(C-X-Cmotif)ligand2productionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffevergenerationpositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofmacrophagechemotaxispositiveregulationofmastcellchemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofneurondifferentiationpositiveregulationofosteoclastdifferentiationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinproteinkinaseBsignalingpseudopodiumassemblyregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetocytokineresponsetointerferon-gammaresponsetotoxicsubstanceresponsetotumornecrosisfactorT-helper1celldiapedesis
Insulin-like 3
120
Insulin-like 3
34
8.7
56
0.2
INSL3INSL3P51460P51460adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaycell-cellsignalingmalegonaddevelopmentnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationoocytematurationpositiveregulationofcAMP-mediatedsignalingpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofwoundhealingspermatogenesis
Defensin alpha 5
72
Defensin alpha 5
65
9.9
55
0.18
DEF5DEF5Q01523Q01523antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismpositiveregulationofinterleukin-8productionpositiveregulationofmembranepermeabilityproteinhomotetramerization
Protegrin-3
145
Protegrin-3
145
6.5
50
0.31
PG3PG3P32196P32196antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponse
Trefoil factor 3
57
Trefoil factor 3
57
8.7
87
0.13
TFF3TFF3Q07654Q07654maintenanceofgastrointestinalepitheliumregulationofglucosemetabolicprocess
T-cell surface glycoprotein CD8 alpha chain
215
Tyrosine-protein kinase Lck
23
3.9
40
0.65
CD8ALCKP01732P06239adaptiveimmuneresponseantigenprocessingandpresentationcellsurfacereceptorsignalingpathwaycytotoxicTcelldifferentiationimmuneresponseTcellactivationTcellmediatedimmunityTcellreceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessBcellreceptorsignalingpathwaycelldifferentiationcellularzincionhomeostasisFc-gammareceptorsignalingpathwayhemopoiesisinnateimmuneresponseintracellularsignaltransductionleukocytemigrationpeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationplateletactivationpositiveregulationofheterotypiccell-celladhesionpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofleukocytecell-celladhesionpositiveregulationofTcellactivationpositiveregulationofTcellreceptorsignalingpathwayproteinphosphorylationregulationoflymphocyteactivationreleaseofsequesteredcalciumionintocytosolresponsetoxenobioticstimulusTcellcostimulationTcelldifferentiation
T-cell surface glycoprotein CD8 alpha chain
217
Tyrosine-protein kinase Lck
20
3.9
38
0.68
CD8ALCKP01732P06239adaptiveimmuneresponseantigenprocessingandpresentationcellsurfacereceptorsignalingpathwaycytotoxicTcelldifferentiationimmuneresponseTcellactivationTcellmediatedimmunityTcellreceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessBcellreceptorsignalingpathwaycelldifferentiationcellularzincionhomeostasisFc-gammareceptorsignalingpathwayhemopoiesisinnateimmuneresponseintracellularsignaltransductionleukocytemigrationpeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationplateletactivationpositiveregulationofheterotypiccell-celladhesionpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofleukocytecell-celladhesionpositiveregulationofTcellactivationpositiveregulationofTcellreceptorsignalingpathwayproteinphosphorylationregulationoflymphocyteactivationreleaseofsequesteredcalciumionintocytosolresponsetoxenobioticstimulusTcellcostimulationTcelldifferentiation
Insulin
100
Insulin
43
9.8
47
0.22
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
Suppressor of cytokine signaling 3
193
Elongin-C
112
8.6
nan
nan
SOCS3ELOCO35718P83940branchinginvolvedinlabyrinthinelayermorphogenesiscelldifferentiationcellularresponsetointerleukin-17cellularresponsetoleukemiainhibitoryfactorintracellularsignaltransductionnegativeregulationofapoptoticprocessnegativeregulationofinflammatoryresponsenegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofreceptorsignalingpathwayviaJAK-STATnegativeregulationofsignaltransductionnegativeregulationoftyrosinephosphorylationofSTATproteinphosphatidylinositolphosphatebiosyntheticprocessplacentabloodvesseldevelopmentpositiveregulationofcelldifferentiationproteinubiquitinationreceptorsignalingpathwayviaJAK-STATregulationofgrowthregulationofproteinphosphorylationsignaltransductionpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromotertranscriptioninitiationfromRNApolymeraseIIpromoterubiquitin-dependentproteincatabolicprocess
Protein S100-A14
62
Protein S100-A14
4
8.6
20
0.58
S10AES10AEQ9HCY8Q9HCY8apoptoticprocesscalciumionhomeostasisdefenseresponsetobacteriumpositiveregulationofgranulocytechemotaxispositiveregulationofmonocytechemotaxisresponsetolipopolysaccharidetoll-likereceptor4signalingpathway
Superoxide dismutase [Cu-Zn]
147
Superoxide dismutase [Cu-Zn]
147
8.6
97
0.12
SODCSODCP00441P00441aginganterogradeaxonaltransportapoptoticprocessauditoryreceptorcellstereociliumorganizationcellularironionhomeostasiscellularresponsetoATPcellularresponsetocadmiumioncellularresponsetopotassiumionectopicgermcellprogrammedcelldeathembryoimplantationglutathionemetabolicprocessheartcontractionhydrogenperoxidebiosyntheticprocesslocomotorybehaviormusclecellcellularhomeostasismyeloidcellhomeostasisnegativeregulationofcholesterolbiosyntheticprocessnegativeregulationofdevelopmentalprocessnegativeregulationofinflammatoryresponsenegativeregulationofneuronapoptoticprocessnegativeregulationofreproductiveprocessneurofilamentcytoskeletonorganizationovarianfollicledevelopmentperipheralnervoussystemmyelinmaintenanceplacentadevelopmentpositiveregulationofapoptoticprocesspositiveregulationofcatalyticactivitypositiveregulationofcytokineproductionpositiveregulationofMAPKcascadepositiveregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaypositiveregulationofphagocytosispositiveregulationofsuperoxideaniongenerationreactiveoxygenspeciesmetabolicprocessregulationofbloodpressureregulationofGTPaseactivityregulationofmitochondrialmembranepotentialregulationofmulticellularorganismgrowthregulationoforgangrowthregulationofproteinkinaseactivityregulationofTcelldifferentiationinthymusrelaxationofvascularassociatedsmoothmuscleremovalofsuperoxideradicalsresponsetoamphetamineresponsetoantibioticresponsetoantipsychoticdrugresponsetoaxoninjuryresponsetocarbonmonoxideresponsetocopperionresponsetoethanolresponsetoheatresponsetohydrogenperoxideresponsetonutrientlevelsresponsetoorganicsubstanceresponsetosuperoxideresponsetoxenobioticstimulusretinahomeostasisretrogradeaxonaltransportsensoryperceptionofsoundspermatogenesissuperoxideaniongenerationsuperoxidemetabolicprocessthymusdevelopmenttransmissionofnerveimpulse
Beta-nerve growth factor
189
Beta-nerve growth factor
189
8.8
80
0.14
NGFNGFP01139P01139activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessadultlocomotorybehavioraxonextensioncircadianrhythmextrinsicapoptoticsignalingpathwayinabsenceofligandextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsmemorymodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnegativeregulationoftypeBpancreaticcellapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwayneuronapoptoticprocessneuronprojectiondevelopmentneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofaxonextensionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofcollateralsproutingpositiveregulationofDNAbindingpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofneurondifferentiationpositiveregulationofneuronmaturationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofneurotrophinTRKreceptorsignalingpathwaypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinautophosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinphosphorylationpositiveregulationofproteinubiquitinationpositiveregulationofRasproteinsignaltransductionpositiveregulationofstemcellproliferationproteinphosphorylationregulationofneurondifferentiationregulationofneurotransmittersecretionregulationofreleaseofsequesteredcalciumionintocytosolsensoryperceptionofpaintransmembranereceptorproteintyrosinekinasesignalingpathway
DNA fragmentation factor subunit beta
10
DNA fragmentation factor subunit alpha
78
5.2
66
0.29
DFFBDFFAO54788O54786apoptoticchromosomecondensationapoptoticDNAfragmentationDNAcatabolicprocessnegativeregulationofapoptoticDNAfragmentationchaperone-mediatedproteinfoldingnegativeregulationofdeoxyribonucleaseactivitynegativeregulationofexecutionphaseofapoptosispositiveregulationofapoptoticprocessregulationofapoptoticprocessthymocyteapoptoticprocess
Cytoplasmic dynein 1 intermediate chain 2
284
Cytoplasmic dynein 1 intermediate chain 2
284
9.2
65
0.17
DC1I2DC1I2Q13409Q13409microtubule-basedmovementtransportalongmicrotubule
Protein S100-A11
10
Protein S100-A11
10
9.4
72
0.15
S10ABS10ABP24480P24480regulationofcellpopulationproliferation
Protegrin-3
136
Protegrin-3
136
7.7
39
0.33
PG3PG3P32196P32196antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponse
Receptor tyrosine-protein kinase erbB-2
642
Epidermal growth factor receptor
636
9.5
15
0.7
ERBB2EGFRP04626P00533cellsurfacereceptorsignalingpathwaycellularresponsetoepidermalgrowthfactorstimuluscellularresponsetogrowthfactorstimulusenzyme-linkedreceptorproteinsignalingpathwayERBB2-EGFRsignalingpathwayERBB2-ERBB3signalingpathwayERBB2-ERBB4signalingpathwayheartdevelopmentimmatureTcellproliferationinthymusintracellularsignaltransductionmotorneuronaxonguidancemyelinationnegativeregulationofimmatureTcellproliferationinthymusneuromuscularjunctiondevelopmentneurondifferentiationoligodendrocytedifferentiationpeptidyl-tyrosinephosphorylationperipheralnervoussystemdevelopmentphosphatidylinositol3-kinasesignalingpositiveregulationofcelladhesionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofGTPaseactivitypositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofproteinphosphorylationpositiveregulationofproteintargetingtomembranepositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranslationproteinautophosphorylationproteinphosphorylationregulationofangiogenesisregulationofERK1andERK2cascaderegulationofmicrotubule-basedprocesssignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathwaywoundhealingactivationofphospholipaseCactivitycelldifferentiationcellmorphogenesiscell-celladhesioncellularresponsetoaminoacidstimuluscellularresponsetocadmiumioncellularresponsetoestradiolstimuluscellularresponsetoreactiveoxygenspeciescerebralcortexcellmigrationdigestivetractmorphogenesisembryonicplacentadevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialcellproliferationeyeliddevelopmentincamera-typeeyehairfollicledevelopmentlearningormemorymorphogenesisofanepithelialfoldnegativeregulationofapoptoticprocessnegativeregulationofcardiocytedifferentiationnegativeregulationofepidermalgrowthfactorreceptorsignalingpathwaynegativeregulationofproteincatabolicprocessossificationpeptidyl-tyrosineautophosphorylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofDNArepairpositiveregulationofDNAreplicationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofmiRNAmaturationpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinkinaseCactivitypositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedproteininsertionintomembraneregulationofJNKcascaderegulationofnitric-oxidesynthaseactivityregulationofpeptidyl-tyrosinephosphorylationregulationofphosphatidylinositol3-kinasesignalingresponsetoUV-Asalivaryglandmorphogenesis
C-C motif chemokine 5
34
C-C motif chemokine 5
33
9.4
72
0.15
CCL5CCL5P30882P30882activationofphospholipaseDactivitycalciumiontransportcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwayeosinophilchemotaxisepithelialcellproliferationexocytosisGprotein-coupledreceptorsignalingpathwayinflammatoryresponseleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofcelldeathnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofmacrophageapoptoticprocessnegativeregulationofneurondeathnegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofangiogenesispositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofchemokine(C-X-Cmotif)ligand2productionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffevergenerationpositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofmacrophagechemotaxispositiveregulationofmastcellchemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofneurondifferentiationpositiveregulationofosteoclastdifferentiationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinproteinkinaseBsignalingpseudopodiumassemblyregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetocytokineresponsetointerferon-gammaresponsetotoxicsubstanceresponsetotumornecrosisfactorT-helper1celldiapedesis
C-C motif chemokine 4
74
C-C motif chemokine 4
34
9.8
77
0.13
CCL4CCL4P13236P13236celladhesioncell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwayeosinophilchemotaxisestablishmentormaintenanceofcellpolarityGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponselymphocytechemotaxismonocytechemotaxisnegativeregulationbyhostofviraltranscriptionneutrophilchemotaxispositiveregulationofcalciumiontransportpositiveregulationofcalcium-mediatedsignalingpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofnaturalkillercellchemotaxisresponsetotoxicsubstanceresponsetovirussignaltransduction
Insulin-like growth factor 2 receptor variant
1521
Insulin-like growth factor II
75
9.3
64
0.17
Q59EZ3IGF2Q59EZ3P01344lysosomaltransportanimalorganmorphogenesisembryonicplacentadevelopmentembryonicplacentamorphogenesisexocrinepancreasdevelopmentglucosemetabolicprocessinuteroembryonicdevelopmentinsulinreceptorsignalingpathwayinsulinreceptorsignalingpathwayviaphosphatidylinositol3-kinasenegativeregulationofmusclecelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIosteoblastdifferentiationpositiveregulationofactivatedTcellproliferationpositiveregulationofcatalyticactivitypositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofglycogen(starch)synthaseactivitypositiveregulationofglycogenbiosyntheticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofmulticellularorganismgrowthpositiveregulationoforgangrowthpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofskeletalmuscletissuegrowthpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularendothelialcellproliferationregulationofgeneexpressionbygenomicimprintingregulationofhistonemodificationregulationofmusclecelldifferentiationregulationoftranscriptionDNA-templatedspongiotrophoblastcellproliferationstriatedmusclecelldifferentiation
Relaxin-3
35
Relaxin-3
133
9.8
58
0.18
REL3REL3Q8WXF3Q8WXF3
Oxytocin-neurophysin 1
65
Oxytocin-neurophysin 1
65
9.3
102
0.11
NEU1NEU1P01175P01175positiveregulationofcold-inducedthermogenesisresponsetoestrogenresponsetoexternalbioticstimulusresponsetofoodresponsetomechanicalstimulus
C-C motif chemokine 2
34
C-C motif chemokine 2
35
9.4
76
0.14
CCL2CCL2P13500P13500angiogenesisanimalorganmorphogenesisastrocytecellmigrationcelladhesioncellsurfacereceptorsignalingpathwaycellularhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetolipopolysaccharidecellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytokine-mediatedsignalingpathwaycytoskeletonorganizationeosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerhelperTcellextravasationhumoralimmuneresponseinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofglialcellapoptoticprocessnegativeregulationofnaturalkillercellchemotaxisnegativeregulationofneuronapoptoticprocessnegativeregulationofvascularendothelialcellproliferationneutrophilchemotaxispositiveregulationofapoptoticcellclearancepositiveregulationofcalciumionimportpositiveregulationofendothelialcellapoptoticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofNMDAglutamatereceptoractivitypositiveregulationofsynaptictransmissionglutamatergicpositiveregulationofTcellactivationproteinkinaseBsignalingproteinphosphorylationreceptorsignalingpathwayviaJAK-STATregulationofcellshaperesponsetobacteriumsensoryperceptionofpainsignaltransductionviralgenomereplication
Cytoplasmic dynein 1 intermediate chain 2
69
Cytoplasmic dynein 1 intermediate chain 2
284
9.7
70
0.15
DC1I2DC1I2Q13409Q13409microtubule-basedmovementtransportalongmicrotubule
Insulin
90
Insulin
43
9.8
52
0.2
INSINSP01317P01317estradiolsecretionfeedingbehaviorglucoseimportinresponsetoinsulinstimulusglucosemetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofappetitenegativeregulationoflactationnegativeregulationoflipidcatabolicprocesspositiveregulationofbloodcirculationpositiveregulationofcellmaturationpositiveregulationofgeneexpressionpositiveregulationofinsulinsecretionpositiveregulationoflactationpositiveregulationofmammaryglandepithelialcellproliferationpositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRhoproteinsignaltransductionproteinsecretionresponsetobutyrateresponsetofoodresponsetoglucoseresponsetogrowthhormoneresponsetoheatresponsetoL-arginineresponsetonutrientlevels
Cardiac phospholamban
46
Cardiac phospholamban
41
9.3
58
0.19
PPLAPPLAP26678P26678adenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocessbloodcirculationcardiacmuscletissuedevelopmentmusclecellcellularhomeostasisnegativeregulationofATP-dependentactivitynegativeregulationofATPase-coupledcalciumtransmembranetransporteractivitynegativeregulationofcalciumionbindingnegativeregulationofcalciumionimportnegativeregulationofcalciumionimportintosarcoplasmicreticulumnegativeregulationofcalciumiontransmembranetransporteractivitynegativeregulationofcalciumiontransportnegativeregulationofcatalyticactivitynegativeregulationofheartrateNotchsignalingpathwayregulationofATPase-coupledcalciumtransmembranetransporteractivityregulationofcalciumiontransportregulationofcardiacmusclecellcontractionregulationofcardiacmusclecellmembranepotentialregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofcytosoliccalciumionconcentrationregulationofheartcontractionregulationofrelaxationofcardiacmuscleregulationofryanodine-sensitivecalcium-releasechannelactivityregulationoftheforceofheartcontractionregulationoftheforceofheartcontractionbycardiacconductionrelaxationofcardiacmuscle
Cytoplasmic dynein 1 intermediate chain 2
284
Cytoplasmic dynein 1 intermediate chain 2
212
9.9
71
0.14
DC1I2DC1I2Q13409Q13409microtubule-basedmovementtransportalongmicrotubule
Protein S100-A11
91
Protein S100-A11
13
9.2
71
0.15
S10ABS10ABP31949P31949negativeregulationofcellpopulationproliferationnegativeregulationofDNAreplicationpositiveregulationofsmoothmusclecellmigrationsignaltransduction
Trefoil factor 3
42
Trefoil factor 3
42
9.2
69
0.16
TFF3TFF3Q07654Q07654maintenanceofgastrointestinalepitheliumregulationofglucosemetabolicprocess
Microtubule-associated protein RP/EB family member 1
228
Microtubule-associated protein RP/EB family member 1
228
9.8
68
0.15
MARE1MARE1Q61166Q61166attachmentofmitoticspindlemicrotubulestokinetochorecelldivisioncellmigrationestablishmentofmitoticspindleorientationmicrotubulebundleformationmicrotubulepolymerizationnegativeregulationofmicrotubulepolymerizationnon-motileciliumassemblypositiveregulationofmicrotubuleplus-endbindingpositiveregulationofmicrotubulepolymerizationproteinlocalizationtoastralmicrotubuleproteinlocalizationtocentrosomeproteinlocalizationtomicrotubuleproteinlocalizationtomicrotubuleplus-endregulationofmicrotubulepolymerizationordepolymerizationspindleassembly
cGMP-dependent protein kinase 1
43
cGMP-dependent protein kinase 1
43
9.7
22
0.47
1
✔KGP1KGP1Q13976Q13976actincytoskeletonorganizationcGMP-mediatedsignalingdendritedevelopmentforebraindevelopmentnegativeregulationofplateletaggregationnegativeregulationofvascularassociatedsmoothmusclecellmigrationnegativeregulationofvascularassociatedsmoothmusclecellproliferationneuronmigrationproteinphosphorylationregulationofGTPaseactivityrelaxationofvascularassociatedsmoothmusclesignaltransduction
Stromal cell-derived factor 1
65
Stromal cell-derived factor 1
32
9.5
68
0.16
SDF1SDF1P48061P48061adultlocomotorybehavioranimalorganregenerationantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideaxonguidancebloodcirculationcelladhesioncellchemotaxiscellularcalciumionhomeostasiscellularresponsetochemokinechemokine(C-X-Cmotif)ligand12signalingpathwaychemokine-mediatedsignalingpathwaychemotaxisdefenseresponsedetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainGprotein-coupledreceptorsignalingpathwayimmuneresponseinductionofpositivechemotaxisintegrinactivationkillingofcellsofanotherorganismnegativeregulationofdendriticcellapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofleukocytetetheringorrollingneuronmigrationpositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofcalciumionimportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofdopaminesecretionpositiveregulationofendothelialcellproliferationpositiveregulationofmonocytechemotaxispositiveregulationofneurondifferentiationpositiveregulationofTcellmigrationregulationofactinpolymerizationordepolymerizationresponsetoheatresponsetohypoxiaresponsetopeptidehormoneresponsetoradiationresponsetoultrasoundresponsetovirussignaltransductionTcellchemotaxistelencephaloncellmigration
Stromal cell-derived factor 1
65
Stromal cell-derived factor 1
71
9.4
78
0.14
SDF1SDF1P48061P48061adultlocomotorybehavioranimalorganregenerationantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideaxonguidancebloodcirculationcelladhesioncellchemotaxiscellularcalciumionhomeostasiscellularresponsetochemokinechemokine(C-X-Cmotif)ligand12signalingpathwaychemokine-mediatedsignalingpathwaychemotaxisdefenseresponsedetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainGprotein-coupledreceptorsignalingpathwayimmuneresponseinductionofpositivechemotaxisintegrinactivationkillingofcellsofanotherorganismnegativeregulationofdendriticcellapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofleukocytetetheringorrollingneuronmigrationpositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofcalciumionimportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofdopaminesecretionpositiveregulationofendothelialcellproliferationpositiveregulationofmonocytechemotaxispositiveregulationofneurondifferentiationpositiveregulationofTcellmigrationregulationofactinpolymerizationordepolymerizationresponsetoheatresponsetohypoxiaresponsetopeptidehormoneresponsetoradiationresponsetoultrasoundresponsetovirussignaltransductionTcellchemotaxistelencephaloncellmigration
Pancreatic trypsin inhibitor
73
Pancreatic trypsin inhibitor
73
9.2
nan
nan
BPT1BPT1P00974P00974negativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Insulin
95
Insulin
43
9.5
51
0.21
INSINSP01317P01317estradiolsecretionfeedingbehaviorglucoseimportinresponsetoinsulinstimulusglucosemetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofappetitenegativeregulationoflactationnegativeregulationoflipidcatabolicprocesspositiveregulationofbloodcirculationpositiveregulationofcellmaturationpositiveregulationofgeneexpressionpositiveregulationofinsulinsecretionpositiveregulationoflactationpositiveregulationofmammaryglandepithelialcellproliferationpositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRhoproteinsignaltransductionproteinsecretionresponsetobutyrateresponsetofoodresponsetoglucoseresponsetogrowthhormoneresponsetoheatresponsetoL-arginineresponsetonutrientlevels
Uteroglobin
24
Uteroglobin
24
7.4
32
0.42
UTERUTERP17559P17559negativeregulationofinterferon-gammaproductionnegativeregulationofinterleukin-13productionnegativeregulationofinterleukin-4productionnegativeregulationofinterleukin-5productionnegativeregulationofTcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIregulationofinflammatoryresponseregulationofmRNAstabilityresponsetocytokineresponsetofibroblastgrowthfactorresponsetoglucocorticoidresponsetolipopolysaccharideresponsetoorganicsubstanceresponsetoozoneresponsetosilicondioxideresponsetoxenobioticstimulussignaltransductionTcellproliferation
Stromal cell-derived factor 1
65
Stromal cell-derived factor 1
55
9.9
68
0.15
SDF1SDF1P48061P48061adultlocomotorybehavioranimalorganregenerationantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideaxonguidancebloodcirculationcelladhesioncellchemotaxiscellularcalciumionhomeostasiscellularresponsetochemokinechemokine(C-X-Cmotif)ligand12signalingpathwaychemokine-mediatedsignalingpathwaychemotaxisdefenseresponsedetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainGprotein-coupledreceptorsignalingpathwayimmuneresponseinductionofpositivechemotaxisintegrinactivationkillingofcellsofanotherorganismnegativeregulationofdendriticcellapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofleukocytetetheringorrollingneuronmigrationpositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofcalciumionimportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofdopaminesecretionpositiveregulationofendothelialcellproliferationpositiveregulationofmonocytechemotaxispositiveregulationofneurondifferentiationpositiveregulationofTcellmigrationregulationofactinpolymerizationordepolymerizationresponsetoheatresponsetohypoxiaresponsetopeptidehormoneresponsetoradiationresponsetoultrasoundresponsetovirussignaltransductionTcellchemotaxistelencephaloncellmigration
Oxytocin-neurophysin 1
105
Oxytocin-neurophysin 1
105
9.5
92
0.11
NEU1NEU1P01175P01175positiveregulationofcold-inducedthermogenesisresponsetoestrogenresponsetoexternalbioticstimulusresponsetofoodresponsetomechanicalstimulus
Stromal cell-derived factor 1
32
Stromal cell-derived factor 1
265
10.0
73
0.14
SDF1SDF1P48061P48061adultlocomotorybehavioranimalorganregenerationantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideaxonguidancebloodcirculationcelladhesioncellchemotaxiscellularcalciumionhomeostasiscellularresponsetochemokinechemokine(C-X-Cmotif)ligand12signalingpathwaychemokine-mediatedsignalingpathwaychemotaxisdefenseresponsedetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainGprotein-coupledreceptorsignalingpathwayimmuneresponseinductionofpositivechemotaxisintegrinactivationkillingofcellsofanotherorganismnegativeregulationofdendriticcellapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofleukocytetetheringorrollingneuronmigrationpositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofcalciumionimportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofdopaminesecretionpositiveregulationofendothelialcellproliferationpositiveregulationofmonocytechemotaxispositiveregulationofneurondifferentiationpositiveregulationofTcellmigrationregulationofactinpolymerizationordepolymerizationresponsetoheatresponsetohypoxiaresponsetopeptidehormoneresponsetoradiationresponsetoultrasoundresponsetovirussignaltransductionTcellchemotaxistelencephaloncellmigration
Stromal cell-derived factor 1
71
Stromal cell-derived factor 1
265
9.7
76
0.14
SDF1SDF1P48061P48061adultlocomotorybehavioranimalorganregenerationantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideaxonguidancebloodcirculationcelladhesioncellchemotaxiscellularcalciumionhomeostasiscellularresponsetochemokinechemokine(C-X-Cmotif)ligand12signalingpathwaychemokine-mediatedsignalingpathwaychemotaxisdefenseresponsedetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainGprotein-coupledreceptorsignalingpathwayimmuneresponseinductionofpositivechemotaxisintegrinactivationkillingofcellsofanotherorganismnegativeregulationofdendriticcellapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofleukocytetetheringorrollingneuronmigrationpositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofcalciumionimportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofdopaminesecretionpositiveregulationofendothelialcellproliferationpositiveregulationofmonocytechemotaxispositiveregulationofneurondifferentiationpositiveregulationofTcellmigrationregulationofactinpolymerizationordepolymerizationresponsetoheatresponsetohypoxiaresponsetopeptidehormoneresponsetoradiationresponsetoultrasoundresponsetovirussignaltransductionTcellchemotaxistelencephaloncellmigration
Platelet factor 4
41
Platelet factor 4
43
9.9
61
0.17
PLF4PLF4P02776P02776adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaycytokine-mediatedsignalingpathwaydefenseresponsetoprotozoaninflammatoryresponsekillingbyhostofsymbiontcellskillingofcellsofanotherorganismleukocytechemotaxisnegativeregulationofangiogenesisnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofmegakaryocytedifferentiationnegativeregulationofMHCclassIIbiosyntheticprocessneutrophilchemotaxisplateletactivationpositiveregulationofgeneexpressionpositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofmacrophagedifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionregulationofcellpopulationproliferation
Beta-nerve growth factor
189
Beta-nerve growth factor
136
9.6
77
0.13
NGFNGFP01139P01139activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessadultlocomotorybehavioraxonextensioncircadianrhythmextrinsicapoptoticsignalingpathwayinabsenceofligandextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsmemorymodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnegativeregulationoftypeBpancreaticcellapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwayneuronapoptoticprocessneuronprojectiondevelopmentneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofaxonextensionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofcollateralsproutingpositiveregulationofDNAbindingpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofneurondifferentiationpositiveregulationofneuronmaturationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofneurotrophinTRKreceptorsignalingpathwaypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinautophosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinphosphorylationpositiveregulationofproteinubiquitinationpositiveregulationofRasproteinsignaltransductionpositiveregulationofstemcellproliferationproteinphosphorylationregulationofneurondifferentiationregulationofneurotransmittersecretionregulationofreleaseofsequesteredcalciumionintocytosolsensoryperceptionofpaintransmembranereceptorproteintyrosinekinasesignalingpathway
Hypoxia-inducible factor 1-alpha
800
Histone acetyltransferase p300
414
9.9
74
0.14
HIF1AEP300Q16665Q09472angiogenesisaxonaltransportofmitochondrionB-1Bcellhomeostasisbonemineralizationcardiacventriclemorphogenesiscellularglucosehomeostasiscellularironionhomeostasiscellularresponsetohypoxiacellularresponsetointerleukin-1cellularresponsetoviruscerebralcortexdevelopmentchondrocytedifferentiationcollagenmetabolicprocessconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingdigestivetractmorphogenesisdopaminergicneurondifferentiationelastinmetabolicprocessembryonichemopoiesisembryonicplacentadevelopmentepithelialcelldifferentiationinvolvedinmammaryglandalveolusdevelopmentepithelialtomesenchymaltransitionglandularepithelialcellmaturationheartloopinghemoglobinbiosyntheticprocesshypoxia-induciblefactor-1alphasignalingpathwayinsulinsecretioninvolvedincellularresponsetoglucosestimulusintestinalepithelialcellmaturationirismorphogenesislactatemetabolicprocesslactationmesenchymalcellapoptoticprocessmusclecellcellularhomeostasisnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofgrowthnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofthymocyteapoptoticprocessnegativeregulationofTORsignalingneuralcrestcellmigrationneuralfoldelevationformationneuroblastproliferationneuronapoptoticprocessoutflowtractmorphogenesisoxygenhomeostasispositiveregulationofangiogenesispositiveregulationofautophagyofmitochondrionpositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofchemokineproductionpositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellmigrationpositiveregulationoferythrocytedifferentiationpositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhormonebiosyntheticprocesspositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofmacroautophagypositiveregulationofmiRNAtranscriptionpositiveregulationofneuroblastproliferationpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofsignalingreceptoractivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofaerobicrespirationregulationofgeneexpressionregulationofglycolyticprocessregulationofproteinneddylationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetooxidativestressregulationoftranscriptionDNA-templatedregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetoironionresponsetomuscleactivityresponsetoreactiveoxygenspeciesretinavasculaturedevelopmentincamera-typeeyesignaltransductionTORsignalingvascularendothelialgrowthfactorproductionvisuallearninganimalorganmorphogenesisapoptoticprocessBcelldifferentiationbehavioraldefenseresponsecellcyclecellularresponsetoUVcircadianrhythmepigeneticmaintenanceofchromatinintranscription-competentconformationfacemorphogenesisfatcelldifferentiationheartdevelopmenthistoneacetylationhistoneH2BacetylationhistoneH3-K56acetylationhistoneH4acetylationinternalpeptidyl-lysineacetylationinternalproteinaminoacidacetylationintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorlearningormemorylungdevelopmentmacrophagederivedfoamcelldifferentiationmegakaryocytedevelopmentmulticellularorganismgrowthN-terminalpeptidyl-lysineacetylationnegativeregulationofgluconeogenesisnegativeregulationofprotein-containingcomplexassemblynegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentpeptidyl-lysineacetylationpeptidyl-lysinebutyrylationpeptidyl-lysinecrotonylationpeptidyl-lysinepropionylationplateletformationpositiveregulationbyhostofviraltranscriptionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofneuronprojectiondevelopmentpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofproteinbindingpositiveregulationofRNApolymeraseIIregulatoryregionsequence-specificDNAbindingpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedinunfoldedproteinresponsepositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayproteinacetylationproteindestabilizationproteinstabilizationregulationofandrogenreceptorsignalingpathwayregulationofautophagyregulationofcellularresponsetoheatregulationofmitochondrionorganizationregulationofsignaltransductionbyp53classmediatorregulationoftubulindeacetylationresponsetoestrogenskeletalmuscletissuedevelopmentsomitogenesisstimulatoryC-typelectinreceptorsignalingpathwayswimmingthigmotaxistranscriptionbyRNApolymeraseII
Stromal cell-derived factor 1
65
Stromal cell-derived factor 1
265
9.5
65
0.16
SDF1SDF1P48061P48061adultlocomotorybehavioranimalorganregenerationantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideaxonguidancebloodcirculationcelladhesioncellchemotaxiscellularcalciumionhomeostasiscellularresponsetochemokinechemokine(C-X-Cmotif)ligand12signalingpathwaychemokine-mediatedsignalingpathwaychemotaxisdefenseresponsedetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainGprotein-coupledreceptorsignalingpathwayimmuneresponseinductionofpositivechemotaxisintegrinactivationkillingofcellsofanotherorganismnegativeregulationofdendriticcellapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofleukocytetetheringorrollingneuronmigrationpositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofcalciumionimportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofdopaminesecretionpositiveregulationofendothelialcellproliferationpositiveregulationofmonocytechemotaxispositiveregulationofneurondifferentiationpositiveregulationofTcellmigrationregulationofactinpolymerizationordepolymerizationresponsetoheatresponsetohypoxiaresponsetopeptidehormoneresponsetoradiationresponsetoultrasoundresponsetovirussignaltransductionTcellchemotaxistelencephaloncellmigration
Tropomyosin alpha-1 chain
249
Tropomyosin alpha-1 chain
249
5.5
36
0.5
1
✔TPM1TPM1Q63609Q63609actinfilamentcappingactinfilamentorganizationcardiacmusclecontractioncellularresponsetoreactiveoxygenspeciesinuteroembryonicdevelopmentmusclecontractionmusclefilamentslidingnegativeregulationofcellmigrationnegativeregulationofvascularassociatedsmoothmusclecellmigrationnegativeregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofATP-dependentactivitypositiveregulationofcelladhesionpositiveregulationofheartratebyepinephrinepositiveregulationofstressfiberassemblyregulationofATP-dependentactivityregulationofcellshaperuffleorganizationsarcomereorganizationventricularcardiacmuscletissuemorphogenesiswoundhealing
C-C motif chemokine 2
75
C-C motif chemokine 2
34
10.0
80
0.13
CCL2CCL2P13500P13500angiogenesisanimalorganmorphogenesisastrocytecellmigrationcelladhesioncellsurfacereceptorsignalingpathwaycellularhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetolipopolysaccharidecellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytokine-mediatedsignalingpathwaycytoskeletonorganizationeosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerhelperTcellextravasationhumoralimmuneresponseinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofglialcellapoptoticprocessnegativeregulationofnaturalkillercellchemotaxisnegativeregulationofneuronapoptoticprocessnegativeregulationofvascularendothelialcellproliferationneutrophilchemotaxispositiveregulationofapoptoticcellclearancepositiveregulationofcalciumionimportpositiveregulationofendothelialcellapoptoticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofNMDAglutamatereceptoractivitypositiveregulationofsynaptictransmissionglutamatergicpositiveregulationofTcellactivationproteinkinaseBsignalingproteinphosphorylationreceptorsignalingpathwayviaJAK-STATregulationofcellshaperesponsetobacteriumsensoryperceptionofpainsignaltransductionviralgenomereplication
Protegrin-3
136
Protegrin-3
143
9.8
38
0.27
PG3PG3P32196P32196antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponse
Mitochondrial antiviral-signaling protein
33
Mitochondrial antiviral-signaling protein
13
9.8
63
0.16
MAVSMAVSQ7Z434Q7Z434activationofinnateimmuneresponsecellularresponsetoexogenousdsRNAdefenseresponsetobacteriumdefenseresponsetovirusinnateimmuneresponsenegativeregulationofviralgenomereplicationpositiveregulationofchemokine(C-Cmotif)ligand5productionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofIP-10productionpositiveregulationofmyeloiddendriticcellcytokineproductionpositiveregulationofproteinimportintonucleuspositiveregulationofproteinphosphorylationpositiveregulationofresponsetocytokinestimuluspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIinterferon-mediatedsignalingpathwayregulationofperoxisomeorganizationsignaltransductiontypeIinterferonsignalingpathway
Beta-2-microglobulin
45
Beta-2-microglobulin
45
9.9
50
0.2
B2MGB2MGP61769P61769amyloidfibrilformationantibacterialhumoralresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofexogenousproteinantigenviaMHCclassIbTAP-dependentantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetoironioncellularresponsetoiron(III)ioncellularresponsetolipopolysaccharidecellularresponsetonicotinedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseironionhomeostasisironiontransportlearningormemorynegativeregulationofepithelialcellproliferationnegativeregulationofforebrainneurondifferentiationnegativeregulationofneurogenesisnegativeregulationofneuronprojectiondevelopmentnegativeregulationofreceptorbindingpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofcellularsenescencepositiveregulationofferrousironbindingpositiveregulationofproteinbindingpositiveregulationofreceptorbindingpositiveregulationofreceptor-mediatedendocytosispositiveregulationofTcellactivationpositiveregulationofTcellcytokineproductionpositiveregulationofTcellmediatedcytotoxicitypositiveregulationoftransferrinreceptorbindingproteinhomotetramerizationproteinrefoldingregulationoferythrocytedifferentiationregulationofironiontransportregulationofmembranedepolarizationresponsetomoleculeofbacterialoriginretinahomeostasissensoryperceptionofsmellTcelldifferentiationinthymusTcellmediatedcytotoxicity
Receptor-interacting serine/threonine-protein kinase 3
445
Receptor-interacting serine/threonine-protein kinase 3
445
9.9
51
0.2
RIPK3RIPK3Q9QZL0Q9QZL0activationofproteinkinaseactivityamyloidfibrilformationapoptoticprocesscellularresponsetohydrogenperoxidedefenseresponsetovirusexecutionphaseofnecroptosisI-kappaBkinase/NF-kappaBsignalinglymphnodedevelopmentnecroptoticprocessnecroptoticsignalingpathwaypositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofligaseactivitypositiveregulationofnecroptoticprocesspositiveregulationofnecroticcelldeathpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofoxidoreductaseactivitypositiveregulationofphosphataseactivitypositiveregulationofreactiveoxygenspeciesmetabolicprocessprogrammednecroticcelldeathproteinautophosphorylationreactiveoxygenspeciesmetabolicprocessregulationofactivatedTcellproliferationregulationofactivation-inducedcelldeathofTcellsregulationofadaptiveimmuneresponseregulationofapoptoticprocessregulationofCD8-positivealpha-betacytotoxicTcellextravasationregulationofinterferon-gammaproductionregulationofreactiveoxygenspeciesmetabolicprocessregulationofTcellmediatedcytotoxicitysignaltransductionspleendevelopmentTcelldifferentiationinthymusTcellhomeostasisthymusdevelopment
Mitochondrial antiviral-signaling protein
46
Mitochondrial antiviral-signaling protein
46
9.8
74
0.14
MAVSMAVSQ7Z434Q7Z434activationofinnateimmuneresponsecellularresponsetoexogenousdsRNAdefenseresponsetobacteriumdefenseresponsetovirusinnateimmuneresponsenegativeregulationofviralgenomereplicationpositiveregulationofchemokine(C-Cmotif)ligand5productionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofIP-10productionpositiveregulationofmyeloiddendriticcellcytokineproductionpositiveregulationofproteinimportintonucleuspositiveregulationofproteinphosphorylationpositiveregulationofresponsetocytokinestimuluspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIinterferon-mediatedsignalingpathwayregulationofperoxisomeorganizationsignaltransductiontypeIinterferonsignalingpathway
Receptor-interacting serine/threonine-protein kinase 3
455
Receptor-interacting serine/threonine-protein kinase 3
455
8.5
70
0.17
RIPK3RIPK3Q9Y572Q9Y572activationofproteinkinaseactivityamyloidfibrilformationapoptoticsignalingpathwaycellularresponsetohydrogenperoxidedefenseresponsetovirusexecutionphaseofnecroptosisI-kappaBkinase/NF-kappaBsignalinglymphnodedevelopmentnecroptoticprocessnecroptoticsignalingpathwaypositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofligaseactivitypositiveregulationofnecroptoticprocesspositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofoxidoreductaseactivitypositiveregulationofphosphataseactivitypositiveregulationofreactiveoxygenspeciesmetabolicprocessprogrammednecroticcelldeathproteinautophosphorylationproteinmodificationprocessreactiveoxygenspeciesmetabolicprocessregulationofactivatedTcellproliferationregulationofactivation-inducedcelldeathofTcellsregulationofadaptiveimmuneresponseregulationofapoptoticprocessregulationofCD8-positivealpha-betacytotoxicTcellextravasationregulationofinterferon-gammaproductionregulationofTcellmediatedcytotoxicitysignaltransductionspleendevelopmentTcelldifferentiationinthymusTcellhomeostasisthymusdevelopment
Calcium homeostasis modulator protein 4
82
Calcium homeostasis modulator protein 4
205
5.3
39
0.48
CAHM4CAHM4Q5JW98Q5JW98
Calcium homeostasis modulator protein 2
204
Calcium homeostasis modulator protein 2
86
8.4
39
0.3
CAHM2CAHM2Q9HA72Q9HA72positiveregulationofapoptoticprocess
Transmembrane protein 106B
214
Transmembrane protein 106B
253
4.6
57
0.38
T106BT106BQ9NUM4Q9NUM4dendritemorphogenesislysosomallumenacidificationlysosomalproteincatabolicprocesslysosomaltransportlysosomelocalizationlysosomeorganizationneuroncellularhomeostasispositiveregulationofdendritedevelopmentpositiveregulationofhydrolaseactivityregulationoflysosomeorganization
Glycoprotein hormones alpha chain
55
Thyrotropin subunit beta
51
8.2
78
0.16
GLHATSHBP01215P01222follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationanatomicalstructuremorphogenesiscell-cellsignalingresponsetocalciumionresponsetoestrogenresponsetovitaminA
Potassium voltage-gated channel subfamily D member 2
406
Potassium voltage-gated channel subfamily D member 2
406
4.1
81
0.3
KCND2KCND2Q9NZV8Q9NZV8actionpotentialcellularresponsetohypoxiachemicalsynaptictransmissionlocomotorrhythmneuronalactionpotentialpotassiumiontransmembranetransportproteinhomooligomerizationregulationofiontransmembranetransportsensoryperceptionofpain
Calcium homeostasis modulator protein 4
209
Calcium homeostasis modulator protein 4
82
5.9
40
0.43
CAHM4CAHM4Q5JW98Q5JW98
Voltage-dependent calcium channel gamma-2 subunit
315
Voltage-dependent calcium channel gamma-2 subunit
63
7.2
69
0.2
CCG2CCG2Q9Y698Q9Y698eyeblinkreflexmembranedepolarizationmembranehyperpolarizationneuromuscularjunctiondevelopmentneurotransmitterreceptorinternalizationneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneneurotransmitterreceptortransportpostsynapticendosometolysosomepositiveregulationofAMPAreceptoractivitypositiveregulationofproteinlocalizationtobasolateralplasmamembranepositiveregulationofsynaptictransmissionglutamatergicpostsynapticneurotransmitterreceptordiffusiontrappingproteintargetingtomembraneregulationofAMPAreceptoractivityresponsetocalciumiontransmissionofnerveimpulse
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
186
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
155
8.2
88
0.14
NDUS7NDUS8P42026P42028aerobicrespirationelectrontransportcoupledprotontransportmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyresponsetooxidativestress
39S ribosomal protein L10, mitochondrial
64
39S ribosomal protein S18a, mitochondrial
108
3.5
53
0.53
RM10RT18AQ7Z7H8Q9NVS2mitochondrialtranslationtranslation
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
479
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
479
8.2
92
0.13
HCN4HCN4Q9TV66Q9TV66cellularresponsetocAMPpotassiumiontransmembranetransportregulationofheartrateregulationofiontransmembranetransport
Calcium homeostasis modulator protein 2
126
Calcium homeostasis modulator protein 2
180
8.0
81
0.15
CAHM2CAHM2Q9HA72Q9HA72positiveregulationofapoptoticprocess
Igh protein
249
Igh protein
306
6.8
nan
nan
Q99M22Q99M22Q99M22Q99M22
Germ cell-specific gene 1-like protein
315
Germ cell-specific gene 1-like protein
63
7.5
72
0.19
GSG1LGSG1LD3ZK93D3ZK93regulationofAMPAreceptoractivityregulationofpostsynapticneurotransmitterreceptoractivityregulationofpostsynapticneurotransmitterreceptorinternalization
Calcium homeostasis modulator protein 6
81
Calcium homeostasis modulator protein 6
198
6.1
41
0.4
CAHM6CAHM6Q5R3K3Q5R3K3
Germ cell-specific gene 1-like protein
315
Germ cell-specific gene 1-like protein
315
7.8
75
0.17
GSG1LGSG1LD3ZK93D3ZK93regulationofAMPAreceptoractivityregulationofpostsynapticneurotransmitterreceptoractivityregulationofpostsynapticneurotransmitterreceptorinternalization
Glycoprotein hormones alpha chain
31
Choriogonadotropin subunit beta 3
58
8.1
63
0.2
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
TMEM106B protein
293
TMEM106B protein
254
9.9
56
0.18
Q8N353Q8N353Q8N353Q8N353
Voltage-dependent calcium channel gamma-2 subunit
63
Voltage-dependent calcium channel gamma-2 subunit
315
8.4
75
0.16
CCG2CCG2O88602O88602eyeblinkreflexmembranedepolarizationmembranehyperpolarizationnervoussystemprocessneuromuscularjunctiondevelopmentneurotransmitterreceptorinternalizationneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneneurotransmitterreceptortransportpostsynapticendosometolysosomepositiveregulationofAMPAreceptoractivitypositiveregulationofproteinlocalizationtobasolateralplasmamembranepositiveregulationofsynaptictransmissionglutamatergicpostsynapticneurotransmitterreceptordiffusiontrappingproteintargetingtomembraneregulationofAMPAreceptoractivityregulationofmembranepotentialregulationofpostsynapticmembraneneurotransmitterreceptorlevelsregulationofpostsynapticneurotransmitterreceptoractivityresponsetocalciumiontransmissionofnerveimpulse
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
176
8.2
92
0.13
F1RVN1A0A287BG40F1RVN1A0A287BG40mitochondrialelectrontransportNADHtoubiquinonecardiacmuscletissuedevelopmentnervoussystemdevelopment
Glycoprotein hormones alpha chain
83
Thyrotropin subunit beta
51
8.8
81
0.14
GLHATSHBP01215P01222follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationanatomicalstructuremorphogenesiscell-cellsignalingresponsetocalciumionresponsetoestrogenresponsetovitaminA
39S ribosomal protein L10, mitochondrial
64
39S ribosomal protein S18a, mitochondrial
70
4.1
61
0.4
RM10RT18AQ7Z7H8Q9NVS2mitochondrialtranslationtranslation
DNA-directed RNA polymerase I subunit RPA2
535
DNA-directed RNA polymerase I subunit RPA49
81
8.2
74
0.16
RPA2RPA49Q9H9Y6Q9GZS1embryoimplantationneuralcrestformationnucleologenesisrRNAtranscriptionnucleolarlargerRNAtranscriptionbyRNApolymeraseIRNApolymeraseIpreinitiationcomplexassemblytranscriptionelongationfromRNApolymeraseIpromoter
Insulin receptor
712
Insulin receptor
714
6.7
28
0.54
INSRINSRP15208P15208activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearanceanimalorganmorphogenesiscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaymalegonaddevelopmentmalesexdeterminationnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofproteinphosphorylationnegativeregulationoftransporteractivityneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationofhydrogenperoxidemetabolicprocessregulationoftranscriptionDNA-templatedresponsetonutrientlevelsresponsetotumornecrosisfactortransmembranereceptorproteintyrosinekinasesignalingpathwayviralentryintohostcell
C-C motif chemokine 15
53
C-C chemokine receptor type 1
273
8.2
69
0.18
CCL15CCR1Q16663P32246cell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitysignaltransductioncalciumiontransportcalcium-mediatedsignalingcelladhesioncellchemotaxiscellsurfacereceptorsignalingpathwaycytokine-mediatedsignalingpathwaydendriticcellchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerimmuneresponsenegativeregulationofbonemineralizationnegativeregulationofgeneexpressionpositiveregulationofcalciumiontransportpositiveregulationofcellmigrationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofmonocytechemotaxispositiveregulationofosteoclastdifferentiationresponsetowounding
39S ribosomal protein L10, mitochondrial
64
39S ribosomal protein S18a, mitochondrial
73
3.5
61
0.48
RM10RT18AQ7Z7H8Q9NVS2mitochondrialtranslationtranslation
Neurturin
164
Neurturin
196
8.2
65
0.19
NRTNNRTNQ99748Q99748MAPKcascadenervedevelopmentnervoussystemdevelopmentneuralcrestcellmigrationneuronprojectiondevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathway
Glutamate receptor 2
610
Glutamate receptor 2
610
8.2
77
0.16
GRIA2GRIA2P19491P19491chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumion
von Willebrand factor
1091
von Willebrand factor
1097
8.5
78
0.15
VWFVWFP04275P04275bloodcoagulationcelladhesioncell-substrateadhesionhemostasisplateletactivationpositiveregulationofintracellularsignaltransductionresponsetowounding
Insulin
95
Insulin
31
8.8
67
0.17
INSINSP01308P01318activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealingcellularresponsetopalmitoleicacidresponsetoL-arginine
Extracellular calcium-sensing receptor
129
Extracellular calcium-sensing receptor
129
9.4
52
0.21
CASRCASRP41180P41180adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayanatomicalstructuremorphogenesisapoptoticprocessbileacidsecretionbranchingmorphogenesisofanepithelialtubecalciumionimportcellularcalciumionhomeostasiscellularresponsetoglucosestimuluscellularresponsetohepatocytegrowthfactorstimuluscellularresponsetohypoxiacellularresponsetolow-densitylipoproteinparticlestimuluscellularresponsetopeptidecellularresponsetovitaminDchemosensorybehaviorchloridetransmembranetransportdetectionofcalciumionfatpaddevelopmentGprotein-coupledreceptorsignalingpathwayJNKcascadeossificationphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofATP-dependentactivitypositiveregulationofcalciumionimportpositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofinsulinsecretionpositiveregulationofpositivechemotaxispositiveregulationofvasoconstrictionregulationofcalciumiontransportresponsetofibroblastgrowthfactorresponsetoischemiavasodilation
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
130
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
95
8.2
83
0.15
ISCUISCUQ9H1K1Q9H1K1cellularironionhomeostasisiron-sulfurclusterassemblynegativeregulationofironionimportacrossplasmamembranepositiveregulationofaconitatehydrataseactivitypositiveregulationofmitochondrialelectrontransportNADHtoubiquinone
General transcription factor IIH subunit 3
271
General transcription factor IIH subunit 2
247
8.5
78
0.15
TF2H3TF2H2Q13889Q13888DNArepairnucleotide-excisionrepairphosphorylationofRNApolymeraseIIC-terminaldomaintranscriptionbyRNApolymeraseIIGprotein-coupledreceptorinternalizationpositiveregulationofDNAhelicaseactivityregulationoftranscriptionbyRNApolymeraseIIresponsetoUVtranscriptioninitiationfromRNApolymeraseIIpromoter
Ion channel TACAN
68
Ion channel TACAN
12
7.0
41
0.35
TACANTACANQ8C1E7Q8C1E7detectionofmechanicalstimulusinvolvedinsensoryperceptionofpainfatcelldifferentiationiontransmembranetransportproteinheterooligomerizationproteinhomooligomerization
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
173
8.2
93
0.13
W5PUX0W5NRY1W5PUX0W5NRY1mitochondrialATPsynthesiscoupledelectrontransport
Calcium homeostasis modulator protein 4
210
Calcium homeostasis modulator protein 4
82
9.9
38
0.27
CAHM4CAHM4Q5JW98Q5JW98
Serine/threonine-protein kinase mTOR
1498
DEP domain-containing mTOR-interacting protein
304
7.2
nan
nan
MTORDPTORP42345Q8TB45"denovopyrimidinenucleobasebiosyntheticprocess"activationofproteinkinaseBactivityanoikisbehavioralresponsetopaincalcineurin-NFATsignalingcascadecardiacmusclecelldevelopmentcardiacmusclecontractioncellularresponsetoaminoacidstarvationcellularresponsetoaminoacidstimuluscellularresponsetoDNAdamagestimuluscellularresponsetohypoxiacellularresponsetoleucinecellularresponsetoleucinestarvationcellularresponsetonutrientlevelscellularresponsetoosmoticstresscellularresponsetostarvationcytoskeletonorganizationenergyreservemetabolicprocessgermcelldevelopmentheartmorphogenesisheartvalvemorphogenesisinflammatoryresponselysosomeorganizationmacroautophagymulticellularorganismgrowthnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofcalcineurin-NFATsignalingcascadenegativeregulationofcellsizenegativeregulationofmacroautophagyneuronalactionpotentialnucleuslocalizationoligodendrocytedifferentiationpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationphosphorylationpositiveregulationofactinfilamentpolymerizationpositiveregulationofcellgrowthpositiveregulationofcytoplasmictranslationalinitiationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofkeratinocytemigrationpositiveregulationoflamellipodiumassemblypositiveregulationoflipidbiosyntheticprocesspositiveregulationofmyotubedifferentiationpositiveregulationofoligodendrocytedifferentiationpositiveregulationofpentose-phosphateshuntpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphoproteinphosphataseactivitypositiveregulationofstressfiberassemblypositiveregulationoftranscriptionbyRNApolymeraseIIIpositiveregulationoftranscriptionofnucleolarlargerRNAbyRNApolymeraseIpositiveregulationoftranslationpositiveregulationofwoundhealingspreadingofepidermalcellspost-embryonicdevelopmentproteinautophosphorylationproteincatabolicprocessproteinphosphorylationregulationofactincytoskeletonorganizationregulationofcellgrowthregulationofcellsizeregulationofcellularresponsetoheatregulationofcircadianrhythmregulationofGTPaseactivityregulationoflocomotorrhythmregulationofmacroautophagyregulationofmembranepermeabilityregulationofmyelinationregulationofosteoclastdifferentiationregulationofproteinkinaseBsignalingregulationofsignaltransductionbyp53classmediatorresponsetoaminoacidresponsetoheatresponsetoinsulinresponsetonutrientresponsetonutrientlevelsrhythmicprocessruffleorganizationT-helper1celllineagecommitmentTORsignalingTORC1signalingvoluntarymusculoskeletalmovementintracellularsignaltransductionnegativeregulationofproteinkinaseactivitynegativeregulationofTORsignalingnegativeregulationofTORC1signalingnegativeregulationofTORC2signalingregulationofextrinsicapoptoticsignalingpathway
Transmembrane protein 120B
64
Transmembrane protein 120B
8
6.5
48
0.32
T120BT120BA0PK00A0PK00fatcelldifferentiationproteinheterooligomerization
F-box/LRR-repeat protein 5
226
S-phase kinase-associated protein 1
160
4.8
nan
nan
FBXL5SKP1Q9UKA1P63208ironionhomeostasispositiveregulationofproteincatabolicprocessproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocesshistoneH2AmonoubiquitinationmaintenanceofproteinlocationinnucleuspositiveregulationofubiquitinproteinligaseactivityproteinK48-linkedubiquitinationproteinpolyubiquitination
Transient receptor potential cation channel subfamily V member 3
75
Transient receptor potential cation channel subfamily V member 3
731
9.1
45
0.24
TRPV3TRPV3Q8K424Q8K424calciumionimportacrossplasmamembranenegativeregulationofhaircyclepositiveregulationofcalciumionimportresponsetoheatresponsetotemperaturestimulus
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
286
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
225
8.2
97
0.12
F1RVN1A0A287BG40F1RVN1A0A287BG40mitochondrialelectrontransportNADHtoubiquinonecardiacmuscletissuedevelopmentnervoussystemdevelopment
Phosphatidylinositol 4-kinase alpha
1611
Tetratricopeptide repeat protein 7B
423
8.2
74
0.16
PI4KATTC7BP42356Q86TV6modulationbyhostofviralprocessphosphatidylinositolbiosyntheticprocessphosphatidylinositolphosphatebiosyntheticprocessphosphatidylinositol-mediatedsignalingphosphorylationreorganizationofcellularmembranestoestablishviralsitesofreplicationsignaltransductionproteinlocalizationtoplasmamembrane
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
137
8.4
93
0.13
W5PUX0W5NRY1W5PUX0W5NRY1mitochondrialATPsynthesiscoupledelectrontransport
Germ cell-specific gene 1-like protein
315
Germ cell-specific gene 1-like protein
315
6.7
76
0.2
GSG1LGSG1LD3Z7H4D3Z7H4regulationofAMPAreceptoractivityregulationofpostsynapticneurotransmitterreceptorinternalization
Germ cell-specific gene 1-like protein
315
Germ cell-specific gene 1-like protein
63
7.7
75
0.17
GSG1LGSG1LD3Z7H4D3Z7H4regulationofAMPAreceptoractivityregulationofpostsynapticneurotransmitterreceptorinternalization
DNA-directed RNA polymerase III subunit RPC2
527
DNA-directed RNA polymerase III subunit RPC4
354
8.4
78
0.15
RPC2RPC4Q9NW08P05423defenseresponsetovirusinnateimmuneresponsepositiveregulationofinnateimmuneresponsepositiveregulationofinterferon-betaproductiontranscriptionDNA-templatedtranscriptionbyRNApolymeraseIII
Zinc transporter 8
53
Zinc transporter 8
364
6.3
67
0.24
ZNT8ZNT8Q8IWU4Q8IWU4cellularzincionhomeostasisinsulinprocessinginsulinsecretionpositiveregulationofinsulinsecretionregulationofsequesteringofzincionregulationofvesicle-mediatedtransportresponsetoglucoseresponsetointerferon-gammaresponsetointerleukin-1responsetozincionsequesteringofzincionzinciontransmembranetransportzinciontransport
Ribonuclease P/MRP protein subunit POP5
146
Ribonuclease P protein subunit p20
66
7.2
52
0.27
POP5POP7Q969H6O75817rRNAprocessing"tRNA5-leaderremoval"tRNAprocessingRNAphosphodiesterbondhydrolysisendonucleolytic
Calcium homeostasis modulator protein 4
83
Calcium homeostasis modulator protein 4
205
9.8
nan
nan
CAHM4CAHM4Q5JW98Q5JW98
Voltage-dependent calcium channel gamma-2 subunit
589
Voltage-dependent calcium channel gamma-2 subunit
589
6.8
69
0.21
CCG2CCG2Q9Y698Q9Y698eyeblinkreflexmembranedepolarizationmembranehyperpolarizationneuromuscularjunctiondevelopmentneurotransmitterreceptorinternalizationneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneneurotransmitterreceptortransportpostsynapticendosometolysosomepositiveregulationofAMPAreceptoractivitypositiveregulationofproteinlocalizationtobasolateralplasmamembranepositiveregulationofsynaptictransmissionglutamatergicpostsynapticneurotransmitterreceptordiffusiontrappingproteintargetingtomembraneregulationofAMPAreceptoractivityresponsetocalciumiontransmissionofnerveimpulse
T-cell surface glycoprotein CD3 delta chain
96
T-cell surface glycoprotein CD3 epsilon chain
119
8.4
63
0.19
CD3DCD3EP04234P07766adaptiveimmuneresponsealpha-betaTcellactivationcellsurfacereceptorsignalingpathwaypositivethymicTcellselectionTcellreceptorsignalingpathwayapoptoticsignalingpathwaycalcium-mediatedsignalingCD4-positivealpha-betaTcellproliferationcerebellumdevelopmentdendritedevelopmentGprotein-coupledreceptorsignalingpathwaygamma-deltaTcellactivationnegativeregulationofgeneexpressionnegativeregulationofsmoothenedsignalingpathwaynegativethymicTcellselectionpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofgeneexpressionpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofTcellanergypositiveregulationofTcellproliferationprotein-containingcomplexassemblyregulationofapoptoticprocesssignalcomplexassemblysmoothenedsignalingpathwayTcellactivationTcellanergyTcellcostimulationtransmembranereceptorproteintyrosinekinasesignalingpathway
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
139
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
8.4
94
0.13
NDUV2NDUV1Q9D6J6Q91YT0aerobicrespirationcardiacmuscletissuedevelopmentmitochondrialelectrontransportNADHtoubiquinonenervoussystemdevelopmentprotonmotiveforce-drivenmitochondrialATPsynthesismitochondrialATPsynthesiscoupledelectrontransport
Inosine-5'-monophosphate dehydrogenase 1
468
Inosine-5'-monophosphate dehydrogenase 1
339
8.8
91
0.12
IMDH1IMDH1P20839P20839GMPbiosyntheticprocessGTPbiosyntheticprocess
Calcium homeostasis modulator protein 4
209
Calcium homeostasis modulator protein 4
83
6.6
nan
nan
CAHM4CAHM4Q5JW98Q5JW98
39S ribosomal protein L37, mitochondrial
153
39S ribosomal protein S30, mitochondrial
292
8.3
61
0.2
RM37RT30Q9BZE1Q9NP92mitochondrialtranslationtranslationapoptoticprocess
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
186
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
152
8.3
95
0.13
NDUS7NDUS8P42026P42028aerobicrespirationelectrontransportcoupledprotontransportmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyresponsetooxidativestress
Germ cell-specific gene 1-like protein
63
Germ cell-specific gene 1-like protein
63
8.0
68
0.18
GSG1LGSG1LD3ZK93D3ZK93regulationofAMPAreceptoractivityregulationofpostsynapticneurotransmitterreceptoractivityregulationofpostsynapticneurotransmitterreceptorinternalization
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
154
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
166
8.4
95
0.13
A0A287BDC0I3LK43A0A287BDC0I3LK43
ATP synthase F(0) complex subunit C2, mitochondrial
132
ATP synthase F(0) complex subunit C2, mitochondrial
132
8.3
98
0.12
AT5G2AT5G2P07926P07926protonmotiveforce-drivenATPsynthesis
Voltage-dependent calcium channel gamma-2 subunit
315
Voltage-dependent calcium channel gamma-2 subunit
315
7.0
68
0.21
CCG2CCG2Q9Y698Q9Y698eyeblinkreflexmembranedepolarizationmembranehyperpolarizationneuromuscularjunctiondevelopmentneurotransmitterreceptorinternalizationneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneneurotransmitterreceptortransportpostsynapticendosometolysosomepositiveregulationofAMPAreceptoractivitypositiveregulationofproteinlocalizationtobasolateralplasmamembranepositiveregulationofsynaptictransmissionglutamatergicpostsynapticneurotransmitterreceptordiffusiontrappingproteintargetingtomembraneregulationofAMPAreceptoractivityresponsetocalciumiontransmissionofnerveimpulse
Translation initiation factor eIF-2B subunit beta
194
Translation initiation factor eIF-2B subunit delta
465
9.7
77
0.13
EI2BBEI2BDP49770Q9UI10centralnervoussystemdevelopmentmyelinationoligodendrocytedevelopmentovarianfollicledevelopmentregulationofcatalyticactivityregulationoftranslationalinitiationresponsetoglucoseresponsetoheatresponsetopeptidehormoneTcellreceptorsignalingpathwaytranslationalinitiationregulationoftranslation
von Willebrand factor
1097
von Willebrand factor
1126
8.4
69
0.17
VWFVWFP04275P04275bloodcoagulationcelladhesioncell-substrateadhesionhemostasisplateletactivationpositiveregulationofintracellularsignaltransductionresponsetowounding
Voltage-dependent calcium channel gamma-2 subunit
589
Voltage-dependent calcium channel gamma-2 subunit
589
7.6
70
0.19
CCG2CCG2O88602O88602eyeblinkreflexmembranedepolarizationmembranehyperpolarizationnervoussystemprocessneuromuscularjunctiondevelopmentneurotransmitterreceptorinternalizationneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneneurotransmitterreceptortransportpostsynapticendosometolysosomepositiveregulationofAMPAreceptoractivitypositiveregulationofproteinlocalizationtobasolateralplasmamembranepositiveregulationofsynaptictransmissionglutamatergicpostsynapticneurotransmitterreceptordiffusiontrappingproteintargetingtomembraneregulationofAMPAreceptoractivityregulationofmembranepotentialregulationofpostsynapticmembraneneurotransmitterreceptorlevelsregulationofpostsynapticneurotransmitterreceptoractivityresponsetocalciumiontransmissionofnerveimpulse
Germ cell-specific gene 1-like protein
63
Germ cell-specific gene 1-like protein
63
8.5
80
0.15
GSG1LGSG1LD3Z7H4D3Z7H4regulationofAMPAreceptoractivityregulationofpostsynapticneurotransmitterreceptorinternalization
Clathrin heavy chain 1
1569
Clathrin light chain B
198
8.4
70
0.17
CLH1CLCBP49951P04975amyloid-betaclearancebytranscytosisautophagycelldivisionclathrincoatassemblyclathrin-dependentendocytosisintracellularproteintransportmitoticcellcyclenegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofproteinlocalizationtoplasmamembranereceptorinternalizationreceptor-mediatedendocytosisregulationofmitoticspindleorganizationretrogradetransportendosometoGolgitransferrintransport
P2X purinoceptor 7
4
P2X purinoceptor 7
362
5.8
nan
nan
P2RX7P2RX7Q64663Q64663apoptoticsignalingpathwayATPexportblebassemblycalciumiontransportcationtransportcelldeathcellmorphogenesiscellsurfacereceptorsignalingpathwaycellvolumehomeostasiscellularresponsetodsRNAcellularresponsetoextracellularstimuluscellularresponsetoorganiccycliccompoundceramidebiosyntheticprocesscollagenmetabolicprocessdefenseresponsetoGram-positivebacteriumextrinsicapoptoticsignalingpathwaygeneexpressionhomeostasisofnumberofcellswithinatissueinflammatoryresponsemembranedepolarizationmembraneproteinectodomainproteolysismitochondrionorganizationNADtransportnegativeregulationofboneresorptionnegativeregulationofcellvolumenegativeregulationofMAPKcascadeneuronalactionpotentialorganiccationtransportphagolysosomeassemblyphospholipidtransfertomembranephospholipidtranslocationplasmamembraneorganizationplasmamembranephospholipidscramblingporecomplexassemblypositiveregulationofapoptoticprocesspositiveregulationofblebassemblypositiveregulationofbonemineralizationpositiveregulationofcalciumiontransportintocytosolpositiveregulationofcatalyticactivitypositiveregulationofcytokineproductionpositiveregulationofcytoskeletonorganizationpositiveregulationofgamma-aminobutyricacidsecretionpositiveregulationofgeneexpressionpositiveregulationofglutamatesecretionpositiveregulationofglycolyticprocesspositiveregulationofinterleukin-1alphaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofiontransmembranetransportpositiveregulationoflymphocyteapoptoticprocesspositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmitochondrialdepolarizationpositiveregulationofossificationpositiveregulationofprostaglandinsecretionpositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofTcellmediatedcytotoxicityprogrammedcelldeathproteincatabolicprocessproteinphosphorylationproteinprocessingpurinergicnucleotidereceptorsignalingpathwayreactiveoxygenspeciesmetabolicprocessregulationofpresynapticdensecoregranuleexocytosisregulationofsodiumiontransportreleaseofsequesteredcalciumionintocytosolresponsetoATPresponsetobacteriumresponsetocalciumionresponsetoelectricalstimulusresponsetofluidshearstressresponsetolipopolysaccharideresponsetomechanicalstimulusresponsetoorganiccycliccompoundresponsetoorganicsubstanceresponsetoxenobioticstimulusresponsetozincionsensoryperceptionofpainskeletalsystemmorphogenesissynapticvesicleexocytosisTcellhomeostasisTcellproliferationvesiclebuddingfrommembrane
Translation initiation factor eIF-2B subunit beta
198
Translation initiation factor eIF-2B subunit delta
465
3.6
69
0.4
EI2BBEI2BDP49770Q9UI10centralnervoussystemdevelopmentmyelinationoligodendrocytedevelopmentovarianfollicledevelopmentregulationofcatalyticactivityregulationoftranslationalinitiationresponsetoglucoseresponsetoheatresponsetopeptidehormoneTcellreceptorsignalingpathwaytranslationalinitiationregulationoftranslation
Neuronal acetylcholine receptor subunit alpha-4
271
Neuronal acetylcholine receptor subunit beta-2
262
8.5
63
0.19
ACHA4ACHB2P43681P17787actionpotentialBcellactivationbehavioralresponsetonicotinecalciumiontransportchemicalsynaptictransmissioncognitionDNArepairinhibitorypostsynapticpotentialiontransmembranetransportiontransportmembranedepolarizationnervoussystemprocessregulationofdopaminesecretionregulationofmembranepotentialresponsetohypoxiaresponsetonicotineresponsetooxidativestresssensoryperceptionofpainsignaltransductionsynaptictransmissioncholinergicacetylcholinereceptorsignalingpathwayassociativelearningcentralnervoussystemprojectionneuronaxonogenesislateralgeniculatenucleusdevelopmentlearninglocomotorybehaviormemorynegativeregulationofactionpotentialopticnervemorphogenesispositiveregulationofBcellproliferationpositiveregulationofdopaminesecretionregulationofcircadiansleep/wakecycleREMsleepregulationofdendritemorphogenesisregulationofdopaminemetabolicprocessregulationofsynapseassemblyregulationofsynaptictransmissiondopaminergicresponsetoacetylcholineresponsetococaineresponsetoethanolsensoryperceptionofsoundsmoothmusclecontractionsocialbehaviorsynaptictransmissioninvolvedinmicturitionvestibulocochlearnervedevelopmentvisuallearningvisualperception
Microtubule-associated protein tau
639
Microtubule-associated protein tau
608
5.3
58
0.33
TAUTAUP10636P10636activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessamyloidfibrilformationastrocyteactivationaxondevelopmentaxonaltransportaxonaltransportofmitochondrioncell-cellsignalingcellularresponsetobrain-derivedneurotrophicfactorstimuluscellularresponsetoheatcellularresponsetonervegrowthfactorstimuluscellularresponsetoreactiveoxygenspeciescentralnervoussystemneurondevelopmentcytoplasmicmicrotubuleorganizationgenerationofneuronsinternalproteinaminoacidacetylationintracellulardistributionofmitochondrialearningormemorymemorymicroglialcellactivationmicrotubulecytoskeletonorganizationmicrotubulepolymerizationnegativeregulationofestablishmentofproteinlocalizationtomitochondrionnegativeregulationofgeneexpressionnegativeregulationofkinaseactivitynegativeregulationofmitochondrialfissionnegativeregulationofmitochondrialmembranepotentialnegativeregulationoftubulindeacetylationneurofibrillarytangleassemblyneuronprojectiondevelopmentplus-end-directedorganelletransportalongmicrotubulepositiveregulationofaxonextensionpositiveregulationofdiacylglycerolkinaseactivitypositiveregulationofmicrotubulepolymerizationpositiveregulationofneurondeathpositiveregulationofproteinlocalizationpositiveregulationofproteinlocalizationtosynapsepositiveregulationofsuperoxideaniongenerationproteinhomooligomerizationproteinpolymerizationregulationofautophagyregulationofcalcium-mediatedsignalingregulationofcellularresponsetoheatregulationofchromosomeorganizationregulationoflong-termsynapticdepressionregulationofmicrotubulecytoskeletonorganizationregulationofmicrotubulepolymerizationregulationofmicrotubulepolymerizationordepolymerizationregulationofmitochondrialfissionregulationofresponsetoDNAdamagestimulusregulationofsynapticplasticityresponsetoleadionrRNAmetabolicprocessstressgranuleassemblysupramolecularfiberorganizationsynapseassemblysynapseorganization
Voltage-dependent calcium channel gamma-2 subunit
315
Voltage-dependent calcium channel gamma-2 subunit
315
8.6
75
0.16
CCG2CCG2O88602O88602eyeblinkreflexmembranedepolarizationmembranehyperpolarizationnervoussystemprocessneuromuscularjunctiondevelopmentneurotransmitterreceptorinternalizationneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneneurotransmitterreceptortransportpostsynapticendosometolysosomepositiveregulationofAMPAreceptoractivitypositiveregulationofproteinlocalizationtobasolateralplasmamembranepositiveregulationofsynaptictransmissionglutamatergicpostsynapticneurotransmitterreceptordiffusiontrappingproteintargetingtomembraneregulationofAMPAreceptoractivityregulationofmembranepotentialregulationofpostsynapticmembraneneurotransmitterreceptorlevelsregulationofpostsynapticneurotransmitterreceptoractivityresponsetocalciumiontransmissionofnerveimpulse
F-box/WD repeat-containing protein 8
139
S-phase kinase-associated protein 1
160
9.4
nan
nan
FBXW8SKP1Q8N3Y1P63208cellpopulationproliferationGolgiorganizationlabyrinthinelayerbloodvesseldevelopmentpositiveregulationofdendritemorphogenesispositiveregulationoftranscriptionfactorcatabolicprocessproteinubiquitinationspongiotrophoblastlayerdevelopmenthistoneH2AmonoubiquitinationmaintenanceofproteinlocationinnucleuspositiveregulationofubiquitinproteinligaseactivityproteinK48-linkedubiquitinationproteinpolyubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocess
Integrator complex subunit 2
722
Integrator complex subunit 7
82
8.3
77
0.16
INT2INT7Q9H0H0Q9NVH2regulationoftranscriptionelongationfromRNApolymeraseIIpromoter"snRNA3-endprocessing"snRNAprocessingcellularresponsetoionizingradiationDNAdamagecheckpointsignaling
Transient receptor potential cation channel subfamily V member 3
721
Transient receptor potential cation channel subfamily V member 3
75
6.1
41
0.4
TRPV3TRPV3Q8K424Q8K424calciumionimportacrossplasmamembranenegativeregulationofhaircyclepositiveregulationofcalciumionimportresponsetoheatresponsetotemperaturestimulus
26S proteasome non-ATPase regulatory subunit 2
236
26S proteasome regulatory subunit 4
58
6.6
62
0.25
PSMD2PRS4Q4FZT9P62193proteasome-mediatedubiquitin-dependentproteincatabolicprocessregulationofproteincatabolicprocessnegativeregulationofneurondeath
COP9 signalosome complex subunit 6
264
COP9 signalosome complex subunit 7b
181
9.5
55
0.19
CSN6CSN7BQ7L5N1Q9H9Q2proteindeneddylationproteinneddylationregulationofproteinneddylationCOP9signalosomeassembly
Pre-mRNA-processing-splicing factor 8
719
SNW domain-containing protein 1
250
8.8
67
0.17
PRP8SNW1Q6P2Q9Q13573cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactormRNAprocessingmRNAsplicingviaspliceosomeRNAsplicingRNAsplicingviatransesterificationreactionsspliceosomaltri-snRNPcomplexassemblycellularresponsetoretinoicacidintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatornegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationbyhostofviraltranscriptionpositiveregulationofhistoneH3-K4methylationpositiveregulationofmRNAsplicingviaspliceosomepositiveregulationofneurogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofvitaminDreceptorsignalingpathwayregulationofretinoicacidreceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationofvitaminDreceptorsignalingpathwayretinoicacidreceptorsignalingpathway
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
224
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
286
8.2
98
0.12
NDUV2NDUV1Q9D6J6Q91YT0aerobicrespirationcardiacmuscletissuedevelopmentmitochondrialelectrontransportNADHtoubiquinonenervoussystemdevelopmentprotonmotiveforce-drivenmitochondrialATPsynthesismitochondrialATPsynthesiscoupledelectrontransport
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
140
8.3
93
0.13
F1RVN1A0A287BG40F1RVN1A0A287BG40mitochondrialelectrontransportNADHtoubiquinonecardiacmuscletissuedevelopmentnervoussystemdevelopment
Diacylglycerol O-acyltransferase 1
68
Diacylglycerol O-acyltransferase 1
262
3.9
64
0.4
DGAT1DGAT1O75907O75907diacylglycerolmetabolicprocessfattyacidhomeostasislipidstoragelong-chainfatty-acyl-CoAmetabolicprocessmonoacylglycerolbiosyntheticprocesstriglyceridebiosyntheticprocesstriglyceridemetabolicprocessvery-low-densitylipoproteinparticleassembly
Glycoprotein hormones alpha chain
31
Choriogonadotropin subunit beta 3
110
8.9
60
0.19
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
Insulin receptor
710
Insulin receptor
709
8.2
46
0.26
INSRINSRP06213P06213activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearancecarbohydratemetabolicprocesscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaylearningmalegonaddevelopmentmalesexdeterminationmemoryneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationoftranscriptionDNA-templatedtransmembranereceptorproteintyrosinekinasesignalingpathwaytransportacrossblood-brainbarrierviralentryintohostcell
DNA-directed RNA polymerase III subunit RPC2
919
DNA-directed RNA polymerases I, II, and III subunit RPABC5
44
8.4
80
0.15
RPC2RPAB5Q9NW08P62875defenseresponsetovirusinnateimmuneresponsepositiveregulationofinnateimmuneresponsepositiveregulationofinterferon-betaproductiontranscriptionDNA-templatedregulationoftranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseIItRNAtranscriptionbyRNApolymeraseIII
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
358
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
358
8.2
90
0.14
HCN1HCN1O60741O60741apicalproteinlocalizationcellularresponsetocAMPnegativeregulationofsynaptictransmissionglutamatergicpotassiumiontransmembranetransportproteinhomotetramerizationregulationofcationchannelactivityregulationofheartratebycardiacconductionregulationofmembranedepolarizationregulationofmembranepotentialregulationofSAnodecellactionpotentialretinalconecelldevelopmentsodiumiontransmembranetransport
NADH-ubiquinone oxidoreductase chain 6
16
NADH-ubiquinone oxidoreductase chain 4L
32
8.2
100
0.12
NU6MNU4LMP03925P03903aerobicrespirationmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyprotonmotiveforce-drivenmitochondrialATPsynthesisresponsetococaineresponsetohydrogenperoxideresponsetonicotineATPsynthesiscoupledelectrontransport
Insulin receptor
674
Insulin receptor
911
8.3
57
0.21
INSRINSRP06213P06213activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearancecarbohydratemetabolicprocesscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaylearningmalegonaddevelopmentmalesexdeterminationmemoryneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationoftranscriptionDNA-templatedtransmembranereceptorproteintyrosinekinasesignalingpathwaytransportacrossblood-brainbarrierviralentryintohostcell
Clathrin heavy chain
1569
Clathrin light chain
178
8.5
75
0.16
C0MHR2F1S398C0MHR2F1S398clathrincoatassemblyintracellularproteintransportmitoticcellcyclereceptor-mediatedendocytosisclathrin-dependentendocytosis
Lutropin-choriogonadotropic hormone receptor
156
Choriogonadotropin subunit beta 3
120
8.2
83
0.15
LSHRCGB3P22888P0DN86activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayarachidonicacidsecretioncellularresponsetogonadotropinstimuluscellularresponsetoluteinizinghormonestimuluscentralnervoussystemdevelopmentcognitiondevelopmentofsecondarymalesexualcharacteristicsGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerhormone-mediatedsignalingpathwayluteinizinghormonesignalingpathwaymalegenitaliadevelopmentmalegonaddevelopmentovarianfollicledevelopmentovulationcycleprocessphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcalciumiontransportintocytosolpositiveregulationofcalcium-mediatedsignalingpositiveregulationofhormonebiosyntheticprocesspositiveregulationofinositoltrisphosphatebiosyntheticprocesspositiveregulationofreleaseofsequesteredcalciumionintocytosolproteintargetingtolysosomeregulationofsteroidhormonebiosyntheticprocessresponsetoxenobioticstimulusseminiferoustubuledevelopmentspermatogenesisuterusdevelopmentapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
151
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
166
8.3
96
0.13
A0A287BDC0I3LK43A0A287BDC0I3LK43
Glycoprotein hormones alpha chain
31
Thyrotropin subunit beta
51
7.3
53
0.26
GLHATSHBP01215P01222follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationanatomicalstructuremorphogenesiscell-cellsignalingresponsetocalciumionresponsetoestrogenresponsetovitaminA
Dynactin subunit 6
18
Dynactin subunit 5
29
8.2
68
0.18
D0G6S1A0A286ZK88D0G6S1A0A286ZK88mitoticspindleorganizationaortadevelopmentcoronaryvasculaturedevelopmentventricularseptumdevelopment
Voltage-dependent calcium channel gamma-2 subunit
63
Voltage-dependent calcium channel gamma-2 subunit
63
7.8
67
0.19
CCG2CCG2Q9Y698Q9Y698eyeblinkreflexmembranedepolarizationmembranehyperpolarizationneuromuscularjunctiondevelopmentneurotransmitterreceptorinternalizationneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneneurotransmitterreceptortransportpostsynapticendosometolysosomepositiveregulationofAMPAreceptoractivitypositiveregulationofproteinlocalizationtobasolateralplasmamembranepositiveregulationofsynaptictransmissionglutamatergicpostsynapticneurotransmitterreceptordiffusiontrappingproteintargetingtomembraneregulationofAMPAreceptoractivityresponsetocalciumiontransmissionofnerveimpulse
Broad substrate specificity ATP-binding cassette transporter ABCG2
603
Broad substrate specificity ATP-binding cassette transporter ABCG2
592
8.5
53
0.22
ABCG2ABCG2Q9UNQ0Q9UNQ0biotintransportcellulardetoxificationexportacrossplasmamembranelipidtransportorganicaniontransportrenaluratesaltexcretionriboflavintransporttransepithelialtransporttransmembranetransporttransportacrossblood-brainbarrieruratemetabolicprocessxenobiotictransportacrossblood-brainbarrier
Igh protein
249
Igh protein
308
8.3
nan
nan
Q99M22Q99M22Q99M22Q99M22
GATOR complex protein NPRL2
286
GATOR complex protein NPRL3
343
9.3
48
0.22
NPRL2NPRL3Q8WTW4Q12980cellularresponsetoaminoacidstarvationnegativeregulationofkinaseactivitynegativeregulationofTORsignalingnegativeregulationofTORC1signalingpositiveregulationofautophagyaortamorphogenesiscardiacmuscletissuedevelopmentroofofmouthdevelopmentTORC1signalingventricularseptumdevelopment
Voltage-dependent calcium channel gamma-2 subunit
63
Voltage-dependent calcium channel gamma-2 subunit
63
8.4
72
0.17
CCG2CCG2O88602O88602eyeblinkreflexmembranedepolarizationmembranehyperpolarizationnervoussystemprocessneuromuscularjunctiondevelopmentneurotransmitterreceptorinternalizationneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneneurotransmitterreceptortransportpostsynapticendosometolysosomepositiveregulationofAMPAreceptoractivitypositiveregulationofproteinlocalizationtobasolateralplasmamembranepositiveregulationofsynaptictransmissionglutamatergicpostsynapticneurotransmitterreceptordiffusiontrappingproteintargetingtomembraneregulationofAMPAreceptoractivityregulationofmembranepotentialregulationofpostsynapticmembraneneurotransmitterreceptorlevelsregulationofpostsynapticneurotransmitterreceptoractivityresponsetocalciumiontransmissionofnerveimpulse
Kinetochore protein Spc25
232
Kinetochore protein Spc24
134
4.4
67
0.34
SPC25SPC24Q9HBM1C9JGC4attachmentofspindlemicrotubulestokinetochorecelldivisionchromosomesegregationmitoticspindleassemblycheckpointsignalingmitoticspindleorganization
Glutamate receptor ionotropic, kainate 2
595
Glutamate receptor ionotropic, kainate 2
595
8.5
37
0.32
GRIK2GRIK2P42260P42260behavioralfearresponsecellularcalciumionhomeostasischemicalsynaptictransmissiondetectionofcoldstimulusinvolvedinthermoceptionexcitatorypostsynapticpotentialinhibitorypostsynapticpotentialmodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnegativeregulationofsynaptictransmissionglutamatergicneuronapoptoticprocessneuronalactionpotentialpositiveregulationofneuronapoptoticprocesspositiveregulationofsynaptictransmissionpresynapticmodulationofchemicalsynaptictransmissionreceptorclusteringregulationofJNKcascaderegulationoflong-termneuronalsynapticplasticityregulationofmembranepotentialregulationofshort-termneuronalsynapticplasticitysynaptictransmissionglutamatergic
Glutamate receptor 1
75
Glutamate receptor 2
78
8.2
70
0.17
GRIA1GRIA2P19490P19491cellularresponsetoaminestimuluscellularresponsetoaminoacidstimuluscellularresponsetoammoniumioncellularresponsetodsRNAcellularresponsetogrowthfactorstimuluscellularresponsetoorganiccycliccompoundcellularresponsetopeptidehormonestimuluschemicalsynaptictransmissionlong-termmemorylong-termsynapticdepressionmodulationofchemicalsynaptictransmissionneuronalactionpotentialpositiveregulationofmembranepotentialpositiveregulationofsynaptictransmissionreceptorinternalizationregulationofpostsynapticmembranepotentialregulationofreceptorrecyclingregulationofsynapticplasticityresponsetoarsenic-containingsubstanceresponsetococaineresponsetoelectricalstimulusresponsetoestradiolresponsetofungicideresponsetolithiumionresponsetoorganiccycliccompoundresponsetopeptidehormoneresponsetotoxicsubstanceresponsetoxenobioticstimulusspinalcorddevelopmentsynaptictransmissionglutamatergicestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwayproteintetramerizationregulationofsynaptictransmissionglutamatergic
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
225
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
286
8.2
100
0.12
NDUV2NDUV1P04394P25708cardiacmuscletissuedevelopmentmitochondrialelectrontransportNADHtoubiquinonenervoussystemdevelopment
Neuronal acetylcholine receptor subunit alpha-3
269
Neuronal acetylcholine receptor subunit beta-4
260
8.2
66
0.19
ACHA3ACHB4P32297P30926acetylcholinereceptorsignalingpathwayactivationoftransmembranereceptorproteintyrosinekinaseactivitybehavioralresponsetonicotinechemicalsynaptictransmissionexcitatorypostsynapticpotentialiontransmembranetransportiontransportlocomotorybehaviormembranedepolarizationnervoussystemdevelopmentnervoussystemprocessregulationofacetylcholinesecretionneurotransmissionregulationofdendritemorphogenesisregulationofmembranepotentialregulationofsmoothmusclecontractionresponsetoacetylcholinesignaltransductionsynaptictransmissioninvolvedinmicturitionsynaptictransmissioncholinergicneuronalactionpotentialpositiveregulationoftransmissionofnerveimpulseregulationofneurotransmittersecretionsmoothmusclecontraction
Kinetochore protein Spc25
137
Kinetochore protein Spc24
111
7.9
57
0.22
SPC25SPC24Q9HBM1C9JGC4attachmentofspindlemicrotubulestokinetochorecelldivisionchromosomesegregationmitoticspindleassemblycheckpointsignalingmitoticspindleorganization
Voltage-dependent calcium channel gamma-3 subunit
589
Voltage-dependent calcium channel gamma-3 subunit
589
6.4
86
0.18
CCG3CCG3Q8VHX0Q8VHX0neurotransmitterreceptorinternalizationneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneneurotransmitterreceptortransportpostsynapticendosometolysosomepositiveregulationofAMPAreceptoractivitypositiveregulationofsynaptictransmissionglutamatergicpostsynapticneurotransmitterreceptordiffusiontrappingproteinlocalizationproteintargetingregulationofAMPAreceptoractivitytransmissionofnerveimpulse
Glial cell line-derived neurotrophic factor
118
Glial cell line-derived neurotrophic factor
178
9.1
55
0.2
GDNFGDNFP39905P39905adultlocomotorybehaviorbranchinginvolvedinuretericbudmorphogenesiscommissuralneuronaxonguidancedorsalspinalcorddevelopmentembryonicorgandevelopmententericnervoussystemdevelopmentmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesismetanephrosdevelopmentmRNAstabilizationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofneuronapoptoticprocessnervoussystemdevelopmentneuralcrestcellmigrationneuronprojectiondevelopmentorganinductionperipheralnervoussystemdevelopmentperistalsispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofdopaminesecretionpositiveregulationofmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesispositiveregulationofmonooxygenaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofuretericbudformationpostganglionicparasympatheticfiberdevelopmentpostsynapticmembraneorganizationregulationofdopamineuptakeinvolvedinsynaptictransmissionregulationofgeneexpressionregulationofmorphogenesisofabranchingstructureregulationofsemaphorin-plexinsignalingpathwayregulationofstemcelldifferentiationsignaltransductionsympatheticnervoussystemdevelopmenturetericbudformation
Glycoprotein hormones alpha chain
55
Thyrotropin subunit beta
22
9.0
66
0.17
GLHATSHBP01215P01222follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationanatomicalstructuremorphogenesiscell-cellsignalingresponsetocalciumionresponsetoestrogenresponsetovitaminA
Dipeptidyl aminopeptidase-like protein 6
107
Potassium voltage-gated channel subfamily D member 2
236
8.3
58
0.21
DPP6KCND2P42658Q9NZV8proteinlocalizationtoplasmamembraneproteolysisregulationofpotassiumiontransmembranetransportactionpotentialcellularresponsetohypoxiachemicalsynaptictransmissionlocomotorrhythmneuronalactionpotentialpotassiumiontransmembranetransportproteinhomooligomerizationregulationofiontransmembranetransportsensoryperceptionofpain
Immunoglobulin heavy constant alpha 1
182
Immunoglobulin heavy constant alpha 1
123
6.5
65
0.24
IGHA1IGHA1P01876P01876adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
Igh protein
478
Immunoglobulin J chain
34
8.2
68
0.18
Q99M22IGJQ99M22P01592adaptiveimmuneresponseantibacterialhumoralresponseglomerularfiltrationhumoralimmuneresponseinnateimmuneresponsepositiveregulationofrespiratoryburstprotein-containingcomplexassembly
Glycoprotein hormones alpha chain
31
Thyrotropin subunit beta
105
8.7
53
0.22
GLHATSHBP01215P01222follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationanatomicalstructuremorphogenesiscell-cellsignalingresponsetocalciumionresponsetoestrogenresponsetovitaminA
Glycoprotein hormones alpha chain
31
Thyrotropin subunit beta
72
8.6
64
0.18
GLHATSHBP01215P01222follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationanatomicalstructuremorphogenesiscell-cellsignalingresponsetocalciumionresponsetoestrogenresponsetovitaminA
DNA-directed RNA polymerase III subunit RPC2
924
DNA-directed RNA polymerases I, II, and III subunit RPABC5
10
8.3
99
0.12
RPC2RPAB5Q9NW08P62875defenseresponsetovirusinnateimmuneresponsepositiveregulationofinnateimmuneresponsepositiveregulationofinterferon-betaproductiontranscriptionDNA-templatedregulationoftranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseIItRNAtranscriptionbyRNApolymeraseIII
ER membrane protein complex subunit 5
57
ER membrane protein complex subunit 6
29
8.3
79
0.15
EMC5EMC6Q8N4V1Q9BV81copperiontransportmagnesiumiontransportproteininsertionintoERmembranebystop-transfermembrane-anchorsequencetail-anchoredmembraneproteininsertionintoERmembraneautophagosomeassembly
Glycoprotein hormones alpha chain
83
Choriogonadotropin subunit beta 3
113
8.5
77
0.15
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
Calcitonin gene-related peptide 1
84
Calcitonin gene-related peptide type 1 receptor
299
9.8
63
0.16
CALCACALRLP06881Q16602activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayamylinreceptorsignalingpathwayantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecalcitoningene-relatedpeptidereceptorsignalingpathwaycell-cellsignalingdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumendothelialcellmigrationendothelialcellproliferationGprotein-coupledreceptorinternalizationinnateimmuneresponseleukocytecell-celladhesionnegativeregulationofbloodpressurenegativeregulationofboneresorptionnegativeregulationofcalciumiontransportintocytosolnegativeregulationofosteoclastdifferentiationnervoussystemprocessinvolvedinregulationofsystemicarterialbloodpressurepositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofinterleukin-1alphaproductionpositiveregulationofinterleukin-8productionpositiveregulationofmacrophagedifferentiationproteinphosphorylationreceptorinternalizationregulationofbloodpressureregulationofcytosoliccalciumionconcentrationresponsetoyeastvasculaturedevelopmentvasodilationadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwayadrenomedullinreceptorsignalingpathwayangiogenesiscalciumiontransportcellsurfacereceptorsignalingpathwaycellularresponsetosucrosestimulusGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerheartdevelopmentnegativeregulationofinflammatoryresponsenegativeregulationofsmoothmusclecontractionpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteintransportvascularassociatedsmoothmusclecellproliferation
Extracellular calcium-sensing receptor
129
Extracellular calcium-sensing receptor
131
3.6
45
0.61
CASRCASRP41180P41180adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayanatomicalstructuremorphogenesisapoptoticprocessbileacidsecretionbranchingmorphogenesisofanepithelialtubecalciumionimportcellularcalciumionhomeostasiscellularresponsetoglucosestimuluscellularresponsetohepatocytegrowthfactorstimuluscellularresponsetohypoxiacellularresponsetolow-densitylipoproteinparticlestimuluscellularresponsetopeptidecellularresponsetovitaminDchemosensorybehaviorchloridetransmembranetransportdetectionofcalciumionfatpaddevelopmentGprotein-coupledreceptorsignalingpathwayJNKcascadeossificationphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofATP-dependentactivitypositiveregulationofcalciumionimportpositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofinsulinsecretionpositiveregulationofpositivechemotaxispositiveregulationofvasoconstrictionregulationofcalciumiontransportresponsetofibroblastgrowthfactorresponsetoischemiavasodilation
Mucin-2
1092
Mucin-2
1088
8.2
74
0.17
A0A0G2JR65A0A0G2JR65A0A0G2JR65A0A0G2JR65
Glycoprotein hormones alpha chain
83
Choriogonadotropin subunit beta 3
58
8.3
82
0.15
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
Glutamate receptor ionotropic, delta-1
351
Glutamate receptor ionotropic, delta-1
80
8.2
73
0.17
GRID1GRID1Q62640Q62640modulationofchemicalsynaptictransmissionsocialbehaviorsynaptictransmissionglutamatergic
Potassium voltage-gated channel subfamily C member 1
83
Potassium voltage-gated channel subfamily C member 1
78
8.6
76
0.15
KCNC1KCNC1P48547P48547cellularresponsetoxenobioticstimuluscerebellumdevelopmentglobuspallidusdevelopmentpositiveregulationofvoltage-gatedpotassiumchannelactivitypotassiumiontransmembranetransportpotassiumiontransportproteinhomooligomerizationproteintetramerizationresponsetoamineresponsetoauditorystimulusresponsetofibroblastgrowthfactorresponsetolightintensityresponsetonervegrowthfactorresponsetopotassiumionresponsetotoxicsubstance
ATP synthase F(0) complex subunit C1, mitochondrial
125
ATP synthase F(0) complex subunit C1, mitochondrial
125
8.6
89
0.13
AT5G1AT5G1P32876P32876protonmotiveforce-drivenATPsynthesis
Major prion protein
213
Major prion protein
178
8.6
79
0.15
PRIOPRIOP04925P04925activationofproteinkinaseactivitycalcium-mediatedsignalingusingintracellularcalciumsourcecellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocopperioncellularresponsetoxenobioticstimuluslearningormemorynegativeregulationofactivatedTcellproliferationnegativeregulationofamyloidprecursorproteincatabolicprocessnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofcalcineurin-NFATsignalingcascadenegativeregulationofcatalyticactivitynegativeregulationofdendriticspinemaintenancenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofinterferon-gammaproductionnegativeregulationofinterleukin-17productionnegativeregulationofinterleukin-2productionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofproteinphosphorylationnegativeregulationofTcellreceptorsignalingpathwayneuronprojectionmaintenancenucleobase-containingcompoundmetabolicprocesspositiveregulationofcelldeathpositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteintargetingtomembranepositiveregulationofproteintyrosinekinaseactivityproteindestabilizationproteinhomooligomerizationregulationofcalciumionimportacrossplasmamembraneregulationofglutamatereceptorsignalingpathwayregulationofintracellularcalciumactivatedchloridechannelactivityregulationofpeptidyl-tyrosinephosphorylationregulationofpotassiumiontransmembranetransportregulationofproteinlocalizationresponsetoamyloid-betaresponsetocadmiumionresponsetocopperionresponsetooxidativestress
Microtubule-associated protein tau
639
Microtubule-associated protein tau
639
6.6
52
0.29
TAUTAUP10636P10636activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessamyloidfibrilformationastrocyteactivationaxondevelopmentaxonaltransportaxonaltransportofmitochondrioncell-cellsignalingcellularresponsetobrain-derivedneurotrophicfactorstimuluscellularresponsetoheatcellularresponsetonervegrowthfactorstimuluscellularresponsetoreactiveoxygenspeciescentralnervoussystemneurondevelopmentcytoplasmicmicrotubuleorganizationgenerationofneuronsinternalproteinaminoacidacetylationintracellulardistributionofmitochondrialearningormemorymemorymicroglialcellactivationmicrotubulecytoskeletonorganizationmicrotubulepolymerizationnegativeregulationofestablishmentofproteinlocalizationtomitochondrionnegativeregulationofgeneexpressionnegativeregulationofkinaseactivitynegativeregulationofmitochondrialfissionnegativeregulationofmitochondrialmembranepotentialnegativeregulationoftubulindeacetylationneurofibrillarytangleassemblyneuronprojectiondevelopmentplus-end-directedorganelletransportalongmicrotubulepositiveregulationofaxonextensionpositiveregulationofdiacylglycerolkinaseactivitypositiveregulationofmicrotubulepolymerizationpositiveregulationofneurondeathpositiveregulationofproteinlocalizationpositiveregulationofproteinlocalizationtosynapsepositiveregulationofsuperoxideaniongenerationproteinhomooligomerizationproteinpolymerizationregulationofautophagyregulationofcalcium-mediatedsignalingregulationofcellularresponsetoheatregulationofchromosomeorganizationregulationoflong-termsynapticdepressionregulationofmicrotubulecytoskeletonorganizationregulationofmicrotubulepolymerizationregulationofmicrotubulepolymerizationordepolymerizationregulationofmitochondrialfissionregulationofresponsetoDNAdamagestimulusregulationofsynapticplasticityresponsetoleadionrRNAmetabolicprocessstressgranuleassemblysupramolecularfiberorganizationsynapseassemblysynapseorganization
Insulin receptor
712
Insulin receptor
712
9.6
21
0.5
INSRINSRP15208P15208activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearanceanimalorganmorphogenesiscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaymalegonaddevelopmentmalesexdeterminationnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofproteinphosphorylationnegativeregulationoftransporteractivityneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationofhydrogenperoxidemetabolicprocessregulationoftranscriptionDNA-templatedresponsetonutrientlevelsresponsetotumornecrosisfactortransmembranereceptorproteintyrosinekinasesignalingpathwayviralentryintohostcell
Major prion protein
179
Major prion protein
179
4.8
57
0.36
PRIOPRIOP04156P04156activationofproteinkinaseactivitycalcium-mediatedsignalingusingintracellularcalciumsourcecellcyclecellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocopperioncellularresponsetoxenobioticstimulusdendriticspinemaintenancelearningormemorylong-termmemorynegativeregulationofactivatedTcellproliferationnegativeregulationofamyloidprecursorproteincatabolicprocessnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofcalcineurin-NFATsignalingcascadenegativeregulationofdendriticspinemaintenancenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofinterferon-gammaproductionnegativeregulationofinterleukin-17productionnegativeregulationofinterleukin-2productionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofproteinphosphorylationnegativeregulationofproteinprocessingnegativeregulationofTcellreceptorsignalingpathwayneuronprojectionmaintenancepositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteintargetingtomembranepositiveregulationofproteintyrosinekinaseactivityproteindestabilizationproteinhomooligomerizationregulationofcalciumionimportacrossplasmamembraneregulationofglutamatereceptorsignalingpathwayregulationofintracellularcalciumactivatedchloridechannelactivityregulationofpeptidyl-tyrosinephosphorylationregulationofpotassiumiontransmembranetransportresponsetoamyloid-betaresponsetocadmiumionresponsetooxidativestress
Immunoglobulin heavy constant alpha 2
167
Immunoglobulin heavy constant alpha 2
167
8.3
42
0.29
IGHA2IGHA2P01877P01877adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
194
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
152
8.6
97
0.12
NDUS7NDUS8Q9DC70Q8K3J1aerobicrespirationelectrontransportcoupledprotontransportmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyprotonmotiveforce-drivenmitochondrialATPsynthesisresponsetooxidativestress
Two pore channel protein 2
450
Two pore channel protein 2
228
8.6
56
0.21
TPC2TPC2Q8NHX9Q8NHX9calcium-mediatedsignalingcellularcalciumionhomeostasisendocytosisinvolvedinviralentryintohostcellendosometolysosometransportoflow-densitylipoproteinparticleiontransmembranetransportlysosomeorganizationreceptor-mediatedendocytosisofvirusbyhostcellregulationofautophagyregulationofexocytosisregulationofiontransmembranetransportresponsetovitaminDsmoothmusclecontractionsodiumiontransmembranetransport
DNA-directed RNA polymerase III subunit RPC2
924
DNA-directed RNA polymerases I, II, and III subunit RPABC5
44
8.3
92
0.13
RPC2RPAB5Q9NW08P62875defenseresponsetovirusinnateimmuneresponsepositiveregulationofinnateimmuneresponsepositiveregulationofinterferon-betaproductiontranscriptionDNA-templatedregulationoftranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseIItRNAtranscriptionbyRNApolymeraseIII
Insulin receptor
711
Insulin receptor
712
7.6
nan
nan
INSRINSRP15208P15208activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearanceanimalorganmorphogenesiscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaymalegonaddevelopmentmalesexdeterminationnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofproteinphosphorylationnegativeregulationoftransporteractivityneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationofhydrogenperoxidemetabolicprocessregulationoftranscriptionDNA-templatedresponsetonutrientlevelsresponsetotumornecrosisfactortransmembranereceptorproteintyrosinekinasesignalingpathwayviralentryintohostcell
Protein inturned
838
Protein fuzzy homolog
365
9.2
82
0.13
INTUFUZZYQ9ULD6Q9BT04celldivisionciliumassemblyembryonicdigitmorphogenesisestablishmentofplanarpolarityhairfolliclemorphogenesisintraciliarytransportkeratinocytedifferentiationlimbdevelopmentmotileciliumassemblynegativeregulationofcelldivisionnegativeregulationofkeratinocyteproliferationnervoussystemdevelopmentneuraltubedevelopmentnon-motileciliumassemblypositiveregulationofsmoothenedsignalingpathwayproteinlocalizationtoorganelleregulationofciliumassemblyregulationofossificationregulationofsmoothenedsignalingpathwayroofofmouthdevelopmentsmoothenedsignalingpathwayspinalcorddorsal/ventralpatterningtonguemorphogenesisvesicle-mediatedtransportembryonicbodymorphogenesisembryonicskeletalsystemmorphogenesishairfollicledevelopmentnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationoffibroblastgrowthfactorreceptorsignalingpathwayinvolvedinneuralplateanterior/posteriorpatternformationnegativeregulationofneuralcrestformationneuraltubeclosurepositiveregulationofciliumassemblyproteintransport
Glutamate receptor 1
75
Glutamate receptor
78
8.5
70
0.17
GRIA1G5E8H1P23818G5E8H1cellularresponsetoammoniumionchemicalsynaptictransmissionlong-termmemorylong-termsynapticdepressionmodulationofchemicalsynaptictransmissionneuronalactionpotentialpositiveregulationofmembranepotentialpositiveregulationofsynaptictransmissionreceptorinternalizationregulationofpostsynapticmembranepotentialregulationofreceptorrecyclingregulationofsynapticplasticityresponsetotoxicsubstance
Mas-related G-protein coupled receptor member X2
180
Cortistatin
93
4.4
52
0.44
MRGX2CORTQ96LB1O00230Gprotein-coupledreceptorsignalingpathwaymastcellactivationmastcelldegranulationpositiveregulationofcytokinesissensoryperceptionofpainsleepadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaychemicalsynaptictransmissionreplicationforkprocessingresolutionofmeioticrecombinationintermediates
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
382
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
75
8.5
85
0.14
NDUV1NDUS1P25708P15690mitochondrialelectrontransportNADHtoubiquinoneapoptoticmitochondrialchangesATPmetabolicprocesscellularrespirationmitochondrialrespiratorychaincomplexIassemblyreactiveoxygenspeciesmetabolicprocessregulationofmitochondrialmembranepotential
Clathrin heavy chain 1
1565
Clathrin light chain B
198
8.6
63
0.18
CLH1CLCBP49951P04975amyloid-betaclearancebytranscytosisautophagycelldivisionclathrincoatassemblyclathrin-dependentendocytosisintracellularproteintransportmitoticcellcyclenegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofproteinlocalizationtoplasmamembranereceptorinternalizationreceptor-mediatedendocytosisregulationofmitoticspindleorganizationretrogradetransportendosometoGolgitransferrintransport
Zinc transporter 8
361
Zinc transporter 8
53
9.2
nan
nan
ZNT8ZNT8Q8IWU4Q8IWU4cellularzincionhomeostasisinsulinprocessinginsulinsecretionpositiveregulationofinsulinsecretionregulationofsequesteringofzincionregulationofvesicle-mediatedtransportresponsetoglucoseresponsetointerferon-gammaresponsetointerleukin-1responsetozincionsequesteringofzincionzinciontransmembranetransportzinciontransport
Insulin-like growth factor 1 receptor
703
Insulin-like growth factor 1 receptor
703
9.4
31
0.34
IGF1RIGF1RQ60751Q60751adrenalglanddevelopmentamyloid-betaclearanceanimalorganmorphogenesisaxonogenesisbraindevelopmentcellularresponsetoamyloid-betacellularresponsetoglucosestimuluscellularresponsetoinsulinstimuluscellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetotransforminggrowthfactorbetastimuluscerebellumdevelopmentdendriticspinemaintenanceepidermisdevelopmentestablishmentofcellpolarityestrouscycleexocrinepancreasdevelopmentglucosehomeostasisimmuneresponseinsulinreceptorsignalingpathwayinsulin-likegrowthfactorreceptorsignalingpathwaymalesexdeterminationmammaryglanddevelopmentMAPKcascademitoticnucleardivisionnegativeregulationofapoptoticprocessnegativeregulationofcholangiocyteapoptoticprocessnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofhepatocyteapoptoticprocessnegativeregulationofMAPKcascadenegativeregulationofmusclecellapoptoticprocessnegativeregulationofproteinkinaseBsignalingneuronprojectiondevelopmentpeptidyl-tyrosineautophosphorylationphosphatidylinositol-mediatedsignalingpositiveregulationofaxonregenerationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcold-inducedthermogenesispositiveregulationofcytokinesispositiveregulationofdevelopmentalgrowthpositiveregulationofDNAmetabolicprocesspositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastproliferationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsteroidhormonebiosyntheticprocesspositiveregulationoftranscriptionDNA-templatedprostateglandepitheliummorphogenesisproteinautophosphorylationproteinkinaseBsignalingproteinphosphorylationregulationofJNKcascaderesponsetoethanolresponsetoL-glutamatetranscytosistransmembranereceptorproteintyrosinekinasesignalingpathway
Insulin-like growth factor 1 receptor
702
Insulin-like growth factor 1 receptor
700
9.2
nan
nan
IGF1RIGF1RP08069P08069agingamyloid-betaclearanceaxonogenesiscardiacatriumdevelopmentcellularresponsetoaldosteronecellularresponsetoamyloid-betacellularresponsetoangiotensincellularresponsetodexamethasonestimuluscellularresponsetoestradiolstimuluscellularresponsetoglucosestimuluscellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetomechanicalstimuluscellularresponsetoprogesteronestimuluscellularresponsetotestosteronestimuluscellularresponsetotransforminggrowthfactorbetastimuluscellularsenescencecerebellumdevelopmentdendriticspinemaintenanceestablishmentofcellpolarityestrouscycleglucosehomeostasishippocampusdevelopmentimmuneresponseinsulinreceptorsignalingpathwayinsulin-likegrowthfactorreceptorsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofcholangiocyteapoptoticprocessnegativeregulationofhepatocyteapoptoticprocessnegativeregulationofMAPKcascadenegativeregulationofmusclecellapoptoticprocesspeptidyl-tyrosineautophosphorylationphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofaxonregenerationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcold-inducedthermogenesispositiveregulationofcytokinesispositiveregulationofDNAmetabolicprocesspositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofosteoblastproliferationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsteroidhormonebiosyntheticprocessproteinautophosphorylationregulationofJNKcascaderesponsetoethanolresponsetoL-glutamateresponsetonicotineresponsetovitaminEsignaltransductiontranscytosistransmembranereceptorproteintyrosinekinasesignalingpathway
Transmembrane protein 106B
253
Transmembrane protein 106B
253
9.8
59
0.17
T106BT106BQ9NUM4Q9NUM4dendritemorphogenesislysosomallumenacidificationlysosomalproteincatabolicprocesslysosomaltransportlysosomelocalizationlysosomeorganizationneuroncellularhomeostasispositiveregulationofdendritedevelopmentpositiveregulationofhydrolaseactivityregulationoflysosomeorganization
Glycoprotein hormones alpha chain
31
Thyrotropin subunit beta
22
8.4
49
0.24
GLHATSHBP01215P01222follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationanatomicalstructuremorphogenesiscell-cellsignalingresponsetocalciumionresponsetoestrogenresponsetovitaminA
Immunoglobulin heavy constant alpha 2
110
Immunoglobulin heavy constant alpha 2
110
9.9
nan
nan
IGHA2IGHA2P01877P01877adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
225
8.3
97
0.12
F1RVN1A0A287BG40F1RVN1A0A287BG40mitochondrialelectrontransportNADHtoubiquinonecardiacmuscletissuedevelopmentnervoussystemdevelopment
Insulin receptor
714
Insulin receptor
714
9.9
29
0.35
INSRINSRP15208P15208activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearanceanimalorganmorphogenesiscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaymalegonaddevelopmentmalesexdeterminationnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofproteinphosphorylationnegativeregulationoftransporteractivityneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationofhydrogenperoxidemetabolicprocessregulationoftranscriptionDNA-templatedresponsetonutrientlevelsresponsetotumornecrosisfactortransmembranereceptorproteintyrosinekinasesignalingpathwayviralentryintohostcell
Mucin-2
1090
Mucin-2
1088
8.6
79
0.15
A0A0G2JR65A0A0G2JR65A0A0G2JR65A0A0G2JR65
Gap junction gamma-3 protein
2
Gap junction gamma-3 protein
2
6.0
nan
nan
CXG3CXG3Q8NFK1Q8NFK1cell-cellsignalingmyelinationsensoryperceptionofsound
Calcium homeostasis modulator protein 2
48
Calcium homeostasis modulator protein 2
179
9.9
81
0.12
CAHM2CAHM2Q9HA72Q9HA72positiveregulationofapoptoticprocess
P2X purinoceptor 7
363
P2X purinoceptor 7
4
8.6
nan
nan
P2RX7P2RX7Q64663Q64663apoptoticsignalingpathwayATPexportblebassemblycalciumiontransportcationtransportcelldeathcellmorphogenesiscellsurfacereceptorsignalingpathwaycellvolumehomeostasiscellularresponsetodsRNAcellularresponsetoextracellularstimuluscellularresponsetoorganiccycliccompoundceramidebiosyntheticprocesscollagenmetabolicprocessdefenseresponsetoGram-positivebacteriumextrinsicapoptoticsignalingpathwaygeneexpressionhomeostasisofnumberofcellswithinatissueinflammatoryresponsemembranedepolarizationmembraneproteinectodomainproteolysismitochondrionorganizationNADtransportnegativeregulationofboneresorptionnegativeregulationofcellvolumenegativeregulationofMAPKcascadeneuronalactionpotentialorganiccationtransportphagolysosomeassemblyphospholipidtransfertomembranephospholipidtranslocationplasmamembraneorganizationplasmamembranephospholipidscramblingporecomplexassemblypositiveregulationofapoptoticprocesspositiveregulationofblebassemblypositiveregulationofbonemineralizationpositiveregulationofcalciumiontransportintocytosolpositiveregulationofcatalyticactivitypositiveregulationofcytokineproductionpositiveregulationofcytoskeletonorganizationpositiveregulationofgamma-aminobutyricacidsecretionpositiveregulationofgeneexpressionpositiveregulationofglutamatesecretionpositiveregulationofglycolyticprocesspositiveregulationofinterleukin-1alphaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofiontransmembranetransportpositiveregulationoflymphocyteapoptoticprocesspositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmitochondrialdepolarizationpositiveregulationofossificationpositiveregulationofprostaglandinsecretionpositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofTcellmediatedcytotoxicityprogrammedcelldeathproteincatabolicprocessproteinphosphorylationproteinprocessingpurinergicnucleotidereceptorsignalingpathwayreactiveoxygenspeciesmetabolicprocessregulationofpresynapticdensecoregranuleexocytosisregulationofsodiumiontransportreleaseofsequesteredcalciumionintocytosolresponsetoATPresponsetobacteriumresponsetocalciumionresponsetoelectricalstimulusresponsetofluidshearstressresponsetolipopolysaccharideresponsetomechanicalstimulusresponsetoorganiccycliccompoundresponsetoorganicsubstanceresponsetoxenobioticstimulusresponsetozincionsensoryperceptionofpainskeletalsystemmorphogenesissynapticvesicleexocytosisTcellhomeostasisTcellproliferationvesiclebuddingfrommembrane
Calcium homeostasis modulator protein 4
83
Calcium homeostasis modulator protein 4
210
8.4
nan
nan
CAHM4CAHM4Q5JW98Q5JW98
Immunoglobulin heavy constant alpha 1
180
Immunoglobulin heavy constant alpha 1
122
3.8
nan
nan
IGHA1IGHA1P01876P01876adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
Ion channel TACAN
12
Ion channel TACAN
68
5.3
41
0.46
TACANTACANQ9BXJ8Q9BXJ8detectionofmechanicalstimulusinvolvedinsensoryperceptionofpainfatcelldifferentiationiontransmembranetransportproteinheterooligomerizationproteinhomooligomerization
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
95
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
95
8.3
83
0.14
ISCUISCUQ9H1K1Q9H1K1cellularironionhomeostasisiron-sulfurclusterassemblynegativeregulationofironionimportacrossplasmamembranepositiveregulationofaconitatehydrataseactivitypositiveregulationofmitochondrialelectrontransportNADHtoubiquinone
Calcium homeostasis modulator protein 2
48
Calcium homeostasis modulator protein 2
180
9.5
77
0.14
CAHM2CAHM2Q9HA72Q9HA72positiveregulationofapoptoticprocess
Calcium homeostasis modulator protein 6
82
Calcium homeostasis modulator protein 6
198
3.9
nan
nan
CAHM6CAHM6Q5R3K3Q5R3K3
Insulin-like growth factor 1 receptor
545
Insulin-like growth factor 1 receptor
545
9.6
nan
nan
IGF1RIGF1RQ60751Q60751adrenalglanddevelopmentamyloid-betaclearanceanimalorganmorphogenesisaxonogenesisbraindevelopmentcellularresponsetoamyloid-betacellularresponsetoglucosestimuluscellularresponsetoinsulinstimuluscellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetotransforminggrowthfactorbetastimuluscerebellumdevelopmentdendriticspinemaintenanceepidermisdevelopmentestablishmentofcellpolarityestrouscycleexocrinepancreasdevelopmentglucosehomeostasisimmuneresponseinsulinreceptorsignalingpathwayinsulin-likegrowthfactorreceptorsignalingpathwaymalesexdeterminationmammaryglanddevelopmentMAPKcascademitoticnucleardivisionnegativeregulationofapoptoticprocessnegativeregulationofcholangiocyteapoptoticprocessnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofhepatocyteapoptoticprocessnegativeregulationofMAPKcascadenegativeregulationofmusclecellapoptoticprocessnegativeregulationofproteinkinaseBsignalingneuronprojectiondevelopmentpeptidyl-tyrosineautophosphorylationphosphatidylinositol-mediatedsignalingpositiveregulationofaxonregenerationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcold-inducedthermogenesispositiveregulationofcytokinesispositiveregulationofdevelopmentalgrowthpositiveregulationofDNAmetabolicprocesspositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastproliferationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsteroidhormonebiosyntheticprocesspositiveregulationoftranscriptionDNA-templatedprostateglandepitheliummorphogenesisproteinautophosphorylationproteinkinaseBsignalingproteinphosphorylationregulationofJNKcascaderesponsetoethanolresponsetoL-glutamatetranscytosistransmembranereceptorproteintyrosinekinasesignalingpathway
Mas-related G-protein coupled receptor member X2
168
Cortistatin
93
5.7
57
0.31
MRGX2CORTQ96LB1O00230Gprotein-coupledreceptorsignalingpathwaymastcellactivationmastcelldegranulationpositiveregulationofcytokinesissensoryperceptionofpainsleepadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaychemicalsynaptictransmissionreplicationforkprocessingresolutionofmeioticrecombinationintermediates
Glycoprotein hormones alpha chain
55
Thyrotropin subunit beta
105
8.5
72
0.16
GLHATSHBP01215P01222follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationanatomicalstructuremorphogenesiscell-cellsignalingresponsetocalciumionresponsetoestrogenresponsetovitaminA
General transcription and DNA repair factor IIH helicase subunit XPD
588
General transcription factor IIH subunit 2
177
8.5
62
0.19
ERCC2TF2H2P18074Q13888agingapoptoticprocessbonemineralizationcentralnervoussystemmyelinformationchromosomesegregationembryoniccleavageerythrocytematurationextracellularmatrixorganizationhaircelldifferentiationhairfolliclematurationhematopoieticstemcelldifferentiationhematopoieticstemcellproliferationinuteroembryonicdevelopmentmaturationofSSU-rRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)multicellularorganismgrowthnucleotide-excisionrepairnucleotide-excisionrepairDNAduplexunwindingnucleotide-excisionrepairDNAincisionpositiveregulationofDNAbindingpositiveregulationofmitoticrecombinationpost-embryonicdevelopmentregulationofmitoticcellcyclephasetransitionresponsetooxidativestressspinalcorddevelopmenttranscriptionbyRNApolymeraseIItranscriptionelongationfromRNApolymeraseIpromotertranscription-couplednucleotide-excisionrepairUVprotectionGprotein-coupledreceptorinternalizationpositiveregulationofDNAhelicaseactivityregulationoftranscriptionbyRNApolymeraseIIresponsetoUVtranscriptioninitiationfromRNApolymeraseIIpromoter
Immunoglobulin heavy constant alpha 1
182
Immunoglobulin heavy constant alpha 1
122
3.9
nan
nan
IGHA1IGHA1P01876P01876adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
Muscarinic acetylcholine receptor M4
456
8.5
62
0.19
GNAI1ACM4P63096P08173adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormoneadenylatecyclase-inhibitingGprotein-coupledacetylcholinereceptorsignalingpathwaycellsurfacereceptorsignalingpathwaychemicalsynaptictransmissionGprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerregulationoflocomotionsignaltransduction
ATP synthase F(0) complex subunit C1, mitochondrial
125
ATP synthase F(0) complex subunit C1, mitochondrial
125
8.5
94
0.13
AT5G1AT5G1P17605P17605protonmotiveforce-drivenATPsynthesis
Microtubule-associated protein tau
608
Microtubule-associated protein tau
608
4.7
25
0.85
TAUTAUP10636P10636activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessamyloidfibrilformationastrocyteactivationaxondevelopmentaxonaltransportaxonaltransportofmitochondrioncell-cellsignalingcellularresponsetobrain-derivedneurotrophicfactorstimuluscellularresponsetoheatcellularresponsetonervegrowthfactorstimuluscellularresponsetoreactiveoxygenspeciescentralnervoussystemneurondevelopmentcytoplasmicmicrotubuleorganizationgenerationofneuronsinternalproteinaminoacidacetylationintracellulardistributionofmitochondrialearningormemorymemorymicroglialcellactivationmicrotubulecytoskeletonorganizationmicrotubulepolymerizationnegativeregulationofestablishmentofproteinlocalizationtomitochondrionnegativeregulationofgeneexpressionnegativeregulationofkinaseactivitynegativeregulationofmitochondrialfissionnegativeregulationofmitochondrialmembranepotentialnegativeregulationoftubulindeacetylationneurofibrillarytangleassemblyneuronprojectiondevelopmentplus-end-directedorganelletransportalongmicrotubulepositiveregulationofaxonextensionpositiveregulationofdiacylglycerolkinaseactivitypositiveregulationofmicrotubulepolymerizationpositiveregulationofneurondeathpositiveregulationofproteinlocalizationpositiveregulationofproteinlocalizationtosynapsepositiveregulationofsuperoxideaniongenerationproteinhomooligomerizationproteinpolymerizationregulationofautophagyregulationofcalcium-mediatedsignalingregulationofcellularresponsetoheatregulationofchromosomeorganizationregulationoflong-termsynapticdepressionregulationofmicrotubulecytoskeletonorganizationregulationofmicrotubulepolymerizationregulationofmicrotubulepolymerizationordepolymerizationregulationofmitochondrialfissionregulationofresponsetoDNAdamagestimulusregulationofsynapticplasticityresponsetoleadionrRNAmetabolicprocessstressgranuleassemblysupramolecularfiberorganizationsynapseassemblysynapseorganization
Islet amyloid polypeptide
40
Islet amyloid polypeptide
40
4.9
61
0.34
IAPPIAPPP10997P10997adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayamylinreceptorsignalingpathwayamyloidfibrilformationapoptoticprocessboneresorptioncell-cellsignalingeatingbehaviornegativeregulationofamyloidfibrilformationnegativeregulationofboneresorptionnegativeregulationofcellpopulationproliferationnegativeregulationofmitochondrionorganizationnegativeregulationofosteoclastdifferentiationnegativeregulationofprotein-containingcomplexassemblyosteoclastdifferentiationpositiveregulationofapoptoticprocesspositiveregulationofcalciumionimportacrossplasmamembranepositiveregulationofcelldeathpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofMAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingproteindestabilizationproteinhomooligomerizationsensoryperceptionofpainsignaltransduction
DNA-directed RNA polymerase III subunit RPC2
924
DNA-directed RNA polymerases I, II, and III subunit RPABC5
7
8.5
97
0.12
RPC2RPAB5Q9NW08P62875defenseresponsetovirusinnateimmuneresponsepositiveregulationofinnateimmuneresponsepositiveregulationofinterferon-betaproductiontranscriptionDNA-templatedregulationoftranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseIItRNAtranscriptionbyRNApolymeraseIII
DNA polymerase delta catalytic subunit
1011
Proliferating cell nuclear antigen
27
8.5
63
0.19
DPOD1PCNAP28340P12004base-excisionrepairgap-fillingcellularresponsetoUVDNAbiosyntheticprocessDNArepairDNAreplicationDNAreplicationproofreadingDNAsynthesisinvolvedinDNArepairDNA-templatedDNAreplicationerror-freetranslesionsynthesisfattyacidhomeostasisnucleotide-excisionrepairDNAgapfillingresponsetoUVcellularresponsetohydrogenperoxidecellularresponsetoxenobioticstimulusepithelialcelldifferentiationestrouscycleheartdevelopmentleadingstrandelongationliverregenerationmismatchrepairmitotictelomeremaintenanceviasemi-conservativereplicationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofdeoxyribonucleaseactivitypositiveregulationofDNArepairpositiveregulationofDNAreplicationpositiveregulationofDNA-directedDNApolymeraseactivityreplicationforkprocessingresponsetocadmiumionresponsetodexamethasoneresponsetoestradiolresponsetoL-glutamatetranslesionsynthesis
Igh protein
249
Igh protein
249
9.8
nan
nan
Q99M22Q99M22Q99M22Q99M22
TMEM106B protein
293
TMEM106B protein
293
4.8
55
0.38
Q8N353Q8N353Q8N353Q8N353
Extracellular calcium-sensing receptor
131
Extracellular calcium-sensing receptor
131
3.7
nan
nan
CASRCASRP41180P41180adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayanatomicalstructuremorphogenesisapoptoticprocessbileacidsecretionbranchingmorphogenesisofanepithelialtubecalciumionimportcellularcalciumionhomeostasiscellularresponsetoglucosestimuluscellularresponsetohepatocytegrowthfactorstimuluscellularresponsetohypoxiacellularresponsetolow-densitylipoproteinparticlestimuluscellularresponsetopeptidecellularresponsetovitaminDchemosensorybehaviorchloridetransmembranetransportdetectionofcalciumionfatpaddevelopmentGprotein-coupledreceptorsignalingpathwayJNKcascadeossificationphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofATP-dependentactivitypositiveregulationofcalciumionimportpositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofinsulinsecretionpositiveregulationofpositivechemotaxispositiveregulationofvasoconstrictionregulationofcalciumiontransportresponsetofibroblastgrowthfactorresponsetoischemiavasodilation
Calcitonin gene-related peptide 1
89
Calcitonin gene-related peptide type 1 receptor
299
8.4
78
0.15
CALCACALRLP06881Q16602activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayamylinreceptorsignalingpathwayantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecalcitoningene-relatedpeptidereceptorsignalingpathwaycell-cellsignalingdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumendothelialcellmigrationendothelialcellproliferationGprotein-coupledreceptorinternalizationinnateimmuneresponseleukocytecell-celladhesionnegativeregulationofbloodpressurenegativeregulationofboneresorptionnegativeregulationofcalciumiontransportintocytosolnegativeregulationofosteoclastdifferentiationnervoussystemprocessinvolvedinregulationofsystemicarterialbloodpressurepositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofinterleukin-1alphaproductionpositiveregulationofinterleukin-8productionpositiveregulationofmacrophagedifferentiationproteinphosphorylationreceptorinternalizationregulationofbloodpressureregulationofcytosoliccalciumionconcentrationresponsetoyeastvasculaturedevelopmentvasodilationadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwayadrenomedullinreceptorsignalingpathwayangiogenesiscalciumiontransportcellsurfacereceptorsignalingpathwaycellularresponsetosucrosestimulusGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerheartdevelopmentnegativeregulationofinflammatoryresponsenegativeregulationofsmoothmusclecontractionpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteintransportvascularassociatedsmoothmusclecellproliferation
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
175
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
8.3
89
0.13
NDUV2NDUV1Q9D6J6Q91YT0aerobicrespirationcardiacmuscletissuedevelopmentmitochondrialelectrontransportNADHtoubiquinonenervoussystemdevelopmentprotonmotiveforce-drivenmitochondrialATPsynthesismitochondrialATPsynthesiscoupledelectrontransport
Glutamate receptor ionotropic, kainate 3
350
Glutamate receptor ionotropic, kainate 3
350
7.9
57
0.22
GRIK3GRIK3P42264P42264chemicalsynaptictransmissionGprotein-coupledglutamatereceptorsignalingpathwayglutamatereceptorsignalingpathwaymodulationofchemicalsynaptictransmissionnegativeregulationofsynaptictransmissionglutamatergicregulationofmembranepotentialsynaptictransmissionglutamatergic
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
286
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
222
8.4
97
0.12
W5PUX0W5NRY1W5PUX0W5NRY1mitochondrialATPsynthesiscoupledelectrontransport
C-C motif chemokine 15
53
C-C chemokine receptor type 1
24
8.4
65
0.18
CCL15CCR1Q16663P32246cell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitysignaltransductioncalciumiontransportcalcium-mediatedsignalingcelladhesioncellchemotaxiscellsurfacereceptorsignalingpathwaycytokine-mediatedsignalingpathwaydendriticcellchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerimmuneresponsenegativeregulationofbonemineralizationnegativeregulationofgeneexpressionpositiveregulationofcalciumiontransportpositiveregulationofcellmigrationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofmonocytechemotaxispositiveregulationofosteoclastdifferentiationresponsetowounding
Superoxide dismutase [Cu-Zn]
7
Superoxide dismutase [Cu-Zn]
7
9.9
57
0.18
SODCSODCP00441P00441aginganterogradeaxonaltransportapoptoticprocessauditoryreceptorcellstereociliumorganizationcellularironionhomeostasiscellularresponsetoATPcellularresponsetocadmiumioncellularresponsetopotassiumionectopicgermcellprogrammedcelldeathembryoimplantationglutathionemetabolicprocessheartcontractionhydrogenperoxidebiosyntheticprocesslocomotorybehaviormusclecellcellularhomeostasismyeloidcellhomeostasisnegativeregulationofcholesterolbiosyntheticprocessnegativeregulationofdevelopmentalprocessnegativeregulationofinflammatoryresponsenegativeregulationofneuronapoptoticprocessnegativeregulationofreproductiveprocessneurofilamentcytoskeletonorganizationovarianfollicledevelopmentperipheralnervoussystemmyelinmaintenanceplacentadevelopmentpositiveregulationofapoptoticprocesspositiveregulationofcatalyticactivitypositiveregulationofcytokineproductionpositiveregulationofMAPKcascadepositiveregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaypositiveregulationofphagocytosispositiveregulationofsuperoxideaniongenerationreactiveoxygenspeciesmetabolicprocessregulationofbloodpressureregulationofGTPaseactivityregulationofmitochondrialmembranepotentialregulationofmulticellularorganismgrowthregulationoforgangrowthregulationofproteinkinaseactivityregulationofTcelldifferentiationinthymusrelaxationofvascularassociatedsmoothmuscleremovalofsuperoxideradicalsresponsetoamphetamineresponsetoantibioticresponsetoantipsychoticdrugresponsetoaxoninjuryresponsetocarbonmonoxideresponsetocopperionresponsetoethanolresponsetoheatresponsetohydrogenperoxideresponsetonutrientlevelsresponsetoorganicsubstanceresponsetosuperoxideresponsetoxenobioticstimulusretinahomeostasisretrogradeaxonaltransportsensoryperceptionofsoundspermatogenesissuperoxideaniongenerationsuperoxidemetabolicprocessthymusdevelopmenttransmissionofnerveimpulse
Immunoglobulin heavy constant alpha 1
123
Immunoglobulin heavy constant alpha 1
123
9.2
nan
nan
IGHA1IGHA1P01876P01876adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
cAMP-dependent protein kinase catalytic subunit alpha
200
cAMP-dependent protein kinase type II-beta regulatory subunit
114
8.4
66
0.18
KAPCAKAP3P17612P12369calcium-mediatedsignalingusingintracellularcalciumsourcecellcommunicationbyelectricalcouplinginvolvedincardiacconductioncellularresponsetocoldcellularresponsetoepinephrinestimuluscellularresponsetoglucosestimuluscellularresponsetoheatcellularresponsetoparathyroidhormonestimuluscytokine-mediatedsignalingpathwayhigh-densitylipoproteinparticleassemblymesodermformationmodulationofchemicalsynaptictransmissionmRNAprocessingnegativeregulationofsmoothenedsignalingpathwayinvolvedindorsal/ventralneuraltubepatterningneuraltubeclosurepeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofproteinexportfromnucleusproteinautophosphorylationproteinexportfromnucleusproteinkinaseAsignalingproteinlocalizationtolipiddropletproteinphosphorylationregulationofbicellulartightjunctionassemblyregulationofcardiacconductionregulationofcardiacmusclecontractionregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofcellcycleregulationofcytosoliccalciumionconcentrationregulationofheartrateregulationofmacroautophagyregulationofosteoblastdifferentiationregulationofproteasomalproteincatabolicprocessregulationofproteinbindingregulationofproteinprocessingregulationofryanodine-sensitivecalcium-releasechannelactivityrenalwaterhomeostasisspermcapacitationfattyacidmetabolicprocesslearningnegativeregulationofcAMP-dependentproteinkinaseactivityregulationofproteinkinaseactivityresponsetoantipsychoticdrugresponsetoclozapine
Immunoglobulin heavy constant alpha 1
123
Immunoglobulin heavy constant alpha 1
122
8.3
nan
nan
IGHA1IGHA1P01876P01876adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
478
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
478
8.3
94
0.13
HCN4HCN4Q9Y3Q4Q9Y3Q4bloodcirculationcationtransportcellularresponsetocAMPcellularresponsetocGMPmembranedepolarizationduringcardiacmusclecellactionpotentialmembranedepolarizationduringSAnodecellactionpotentialmusclecontractionpotassiumionimportacrossplasmamembranepotassiumiontransmembranetransportregulationofcardiacmusclecellactionpotentialinvolvedinregulationofcontractionregulationofcardiacmusclecontractionregulationofcationchannelactivityregulationofheartrateregulationofheartratebycardiacconductionregulationofmembranedepolarizationregulationofmembranepotentialregulationofSAnodecellactionpotentialSAnodecellactionpotentialsinoatrialnodedevelopmentsodiumionimportacrossplasmamembranesodiumiontransmembranetransport
C-C motif chemokine 15
54
C-C chemokine receptor type 1
24
8.5
63
0.19
CCL15CCR1Q16663P32246cell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitysignaltransductioncalciumiontransportcalcium-mediatedsignalingcelladhesioncellchemotaxiscellsurfacereceptorsignalingpathwaycytokine-mediatedsignalingpathwaydendriticcellchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerimmuneresponsenegativeregulationofbonemineralizationnegativeregulationofgeneexpressionpositiveregulationofcalciumiontransportpositiveregulationofcellmigrationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofmonocytechemotaxispositiveregulationofosteoclastdifferentiationresponsetowounding
Igh protein
308
Igh protein
308
8.4
52
0.23
Q99M22Q99M22Q99M22Q99M22
Guided entry of tail-anchored proteins factor 1
157
Guided entry of tail-anchored proteins factor CAMLG
275
8.5
55
0.21
GET1CAMLGO00258P49069proteininsertionintoERmembraneproteinstabilizationtail-anchoredmembraneproteininsertionintoERmembraneBcellhomeostasisdefenseresponseepidermalgrowthfactorreceptorsignalingpathwaynegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofproteinubiquitinationreceptorrecyclingsignaltransductionvesicle-mediatedtransport
Clathrin heavy chain
1573
Clathrin light chain
178
8.5
68
0.17
C0MHR2F1S398C0MHR2F1S398clathrincoatassemblyintracellularproteintransportmitoticcellcyclereceptor-mediatedendocytosisclathrin-dependentendocytosis
Insulin-like growth factor 1 receptor
703
Insulin-like growth factor 1 receptor
701
4.7
nan
nan
IGF1RIGF1RQ60751Q60751adrenalglanddevelopmentamyloid-betaclearanceanimalorganmorphogenesisaxonogenesisbraindevelopmentcellularresponsetoamyloid-betacellularresponsetoglucosestimuluscellularresponsetoinsulinstimuluscellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetotransforminggrowthfactorbetastimuluscerebellumdevelopmentdendriticspinemaintenanceepidermisdevelopmentestablishmentofcellpolarityestrouscycleexocrinepancreasdevelopmentglucosehomeostasisimmuneresponseinsulinreceptorsignalingpathwayinsulin-likegrowthfactorreceptorsignalingpathwaymalesexdeterminationmammaryglanddevelopmentMAPKcascademitoticnucleardivisionnegativeregulationofapoptoticprocessnegativeregulationofcholangiocyteapoptoticprocessnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofhepatocyteapoptoticprocessnegativeregulationofMAPKcascadenegativeregulationofmusclecellapoptoticprocessnegativeregulationofproteinkinaseBsignalingneuronprojectiondevelopmentpeptidyl-tyrosineautophosphorylationphosphatidylinositol-mediatedsignalingpositiveregulationofaxonregenerationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcold-inducedthermogenesispositiveregulationofcytokinesispositiveregulationofdevelopmentalgrowthpositiveregulationofDNAmetabolicprocesspositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastproliferationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsteroidhormonebiosyntheticprocesspositiveregulationoftranscriptionDNA-templatedprostateglandepitheliummorphogenesisproteinautophosphorylationproteinkinaseBsignalingproteinphosphorylationregulationofJNKcascaderesponsetoethanolresponsetoL-glutamatetranscytosistransmembranereceptorproteintyrosinekinasesignalingpathway
Calcium homeostasis modulator protein 2
179
Calcium homeostasis modulator protein 2
46
8.1
82
0.15
CAHM2CAHM2Q9HA72Q9HA72positiveregulationofapoptoticprocess
Protein tweety homolog 2
101
Protein tweety homolog 2
227
8.4
69
0.17
TTYH2TTYH2Q9BSA4Q9BSA4
Calcium homeostasis modulator protein 2
179
Calcium homeostasis modulator protein 2
130
8.0
79
0.16
CAHM2CAHM2Q9HA72Q9HA72positiveregulationofapoptoticprocess
GATOR complex protein NPRL2
286
GATOR complex protein NPRL3
411
7.5
74
0.18
NPRL2NPRL3Q8WTW4Q12980cellularresponsetoaminoacidstarvationnegativeregulationofkinaseactivitynegativeregulationofTORsignalingnegativeregulationofTORC1signalingpositiveregulationofautophagyaortamorphogenesiscardiacmuscletissuedevelopmentroofofmouthdevelopmentTORC1signalingventricularseptumdevelopment
Glutamate receptor ionotropic, NMDA 2B
321
Glutamate receptor ionotropic, NMDA 1
831
8.0
47
0.27
NMDE2NMDZ1Q00960P35439actionpotentialassociativelearningbehavioralfearresponsebehavioralresponsetopaincalciumiontransmembraneimportintocytosolcalciumiontransportcationtransmembranetransportcationtransportcellularresponsetoaminoacidstimuluscellularresponsetocorticosteronestimuluscellularresponsetocurcumincellularresponsetodsRNAcellularresponsetoforskolincellularresponsetogrowthfactorstimuluscellularresponsetolipidcellularresponsetomagnesiumstarvationcellularresponsetomanganeseioncellularresponsetoorganiccycliccompoundcerebralcortexdevelopmentchemicalsynaptictransmissiondetectionofmechanicalstimulusinvolvedinsensoryperceptionofpainexcitatorypostsynapticpotentialfearresponsehippocampusdevelopmentinuteroembryonicdevelopmentionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylong-termmemorylong-termsynapticpotentiationmemorymulticellularorganismalresponsetostressnegativeregulationofdendriticspinemaintenanceNMDAselectiveglutamatereceptorsignalingpathwaypositiveregulationofcelldeathpositiveregulationofcysteine-typeendopeptidaseactivitypositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofglutamatesecretionpositiveregulationofneurondeathpositiveregulationofsynaptictransmissionpositiveregulationofsynaptictransmissionglutamatergicproteinheterotetramerizationreceptorclusteringregulationofcationtransmembranetransportregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofneuronalsynapticplasticityregulationofpostsynapticcytosoliccalciumionconcentrationregulationofpostsynapticmembranepotentialregulationofproteinkinaseAsignalingregulationofsynapticplasticityresponsetoamineresponsetoamphetamineresponsetocalciumionresponsetocarbohydrateresponsetococaineresponsetocytokineresponsetoelectricalstimulusresponsetoethanolresponsetofungicideresponsetogrowthhormoneresponsetohypoxiaresponsetomagnesiumionresponsetomanganeseionresponsetomechanicalstimulusresponsetomethylmercuryresponsetoorganiccycliccompoundresponsetoorganonitrogencompoundresponsetootherorganismresponsetotoxicsubstancerhythmicprocesssensitizationsensoryorgandevelopmentstartleresponsesucklingbehavioradultlocomotorybehaviorcalciumionhomeostasiscellularcalciumionhomeostasisconditionedtasteaversionmalematingbehaviornegativeregulationofneuronapoptoticprocessneuromuscularprocessolfactorylearningponsmaturationpositiveregulationofapoptoticprocesspositiveregulationofcalciumiontransportintocytosolpositiveregulationofdendriticspinemaintenancepositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofSchwanncellmigrationpositiveregulationoftranscriptionbyRNApolymeraseIIprepulseinhibitionpropylenemetabolicprocessproteinlocalizationtopostsynapticmembraneprotein-containingcomplexassemblyregulationofaxonogenesisregulationofcellcommunicationregulationofdendritemorphogenesisregulationofmembranepotentialregulationofneuronapoptoticprocessregulationofrespiratorygaseousexchangeregulationofsynapseassemblyresponsetoglycineresponsetomorphinesensoryperceptionofpainsocialbehaviorsynaptictransmissionglutamatergicvisuallearning
Protein unc-79 homolog
541
Protein unc-80 homolog
2958
7.5
nan
nan
E5CYJ9UNC80E5CYJ9B8XCJ6cationhomeostasis
Calcium homeostasis modulator protein 2
46
Calcium homeostasis modulator protein 2
180
8.5
79
0.15
CAHM2CAHM2Q9HA72Q9HA72positiveregulationofapoptoticprocess
DNA-directed RNA polymerase I subunit RPA1
968
DNA-directed RNA polymerase I subunit RPA2
498
8.5
85
0.14
RPA1RPA2O95602Q9H9Y6negativeregulationofproteinlocalizationtonucleolusembryoimplantationneuralcrestformationnucleologenesisrRNAtranscription
Glycoprotein hormones alpha chain
31
Choriogonadotropin subunit beta 3
29
9.9
60
0.17
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
Pro-adrenomedullin
110
Calcitonin gene-related peptide type 1 receptor
299
8.6
58
0.2
ADMLCALRLP35318Q16602adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadrenomedullinreceptorsignalingpathwayagingamylinreceptorsignalingpathwayandrogenmetabolicprocessanimalorganregenerationantibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidebranchinginvolvedinlabyrinthinelayermorphogenesiscalciumionhomeostasiscAMP-mediatedsignalingcellpopulationproliferationdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdevelopmentalgrowthfemalepregnancyGprotein-coupledreceptorinternalizationheartdevelopmenthormonesecretioninflammatoryresponsenegativeregulationofcellpopulationproliferationnegativeregulationofvascularpermeabilitynegativeregulationofvasoconstrictionneuraltubeclosureneuronprojectionregenerationodontogenesisofdentin-containingtoothpositiveregulationofangiogenesispositiveregulationofapoptoticprocesspositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofheartratepositiveregulationofprogesteronebiosyntheticprocesspositiveregulationofvasculogenesisreceptorinternalizationregulationofsystemicarterialbloodpressureregulationoftheforceofheartcontractionregulationofurinevolumeresponsetocoldresponsetoglucocorticoidresponsetohypoxiaresponsetoinsulinresponsetolipopolysaccharideresponsetostarvationresponsetowoundingsignaltransductionspongiotrophoblastlayerdevelopmentvascularassociatedsmoothmusclecelldevelopmentvasculogenesisadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwayangiogenesiscalcitoningene-relatedpeptidereceptorsignalingpathwaycalciumiontransportcellsurfacereceptorsignalingpathwaycellularresponsetosucrosestimulusGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengernegativeregulationofinflammatoryresponsenegativeregulationofsmoothmusclecontractionpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteintransportvascularassociatedsmoothmusclecellproliferation
Neuronal acetylcholine receptor subunit beta-2
262
Neuronal acetylcholine receptor subunit beta-2
262
8.5
65
0.18
ACHB2ACHB2P17787P17787acetylcholinereceptorsignalingpathwayassociativelearningBcellactivationbehavioralresponsetonicotinecalciumiontransportcentralnervoussystemprojectionneuronaxonogenesischemicalsynaptictransmissioncognitioniontransmembranetransportiontransportlateralgeniculatenucleusdevelopmentlearninglocomotorybehaviormembranedepolarizationmemorynegativeregulationofactionpotentialnervoussystemprocessopticnervemorphogenesispositiveregulationofBcellproliferationpositiveregulationofdopaminesecretionregulationofcircadiansleep/wakecycleREMsleepregulationofdendritemorphogenesisregulationofdopaminemetabolicprocessregulationofdopaminesecretionregulationofmembranepotentialregulationofsynapseassemblyregulationofsynaptictransmissiondopaminergicresponsetoacetylcholineresponsetococaineresponsetoethanolresponsetohypoxiaresponsetonicotinesensoryperceptionofpainsensoryperceptionofsoundsignaltransductionsmoothmusclecontractionsocialbehaviorsynaptictransmissioninvolvedinmicturitionsynaptictransmissioncholinergicvestibulocochlearnervedevelopmentvisuallearningvisualperception
GATOR complex protein NPRL2
348
GATOR complex protein NPRL3
343
4.5
53
0.42
NPRL2NPRL3Q8WTW4Q12980cellularresponsetoaminoacidstarvationnegativeregulationofkinaseactivitynegativeregulationofTORsignalingnegativeregulationofTORC1signalingpositiveregulationofautophagyaortamorphogenesiscardiacmuscletissuedevelopmentroofofmouthdevelopmentTORC1signalingventricularseptumdevelopment
COP9 signalosome complex subunit 6
264
COP9 signalosome complex subunit 7b
178
7.8
57
0.23
CSN6CSN7BQ7L5N1Q9H9Q2proteindeneddylationproteinneddylationregulationofproteinneddylationCOP9signalosomeassembly
Proteasome subunit beta type-7
247
Proteasome subunit beta type-3
150
9.2
70
0.16
PSB7PSB3Q99436P49720proteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocess
General transcription factor IIH subunit 3
268
General transcription factor IIH subunit 2
247
8.4
81
0.15
TF2H3TF2H2Q13889Q13888DNArepairnucleotide-excisionrepairphosphorylationofRNApolymeraseIIC-terminaldomaintranscriptionbyRNApolymeraseIIGprotein-coupledreceptorinternalizationpositiveregulationofDNAhelicaseactivityregulationoftranscriptionbyRNApolymeraseIIresponsetoUVtranscriptioninitiationfromRNApolymeraseIIpromoter
Immunoglobulin J chain
123
Immunoglobulin heavy constant mu
452
7.9
64
0.2
IGJIGHMP01591P01871adaptiveimmuneresponseantibacterialhumoralresponseglomerularfiltrationhumoralimmuneresponseimmuneresponseinnateimmuneresponsepositiveregulationofrespiratoryburstprotein-containingcomplexassemblyretinahomeostasisBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumphagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Glutamate receptor ionotropic, NMDA 2B
946
Glutamate receptor ionotropic, NMDA 2B
946
4.8
56
0.38
NMDE2NMDE2Q00960Q00960actionpotentialassociativelearningbehavioralfearresponsebehavioralresponsetopaincalciumiontransmembraneimportintocytosolcalciumiontransportcationtransmembranetransportcationtransportcellularresponsetoaminoacidstimuluscellularresponsetocorticosteronestimuluscellularresponsetocurcumincellularresponsetodsRNAcellularresponsetoforskolincellularresponsetogrowthfactorstimuluscellularresponsetolipidcellularresponsetomagnesiumstarvationcellularresponsetomanganeseioncellularresponsetoorganiccycliccompoundcerebralcortexdevelopmentchemicalsynaptictransmissiondetectionofmechanicalstimulusinvolvedinsensoryperceptionofpainexcitatorypostsynapticpotentialfearresponsehippocampusdevelopmentinuteroembryonicdevelopmentionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylong-termmemorylong-termsynapticpotentiationmemorymulticellularorganismalresponsetostressnegativeregulationofdendriticspinemaintenanceNMDAselectiveglutamatereceptorsignalingpathwaypositiveregulationofcelldeathpositiveregulationofcysteine-typeendopeptidaseactivitypositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofglutamatesecretionpositiveregulationofneurondeathpositiveregulationofsynaptictransmissionpositiveregulationofsynaptictransmissionglutamatergicproteinheterotetramerizationreceptorclusteringregulationofcationtransmembranetransportregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofneuronalsynapticplasticityregulationofpostsynapticcytosoliccalciumionconcentrationregulationofpostsynapticmembranepotentialregulationofproteinkinaseAsignalingregulationofsynapticplasticityresponsetoamineresponsetoamphetamineresponsetocalciumionresponsetocarbohydrateresponsetococaineresponsetocytokineresponsetoelectricalstimulusresponsetoethanolresponsetofungicideresponsetogrowthhormoneresponsetohypoxiaresponsetomagnesiumionresponsetomanganeseionresponsetomechanicalstimulusresponsetomethylmercuryresponsetoorganiccycliccompoundresponsetoorganonitrogencompoundresponsetootherorganismresponsetotoxicsubstancerhythmicprocesssensitizationsensoryorgandevelopmentstartleresponsesucklingbehavior
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
180
8.5
84
0.14
NDUV1NDUV2P25708P04394mitochondrialelectrontransportNADHtoubiquinonecardiacmuscletissuedevelopmentnervoussystemdevelopment
Interleukin-25
115
Interleukin-25
170
8.5
83
0.14
IL25IL25Q9H293Q9H293eosinophildifferentiationinflammatoryresponsetoantigenicstimuluspositiveregulationoftranscriptionbyRNApolymeraseIIresponsetofungusresponsetonematode
DNA-directed RNA polymerase III subunit RPC1
19
DNA-directed RNA polymerase III subunit RPC2
1110
8.5
69
0.17
RPC1RPC2O14802Q9NW08defenseresponsetovirusinnateimmuneresponsepositiveregulationofinterferon-betaproductiontranscriptionDNA-templatedpositiveregulationofinnateimmuneresponse
RNA polymerase II elongation factor ELL2
19
ELL-associated factor 1
46
8.6
nan
nan
ELL2EAF1O00472Q96JC9positiveregulationoftranscriptionelongationfromRNApolymeraseIIpromotersnRNAtranscriptionbyRNApolymeraseIItranscriptionelongationfromRNApolymeraseIIpromoterpositiveregulationoftranscriptionDNA-templatedregulationoftranscriptionelongationfromRNApolymeraseIIpromoter
Myosin-4
817
Myosin regulatory light chain 11
128
9.3
52
0.21
MYH4MYL11Q5SX39P97457musclecontractionresponsetoactivityimmuneresponseskeletalmuscletissuedevelopment
Lutropin-choriogonadotropic hormone receptor
131
Choriogonadotropin subunit beta 3
120
8.3
93
0.13
LSHRCGB3P22888P0DN86activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayarachidonicacidsecretioncellularresponsetogonadotropinstimuluscellularresponsetoluteinizinghormonestimuluscentralnervoussystemdevelopmentcognitiondevelopmentofsecondarymalesexualcharacteristicsGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerhormone-mediatedsignalingpathwayluteinizinghormonesignalingpathwaymalegenitaliadevelopmentmalegonaddevelopmentovarianfollicledevelopmentovulationcycleprocessphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcalciumiontransportintocytosolpositiveregulationofcalcium-mediatedsignalingpositiveregulationofhormonebiosyntheticprocesspositiveregulationofinositoltrisphosphatebiosyntheticprocesspositiveregulationofreleaseofsequesteredcalciumionintocytosolproteintargetingtolysosomeregulationofsteroidhormonebiosyntheticprocessresponsetoxenobioticstimulusseminiferoustubuledevelopmentspermatogenesisuterusdevelopmentapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
194
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
155
8.8
100
0.11
NDUS7NDUS8Q9DC70Q8K3J1aerobicrespirationelectrontransportcoupledprotontransportmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyprotonmotiveforce-drivenmitochondrialATPsynthesisresponsetooxidativestress
Protein unc-79 homolog
594
Protein unc-80 homolog
2890
7.6
nan
nan
UNC79UNC80Q9P2D8Q8N2C7cationhomeostasis
Endophilin-B1
241
Endophilin-B1
241
7.7
70
0.19
SHLB1SHLB1Q9Y371Q9Y371apoptoticprocessautophagiccelldeathautophagycellularresponsetoaminoacidstarvationcellularresponsetoglucosestarvationmembranefissionmembraneorganizationpositiveregulationofautophagosomeassemblypositiveregulationofautophagypositiveregulationofmembranetubulationpositiveregulationofproteintargetingtomitochondrionpositiveregulationofprotein-containingcomplexassemblyproteinlocalizationtovacuolarmembranereceptorcatabolicprocessregulationofcytokinesisregulationofmacroautophagyregulationofproteinstability
Glutamate receptor 2
549
Protein cornichon homolog 3
9
9.4
82
0.13
GRIA2CNIH3P19491Q6ZWS4chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumionlocalizationwithinmembraneneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneregulationofAMPAreceptoractivityregulationofmembranepotentialsynaptictransmissionglutamatergicvesicle-mediatedtransport
Endophilin-B1
121
Endophilin-B1
226
9.3
73
0.15
SHLB1SHLB1Q9Y371Q9Y371apoptoticprocessautophagiccelldeathautophagycellularresponsetoaminoacidstarvationcellularresponsetoglucosestarvationmembranefissionmembraneorganizationpositiveregulationofautophagosomeassemblypositiveregulationofautophagypositiveregulationofmembranetubulationpositiveregulationofproteintargetingtomitochondrionpositiveregulationofprotein-containingcomplexassemblyproteinlocalizationtovacuolarmembranereceptorcatabolicprocessregulationofcytokinesisregulationofmacroautophagyregulationofproteinstability
von Willebrand factor
1099
von Willebrand factor
1097
7.7
82
0.16
VWFVWFP04275P04275bloodcoagulationcelladhesioncell-substrateadhesionhemostasisplateletactivationpositiveregulationofintracellularsignaltransductionresponsetowounding
DNA-directed RNA polymerase II subunit RPB3
236
DNA-directed RNA polymerases I, II, and III subunit RPABC5
10
7.7
98
0.13
I3LCH3A0A4X1VYD0I3LCH3A0A4X1VYD0transcriptionbyRNApolymeraseIItranscriptionDNA-templated
Ion channel TACAN
173
Ion channel TACAN
173
7.7
62
0.21
TACANTACANQ9BXJ8Q9BXJ8detectionofmechanicalstimulusinvolvedinsensoryperceptionofpainfatcelldifferentiationiontransmembranetransportproteinheterooligomerizationproteinhomooligomerization
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
223
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
9.2
90
0.12
NDUV2NDUV1Q9D6J6Q91YT0aerobicrespirationcardiacmuscletissuedevelopmentmitochondrialelectrontransportNADHtoubiquinonenervoussystemdevelopmentprotonmotiveforce-drivenmitochondrialATPsynthesismitochondrialATPsynthesiscoupledelectrontransport
Rapamycin-insensitive companion of mTOR
187
Target of rapamycin complex 2 subunit MAPKAP1
27
9.2
78
0.14
RICTRSIN1Q6R327Q9BPZ7actincytoskeletonreorganizationcellularresponsetonutrientlevelscytoskeletonorganizationembryodevelopmentendinginbirthoregghatchingnegativeregulationofapoptoticprocesspeptidyl-serinephosphorylationphosphorylationpositiveregulationofactinfilamentpolymerizationpositiveregulationofcellgrowthpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofTORsignalingregulationofactincytoskeletonorganizationregulationofestablishmentofcellpolarityregulationofgeneexpressionregulationofGTPaseactivityregulationofinflammatoryresponseregulationofpeptidyl-serinephosphorylationregulationofproteinkinaseBsignalingTORC2signalingnegativeregulationofRasproteinsignaltransductionpositiveregulationofpeptidyl-serinephosphorylationregulationofcellularresponsetooxidativestresssubstantianigradevelopment
39S ribosomal protein L20, mitochondrial
93
39S ribosomal protein L42, mitochondrial
60
9.4
82
0.13
RM20RM42Q9BYC9Q9Y6G3mitochondrialtranslationribosomallargesubunitassemblytranslation
Isoform 5 of Inosine-5'-monophosphate dehydrogenase 1
414
Isoform 5 of Inosine-5'-monophosphate dehydrogenase 1
543
9.4
95
0.11
IMDH1IMDH1P20839-5P20839-5
Prefoldin subunit 3
113
Prefoldin subunit 5
49
9.4
86
0.12
PFD3PFD5P61758Q99471microtubule-basedprocessnegativeregulationofamyloidfibrilformationproteinfoldingproteinstabilizationtubulincomplexassemblynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationoftranscriptionDNA-templatedregulationoftranscriptionDNA-templatedretinadevelopmentincamera-typeeye
N-formyl peptide receptor 2
126
Guanine nucleotide-binding protein G(i) subunit alpha-2
352
7.7
74
0.18
FPR2GNAI2P25090P04899adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayastrocyteactivationcalcium-mediatedsignalingcelladhesioncellsurfacereceptorsignalingpathwaycellularresponsetoamyloid-betachemotaxiscomplementreceptormediatedsignalingpathwaydefenseresponsetobacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponse-regulatingcellsurfacereceptorsignalingpathwayinflammatoryresponsemicroglialcellactivationnegativeregulationofinflammatoryresponsephospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositivechemotaxispositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofinnateimmuneresponsepositiveregulationofmonocytechemotaxispositiveregulationofphagocytosispositiveregulationofproteinphosphorylationpositiveregulationofsuperoxideaniongenerationreceptor-mediatedendocytosisadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellpopulationproliferationGprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledadenosinereceptorsignalingpathwaygamma-aminobutyricacidsignalingpathwaynegativeregulationofadenylatecyclaseactivitynegativeregulationofadenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocessnegativeregulationofapoptoticsignalingpathwaynegativeregulationofcalciumion-dependentexocytosisnegativeregulationofproteintyrosinephosphataseactivitynegativeregulationofsynaptictransmissionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofNAD(P)Hoxidaseactivitypositiveregulationofneuralprecursorcellproliferationpositiveregulationofrenalsodiumexcretionpositiveregulationofurinevolumepositiveregulationofvascularassociatedsmoothmusclecellproliferationregulationofcalciumiontransportresponsetonutrientsignaltransduction
DNA-directed RNA polymerase I subunit RPA1
968
DNA-directed RNA polymerase I subunit RPA2
689
9.4
90
0.12
RPA1RPA2O95602Q9H9Y6negativeregulationofproteinlocalizationtonucleolusembryoimplantationneuralcrestformationnucleologenesisrRNAtranscription
Excitatory amino acid transporter 2
184
Excitatory amino acid transporter 2
184
9.4
82
0.13
EAA2EAA2P43004P43004adultbehaviorcellularresponsetococainecellularresponsetoextracellularstimuluschemicalsynaptictransmissionD-aspartateimportacrossplasmamembraneglutathionebiosyntheticprocessiontransportL-aspartateimportacrossplasmamembraneL-aspartatetransmembranetransportL-glutamateimportacrossplasmamembraneL-glutamatetransmembranetransportmulticellularorganismagingmulticellularorganismgrowthneurotransmitterreuptakeneurotransmittertransportpositiveregulationofglucoseimportproteinhomotrimerizationresponsetoaminoacidresponsetowoundingresponsetoxenobioticstimulustelencephalondevelopmenttransepithelialtransporttransportacrossblood-brainbarriervisualbehavior
DNA-directed RNA polymerase III subunit RPC1
565
DNA-directed RNA polymerases I and III subunit RPAC2
68
7.7
91
0.14
RPC1RPAC2O14802P0DPB6defenseresponsetovirusinnateimmuneresponsepositiveregulationofinterferon-betaproductiontranscriptionDNA-templated
DDB1- and CUL4-associated factor 1
784
DDB1- and CUL4-associated factor 1
784
7.7
52
0.25
DCAF1DCAF1Q9Y4B6Q9Y4B6BcelldifferentiationcellcompetitioninamulticellularorganismchromatinorganizationhistoneH2A-T120phosphorylationnegativeregulationoftranscriptionbyRNApolymeraseIIpost-translationalproteinmodificationproteinubiquitinationV(D)Jrecombination
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
382
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
75
9.4
90
0.12
W5PUX0W5QB34W5PUX0W5QB34mitochondrialATPsynthesiscoupledelectrontransportapoptoticmitochondrialchangesATPmetabolicprocessmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyreactiveoxygenspeciesmetabolicprocessregulationofmitochondrialmembranepotential
Lutropin-choriogonadotropic hormone receptor
156
Choriogonadotropin subunit beta 3
113
9.4
78
0.14
LSHRCGB3P22888P0DN86activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayarachidonicacidsecretioncellularresponsetogonadotropinstimuluscellularresponsetoluteinizinghormonestimuluscentralnervoussystemdevelopmentcognitiondevelopmentofsecondarymalesexualcharacteristicsGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerhormone-mediatedsignalingpathwayluteinizinghormonesignalingpathwaymalegenitaliadevelopmentmalegonaddevelopmentovarianfollicledevelopmentovulationcycleprocessphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcalciumiontransportintocytosolpositiveregulationofcalcium-mediatedsignalingpositiveregulationofhormonebiosyntheticprocesspositiveregulationofinositoltrisphosphatebiosyntheticprocesspositiveregulationofreleaseofsequesteredcalciumionintocytosolproteintargetingtolysosomeregulationofsteroidhormonebiosyntheticprocessresponsetoxenobioticstimulusseminiferoustubuledevelopmentspermatogenesisuterusdevelopmentapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
DNA-directed RNA polymerase II subunit RPB1
1430
DNA-directed RNA polymerase subunit beta
1155
9.4
82
0.13
RPB1A0A0B8RVL1P11414A0A0B8RVL1positiveregulationofRNAsplicingtranscriptionbyRNApolymeraseIItranscriptionDNA-templated
COP9 signalosome complex subunit 3
383
COP9 signalosome complex subunit 6
299
9.4
89
0.12
CSN3CSN6Q9UNS2Q7L5N1inuteroembryonicdevelopmentproteindeneddylationproteinneddylationregulationofDNAdamageresponsesignaltransductionbyp53classmediatorresultingintranscriptionofp21classmediatorregulationofproteinneddylationresponsetolightstimulussignaltransductionubiquitin-dependentproteincatabolicprocess
Interleukin-25
170
Interleukin-25
170
7.8
91
0.14
IL25IL25Q9H293Q9H293eosinophildifferentiationinflammatoryresponsetoantigenicstimuluspositiveregulationoftranscriptionbyRNApolymeraseIIresponsetofungusresponsetonematode
Glutamate receptor ionotropic, delta-1
80
Glutamate receptor ionotropic, delta-1
80
7.8
66
0.2
GRID1GRID1Q62640Q62640modulationofchemicalsynaptictransmissionsocialbehaviorsynaptictransmissionglutamatergic
Broad substrate specificity ATP-binding cassette transporter ABCG2
603
Broad substrate specificity ATP-binding cassette transporter ABCG2
608
9.4
74
0.14
ABCG2ABCG2Q9UNQ0Q9UNQ0biotintransportcellulardetoxificationexportacrossplasmamembranelipidtransportorganicaniontransportrenaluratesaltexcretionriboflavintransporttransepithelialtransporttransmembranetransporttransportacrossblood-brainbarrieruratemetabolicprocessxenobiotictransportacrossblood-brainbarrier
Guided entry of tail-anchored proteins factor 1
162
Guided entry of tail-anchored proteins factor CAMLG
275
7.7
64
0.2
GET1CAMLGO00258P49069proteininsertionintoERmembraneproteinstabilizationtail-anchoredmembraneproteininsertionintoERmembraneBcellhomeostasisdefenseresponseepidermalgrowthfactorreceptorsignalingpathwaynegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofproteinubiquitinationreceptorrecyclingsignaltransductionvesicle-mediatedtransport
Angiotensin-converting enzyme 2
133
Angiotensin-converting enzyme 2
133
7.7
48
0.27
ACE2ACE2Q9BYF1Q9BYF1angiotensinmaturationangiotensin-mediateddrinkingbehaviorbloodvesseldiametermaintenancematernalprocessinvolvedinfemalepregnancymembranefusionnegativeregulationofERK1andERK2cascadenegativeregulationofsignalingreceptoractivitynegativeregulationofsmoothmusclecellproliferationpositiveregulationofaminoacidtransportpositiveregulationofcardiacmusclecontractionpositiveregulationofgapjunctionassemblypositiveregulationofL-prolineimportacrossplasmamembranepositiveregulationofreactiveoxygenspeciesmetabolicprocessreceptor-mediatedendocytosisofvirusbyhostcellreceptor-mediatedvirionattachmenttohostcellregulationofcardiacconductionregulationofcellpopulationproliferationregulationofcytokineproductionregulationofinflammatoryresponseregulationofsystemicarterialbloodpressurebyrenin-angiotensinregulationoftransmembranetransporteractivityregulationofvasoconstrictiontryptophantransportviralentryintohostcellvirallifecycle
Glutamate receptor 2
330
Glutamate receptor 1
75
7.7
75
0.17
GRIA2GRIA1P19491P19490chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumioncellularresponsetoaminestimuluscellularresponsetoaminoacidstimuluscellularresponsetoammoniumioncellularresponsetodsRNAcellularresponsetogrowthfactorstimuluscellularresponsetoorganiccycliccompoundcellularresponsetopeptidehormonestimuluslong-termmemorylong-termsynapticdepressionmodulationofchemicalsynaptictransmissionneuronalactionpotentialpositiveregulationofmembranepotentialregulationofpostsynapticmembranepotentialregulationofsynapticplasticityresponsetoarsenic-containingsubstanceresponsetococaineresponsetoelectricalstimulusresponsetoestradiolresponsetoorganiccycliccompoundresponsetopeptidehormoneresponsetotoxicsubstanceresponsetoxenobioticstimulusspinalcorddevelopmentsynaptictransmissionglutamatergic
DNA-directed RNA polymerase II subunit RPB3
236
DNA-directed RNA polymerases I, II, and III subunit RPABC5
10
9.4
92
0.12
RPB3RPAB5Q3T0Q3Q32P78transcriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseItRNAtranscriptionbyRNApolymeraseIII
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
176
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
7.7
95
0.14
NDUV2NDUV1P04394P25708cardiacmuscletissuedevelopmentmitochondrialelectrontransportNADHtoubiquinonenervoussystemdevelopment
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
140
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
9.4
93
0.11
NDUV2NDUV1P04394P25708cardiacmuscletissuedevelopmentmitochondrialelectrontransportNADHtoubiquinonenervoussystemdevelopment
von Willebrand factor
1101
von Willebrand factor
1097
7.7
77
0.17
VWFVWFP04275P04275bloodcoagulationcelladhesioncell-substrateadhesionhemostasisplateletactivationpositiveregulationofintracellularsignaltransductionresponsetowounding
Rhodopsin
140
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
9.2
59
0.18
OPSDGNAI1P08100P63096absorptionofvisiblelightcellularresponsetolightstimulusdetectionoftemperaturestimulusinvolvedinthermoceptionGprotein-coupledreceptorsignalingpathwayphotoreceptorcellmaintenancephototransductionphototransductionvisiblelightproteinphosphorylationretinadevelopmentincamera-typeeyerhodopsinmediatedsignalingpathwaythermotaxisvisualperceptionadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinpositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormone
Dynactin subunit 6
129
Dynactin subunit 5
149
7.5
74
0.18
D0G6S1A0A286ZK88D0G6S1A0A286ZK88mitoticspindleorganizationaortadevelopmentcoronaryvasculaturedevelopmentventricularseptumdevelopment
Protocadherin-15
1392
LHFPL tetraspan subfamily member 5 protein
35
7.5
69
0.19
PCD15LHPL5Q99PJ1Q4KL25actinfilamentorganizationadultwalkingbehaviorauditoryreceptorcellstereociliumorganizationcelladhesiondetectionofmechanicalstimulusinvolvedinequilibrioceptiondetectionofmechanicalstimulusinvolvedinsensoryperceptionofsoundequilibrioceptionhomophiliccelladhesionviaplasmamembraneadhesionmoleculesinnerearauditoryreceptorcelldifferentiationinnereardevelopmentinnerearreceptorcellstereociliumorganizationlocomotorybehaviormorphogenesisofanepitheliummulticellularorganismgrowthnon-motileciliumassemblyphotoreceptorcellmaintenancerightingreflexsensoryperceptionoflightstimulussensoryperceptionofsoundstartleresponsevisualperceptiondetectionofmechanicalstimulusinvolvedinsensoryperceptioniontransport
Hepcidin
82
Solute carrier family 40 member 1
326
7.4
76
0.18
HEPCS40A1P81172Q9NP59acute-phaseresponseagingantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularironionhomeostasiscellularresponsetobileacidcellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactorcellularresponsetoX-raydefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumestablishmentoflocalizationincellimmuneresponseironiontransmembranetransportkillingofcellsofanotherorganismliverregenerationmacrophageactivationmulticellularorganismalironionhomeostasismyeloidcellhomeostasisnegativeregulationofboneresorptionnegativeregulationofinflammatoryresponsenegativeregulationofintestinalabsorptionnegativeregulationofiontransmembranetransporteractivitynegativeregulationofironexportacrossplasmamembranenegativeregulationofironiontransmembranetransportnegativeregulationofironiontransmembranetransporteractivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofmacrophageactivationpositiveregulationofproteincatabolicprocesspositiveregulationofproteinpolyubiquitinationpositiveregulationofreceptorcatabolicprocesspositiveregulationofreceptorinternalizationpositiveregulationoftranscriptionbyRNApolymeraseIIproteincatabolicprocessreceptorsignalingpathwayviaJAK-STATresponsetoerythropoietinresponsetoethanolresponsetoironionresponsetoironionstarvationresponsetovitaminAresponsetozinciontranscriptionbyRNApolymeraseIIapoptoticprocessendotheliumdevelopmentironionexportacrossplasmamembraneironionhomeostasislymphocytehomeostasisnegativeregulationofapoptoticprocessregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoironspleentrabeculaformation
Glutamate receptor 2
330
Glutamate receptor 1
323
7.4
76
0.18
GRIA2GRIA1P19491P19490chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumioncellularresponsetoaminestimuluscellularresponsetoaminoacidstimuluscellularresponsetoammoniumioncellularresponsetodsRNAcellularresponsetogrowthfactorstimuluscellularresponsetoorganiccycliccompoundcellularresponsetopeptidehormonestimuluslong-termmemorylong-termsynapticdepressionmodulationofchemicalsynaptictransmissionneuronalactionpotentialpositiveregulationofmembranepotentialregulationofpostsynapticmembranepotentialregulationofsynapticplasticityresponsetoarsenic-containingsubstanceresponsetococaineresponsetoelectricalstimulusresponsetoestradiolresponsetoorganiccycliccompoundresponsetopeptidehormoneresponsetotoxicsubstanceresponsetoxenobioticstimulusspinalcorddevelopmentsynaptictransmissionglutamatergic
Calcium/calmodulin-dependent protein kinase type II subunit alpha
428
Calcium/calmodulin-dependent protein kinase type II subunit alpha
428
7.4
104
0.13
KCC2AKCC2AP11275P11275angiotensin-activatedsignalingpathwaycalciumiontransportcalmodulindependentkinasesignalingpathwaydendritemorphogenesisdendriticspinedevelopmentG1/StransitionofmitoticcellcycleionotropicglutamatereceptorsignalingpathwaynegativeregulationofhydrolaseactivityNMDAselectiveglutamatereceptorsignalingpathwaypeptidyl-serinephosphorylationpeptidyl-threonineautophosphorylationpositiveregulationofcalciumiontransportpositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofNF-kappaBtranscriptionfactoractivitypostsynapticneurotransmitterreceptordiffusiontrappingproteinautophosphorylationproteinphosphorylationregulationofendocannabinoidsignalingpathwayregulationofmitochondrialmembranepermeabilityinvolvedinapoptoticprocessregulationofneuronmigrationregulationofneuronalsynapticplasticityregulationofneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneregulationofneurotransmittersecretionregulationofproteinlocalizationtoplasmamembraneregulationofsynapticvesicledockingresponsetoischemia
Pannexin-1
426
Pannexin-1
426
7.4
nan
nan
PANX1PANX1Q96RD7Q96RD7calciumiontransportcationtransportcell-cellsignalingoogenesispositiveregulationofinterleukin-1alphaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofmacrophagecytokineproductionresponsetoATPresponsetoischemia
Ribosome maturation protein SBDS
210
Elongation factor-like GTPase 1
934
7.4
73
0.19
SBDSEFL1Q9Y3A5Q7Z2Z2bonemarrowdevelopmentbonemineralizationhematopoieticprogenitorcelldifferentiationinnercellmasscellproliferationleukocytechemotaxismatureribosomeassemblymitoticspindleorganizationrRNAprocessingGTPmetabolicprocess
THO complex subunit 1
156
THO complex subunit 2
202
7.5
73
0.18
THOC1THOC2Q96FV9Q8NI27apoptoticprocessmRNAexportfromnucleusmRNAprocessingnegativeregulationofDNAdamagecheckpointnegativeregulationofisotypeswitchingtoIgAisotypespositiveregulationofDNA-templatedtranscriptionelongationregulationofDNArecombinationregulationofDNA-templatedtranscriptionelongationreplicationforkprocessingRNAprocessingRNAsplicingsignaltransductionviralmRNAexportfromhostcellnucleusblastocystdevelopmentcellmorphogenesisgenerationofneuronsnegativeregulationofneuronprojectiondevelopmentneurondevelopmentpoly(A)+mRNAexportfromnucleusregulationofgeneexpressionregulationofmRNAexportfromnucleusstemcelldivision
Protein arginine N-methyltransferase 5
196
Protein arginine N-methyltransferase 5
622
9.2
70
0.16
ANM5ANM5O14744O14744chromatinorganizationcircadianregulationofgeneexpressionDNA-templatedtranscriptionterminationendothelialcellactivationGolgiribbonformationhistoneargininemethylationhistoneH4-R3methylationliverregenerationnegativeregulationofcelldifferentiationpeptidyl-argininemethylationpeptidyl-arginineN-methylationpositiveregulationofadenylatecyclase-inhibitingdopaminereceptorsignalingpathwaypositiveregulationofmRNAsplicingviaspliceosomepositiveregulationofoligodendrocytedifferentiationregulationofDNAmethylationregulationofERK1andERK2cascaderegulationofmitoticnucleardivisionregulationofsignaltransductionbyp53classmediatorregulationoftranscriptionDNA-templatedspliceosomalsnRNPassembly
General transcription factor IIH subunit 3
285
General transcription factor IIH subunit 2
247
7.5
67
0.2
TF2H3TF2H2Q13889Q13888DNArepairnucleotide-excisionrepairphosphorylationofRNApolymeraseIIC-terminaldomaintranscriptionbyRNApolymeraseIIGprotein-coupledreceptorinternalizationpositiveregulationofDNAhelicaseactivityregulationoftranscriptionbyRNApolymeraseIIresponsetoUVtranscriptioninitiationfromRNApolymeraseIIpromoter
Sodium channel protein type 9 subunit alpha
897
Sodium channel subunit beta-2
55
9.2
57
0.19
SCN9ASCN2BQ15858O60939behavioralresponsetoformalininducedpaininflammatoryresponsemembranedepolarizationduringactionpotentialnegativeregulationofactionpotentialneuronalactionpotentialpost-embryonicdevelopmentregulationofiontransmembranetransportresponsetocoldresponsetoheatresponsetotoxicsubstancesensoryperceptionofpainsodiumiontransmembranetransportsodiumiontransportcardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractionchemicalsynaptictransmissiongeneexpressionmembranedepolarizationduringcardiacmusclecellactionpotentialnervoussystemdevelopmentregulationofatrialcardiacmusclecellmembranedepolarizationregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityresponsetopyrethroid
Uncharacterized protein
79
Dynactin subunit 5
149
9.2
68
0.16
A0A4X1TB62A0A286ZK88A0A4X1TB62A0A286ZK88aortadevelopmentcoronaryvasculaturedevelopmentventricularseptumdevelopment
Splicing factor 3B subunit 1
677
PHD finger-like domain-containing protein 5A
49
7.4
76
0.18
SF3B1PHF5AO75533Q7RTV0chromatinremodelingmRNAsplicingviaspliceosomepositiveregulationofhistoneacetylationpositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIRNAsplicingRNAsplicingviatransesterificationreactionsspliceosomalcomplexassemblyU2-typeprespliceosomeassemblypositiveregulationoftranscriptionDNA-templatedstemcelldifferentiation
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
727
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
112
9.2
nan
nan
NDUS1NDUS6P15690P23934apoptoticmitochondrialchangesATPmetabolicprocesscellularrespirationmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyreactiveoxygenspeciesmetabolicprocessregulationofmitochondrialmembranepotential
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
222
7.4
95
0.14
W5PUX0W5NRY1W5PUX0W5NRY1mitochondrialATPsynthesiscoupledelectrontransport
DNA-directed RNA polymerase I subunit RPA2
93
DNA-directed RNA polymerases I, II, and III subunit RPABC4
39
7.4
52
0.26
RPA2RPAB4Q9H9Y6P53803embryoimplantationneuralcrestformationnucleologenesisrRNAtranscriptionregulationoftranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseIII
Insulin receptor
710
Insulin receptor
712
7.5
49
0.27
INSRINSRP06213P06213activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearancecarbohydratemetabolicprocesscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaylearningmalegonaddevelopmentmalesexdeterminationmemoryneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationoftranscriptionDNA-templatedtransmembranereceptorproteintyrosinekinasesignalingpathwaytransportacrossblood-brainbarrierviralentryintohostcell
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
180
7.4
92
0.15
NDUV1NDUV2P49821P19404aerobicrespirationmitochondrialATPsynthesiscoupledelectrontransportmitochondrialelectrontransportNADHtoubiquinoneprotonmotiveforce-drivenmitochondrialATPsynthesiscardiacmuscletissuedevelopmentnervoussystemdevelopment
Glutamate receptor 1
323
Glutamate receptor
330
9.2
72
0.15
GRIA1G5E8H1P23818G5E8H1cellularresponsetoammoniumionchemicalsynaptictransmissionlong-termmemorylong-termsynapticdepressionmodulationofchemicalsynaptictransmissionneuronalactionpotentialpositiveregulationofmembranepotentialpositiveregulationofsynaptictransmissionreceptorinternalizationregulationofpostsynapticmembranepotentialregulationofreceptorrecyclingregulationofsynapticplasticityresponsetotoxicsubstance
Tapasin
115
Protein disulfide-isomerase A3
60
7.4
64
0.21
TPSNPDIA3O15533P30101antigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIimmuneresponseMHCclassIproteincomplexassemblyMHCclassIbproteincomplexassemblypeptideantigenassemblywithMHCclassIproteincomplexpeptideantigenstabilizationprotein-containingcomplexassemblyregulationofgeneexpressionregulationofimmuneresponseregulationofproteincomplexstabilityretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulumcellularresponsetointerleukin-7extrinsicapoptoticsignalingpathwaypositiveregulationofextrinsicapoptoticsignalingpathwayproteinfoldingproteinfoldinginendoplasmicreticulumresponsetoendoplasmicreticulumstress
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
Muscarinic acetylcholine receptor M4
133
7.5
69
0.19
GNAI1ACM4P63096P08173adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormoneadenylatecyclase-inhibitingGprotein-coupledacetylcholinereceptorsignalingpathwaycellsurfacereceptorsignalingpathwaychemicalsynaptictransmissionGprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerregulationoflocomotionsignaltransduction
Protein inturned
838
Protein fuzzy homolog
365
7.5
83
0.16
INTUE9QL29Q059U7E9QL29celldivisionciliumassemblyembryonicdigitmorphogenesisestablishmentofplanarpolarityhairfolliclemorphogenesisintraciliarytransportkeratinocytedifferentiationlimbdevelopmentmotileciliumassemblynegativeregulationofcelldivisionnegativeregulationofkeratinocyteproliferationnervoussystemdevelopmentneuraltubedevelopmentnon-motileciliumassemblypositiveregulationofsmoothenedsignalingpathwayproteinlocalizationtoorganelleregulationofciliumassemblyregulationofossificationregulationofsmoothenedsignalingpathwayroofofmouthdevelopmentsmoothenedsignalingpathwayspinalcorddorsal/ventralpatterningtonguemorphogenesisvesicle-mediatedtransportnegativeregulationofcellmigrationneuraltubeclosurepositiveregulationofciliumassembly
Glutamate receptor
99
Glutamate receptor
350
9.2
66
0.16
G3V9I2G3V9I2G3V9I2G3V9I2
Glutamate receptor 1
323
Glutamate receptor
78
9.4
70
0.15
GRIA1G5E8H1P23818G5E8H1cellularresponsetoammoniumionchemicalsynaptictransmissionlong-termmemorylong-termsynapticdepressionmodulationofchemicalsynaptictransmissionneuronalactionpotentialpositiveregulationofmembranepotentialpositiveregulationofsynaptictransmissionreceptorinternalizationregulationofpostsynapticmembranepotentialregulationofreceptorrecyclingregulationofsynapticplasticityresponsetotoxicsubstance
Dynactin subunit 6
128
Dynactin subunit 5
114
9.4
83
0.13
D0G6S1A0A286ZK88D0G6S1A0A286ZK88mitoticspindleorganizationaortadevelopmentcoronaryvasculaturedevelopmentventricularseptumdevelopment
C-C motif chemokine 15
54
C-C chemokine receptor type 1
273
9.4
69
0.15
CCL15CCR1Q16663P32246cell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitysignaltransductioncalciumiontransportcalcium-mediatedsignalingcelladhesioncellchemotaxiscellsurfacereceptorsignalingpathwaycytokine-mediatedsignalingpathwaydendriticcellchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerimmuneresponsenegativeregulationofbonemineralizationnegativeregulationofgeneexpressionpositiveregulationofcalciumiontransportpositiveregulationofcellmigrationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofmonocytechemotaxispositiveregulationofosteoclastdifferentiationresponsetowounding
Voltage-dependent anion-selective channel protein 2
76
Voltage-dependent anion-selective channel protein 2
47
9.4
37
0.29
F1S2F6F1S2F6F1S2F6F1S2F6
Insulin receptor
709
Insulin receptor
712
9.3
43
0.25
INSRINSRP06213P06213activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearancecarbohydratemetabolicprocesscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaylearningmalegonaddevelopmentmalesexdeterminationmemoryneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationoftranscriptionDNA-templatedtransmembranereceptorproteintyrosinekinasesignalingpathwaytransportacrossblood-brainbarrierviralentryintohostcell
Solute carrier family 12 member 6
846
Solute carrier family 12 member 6
846
9.6
92
0.11
S12A6S12A6Q9UHW9Q9UHW9ammoniumimportacrossplasmamembraneangiogenesiscellvolumehomeostasiscellularhypotonicresponsecellularhypotonicsalinityresponsecellularresponsetoglucosestimuluschemicalsynaptictransmissionchlorideionhomeostasischloridetransmembranetransportiontransportpotassiumionhomeostasispotassiumionimportacrossplasmamembrane
Isoform Tau-F of Microtubule-associated protein tau
322
Isoform Tau-F of Microtubule-associated protein tau
322
9.6
70
0.15
TAUTAUP10636-8P10636-8
COP9 signalosome complex subunit 3
154
COP9 signalosome complex subunit 8
20
9.3
68
0.16
CSN3CSN8Q9UNS2Q99627inuteroembryonicdevelopmentproteindeneddylationproteinneddylationregulationofDNAdamageresponsesignaltransductionbyp53classmediatorresultingintranscriptionofp21classmediatorregulationofproteinneddylationresponsetolightstimulussignaltransductionubiquitin-dependentproteincatabolicprocessactivationofNF-kappaB-inducingkinaseactivityCOP9signalosomeassemblynegativeregulationofcellpopulationproliferationproteinphosphorylation
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
277
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
72
9.3
72
0.15
STT3ADAD1P46977P61803co-translationalproteinmodificationpost-translationalproteinmodificationproteinN-linkedglycosylationproteinN-linkedglycosylationviaasparagineapoptoticprocessblastocystdevelopmentnegativeregulationofapoptoticprocessproteinglycosylationregulationofproteinstabilityresponsetonutrientresponsetoxenobioticstimulus
Splicing factor 3B subunit 1
1244
Splicing factor 3B subunit 3
1054
9.6
88
0.12
SF3B1SF3B3O75533Q15393chromatinremodelingmRNAsplicingviaspliceosomepositiveregulationofhistoneacetylationpositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIRNAsplicingRNAsplicingviatransesterificationreactionsspliceosomalcomplexassemblyU2-typeprespliceosomeassemblyhistoneH3acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationnegativeregulationofproteincatabolicprocesspositiveregulationoftranscriptionDNA-templatedregulationofDNArepairregulationofRNAsplicing
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
382
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
75
9.4
85
0.13
NDUV1NDUS1P49821P28331aerobicrespirationmitochondrialATPsynthesiscoupledelectrontransportmitochondrialelectrontransportNADHtoubiquinoneprotonmotiveforce-drivenmitochondrialATPsynthesisapoptoticmitochondrialchangesATPmetabolicprocesscellularrespirationmitochondrialrespiratorychaincomplexIassemblyreactiveoxygenspeciesmetabolicprocessregulationofmitochondrialmembranepotential
Clathrin heavy chain 1
1573
Clathrin light chain B
198
9.4
65
0.16
CLH1CLCBP49951P04975amyloid-betaclearancebytranscytosisautophagycelldivisionclathrincoatassemblyclathrin-dependentendocytosisintracellularproteintransportmitoticcellcyclenegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofproteinlocalizationtoplasmamembranereceptorinternalizationreceptor-mediatedendocytosisregulationofmitoticspindleorganizationretrogradetransportendosometoGolgitransferrintransport
Glycoprotein hormones alpha chain
111
Thyrotropin subunit beta
108
9.4
69
0.15
GLHATSHBP01215P01222follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationanatomicalstructuremorphogenesiscell-cellsignalingresponsetocalciumionresponsetoestrogenresponsetovitaminA
DNA-directed RNA polymerase II subunit RPB2
958
DNA-directed RNA polymerases I, II, and III subunit RPABC5
44
9.6
74
0.14
RPB2RPAB5P30876P62875transcriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseItRNAtranscriptionbyRNApolymeraseIII
Cation channel sperm-associated auxiliary subunit delta
384
Cation channel sperm-associated auxiliary subunit epsilon
680
9.0
74
0.15
CTSRDCTSREE9Q9F6P0DP43flagellatedspermmotilityspermcapacitationspermatogenesis
Major prion protein
179
Major prion protein
214
9.6
62
0.17
PRIOPRIOP04273P04273activationofproteinkinaseactivitycalcium-mediatedsignalingusingintracellularcalciumsourcecellcyclecellularresponsetoamyloid-betacellularresponsetocopperioncellularresponsetoxenobioticstimuluslearningormemorynegativeregulationofactivatedTcellproliferationnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofcalcineurin-NFATsignalingcascadenegativeregulationofdendriticspinemaintenancenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofinterferon-gammaproductionnegativeregulationofinterleukin-17productionnegativeregulationofinterleukin-2productionnegativeregulationofproteinphosphorylationnegativeregulationofTcellreceptorsignalingpathwayneuronprojectionmaintenancepositiveregulationofneuronapoptoticprocesspositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteintargetingtomembranepositiveregulationofproteintyrosinekinaseactivityproteindestabilizationproteinhomooligomerizationregulationofcalciumionimportacrossplasmamembraneregulationofglutamatereceptorsignalingpathwayregulationofintracellularcalciumactivatedchloridechannelactivityregulationofpotassiumiontransmembranetransportresponsetooxidativestress
Mucin-2
1117
Mucin-2
1088
9.7
70
0.15
A0A0G2JR65A0A0G2JR65A0A0G2JR65A0A0G2JR65
Excitatory amino acid transporter 3
158
Excitatory amino acid transporter 3
158
9.6
82
0.13
EAA3EAA3P43005P43005activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofproteinkinaseBactivityadultbehaviorbehavioralfearresponsebloodvesselmorphogenesisbraindevelopmentcellularresponsetoammoniumioncellularresponsetobisphenolAcellularresponsetococainecellularresponsetomercuryioncellularresponsetoorganiccycliccompoundcellularzincionhomeostasischemicalsynaptictransmissionchloridetransmembranetransportconditionedplacepreferencecysteinetransportcytokine-mediatedsignalingpathwayD-aspartateimportacrossplasmamembraneD-aspartatetransportdopaminemetabolicprocessdopaminereceptorsignalingpathwaygeneexpressionglutamatehomeostasisglutamatereceptorsignalingpathwayglutathionebiosyntheticprocessgroomingbehaviorheartcontractioniontransportL-aspartateimportacrossplasmamembraneL-aspartatetransmembranetransportL-glutamateimportL-glutamateimportacrossplasmamembraneL-glutamatetransmembranetransportlocomotorybehaviorlong-termsynapticpotentiationmaintenanceofblood-brainbarriermemorymotorbehaviormotorneuronapoptoticprocessnegativeregulationofneuronapoptoticprocessneurogenesisneurondeathinresponsetooxidativestressneurotransmitterreceptortransporttoplasmamembraneneurotransmittertransportpeptidyl-serinephosphorylationpositiveregulationofheartrateregulationofproteintargetingtomembraneresponsetoamphetamineresponsetoanestheticresponsetoaxoninjuryresponsetodecreasedoxygenlevelsresponsetomorphineresponsetoxenobioticstimulusretinalayerformationrightingreflexsuperoxidemetabolicprocesssynapseorganizationtransepithelialtransporttransportacrossblood-brainbarrierzinciontransmembranetransport
Excitatory amino acid transporter 1
186
Excitatory amino acid transporter 1
186
9.6
72
0.14
EAA1EAA1P43003P43003auditorybehaviorcellmorphogenesisinvolvedinneurondifferentiationcellularresponsetococainecellularsodiumionhomeostasischemicalsynaptictransmissionchloridetransmembranetransportcranialnervedevelopmentD-aspartateimportacrossplasmamembranegamma-aminobutyricacidbiosyntheticprocessiontransportL-aspartateimportacrossplasmamembraneL-glutamateimportL-glutamateimportacrossplasmamembraneL-glutamatetransmembranetransportneuromuscularprocesscontrollingbalanceneurotransmittertransportneurotransmitteruptakepositiveregulationofsynaptictransmissionpotassiumiontransmembranetransportresponsetoantibioticresponsetolightstimulusresponsetowoundingresponsetoxenobioticstimulussensoryperceptionofsoundtransepithelialtransporttransportacrossblood-brainbarrier
Solute carrier family 12 member 4
781
Solute carrier family 12 member 4
781
9.3
90
0.12
S12A4S12A4Q9UP95Q9UP95ammoniumimportacrossplasmamembranecellvolumehomeostasischemicalsynaptictransmissionchlorideionhomeostasischloridetransmembranetransportiontransportpotassiumionhomeostasispotassiumionimportacrossplasmamembrane
Glycoprotein hormones alpha chain
83
Choriogonadotropin subunit beta 3
110
9.3
81
0.13
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
ATP synthase lipid-binding protein
99
ATP synthase lipid-binding protein
99
9.6
93
0.11
F1RWF6F1RWF6F1RWF6F1RWF6protonmotiveforce-drivenATPsynthesis
C-C motif chemokine 20
74
C-C chemokine receptor type 6
36
9.0
66
0.17
CCL20CCR6P78556P51684antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecalcium-mediatedsignalingusingintracellularcalciumsourcecellchemotaxiscell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisdefenseresponsetobacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofTcellmigrationsignaltransductionTcellmigrationthymocytemigrationcalcium-mediatedsignalingcellulardefenseresponsedendriticcellchemotaxisDN2thymocytedifferentiationDN3thymocytedifferentiationhumoralimmuneresponseisotypeswitchingtoIgAisotypesleukocytemigrationinvolvedininflammatoryresponselymphocytemigrationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofdendriticcellchemotaxispositiveregulationofflagellatedspermmotilityinvolvedincapacitationregulationofTcellmigration
Sodium channel protein type 9 subunit alpha
1185
Sodium channel subunit beta-1
181
9.0
58
0.19
SCN9ASCN1BQ15858Q07699behavioralresponsetoformalininducedpaininflammatoryresponsemembranedepolarizationduringactionpotentialnegativeregulationofactionpotentialneuronalactionpotentialpost-embryonicdevelopmentregulationofiontransmembranetransportresponsetocoldresponsetoheatresponsetotoxicsubstancesensoryperceptionofpainsodiumiontransmembranetransportsodiumiontransportaxonguidancecardiacconductioncardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractioncelladhesioncorticospinalneuronaxonguidancelocomotionmembranedepolarizationmembranedepolarizationduringcardiacmusclecellactionpotentialmembranedepolarizationduringPurkinjemyocytecellactionpotentialneuronalactionpotentialpropagationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofsodiumiontransportregulationofatrialcardiacmusclecellmembranedepolarizationregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityregulationofventricularcardiacmusclecellmembranerepolarization
DNA-directed RNA polymerase II subunit RPB3
236
DNA-directed RNA polymerases I, II, and III subunit RPABC5
10
9.6
81
0.13
RPB3RPAB5P19387P62875transcriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseItRNAtranscriptionbyRNApolymeraseIII
DNA-directed RNA polymerase II subunit RPB1
1430
DNA-directed RNA polymerase subunit beta
1232
9.4
84
0.13
RPB1I3LGP4P11414I3LGP4positiveregulationofRNAsplicingtranscriptionbyRNApolymeraseII
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
224
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
7.6
96
0.14
NDUV2NDUV1Q9D6J6Q91YT0aerobicrespirationcardiacmuscletissuedevelopmentmitochondrialelectrontransportNADHtoubiquinonenervoussystemdevelopmentprotonmotiveforce-drivenmitochondrialATPsynthesismitochondrialATPsynthesiscoupledelectrontransport
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
382
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
64
9.4
86
0.12
W5PUX0W5QB34W5PUX0W5QB34mitochondrialATPsynthesiscoupledelectrontransportapoptoticmitochondrialchangesATPmetabolicprocessmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyreactiveoxygenspeciesmetabolicprocessregulationofmitochondrialmembranepotential
DNA-directed RNA polymerase I subunit RPA2
93
DNA-directed RNA polymerases I, II, and III subunit RPABC4
36
9.4
58
0.18
RPA2RPAB4Q9H9Y6P53803embryoimplantationneuralcrestformationnucleologenesisrRNAtranscriptionregulationoftranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseIII
C-C motif chemokine 15
93
C-C chemokine receptor type 1
24
7.6
68
0.19
CCL15CCR1Q16663P32246cell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitysignaltransductioncalciumiontransportcalcium-mediatedsignalingcelladhesioncellchemotaxiscellsurfacereceptorsignalingpathwaycytokine-mediatedsignalingpathwaydendriticcellchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerimmuneresponsenegativeregulationofbonemineralizationnegativeregulationofgeneexpressionpositiveregulationofcalciumiontransportpositiveregulationofcellmigrationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofmonocytechemotaxispositiveregulationofosteoclastdifferentiationresponsetowounding
Mediator of RNA polymerase II transcription subunit 11
90
Mediator of RNA polymerase II transcription subunit 22
112
7.6
62
0.21
MED11MED22Q9P086Q15528positiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterpositiveregulationoftranscriptioninitiationfromRNApolymeraseIIpromoterRNApolymeraseIIpreinitiationcomplexassembly
Ion channel TACAN
173
Ion channel TACAN
173
7.7
72
0.18
TACANTACANQ8C1E7Q8C1E7detectionofmechanicalstimulusinvolvedinsensoryperceptionofpainfatcelldifferentiationiontransmembranetransportproteinheterooligomerizationproteinhomooligomerization
C-C motif chemokine 15
93
C-C chemokine receptor type 1
273
9.3
73
0.15
CCL15CCR1Q16663P32246cell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitysignaltransductioncalciumiontransportcalcium-mediatedsignalingcelladhesioncellchemotaxiscellsurfacereceptorsignalingpathwaycytokine-mediatedsignalingpathwaydendriticcellchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerimmuneresponsenegativeregulationofbonemineralizationnegativeregulationofgeneexpressionpositiveregulationofcalciumiontransportpositiveregulationofcellmigrationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofmonocytechemotaxispositiveregulationofosteoclastdifferentiationresponsetowounding
Angiotensin-converting enzyme 2
141
Angiotensin-converting enzyme 2
133
7.6
50
0.26
ACE2ACE2Q9BYF1Q9BYF1angiotensinmaturationangiotensin-mediateddrinkingbehaviorbloodvesseldiametermaintenancematernalprocessinvolvedinfemalepregnancymembranefusionnegativeregulationofERK1andERK2cascadenegativeregulationofsignalingreceptoractivitynegativeregulationofsmoothmusclecellproliferationpositiveregulationofaminoacidtransportpositiveregulationofcardiacmusclecontractionpositiveregulationofgapjunctionassemblypositiveregulationofL-prolineimportacrossplasmamembranepositiveregulationofreactiveoxygenspeciesmetabolicprocessreceptor-mediatedendocytosisofvirusbyhostcellreceptor-mediatedvirionattachmenttohostcellregulationofcardiacconductionregulationofcellpopulationproliferationregulationofcytokineproductionregulationofinflammatoryresponseregulationofsystemicarterialbloodpressurebyrenin-angiotensinregulationoftransmembranetransporteractivityregulationofvasoconstrictiontryptophantransportviralentryintohostcellvirallifecycle
Immunoglobulin heavy constant mu
291
Polymeric immunoglobulin receptor
486
7.6
43
0.31
IGHMPIGRP01871P01833adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationdetectionofchemicalstimulusinvolvedinsensoryperceptionofbittertasteepidermalgrowthfactorreceptorsignalingpathwayFcreceptorsignalingpathwayimmunoglobulintranscytosisinepithelialcellsmediatedbypolymericimmunoglobulinreceptorreceptorclusteringretinahomeostasis
Glycoprotein hormones alpha chain
111
Choriogonadotropin subunit beta 3
113
7.6
76
0.17
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
28S ribosomal protein S16, mitochondrial
26
28S ribosomal protein S25, mitochondrial
149
3.7
50
0.54
RT16RT25P82915P82669mitochondrialtranslation
Transformation/transcription domain-associated protein
2639
Transcriptional adapter 1
263
7.8
81
0.16
F2Z2U4TADA1F2Z2U4Q96BN2histoneacetylationphosphorylationpositiveregulationofresponsetostimulusregulationofcellularresponsetostressregulationofmacromoleculemetabolicprocessregulationofnucleobase-containingcompoundmetabolicprocesshistoneH3acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationpositiveregulationoftranscriptionDNA-templatedregulationofDNArepairregulationofRNAsplicingregulationoftranscriptionbyRNApolymeraseII
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
fMet-Leu-Phe receptor
126
3.7
79
0.34
GNAI1FPR1P63096P21462adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormonechemotaxiscomplementreceptormediatedsignalingpathwayinflammatoryresponsenitricoxidemediatedsignaltransductionphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationsignaltransduction
Potassium voltage-gated channel subfamily D member 2
111
Potassium voltage-gated channel subfamily D member 2
132
3.7
70
0.39
KCND2KCND2Q9NZV8Q9NZV8actionpotentialcellularresponsetohypoxiachemicalsynaptictransmissionlocomotorrhythmneuronalactionpotentialpotassiumiontransmembranetransportproteinhomooligomerizationregulationofiontransmembranetransportsensoryperceptionofpain
Glial cell line-derived neurotrophic factor
149
Glial cell line-derived neurotrophic factor
178
7.8
52
0.25
GDNFGDNFP39905P39905adultlocomotorybehaviorbranchinginvolvedinuretericbudmorphogenesiscommissuralneuronaxonguidancedorsalspinalcorddevelopmentembryonicorgandevelopmententericnervoussystemdevelopmentmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesismetanephrosdevelopmentmRNAstabilizationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofneuronapoptoticprocessnervoussystemdevelopmentneuralcrestcellmigrationneuronprojectiondevelopmentorganinductionperipheralnervoussystemdevelopmentperistalsispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofdopaminesecretionpositiveregulationofmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesispositiveregulationofmonooxygenaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofuretericbudformationpostganglionicparasympatheticfiberdevelopmentpostsynapticmembraneorganizationregulationofdopamineuptakeinvolvedinsynaptictransmissionregulationofgeneexpressionregulationofmorphogenesisofabranchingstructureregulationofsemaphorin-plexinsignalingpathwayregulationofstemcelldifferentiationsignaltransductionsympatheticnervoussystemdevelopmenturetericbudformation
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
286
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
225
7.8
87
0.15
NDUV1NDUV2P49821P19404aerobicrespirationmitochondrialATPsynthesiscoupledelectrontransportmitochondrialelectrontransportNADHtoubiquinoneprotonmotiveforce-drivenmitochondrialATPsynthesiscardiacmuscletissuedevelopmentnervoussystemdevelopment
Glycoprotein hormones alpha chain
111
Choriogonadotropin subunit beta 3
120
7.8
89
0.14
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
Neuronal acetylcholine receptor subunit beta-4
260
Neuronal acetylcholine receptor subunit beta-4
260
7.9
66
0.19
ACHB4ACHB4P30926P30926behavioralresponsetonicotinechemicalsynaptictransmissioniontransmembranetransportiontransportlocomotorybehaviormembranedepolarizationnervoussystemprocessneuronalactionpotentialpositiveregulationoftransmissionofnerveimpulseregulationofmembranepotentialregulationofneurotransmittersecretionregulationofsmoothmusclecontractionsignaltransductionsmoothmusclecontractionsynaptictransmissioninvolvedinmicturitionsynaptictransmissioncholinergic
Protein tweety homolog 2
101
Protein tweety homolog 2
101
7.9
58
0.22
TTYH2TTYH2Q9BSA4Q9BSA4
Glutamate receptor ionotropic, delta-1
351
Glutamate receptor ionotropic, delta-1
351
7.9
70
0.18
GRID1GRID1Q62640Q62640modulationofchemicalsynaptictransmissionsocialbehaviorsynaptictransmissionglutamatergic
Mediator of RNA polymerase II transcription subunit 17
649
Mediator of RNA polymerase II transcription subunit 28
93
7.9
62
0.2
MED17MED28Q9NVC6Q9H204positiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterpositiveregulationoftranscriptioninitiationfromRNApolymeraseIIpromoterpositiveregulationoftranscriptionDNA-templatedregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblysomaticstemcellpopulationmaintenancetranscriptioninitiationfromRNApolymeraseIIpromoternegativeregulationofsmoothmusclecelldifferentiation
Potassium voltage-gated channel subfamily C member 1
105
Potassium voltage-gated channel subfamily C member 1
83
3.7
67
0.4
KCNC1KCNC1P48547P48547cellularresponsetoxenobioticstimuluscerebellumdevelopmentglobuspallidusdevelopmentpositiveregulationofvoltage-gatedpotassiumchannelactivitypotassiumiontransmembranetransportpotassiumiontransportproteinhomooligomerizationproteintetramerizationresponsetoamineresponsetoauditorystimulusresponsetofibroblastgrowthfactorresponsetolightintensityresponsetonervegrowthfactorresponsetopotassiumionresponsetotoxicsubstance
WD repeat and HMG-box DNA-binding protein 1
598
WD repeat and HMG-box DNA-binding protein 1
598
7.8
88
0.15
WDHD1WDHD1O75717O75717DNArepairDNA-templatedDNAreplicationmitoticcellcycle
C-C motif chemokine 20
33
C-C chemokine receptor type 6
36
7.8
69
0.18
CCL20CCR6P78556P51684antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecalcium-mediatedsignalingusingintracellularcalciumsourcecellchemotaxiscell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisdefenseresponsetobacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofTcellmigrationsignaltransductionTcellmigrationthymocytemigrationcalcium-mediatedsignalingcellulardefenseresponsedendriticcellchemotaxisDN2thymocytedifferentiationDN3thymocytedifferentiationhumoralimmuneresponseisotypeswitchingtoIgAisotypesleukocytemigrationinvolvedininflammatoryresponselymphocytemigrationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofdendriticcellchemotaxispositiveregulationofflagellatedspermmotilityinvolvedincapacitationregulationofTcellmigration
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
Cannabinoid receptor 2
134
3.7
80
0.34
GNAI1CNR2P63096P34972adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormoneadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycannabinoidsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerimmuneresponseinflammatoryresponseleukocytechemotaxisnegativeregulationofactionpotentialnegativeregulationofinflammatoryresponsenegativeregulationofmastcellactivationnegativeregulationofnitric-oxidesynthaseactivitynegativeregulationofsynaptictransmissionGABAergicregulationofmetabolicprocessresponsetoamphetamineresponsetolipopolysaccharidesensoryperceptionofpain
Glutamate receptor 1
75
Glutamate receptor
330
7.8
70
0.18
GRIA1G5E8H1P23818G5E8H1cellularresponsetoammoniumionchemicalsynaptictransmissionlong-termmemorylong-termsynapticdepressionmodulationofchemicalsynaptictransmissionneuronalactionpotentialpositiveregulationofmembranepotentialpositiveregulationofsynaptictransmissionreceptorinternalizationregulationofpostsynapticmembranepotentialregulationofreceptorrecyclingregulationofsynapticplasticityresponsetotoxicsubstance
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
150
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
183
7.8
95
0.13
NDUS8NDUS7O00217O75251aerobicrespirationmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyprotonmotiveforce-drivenmitochondrialATPsynthesisresponsetooxidativestresselectrontransportcoupledprotontransport
T-cell surface glycoprotein CD3 delta chain
93
T-cell surface glycoprotein CD3 epsilon chain
122
3.7
60
0.45
CD3DCD3EP04234P07766adaptiveimmuneresponsealpha-betaTcellactivationcellsurfacereceptorsignalingpathwaypositivethymicTcellselectionTcellreceptorsignalingpathwayapoptoticsignalingpathwaycalcium-mediatedsignalingCD4-positivealpha-betaTcellproliferationcerebellumdevelopmentdendritedevelopmentGprotein-coupledreceptorsignalingpathwaygamma-deltaTcellactivationnegativeregulationofgeneexpressionnegativeregulationofsmoothenedsignalingpathwaynegativethymicTcellselectionpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofgeneexpressionpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofTcellanergypositiveregulationofTcellproliferationprotein-containingcomplexassemblyregulationofapoptoticprocesssignalcomplexassemblysmoothenedsignalingpathwayTcellactivationTcellanergyTcellcostimulationtransmembranereceptorproteintyrosinekinasesignalingpathway
Glutamate receptor
350
Glutamate receptor
350
7.8
70
0.18
G3V9I2G3V9I2G3V9I2G3V9I2
Glycoprotein hormones alpha chain
55
Choriogonadotropin subunit beta 3
58
7.8
77
0.17
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
Insulin receptor
551
Insulin receptor
712
7.8
50
0.26
INSRINSRP06213P06213activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearancecarbohydratemetabolicprocesscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaylearningmalegonaddevelopmentmalesexdeterminationmemoryneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationoftranscriptionDNA-templatedtransmembranereceptorproteintyrosinekinasesignalingpathwaytransportacrossblood-brainbarrierviralentryintohostcell
Potassium voltage-gated channel, Shaw-related subfamily, member 1
105
Potassium voltage-gated channel, Shaw-related subfamily, member 1
83
3.2
69
0.45
Q3KNS8Q3KNS8Q3KNS8Q3KNS8proteinhomooligomerizationregulationofiontransmembranetransport
Potassium voltage-gated channel subfamily D member 2
132
Potassium voltage-gated channel subfamily D member 2
111
3.6
66
0.42
A0A6P6DHQ6A0A6P6DHQ6A0A6P6DHQ6A0A6P6DHQ6proteinhomooligomerizationregulationofiontransmembranetransport
Potassium voltage-gated channel subfamily D member 2
133
Potassium voltage-gated channel subfamily D member 2
111
3.5
64
0.45
KCND2KCND2Q9NZV8Q9NZV8actionpotentialcellularresponsetohypoxiachemicalsynaptictransmissionlocomotorrhythmneuronalactionpotentialpotassiumiontransmembranetransportproteinhomooligomerizationregulationofiontransmembranetransportsensoryperceptionofpain
Igh protein
308
Igh protein
306
3.4
51
0.58
Q99M22Q99M22Q99M22Q99M22
ATPase GET3
292
ATPase GET3
289
3.5
70
0.41
GET3GET3O43681O43681post-translationalproteintargetingtoendoplasmicreticulummembraneproteininsertionintoERmembranetail-anchoredmembraneproteininsertionintoERmembrane
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
225
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
6.5
99
0.15
NDUV2NDUV1P04394P25708cardiacmuscletissuedevelopmentmitochondrialelectrontransportNADHtoubiquinonenervoussystemdevelopment
DNA replication licensing factor MCM3
243
DNA replication licensing factor MCM5
219
3.5
71
0.41
MCM3MCM5P25205P33992DNAreplicationinitiationDNAstrandelongationinvolvedinDNAreplicationDNAunwindinginvolvedinDNAreplicationdouble-strandbreakrepairviabreak-inducedreplicationmitoticDNAreplicationinitiationregulationofDNA-templatedDNAreplicationinitiationcellcycleDNAreplication
Histone H3
111
Histone H3
111
6.5
82
0.19
A0A6I9KHI6A0A6I9KHI6A0A6I9KHI6A0A6I9KHI6
Broad substrate specificity ATP-binding cassette transporter ABCG2
544
Broad substrate specificity ATP-binding cassette transporter ABCG2
438
6.6
90
0.17
ABCG2ABCG2Q9UNQ0Q9UNQ0biotintransportcellulardetoxificationexportacrossplasmamembranelipidtransportorganicaniontransportrenaluratesaltexcretionriboflavintransporttransepithelialtransporttransmembranetransporttransportacrossblood-brainbarrieruratemetabolicprocessxenobiotictransportacrossblood-brainbarrier
Pentraxin-related protein PTX3
317
Pentraxin-related protein PTX3
317
3.1
65
0.49
PTX3PTX3P26022P26022extracellularmatrixorganizationinflammatoryresponseinnateimmuneresponsenegativeregulationbyhostofviralexo-alpha-sialidaseactivitynegativeregulationbyhostofviralglycoproteinmetabolicprocessnegativeregulationbyhostofviralprocessnegativeregulationofexo-alpha-sialidaseactivitynegativeregulationofglycoproteinmetabolicprocessnegativeregulationofviralentryintohostcellopsonizationovariancumulusexpansionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphagocytosisresponsetoyeast
Potassium voltage-gated channel, Shaw-related subfamily, member 1
83
Potassium voltage-gated channel, Shaw-related subfamily, member 1
78
6.5
77
0.2
Q3KNS8Q3KNS8Q3KNS8Q3KNS8proteinhomooligomerizationregulationofiontransmembranetransport
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
141
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
155
3.3
77
0.39
NDUBBNDUBAQ8HXG5Q02373mitochondrialrespiratorychaincomplexIassembly
ATPase GET3
292
ATPase GET3
292
3.3
79
0.38
GET3GET3O43681O43681post-translationalproteintargetingtoendoplasmicreticulummembraneproteininsertionintoERmembranetail-anchoredmembraneproteininsertionintoERmembrane
Glutamate receptor ionotropic, kainate 3
99
Glutamate receptor ionotropic, kainate 3
99
7.9
63
0.2
GRIK3GRIK3P42264P42264chemicalsynaptictransmissionGprotein-coupledglutamatereceptorsignalingpathwayglutamatereceptorsignalingpathwaymodulationofchemicalsynaptictransmissionnegativeregulationofsynaptictransmissionglutamatergicregulationofmembranepotentialsynaptictransmissionglutamatergic
DNA-directed RNA polymerase III subunit RPC2
919
DNA-directed RNA polymerases I, II, and III subunit RPABC5
10
7.9
95
0.13
RPC2RPAB5Q9NW08P62875defenseresponsetovirusinnateimmuneresponsepositiveregulationofinnateimmuneresponsepositiveregulationofinterferon-betaproductiontranscriptionDNA-templatedregulationoftranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseIItRNAtranscriptionbyRNApolymeraseIII
Insulin
96
Insulin
31
3.5
61
0.47
INSINSP01308P01318activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealingcellularresponsetopalmitoleicacidresponsetoL-arginine
Transmembrane protein 120B
169
Transmembrane protein 120B
169
7.9
66
0.19
T120BT120BA0PK00A0PK00fatcelldifferentiationproteinheterooligomerization
NADH-ubiquinone oxidoreductase chain 6
16
NADH-ubiquinone oxidoreductase chain 4L
32
7.9
96
0.13
A9UIY5NU4LMA9UIY5P03903aerobicrespirationATPsynthesiscoupledelectrontransportprotonmotiveforce-drivenmitochondrialATPsynthesis
Neutral and basic amino acid transport protein rBAT
114
b(0,+)-type amino acid transporter 1
144
3.5
53
0.53
SLC31BAT1Q07837P82251aminoacidtransportaspartatetransmembranetransportbasicaminoacidtransportcarbohydratemetabolicprocessgeneexpressionL-cystinetransportL-glutamatetransmembranetransportneutralaminoacidtransportprotein-containingcomplexassembly
N-formyl peptide receptor 2
126
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
7.9
73
0.17
FPR2GNAI1P25090P63096adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayastrocyteactivationcalcium-mediatedsignalingcelladhesioncellsurfacereceptorsignalingpathwaycellularresponsetoamyloid-betachemotaxiscomplementreceptormediatedsignalingpathwaydefenseresponsetobacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponse-regulatingcellsurfacereceptorsignalingpathwayinflammatoryresponsemicroglialcellactivationnegativeregulationofinflammatoryresponsephospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositivechemotaxispositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofinnateimmuneresponsepositiveregulationofmonocytechemotaxispositiveregulationofphagocytosispositiveregulationofproteinphosphorylationpositiveregulationofsuperoxideaniongenerationreceptor-mediatedendocytosisadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinpositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormone
Toll-like receptor 5
646
Toll-like receptor 5
646
9.3
45
0.24
TLR5TLR5O60602O60602cellularresponsetomechanicalstimulusdefenseresponsetobacteriuminflammatoryresponseinnateimmuneresponseMyD88-dependenttoll-likereceptorsignalingpathwaypositiveregulationofinterleukin-8productionpositiveregulationoftoll-likereceptorsignalingpathwaytoll-likereceptor5signalingpathwaytoll-likereceptorsignalingpathway
28S ribosomal protein S6, mitochondrial
105
28S ribosomal protein S18c, mitochondrial
66
7.5
48
0.28
RT06RT18CP82931P82917mitochondrialtranslationtranslation
Clathrin heavy chain
1573
Clathrin light chain
188
7.5
48
0.28
C0MHR2F1S398C0MHR2F1S398clathrincoatassemblyintracellularproteintransportmitoticcellcyclereceptor-mediatedendocytosisclathrin-dependentendocytosis
Glutamate receptor 2
78
Glutamate receptor 1
323
7.5
73
0.18
GRIA2GRIA1P19491P19490chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumioncellularresponsetoaminestimuluscellularresponsetoaminoacidstimuluscellularresponsetoammoniumioncellularresponsetodsRNAcellularresponsetogrowthfactorstimuluscellularresponsetoorganiccycliccompoundcellularresponsetopeptidehormonestimuluslong-termmemorylong-termsynapticdepressionmodulationofchemicalsynaptictransmissionneuronalactionpotentialpositiveregulationofmembranepotentialregulationofpostsynapticmembranepotentialregulationofsynapticplasticityresponsetoarsenic-containingsubstanceresponsetococaineresponsetoelectricalstimulusresponsetoestradiolresponsetoorganiccycliccompoundresponsetopeptidehormoneresponsetotoxicsubstanceresponsetoxenobioticstimulusspinalcorddevelopmentsynaptictransmissionglutamatergic
Cysteine desulfurase, mitochondrial
381
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
130
9.2
78
0.14
NFS1ISCUQ9Y697Q9H1K12Fe-2Sclusterassemblyironincorporationintometallo-sulfurclusteriron-sulfurclusterassemblyMo-molybdopterincofactorbiosyntheticprocesscellularironionhomeostasisnegativeregulationofironionimportacrossplasmamembranepositiveregulationofaconitatehydrataseactivitypositiveregulationofmitochondrialelectrontransportNADHtoubiquinone
Sodium channel subunit beta-2
55
Sodium channel protein type 2 subunit alpha
912
9.2
63
0.17
SCN2BSCN2AO60939Q99250cardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractionchemicalsynaptictransmissiongeneexpressionmembranedepolarizationduringcardiacmusclecellactionpotentialnervoussystemdevelopmentregulationofatrialcardiacmusclecellmembranedepolarizationregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityresponsetoheatresponsetopyrethroidsodiumiontransmembranetransportcellularresponsetohypoxiaintrinsicapoptoticsignalingpathwayinresponsetoosmoticstressmembranedepolarizationduringactionpotentialmemorymyelinationneuronapoptoticprocessneuronalactionpotentialregulationofiontransmembranetransportsodiumiontransport
Pro-adrenomedullin
115
Calcitonin gene-related peptide type 1 receptor
299
9.2
69
0.16
ADMLCALRLP35318Q16602adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadrenomedullinreceptorsignalingpathwayagingamylinreceptorsignalingpathwayandrogenmetabolicprocessanimalorganregenerationantibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidebranchinginvolvedinlabyrinthinelayermorphogenesiscalciumionhomeostasiscAMP-mediatedsignalingcellpopulationproliferationdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdevelopmentalgrowthfemalepregnancyGprotein-coupledreceptorinternalizationheartdevelopmenthormonesecretioninflammatoryresponsenegativeregulationofcellpopulationproliferationnegativeregulationofvascularpermeabilitynegativeregulationofvasoconstrictionneuraltubeclosureneuronprojectionregenerationodontogenesisofdentin-containingtoothpositiveregulationofangiogenesispositiveregulationofapoptoticprocesspositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofheartratepositiveregulationofprogesteronebiosyntheticprocesspositiveregulationofvasculogenesisreceptorinternalizationregulationofsystemicarterialbloodpressureregulationoftheforceofheartcontractionregulationofurinevolumeresponsetocoldresponsetoglucocorticoidresponsetohypoxiaresponsetoinsulinresponsetolipopolysaccharideresponsetostarvationresponsetowoundingsignaltransductionspongiotrophoblastlayerdevelopmentvascularassociatedsmoothmusclecelldevelopmentvasculogenesisadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwayangiogenesiscalcitoningene-relatedpeptidereceptorsignalingpathwaycalciumiontransportcellsurfacereceptorsignalingpathwaycellularresponsetosucrosestimulusGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengernegativeregulationofinflammatoryresponsenegativeregulationofsmoothmusclecontractionpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteintransportvascularassociatedsmoothmusclecellproliferation
General transcription factor IIH subunit 3
282
General transcription factor IIH subunit 2
247
7.6
72
0.18
TF2H3TF2H2Q13889Q13888DNArepairnucleotide-excisionrepairphosphorylationofRNApolymeraseIIC-terminaldomaintranscriptionbyRNApolymeraseIIGprotein-coupledreceptorinternalizationpositiveregulationofDNAhelicaseactivityregulationoftranscriptionbyRNApolymeraseIIresponsetoUVtranscriptioninitiationfromRNApolymeraseIIpromoter
ATP synthase lipid-binding protein
125
ATP synthase lipid-binding protein
125
9.3
88
0.12
Q4VT52Q4VT52Q4VT52Q4VT52protonmotiveforce-drivenATPsynthesis
THO complex subunit 5 homolog
59
THO complex subunit 7 homolog
60
7.5
69
0.19
THOC5THOC7Q13769Q6I9Y2monocytedifferentiationmRNAexportfromnucleusmRNAprocessingnegativeregulationofDNAdamagecheckpointpositiveregulationofDNA-templatedtranscriptionelongationprimitivehemopoiesisRNAsplicingviralmRNAexportfromhostcellnucleus
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
Adhesion G-protein coupled receptor F1
626
9.3
73
0.15
GNAI1AGRF1P63096Q5T601adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormoneadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycellsurfacereceptorsignalingpathwaymemoryneuronprojectiondevelopmentpositiveregulationofCREBtranscriptionfactoractivitysynapseassembly
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
153
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
183
8.1
98
0.13
NDUS8NDUS7O00217O75251aerobicrespirationmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyprotonmotiveforce-drivenmitochondrialATPsynthesisresponsetooxidativestresselectrontransportcoupledprotontransport
THO complex subunit 2
503
THO complex subunit 3
258
3.6
84
0.33
THOC2THOC3Q8NI27Q96J01blastocystdevelopmentcellmorphogenesisgenerationofneuronsmRNAexportfromnucleusmRNAprocessingnegativeregulationofneuronprojectiondevelopmentneurondevelopmentpoly(A)+mRNAexportfromnucleusregulationofgeneexpressionregulationofmRNAexportfromnucleusRNAsplicingstemcelldivisionviralmRNAexportfromhostcellnucleus
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
Neuropeptide Y receptor type 2
151
3.7
71
0.38
GNAI1NPY2RP63096P49146adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormonecardiacleftventriclemorphogenesislocomotorybehavioroutflowtractmorphogenesis
Cytochrome c oxidase subunit 7C, mitochondrial
42
Cytochrome c oxidase subunit 8A, mitochondrial
47
8.1
66
0.19
COX7CCOX8AP15954P10176cellularrespirationgenerationofprecursormetabolitesandenergymitochondrialelectrontransportcytochromectooxygen
DNA-directed RNA polymerase II subunit RPB3
236
DNA-directed RNA polymerases I, II, and III subunit RPABC5
45
8.1
84
0.15
RPB3RPAB5P19387P62875transcriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseItRNAtranscriptionbyRNApolymeraseIII
DNA-directed RNA polymerase III subunit RPC1
113
DNA-directed RNA polymerase III subunit RPC3
79
8.1
75
0.17
RPC1RPC3O14802Q9BUI4defenseresponsetovirusinnateimmuneresponsepositiveregulationofinterferon-betaproductiontranscriptionDNA-templatedpositiveregulationofinnateimmuneresponseregulationoftranscriptionbyRNApolymeraseIII
RuvB-like 1
206
Actin-related protein 6
339
8.1
57
0.22
RUVB1ARP6Q9Y265Q9GZN1boxC/DsnoRNPassemblycellcyclecelldivisionchromatinremodelingDNArecombinationDNArepairhistoneacetylationhistoneexchangehistoneH2AacetylationhistoneH4acetylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationoftelomeraseRNAlocalizationtoCajalbodypositiveregulationoftelomeremaintenanceinresponsetoDNAdamagepositiveregulationoftranscriptionDNA-templatedproteinstabilizationregulationofapoptoticprocessregulationofcellcycleregulationofchromosomeorganizationregulationofDNAreplicationregulationofDNAstrandelongationregulationofdouble-strandbreakrepairregulationofembryonicdevelopmentregulationofgrowthregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedspermatogenesistelomeremaintenancenegativeregulationoftranscriptionbyRNApolymeraseInucleolusorganizationpositiveregulationoftranscriptionbyRNApolymeraseI
Glutamate receptor ionotropic, NMDA 1
79
Glutamate receptor ionotropic, NMDA 2A
87
8.1
65
0.19
NMDZ1NMDE1P35439Q00959adultlocomotorybehaviorassociativelearningcalciumionhomeostasiscalciumiontransmembraneimportintocytosolcalciumiontransportcationtransmembranetransportcationtransportcellularcalciumionhomeostasiscellularresponsetomanganeseioncerebralcortexdevelopmentchemicalsynaptictransmissionconditionedtasteaversionexcitatorypostsynapticpotentialionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylong-termmemorymalematingbehaviormemorynegativeregulationofneuronapoptoticprocessneuromuscularprocessolfactorylearningponsmaturationpositiveregulationofapoptoticprocesspositiveregulationofcalciumiontransportintocytosolpositiveregulationofcelldeathpositiveregulationofcysteine-typeendopeptidaseactivitypositiveregulationofdendriticspinemaintenancepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofSchwanncellmigrationpositiveregulationofsynaptictransmissionglutamatergicpositiveregulationoftranscriptionbyRNApolymeraseIIprepulseinhibitionpropylenemetabolicprocessproteinheterotetramerizationproteinlocalizationtopostsynapticmembraneprotein-containingcomplexassemblyregulationofaxonogenesisregulationofcationtransmembranetransportregulationofcellcommunicationregulationofdendritemorphogenesisregulationoflong-termneuronalsynapticplasticityregulationofmembranepotentialregulationofneuronapoptoticprocessregulationofneuronalsynapticplasticityregulationofrespiratorygaseousexchangeregulationofsynapseassemblyregulationofsynapticplasticityresponsetoamineresponsetoamphetamineresponsetocalciumionresponsetoethanolresponsetofungicideresponsetoglycineresponsetomorphineresponsetoorganiccycliccompoundrhythmicprocesssensoryperceptionofpainsocialbehaviorstartleresponsesucklingbehaviorsynaptictransmissionglutamatergicvisuallearningactionpotentialcellularresponsetoaminoacidstimuluscellularresponsetodsRNAcellularresponsetogrowthfactorstimuluscellularresponsetolipidcellularresponsetomagnesiumioncellularresponsetozinciondendriticspineorganizationdirectionallocomotiondopaminemetabolicprocesshippocampusdevelopmentlocomotionlong-termsynapticpotentiationmodulationofchemicalsynaptictransmissionnegativeregulationofproteincatabolicprocessneurogenesisregulationofNMDAreceptoractivityregulationofpostsynapticmembranepotentialresponsetoammoniumionresponsetocarbohydrateresponsetococaineresponsetolightstimulusresponsetomanganeseionresponsetomethylmercuryresponsetootherorganismresponsetowoundingresponsetoxenobioticstimulusserotoninmetabolicprocesssleepspinalcorddevelopment
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
69
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
130
3.6
90
0.3
ISCUISCUQ9H1K1Q9H1K1cellularironionhomeostasisiron-sulfurclusterassemblynegativeregulationofironionimportacrossplasmamembranepositiveregulationofaconitatehydrataseactivitypositiveregulationofmitochondrialelectrontransportNADHtoubiquinone
Dipeptidyl peptidase 9
844
NACHT, LRR and PYD domains-containing protein 1
1288
9.3
63
0.17
DPP9NLRP1Q86TI2Q9C000proteolysispyroptosisactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessantiviralinnateimmuneresponseapoptoticprocessdefenseresponsetobacteriumdefenseresponsetovirusinflammatoryresponseneuronapoptoticprocessNLRP1inflammasomecomplexassemblypatternrecognitionreceptorsignalingpathwaypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionproteinhomooligomerizationregulationofapoptoticprocessregulationofinflammatoryresponseresponsetomuramyldipeptideselfproteolysis
Immunoglobulin heavy constant alpha 1
352
Immunoglobulin J chain
35
9.3
65
0.17
IGHA1IGJP01876P01591adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasishumoralimmuneresponseprotein-containingcomplexassembly
Hepcidin
66
Solute carrier family 40 member 1
326
8.0
79
0.16
HEPCS40A1P81172Q9NP59acute-phaseresponseagingantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularironionhomeostasiscellularresponsetobileacidcellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactorcellularresponsetoX-raydefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumestablishmentoflocalizationincellimmuneresponseironiontransmembranetransportkillingofcellsofanotherorganismliverregenerationmacrophageactivationmulticellularorganismalironionhomeostasismyeloidcellhomeostasisnegativeregulationofboneresorptionnegativeregulationofinflammatoryresponsenegativeregulationofintestinalabsorptionnegativeregulationofiontransmembranetransporteractivitynegativeregulationofironexportacrossplasmamembranenegativeregulationofironiontransmembranetransportnegativeregulationofironiontransmembranetransporteractivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofmacrophageactivationpositiveregulationofproteincatabolicprocesspositiveregulationofproteinpolyubiquitinationpositiveregulationofreceptorcatabolicprocesspositiveregulationofreceptorinternalizationpositiveregulationoftranscriptionbyRNApolymeraseIIproteincatabolicprocessreceptorsignalingpathwayviaJAK-STATresponsetoerythropoietinresponsetoethanolresponsetoironionresponsetoironionstarvationresponsetovitaminAresponsetozinciontranscriptionbyRNApolymeraseIIapoptoticprocessendotheliumdevelopmentironionexportacrossplasmamembraneironionhomeostasislymphocytehomeostasisnegativeregulationofapoptoticprocessregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoironspleentrabeculaformation
C-C chemokine receptor type 2
75
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
9.0
65
0.17
CCR2GNAI1P41597P63096bloodvesselremodelingcalcium-mediatedsignalingcellchemotaxiscellularcalciumionhomeostasiscellulardefenseresponsecellularhomeostasischemokine-mediatedsignalingpathwaychemotaxiscytokine-mediatedsignalingpathwaydendriticcellchemotaxisimmuneresponseinflammatoryresponseinflammatoryresponsetowoundingmacrophagemigrationmonocyteextravasationnegativeregulationofadenylatecyclaseactivitynegativeregulationofangiogenesisnegativeregulationofeosinophildegranulationnegativeregulationoftype2immuneresponsepositiveregulationofalpha-betaTcellproliferationpositiveregulationofastrocytechemotaxispositiveregulationofCD8-positivealpha-betaTcellextravasationpositiveregulationofcold-inducedthermogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofhematopoieticstemcellmigrationpositiveregulationofimmunecomplexclearancebymonocytesandmacrophagespositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-2productionpositiveregulationofmonocytechemotaxispositiveregulationofmonocyteextravasationpositiveregulationofNMDAglutamatereceptoractivitypositiveregulationofsynaptictransmissionglutamatergicpositiveregulationofTcellactivationpositiveregulationofTcellchemotaxispositiveregulationofT-helper1typeimmuneresponsepositiveregulationofthymocytemigrationpositiveregulationoftumornecrosisfactorproductionreceptorsignalingpathwayviaJAK-STATregulationofinflammatoryresponseregulationofTcellcytokineproductionregulationofTcelldifferentiationregulationofvascularendothelialgrowthfactorproductionresponsetowoundingsensoryperceptionofpainT-helper17cellchemotaxisadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormone
Interleukin-17A
99
Interleukin-17A
99
9.7
78
0.13
IL17IL17Q16552Q16552adaptiveimmuneresponseapoptoticprocesscelldeathcell-cellsignalingcellularresponsetointerleukin-1defenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumfibroblastactivationgranulocytemigrationimmuneresponseinflammatoryresponseinnateimmuneresponseinterleukin-17-mediatedsignalingpathwayintestinalepithelialstructuremaintenanceNotchsignalingpathwaypositiveregulationofantimicrobialpeptideproductionpositiveregulationofbicellulartightjunctionassemblypositiveregulationofchemokine(C-X-Cmotif)ligand1productionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-16productionpositiveregulationofinterleukin-23productionpositiveregulationofinterleukin-6productionpositiveregulationofosteoclastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproduction
B-cell lymphoma/leukemia 10
57
B-cell lymphoma/leukemia 10
57
9.7
46
0.22
BCL10BCL10O95999O95999adaptiveimmuneresponseantifungalinnateimmuneresponseBcellapoptoticprocesscelldeathcellulardefenseresponsecellularresponsetolipopolysaccharidecellularresponsetomechanicalstimulusI-kappaBkinase/NF-kappaBsignalingimmunoglobulinmediatedimmuneresponseinnateimmuneresponselipopolysaccharide-mediatedsignalingpathwaynegativeregulationofmatureBcellapoptoticprocessneuraltubeclosurepositiveregulationofapoptoticprocesspositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofkinaseactivitypositiveregulationoflymphotoxinAproductionpositiveregulationofmastcellcytokineproductionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofphosphorylationpositiveregulationofproteinubiquitinationpositiveregulationofTcellactivationpositiveregulationofTcellreceptorsignalingpathwaypositiveregulationoftranscriptionDNA-templatedproteinhomooligomerizationresponsetofoodTcellapoptoticprocessTcellreceptorsignalingpathwaytoll-likereceptorsignalingpathway
N-formyl peptide receptor 2
63
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
9.8
77
0.13
FPR2GNAI1P25090P63096adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayastrocyteactivationcalcium-mediatedsignalingcelladhesioncellsurfacereceptorsignalingpathwaycellularresponsetoamyloid-betachemotaxiscomplementreceptormediatedsignalingpathwaydefenseresponsetobacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponse-regulatingcellsurfacereceptorsignalingpathwayinflammatoryresponsemicroglialcellactivationnegativeregulationofinflammatoryresponsephospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositivechemotaxispositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofinnateimmuneresponsepositiveregulationofmonocytechemotaxispositiveregulationofphagocytosispositiveregulationofproteinphosphorylationpositiveregulationofsuperoxideaniongenerationreceptor-mediatedendocytosisadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinpositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormone
COP9 signalosome complex subunit 4
378
COP9 signalosome complex subunit 6
266
9.8
70
0.15
CSN4CSN6Q9BT78Q7L5N1proteindeneddylationproteinneddylationregulationofproteinneddylation
Lys-63-specific deubiquitinase BRCC36
156
BRISC complex subunit Abraxas 2
14
9.8
83
0.12
BRCC3ABRX2P46736Q15018celldivisioncellularresponsetoionizingradiationchromatinorganizationdouble-strandbreakrepairhistoneH2AK63-linkeddeubiquitinationhistoneH2AmonoubiquitinationmitoticG2DNAdamagecheckpointsignalingmitoticG2/MtransitioncheckpointpositiveregulationofDNArepairproteinautoubiquitinationproteindeubiquitinationproteinK63-linkeddeubiquitinationregulationofDNAdamagecheckpointregulationofDNArepairresponsetoionizingradiationresponsetoX-rayattachmentofspindlemicrotubulestokinetochorechromosomesegregationmitoticcellcyclemitoticspindleassemblyresponsetoischemia
Transmembrane protein 106B
214
Transmembrane protein 106B
214
9.8
60
0.17
T106BT106BQ9NUM4Q9NUM4dendritemorphogenesislysosomallumenacidificationlysosomalproteincatabolicprocesslysosomaltransportlysosomelocalizationlysosomeorganizationneuroncellularhomeostasispositiveregulationofdendritedevelopmentpositiveregulationofhydrolaseactivityregulationoflysosomeorganization
Immunoglobulin J chain
35
Immunoglobulin heavy constant alpha 2
339
9.8
69
0.15
IGJIGHA2P01591P01877adaptiveimmuneresponseantibacterialhumoralresponseglomerularfiltrationhumoralimmuneresponseimmuneresponseinnateimmuneresponsepositiveregulationofrespiratoryburstprotein-containingcomplexassemblyretinahomeostasisBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumphagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
DNA-directed RNA polymerase I subunit RPA1
539
DNA-directed RNA polymerase I subunit RPA2
1061
9.7
77
0.13
RPA1RPA2O95602Q9H9Y6negativeregulationofproteinlocalizationtonucleolusembryoimplantationneuralcrestformationnucleologenesisrRNAtranscription
Lutropin-choriogonadotropic hormone receptor
131
Choriogonadotropin subunit beta 3
113
9.8
80
0.13
LSHRCGB3P22888P0DN86activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayarachidonicacidsecretioncellularresponsetogonadotropinstimuluscellularresponsetoluteinizinghormonestimuluscentralnervoussystemdevelopmentcognitiondevelopmentofsecondarymalesexualcharacteristicsGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerhormone-mediatedsignalingpathwayluteinizinghormonesignalingpathwaymalegenitaliadevelopmentmalegonaddevelopmentovarianfollicledevelopmentovulationcycleprocessphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcalciumiontransportintocytosolpositiveregulationofcalcium-mediatedsignalingpositiveregulationofhormonebiosyntheticprocesspositiveregulationofinositoltrisphosphatebiosyntheticprocesspositiveregulationofreleaseofsequesteredcalciumionintocytosolproteintargetingtolysosomeregulationofsteroidhormonebiosyntheticprocessresponsetoxenobioticstimulusseminiferoustubuledevelopmentspermatogenesisuterusdevelopmentapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
Major prion protein
178
Major prion protein
178
9.8
67
0.15
PRIOPRIOP04925P04925activationofproteinkinaseactivitycalcium-mediatedsignalingusingintracellularcalciumsourcecellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocopperioncellularresponsetoxenobioticstimuluslearningormemorynegativeregulationofactivatedTcellproliferationnegativeregulationofamyloidprecursorproteincatabolicprocessnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofcalcineurin-NFATsignalingcascadenegativeregulationofcatalyticactivitynegativeregulationofdendriticspinemaintenancenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofinterferon-gammaproductionnegativeregulationofinterleukin-17productionnegativeregulationofinterleukin-2productionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofproteinphosphorylationnegativeregulationofTcellreceptorsignalingpathwayneuronprojectionmaintenancenucleobase-containingcompoundmetabolicprocesspositiveregulationofcelldeathpositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteintargetingtomembranepositiveregulationofproteintyrosinekinaseactivityproteindestabilizationproteinhomooligomerizationregulationofcalciumionimportacrossplasmamembraneregulationofglutamatereceptorsignalingpathwayregulationofintracellularcalciumactivatedchloridechannelactivityregulationofpeptidyl-tyrosinephosphorylationregulationofpotassiumiontransmembranetransportregulationofproteinlocalizationresponsetoamyloid-betaresponsetocadmiumionresponsetocopperionresponsetooxidativestress
DNA-directed RNA polymerase II subunit RPB3
236
DNA-directed RNA polymerases I, II, and III subunit RPABC5
45
9.8
87
0.12
I3LCH3A0A4X1VYD0I3LCH3A0A4X1VYD0transcriptionbyRNApolymeraseIItranscriptionDNA-templated
DNA-directed RNA polymerase I subunit RPA2
93
DNA-directed RNA polymerases I, II, and III subunit RPABC4
22
9.8
50
0.2
RPA2RPAB4Q9H9Y6P53803embryoimplantationneuralcrestformationnucleologenesisrRNAtranscriptionregulationoftranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseIII
Major prion protein
213
Major prion protein
213
9.8
85
0.12
PRIOPRIOP04925P04925activationofproteinkinaseactivitycalcium-mediatedsignalingusingintracellularcalciumsourcecellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocopperioncellularresponsetoxenobioticstimuluslearningormemorynegativeregulationofactivatedTcellproliferationnegativeregulationofamyloidprecursorproteincatabolicprocessnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofcalcineurin-NFATsignalingcascadenegativeregulationofcatalyticactivitynegativeregulationofdendriticspinemaintenancenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofinterferon-gammaproductionnegativeregulationofinterleukin-17productionnegativeregulationofinterleukin-2productionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofproteinphosphorylationnegativeregulationofTcellreceptorsignalingpathwayneuronprojectionmaintenancenucleobase-containingcompoundmetabolicprocesspositiveregulationofcelldeathpositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteintargetingtomembranepositiveregulationofproteintyrosinekinaseactivityproteindestabilizationproteinhomooligomerizationregulationofcalciumionimportacrossplasmamembraneregulationofglutamatereceptorsignalingpathwayregulationofintracellularcalciumactivatedchloridechannelactivityregulationofpeptidyl-tyrosinephosphorylationregulationofpotassiumiontransmembranetransportregulationofproteinlocalizationresponsetoamyloid-betaresponsetocadmiumionresponsetocopperionresponsetooxidativestress
Guanine nucleotide-binding protein G(i) subunit alpha-1
214
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
204
9.8
65
0.16
GNAI1GBB1P63096P62871adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormoneadenylatecyclase-activatingdopaminereceptorsignalingpathwaycellularresponsetocatecholaminestimuluscellularresponsetoprostaglandinEstimulus
Transcription initiation factor TFIID subunit 5
577
Transcription initiation factor TFIID subunit 9
121
9.8
75
0.14
TAF5TAF9Q15542Q16594DNA-templatedtranscriptioninitiationhistoneH3acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationmRNAtranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationfromRNApolymeraseIIpromoterpositiveregulationoftranscriptionDNA-templatedproteinphosphorylationregulationofDNArepairregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblytranscriptioninitiationfromRNApolymeraseIIpromoterboxC/DsnoRNPassemblycellularresponsetoDNAdamagestimulushistoneacetylationnegativeregulationofapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatornegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofresponsetocytokinestimuluspositiveregulationoftranscriptionbyRNApolymeraseIIproteinstabilizationregulationofRNAsplicingregulationoftranscriptionDNA-templatedresponsetointerleukin-1responsetoL-glutamate
Serine palmitoyltransferase 1
133
Serine palmitoyltransferase 2
511
9.8
99
0.1
SPTC1SPTC2O15269O15270ceramidebiosyntheticprocesspositiveregulationoflipophagyregulationoffatcellapoptoticprocesssphinganinebiosyntheticprocesssphingolipidbiosyntheticprocesssphingolipidmetabolicprocesssphingomyelinbiosyntheticprocesssphingosinebiosyntheticprocessadiposetissuedevelopment
Major prion protein
179
Major prion protein
179
9.8
60
0.17
PRIOPRIOP04273P04273activationofproteinkinaseactivitycalcium-mediatedsignalingusingintracellularcalciumsourcecellcyclecellularresponsetoamyloid-betacellularresponsetocopperioncellularresponsetoxenobioticstimuluslearningormemorynegativeregulationofactivatedTcellproliferationnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofcalcineurin-NFATsignalingcascadenegativeregulationofdendriticspinemaintenancenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofinterferon-gammaproductionnegativeregulationofinterleukin-17productionnegativeregulationofinterleukin-2productionnegativeregulationofproteinphosphorylationnegativeregulationofTcellreceptorsignalingpathwayneuronprojectionmaintenancepositiveregulationofneuronapoptoticprocesspositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteintargetingtomembranepositiveregulationofproteintyrosinekinaseactivityproteindestabilizationproteinhomooligomerizationregulationofcalciumionimportacrossplasmamembraneregulationofglutamatereceptorsignalingpathwayregulationofintracellularcalciumactivatedchloridechannelactivityregulationofpotassiumiontransmembranetransportresponsetooxidativestress
Cytochrome c
18
Cytochrome c1, heme protein, mitochondrial
124
9.6
69
0.15
CYCCY1P62894P00125apoptoticprocessmitochondrialelectrontransportcytochromectooxygenmitochondrialelectrontransportubiquinoltocytochromecpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocess
Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1
348
Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1
97
9.7
69
0.15
GRIK1GRIK1P22756-2P22756-2
STAGA complex 65 subunit gamma
173
Transcription initiation factor TFIID subunit 10
174
9.6
61
0.17
ST65GTAF10O94864Q12962histoneH3acetylationmaintenanceofproteinlocationinnucleusmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationpositiveregulationoftranscriptionDNA-templatedregulationofDNArepairregulationofRNAsplicingallantoisdevelopmentapoptoticprocessDNA-templatedtranscriptioninitiationembryonicplacentadevelopmentG1/StransitionofmitoticcellcyclehepatocytedifferentiationhistoneacetylationhistonedeubiquitinationlateralmesodermalcelldifferentiationlimbdevelopmentmRNAtranscriptionbyRNApolymeraseIImulticellularorganismgrowthpositiveregulationoftranscriptioninitiationfromRNApolymeraseIIpromoterproteinphosphorylationregulationofDNAbindingregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedRNApolymeraseIIpreinitiationcomplexassemblySAGAcomplexassemblysomitogenesistranscriptionbyRNApolymeraseIItranscriptioninitiationfromRNApolymeraseIIpromoter
C-C motif chemokine 15
77
C-C chemokine receptor type 1
24
9.7
66
0.16
CCL15CCR1Q16663P32246cell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitysignaltransductioncalciumiontransportcalcium-mediatedsignalingcelladhesioncellchemotaxiscellsurfacereceptorsignalingpathwaycytokine-mediatedsignalingpathwaydendriticcellchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerimmuneresponsenegativeregulationofbonemineralizationnegativeregulationofgeneexpressionpositiveregulationofcalciumiontransportpositiveregulationofcellmigrationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofmonocytechemotaxispositiveregulationofosteoclastdifferentiationresponsetowounding
Protein ADM2
110
Calcitonin gene-related peptide type 1 receptor
299
9.7
70
0.15
ADM2CALRLQ7Z4H4Q16602adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayangiogenesisdigestionfeedingbehaviornegativeregulationofbloodpressurepositiveregulationofangiogenesispositiveregulationofgeneexpressionpositiveregulationofheartrateproteinphosphorylationregulationofsystemicarterialbloodpressureadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwayadrenomedullinreceptorsignalingpathwaycalcitoningene-relatedpeptidereceptorsignalingpathwaycalciumiontransportcellsurfacereceptorsignalingpathwaycellularresponsetosucrosestimulusGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerheartdevelopmentnegativeregulationofinflammatoryresponsenegativeregulationofsmoothmusclecontractionpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteintransportreceptorinternalizationvascularassociatedsmoothmusclecellproliferation
Apoptotic protease-activating factor 1
115
Apoptotic protease-activating factor 1
258
9.6
70
0.15
APAFAPAFO14727O14727activationofcysteine-typeendopeptidaseactivityactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessbycytochromecagingapoptoticprocesscardiacmusclecellapoptoticprocesscelldifferentiationcellularresponsetotransforminggrowthfactorbetastimulusforebraindevelopmentintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstresskidneydevelopmentnervoussystemdevelopmentneuraltubeclosureneuronapoptoticprocesspositiveregulationofapoptoticprocesspositiveregulationofapoptoticsignalingpathwayregulationofapoptoticDNAfragmentationregulationofapoptoticprocessresponsetoG1DNAdamagecheckpointsignalingresponsetohypoxiaresponsetonutrient
Exosome complex component RRP46
138
Exosome complex component RRP40
83
9.8
98
0.1
EXOS5EXOS3Q9NQT4Q9NQT5defenseresponsetovirusDNAdeaminationexonucleolyticcatabolismofdeadenylatedmRNAnuclearmRNAsurveillance"nuclear-transcribedmRNAcatabolicprocessexonucleolytic3-5""polyadenylation-dependentsnoRNA3-endprocessing"RNAcatabolicprocessRNAprocessingrRNAcatabolicprocessrRNAprocessing"U4snRNA3-endprocessing"CUTcatabolicprocess"exonucleolytictrimmingtogeneratemature3-endof5.8SrRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)"isotypeswitchingnuclearpolyadenylation-dependentrRNAcatabolicprocessnuclearpolyadenylation-dependenttRNAcatabolicprocesspositiveregulationofisotypeswitching
Glycoprotein hormones alpha chain
55
Choriogonadotropin subunit beta 3
77
9.5
84
0.13
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
Insulin
100
Insulin
31
9.8
65
0.16
INSINSP01308P01318activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealingcellularresponsetopalmitoleicacidresponsetoL-arginine
Inosine-5'-monophosphate dehydrogenase 2
26
Inosine-5'-monophosphate dehydrogenase 2
26
9.5
45
0.23
IMDH2IMDH2P12268P12268"denovoXMPbiosyntheticprocess"cellularresponsetointerleukin-4circadianrhythmGMPbiosyntheticprocessGTPbiosyntheticprocesslymphocyteproliferationretinadevelopmentincamera-typeeye
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
382
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
75
9.8
84
0.12
NDUV1NDUS1Q91YT0Q91VD9aerobicrespirationmitochondrialATPsynthesiscoupledelectrontransportmitochondrialelectrontransportNADHtoubiquinoneprotonmotiveforce-drivenmitochondrialATPsynthesisapoptoticmitochondrialchangesATPmetabolicprocesscellularrespirationmitochondrialrespiratorychaincomplexIassemblyreactiveoxygenspeciesmetabolicprocessregulationofmitochondrialmembranepotential
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
95
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
138
9.5
88
0.12
ISCUISCUQ9H1K1Q9H1K1cellularironionhomeostasisiron-sulfurclusterassemblynegativeregulationofironionimportacrossplasmamembranepositiveregulationofaconitatehydrataseactivitypositiveregulationofmitochondrialelectrontransportNADHtoubiquinone
DNA-directed RNA polymerase subunit
1402
DNA-directed RNA polymerase subunit beta
1232
9.8
75
0.14
I3LJR4I3LGP4I3LJR4I3LGP4transcriptionbyRNApolymeraseII
DNA-directed RNA polymerase II subunit RPB1
1430
DNA-directed RNA polymerase II subunit RPB2
1155
9.8
82
0.12
RPB1RPB2P24928P30876DNA-templatedtranscriptionterminationpositiveregulationofRNAsplicingregulationoftranscriptionDNA-templatedtranscriptionbyRNApolymeraseII
Neuronal acetylcholine receptor subunit alpha-4
271
Neuronal acetylcholine receptor subunit alpha-4
271
9.8
63
0.16
ACHA4ACHA4P43681P43681actionpotentialBcellactivationbehavioralresponsetonicotinecalciumiontransportchemicalsynaptictransmissioncognitionDNArepairinhibitorypostsynapticpotentialiontransmembranetransportiontransportmembranedepolarizationnervoussystemprocessregulationofdopaminesecretionregulationofmembranepotentialresponsetohypoxiaresponsetonicotineresponsetooxidativestresssensoryperceptionofpainsignaltransductionsynaptictransmissioncholinergic
Glycoprotein hormones alpha chain
83
Thyrotropin subunit beta
72
9.8
86
0.12
GLHATSHBP01215P01222follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationanatomicalstructuremorphogenesiscell-cellsignalingresponsetocalciumionresponsetoestrogenresponsetovitaminA
DNA-directed RNA polymerase III subunit RPC3
439
DNA-directed RNA polymerase III subunit RPC6
287
9.8
84
0.12
RPC3RPC6Q9BUI4Q9H1D9defenseresponsetovirusinnateimmuneresponsepositiveregulationofinnateimmuneresponsepositiveregulationofinterferon-betaproductionregulationoftranscriptionbyRNApolymeraseIIItranscriptionDNA-templatedtranscriptionbyRNApolymeraseIII
C-C motif chemokine 20
33
C-C chemokine receptor type 6
288
9.8
64
0.16
CCL20CCR6P78556P51684antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecalcium-mediatedsignalingusingintracellularcalciumsourcecellchemotaxiscell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisdefenseresponsetobacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofTcellmigrationsignaltransductionTcellmigrationthymocytemigrationcalcium-mediatedsignalingcellulardefenseresponsedendriticcellchemotaxisDN2thymocytedifferentiationDN3thymocytedifferentiationhumoralimmuneresponseisotypeswitchingtoIgAisotypesleukocytemigrationinvolvedininflammatoryresponselymphocytemigrationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofdendriticcellchemotaxispositiveregulationofflagellatedspermmotilityinvolvedincapacitationregulationofTcellmigration
DNA-directed RNA polymerase II subunit RPB3
236
DNA-directed RNA polymerases I, II, and III subunit RPABC5
7
9.8
92
0.11
I3LCH3A0A4X1VYD0I3LCH3A0A4X1VYD0transcriptionbyRNApolymeraseIItranscriptionDNA-templated
Inosine-5'-monophosphate dehydrogenase 2
339
Inosine-5'-monophosphate dehydrogenase 2
468
9.8
96
0.11
IMDH2IMDH2P12268P12268"denovoXMPbiosyntheticprocess"cellularresponsetointerleukin-4circadianrhythmGMPbiosyntheticprocessGTPbiosyntheticprocesslymphocyteproliferationretinadevelopmentincamera-typeeye
Major prion protein
214
Major prion protein
214
9.8
70
0.15
PRIOPRIOP04273P04273activationofproteinkinaseactivitycalcium-mediatedsignalingusingintracellularcalciumsourcecellcyclecellularresponsetoamyloid-betacellularresponsetocopperioncellularresponsetoxenobioticstimuluslearningormemorynegativeregulationofactivatedTcellproliferationnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofcalcineurin-NFATsignalingcascadenegativeregulationofdendriticspinemaintenancenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofinterferon-gammaproductionnegativeregulationofinterleukin-17productionnegativeregulationofinterleukin-2productionnegativeregulationofproteinphosphorylationnegativeregulationofTcellreceptorsignalingpathwayneuronprojectionmaintenancepositiveregulationofneuronapoptoticprocesspositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteintargetingtomembranepositiveregulationofproteintyrosinekinaseactivityproteindestabilizationproteinhomooligomerizationregulationofcalciumionimportacrossplasmamembraneregulationofglutamatereceptorsignalingpathwayregulationofintracellularcalciumactivatedchloridechannelactivityregulationofpotassiumiontransmembranetransportresponsetooxidativestress
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
135
9.8
93
0.11
F1RVN1A0A287BG40F1RVN1A0A287BG40mitochondrialelectrontransportNADHtoubiquinonecardiacmuscletissuedevelopmentnervoussystemdevelopment
Sodium channel protein type 7 subunit alpha
927
Sodium channel subunit beta-3
180
9.8
57
0.18
SCN7ASCN3BQ01118Q9NY72cellularhomeostasismembranedepolarizationduringactionpotentialmusclecontractionneuronalactionpotentialregulationofiontransmembranetransportresponsetobacteriumsodiumionhomeostasissodiumiontransmembranetransportsodiumiontransportatrialcardiacmusclecellactionpotentialcardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractionmembranedepolarizationmembranedepolarizationduringcardiacmusclecellactionpotentialnervoussystemdevelopmentpositiveregulationofheartratepositiveregulationofsodiumiontransportproteinlocalizationtoplasmamembraneregulationofatrialcardiacmusclecellmembranedepolarizationregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityregulationofventricularcardiacmusclecellmembranedepolarizationSAnodecellactionpotentialsensoryperceptionofpainventricularcardiacmusclecellactionpotential
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
5-hydroxytryptamine receptor 4
123
9.9
71
0.14
GNAI15HT4RP63096Q13639adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormoneadenylatecyclase-inhibitingserotoninreceptorsignalingpathwaychemicalsynaptictransmissionGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerregulationofappetite
Mucin-2
1082
Mucin-2
1088
9.9
80
0.13
A0A0G2JR65A0A0G2JR65A0A0G2JR65A0A0G2JR65
Origin recognition complex subunit 4
194
Origin recognition complex subunit 5
171
9.9
73
0.14
ORC4ORC5O43929O43913DNAreplicationinitiationDNAreplicationregulationofDNAreplication
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
116
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
128
9.9
88
0.11
NDUS8NDUS1P42028P15690aerobicrespirationmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyresponsetooxidativestressapoptoticmitochondrialchangesATPmetabolicprocesscellularrespirationreactiveoxygenspeciesmetabolicprocessregulationofmitochondrialmembranepotential
Glycoprotein hormones alpha chain
111
Choriogonadotropin subunit beta 3
110
10.0
75
0.13
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
Centromere protein T
486
Centromere protein W
47
9.9
62
0.16
CENPTCENPWQ96BT3Q5EE01celldivisionchromosomeorganizationchromosomesegregationkinetochoreassemblymitoticcellcycleCENP-Acontainingchromatinassembly
Insulin receptor
712
Insulin receptor
712
9.9
51
0.2
INSRINSRP06213P06213activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearancecarbohydratemetabolicprocesscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaylearningmalegonaddevelopmentmalesexdeterminationmemoryneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationoftranscriptionDNA-templatedtransmembranereceptorproteintyrosinekinasesignalingpathwaytransportacrossblood-brainbarrierviralentryintohostcell
Cysteine desulfurase, mitochondrial
308
Frataxin, mitochondrial
50
10.0
83
0.12
NFS1FRDAQ9Y697Q165952Fe-2Sclusterassemblyironincorporationintometallo-sulfurclusteriron-sulfurclusterassemblyMo-molybdopterincofactorbiosyntheticprocessadultwalkingbehaviorcellularironionhomeostasiscellularresponsetohydrogenperoxideembryodevelopmentendinginbirthoregghatchinghemebiosyntheticprocessiontransportmitochondrionorganizationmusclecellcellularhomeostasisnegativeregulationofapoptoticprocessnegativeregulationofmulticellularorganismgrowthnegativeregulationoforgangrowthnegativeregulationofreleaseofcytochromecfrommitochondriaorgangrowthoxidativephosphorylationpositiveregulationofaconitatehydrataseactivitypositiveregulationofcatalyticactivitypositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationoflyaseactivitypositiveregulationofsuccinatedehydrogenaseactivityproprioceptionproteinautoprocessingregulationofferrochelataseactivityresponsetoironion
Mediator of RNA polymerase II transcription subunit 1
464
Mediator of RNA polymerase II transcription subunit 24
93
10.0
70
0.14
MED1MED24Q15648O75448androgenbiosyntheticprocessangiogenesisanimalorganregenerationbraindevelopmentcellmorphogenesiscellularresponsetoepidermalgrowthfactorstimuluscellularresponsetohepatocytegrowthfactorstimuluscellularresponsetosteroidhormonestimuluscellularresponsetothyroidhormonestimulusembryonichearttubedevelopmentembryonichemopoiesisembryonichindlimbmorphogenesisembryonicplacentadevelopmentenucleateerythrocytedevelopmentepithelialcellproliferationinvolvedinmammaryglandductelongationerythrocytedevelopmentfatcelldifferentiationG0toG1transitionhematopoieticstemcelldifferentiationintracellularsteroidhormonereceptorsignalingpathwaykeratinocytedifferentiationlactationlensdevelopmentincamera-typeeyeliverdevelopmentmammaryglandbranchinginvolvedinpregnancymammaryglandbranchinginvolvedinthelarchemegakaryocytedevelopmentmonocytedifferentiationmRNAtranscriptionbyRNApolymeraseIInegativeregulationofapoptoticprocessnegativeregulationofkeratinocyteproliferationnegativeregulationofneurondifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIperoxisomeproliferatoractivatedreceptorsignalingpathwaypositiveregulationoferythrocytedifferentiationpositiveregulationofG0toG1transitionpositiveregulationofgeneexpressionpositiveregulationofhepatocyteproliferationpositiveregulationofinterferon-gamma-mediatedsignalingpathwaypositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofkeratinocytedifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterpositiveregulationoftranscriptioninitiationfromRNApolymeraseIIpromoterpositiveregulationoftranscriptionDNA-templatedproteinimportintonucleusregulationofRNAbiosyntheticprocessregulationoftranscriptionbyRNApolymeraseIIregulationofvitaminDreceptorsignalingpathwayretinalpigmentepitheliumdevelopmentRNApolymeraseIIpreinitiationcomplexassemblythyroidhormonegenerationthyroidhormonemediatedsignalingpathwayventriculartrabeculamyocardiummorphogenesis
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
25
Guanine nucleotide-binding protein G(T) subunit gamma-T1
37
10.0
55
0.18
GBB1GBG1P62871P02698adenylatecyclase-activatingdopaminereceptorsignalingpathwaycellularresponsetocatecholaminestimuluscellularresponsetoprostaglandinEstimulusGprotein-coupledreceptorsignalingpathway
Glial cell line-derived neurotrophic factor
178
Glial cell line-derived neurotrophic factor
179
9.9
62
0.16
GDNFGDNFP39905P39905adultlocomotorybehaviorbranchinginvolvedinuretericbudmorphogenesiscommissuralneuronaxonguidancedorsalspinalcorddevelopmentembryonicorgandevelopmententericnervoussystemdevelopmentmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesismetanephrosdevelopmentmRNAstabilizationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofneuronapoptoticprocessnervoussystemdevelopmentneuralcrestcellmigrationneuronprojectiondevelopmentorganinductionperipheralnervoussystemdevelopmentperistalsispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofdopaminesecretionpositiveregulationofmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesispositiveregulationofmonooxygenaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofuretericbudformationpostganglionicparasympatheticfiberdevelopmentpostsynapticmembraneorganizationregulationofdopamineuptakeinvolvedinsynaptictransmissionregulationofgeneexpressionregulationofmorphogenesisofabranchingstructureregulationofsemaphorin-plexinsignalingpathwayregulationofstemcelldifferentiationsignaltransductionsympatheticnervoussystemdevelopmenturetericbudformation
Glutamate receptor
549
Protein cornichon homolog 2
84
9.9
60
0.17
C9K0Z0CNIH2C9K0Z0O35089localizationwithinmembranenegativeregulationofanterogradesynapticvesicletransportnegativeregulationofreceptorlocalizationtosynapseregulationofAMPAreceptoractivityregulationofmembranepotentialregulationofNMDAreceptoractivityregulationofpostsynapticneurotransmitterreceptoractivitysynaptictransmissionglutamatergicvesicle-mediatedtransport
Glycoprotein hormones alpha chain
108
Choriogonadotropin subunit beta 3
58
10.0
73
0.14
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
Insulin receptor
551
Insulin receptor
709
9.5
47
0.22
INSRINSRP06213P06213activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearancecarbohydratemetabolicprocesscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaylearningmalegonaddevelopmentmalesexdeterminationmemoryneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationoftranscriptionDNA-templatedtransmembranereceptorproteintyrosinekinasesignalingpathwaytransportacrossblood-brainbarrierviralentryintohostcell
39S ribosomal protein L37, mitochondrial
203
39S ribosomal protein S30, mitochondrial
149
9.8
78
0.13
RM37RT30Q9BZE1Q9NP92mitochondrialtranslationtranslationapoptoticprocess
Glycoprotein hormones alpha chain
111
Thyrotropin subunit beta
115
9.5
77
0.14
GLHATSHBP01215P01222follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationanatomicalstructuremorphogenesiscell-cellsignalingresponsetocalciumionresponsetoestrogenresponsetovitaminA
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
140
9.8
86
0.12
NDUV1NDUV2P49821P19404aerobicrespirationmitochondrialATPsynthesiscoupledelectrontransportmitochondrialelectrontransportNADHtoubiquinoneprotonmotiveforce-drivenmitochondrialATPsynthesiscardiacmuscletissuedevelopmentnervoussystemdevelopment
Glutamate receptor 1
603
Glutamate receptor 1
603
9.8
82
0.12
GRIA1GRIA1P19490P19490cellularresponsetoaminestimuluscellularresponsetoaminoacidstimuluscellularresponsetoammoniumioncellularresponsetodsRNAcellularresponsetogrowthfactorstimuluscellularresponsetoorganiccycliccompoundcellularresponsetopeptidehormonestimuluschemicalsynaptictransmissionlong-termmemorylong-termsynapticdepressionmodulationofchemicalsynaptictransmissionneuronalactionpotentialpositiveregulationofmembranepotentialpositiveregulationofsynaptictransmissionreceptorinternalizationregulationofpostsynapticmembranepotentialregulationofreceptorrecyclingregulationofsynapticplasticityresponsetoarsenic-containingsubstanceresponsetococaineresponsetoelectricalstimulusresponsetoestradiolresponsetofungicideresponsetolithiumionresponsetoorganiccycliccompoundresponsetopeptidehormoneresponsetotoxicsubstanceresponsetoxenobioticstimulusspinalcorddevelopmentsynaptictransmissionglutamatergic
Insulin-like growth factor-binding protein 3
40
Insulin-like growth factor I
66
9.9
60
0.17
IBP3IGF1P17936P05019apoptoticprocessMAPKcascadenegativeregulationofcellpopulationproliferationnegativeregulationofproteinphosphorylationnegativeregulationofsignaltransductionnegativeregulationofsmoothmusclecellmigrationnegativeregulationofsmoothmusclecellproliferationosteoblastdifferentiationpositiveregulationofapoptoticprocesspositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmyoblastdifferentiationproteinphosphorylationregulationofcellgrowthregulationofglucosemetabolicprocessregulationofinsulin-likegrowthfactorreceptorsignalingpathwaytypeBpancreaticcellproliferationactivationofproteinkinaseBactivitybonemineralizationinvolvedinbonematurationcellactivationcellpopulationproliferationcellularresponsetoamyloid-betaERK1andERK2cascadeglycolatemetabolicprocessinsulin-likegrowthfactorreceptorsignalingpathwaymusclehypertrophymuscleorgandevelopmentmyoblastdifferentiationmyoblastproliferationmyotubecelldevelopmentnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofinterleukin-1betaproductionnegativeregulationofneuroinflammatoryresponsenegativeregulationofoocytedevelopmentnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftumornecrosisfactorproductionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcardiacmusclehypertrophypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRasproteinsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftrophectodermalcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseBsignalingproteinstabilizationproteoglycanbiosyntheticprocessRasproteinsignaltransductionregulationofgeneexpressionregulationofmulticellularorganismgrowthregulationofproteinphosphorylationresponsetoheatsignaltransductionskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationskeletalsystemdevelopmentwoundhealing
RNA polymerase-associated protein CTR9 homolog
511
WD repeat-containing protein 61
266
9.9
57
0.18
CTR9WDR61Q6PD62Q9GZS3blastocystgrowthblastocysthatchingcellularresponsetolipopolysaccharideendodermalcellfatecommitmenthistoneH2BubiquitinationhistoneH3-K4trimethylationhistonemonoubiquitinationinnercellmasscelldifferentiationinterleukin-6-mediatedsignalingpathwaynegativeregulationofmyeloidcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofhistoneH3-K4methylationpositiveregulationofhistoneH3-K79methylationreceptorsignalingpathwayviaJAK-STATregulationofgeneticimprintingregulationofhistoneH3-K4methylationregulationoftranscriptionDNA-templatedstemcellpopulationmaintenancetranscriptionelongationfromRNApolymeraseIIpromotertrophectodermalcelldifferentiationWntsignalingpathwayhistoneH3-K4methylation
DNA repair protein XRCC4
165
DNA ligase 4
901
9.9
57
0.18
XRCC4DNLI4Q13426P49917DNAligationinvolvedinDNArepairdouble-strandbreakrepairdouble-strandbreakrepairvianonhomologousendjoiningimmunoglobulinV(D)Jrecombinationpositiveregulationofligaseactivitypositiveregulationofphosphatidylserineexposureonapoptoticcellsurfaceproteinlocalizationtositeofdouble-strandbreakresponsetoX-raycellcyclecelldivisioncellpopulationproliferationcellularresponsetoionizingradiationcellularresponsetolithiumioncentralnervoussystemdevelopmentchromosomeorganizationDN2thymocytedifferentiationDNAbiosyntheticprocessDNAligationDNAligationinvolvedinDNArecombinationDNAreplicationdouble-strandbreakrepairviaclassicalnonhomologousendjoiningestablishmentofintegratedprovirallatencyfibroblastproliferationinuteroembryonicdevelopmentisotypeswitchingnegativeregulationofneuronapoptoticprocessneurogenesisneuronapoptoticprocessnucleotide-excisionrepairDNAgapfillingpositiveregulationofchromosomeorganizationpositiveregulationoffibroblastproliferationpositiveregulationofneurogenesispro-BcelldifferentiationresponsetogammaradiationsinglestrandbreakrepairsomaticstemcellpopulationmaintenancestemcellproliferationTcelldifferentiationinthymusTcellreceptorV(D)JrecombinationV(D)Jrecombination
DNA-directed RNA polymerase subunit
1430
DNA-directed RNA polymerase subunit beta
1232
9.5
71
0.15
A0A480TA59A0A4X1TVZ5A0A480TA59A0A4X1TVZ5transcriptionbyRNApolymeraseIItranscriptionDNA-templated
Splicing factor 3B subunit 1
677
PHD finger-like domain-containing protein 5A
85
9.9
69
0.15
SF3B1PHF5AO75533Q7RTV0chromatinremodelingmRNAsplicingviaspliceosomepositiveregulationofhistoneacetylationpositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIRNAsplicingRNAsplicingviatransesterificationreactionsspliceosomalcomplexassemblyU2-typeprespliceosomeassemblypositiveregulationoftranscriptionDNA-templatedstemcelldifferentiation
Immunoglobulin heavy constant alpha 1
182
Immunoglobulin heavy constant alpha 1
182
9.9
43
0.23
IGHA1IGHA1P01876P01876adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
Clathrin heavy chain
1565
Clathrin light chain
178
10.0
72
0.14
C0MHR2F1S398C0MHR2F1S398clathrincoatassemblyintracellularproteintransportmitoticcellcyclereceptor-mediatedendocytosisclathrin-dependentendocytosis
Mediator of RNA polymerase II transcription subunit 4
162
Mediator of RNA polymerase II transcription subunit 26
598
9.9
75
0.13
MED4MED26Q9NPJ6O95402positiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterpositiveregulationoftranscriptioninitiationfromRNApolymeraseIIpromoterpositiveregulationoftranscriptionDNA-templatedregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblytranscriptionbyRNApolymeraseIIpositiveregulationofgeneexpressiontranscriptioninitiationfromRNApolymeraseIIpromoter
Interleukin-25
115
Interleukin-25
115
9.9
83
0.12
IL25IL25Q9H293Q9H293eosinophildifferentiationinflammatoryresponsetoantigenicstimuluspositiveregulationoftranscriptionbyRNApolymeraseIIresponsetofungusresponsetonematode
Glycoprotein hormones alpha chain
111
Thyrotropin subunit beta
72
9.9
81
0.12
GLHATSHBP01215P01222follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationanatomicalstructuremorphogenesiscell-cellsignalingresponsetocalciumionresponsetoestrogenresponsetovitaminA
Glutamate receptor
99
Glutamate receptor
99
9.6
62
0.17
G3V9I2G3V9I2G3V9I2G3V9I2
Atypical chemokine receptor 3
34
Stromal cell-derived factor 1
55
9.0
67
0.17
ACKR3SDF1P25106P48061angiogenesiscalcium-mediatedsignalingcelladhesioncellchemotaxischemokine-mediatedsignalingpathwayimmuneresponsenegativeregulationofcellpopulationproliferationnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageoculomotornervedevelopmentpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofmesenchymalstemcellmigrationreceptorinternalizationvasculogenesisadultlocomotorybehavioranimalorganregenerationantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideaxonguidancebloodcirculationcellularcalciumionhomeostasiscellularresponsetochemokinechemokine(C-X-Cmotif)ligand12signalingpathwaychemotaxisdefenseresponsedetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainGprotein-coupledreceptorsignalingpathwayinductionofpositivechemotaxisintegrinactivationkillingofcellsofanotherorganismnegativeregulationofdendriticcellapoptoticprocessnegativeregulationofleukocytetetheringorrollingneuronmigrationpositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofcalciumionimportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofdopaminesecretionpositiveregulationofendothelialcellproliferationpositiveregulationofmonocytechemotaxispositiveregulationofneurondifferentiationpositiveregulationofTcellmigrationregulationofactinpolymerizationordepolymerizationresponsetoheatresponsetohypoxiaresponsetopeptidehormoneresponsetoradiationresponsetoultrasoundresponsetovirussignaltransductionTcellchemotaxistelencephaloncellmigration
COP9 signalosome complex subunit 4
378
COP9 signalosome complex subunit 7b
181
9.0
82
0.14
CSN4CSN7BQ9BT78Q9H9Q2proteindeneddylationproteinneddylationregulationofproteinneddylationCOP9signalosomeassembly
Broad substrate specificity ATP-binding cassette transporter ABCG2
438
Broad substrate specificity ATP-binding cassette transporter ABCG2
438
9.7
100
0.1
ABCG2ABCG2Q9UNQ0Q9UNQ0biotintransportcellulardetoxificationexportacrossplasmamembranelipidtransportorganicaniontransportrenaluratesaltexcretionriboflavintransporttransepithelialtransporttransmembranetransporttransportacrossblood-brainbarrieruratemetabolicprocessxenobiotictransportacrossblood-brainbarrier
Glycoprotein hormones alpha chain
55
Choriogonadotropin subunit beta 3
110
9.7
69
0.15
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
DNA excision repair protein ERCC-8
178
DNA excision repair protein ERCC-6
730
9.6
78
0.13
ERCC8ERCC6Q13216Q03468cellularresponsetoDNAdamagestimulusdouble-strandbreakrepairviaclassicalnonhomologousendjoiningpositiveregulationofDNArepairproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautoubiquitinationproteinpolyubiquitinationregulationoftranscription-couplednucleotide-excisionrepairresponsetooxidativestressresponsetoUVresponsetoX-raysinglestrandbreakrepairtranscription-couplednucleotide-excisionrepairbase-excisionrepairchromatinremodelingDNAdamagecheckpointsignalingDNAprotectionDNArepairintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageJNKcascademulticellularorganismgrowthnegativeregulationofdouble-strandbreakrepairvianonhomologousendjoiningneurogenesisneurondifferentiationneuronprojectiondevelopmentphotoreceptorcellmaintenancepositiveregulationofDNA-templatedtranscriptionelongationpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofhistoneacetylationpositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIpositiveregulationoftranscriptioninitiationfromRNApolymeraseIIpromoterpyrimidinedimerrepairregulationofDNA-templatedtranscriptionelongationregulationoftranscriptionelongationfromRNApolymeraseIIpromoterresponsetogammaradiationresponsetosuperoxideresponsetotoxicsubstanceresponsetoUV-BtranscriptionbyRNApolymeraseIItranscriptionelongationfromRNApolymeraseIpromoter
Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1
97
Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1
97
9.0
72
0.15
GRIK1GRIK1P22756-2P22756-2
Glycoprotein hormones alpha chain
83
Choriogonadotropin subunit beta 3
120
9.7
83
0.12
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
Glycoprotein hormones alpha chain
111
Choriogonadotropin subunit beta 3
58
9.1
81
0.14
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
COP9 signalosome complex subunit 5
308
COP9 signalosome complex subunit 6
299
9.7
79
0.13
CSN5CSN6Q92905Q7L5N1exosomalsecretionnegativeregulationofapoptoticprocesspositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoftranscriptionbyRNApolymeraseIIpost-translationalproteinmodificationproteindeneddylationproteindeubiquitinationproteinneddylationregulationofcellcycleregulationofIRE1-mediatedunfoldedproteinresponseregulationofJNKcascaderegulationofproteinneddylationtranslation
Beta-2-microglobulin
100
Beta-2-microglobulin
100
9.7
64
0.16
B2MGB2MGP61769P61769amyloidfibrilformationantibacterialhumoralresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofexogenousproteinantigenviaMHCclassIbTAP-dependentantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetoironioncellularresponsetoiron(III)ioncellularresponsetolipopolysaccharidecellularresponsetonicotinedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseironionhomeostasisironiontransportlearningormemorynegativeregulationofepithelialcellproliferationnegativeregulationofforebrainneurondifferentiationnegativeregulationofneurogenesisnegativeregulationofneuronprojectiondevelopmentnegativeregulationofreceptorbindingpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofcellularsenescencepositiveregulationofferrousironbindingpositiveregulationofproteinbindingpositiveregulationofreceptorbindingpositiveregulationofreceptor-mediatedendocytosispositiveregulationofTcellactivationpositiveregulationofTcellcytokineproductionpositiveregulationofTcellmediatedcytotoxicitypositiveregulationoftransferrinreceptorbindingproteinhomotetramerizationproteinrefoldingregulationoferythrocytedifferentiationregulationofironiontransportregulationofmembranedepolarizationresponsetomoleculeofbacterialoriginretinahomeostasissensoryperceptionofsmellTcelldifferentiationinthymusTcellmediatedcytotoxicity
Splicing factor 3B subunit 1
677
PHD finger-like domain-containing protein 5A
46
9.0
64
0.17
SF3B1PHF5AO75533Q7RTV0chromatinremodelingmRNAsplicingviaspliceosomepositiveregulationofhistoneacetylationpositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIRNAsplicingRNAsplicingviatransesterificationreactionsspliceosomalcomplexassemblyU2-typeprespliceosomeassemblypositiveregulationoftranscriptionDNA-templatedstemcelldifferentiation
TMEM106B protein
254
TMEM106B protein
254
9.7
56
0.18
Q8N353Q8N353Q8N353Q8N353
Glycoprotein hormones alpha chain
55
Choriogonadotropin subunit beta 3
29
9.0
75
0.15
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
382
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
64
9.7
87
0.12
NDUV1NDUS1P25708P15690mitochondrialelectrontransportNADHtoubiquinoneapoptoticmitochondrialchangesATPmetabolicprocesscellularrespirationmitochondrialrespiratorychaincomplexIassemblyreactiveoxygenspeciesmetabolicprocessregulationofmitochondrialmembranepotential
DNA-directed RNA polymerase I subunit RPA2
93
DNA-directed RNA polymerases I, II, and III subunit RPABC4
19
9.6
61
0.17
RPA2RPAB4Q9H9Y6P53803embryoimplantationneuralcrestformationnucleologenesisrRNAtranscriptionregulationoftranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseIII
Actin-related protein 2/3 complex subunit 1B
265
Actin-related protein 2/3 complex subunit 4
21
9.6
86
0.12
ARC1BARPC4O15143P59998Arp2/3complex-mediatedactinnucleationregulationofactinfilamentpolymerizationresponsetoestradiolresponsetoestrogenactinfilamentpolymerizationactinnucleation
Insulin receptor
674
Isoform Short of Insulin receptor
899
9.0
66
0.17
INSRINSRP06213P06213-2activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearancecarbohydratemetabolicprocesscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaylearningmalegonaddevelopmentmalesexdeterminationmemoryneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationoftranscriptionDNA-templatedtransmembranereceptorproteintyrosinekinasesignalingpathwaytransportacrossblood-brainbarrierviralentryintohostcell
DNA-directed RNA polymerase III subunit RPC2
924
DNA-directed RNA polymerases I, II, and III subunit RPABC5
45
9.7
92
0.11
RPC2RPAB5Q9NW08P62875defenseresponsetovirusinnateimmuneresponsepositiveregulationofinnateimmuneresponsepositiveregulationofinterferon-betaproductiontranscriptionDNA-templatedregulationoftranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseIItRNAtranscriptionbyRNApolymeraseIII
Sodium channel subunit beta-4
58
Sodium channel protein type 1 subunit alpha
921
9.0
49
0.23
SCN4BSCN1AQ8IWT1P35498AVnodecellactionpotentialcardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractionestablishmentoflocalizationincellmembranedepolarizationduringcardiacmusclecellactionpotentialpositiveregulationofsodiumiontransportregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityregulationofventricularcardiacmusclecellmembranerepolarizationsodiumiontransmembranetransportsodiumiontransportadultwalkingbehaviordetectionofmechanicalstimulusinvolvedinsensoryperceptionofpainmembranedepolarizationduringactionpotentialneuromuscularprocesscontrollingpostureneuronalactionpotentialneuronalactionpotentialpropagationregulationofiontransmembranetransport
DNA-directed RNA polymerase II subunit RPB3
236
DNA-directed RNA polymerases I, II, and III subunit RPABC5
7
9.0
86
0.13
RPB3RPAB5P19387P62875transcriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseItRNAtranscriptionbyRNApolymeraseIII
General transcription factor IIH subunit 3
142
General transcription factor IIH subunit 2
381
9.0
78
0.14
TF2H3TF2H2Q13889Q13888DNArepairnucleotide-excisionrepairphosphorylationofRNApolymeraseIIC-terminaldomaintranscriptionbyRNApolymeraseIIGprotein-coupledreceptorinternalizationpositiveregulationofDNAhelicaseactivityregulationoftranscriptionbyRNApolymeraseIIresponsetoUVtranscriptioninitiationfromRNApolymeraseIIpromoter
C-C motif chemokine 15
77
C-C chemokine receptor type 1
273
9.6
70
0.15
CCL15CCR1Q16663P32246cell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitysignaltransductioncalciumiontransportcalcium-mediatedsignalingcelladhesioncellchemotaxiscellsurfacereceptorsignalingpathwaycytokine-mediatedsignalingpathwaydendriticcellchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerimmuneresponsenegativeregulationofbonemineralizationnegativeregulationofgeneexpressionpositiveregulationofcalciumiontransportpositiveregulationofcellmigrationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofmonocytechemotaxispositiveregulationofosteoclastdifferentiationresponsetowounding
DNA-directed RNA polymerase III subunit RPC1
72
DNA-directed RNA polymerase III subunit RPC2
1092
9.0
68
0.16
RPC1RPC2O14802Q9NW08defenseresponsetovirusinnateimmuneresponsepositiveregulationofinterferon-betaproductiontranscriptionDNA-templatedpositiveregulationofinnateimmuneresponse
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
176
9.1
84
0.13
NDUV1NDUV2P49821P19404aerobicrespirationmitochondrialATPsynthesiscoupledelectrontransportmitochondrialelectrontransportNADHtoubiquinoneprotonmotiveforce-drivenmitochondrialATPsynthesiscardiacmuscletissuedevelopmentnervoussystemdevelopment
Rapamycin-insensitive companion of mTOR
192
Target of rapamycin complex 2 subunit MAPKAP1
27
9.6
80
0.13
RICTRSIN1Q6R327Q9BPZ7actincytoskeletonreorganizationcellularresponsetonutrientlevelscytoskeletonorganizationembryodevelopmentendinginbirthoregghatchingnegativeregulationofapoptoticprocesspeptidyl-serinephosphorylationphosphorylationpositiveregulationofactinfilamentpolymerizationpositiveregulationofcellgrowthpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofTORsignalingregulationofactincytoskeletonorganizationregulationofestablishmentofcellpolarityregulationofgeneexpressionregulationofGTPaseactivityregulationofinflammatoryresponseregulationofpeptidyl-serinephosphorylationregulationofproteinkinaseBsignalingTORC2signalingnegativeregulationofRasproteinsignaltransductionpositiveregulationofpeptidyl-serinephosphorylationregulationofcellularresponsetooxidativestresssubstantianigradevelopment
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
134
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
9.6
90
0.12
NDUV2NDUV1Q9D6J6Q91YT0aerobicrespirationcardiacmuscletissuedevelopmentmitochondrialelectrontransportNADHtoubiquinonenervoussystemdevelopmentprotonmotiveforce-drivenmitochondrialATPsynthesismitochondrialATPsynthesiscoupledelectrontransport
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
130
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
138
9.6
79
0.13
ISCUISCUQ9H1K1Q9H1K1cellularironionhomeostasisiron-sulfurclusterassemblynegativeregulationofironionimportacrossplasmamembranepositiveregulationofaconitatehydrataseactivitypositiveregulationofmitochondrialelectrontransportNADHtoubiquinone
Protein tweety homolog 2
101
Protein tweety homolog 2
100
9.6
73
0.14
TTYH2TTYH2Q9BSA4Q9BSA4
Cation-independent mannose-6-phosphate receptor
901
Insulin-like growth factor II
71
9.5
68
0.15
MPRIIGF2P08169P01344lysosomaltransportanimalorganmorphogenesisembryonicplacentadevelopmentembryonicplacentamorphogenesisexocrinepancreasdevelopmentglucosemetabolicprocessinuteroembryonicdevelopmentinsulinreceptorsignalingpathwayinsulinreceptorsignalingpathwayviaphosphatidylinositol3-kinasenegativeregulationofmusclecelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIosteoblastdifferentiationpositiveregulationofactivatedTcellproliferationpositiveregulationofcatalyticactivitypositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofglycogen(starch)synthaseactivitypositiveregulationofglycogenbiosyntheticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofmulticellularorganismgrowthpositiveregulationoforgangrowthpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofskeletalmuscletissuegrowthpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularendothelialcellproliferationregulationofgeneexpressionbygenomicimprintingregulationofhistonemodificationregulationofmusclecelldifferentiationregulationoftranscriptionDNA-templatedspongiotrophoblastcellproliferationstriatedmusclecelldifferentiation
COP9 signalosome complex subunit 6
266
COP9 signalosome complex subunit 7b
157
9.1
84
0.13
CSN6CSN7BQ7L5N1Q9H9Q2proteindeneddylationproteinneddylationregulationofproteinneddylationCOP9signalosomeassembly
Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
122
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
9.5
59
0.18
B1H241GNAI1B1H241P63096adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaybasementmembraneorganizationcellmigrationinvolvedingastrulationcell-celladhesioninvolvedingastrulationinuteroembryonicdevelopmentvasculaturedevelopmentvisuallearningadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormone
Proteasome subunit alpha type-1
156
26S proteasome regulatory subunit 6A
390
9.5
83
0.13
PSA1Q6P6U2P18420Q6P6U2immunesystemprocessnegativeregulationofinflammatoryresponsetoantigenicstimulusproteasomalproteincatabolicprocessubiquitin-dependentproteincatabolicprocessproteincatabolicprocess
Transcription activator BRG1
423
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
492
9.1
64
0.17
SMCA4SMRD1P51532Q96GM5chromatinremodelingnegativeregulationofandrogenreceptorsignalingpathwaynegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednervoussystemdevelopmentneuralretinadevelopmentnucleosomedisassemblypositiveregulationbyhostofviraltranscriptionpositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofdouble-strandbreakrepairpositiveregulationofglucosemediatedsignalingpathwaypositiveregulationofmiRNAtranscriptionpositiveregulationofmyoblastdifferentiationpositiveregulationofstemcellpopulationmaintenancepositiveregulationofTcelldifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionofnucleolarlargerRNAbyRNApolymeraseIpositiveregulationoftranscriptionDNA-templatedpositiveregulationofWntsignalingpathwayregulationofG0toG1transitionregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofnucleotide-excisionrepairregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIpreinitiationcomplexassemblycellularresponsetofattyacidepigeneticmaintenanceofchromatinintranscription-competentconformation
Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1
348
Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1
348
9.7
68
0.15
GRIK1GRIK1P22756-2P22756-2
Glycoprotein hormones alpha chain
111
Thyrotropin subunit beta
51
9.7
75
0.14
GLHATSHBP01215P01222follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationanatomicalstructuremorphogenesiscell-cellsignalingresponsetocalciumionresponsetoestrogenresponsetovitaminA
Glycoprotein hormones alpha chain
56
Choriogonadotropin subunit beta 3
58
9.1
82
0.13
GLHACGB3P01215P0DN86follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationapoptoticprocesscell-cellsignalingfemalegametegenerationsignaltransduction
Proteasome subunit alpha type-1
148
26S proteasome regulatory subunit 6A
390
9.1
88
0.12
PSA1Q6P6U2P18420Q6P6U2immunesystemprocessnegativeregulationofinflammatoryresponsetoantigenicstimulusproteasomalproteincatabolicprocessubiquitin-dependentproteincatabolicprocessproteincatabolicprocess
DNA-directed RNA polymerase I subunit RPA1
67
DNA-directed RNA polymerase I subunit RPA2
1070
9.5
67
0.16
RPA1RPA2O95602Q9H9Y6negativeregulationofproteinlocalizationtonucleolusembryoimplantationneuralcrestformationnucleologenesisrRNAtranscription
Glutamate receptor ionotropic, delta-1
96
Glutamate receptor ionotropic, delta-1
96
9.5
77
0.14
GRID1GRID1Q62640Q62640modulationofchemicalsynaptictransmissionsocialbehaviorsynaptictransmissionglutamatergic
Cytochrome b-c1 complex subunit 6, mitochondrial
67
Cytochrome c1, heme protein, mitochondrial
219
9.5
56
0.19
QCR6CY1P07919P08574aerobicrespirationcellularrespirationmitochondrialelectrontransportubiquinoltocytochromecoxidativephosphorylationresponsetoglucagon
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
179
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
7.0
88
0.16
NDUV2NDUV1Q9D6J6Q91YT0aerobicrespirationcardiacmuscletissuedevelopmentmitochondrialelectrontransportNADHtoubiquinonenervoussystemdevelopmentprotonmotiveforce-drivenmitochondrialATPsynthesismitochondrialATPsynthesiscoupledelectrontransport
Calcium homeostasis modulator protein 5
81
Calcium homeostasis modulator protein 5
203
5.4
48
0.38
CAHM5CAHM5Q8N5C1Q8N5C1
T-cell surface glycoprotein CD3 epsilon chain
119
T-cell surface glycoprotein CD3 gamma chain
104
7.0
50
0.29
CD3ECD3GP07766P09693adaptiveimmuneresponsealpha-betaTcellactivationapoptoticsignalingpathwaycalcium-mediatedsignalingCD4-positivealpha-betaTcellproliferationcellsurfacereceptorsignalingpathwaycerebellumdevelopmentdendritedevelopmentGprotein-coupledreceptorsignalingpathwaygamma-deltaTcellactivationnegativeregulationofgeneexpressionnegativeregulationofsmoothenedsignalingpathwaynegativethymicTcellselectionpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofgeneexpressionpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofTcellanergypositiveregulationofTcellproliferationpositivethymicTcellselectionprotein-containingcomplexassemblyregulationofapoptoticprocesssignalcomplexassemblysmoothenedsignalingpathwayTcellactivationTcellanergyTcellcostimulationTcellreceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathwayestablishmentormaintenanceofcellpolarityproteintransportregulationoflymphocyteapoptoticprocess
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
177
5.4
103
0.18
W5PUX0W5NRY1W5PUX0W5NRY1mitochondrialATPsynthesiscoupledelectrontransport
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
188
Transcription factor SPT20 homolog
237
6.8
71
0.21
TAF5LSP20HO75529Q8NEM7histoneacetylationhistoneH3acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationpositiveregulationoftranscriptionDNA-templatedregulationofDNArepairregulationofRNAsplicingregulationofsomaticstemcellpopulationmaintenanceregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedtranscriptionbyRNApolymeraseIIautophagygastrulation
Glutamate receptor
549
Protein cornichon homolog 2
9
6.8
77
0.19
G5E8H1CNIH2G5E8H1O35089localizationwithinmembranenegativeregulationofanterogradesynapticvesicletransportnegativeregulationofreceptorlocalizationtosynapseregulationofAMPAreceptoractivityregulationofmembranepotentialregulationofNMDAreceptoractivityregulationofpostsynapticneurotransmitterreceptoractivitysynaptictransmissionglutamatergicvesicle-mediatedtransport
DNA-directed RNA polymerases I and III subunit RPAC1
333
DNA-directed RNA polymerases I and III subunit RPAC2
107
5.2
73
0.26
RPAC1RPAC2O15160P0DPB6transcriptionbyRNApolymeraseItranscriptionDNA-templated
Mitochondrial import receptor subunit TOM40 homolog
354
Mitochondrial import receptor subunit TOM40 homolog
354
5.2
89
0.22
TOM40TOM40O96008O96008iontransportproteinimportintomitochondrialmatrixproteininsertionintomitochondrialoutermembraneproteintargetingtomitochondrion
Bestrophin
108
Bestrophin
185
6.0
96
0.17
E1BF86E1BF86E1BF86E1BF86
Insulin-like growth factor-binding protein 3
240
Insulin-like growth factor I
54
5.4
73
0.25
IBP3IGF1P17936P05019apoptoticprocessMAPKcascadenegativeregulationofcellpopulationproliferationnegativeregulationofproteinphosphorylationnegativeregulationofsignaltransductionnegativeregulationofsmoothmusclecellmigrationnegativeregulationofsmoothmusclecellproliferationosteoblastdifferentiationpositiveregulationofapoptoticprocesspositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmyoblastdifferentiationproteinphosphorylationregulationofcellgrowthregulationofglucosemetabolicprocessregulationofinsulin-likegrowthfactorreceptorsignalingpathwaytypeBpancreaticcellproliferationactivationofproteinkinaseBactivitybonemineralizationinvolvedinbonematurationcellactivationcellpopulationproliferationcellularresponsetoamyloid-betaERK1andERK2cascadeglycolatemetabolicprocessinsulin-likegrowthfactorreceptorsignalingpathwaymusclehypertrophymuscleorgandevelopmentmyoblastdifferentiationmyoblastproliferationmyotubecelldevelopmentnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofinterleukin-1betaproductionnegativeregulationofneuroinflammatoryresponsenegativeregulationofoocytedevelopmentnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftumornecrosisfactorproductionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcardiacmusclehypertrophypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRasproteinsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftrophectodermalcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseBsignalingproteinstabilizationproteoglycanbiosyntheticprocessRasproteinsignaltransductionregulationofgeneexpressionregulationofmulticellularorganismgrowthregulationofproteinphosphorylationresponsetoheatsignaltransductionskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationskeletalsystemdevelopmentwoundhealing
T-cell surface glycoprotein CD3 epsilon chain
122
T-cell surface glycoprotein CD3 gamma chain
104
7.0
50
0.28
CD3ECD3GP07766P09693adaptiveimmuneresponsealpha-betaTcellactivationapoptoticsignalingpathwaycalcium-mediatedsignalingCD4-positivealpha-betaTcellproliferationcellsurfacereceptorsignalingpathwaycerebellumdevelopmentdendritedevelopmentGprotein-coupledreceptorsignalingpathwaygamma-deltaTcellactivationnegativeregulationofgeneexpressionnegativeregulationofsmoothenedsignalingpathwaynegativethymicTcellselectionpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofgeneexpressionpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofTcellanergypositiveregulationofTcellproliferationpositivethymicTcellselectionprotein-containingcomplexassemblyregulationofapoptoticprocesssignalcomplexassemblysmoothenedsignalingpathwayTcellactivationTcellanergyTcellcostimulationTcellreceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathwayestablishmentormaintenanceofcellpolarityproteintransportregulationoflymphocyteapoptoticprocess
Immunoglobulin heavy constant alpha 1
192
Polymeric immunoglobulin receptor
486
5.4
62
0.3
IGHA1PIGRP01876P01833adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasisdetectionofchemicalstimulusinvolvedinsensoryperceptionofbittertasteepidermalgrowthfactorreceptorsignalingpathwayFcreceptorsignalingpathwayimmunoglobulintranscytosisinepithelialcellsmediatedbypolymericimmunoglobulinreceptorreceptorclustering
SWI/SNF complex subunit SMARCC2
486
Zinc finger protein ubi-d4
24
5.3
90
0.21
SMRC2REQUQ8TAQ2Q92785chromatinremodelingnegativeregulationoftranscriptionDNA-templatednervoussystemdevelopmentnucleosomedisassemblypositiveregulationofcelldifferentiationpositiveregulationofdouble-strandbreakrepairpositiveregulationofmyoblastdifferentiationpositiveregulationofTcelldifferentiationpositiveregulationoftranscriptionDNA-templatedregulationofG0toG1transitionregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofnucleotide-excisionrepairregulationoftranscriptionbyRNApolymeraseIIapoptoticprocessapoptoticsignalingpathwaynegativeregulationofmyeloidprogenitorcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofstemcellpopulationmaintenancepositiveregulationoftranscriptionbyRNApolymeraseII
28S ribosomal protein S16, mitochondrial
26
28S ribosomal protein S25, mitochondrial
139
6.9
50
0.29
RT16RT25P82915P82669mitochondrialtranslation
Dynactin subunit 6
128
Dynactin subunit 5
149
5.3
78
0.24
D0G6S1A0A286ZK88D0G6S1A0A286ZK88mitoticspindleorganizationaortadevelopmentcoronaryvasculaturedevelopmentventricularseptumdevelopment
Stimulator of interferon genes protein
148
Stimulator of interferon genes protein
148
5.3
66
0.29
A0A2R3XZB7A0A2R3XZB7A0A2R3XZB7A0A2R3XZB7activationofinnateimmuneresponsepositiveregulationoftypeIinterferonproduction
DNA-directed RNA polymerase II subunit RPB1
641
Transcription elongation factor A protein 1
301
5.3
nan
nan
RPB1TCEA1P24928P23193DNA-templatedtranscriptionterminationpositiveregulationofRNAsplicingregulationoftranscriptionDNA-templatedtranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIItranscriptionelongationfromRNApolymeraseIIpromotertranscriptionDNA-templated
DNA-directed RNA polymerase I subunit RPA2
535
DNA-directed RNA polymerase I subunit RPA49
85
6.8
79
0.19
RPA2RPA49Q9H9Y6Q9GZS1embryoimplantationneuralcrestformationnucleologenesisrRNAtranscriptionnucleolarlargerRNAtranscriptionbyRNApolymeraseIRNApolymeraseIpreinitiationcomplexassemblytranscriptionelongationfromRNApolymeraseIpromoter
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
225
5.2
81
0.24
NDUV1NDUV2P49821P19404aerobicrespirationmitochondrialATPsynthesiscoupledelectrontransportmitochondrialelectrontransportNADHtoubiquinoneprotonmotiveforce-drivenmitochondrialATPsynthesiscardiacmuscletissuedevelopmentnervoussystemdevelopment
Proteasome subunit beta type-3
129
Proteasome subunit beta type-10
70
6.8
67
0.22
PSB3PSB10P33672Q3T0T1proteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessimmunesystemprocess
28S ribosomal protein S6, mitochondrial
105
28S ribosomal protein S18c, mitochondrial
101
5.5
51
0.35
RT06RT18CP82931P82917mitochondrialtranslationtranslation
T-cell surface glycoprotein CD3 epsilon chain
119
T-cell surface glycoprotein CD3 gamma chain
107
6.8
54
0.27
CD3ECD3GP07766P09693adaptiveimmuneresponsealpha-betaTcellactivationapoptoticsignalingpathwaycalcium-mediatedsignalingCD4-positivealpha-betaTcellproliferationcellsurfacereceptorsignalingpathwaycerebellumdevelopmentdendritedevelopmentGprotein-coupledreceptorsignalingpathwaygamma-deltaTcellactivationnegativeregulationofgeneexpressionnegativeregulationofsmoothenedsignalingpathwaynegativethymicTcellselectionpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofgeneexpressionpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofTcellanergypositiveregulationofTcellproliferationpositivethymicTcellselectionprotein-containingcomplexassemblyregulationofapoptoticprocesssignalcomplexassemblysmoothenedsignalingpathwayTcellactivationTcellanergyTcellcostimulationTcellreceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathwayestablishmentormaintenanceofcellpolarityproteintransportregulationoflymphocyteapoptoticprocess
Angiotensin-converting enzyme 2
141
Angiotensin-converting enzyme 2
141
6.8
52
0.28
ACE2ACE2Q9BYF1Q9BYF1angiotensinmaturationangiotensin-mediateddrinkingbehaviorbloodvesseldiametermaintenancematernalprocessinvolvedinfemalepregnancymembranefusionnegativeregulationofERK1andERK2cascadenegativeregulationofsignalingreceptoractivitynegativeregulationofsmoothmusclecellproliferationpositiveregulationofaminoacidtransportpositiveregulationofcardiacmusclecontractionpositiveregulationofgapjunctionassemblypositiveregulationofL-prolineimportacrossplasmamembranepositiveregulationofreactiveoxygenspeciesmetabolicprocessreceptor-mediatedendocytosisofvirusbyhostcellreceptor-mediatedvirionattachmenttohostcellregulationofcardiacconductionregulationofcellpopulationproliferationregulationofcytokineproductionregulationofinflammatoryresponseregulationofsystemicarterialbloodpressurebyrenin-angiotensinregulationoftransmembranetransporteractivityregulationofvasoconstrictiontryptophantransportviralentryintohostcellvirallifecycle
Bestrophin-2
185
Bestrophin-2
108
5.5
100
0.18
BEST2BEST2Q8NFU1Q8NFU1membranedepolarizationsensoryperceptionofsmell
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
180
5.4
100
0.19
F1RVN1A0A287BG40F1RVN1A0A287BG40mitochondrialelectrontransportNADHtoubiquinonecardiacmuscletissuedevelopmentnervoussystemdevelopment
Potassium voltage-gated channel subfamily D member 2
236
Dipeptidyl-peptidase 6
43
8.7
58
0.2
KCND2A7E2E4Q9NZV8A7E2E4actionpotentialcellularresponsetohypoxiachemicalsynaptictransmissionlocomotorrhythmneuronalactionpotentialpotassiumiontransmembranetransportproteinhomooligomerizationregulationofiontransmembranetransportsensoryperceptionofpainproteolysis
T-cell surface glycoprotein CD3 delta chain
96
T-cell surface glycoprotein CD3 epsilon chain
122
5.0
65
0.31
CD3DCD3EP04234P07766adaptiveimmuneresponsealpha-betaTcellactivationcellsurfacereceptorsignalingpathwaypositivethymicTcellselectionTcellreceptorsignalingpathwayapoptoticsignalingpathwaycalcium-mediatedsignalingCD4-positivealpha-betaTcellproliferationcerebellumdevelopmentdendritedevelopmentGprotein-coupledreceptorsignalingpathwaygamma-deltaTcellactivationnegativeregulationofgeneexpressionnegativeregulationofsmoothenedsignalingpathwaynegativethymicTcellselectionpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofgeneexpressionpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofTcellanergypositiveregulationofTcellproliferationprotein-containingcomplexassemblyregulationofapoptoticprocesssignalcomplexassemblysmoothenedsignalingpathwayTcellactivationTcellanergyTcellcostimulationtransmembranereceptorproteintyrosinekinasesignalingpathway
Calcium homeostasis modulator protein 5
203
Calcium homeostasis modulator protein 5
80
5.0
56
0.35
CAHM5CAHM5Q8N5C1Q8N5C1
Pentraxin-related protein PTX3
318
Pentraxin-related protein PTX3
318
5.3
68
0.28
PTX3PTX3P26022P26022extracellularmatrixorganizationinflammatoryresponseinnateimmuneresponsenegativeregulationbyhostofviralexo-alpha-sialidaseactivitynegativeregulationbyhostofviralglycoproteinmetabolicprocessnegativeregulationbyhostofviralprocessnegativeregulationofexo-alpha-sialidaseactivitynegativeregulationofglycoproteinmetabolicprocessnegativeregulationofviralentryintohostcellopsonizationovariancumulusexpansionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphagocytosisresponsetoyeast
Immunoglobulin J chain
35
Immunoglobulin heavy constant mu
452
6.9
65
0.22
IGJIGHMP01591P01871adaptiveimmuneresponseantibacterialhumoralresponseglomerularfiltrationhumoralimmuneresponseimmuneresponseinnateimmuneresponsepositiveregulationofrespiratoryburstprotein-containingcomplexassemblyretinahomeostasisBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumphagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
28S ribosomal protein S16, mitochondrial
26
28S ribosomal protein S25, mitochondrial
141
7.0
48
0.3
RT16RT25P82915P82669mitochondrialtranslation
DNA-directed RNA polymerase I subunit RPA1
67
DNA-directed RNA polymerase I subunit RPA2
1098
7.0
77
0.19
RPA1RPA2O95602Q9H9Y6negativeregulationofproteinlocalizationtonucleolusembryoimplantationneuralcrestformationnucleologenesisrRNAtranscription
Isoform 1 of Extracellular calcium-sensing receptor
129
Isoform 1 of Extracellular calcium-sensing receptor
129
5.3
53
0.35
CASRCASRP41180-1P41180-1
T-cell surface glycoprotein CD3 epsilon chain
122
T-cell surface glycoprotein CD3 gamma chain
107
5.7
48
0.37
CD3ECD3GP07766P09693adaptiveimmuneresponsealpha-betaTcellactivationapoptoticsignalingpathwaycalcium-mediatedsignalingCD4-positivealpha-betaTcellproliferationcellsurfacereceptorsignalingpathwaycerebellumdevelopmentdendritedevelopmentGprotein-coupledreceptorsignalingpathwaygamma-deltaTcellactivationnegativeregulationofgeneexpressionnegativeregulationofsmoothenedsignalingpathwaynegativethymicTcellselectionpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofgeneexpressionpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofTcellanergypositiveregulationofTcellproliferationpositivethymicTcellselectionprotein-containingcomplexassemblyregulationofapoptoticprocesssignalcomplexassemblysmoothenedsignalingpathwayTcellactivationTcellanergyTcellcostimulationTcellreceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathwayestablishmentormaintenanceofcellpolarityproteintransportregulationoflymphocyteapoptoticprocess
Potassium voltage-gated channel, Shaw-related subfamily, member 1
104
Potassium voltage-gated channel, Shaw-related subfamily, member 1
83
4.7
74
0.29
Q3KNS8Q3KNS8Q3KNS8Q3KNS8proteinhomooligomerizationregulationofiontransmembranetransport
Stimulator of interferon genes protein
148
Stimulator of interferon genes protein
148
4.7
64
0.33
STINGSTINGQ86WV6Q86WV6activationofinnateimmuneresponseautophagosomeassemblycellularresponsetoexogenousdsRNAcellularresponsetointerferon-betacellularresponsetoorganiccycliccompounddefenseresponsetovirusinnateimmuneresponsepositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofinterferon-betaproductionpositiveregulationofmacroautophagypositiveregulationofproteinbindingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftypeIinterferonproductionpositiveregulationoftypeIinterferon-mediatedsignalingpathwayproteincomplexoligomerizationregulationofinflammatoryresponsereticulophagy
Glycerol kinase
354
Glycerol kinase
354
7.1
98
0.14
A0A287BD08A0A287BD08A0A287BD08A0A287BD08glycerolcatabolicprocessglycerolmetabolicprocessglycerol-3-phosphatebiosyntheticprocessphosphorylationtriglyceridemetabolicprocess
Potassium voltage-gated channel subfamily C member 1
83
Potassium voltage-gated channel subfamily C member 1
104
4.2
71
0.34
KCNC1KCNC1P48547P48547cellularresponsetoxenobioticstimuluscerebellumdevelopmentglobuspallidusdevelopmentpositiveregulationofvoltage-gatedpotassiumchannelactivitypotassiumiontransmembranetransportpotassiumiontransportproteinhomooligomerizationproteintetramerizationresponsetoamineresponsetoauditorystimulusresponsetofibroblastgrowthfactorresponsetolightintensityresponsetonervegrowthfactorresponsetopotassiumionresponsetotoxicsubstance
Anaphase-promoting complex subunit 10
36
Anaphase-promoting complex subunit 1
1288
7.1
64
0.22
APC10APC1Q9UM13Q9H1A4anaphase-promotingcomplex-dependentcatabolicprocesscellcyclecelldivisionproteinK11-linkedubiquitinationregulationofmeioticcellcycleregulationofmitoticcellcyclemetaphase/anaphasetransitionofmitoticcellcycle
Bestrophin
189
Bestrophin
108
4.7
99
0.22
E1BF86E1BF86E1BF86E1BF86
THO complex subunit 2
500
THO complex subunit 3
258
5.3
78
0.24
THOC2THOC3Q8NI27Q96J01blastocystdevelopmentcellmorphogenesisgenerationofneuronsmRNAexportfromnucleusmRNAprocessingnegativeregulationofneuronprojectiondevelopmentneurondevelopmentpoly(A)+mRNAexportfromnucleusregulationofgeneexpressionregulationofmRNAexportfromnucleusRNAsplicingstemcelldivisionviralmRNAexportfromhostcellnucleus
Insulin-like growth factor-binding protein 3
240
Insulin-like growth factor I
96
6.8
69
0.21
IBP3IGF1P17936P05019apoptoticprocessMAPKcascadenegativeregulationofcellpopulationproliferationnegativeregulationofproteinphosphorylationnegativeregulationofsignaltransductionnegativeregulationofsmoothmusclecellmigrationnegativeregulationofsmoothmusclecellproliferationosteoblastdifferentiationpositiveregulationofapoptoticprocesspositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmyoblastdifferentiationproteinphosphorylationregulationofcellgrowthregulationofglucosemetabolicprocessregulationofinsulin-likegrowthfactorreceptorsignalingpathwaytypeBpancreaticcellproliferationactivationofproteinkinaseBactivitybonemineralizationinvolvedinbonematurationcellactivationcellpopulationproliferationcellularresponsetoamyloid-betaERK1andERK2cascadeglycolatemetabolicprocessinsulin-likegrowthfactorreceptorsignalingpathwaymusclehypertrophymuscleorgandevelopmentmyoblastdifferentiationmyoblastproliferationmyotubecelldevelopmentnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofinterleukin-1betaproductionnegativeregulationofneuroinflammatoryresponsenegativeregulationofoocytedevelopmentnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftumornecrosisfactorproductionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcardiacmusclehypertrophypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRasproteinsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftrophectodermalcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseBsignalingproteinstabilizationproteoglycanbiosyntheticprocessRasproteinsignaltransductionregulationofgeneexpressionregulationofmulticellularorganismgrowthregulationofproteinphosphorylationresponsetoheatsignaltransductionskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationskeletalsystemdevelopmentwoundhealing
Zinc finger CCHC domain-containing protein 8
56
Zinc finger CCHC domain-containing protein 8
56
5.3
50
0.38
ZCHC8ZCHC8Q6NZY4Q6NZY4mRNAsplicingviaspliceosomencRNAprocessingsnRNAcatabolicprocess
THO complex subunit 2
503
THO complex subunit 3
261
7.3
88
0.16
THOC2THOC3Q8NI27Q96J01blastocystdevelopmentcellmorphogenesisgenerationofneuronsmRNAexportfromnucleusmRNAprocessingnegativeregulationofneuronprojectiondevelopmentneurondevelopmentpoly(A)+mRNAexportfromnucleusregulationofgeneexpressionregulationofmRNAexportfromnucleusRNAsplicingstemcelldivisionviralmRNAexportfromhostcellnucleus
Beta-2-microglobulin
100
Beta-2-microglobulin
45
5.0
78
0.26
B2MGB2MGP61769P61769amyloidfibrilformationantibacterialhumoralresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofexogenousproteinantigenviaMHCclassIbTAP-dependentantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetoironioncellularresponsetoiron(III)ioncellularresponsetolipopolysaccharidecellularresponsetonicotinedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseironionhomeostasisironiontransportlearningormemorynegativeregulationofepithelialcellproliferationnegativeregulationofforebrainneurondifferentiationnegativeregulationofneurogenesisnegativeregulationofneuronprojectiondevelopmentnegativeregulationofreceptorbindingpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofcellularsenescencepositiveregulationofferrousironbindingpositiveregulationofproteinbindingpositiveregulationofreceptorbindingpositiveregulationofreceptor-mediatedendocytosispositiveregulationofTcellactivationpositiveregulationofTcellcytokineproductionpositiveregulationofTcellmediatedcytotoxicitypositiveregulationoftransferrinreceptorbindingproteinhomotetramerizationproteinrefoldingregulationoferythrocytedifferentiationregulationofironiontransportregulationofmembranedepolarizationresponsetomoleculeofbacterialoriginretinahomeostasissensoryperceptionofsmellTcelldifferentiationinthymusTcellmediatedcytotoxicity
Endoribonuclease Dicer
284
RISC-loading complex subunit TARBP2
325
9.5
76
0.14
DICERTRBP2Q9UPY3Q15633apoptoticDNAfragmentationglobalgenesilencingbymRNAcleavagemiRNAmetabolicprocessmiRNAprocessingnegativeregulationofgeneexpressionnegativeregulationofSchwanncellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftumornecrosisfactorproductionnervedevelopmentneuronprojectionmorphogenesisNIK/NF-kappaBsignalingperipheralnervoussystemmyelinformationpositiveregulationofmyelinationpositiveregulationofSchwanncelldifferentiationpre-miRNAprocessingRISCcomplexassemblyRNAphosphodiesterbondhydrolysisRNAphosphodiesterbondhydrolysisendonucleolyticsiRNAprocessingtRNAcatabolicprocessmulticellularorganismgrowthnegativeregulationofdefenseresponsetovirusbyhostnegativeregulationofproteinkinaseactivityneuralprecursorcellproliferationpositiveregulationofmusclecelldifferentiationpositiveregulationoftranslationpositiveregulationofviralgenomereplicationregulationofmiRNAmaturationregulationofproductionofsmallRNAinvolvedingenesilencingbyRNAregulationofviraltranscriptionsinglefertilizationskeletalmuscletissueregenerationspermatiddevelopment
von Willebrand factor
1142
von Willebrand factor
1142
3.3
65
0.47
VWFVWFP04275P04275bloodcoagulationcelladhesioncell-substrateadhesionhemostasisplateletactivationpositiveregulationofintracellularsignaltransductionresponsetowounding
Neurotensin receptor type 1
171
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
8.9
67
0.17
NTR1GNAI1P30989P63096adultlocomotorybehaviorchemicalsynaptictransmissionD-aspartateimportacrossplasmamembranedetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainGprotein-coupledreceptorsignalingpathwayinositolphosphatecatabolicprocessL-glutamateimportacrossplasmamembranelearningnegativeregulationofapoptoticprocessnegativeregulationofreleaseofsequesteredcalciumionintocytosolnegativeregulationofsystemicarterialbloodpressureneuropeptidesignalingpathwaypositiveregulationofapoptoticprocesspositiveregulationofarachidonicacidsecretionpositiveregulationofcationchannelactivitypositiveregulationofgamma-aminobutyricacidsecretionpositiveregulationofgeneexpressionpositiveregulationofglutamatesecretionpositiveregulationofinhibitorypostsynapticpotentialpositiveregulationofinositolphosphatebiosyntheticprocesspositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofreleaseofsequesteredcalciumionintocytosolregulationofactionpotentialregulationofmembranedepolarizationregulationofrespiratorygaseousexchangeregulationofsensoryperceptionofpainresponsetolipidtemperaturehomeostasisadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinpositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormone
Glutamate receptor ionotropic, NMDA 1
79
Glutamate receptor ionotropic, NMDA 2A
320
9.5
67
0.16
NMDZ1NMDE1P35439Q00959adultlocomotorybehaviorassociativelearningcalciumionhomeostasiscalciumiontransmembraneimportintocytosolcalciumiontransportcationtransmembranetransportcationtransportcellularcalciumionhomeostasiscellularresponsetomanganeseioncerebralcortexdevelopmentchemicalsynaptictransmissionconditionedtasteaversionexcitatorypostsynapticpotentialionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylong-termmemorymalematingbehaviormemorynegativeregulationofneuronapoptoticprocessneuromuscularprocessolfactorylearningponsmaturationpositiveregulationofapoptoticprocesspositiveregulationofcalciumiontransportintocytosolpositiveregulationofcelldeathpositiveregulationofcysteine-typeendopeptidaseactivitypositiveregulationofdendriticspinemaintenancepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofSchwanncellmigrationpositiveregulationofsynaptictransmissionglutamatergicpositiveregulationoftranscriptionbyRNApolymeraseIIprepulseinhibitionpropylenemetabolicprocessproteinheterotetramerizationproteinlocalizationtopostsynapticmembraneprotein-containingcomplexassemblyregulationofaxonogenesisregulationofcationtransmembranetransportregulationofcellcommunicationregulationofdendritemorphogenesisregulationoflong-termneuronalsynapticplasticityregulationofmembranepotentialregulationofneuronapoptoticprocessregulationofneuronalsynapticplasticityregulationofrespiratorygaseousexchangeregulationofsynapseassemblyregulationofsynapticplasticityresponsetoamineresponsetoamphetamineresponsetocalciumionresponsetoethanolresponsetofungicideresponsetoglycineresponsetomorphineresponsetoorganiccycliccompoundrhythmicprocesssensoryperceptionofpainsocialbehaviorstartleresponsesucklingbehaviorsynaptictransmissionglutamatergicvisuallearningactionpotentialcellularresponsetoaminoacidstimuluscellularresponsetodsRNAcellularresponsetogrowthfactorstimuluscellularresponsetolipidcellularresponsetomagnesiumioncellularresponsetozinciondendriticspineorganizationdirectionallocomotiondopaminemetabolicprocesshippocampusdevelopmentlocomotionlong-termsynapticpotentiationmodulationofchemicalsynaptictransmissionnegativeregulationofproteincatabolicprocessneurogenesisregulationofNMDAreceptoractivityregulationofpostsynapticmembranepotentialresponsetoammoniumionresponsetocarbohydrateresponsetococaineresponsetolightstimulusresponsetomanganeseionresponsetomethylmercuryresponsetootherorganismresponsetowoundingresponsetoxenobioticstimulusserotoninmetabolicprocesssleepspinalcorddevelopment
Glutamate receptor ionotropic, kainate 3
99
Glutamate receptor ionotropic, kainate 3
350
8.5
61
0.19
GRIK3GRIK3P42264P42264chemicalsynaptictransmissionGprotein-coupledglutamatereceptorsignalingpathwayglutamatereceptorsignalingpathwaymodulationofchemicalsynaptictransmissionnegativeregulationofsynaptictransmissionglutamatergicregulationofmembranepotentialsynaptictransmissionglutamatergic
Volume-regulated anion channel subunit LRRC8D
809
Volume-regulated anion channel subunit LRRC8D
687
9.2
74
0.15
LRC8DLRC8DQ7L1W4Q7L1W4aniontransmembranetransportaspartatetransmembranetransportcellularglucosehomeostasiscellularresponsetoosmoticstressproteinhexamerizationtaurinetransport
Glutamate receptor 1
603
Glutamate receptor 2
610
8.8
83
0.14
GRIA1GRIA2P19490P19491cellularresponsetoaminestimuluscellularresponsetoaminoacidstimuluscellularresponsetoammoniumioncellularresponsetodsRNAcellularresponsetogrowthfactorstimuluscellularresponsetoorganiccycliccompoundcellularresponsetopeptidehormonestimuluschemicalsynaptictransmissionlong-termmemorylong-termsynapticdepressionmodulationofchemicalsynaptictransmissionneuronalactionpotentialpositiveregulationofmembranepotentialpositiveregulationofsynaptictransmissionreceptorinternalizationregulationofpostsynapticmembranepotentialregulationofreceptorrecyclingregulationofsynapticplasticityresponsetoarsenic-containingsubstanceresponsetococaineresponsetoelectricalstimulusresponsetoestradiolresponsetofungicideresponsetolithiumionresponsetoorganiccycliccompoundresponsetopeptidehormoneresponsetotoxicsubstanceresponsetoxenobioticstimulusspinalcorddevelopmentsynaptictransmissionglutamatergicestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwayproteintetramerizationregulationofsynaptictransmissionglutamatergic
C-C motif chemokine 20
32
C-C chemokine receptor type 6
36
8.8
66
0.17
CCL20CCR6P78556P51684antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecalcium-mediatedsignalingusingintracellularcalciumsourcecellchemotaxiscell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisdefenseresponsetobacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofTcellmigrationsignaltransductionTcellmigrationthymocytemigrationcalcium-mediatedsignalingcellulardefenseresponsedendriticcellchemotaxisDN2thymocytedifferentiationDN3thymocytedifferentiationhumoralimmuneresponseisotypeswitchingtoIgAisotypesleukocytemigrationinvolvedininflammatoryresponselymphocytemigrationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofdendriticcellchemotaxispositiveregulationofflagellatedspermmotilityinvolvedincapacitationregulationofTcellmigration
Insulin-like growth factor-binding protein 3
213
Insulin-like growth factor I
96
8.1
60
0.21
IBP3IGF1P17936P05019apoptoticprocessMAPKcascadenegativeregulationofcellpopulationproliferationnegativeregulationofproteinphosphorylationnegativeregulationofsignaltransductionnegativeregulationofsmoothmusclecellmigrationnegativeregulationofsmoothmusclecellproliferationosteoblastdifferentiationpositiveregulationofapoptoticprocesspositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmyoblastdifferentiationproteinphosphorylationregulationofcellgrowthregulationofglucosemetabolicprocessregulationofinsulin-likegrowthfactorreceptorsignalingpathwaytypeBpancreaticcellproliferationactivationofproteinkinaseBactivitybonemineralizationinvolvedinbonematurationcellactivationcellpopulationproliferationcellularresponsetoamyloid-betaERK1andERK2cascadeglycolatemetabolicprocessinsulin-likegrowthfactorreceptorsignalingpathwaymusclehypertrophymuscleorgandevelopmentmyoblastdifferentiationmyoblastproliferationmyotubecelldevelopmentnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofinterleukin-1betaproductionnegativeregulationofneuroinflammatoryresponsenegativeregulationofoocytedevelopmentnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftumornecrosisfactorproductionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcardiacmusclehypertrophypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRasproteinsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftrophectodermalcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseBsignalingproteinstabilizationproteoglycanbiosyntheticprocessRasproteinsignaltransductionregulationofgeneexpressionregulationofmulticellularorganismgrowthregulationofproteinphosphorylationresponsetoheatsignaltransductionskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationskeletalsystemdevelopmentwoundhealing
Igh protein
478
Immunoglobulin J chain
123
9.0
65
0.17
Q99M22IGJQ99M22P01592adaptiveimmuneresponseantibacterialhumoralresponseglomerularfiltrationhumoralimmuneresponseinnateimmuneresponsepositiveregulationofrespiratoryburstprotein-containingcomplexassembly
Glial cell line-derived neurotrophic factor
210
Glial cell line-derived neurotrophic factor
178
8.5
nan
nan
GDNFGDNFP39905P39905adultlocomotorybehaviorbranchinginvolvedinuretericbudmorphogenesiscommissuralneuronaxonguidancedorsalspinalcorddevelopmentembryonicorgandevelopmententericnervoussystemdevelopmentmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesismetanephrosdevelopmentmRNAstabilizationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofneuronapoptoticprocessnervoussystemdevelopmentneuralcrestcellmigrationneuronprojectiondevelopmentorganinductionperipheralnervoussystemdevelopmentperistalsispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofdopaminesecretionpositiveregulationofmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesispositiveregulationofmonooxygenaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofuretericbudformationpostganglionicparasympatheticfiberdevelopmentpostsynapticmembraneorganizationregulationofdopamineuptakeinvolvedinsynaptictransmissionregulationofgeneexpressionregulationofmorphogenesisofabranchingstructureregulationofsemaphorin-plexinsignalingpathwayregulationofstemcelldifferentiationsignaltransductionsympatheticnervoussystemdevelopmenturetericbudformation
Splicing factor 3B subunit 1
677
PHD finger-like domain-containing protein 5A
11
8.5
61
0.19
SF3B1PHF5AO75533Q7RTV0chromatinremodelingmRNAsplicingviaspliceosomepositiveregulationofhistoneacetylationpositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIRNAsplicingRNAsplicingviatransesterificationreactionsspliceosomalcomplexassemblyU2-typeprespliceosomeassemblypositiveregulationoftranscriptionDNA-templatedstemcelldifferentiation
DNA-directed RNA polymerase III subunit RPC1
1126
DNA-directed RNA polymerase III subunit RPC10
20
9.9
50
0.2
RPC1RPC10O14802Q9Y2Y1defenseresponsetovirusinnateimmuneresponsepositiveregulationofinterferon-betaproductiontranscriptionDNA-templatedterminationofRNApolymeraseIIItranscriptiontranscriptionbyRNApolymeraseIII"tRNA3-trailercleavage"
Glycoprotein hormones alpha chain
55
Thyrotropin subunit beta
72
8.8
81
0.14
GLHATSHBP01215P01222follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegenerationanatomicalstructuremorphogenesiscell-cellsignalingresponsetocalciumionresponsetoestrogenresponsetovitaminA
Sodium channel protein type 4 subunit alpha
1024
Sodium channel subunit beta-1
181
8.8
59
0.19
SCN4ASCN1BP35499Q07699membranedepolarizationduringactionpotentialmusclecontractionneuronalactionpotentialregulationofiontransmembranetransportregulationofskeletalmusclecontractionbyactionpotentialsodiumiontransmembranetransportsodiumiontransportaxonguidancecardiacconductioncardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractioncelladhesioncorticospinalneuronaxonguidancelocomotionmembranedepolarizationmembranedepolarizationduringcardiacmusclecellactionpotentialmembranedepolarizationduringPurkinjemyocytecellactionpotentialneuronalactionpotentialpropagationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofsodiumiontransportregulationofatrialcardiacmusclecellmembranedepolarizationregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityregulationofventricularcardiacmusclecellmembranerepolarization
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
524
Phosphoinositide 3-kinase regulatory subunit 5
123
8.8
64
0.18
PK3CGPI3R5P48736O02696adaptiveimmuneresponseangiogenesiscellmigrationcellularresponsetocAMPdendriticcellchemotaxisendocytosisGprotein-coupledreceptorsignalingpathwayhepatocyteapoptoticprocessimmuneresponseinflammatoryresponseinnateimmuneresponsemastcelldegranulationnaturalkillercellchemotaxisnegativeregulationofcardiacmusclecontractionnegativeregulationoffibroblastapoptoticprocessnegativeregulationoftriglyceridecatabolicprocessneutrophilchemotaxisneutrophilextravasationphosphatidylinositol3-kinasesignalingphosphatidylinositolphosphatebiosyntheticprocessphosphatidylinositol-3-phosphatebiosyntheticprocessphosphatidylinositol-mediatedsignalingphosphorylationplateletaggregationpositiveregulationofacuteinflammatoryresponsepositiveregulationofcytokineproductionpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofendothelialcellmigrationpositiveregulationofMAPkinaseactivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofRacproteinsignaltransductionproteinphosphorylationregulationofcalciumiontransmembranetransportregulationofcelladhesionmediatedbyintegrinrespiratoryburstinvolvedindefenseresponsesecretorygranulelocalizationsphingosine-1-phosphatereceptorsignalingpathwayTcellactivationTcellchemotaxisTcellproliferation
ATP-binding cassette sub-family D member 1
511
ATP-binding cassette sub-family D member 1
717
9.6
52
0.2
ABCD1ABCD1P33897P33897alpha-linolenicacidmetabolicprocessfattyacidbeta-oxidationfattyacidelongationfattyacidhomeostasislinoleicacidmetabolicprocesslong-chainfattyacidcatabolicprocesslong-chainfattyacidimportintoperoxisomemyelinmaintenancenegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationofreactiveoxygenspeciesbiosyntheticprocessneuronprojectionmaintenanceperoxisomalmembranetransportperoxisomeorganizationpositiveregulationoffattyacidbeta-oxidationpositiveregulationofunsaturatedfattyacidbiosyntheticprocessregulationofcellularresponsetooxidativestressregulationoffattyacidbeta-oxidationregulationofmitochondrialdepolarizationregulationofoxidativephosphorylationsterolhomeostasisverylong-chainfattyacidcatabolicprocessverylong-chainfattyacidmetabolicprocessverylong-chainfatty-acyl-CoAcatabolicprocess
N-formyl peptide receptor 2
63
Guanine nucleotide-binding protein G(i) subunit alpha-2
352
8.8
79
0.14
FPR2GNAI2P25090P04899adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayastrocyteactivationcalcium-mediatedsignalingcelladhesioncellsurfacereceptorsignalingpathwaycellularresponsetoamyloid-betachemotaxiscomplementreceptormediatedsignalingpathwaydefenseresponsetobacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponse-regulatingcellsurfacereceptorsignalingpathwayinflammatoryresponsemicroglialcellactivationnegativeregulationofinflammatoryresponsephospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositivechemotaxispositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofinnateimmuneresponsepositiveregulationofmonocytechemotaxispositiveregulationofphagocytosispositiveregulationofproteinphosphorylationpositiveregulationofsuperoxideaniongenerationreceptor-mediatedendocytosisadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellpopulationproliferationGprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledadenosinereceptorsignalingpathwaygamma-aminobutyricacidsignalingpathwaynegativeregulationofadenylatecyclaseactivitynegativeregulationofadenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocessnegativeregulationofapoptoticsignalingpathwaynegativeregulationofcalciumion-dependentexocytosisnegativeregulationofproteintyrosinephosphataseactivitynegativeregulationofsynaptictransmissionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofNAD(P)Hoxidaseactivitypositiveregulationofneuralprecursorcellproliferationpositiveregulationofrenalsodiumexcretionpositiveregulationofurinevolumepositiveregulationofvascularassociatedsmoothmusclecellproliferationregulationofcalciumiontransportresponsetonutrientsignaltransduction
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
245
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
72
8.9
85
0.13
STT3ADAD1P46977P61803co-translationalproteinmodificationpost-translationalproteinmodificationproteinN-linkedglycosylationproteinN-linkedglycosylationviaasparagineapoptoticprocessblastocystdevelopmentnegativeregulationofapoptoticprocessproteinglycosylationregulationofproteinstabilityresponsetonutrientresponsetoxenobioticstimulus
C-C chemokine receptor type 2
32
C-C motif chemokine 2
34
8.7
64
0.18
CCR2CCL2P41597P13500bloodvesselremodelingcalcium-mediatedsignalingcellchemotaxiscellularcalciumionhomeostasiscellulardefenseresponsecellularhomeostasischemokine-mediatedsignalingpathwaychemotaxiscytokine-mediatedsignalingpathwaydendriticcellchemotaxisimmuneresponseinflammatoryresponseinflammatoryresponsetowoundingmacrophagemigrationmonocyteextravasationnegativeregulationofadenylatecyclaseactivitynegativeregulationofangiogenesisnegativeregulationofeosinophildegranulationnegativeregulationoftype2immuneresponsepositiveregulationofalpha-betaTcellproliferationpositiveregulationofastrocytechemotaxispositiveregulationofCD8-positivealpha-betaTcellextravasationpositiveregulationofcold-inducedthermogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofhematopoieticstemcellmigrationpositiveregulationofimmunecomplexclearancebymonocytesandmacrophagespositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-2productionpositiveregulationofmonocytechemotaxispositiveregulationofmonocyteextravasationpositiveregulationofNMDAglutamatereceptoractivitypositiveregulationofsynaptictransmissionglutamatergicpositiveregulationofTcellactivationpositiveregulationofTcellchemotaxispositiveregulationofT-helper1typeimmuneresponsepositiveregulationofthymocytemigrationpositiveregulationoftumornecrosisfactorproductionreceptorsignalingpathwayviaJAK-STATregulationofinflammatoryresponseregulationofTcellcytokineproductionregulationofTcelldifferentiationregulationofvascularendothelialgrowthfactorproductionresponsetowoundingsensoryperceptionofpainT-helper17cellchemotaxisangiogenesisanimalorganmorphogenesisastrocytecellmigrationcelladhesioncellsurfacereceptorsignalingpathwaycellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetolipopolysaccharidecellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcytoskeletonorganizationeosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerhelperTcellextravasationhumoralimmuneresponselipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofglialcellapoptoticprocessnegativeregulationofnaturalkillercellchemotaxisnegativeregulationofneuronapoptoticprocessnegativeregulationofvascularendothelialcellproliferationneutrophilchemotaxispositiveregulationofapoptoticcellclearancepositiveregulationofcalciumionimportpositiveregulationofendothelialcellapoptoticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofnitric-oxidesynthasebiosyntheticprocessproteinkinaseBsignalingproteinphosphorylationregulationofcellshaperesponsetobacteriumsignaltransductionviralgenomereplication
Sodium channel subunit beta-1
181
Sodium channel protein type 3 subunit alpha
1199
8.7
62
0.19
SCN1BSCN3AQ07699Q9NY46axonguidancecardiacconductioncardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractioncelladhesioncorticospinalneuronaxonguidancelocomotionmembranedepolarizationmembranedepolarizationduringcardiacmusclecellactionpotentialmembranedepolarizationduringPurkinjemyocytecellactionpotentialneuronalactionpotentialpropagationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofsodiumiontransportregulationofatrialcardiacmusclecellmembranedepolarizationregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityregulationofventricularcardiacmusclecellmembranerepolarizationsodiumiontransmembranetransportmembranedepolarizationduringactionpotentialneuronalactionpotentialregulationofiontransmembranetransportsodiumiontransport
Dynactin subunit 6
148
Dynactin subunit 5
149
8.8
62
0.18
D0G6S1A0A286ZK88D0G6S1A0A286ZK88mitoticspindleorganizationaortadevelopmentcoronaryvasculaturedevelopmentventricularseptumdevelopment
THO complex subunit 2
500
THO complex subunit 3
261
5.5
82
0.22
THOC2THOC3Q8NI27Q96J01blastocystdevelopmentcellmorphogenesisgenerationofneuronsmRNAexportfromnucleusmRNAprocessingnegativeregulationofneuronprojectiondevelopmentneurondevelopmentpoly(A)+mRNAexportfromnucleusregulationofgeneexpressionregulationofmRNAexportfromnucleusRNAsplicingstemcelldivisionviralmRNAexportfromhostcellnucleus
Insulin
109
Insulin
43
3.9
58
0.44
INSINSP01308P01318activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealingcellularresponsetopalmitoleicacidresponsetoL-arginine
Caveolin-1
133
Caveolin-1
143
5.5
48
0.38
CAV1CAV1Q03135Q03135angiogenesisangiotensin-activatedsignalingpathwayinvolvedinheartprocessapoptoticsignalingpathwaybasementmembraneorganizationcalciumionhomeostasiscalciumiontransportcaveolaassemblycaveolin-mediatedendocytosiscelldifferentiationcellularcalciumionhomeostasiscellularresponsetoexogenousdsRNAcellularresponsetohyperoxiacellularresponsetopeptidehormonestimuluscellularresponsetostarvationcellularresponsetotransforminggrowthfactorbetastimuluscholesterolhomeostasischolesteroltransportcytokine-mediatedsignalingpathwayendothelialcellproliferationestablishmentoflocalizationincellfibroblastproliferationglandularepithelialcelldifferentiationinsulinreceptorinternalizationlactationlipidstoragemaintenanceofproteinlocationincellmammaryglanddevelopmentmammaryglandinvolutionMAPKcascademembranedepolarizationmusclecellcellularhomeostasisnegativeregulationofanoikisnegativeregulationofBMPsignalingpathwaynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcytokine-mediatedsignalingpathwaynegativeregulationofendothelialcellproliferationnegativeregulationofepithelialcelldifferentiationnegativeregulationoffibroblastproliferationnegativeregulationofinwardrectifierpotassiumchannelactivitynegativeregulationofMAPkinaseactivitynegativeregulationofMAPKcascadenegativeregulationofnecroptoticprocessnegativeregulationofnitricoxidebiosyntheticprocessnegativeregulationofnitric-oxidesynthaseactivitynegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofpeptidyl-tyrosineautophosphorylationnegativeregulationofpinocytosisnegativeregulationofpotassiumiontransmembranetransportnegativeregulationofproteinbindingnegativeregulationofproteintyrosinekinaseactivitynegativeregulationofproteinubiquitinationnegativeregulationofreceptorsignalingpathwayviaJAK-STATnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationoftyrosinephosphorylationofSTATproteinnitricoxidebiosyntheticprocessnitricoxidehomeostasispositiveregulationofcalciumiontransportintocytosolpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcatalyticactivitypositiveregulationofcelladhesionmoleculeproductionpositiveregulationofcellmigrationpositiveregulationofcholesteroleffluxpositiveregulationofcold-inducedthermogenesispositiveregulationofER-associatedubiquitin-dependentproteincatabolicprocesspositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofgapjunctionassemblypositiveregulationofgeneexpressionpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinubiquitinationpositiveregulationoftoll-likereceptor3signalingpathwaypositiveregulationofvasoconstrictionpost-transcriptionalregulationofgeneexpressionproteinlocalizationproteinlocalizationtobasolateralplasmamembraneproteinlocalizationtoplasmamembraneraftproteintransportreceptorinternalizationreceptorinternalizationinvolvedincanonicalWntsignalingpathwayreceptor-mediatedendocytosisofvirusbyhostcellregulationofbloodcoagulationregulationofcardiacmusclecellactionpotentialinvolvedinregulationofcontractionregulationofcellcommunicationbyelectricalcouplinginvolvedincardiacconductionregulationofcytosoliccalciumionconcentrationregulationofentryofbacteriumintohostcellregulationoffattyacidmetabolicprocessregulationofheartratebycardiacconductionregulationofmembranerepolarizationduringactionpotentialregulationofpeptidaseactivityregulationofruffleassemblyregulationofsmoothmusclecontractionregulationoftheforceofheartcontractionbychemicalsignalregulationofventricularcardiacmusclecellactionpotentialresponsetobacteriumresponsetocalciumionresponsetoestrogenresponsetohypoxiaresponsetoischemiaresponsetoprogesteroneskeletalmuscletissuedevelopmentTcellcostimulationtriglyceridemetabolicprocesstyrosinephosphorylationofSTATproteinvasculogenesisvasoconstrictionvesicleorganization
Protein tweety homolog 2
101
Protein tweety homolog 2
101
5.0
73
0.27
TTYH2TTYH2Q3TH73Q3TH73
28S ribosomal protein S6, mitochondrial
105
28S ribosomal protein S18c, mitochondrial
69
5.0
50
0.4
RT06RT18CP82931P82917mitochondrialtranslationtranslation
Protein kinase, cAMP dependent regulatory, type II alpha
99
cAMP-dependent protein kinase catalytic subunit alpha
200
5.1
69
0.29
Q8K1M3KAPCAQ8K1M3P05132phosphorylationcellularresponsetocoldcellularresponsetoglucosestimuluscellularresponsetoheatcellularresponsetoparathyroidhormonestimulusmesodermformationmodulationofchemicalsynaptictransmissionmRNAprocessingnegativeregulationofmeioticcellcyclenegativeregulationofsmoothenedsignalingpathwayinvolvedindorsal/ventralneuraltubepatterningneuraltubeclosurepeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofcellpopulationproliferationpositiveregulationofproteinexportfromnucleusproteinautophosphorylationproteinexportfromnucleusproteinkinaseAsignalingproteinlocalizationtolipiddropletproteinphosphorylationregulationofbicellulartightjunctionassemblyregulationofcellcycleregulationofcellularrespirationregulationofosteoblastdifferentiationregulationofproteasomalproteincatabolicprocessregulationofproteinprocessingregulationofsynaptictransmissionglutamatergicspermcapacitationspontaneousexocytosisofneurotransmitter
Isoform 1 of Extracellular calcium-sensing receptor
131
Isoform 1 of Extracellular calcium-sensing receptor
131
5.0
48
0.42
CASRCASRP41180-1P41180-1
Voltage-dependent anion-selective channel protein 2
47
Voltage-dependent anion-selective channel protein 2
103
8.8
36
0.32
F1S2F6F1S2F6F1S2F6F1S2F6
DNA-directed RNA polymerase III subunit RPC10
25
DNA-directed RNA polymerase III subunit RPC5
70
9.7
60
0.17
RPC10RPC5Q9Y2Y1Q9NVU0defenseresponsetovirusinnateimmuneresponseterminationofRNApolymeraseIIItranscriptiontranscriptionbyRNApolymeraseIII"tRNA3-trailercleavage"transcriptionDNA-templated
Muscarinic acetylcholine receptor M2
443
Guanine nucleotide-binding protein G(o) subunit alpha
351
8.7
67
0.17
ACM2GNAOP08172P09471adenylatecyclase-inhibitingGprotein-coupledacetylcholinereceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaychemicalsynaptictransmissionGprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengernervoussystemdevelopmentphospholipaseC-activatingGprotein-coupledacetylcholinereceptorsignalingpathwayregulationofheartcontractionregulationofsmoothmusclecontractionregulationofsynapticvesicleexocytosisresponsetovirusdopaminereceptorsignalingpathwaymusclecontraction
Glutamate receptor
610
Glutamate receptor 1
603
6.0
81
0.21
G5E8H1GRIA1G5E8H1P23818cellularresponsetoammoniumionchemicalsynaptictransmissionlong-termmemorylong-termsynapticdepressionmodulationofchemicalsynaptictransmissionneuronalactionpotentialpositiveregulationofmembranepotentialpositiveregulationofsynaptictransmissionreceptorinternalizationregulationofpostsynapticmembranepotentialregulationofreceptorrecyclingregulationofsynapticplasticityresponsetotoxicsubstance
Dedicator of cytokinesis protein 2
41
Engulfment and cell motility protein 1
726
9.1
nan
nan
DOCK2ELMO1Q92608Q92556actincytoskeletonorganizationalpha-betaTcellproliferationcellmigrationchemotaxisestablishmentofTcellpolarityimmunologicalsynapseformationmacropinocytosismembraneraftpolarizationmyeloiddendriticcellactivationinvolvedinimmuneresponsemyoblastfusionnegativethymicTcellselectionpositiveregulationofphagocytosispositivethymicTcellselectionregulationofsmallGTPasemediatedsignaltransductionsmallGTPasemediatedsignaltransductionactinfilamentorganizationactinfilament-basedprocessapoptoticprocesscellmotilityphagocytosisengulfmentRacproteinsignaltransductionregulationofcatalyticactivity
DNA-directed RNA polymerase III subunit RPC10
20
DNA-directed RNA polymerase III subunit RPC5
70
9.5
50
0.21
RPC10RPC5Q9Y2Y1Q9NVU0defenseresponsetovirusinnateimmuneresponseterminationofRNApolymeraseIIItranscriptiontranscriptionbyRNApolymeraseIII"tRNA3-trailercleavage"transcriptionDNA-templated
Centromere protein L
286
Centromere protein N
293
9.8
60
0.17
CENPLCENPNQ8N0S6Q96H22chromosomesegregationkinetochoreassembly
Insulin-like growth factor-binding protein 3
213
Insulin-like growth factor I
54
6.8
64
0.23
IBP3IGF1P17936P05019apoptoticprocessMAPKcascadenegativeregulationofcellpopulationproliferationnegativeregulationofproteinphosphorylationnegativeregulationofsignaltransductionnegativeregulationofsmoothmusclecellmigrationnegativeregulationofsmoothmusclecellproliferationosteoblastdifferentiationpositiveregulationofapoptoticprocesspositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmyoblastdifferentiationproteinphosphorylationregulationofcellgrowthregulationofglucosemetabolicprocessregulationofinsulin-likegrowthfactorreceptorsignalingpathwaytypeBpancreaticcellproliferationactivationofproteinkinaseBactivitybonemineralizationinvolvedinbonematurationcellactivationcellpopulationproliferationcellularresponsetoamyloid-betaERK1andERK2cascadeglycolatemetabolicprocessinsulin-likegrowthfactorreceptorsignalingpathwaymusclehypertrophymuscleorgandevelopmentmyoblastdifferentiationmyoblastproliferationmyotubecelldevelopmentnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofinterleukin-1betaproductionnegativeregulationofneuroinflammatoryresponsenegativeregulationofoocytedevelopmentnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftumornecrosisfactorproductionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcardiacmusclehypertrophypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRasproteinsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftrophectodermalcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseBsignalingproteinstabilizationproteoglycanbiosyntheticprocessRasproteinsignaltransductionregulationofgeneexpressionregulationofmulticellularorganismgrowthregulationofproteinphosphorylationresponsetoheatsignaltransductionskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationskeletalsystemdevelopmentwoundhealing
Glutamate receptor
549
Protein cornichon homolog 2
9
6.6
84
0.18
C9K0Z0CNIH2C9K0Z0O35089localizationwithinmembranenegativeregulationofanterogradesynapticvesicletransportnegativeregulationofreceptorlocalizationtosynapseregulationofAMPAreceptoractivityregulationofmembranepotentialregulationofNMDAreceptoractivityregulationofpostsynapticneurotransmitterreceptoractivitysynaptictransmissionglutamatergicvesicle-mediatedtransport
Sodium channel protein type 9 subunit alpha
895
Sodium channel subunit beta-2
55
4.1
67
0.37
SCN9ASCN2BQ15858O60939behavioralresponsetoformalininducedpaininflammatoryresponsemembranedepolarizationduringactionpotentialnegativeregulationofactionpotentialneuronalactionpotentialpost-embryonicdevelopmentregulationofiontransmembranetransportresponsetocoldresponsetoheatresponsetotoxicsubstancesensoryperceptionofpainsodiumiontransmembranetransportsodiumiontransportcardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractionchemicalsynaptictransmissiongeneexpressionmembranedepolarizationduringcardiacmusclecellactionpotentialnervoussystemdevelopmentregulationofatrialcardiacmusclecellmembranedepolarizationregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityresponsetopyrethroid
Diacylglycerol O-acyltransferase 1
92
Diacylglycerol O-acyltransferase 1
92
6.1
44
0.37
DGAT1DGAT1O75907O75907diacylglycerolmetabolicprocessfattyacidhomeostasislipidstoragelong-chainfatty-acyl-CoAmetabolicprocessmonoacylglycerolbiosyntheticprocesstriglyceridebiosyntheticprocesstriglyceridemetabolicprocessvery-low-densitylipoproteinparticleassembly
Replication factor C subunit 3
285
Cell cycle checkpoint protein RAD17
540
5.6
75
0.24
RFC3RAD17P40938O75943DNAduplexunwindingDNArepairDNAreplicationDNAstrandelongationinvolvedinDNAreplicationDNAsynthesisinvolvedinDNArepairDNA-templatedDNAreplicationpositiveregulationofDNA-directedDNApolymeraseactivityresponsetoorganophosphoruscellularresponsetoDNAdamagestimulusDNAdamagecheckpointsignalingDNAreplicationcheckpointsignalingmitoticDNAreplicationcheckpointsignalingmitoticintra-SDNAdamagecheckpointsignalingnegativeregulationofDNAreplicationregulationofphosphorylation
Glutamate receptor 2
549
Protein cornichon homolog 2
9
6.4
83
0.19
GRIA2CNIH2P19491Q5BJU5chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumionlocalizationwithinmembranenegativeregulationofanterogradesynapticvesicletransportnegativeregulationofreceptorlocalizationtosynapseregulationofAMPAreceptoractivityregulationofmembranepotentialregulationofNMDAreceptoractivityregulationofpostsynapticneurotransmitterreceptoractivitysynaptictransmissionglutamatergicvesicle-mediatedtransport
LHFPL tetraspan subfamily member 5 protein
35
LHFPL tetraspan subfamily member 5 protein
35
5.0
78
0.26
LHPL5LHPL5Q4KL25Q4KL25auditoryreceptorcellstereociliumorganizationdetectionofmechanicalstimulusinvolvedinsensoryperceptiondetectionofmechanicalstimulusinvolvedinsensoryperceptionofsoundiontransportsensoryperceptionofsound
Muscarinic acetylcholine receptor M2
124
Guanine nucleotide-binding protein G(o) subunit alpha
351
6.2
75
0.21
ACM2GNAOP08172P09471adenylatecyclase-inhibitingGprotein-coupledacetylcholinereceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaychemicalsynaptictransmissionGprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengernervoussystemdevelopmentphospholipaseC-activatingGprotein-coupledacetylcholinereceptorsignalingpathwayregulationofheartcontractionregulationofsmoothmusclecontractionregulationofsynapticvesicleexocytosisresponsetovirusdopaminereceptorsignalingpathwaymusclecontraction
Ig kappa-b4 chain C region
103
IgG heavy chain VDJ region
134
6.7
nan
nan
KAC4A0A1Y1B8B1P01840A0A1Y1B8B1
Eukaryotic translation initiation factor 3 subunit C
443
40S ribosomal protein S27
59
4.9
70
0.29
EIF3CRS27Q99613P42677formationofcytoplasmictranslationinitiationcomplexpositiveregulationofmRNAbindingpositiveregulationoftranslationtranslationalinitiationcytoplasmictranslationribosomalsmallsubunitassemblyrRNAprocessingtranslation
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
524
Phosphoinositide 3-kinase regulatory subunit 5
120
3.4
57
0.51
PK3CGPI3R5P48736O02696adaptiveimmuneresponseangiogenesiscellmigrationcellularresponsetocAMPdendriticcellchemotaxisendocytosisGprotein-coupledreceptorsignalingpathwayhepatocyteapoptoticprocessimmuneresponseinflammatoryresponseinnateimmuneresponsemastcelldegranulationnaturalkillercellchemotaxisnegativeregulationofcardiacmusclecontractionnegativeregulationoffibroblastapoptoticprocessnegativeregulationoftriglyceridecatabolicprocessneutrophilchemotaxisneutrophilextravasationphosphatidylinositol3-kinasesignalingphosphatidylinositolphosphatebiosyntheticprocessphosphatidylinositol-3-phosphatebiosyntheticprocessphosphatidylinositol-mediatedsignalingphosphorylationplateletaggregationpositiveregulationofacuteinflammatoryresponsepositiveregulationofcytokineproductionpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofendothelialcellmigrationpositiveregulationofMAPkinaseactivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofRacproteinsignaltransductionproteinphosphorylationregulationofcalciumiontransmembranetransportregulationofcelladhesionmediatedbyintegrinrespiratoryburstinvolvedindefenseresponsesecretorygranulelocalizationsphingosine-1-phosphatereceptorsignalingpathwayTcellactivationTcellchemotaxisTcellproliferation
ATPase GET3
289
ATPase GET3
289
3.5
60
0.48
GET3GET3O43681O43681post-translationalproteintargetingtoendoplasmicreticulummembraneproteininsertionintoERmembranetail-anchoredmembraneproteininsertionintoERmembrane
Tropomyosin alpha-1 chain
190
Tropomyosin alpha-1 chain
190
4.8
55
0.38
1
✔TPM1TPM1P09493P09493actinfilamentorganizationcardiacmusclecontractioncellularresponsetoreactiveoxygenspeciescytoskeletonorganizationmusclecontractionmusclefilamentslidingnegativeregulationofcellmigrationnegativeregulationofvascularassociatedsmoothmusclecellmigrationnegativeregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofATP-dependentactivitypositiveregulationofcelladhesionpositiveregulationofheartratebyepinephrinepositiveregulationofstressfiberassemblyregulationofcellshaperegulationofheartcontractionregulationofmusclecontractionruffleorganizationsarcomereorganizationventricularcardiacmuscletissuemorphogenesiswoundhealing
Mediator of RNA polymerase II transcription subunit 10
84
Mediator of RNA polymerase II transcription subunit 14
115
4.4
67
0.34
MED10MED14Q9BTT4O60244positiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterpositiveregulationoftranscriptioninitiationfromRNApolymeraseIIpromoterRNApolymeraseIIpreinitiationcomplexassemblypositiveregulationoftranscriptionDNA-templatedregulationoftranscriptionbyRNApolymeraseIIsomaticstemcellpopulationmaintenance
Transient receptor potential cation channel subfamily V member 1
623
Transient receptor potential cation channel subfamily V member 1
623
4.5
54
0.41
I3LZN5I3LZN5I3LZN5I3LZN5behavioralresponsetopaincalciumionimportacrossplasmamembranecellularresponsetoacidicpHcellularresponsetoheatdetectionofchemicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinthermoceptiondietinducedthermogenesisfevergenerationlipidmetabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIIpeptidesecretionresponsetocapsazepinesensoryperceptionofmechanicalstimulussmoothmusclecontractioninvolvedinmicturition
DNA replication licensing factor MCM3
243
DNA replication licensing factor MCM5
221
4.3
77
0.3
MCM3MCM5P25205P33992DNAreplicationinitiationDNAstrandelongationinvolvedinDNAreplicationDNAunwindinginvolvedinDNAreplicationdouble-strandbreakrepairviabreak-inducedreplicationmitoticDNAreplicationinitiationregulationofDNA-templatedDNAreplicationinitiationcellcycleDNAreplication
Serine/threonine-protein kinase SMG1
492
Nonsense-mediated mRNA decay factor SMG9
380
4.5
69
0.32
SMG1SMG9Q96Q15Q9H0W8DNArepairmRNAexportfromnucleusnegativeregulationofmacroautophagynuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecaypeptidyl-serinephosphorylationphosphatidylinositolphosphatebiosyntheticprocessproteinautophosphorylationproteinphosphorylationregulationofresponsetoDNAdamagestimulusregulationoftelomeremaintenanceTORsignalingbraindevelopmenteyedevelopmentheartdevelopmentinuteroembryonicdevelopment
Potassium voltage-gated channel subfamily D member 2
111
Potassium voltage-gated channel subfamily D member 2
133
4.5
65
0.34
A0A6P6DHQ6A0A6P6DHQ6A0A6P6DHQ6A0A6P6DHQ6proteinhomooligomerizationregulationofiontransmembranetransport
E3 ubiquitin-protein ligase ARIH1
357
Ubiquitin-conjugating enzyme E2 L3
86
4.5
64
0.35
ARI1UB2L3Q9Y4X5P68036positiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationproteinubiquitinationubiquitin-dependentproteincatabolicprocesscellcyclephasetransitioncellpopulationproliferationcellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluspositiveregulationofproteintargetingtomitochondrionpositiveregulationofproteinubiquitinationpositiveregulationofubiquitin-proteintransferaseactivityproteinK11-linkedubiquitinationproteinmodificationprocessregulationoftranscriptionDNA-templated
Protein tweety homolog 1
102
Protein tweety homolog 1
102
4.3
82
0.29
TTYH1TTYH1Q9H313Q9H313cell-celladhesioncell-substrateadhesionchloridetransportfilopodiumassemblyiontransmembranetransportironiontransportmitoticcellcycle
Voltage-dependent anion-selective channel protein 2
103
Voltage-dependent anion-selective channel protein 2
210
4.2
50
0.48
F1S2F6F1S2F6F1S2F6F1S2F6
Acylglycerol kinase, mitochondrial
43
Mitochondrial import inner membrane translocase subunit Tim29
149
4.3
69
0.33
AGKTIM29Q53H12Q9BSF4ceramidebiosyntheticprocessglycerolipidmetabolicprocessphosphorylationproteininsertionintomitochondrialinnermembranesphingolipidmetabolicprocess
Broad substrate specificity ATP-binding cassette transporter ABCG2
544
Broad substrate specificity ATP-binding cassette transporter ABCG2
544
4.4
80
0.28
ABCG2ABCG2Q9UNQ0Q9UNQ0biotintransportcellulardetoxificationexportacrossplasmamembranelipidtransportorganicaniontransportrenaluratesaltexcretionriboflavintransporttransepithelialtransporttransmembranetransporttransportacrossblood-brainbarrieruratemetabolicprocessxenobiotictransportacrossblood-brainbarrier
Integrator complex subunit 2
722
Integrator complex subunit 7
42
7.1
79
0.18
INT2INT7Q9H0H0Q9NVH2regulationoftranscriptionelongationfromRNApolymeraseIIpromoter"snRNA3-endprocessing"snRNAprocessingcellularresponsetoionizingradiationDNAdamagecheckpointsignaling
Mucin-2
1088
Mucin-2
1088
4.3
76
0.31
A0A0G2JR65A0A0G2JR65A0A0G2JR65A0A0G2JR65
Choline transporter-like protein 1
485
Choline transporter-like protein 1
485
5.8
42
0.41
CTL1CTL1Q8WWI5Q8WWI5cholinecatabolicprocesscholinetransportphosphatidylcholinebiosyntheticprocesstransmembranetransporttransportacrossblood-brainbarrier
Tropomyosin alpha-1 chain
190
Tropomyosin alpha-1 chain
190
6.3
64
0.25
1
✔TPM1TPM1P58771P58771actinfilamentcappingactinfilamentorganizationcardiacmusclecontractioninuteroembryonicdevelopmentmusclecontractionmusclefilamentslidingnegativeregulationofcellmigrationnegativeregulationofvascularassociatedsmoothmusclecellmigrationnegativeregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofATP-dependentactivitypositiveregulationofcelladhesionpositiveregulationofheartratebyepinephrinepositiveregulationofstressfiberassemblyregulationofATP-dependentactivityregulationofcellshaperuffleorganizationsarcomereorganizationventricularcardiacmuscletissuemorphogenesiswoundhealing
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
241
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
72
6.1
86
0.19
STT3ADAD1P46977P61803co-translationalproteinmodificationpost-translationalproteinmodificationproteinN-linkedglycosylationproteinN-linkedglycosylationviaasparagineapoptoticprocessblastocystdevelopmentnegativeregulationofapoptoticprocessproteinglycosylationregulationofproteinstabilityresponsetonutrientresponsetoxenobioticstimulus
Prothrombin
336
Prothrombin
482
2.0
70
0.71
THRBTHRBP00734P00734acute-phaseresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidebloodcoagulationbloodcoagulationcommonpathwaycellsurfacereceptorsignalingpathwaycytolysisbyhostofsymbiontcellsfibrinolysisnegativeregulationofastrocytedifferentiationnegativeregulationofbloodcoagulationnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationoffibrinolysisnegativeregulationofplateletactivationnegativeregulationofproteolysisneutrophil-mediatedkillingofgram-negativebacteriumplateletactivationpositiveregulationofbloodcoagulationpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationoflipidkinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinphosphorylationpositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofreleaseofsequesteredcalciumionintocytosolproteolysisregulationofbloodcoagulationregulationofcellshaperegulationofcytosoliccalciumionconcentrationresponsetowoundingzymogenactivation
Insulin
107
Insulin
43
2.0
57
0.87
INSINSP01315P01315activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessglycoproteinbiosyntheticprocessinsulinreceptorsignalingpathwaylactatebiosyntheticprocesslipidbiosyntheticprocesslipoproteinbiosyntheticprocessnegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofDNAreplicationpositiveregulationoffattyacidbiosyntheticprocesspositiveregulationofglucoseimportpositiveregulationofglucosemetabolicprocesspositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipoproteinlipaseactivitypositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationtoplasmamembraneregulationoftransmembranetransporteractivityresponsetoL-argininevasodilationwoundhealing
Insulin
94
Insulin
31
2.0
45
1.11
INSINSP01315P01315activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessglycoproteinbiosyntheticprocessinsulinreceptorsignalingpathwaylactatebiosyntheticprocesslipidbiosyntheticprocesslipoproteinbiosyntheticprocessnegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofDNAreplicationpositiveregulationoffattyacidbiosyntheticprocesspositiveregulationofglucoseimportpositiveregulationofglucosemetabolicprocesspositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipoproteinlipaseactivitypositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationtoplasmamembraneregulationoftransmembranetransporteractivityresponsetoL-argininevasodilationwoundhealing
Insulin
96
Insulin
31
2.1
65
0.72
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
Insulin
109
Insulin
43
2.0
47
1.05
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
Chymotrypsinogen A
136
Chymotrypsinogen A
201
2.0
70
0.7
CTRACTRAP00766P00766digestionproteolysis
Phenylethanolamine N-methyltransferase
48
Phenylethanolamine N-methyltransferase
139
2.0
67
0.73
PNMTPNMTP11086P11086catecholaminebiosyntheticprocessepinephrinebiosyntheticprocessmethylation
Coagulation factor X
342
Coagulation factor X
172
2.0
82
0.6
FA10FA10P00742P00742bloodcoagulationbloodcoagulationcommonpathwaypositiveregulationofcellmigrationpositiveregulationofproteinkinaseBsignalingproteolysiszymogenactivation
Coagulation factor VII
195
Coagulation factor VII
322
2.0
85
0.58
FA7FA7P08709P08709activationofbloodcoagulationviaclottingcascadeanimalorganregenerationbloodcoagulationbloodcoagulationextrinsicpathwaybloodcoagulationfibrinclotformationbloodcoagulationintrinsicpathwaycircadianrhythmpositiveregulationofbloodcoagulationpositiveregulationofcellmigrationpositiveregulationofleukocytechemotaxispositiveregulationofplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofpositivechemotaxispositiveregulationofproteinkinaseBsignalingproteinprocessingproteolysisresponseto2378-tetrachlorodibenzodioxineresponsetoanticoagulantresponsetoastaxanthinresponsetocarbondioxideresponsetocholesterolresponsetoestradiolresponsetoestrogenresponsetogenisteinresponsetogrowthhormoneresponsetohypoxiaresponsetoThyroidstimulatinghormoneresponsetothyrotropin-releasinghormoneresponsetothyroxineresponsetovitaminKresponsetowoundingzymogenactivation
Macrophage colony-stimulating factor 1
63
Macrophage colony-stimulating factor 1
63
2.0
68
0.72
CSF1CSF1P09603P09603branchinginvolvedinmammaryglandductmorphogenesisdevelopmentalprocessinvolvedinreproductionhomeostasisofnumberofcellswithinatissueinflammatoryresponseinnateimmuneresponsemacrophagecolony-stimulatingfactorsignalingpathwaymacrophagedifferentiationmacrophagehomeostasismammaryductterminalendbudgrowthmammaryglandfatdevelopmentmicroglialcellproliferationmonocyteactivationmonocytedifferentiationmonocytehomeostasismyeloidleukocytemigrationnegativeregulationofneurondeathneutrophilhomeostasisodontogenesisossificationosteoclastdifferentiationosteoclastproliferationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-matrixadhesionpositiveregulationofgeneexpressionpositiveregulationofmacrophagechemotaxispositiveregulationofmacrophagecolony-stimulatingfactorsignalingpathwaypositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofmacrophagedifferentiationpositiveregulationofmacrophagemigrationpositiveregulationofmicroglialcellmigrationpositiveregulationofmonocytedifferentiationpositiveregulationofmononuclearcellproliferationpositiveregulationofmulticellularorganismgrowthpositiveregulationofodontogenesisofdentin-containingtoothpositiveregulationofosteoclastdifferentiationpositiveregulationofproteinkinaseactivitypositiveregulationofproteinmetabolicprocesspositiveregulationofRasproteinsignaltransductionRasproteinsignaltransductionregulationofmacrophagederivedfoamcelldifferentiationregulationofossificationresponsetoischemiatransmembranereceptorproteintyrosinekinasesignalingpathway
Fibrinogen alpha chain
180
Fibrinogen gamma chain
161
2.0
85
0.58
FIBAFIBGP02671Q53Y18adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-1cellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Macrophage colony-stimulating factor 1
63
Macrophage colony-stimulating factor 1
63
2.0
52
0.95
CSF1CSF1P07141P07141branchinginvolvedinmammaryglandductmorphogenesiscellpopulationproliferationdevelopmentalprocessinvolvedinreproductionhomeostasisofnumberofcellswithinatissueinflammatoryresponseinnateimmuneresponsemacrophagecolony-stimulatingfactorsignalingpathwaymacrophagedifferentiationmacrophagehomeostasismammaryductterminalendbudgrowthmammaryglandfatdevelopmentmicroglialcellproliferationmonocytedifferentiationmonocytehomeostasismyeloidleukocytemigrationnegativeregulationofneurondeathneutrophilhomeostasisodontogenesisossificationosteoclastdifferentiationosteoclastproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-matrixadhesionpositiveregulationofgeneexpressionpositiveregulationofleukocytemigrationpositiveregulationofmacrophagechemotaxispositiveregulationofmacrophagecolony-stimulatingfactorsignalingpathwaypositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofmacrophagedifferentiationpositiveregulationofmacrophagemigrationpositiveregulationofmicroglialcellmigrationpositiveregulationofmonocytedifferentiationpositiveregulationofmononuclearcellproliferationpositiveregulationofmulticellularorganismgrowthpositiveregulationofodontogenesisofdentin-containingtoothpositiveregulationofosteoclastdifferentiationpositiveregulationofproteinkinaseactivitypositiveregulationofproteinmetabolicprocesspositiveregulationofRasproteinsignaltransductionRasproteinsignaltransductionregulationofossificationresponsetoischemiatransmembranereceptorproteintyrosinekinasesignalingpathway
Allograft inflammatory factor 1-like
35
Allograft inflammatory factor 1-like
35
2.0
60
0.82
AIF1LAIF1LQ9BQI0Q9BQI0actinfilamentbundleassemblyruffleassembly
Indoleamine 2,3-dioxygenase 1
308
Indoleamine 2,3-dioxygenase 1
308
2.0
69
0.71
I23O1I23O1P14902P14902"denovoNADbiosyntheticprocessfromtryptophan"femalepregnancyinflammatoryresponsekynurenicacidbiosyntheticprocessmulticellularorganismalresponsetostressnegativeregulationofinterleukin-10productionnegativeregulationofTcellapoptoticprocessnegativeregulationofTcellproliferationpositiveregulationofchronicinflammatoryresponsepositiveregulationofinterleukin-12productionpositiveregulationofTcellapoptoticprocesspositiveregulationofTcelltoleranceinductionpositiveregulationoftype2immuneresponseresponsetolipopolysaccharideswimmingbehaviorTcellproliferationtryptophancatabolicprocesstryptophancatabolicprocesstokynurenine
Interleukin-12 subunit beta
199
Interleukin-23 subunit alpha
73
2.0
49
1.0
IL12BIL23AP29460Q9NPF7cellmigrationcellularresponsetointerferon-gammacellularresponsetolipopolysaccharidecytokine-mediatedsignalingpathwaydefenseresponsetoGram-negativebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponsenaturalkillercellactivationnaturalkillercellactivationinvolvedinimmuneresponsenegativeregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisnegativeregulationofinflammatoryresponsetoantigenicstimulusnegativeregulationofinterleukin-10productionnegativeregulationofinterleukin-17productionnegativeregulationofproteinsecretionnegativeregulationofsmoothmusclecellproliferationnegativeregulationofvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofactivatedTcellproliferationpositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcelladhesionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-17productionpositiveregulationoflymphocyteproliferationpositiveregulationofmemoryTcelldifferentiationpositiveregulationofmononuclearcellproliferationpositiveregulationofnaturalkillercellactivationpositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationofnaturalkillercellproliferationpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofNKTcellactivationpositiveregulationofNKTcellproliferationpositiveregulationofosteoclastdifferentiationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellapoptoticprocesspositiveregulationofTcellmediatedcytotoxicitypositiveregulationofTcellproliferationpositiveregulationofT-helper1typeimmuneresponsepositiveregulationofT-helper17celllineagecommitmentpositiveregulationofT-helper17typeimmuneresponsepositiveregulationoftissueremodelingpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofcytokineproductionregulationoftyrosinephosphorylationofSTATproteinresponsetoUV-BsensoryperceptionofpainsexualreproductionTcellproliferationT-helper1typeimmuneresponseT-helpercelldifferentiationinflammatoryresponseinnateimmuneresponsepositiveregulationofneutrophilchemotaxispositiveregulationoftranscriptionbyRNApolymeraseIItissueremodeling
Kelch-like ECH-associated protein 1
434
Kelch-like ECH-associated protein 1
434
2.0
54
0.91
KEAP1KEAP1Q14145Q14145cellularresponsetointerleukin-4cellularresponsetooxidativestresscytoplasmicsequesteringoftranscriptionfactorinuteroembryonicdevelopmentnegativeregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteinubiquitinationregulationofautophagyregulationofepidermalcelldifferentiationubiquitin-dependentproteincatabolicprocess
DNA polymerase lambda
543
DNA polymerase lambda
543
2.0
39
1.26
DPOLLDPOLLQ9UGP5Q9UGP5base-excisionrepairgap-fillingDNAbiosyntheticprocessDNAreplicationdouble-strandbreakrepairviahomologousrecombinationdouble-strandbreakrepairvianonhomologousendjoiningnucleotide-excisionrepairsomatichypermutationofimmunoglobulingenes
Fibrinogen alpha chain
184
Fibrinogen beta chain
223
2.0
72
0.68
FIBAFIBBP02671P02675adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncelladhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulus
Transforming growth factor beta-1 proprotein
223
Transforming growth factor beta-1 proprotein
225
2.0
67
0.73
TGFB1TGFB1P07200P07200adaptiveimmuneresponsebasedonsomaticrecombinationofimmunereceptorsbuiltfromimmunoglobulinsuperfamilydomainsaorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaybranchelongationinvolvedinmammaryglandductbranchingbronchioledevelopmentcellmigrationcellmorphogenesiscell-celljunctionorganizationcellularcalciumionhomeostasiscellularresponsetoionizingradiationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetoviruschondrocytedifferentiationcolumnar/cuboidalepithelialcellmaturationcommon-partnerSMADproteinphosphorylationembryonicliverdevelopmentenamelmineralizationendodermdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialcellproliferationepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayfacemorphogenesisgeneexpressiongermcellmigrationhematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponseLangerhanscelldifferentiationlensfibercelldifferentiationlipopolysaccharide-mediatedsignalingpathwaylungalveolusdevelopmentlymphnodedevelopmentmammaryglandbranchinginvolvedinthelarcheMAPKcascademembraneproteinintracellulardomainproteolysismusclecellcellularhomeostasisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofepithelialcellproliferationnegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofinterleukin-17productionnegativeregulationofmacrophagecytokineproductionnegativeregulationofmyoblastdifferentiationnegativeregulationofossificationnegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationofTcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneuraltubeclosureNotchsignalingpathwayoligodendrocytedevelopmentossificationinvolvedinboneremodelingosteoclastdifferentiationpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocessphospholipidhomeostasispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofhistoneacetylationpositiveregulationofhistonedeacetylationpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofodontogenesispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorclusteringpositiveregulationofregulatoryTcelldifferentiationpositiveregulationofSMADproteinsignaltransductionpositiveregulationofstemcellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofactincytoskeletonreorganizationregulationofbindingregulationofbranchinginvolvedinmammaryglandductmorphogenesisregulationofcartilagedevelopmentregulationofcellpopulationproliferationregulationofDNAbindingregulationofinterleukin-23productionregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofsodiumiontransportregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulatoryTcelldifferentiationresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductionstemcellproliferationsurfactanthomeostasisTcellhomeostasisTcellproliferationtoleranceinductiontoselfantigentransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmenturetericbuddevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
Interleukin-12 subunit beta
197
Interleukin-12 subunit beta
197
2.0
39
1.26
IL12BIL12BP43432P43432cellmigrationcellpopulationproliferationcellsurfacereceptorsignalingpathwaycellularresponsetointerferon-gammacellularresponsetolipopolysaccharidecytokine-mediatedsignalingpathwaydefenseresponsetoGram-negativebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponsenaturalkillercellactivationnaturalkillercellactivationinvolvedinimmuneresponsenegativeregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisnegativeregulationofinflammatoryresponsetoantigenicstimulusnegativeregulationofinterleukin-10productionnegativeregulationofinterleukin-17productionnegativeregulationofproteinsecretionnegativeregulationofsmoothmusclecellproliferationnegativeregulationofvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofactivatedTcellproliferationpositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcelladhesionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-17productionpositiveregulationoflymphocyteproliferationpositiveregulationofmononuclearcellproliferationpositiveregulationofnaturalkillercellactivationpositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationofnaturalkillercellproliferationpositiveregulationofNKTcellactivationpositiveregulationofNKTcellproliferationpositiveregulationofosteoclastdifferentiationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellapoptoticprocesspositiveregulationofTcellmediatedcytotoxicitypositiveregulationofTcellproliferationpositiveregulationofT-helper1typeimmuneresponsepositiveregulationofT-helper17typeimmuneresponsepositiveregulationoftumornecrosisfactorproductionpositiveregulationoftyrosinephosphorylationofSTATproteinregulationoftyrosinephosphorylationofSTATproteinresponsetoorganicsubstanceresponsetoUV-BsensoryperceptionofpainTcellproliferationT-helpercelldifferentiation
Vascular endothelial growth factor A
77
Vascular endothelial growth factor A
86
2.0
76
0.65
VEGFAVEGFAP15692P15692activationofproteinkinaseactivityangiogenesisarterymorphogenesisbasophilchemotaxisbranchinginvolvedinbloodvesselmorphogenesiscamera-typeeyemorphogenesiscardiacmusclecelldevelopmentcardiacvascularsmoothmusclecelldevelopmentcellmaturationcellmigrationinvolvedinsproutingangiogenesiscellularresponsetohypoxiacellularresponsetovascularendothelialgrowthfactorstimuluscellularstressresponsetoacidchemicalcommissuralneuronaxonguidancecoronaryarterymorphogenesiscoronaryveinmorphogenesisdopaminergicneurondifferentiationendothelialcellchemotaxisepithelialcelldifferentiationeyephotoreceptorcelldevelopmentheartmorphogenesisinuteroembryonicdevelopmentinductionofpositivechemotaxiskidneydevelopmentlactationlungdevelopmentlymphvesselmorphogenesismacrophagedifferentiationmammaryglandalveolusdevelopmentmesodermdevelopmentmonocytedifferentiationmotorneuronmigrationnegativeregulationofadherensjunctionorganizationnegativeregulationofapoptoticprocessnegativeregulationofblood-brainbarrierpermeabilitynegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofestablishmentofendothelialbarriernegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentoutflowtractmorphogenesisovarianfollicledevelopmentpositivechemotaxispositiveregulationofangiogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelladhesionpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellmigrationbyvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofcellproliferationbyVEGF-activatedplateletderivedgrowthfactorreceptorsignalingpathwaypositiveregulationofcold-inducedthermogenesispositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialtubeformationpositiveregulationofERK1andERK2cascadepositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofhistonedeacetylaseactivitypositiveregulationofleukocytemigrationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmastcellchemotaxispositiveregulationofneuroblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofpositivechemotaxispositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinkinaseCsignalingpositiveregulationofproteinkinaseDsignalingpositiveregulationofproteinlocalizationtoearlyendosomepositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorinternalizationpositiveregulationofretinalganglioncellaxonguidancepositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftrophoblastcellmigrationpositiveregulationofvascularpermeabilitypost-embryoniccamera-typeeyedevelopmentprimitiveerythrocytedifferentiationregulationofcellshaperegulationofnitricoxidemediatedsignaltransductionregulationofretinalganglioncellaxonguidanceregulationoftranscriptionbyRNApolymeraseIIresponsetohypoxiasproutingangiogenesissurfactanthomeostasistubeformationvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorreceptor-2signalingpathwayvascularendothelialgrowthfactorsignalingpathwayvascularwoundhealingvasculogenesisVEGF-activatedneuropilinsignalingpathway
Interleukin-6 receptor subunit beta
419
Interleukin-6 receptor subunit beta
419
2.0
66
0.74
IL6RBIL6RBP40189P40189ciliaryneurotrophicfactor-mediatedsignalingpathwaycytokine-mediatedsignalingpathwayglycogenmetabolicprocessinterleukin-27-mediatedsignalingpathwayinterleukin-6-mediatedsignalingpathwayintestinalepithelialcelldevelopmentleukemiainhibitoryfactorsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofinterleukin-6-mediatedsignalingpathwaynegativeregulationofneuronapoptoticprocessoncostatin-M-mediatedsignalingpathwaypositiveregulationofacuteinflammatoryresponsepositiveregulationofadaptiveimmuneresponsepositiveregulationofastrocytedifferentiationpositiveregulationofcardiacmusclehypertrophypositiveregulationofcellpopulationproliferationpositiveregulationofNotchsignalingpathwaypositiveregulationofosteoblastdifferentiationpositiveregulationofplateletaggregationpositiveregulationofTcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularendothelialgrowthfactorproductionresponsetocytokine
Complement C3
1513
Complement C3
873
2.0
75
0.66
CO3CO3P01024P01024amyloid-betaclearancecellsurfacereceptorsignalingpathwayinvolvedincell-cellsignalingcomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitycomplement-mediatedsynapsepruningfattyacidmetabolicprocessGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseneuronremodelingopsonizationoviductepitheliumdevelopmentpositiveregulationofactivationofmembraneattackcomplexpositiveregulationofangiogenesispositiveregulationofapoptoticcellclearancepositiveregulationofapoptoticprocessinanotherorganismpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofglucosetransmembranetransportpositiveregulationofimmuneresponsepositiveregulationoflipidstoragepositiveregulationofopsonizationpositiveregulationofphagocytosispositiveregulationofphagocytosisengulfmentpositiveregulationofproteinphosphorylationpositiveregulationofreceptor-mediatedendocytosispositiveregulationoftypeIIahypersensitivitypositiveregulationofvascularendothelialgrowthfactorproductionproteolysisregulationofcomplementactivationregulationofcomplementactivationalternativepathwayregulationoftriglyceridebiosyntheticprocessresponsetobacteriumsignaltransductionvertebrateeye-specificpatterning
Fibrinogen alpha chain
180
Fibrinogen gamma chain
161
2.0
85
0.58
FIBAFIBGP02671P02679adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-1cellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Insulin
104
Insulin
43
2.0
49
1.0
INSINSP01317P01317estradiolsecretionfeedingbehaviorglucoseimportinresponsetoinsulinstimulusglucosemetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofappetitenegativeregulationoflactationnegativeregulationoflipidcatabolicprocesspositiveregulationofbloodcirculationpositiveregulationofcellmaturationpositiveregulationofgeneexpressionpositiveregulationofinsulinsecretionpositiveregulationoflactationpositiveregulationofmammaryglandepithelialcellproliferationpositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRhoproteinsignaltransductionproteinsecretionresponsetobutyrateresponsetofoodresponsetoglucoseresponsetogrowthhormoneresponsetoheatresponsetoL-arginineresponsetonutrientlevels
Norrin
93
Norrin
95
2.0
80
0.61
NDPNDPQ00604Q00604decidualizationextracellularmatrix-cellsignalingnervoussystemdevelopmentNorrinsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoftranscriptionDNA-templatedretinavasculaturemorphogenesisincamera-typeeyevacuoleorganizationvisualperceptionWntsignalingpathway
Fibrinogen alpha chain
55
Fibrinogen beta chain
95
2.0
55
0.89
FIBAFIBBP02671P02675adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncelladhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulus
Seminal ribonuclease
58
Seminal ribonuclease
57
2.0
62
0.79
RNSRNSP00669P00669defenseresponsetoGram-positivebacteriumRNAphosphodiesterbondhydrolysis
Transforming growth factor beta-2 proprotein
379
Transforming growth factor beta-2 proprotein
379
2.0
76
0.65
TGFB2TGFB2P61812P61812activationofproteinkinaseactivityascendingaortamorphogenesisatrialseptummorphogenesisatrialseptumprimummorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwaycardiacepithelialtomesenchymaltransitioncardiacmusclecellproliferationcardiacrightventriclemorphogenesiscardioblastdifferentiationcelldeathcellmigrationcellmorphogenesiscell-celljunctionorganizationcollagenfibrilorganizationcranialskeletalsystemdevelopmentdopaminebiosyntheticprocessembryodevelopmentendinginbirthoregghatchingembryonicdigestivetractdevelopmentembryoniclimbmorphogenesisendocardialcushionfusionendocardialcushionmorphogenesisepithelialtomesenchymaltransitionextrinsicapoptoticsignalingpathwayeyedevelopmentgenerationofneuronsglialcellmigrationhairfollicledevelopmenthairfolliclemorphogenesisheartdevelopmentheartmorphogenesisheartvalvemorphogenesishemopoiesisinnereardevelopmentkidneydevelopmentmalegonaddevelopmentmembranousseptummorphogenesisnegativeregulationofalkalinephosphataseactivitynegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofepithelialcellproliferationnegativeregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationnegativeregulationofgeneexpressionnegativeregulationofmacrophagecytokineproductionnegativeregulationofRasproteinsignaltransductionneuralretinadevelopmentneuraltubeclosureneurondevelopmentneutrophilchemotaxisodontogenesisoutflowtractseptummorphogenesispathway-restrictedSMADproteinphosphorylationpharyngealarcharterymorphogenesispositiveregulationofcardioblastdifferentiationpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcellcyclepositiveregulationofcelldivisionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationpositiveregulationofheartcontractionpositiveregulationofimmuneresponsepositiveregulationofintegrinbiosyntheticprocesspositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationofNotchsignalingpathwaypositiveregulationofossificationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofstress-activatedMAPKcascadepositiveregulationoftimingofcatagenproteinphosphorylationpulmonaryvalvemorphogenesisregulationofapoptoticprocessinvolvedinoutflowtractmorphogenesisregulationofcellpopulationproliferationregulationoftimingofcatagenregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetoprogesteroneresponsetowoundingresponsetoxenobioticstimulussalivaryglandmorphogenesissecondarypalatedevelopmentskeletalsystemdevelopmentSMADproteinsignaltransductionsomaticstemcelldivisionsubstantiapropriaofcorneadevelopmenttransforminggrowthfactorbetareceptorsignalingpathwayuterinewallbreakdownuterusdevelopmentventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesiswoundhealing
Potassium channel subfamily K member 4
52
Potassium channel subfamily K member 4
52
2.0
43
1.14
KCNK4KCNK4Q9NYG8Q9NYG8cellularresponsetoalkalinepHcellularresponsetofattyacidcellularresponsetomechanicalstimuluscellularresponsetotemperaturestimulusdetectionofmechanicalstimulusinvolvedinsensoryperceptionoftouchmemorypotassiumiontransmembranetransportpotassiumiontransportregulationofiontransmembranetransportsensoryperceptionofpainsensoryperceptionoftemperaturestimulusstabilizationofmembranepotential
Human nkt tcr alpha chain
164
Human nkt tcr beta chain
176
2.0
75
0.66
K7N5M3K7N5M4K7N5M3K7N5M4
Myc proto-oncogene protein
438
Myc proto-oncogene protein
438
2.0
31
1.58
MYCMYCP01106P01106branchinginvolvedinuretericbudmorphogenesiscellularironionhomeostasiscellularresponsetoDNAdamagestimuluscellularresponsetohypoxiacellularresponsetoUVcellularresponsetoxenobioticstimuluschromatinremodelingchromosomeorganizationenergyreservemetabolicprocessERK1andERK2cascadefibroblastapoptoticprocessG1/StransitionofmitoticcellcycleMAPKcascadenegativeregulationofapoptoticprocessnegativeregulationofcelldivisionnegativeregulationoffibroblastproliferationnegativeregulationofmonocytedifferentiationnegativeregulationofstress-activatedMAPKcascadenegativeregulationoftranscriptionbyRNApolymeraseIIoxygentransportpositiveregulationofcellpopulationproliferationpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofDNAbiosyntheticprocesspositiveregulationofDNAmethylationpositiveregulationofepithelialcellproliferationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofmesenchymalcellproliferationpositiveregulationofmetanephriccapmesenchymalcellproliferationpositiveregulationofmiRNAtranscriptionpositiveregulationofresponsetoDNAdamagestimuluspositiveregulationoftelomeraseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprotein-DNAcomplexdisassemblyregulationofcellcycleprocessregulationofgeneexpressionregulationofsomaticstemcellpopulationmaintenanceregulationoftelomeremaintenanceregulationoftranscriptionbyRNApolymeraseIIresponsetogammaradiationresponsetogrowthfactorresponsetoxenobioticstimulus
Vesicle-associated membrane protein-associated protein B/C
53
Vesicle-associated membrane protein-associated protein B/C
53
2.0
79
0.62
VAPBVAPBO95292O95292cellularcalciumionhomeostasisCOPII-coatedvesiclebuddingendoplasmicreticulummembraneorganizationendoplasmicreticulumorganizationendoplasmicreticulumtoGolgivesicle-mediatedtransportendoplasmicreticulumunfoldedproteinresponseendoplasmicreticulum-plasmamembranetetheringIRE1-mediatedunfoldedproteinresponsemodulationbyhostofviralRNAgenomereplicationnegativeregulationbyhostofviralgenomereplicationnegativeregulationbyvirusofviralproteinlevelsinhostcellpositiveregulationbyhostofviralgenomereplicationpositiveregulationofviralgenomereplicationsuppressionofviralreleasebyhostviralreleasefromhostcell
Ig gamma-2A chain C region, A allele
110
Ig gamma-2A chain C region, A allele
110
2.0
30
1.64
GCAAGCAAP01863P01863BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationresponsetobacterium
Heat shock protein beta-1
137
Heat shock protein beta-1
137
2.0
60
0.82
HSPB1HSPB1P04792P04792anterogradeaxonalproteintransportcellularresponsetovascularendothelialgrowthfactorstimuluschaperone-mediatedproteinfoldingintracellularsignaltransductionnegativeregulationofapoptoticprocessnegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteinkinaseactivityplateletaggregationpositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofendothelialcellchemotaxispositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofinterleukin-1betaproductionpositiveregulationoftumornecrosisfactorproductionproteinrefoldingregulationofautophagyregulationofI-kappaBkinase/NF-kappaBsignalingregulationofproteinphosphorylationregulationoftranslationalinitiationresponsetoheatresponsetounfoldedproteinresponsetovirusretinahomeostasis
Fibrinogen alpha chain
68
Fibrinogen beta chain
106
2.0
83
0.59
FIBAFIBBP02671P02675adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncelladhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulus
Complement C3
559
Complement C3
816
2.0
79
0.62
CO3CO3P01024P01024amyloid-betaclearancecellsurfacereceptorsignalingpathwayinvolvedincell-cellsignalingcomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitycomplement-mediatedsynapsepruningfattyacidmetabolicprocessGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseneuronremodelingopsonizationoviductepitheliumdevelopmentpositiveregulationofactivationofmembraneattackcomplexpositiveregulationofangiogenesispositiveregulationofapoptoticcellclearancepositiveregulationofapoptoticprocessinanotherorganismpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofglucosetransmembranetransportpositiveregulationofimmuneresponsepositiveregulationoflipidstoragepositiveregulationofopsonizationpositiveregulationofphagocytosispositiveregulationofphagocytosisengulfmentpositiveregulationofproteinphosphorylationpositiveregulationofreceptor-mediatedendocytosispositiveregulationoftypeIIahypersensitivitypositiveregulationofvascularendothelialgrowthfactorproductionproteolysisregulationofcomplementactivationregulationofcomplementactivationalternativepathwayregulationoftriglyceridebiosyntheticprocessresponsetobacteriumsignaltransductionvertebrateeye-specificpatterning
Galactokinase
391
Galactokinase
391
2.0
57
0.86
GALK1GALK1P51570P51570galactitolmetabolicprocessgalactosecatabolicprocessgalactosecatabolicprocessviaUDP-galactosegalactosemetabolicprocessglycolyticprocessfromgalactose
Complement C4-A
876
Complement C4-A
1590
2.0
69
0.71
CO4ACO4AP0C0L4P0C0L4complementactivationcomplementactivationclassicalpathwayinflammatoryresponseinnateimmuneresponsepositiveregulationofapoptoticcellclearancepositiveregulationofimmuneresponsepositiveregulationofopsonization
Hairy/enhancer-of-split related with YRPW motif protein 1
130
Hairy/enhancer-of-split related with YRPW motif protein 1
130
2.0
78
0.63
HEY1HEY1Q9Y5J3Q9Y5J3angiogenesisanterior/posteriorpatternspecificationaorticvalvemorphogenesisarterialendothelialcelldifferentiationatrioventricularvalveformationcardiacconductionsystemdevelopmentcardiacepithelialtomesenchymaltransitioncardiacseptummorphogenesiscardiacventriclemorphogenesiscirculatorysystemdevelopmentdorsalaortamorphogenesisendocardialcushionmorphogenesishearttrabeculaformationlabyrinthinelayerbloodvesseldevelopmentnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofneurondifferentiationnegativeregulationofNotchsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedinsmoothmusclecelldifferentiationnegativeregulationoftranscriptionregulatoryregionDNAbindingnegativeregulationoftranscriptionDNA-templatedNotchsignalinginvolvedinheartdevelopmentNotchsignalingpathwaypositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIpulmonaryvalvemorphogenesisregulationofneurogenesisregulationoftranscriptionbyRNApolymeraseIIregulationofvasculogenesisumbilicalcordmorphogenesisventricularseptummorphogenesis
Integrin beta-2
33
Integrin beta-2
447
2.0
69
0.71
ITB2ITB2P05107P05107amyloid-betaclearanceapoptoticprocesscelladhesioncelladhesionmediatedbyintegrincellmigrationcell-celladhesioncell-celladhesionviaplasma-membraneadhesionmoleculescell-cellsignalingcell-matrixadhesioncellularresponsetolow-densitylipoproteinparticlestimulusendodermalcelldifferentiationheterotypiccell-celladhesioninflammatoryresponseintegrin-mediatedsignalingpathwayleukocytecell-celladhesionmicroglialcellactivationnegativeregulationofdopaminemetabolicprocessneutrophilchemotaxisneutrophilmigrationphagocytosisengulfmentpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofneurondeathpositiveregulationofneutrophildegranulationpositiveregulationofprostaglandin-Esynthaseactivitypositiveregulationofproteintargetingtomembranepositiveregulationofsuperoxideaniongenerationreceptorclusteringreceptorinternalizationreceptor-mediatedendocytosisregulationofcellshaperegulationofpeptidyl-tyrosinephosphorylation
Eukaryotic translation initiation factor 5A-1
129
Eukaryotic translation initiation factor 5A-1
129
2.0
44
1.12
IF5A1IF5A1P63241P63241cellularresponsetoviruspositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranslationalelongationpositiveregulationoftranslationalterminationtumornecrosisfactor-mediatedsignalingpathway
Insulin
91
Insulin
31
2.0
50
0.98
INSINSP01317P01317estradiolsecretionfeedingbehaviorglucoseimportinresponsetoinsulinstimulusglucosemetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofappetitenegativeregulationoflactationnegativeregulationoflipidcatabolicprocesspositiveregulationofbloodcirculationpositiveregulationofcellmaturationpositiveregulationofgeneexpressionpositiveregulationofinsulinsecretionpositiveregulationoflactationpositiveregulationofmammaryglandepithelialcellproliferationpositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinsecretionpositiveregulationofRhoproteinsignaltransductionproteinsecretionresponsetobutyrateresponsetofoodresponsetoglucoseresponsetogrowthhormoneresponsetoheatresponsetoL-arginineresponsetonutrientlevels
Trypsin
15
Trypsin
145
2.0
64
0.77
TRYPTRYPP00761P00761digestionproteolysis
Complement C4-A
567
Complement C4-A
820
2.0
73
0.67
CO4ACO4AP0C0L4P0C0L4complementactivationcomplementactivationclassicalpathwayinflammatoryresponseinnateimmuneresponsepositiveregulationofapoptoticcellclearancepositiveregulationofimmuneresponsepositiveregulationofopsonization
Laminin subunit beta-1
1785
Laminin subunit gamma-1
1598
2.0
45
1.09
LAMB1LAMC1P02469P02468animalorganmorphogenesisbasementmembraneassemblycellmigrationembryoimplantationlearningormemorynegativeregulationofcelladhesionneuronprojectiondevelopmentneuronal-glialinteractioninvolvedincerebralcortexradialgliaguidedmigrationodontogenesispositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofintegrin-mediatedsignalingpathwaypositiveregulationofmusclecelldifferentiationregulationofbasementmembraneorganizationsubstrateadhesion-dependentcellspreadingtissuedevelopmentcelladhesionchromatinorganizationextracellularmatrixdisassemblygeneexpressionhaircelldifferentiationhairfolliclecellproliferationhairfolliclemorphogenesishemidesmosomeassemblyprotein-containingcomplexassemblytissuemorphogenesis
Receptor-interacting serine/threonine-protein kinase 3
234
Receptor-interacting serine/threonine-protein kinase 3
234
2.0
57
0.86
RIPK3RIPK3Q9Y572Q9Y572activationofproteinkinaseactivityamyloidfibrilformationapoptoticsignalingpathwaycellularresponsetohydrogenperoxidedefenseresponsetovirusexecutionphaseofnecroptosisI-kappaBkinase/NF-kappaBsignalinglymphnodedevelopmentnecroptoticprocessnecroptoticsignalingpathwaypositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofligaseactivitypositiveregulationofnecroptoticprocesspositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofoxidoreductaseactivitypositiveregulationofphosphataseactivitypositiveregulationofreactiveoxygenspeciesmetabolicprocessprogrammednecroticcelldeathproteinautophosphorylationproteinmodificationprocessreactiveoxygenspeciesmetabolicprocessregulationofactivatedTcellproliferationregulationofactivation-inducedcelldeathofTcellsregulationofadaptiveimmuneresponseregulationofapoptoticprocessregulationofCD8-positivealpha-betacytotoxicTcellextravasationregulationofinterferon-gammaproductionregulationofTcellmediatedcytotoxicitysignaltransductionspleendevelopmentTcelldifferentiationinthymusTcellhomeostasisthymusdevelopment
Dopamine beta-hydroxylase
528
Dopamine beta-hydroxylase
530
2.0
33
1.49
DOPODOPOP09172P09172behavioralresponsetoethanolbloodvesselremodelingchemicalsynaptictransmissiondopaminecatabolicprocessfearresponseglucosehomeostasishomoiothermyleukocytemediatedimmunityleukocytemigrationlocomotorybehaviormaternalbehaviormemorynorepinephrinebiosyntheticprocessoctopaminebiosyntheticprocesspositiveregulationofcold-inducedthermogenesispositiveregulationofvasoconstrictionregulationofextrinsicapoptoticsignalingpathwayregulationofvascularassociatedsmoothmusclecellproliferationregulationofvascularendothelialcellproliferationresponsetoamphetamineresponsetopainvasoconstrictionvisuallearning
Prothrombin
339
Prothrombin
485
2.0
84
0.59
THRBTHRBP00735P00735acute-phaseresponseplateletactivationpositiveregulationofbloodcoagulationproteinpolymerizationproteolysis
Mucin-2
1130
Mucin-2
1130
2.0
53
0.93
MUC2MUC2Q02817Q02817maintenanceofgastrointestinalepithelium
Retinoic acid receptor RXR-alpha
269
Retinoic acid receptor RXR-alpha
269
2.0
55
0.9
RXRARXRAP19793P19793anatomicalstructuredevelopmentcelldifferentiationhormone-mediatedsignalingpathwaymRNAtranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionbyRNApolymeraseIIperoxisomeproliferatoractivatedreceptorsignalingpathwaypositiveregulationofbonemineralizationpositiveregulationofcholesteroleffluxpositiveregulationofthyroidhormonemediatedsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransporteractivitypositiveregulationofvitaminDreceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIresponsetoretinoicacidretinoicacidreceptorsignalingpathway
Bone morphogenetic protein 10
388
Bone morphogenetic protein 10
388
2.0
85
0.58
BMP10BMP10O95393O95393activinreceptorsignalingpathwayadultheartdevelopmentatrialcardiacmuscletissuemorphogenesisBMPsignalingpathwaycardiacmusclecellproliferationcelladhesionhearttrabeculaformationkidneydevelopmentnegativeregulationofcardiacmusclehypertrophynegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofendothelialcellmigrationpathway-restrictedSMADproteinphosphorylationpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcardiacmusclehypertrophypositiveregulationofcartilagedevelopmentpositiveregulationofcellproliferationinvolvedinheartmorphogenesispositiveregulationofgeneexpressionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofsarcomereorganizationpositiveregulationoftranscriptionDNA-templatedregulationofcardiacmusclecontractionregulationofcardiacmusclehypertrophyinresponsetostresssarcomereorganizationSMADproteinsignaltransductionventricularcardiacmusclecelldevelopmentventricularcardiacmuscletissuemorphogenesis
Filamin-C
1653
Filamin-C
1653
2.0
85
0.58
FLNCFLNCQ14315Q14315sarcomereorganization
Fibrinogen beta chain
227
Fibrinogen gamma chain
165
2.0
64
0.77
FIBBFIBGP02675P02679adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Protein AF-9
119
Protein AF-9
119
2.0
63
0.78
AF9AF9P42568P42568anterior/posteriorpatternspecificationchromatinremodelinggeneexpressionhematopoieticstemcelldifferentiationhistoneacetylationnegativeregulationofcanonicalWntsignalingpathwaypositiveregulationoftranscriptionDNA-templatedpositiveregulationofWntsignalingpathwayplanarcellpolaritypathwayregulationofchromatinorganizationregulationofstemcelldivisionregulationoftranscriptionbyRNApolymeraseIIsegmentspecification
Artemin
187
Artemin
187
2.0
72
0.68
ARTNARTNQ5T4W7Q5T4W7axonguidanceinductionofpositivechemotaxislymphocytemigrationintolymphoidorgansneuroblastproliferationperipheralnervoussystemdevelopment"Peyerspatchmorphogenesis"signaltransduction
Growth/differentiation factor 2
392
Growth/differentiation factor 2
392
2.0
87
0.57
GDF2GDF2Q9UK05Q9UK05activinreceptorsignalingpathwayangiogenesisbloodvesselmorphogenesisBMPsignalingpathwaybranchinginvolvedinbloodvesselmorphogenesiscartilagedevelopmentcellularironionhomeostasiscellularresponsetoBMPstimulusnegativeregulationofangiogenesisnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellgrowthnegativeregulationofDNAbiosyntheticprocessnegativeregulationofDNAreplicationnegativeregulationofendothelialcellmigrationnegativeregulationofendothelialcellproliferationossificationosteoblastdifferentiationpathway-restrictedSMADproteinphosphorylationpositiveregulationofangiogenesispositiveregulationofBMPsignalingpathwaypositiveregulationofcartilagedevelopmentpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofinterleukin-8productionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedSMADproteinsignaltransductiontranscriptionbyRNApolymeraseIIvasculogenesis
Vitamin K-dependent protein C
319
Vitamin K-dependent protein C
183
2.0
84
0.59
PROCPROCP04070P04070bloodcoagulationnegativeregulationofapoptoticprocessnegativeregulationofbloodcoagulationnegativeregulationofcoagulationnegativeregulationofinflammatoryresponsepositiveregulationofestablishmentofendothelialbarrierproteolysis
Chymotrypsinogen B
154
Chymotrypsinogen B
219
2.0
74
0.67
CTRB1CTRB1P07338P07338digestionpositiveregulationofapoptoticprocessproteincatabolicprocessproteolysisresponsetocytokineresponsetofoodresponsetonutrientresponsetopeptidehormoneresponsetotoxicsubstance
T-cell receptor, sp3.4 alpha chain
161
Human nkt tcr beta chain
176
2.0
68
0.72
K7N5N2K7N5M4K7N5N2K7N5M4
Activin receptor type-1
395
Activin receptor type-1
395
2.0
63
0.78
ACVR1ACVR1Q04771Q04771activinreceptorsignalingpathwayacuteinflammatoryresponseatrialseptumprimummorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwayBMPsignalingpathwayinvolvedinheartdevelopmentbranchinginvolvedinbloodvesselmorphogenesiscardiacmusclecellfatecommitmentcellularresponsetoBMPstimuluscellularresponsetoglucocorticoidstimuluscellularresponsetogrowthfactorstimulusdeterminationofleft/rightsymmetrydorsal/ventralpatternformationembryonichearttubemorphogenesisendocardialcushioncellfatecommitmentendocardialcushionfusionendocardialcushionmorphogenesisgastrulationwithmouthformingsecondgermcelldevelopmentheartdevelopmentinuteroembryonicdevelopmentmesodermformationmitralvalvemorphogenesisnegativeregulationofactivinreceptorsignalingpathwaynegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofsignaltransductionneuralcrestcellmigrationpathway-restrictedSMADproteinphosphorylationpeptidyl-threoninephosphorylationpharyngealsystemdevelopmentpositiveregulationofbonemineralizationpositiveregulationofcellmigrationpositiveregulationofdeterminationofdorsalidentitypositiveregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationpositiveregulationofosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedproteinphosphorylationregulationofossificationregulationofskeletalmuscletissuedevelopmentsmoothmusclecelldifferentiationtransforminggrowthfactorbetareceptorsignalingpathwayurogenitalsystemdevelopmentventricularseptummorphogenesis
Collagen alpha-1(III) chain
1285
Collagen alpha-1(III) chain
1268
2.0
68
0.72
CO3A1CO3A1P02461P02461aortasmoothmuscletissuemorphogenesisbasementmembraneorganizationcell-matrixadhesioncellularresponsetoaminoacidstimuluscerebralcortexdevelopmentchondrocytedifferentiationcollagenfibrilorganizationdigestivetractdevelopmentelasticfiberassemblyendochondralbonemorphogenesisextracellularmatrixorganizationfibroblastproliferationheartdevelopmentinuteroembryonicdevelopmentintegrin-mediatedsignalingpathwaylayerformationincerebralcortexlimbjointmorphogenesislungdevelopmentmulticellularorganismgrowthnegativeregulationofimmuneresponsenegativeregulationofneuronmigrationneuronmigrationpeptidecross-linkingplateletactivationpositiveregulationofRhoproteinsignaltransductionresponsetoangiotensinresponsetocytokineresponsetoradiationskindevelopmentsupramolecularfiberorganizationtissuehomeostasistransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbeta1productionwoundhealing
E3 ubiquitin-protein ligase RNF31
59
E3 ubiquitin-protein ligase RNF31
59
2.0
76
0.65
RNF31RNF31Q96EP0Q96EP0CD40signalingpathwaydefenseresponsetobacteriumnegativeregulationofnecroptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteintargetingtomitochondrionpositiveregulationofxenophagyproteinlinearpolyubiquitinationproteinpolyubiquitinationTcellreceptorsignalingpathway
Bone morphogenetic protein 2
360
Bone morphogenetic protein 2
360
2.0
86
0.57
BMP2BMP2P12643P12643ameloblastdifferentiationanimalorganmorphogenesisaorticvalvedevelopmentastrocytedifferentiationatrioventricularcanalmorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwayBMPsignalingpathwayinvolvedinheartdevelopmentBMPsignalingpathwayinvolvedinheartinductionbonemineralizationbonemineralizationinvolvedinbonematurationbranchinginvolvedinuretericbudmorphogenesiscardiacatriumformationcardiacepithelialtomesenchymaltransitioncardiacjellydevelopmentcardiacmusclecelldifferentiationcardiacmuscletissuemorphogenesiscardiocytedifferentiationcellfatecommitmentcell-cellsignalingcellularresponsetoBMPstimuluscellularresponsetoorganiccycliccompoundchondrocytedifferentiationcorticotropinhormonesecretingcelldifferentiationembryonichearttubeanterior/posteriorpatternspecificationendocardialcushionformationendocardialcushionmorphogenesisepithelialtomesenchymaltransitionheartdevelopmentinuteroembryonicdevelopmentinflammatoryresponseinnereardevelopmentmesenchymalcelldifferentiationmesenchymalcellproliferationinvolvedinuretericbuddevelopmentmesenchymedevelopmentnegativeregulationofaldosteronebiosyntheticprocessnegativeregulationofcalcium-independentcell-celladhesionnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcardiacmusclecelldifferentiationnegativeregulationofcellcyclenegativeregulationofcellpopulationproliferationnegativeregulationofcortisolbiosyntheticprocessnegativeregulationofgeneexpressionnegativeregulationofinsulin-likegrowthfactorreceptorsignalingpathwaynegativeregulationofMAPkinaseactivitynegativeregulationofsmoothmusclecellproliferationnegativeregulationofsteroidbiosyntheticprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofWntsignalingpathwayinvolvedinheartdevelopmentNotchsignalingpathwayodontogenesisofdentin-containingtoothosteoblastdifferentiationpathway-restrictedSMADproteinphosphorylationpericardiumdevelopmentpositiveregulationofapoptoticprocesspositiveregulationofastrocytedifferentiationpositiveregulationofbonemineralizationpositiveregulationofcartilagedevelopmentpositiveregulationofcellmigrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcelldifferentiationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixconstituentsecretionpositiveregulationoffatcelldifferentiationpositiveregulationofgeneexpressionpositiveregulationofMAPKcascadepositiveregulationofmiRNAtranscriptionpositiveregulationofneurondifferentiationpositiveregulationofodontogenesispositiveregulationofossificationpositiveregulationofosteoblastdifferentiationpositiveregulationofosteoblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofperoxisomeproliferatoractivatedreceptorsignalingpathwaypositiveregulationofphosphataseactivitypositiveregulationofproteinbindingpositiveregulationofproteinphosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimuluspositiveregulationoftranscriptionDNA-templatedpositiveregulationofWntsignalingpathwaypositiveregulationofWntsignalingpathwaybyBMPsignalingpathwayproteindestabilizationproteinphosphorylationproteoglycanmetabolicprocessregulationofodontogenesisofdentin-containingtoothregulationoftranscriptionDNA-templatedresponsetobacteriumresponsetohypoxiaskeletalsystemdevelopmentSMADproteinsignaltransductiontelencephalondevelopmenttelencephalonregionalizationthyroid-stimulatinghormone-secretingcelldifferentiationtranscriptionbyRNApolymeraseIIWntsignalingpathway
Insulin
97
Insulin
43
2.0
48
1.02
A6XGL2A6XGL2A6XGL2A6XGL2glucosemetabolicprocess
Liprin-alpha-2
113
Liprin-alpha-2
113
2.0
49
1.0
LIPA2LIPA2O75334O75334cell-matrixadhesiondensecoregranulecytoskeletaltransportregulationofdendriticspinedevelopmentregulationofdendriticspinemorphogenesissynapseorganization
Protein FAM3C
221
Protein FAM3C
64
2.0
60
0.82
FAM3CFAM3CQ91VU0Q91VU0negativeregulationofgluconeogenesis
Norrin
131
Norrin
131
2.0
62
0.79
NDPNDPQ00604Q00604decidualizationextracellularmatrix-cellsignalingnervoussystemdevelopmentNorrinsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoftranscriptionDNA-templatedretinavasculaturemorphogenesisincamera-typeeyevacuoleorganizationvisualperceptionWntsignalingpathway
Fibrinogen beta chain
227
Fibrinogen gamma chain
165
2.0
62
0.79
FIBBFIBGP02675Q53Y18adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Beta-hexosaminidase subunit beta
91
Beta-hexosaminidase subunit beta
137
2.0
62
0.79
HEXBHEXBP07686P07686astrocytecellmigrationcellularcalciumionhomeostasisgangliosidecatabolicprocessglycosaminoglycanmetabolicprocesslipidstoragelocomotorybehaviorlysosomeorganizationmaintenanceoflocationincellmalecourtshipbehaviormyelinationneuromuscularprocesscontrollingbalanceneuroncellularhomeostasisoligosaccharidecatabolicprocessoogenesispenetrationofzonapellucidaphospholipidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIproteinmetabolicprocessregulationofcellshapesensoryperceptionofsoundsinglefertilizationskeletalsystemdevelopment
Leukocyte immunoglobulin-like receptor subfamily A member 2
143
Leukocyte immunoglobulin-like receptor subfamily A member 2
195
2.0
85
0.58
LIRA2LIRA2Q8N149Q8N149cytokine-mediatedsignalingpathwaydefenseresponseinnateimmuneresponseinnateimmuneresponseactivatingcellsurfacereceptorsignalingpathwaynegativeregulationoflipopolysaccharide-mediatedsignalingpathwaynegativeregulationoftoll-likereceptor4signalingpathwayneutrophilactivationinvolvedinimmuneresponsepositiveregulationofcalciumiontransportpositiveregulationofcellactivationpositiveregulationofgranulocytecolony-stimulatingfactorproductionpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationoftumornecrosisfactorproductionsignaltransduction
Centrosomal protein of 135 kDa
110
Centrosomal protein of 135 kDa
110
2.0
49
1.0
CP135CP135Q66GS9Q66GS9centriolereplicationcentriole-centriolecohesionpositiveregulationofestablishmentofproteinlocalizationpositiveregulationofnon-motileciliumassembly
Complement C4-A
1394
Complement C4-A
1566
2.0
63
0.78
CO4ACO4AP0C0L4P0C0L4complementactivationcomplementactivationclassicalpathwayinflammatoryresponseinnateimmuneresponsepositiveregulationofapoptoticcellclearancepositiveregulationofimmuneresponsepositiveregulationofopsonization
Bone marrow stromal antigen 2
96
Bone marrow stromal antigen 2
96
2.0
53
0.93
BST2BST2Q8R2Q8Q8R2Q8defenseresponsetovirusinnateimmuneresponsenegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofintracellulartransportofviralmaterialnegativeregulationofplasmacytoiddendriticcellcytokineproductionnegativeregulationofviralgenomereplicationregulationofactincytoskeletonorganizationresponsetointerferon-alpharesponsetointerferon-betaresponsetointerferon-gammaresponsetovirus
Plexin-B2
1508
Plexin-B2
1510
2.0
39
1.26
PLXB2PLXB2B2RXS4B2RXS4braindevelopmentexcitatorysynapseassemblyhomophiliccelladhesionviaplasmamembraneadhesionmoleculesnegativeregulationofcelladhesionneuraltubeclosureneuroblastproliferationpositiveregulationofaxonogenesispositiveregulationofneuronprojectiondevelopmentpositiveregulationoftranslationregulationofcellmigrationregulationofcellshaperegulationofGTPaseactivityregulationofneuronmigrationregulationofproteinphosphorylationsemaphorin-plexinsignalingpathwaysemaphorin-plexinsignalingpathwayinvolvedinaxonguidance
Regulator of G-protein signaling 3
315
Regulator of G-protein signaling 3
314
2.0
74
0.66
RGS3RGS3P49796P49796Gprotein-coupledreceptorsignalingpathwaynegativeregulationofsignaltransductionregulationofGprotein-coupledreceptorsignalingpathwaysignaltransduction
Trypsin
124
Trypsin
191
2.0
64
0.77
TRYPTRYPP00761P00761digestionproteolysis
Interleukin-5
63
Interleukin-5
105
2.0
67
0.73
IL5IL5P05113P05113cytokine-mediatedsignalingpathwayimmuneresponseinflammatoryresponsepeptidyl-tyrosinephosphorylationpositiveregulationofBcellproliferationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofeosinophildifferentiationpositiveregulationofimmunoglobulinproductionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofpodosomeassemblypositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationoftranscriptionDNA-templated
cGMP-dependent protein kinase 1
43
cGMP-dependent protein kinase 1
43
2.0
45
1.09
1
✔KGP1KGP1Q13976Q13976actincytoskeletonorganizationcGMP-mediatedsignalingdendritedevelopmentforebraindevelopmentnegativeregulationofplateletaggregationnegativeregulationofvascularassociatedsmoothmusclecellmigrationnegativeregulationofvascularassociatedsmoothmusclecellproliferationneuronmigrationproteinphosphorylationregulationofGTPaseactivityrelaxationofvascularassociatedsmoothmusclesignaltransduction
Peroxiredoxin-2
172
Peroxiredoxin-2
51
2.0
57
0.86
1
✔PRDX2PRDX2P32119P32119cellredoxhomeostasiscellularresponsetooxidativestressdefenseresponsetotumorcellextrinsicapoptoticsignalingpathwayhydrogenperoxidecatabolicprocessleukocyteactivationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationoflipopolysaccharide-mediatedsignalingpathwaynegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofTcelldifferentiationpositiveregulationofbloodcoagulationpositiveregulationofMAPKcascaderegulationofapoptoticprocessregulationofhydrogenperoxidemetabolicprocessremovalofsuperoxideradicalsrespiratoryburstinvolvedininflammatoryresponseresponsetolipopolysaccharideresponsetooxidativestressTcellhomeostasisTcellproliferationthymusdevelopment
Protein PML
66
Protein PML
66
2.0
63
0.78
PMLPMLP29590P29590activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocessbranchinginvolvedinmammaryglandductmorphogenesiscellfatecommitmentcellularresponsetointerleukin-4cellularresponsetoleukemiainhibitoryfactorcellularsenescencecircadianregulationofgeneexpressioncommon-partnerSMADproteinphosphorylationDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestendoplasmicreticulumcalciumionhomeostasisentrainmentofcircadianclockbyphotoperiodextrinsicapoptoticsignalingpathwayfibroblastmigrationinnateimmuneresponseintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressintrinsicapoptoticsignalingpathwayinresponsetooxidativestressmaintenanceofproteinlocationinnucleusmyeloidcelldifferentiationnegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofinterleukin-1betaproductionnegativeregulationofmitoticcellcyclenegativeregulationoftelomeraseactivitynegativeregulationoftelomeremaintenanceviatelomerasenegativeregulationoftranscriptionDNA-templatednegativeregulationoftranslationinresponsetooxidativestressnegativeregulationofubiquitin-dependentproteincatabolicprocessoncogene-inducedcellsenescencePMLbodyorganizationpositiveregulationofapoptoticprocessinvolvedinmammaryglandinvolutionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationoffibroblastproliferationpositiveregulationofhistonedeacetylationpositiveregulationofpeptidyl-lysineacetylationpositiveregulationofproteinlocalizationtochromosometelomericregionpositiveregulationofsignaltransductionbyp53classmediatorpositiveregulationoftelomeremaintenancepositiveregulationoftranscriptionDNA-templatedproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinimportintonucleusproteinstabilizationproteintargetingprotein-containingcomplexassemblyprotein-containingcomplexlocalizationregulationofcalciumiontransportintocytosolregulationofcelladhesionregulationofcellcycleregulationofcircadianrhythmregulationofdouble-strandbreakrepairregulationoftranscriptionDNA-templatedresponsetocytokineresponsetogammaradiationresponsetohypoxiaresponsetoUVretinoicacidreceptorsignalingpathwaysuppressionofviralreleasebyhosttransforminggrowthfactorbetareceptorsignalingpathway
Trypsin-2
30
Trypsin-2
160
2.0
66
0.75
TRY2TRY2P07478P07478antimicrobialhumoralresponsecollagencatabolicprocessdigestionextracellularmatrixdisassemblypositiveregulationofcelladhesionpositiveregulationofcellgrowthproteolysis
Immunoglobulin kappa constant
107
Ig gamma-2A chain C region, membrane-bound form
14
2.0
nan
nan
IGKCGCAMP01837P01865adaptiveimmuneresponseBcelldifferentiationBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationantibody-dependentcellularcytotoxicityantigenprocessingandpresentationearlyendosometolateendosometransportendosometolysosometransporthumoralimmuneresponsemediatedbycirculatingimmunoglobulinimmunoglobulinmediatedimmuneresponsepositiveregulationofendocytosispositiveregulationofimmuneresponsepositiveregulationofphagocytosispositiveregulationoftypeIhypersensitivitypositiveregulationoftypeIIahypersensitivityregulationofproteolysis
Prostaglandin E synthase 3
58
Prostaglandin E synthase 3
58
2.0
86
0.57
TEBPTEBPQ15185Q15185chaperonecofactor-dependentproteinrefoldingchaperone-mediatedproteincomplexassemblycyclooxygenasepathwayfibroblastproliferationglucocorticoidreceptorsignalingpathwayglycogenbiosyntheticprocesslungsacculedevelopmentpositiveregulationofphosphorylationpositiveregulationoftelomeraseactivityprostaglandinbiosyntheticprocessproteinfoldingproteinstabilizationsignaltransductionskindevelopmenttelomeraseholoenzymecomplexassemblytelomeremaintenancetelomeremaintenanceviatelomerase
Interleukin-17F
137
Interleukin-17F
47
2.0
33
1.49
IL17FIL17FQ96PD4Q96PD4adaptiveimmuneresponsecartilagedevelopmentdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminflammatoryresponseinnateimmuneresponseinterleukin-17-mediatedsignalingpathwaynegativeregulationofangiogenesispositiveregulationofantimicrobialpeptideproductionpositiveregulationofchemokine(C-X-Cmotif)ligand1productionpositiveregulationofcytokineproductionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofinterleukin-6productionpositiveregulationoflymphotoxinAproductionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofgranulocytemacrophagecolony-stimulatingfactorproductionregulationofinterleukin-2productionregulationofinterleukin-6productionregulationofinterleukin-8productionregulationoftransforminggrowthfactorbetareceptorsignalingpathway
Vascular endothelial growth factor B
81
Vascular endothelial growth factor B
72
2.0
76
0.65
VEGFBVEGFBP49765P49765cardiacmusclecontractioncoronaryvasculaturedevelopmentinductionofpositivechemotaxisnegativeregulationofapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofneuronapoptoticprocesspositiveregulationofangiogenesispositiveregulationofcelldivisionpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofmastcellchemotaxispositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofvascularwoundhealingproteinO-linkedglycosylationresponsetohypoxiasproutingangiogenesisvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathway
Complement C5
810
Complement C5
567
2.0
70
0.7
CO5CO5P01031P01031cellsurfacereceptorsignalingpathwaychemotaxiscomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisGprotein-coupledreceptorsignalingpathwayinuteroembryonicdevelopmentinflammatoryresponsenegativeregulationofmacrophagechemotaxispositiveregulationofangiogenesispositiveregulationofchemokineproductionpositiveregulationofimmuneresponsepositiveregulationofvascularendothelialgrowthfactorproduction
Complement factor I
327
Complement factor I
453
2.0
72
0.68
CFAICFAIP05156P05156complementactivationclassicalpathwayinnateimmuneresponseproteolysisregulationofcomplementactivationalternativepathway
Transforming growth factor beta-1 proprotein
355
Transforming growth factor beta-1 proprotein
355
2.0
78
0.63
TGFB1TGFB1P07200P07200adaptiveimmuneresponsebasedonsomaticrecombinationofimmunereceptorsbuiltfromimmunoglobulinsuperfamilydomainsaorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaybranchelongationinvolvedinmammaryglandductbranchingbronchioledevelopmentcellmigrationcellmorphogenesiscell-celljunctionorganizationcellularcalciumionhomeostasiscellularresponsetoionizingradiationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetoviruschondrocytedifferentiationcolumnar/cuboidalepithelialcellmaturationcommon-partnerSMADproteinphosphorylationembryonicliverdevelopmentenamelmineralizationendodermdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialcellproliferationepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayfacemorphogenesisgeneexpressiongermcellmigrationhematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponseLangerhanscelldifferentiationlensfibercelldifferentiationlipopolysaccharide-mediatedsignalingpathwaylungalveolusdevelopmentlymphnodedevelopmentmammaryglandbranchinginvolvedinthelarcheMAPKcascademembraneproteinintracellulardomainproteolysismusclecellcellularhomeostasisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofepithelialcellproliferationnegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofinterleukin-17productionnegativeregulationofmacrophagecytokineproductionnegativeregulationofmyoblastdifferentiationnegativeregulationofossificationnegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationofTcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedneuraltubeclosureNotchsignalingpathwayoligodendrocytedevelopmentossificationinvolvedinboneremodelingosteoclastdifferentiationpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocessphospholipidhomeostasispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofhistoneacetylationpositiveregulationofhistonedeacetylationpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofodontogenesispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorclusteringpositiveregulationofregulatoryTcelldifferentiationpositiveregulationofSMADproteinsignaltransductionpositiveregulationofstemcellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofactincytoskeletonreorganizationregulationofbindingregulationofbranchinginvolvedinmammaryglandductmorphogenesisregulationofcartilagedevelopmentregulationofcellpopulationproliferationregulationofDNAbindingregulationofinterleukin-23productionregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofsodiumiontransportregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulatoryTcelldifferentiationresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductionstemcellproliferationsurfactanthomeostasisTcellhomeostasisTcellproliferationtoleranceinductiontoselfantigentransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmenturetericbuddevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
Acyloxyacyl hydrolase
123
Acyloxyacyl hydrolase
453
2.0
69
0.71
AOAHAOAHP28039P28039fattyacidmetabolicprocesslipopolysaccharidecatabolicprocessnegativeregulationofinflammatoryresponse
Fibrinogen beta chain
110
Fibrinogen gamma chain
45
2.0
80
0.61
FIBBFIBGP02675P02679adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
MAb 106 heavy chain
148
MAb 110 light chain
239
2.0
nan
nan
A0A0F7R1P3A0A0F7R5U8A0A0F7R1P3A0A0F7R5U8
Beta-hexosaminidase subunit alpha
58
Beta-hexosaminidase subunit alpha
104
2.0
66
0.74
HEXAHEXAP06865P06865adultwalkingbehaviorcarbohydratemetabolicprocesscellmorphogenesisinvolvedinneurondifferentiationgangliosidecatabolicprocessglycosaminoglycanbiosyntheticprocessglycosaminoglycanmetabolicprocesslipidstoragelysosomeorganizationmaintenanceoflocationincellmyelinationneuromuscularprocesscontrollingbalanceneuromuscularprocesscontrollingposturesensoryperceptionofsoundsexualreproductionskeletalsystemdevelopmentSMADproteinsignaltransduction
Thioredoxin
73
Thioredoxin
62
2.0
68
0.72
THIOTHIOP10599P10599activationofproteinkinaseBactivitycellredoxhomeostasisnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiation
SUMO-conjugating enzyme UBC9
138
Ran GTPase-activating protein 1
575
2.0
78
0.63
UBC9RAGP1P63279P46061celldivisionchromosomesegregationmitoticnuclearmembranereassemblynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednuclearexportpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofSUMOtransferaseactivityproteinmodificationprocessproteinsumoylationubiquitin-dependentproteincatabolicprocessactivationofGTPaseactivitycellularresponsetopeptidehormonestimuluscellularresponsetovasopressinnegativeregulationofproteinexportfromnucleusnucleocytoplasmictransportresponsetoaxoninjurysignaltransduction
Protein timeless homolog
1038
Protein timeless homolog
1038
2.0
56
0.88
TIMTIMQ9UNS1Q9UNS1branchingmorphogenesisofanepithelialtubecellcyclephasetransitioncelldivisioncellularresponsetobleomycincellularresponsetocisplatincellularresponsetoDNAdamagestimuluscellularresponsetohydroxyureacircadianrhythmdetectionofabioticstimulusDNArepairDNAreplicationcheckpointsignalinglungdevelopmentmorphogenesisofanepitheliumnegativeregulationoftranscriptionDNA-templatedpositiveregulationofdouble-strandbreakrepairpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationregulationofcircadianrhythmreplicationforkarrestreplicationforkprotection
Trypsin
117
Trypsin
218
2.0
59
0.83
TRYPTRYPP00761P00761digestionproteolysis
Coagulation factor IX
178
Coagulation factor IX
335
2.0
85
0.58
FA9FA9P00740P00740bloodcoagulationbloodcoagulationintrinsicpathwayproteolysiszymogenactivation
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
235
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
235
2.0
51
0.96
GCNT1GCNT1Q09324Q09324celladhesionmoleculeproductionglycoproteinbiosyntheticprocesskidneymorphogenesisleukocytetetheringorrollingO-glycanprocessingcore2positiveregulationofleukocytetetheringorrollingresponsetoinsulintissuemorphogenesis
Protein Aster-A
419
Protein Aster-A
419
2.0
45
1.09
ASTRAASTRAQ8VEF1Q8VEF1autophagycellularresponsetocholesterolintracellularsteroltransport
NACHT, LRR and PYD domains-containing protein 9
612
NACHT, LRR and PYD domains-containing protein 9
296
2.0
79
0.62
NLRP9NLRP9Q288C4Q288C4inflammatoryresponseinnateimmuneresponse
Protein KIBRA
771
Protein KIBRA
771
2.0
71
0.69
KIBRAKIBRAQ8IX03Q8IX03cellmigrationestablishmentofcellpolaritynegativeregulationofhipposignalingnegativeregulationoforgangrowthnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofMAPKcascaderegulationofhipposignalingregulationofintracellulartransportregulationoftranscriptionDNA-templated
Bone morphogenetic protein 6
477
Bone morphogenetic protein 6
477
2.0
84
0.59
BMP6BMP6P22004P22004BMPsignalingpathwaycartilagedevelopmentcellularironionhomeostasiscellularresponsetoBMPstimuluscellularresponsetoironioncellularresponsetomechanicalstimulusendochondralossificationeyedevelopmentimmuneresponseinflammatoryresponsekidneydevelopmentmalegenitaliadevelopmentmulticellularorganismalironionhomeostasisnegativeregulationofadherensjunctionorganizationnegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationoftranscriptionbyRNApolymeraseIIneurondifferentiationosteoblastdifferentiationpositiveregulationofaldosteronebiosyntheticprocesspositiveregulationofaldosteronesecretionpositiveregulationofbonemineralizationpositiveregulationofcellpopulationproliferationpositiveregulationofchondrocytedifferentiationpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofgeneexpressionpositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofneurondifferentiationpositiveregulationofosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinsecretionpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularpermeabilityresponsetoactivityresponsetoglucocorticoidresponsetomagnesiumionresponsetoretinoicacidskeletalsystemdevelopmentSMADproteinsignaltransductiontypeBpancreaticcelldevelopment
Lysine-specific demethylase 4B
165
Lysine-specific demethylase 4B
165
2.0
68
0.72
KDM4BKDM4BO94953O94953braindevelopmentchromatinremodelinghistoneH3-K36demethylationhistoneH3-K9demethylation
Glucocorticoid receptor
431
Glucocorticoid receptor
431
2.0
79
0.62
GCRGCRP04150P04150adrenalglanddevelopmentapoptoticprocesscellcyclecelldivisioncellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinorganizationchromosomesegregationglucocorticoidmetabolicprocessintracellularsteroidhormonereceptorsignalingpathwaymammaryglandductmorphogenesismaternalbehaviornegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedsignaltransduction
Transforming growth factor beta-3 proprotein
377
Transforming growth factor beta-3 proprotein
377
2.0
91
0.54
TGFB3TGFB3P10600P10600agingBMPsignalingpathwaycell-celljunctionorganizationdetectionofhypoxiadigestivetractdevelopmentembryonicneurocraniummorphogenesisfacemorphogenesisfemalepregnancyfrontalsuturemorphogenesisinuteroembryonicdevelopmentinnereardevelopmentlungalveolusdevelopmentmammaryglanddevelopmentnegativeregulationofcellpopulationproliferationnegativeregulationofmacrophagecytokineproductionnegativeregulationofneuronapoptoticprocessnegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofvascularassociatedsmoothmusclecellproliferationodontogenesisossificationinvolvedinboneremodelingpositiveregulationofapoptoticprocesspositiveregulationofbonemineralizationpositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationoffilopodiumassemblypositiveregulationofMAPKcascadepositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofSMADproteinsignaltransductionpositiveregulationofstressfiberassemblypositiveregulationoftightjunctiondisassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofcellpopulationproliferationresponsetoestrogenresponsetohypoxiaresponsetolaminarfluidshearstressresponsetoprogesteronesalivaryglandmorphogenesissecondarypalatedevelopmentSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwayuterinewallbreakdownwoundhealing
Medulloblastoma antigen MU-MB-50.72
96
Medulloblastoma antigen MU-MB-50.72
100
2.0
60
0.82
Q7Z5E2Q7Z5E2Q7Z5E2Q7Z5E2
Mannan-binding lectin serine protease 1
436
Mannan-binding lectin serine protease 1
572
2.0
86
0.57
MASP1MASP1P48740P48740cellsurfacepatternrecognitionreceptorsignalingpathwaycomplementactivationlectinpathwaynegativeregulationofcomplementactivationpositiveregulationofopsonizationproteolysis
Complement C4-A
876
Complement C4-B
1590
2.0
76
0.65
CO4ACO4BP0C0L4P0C0L5complementactivationcomplementactivationclassicalpathwayinflammatoryresponseinnateimmuneresponsepositiveregulationofapoptoticcellclearancepositiveregulationofimmuneresponsepositiveregulationofopsonizationdetectionofmoleculeofbacterialoriginopsonization
Transforming growth factor beta-1 proprotein
355
Transforming growth factor beta-1 proprotein
355
2.0
87
0.57
TGFB1TGFB1P01137P01137aorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaycellmigrationcell-celljunctionorganizationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluschondrocytedifferentiationcommon-partnerSMADproteinphosphorylationconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingembryonicliverdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayheartdevelopmentheartvalvemorphogenesishematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphnodedevelopmentmacrophagederivedfoamcelldifferentiationMAPKcascademembraneproteinintracellulardomainproteolysisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofcytolysisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixdisassemblynegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofmacrophagecytokineproductionnegativeregulationofmiRNAmaturationnegativeregulationofmiRNAtranscriptionnegativeregulationofmiRNA-mediatedgenesilencingnegativeregulationofmyoblastdifferentiationnegativeregulationofproteinlocalizationtoplasmamembranenegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationoftranscriptionDNA-templatedneuraltubeclosureneuraltubedevelopmentossificationinvolvedinboneremodelingpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixassemblypositiveregulationoffibroblastmigrationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationofSMADproteinsignaltransductionpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularpermeabilityproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofbindingregulationofbloodvesselremodelingregulationofcellmigrationregulationofcellpopulationproliferationregulationofDNAbindingregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
Prothrombin
333
Prothrombin
479
2.0
81
0.61
THRBTHRBP19221P19221acute-phaseresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidebloodcoagulationbloodcoagulationcommonpathwaycellsurfacereceptorsignalingpathwaycytolysisbyhostofsymbiontcellsfibrinolysisnegativeregulationofastrocytedifferentiationnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationofproteolysisneutrophil-mediatedkillingofgram-negativebacteriumplateletactivationpositiveregulationofbloodcoagulationpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationoflipidkinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinphosphorylationpositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofreleaseofsequesteredcalciumionintocytosolproteolysisregulationofcellshaperegulationofcytosoliccalciumionconcentrationregulationofgeneexpressionresponsetowoundingthrombin-activatedreceptorsignalingpathwayzymogenactivation
Mannan-binding lectin serine protease 2
434
Mannan-binding lectin serine protease 2
552
2.0
73
0.67
MASP2MASP2O00187O00187cellsurfacepatternrecognitionreceptorsignalingpathwaycomplementactivationclassicalpathwaycomplementactivationlectinpathwaypositiveregulationofopsonizationproteolysis
Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant
841
Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant
841
2.0
52
0.95
Q59FF6Q59FF6Q59FF6Q59FF6
Protein FosB
172
Transcription factor JunD
285
2.0
58
0.85
FOSBJUNDP53539P17535cellularresponsetocalciumioncellularresponsetohormonestimulusfemalepregnancynegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIresponsetocAMPresponsetocorticosteroneresponsetomechanicalstimulusresponsetomorphineresponsetoprogesteroneresponsetoxenobioticstimulustranscriptionbyRNApolymeraseIIagingcellularresponsetohypoxiacircadianrhythmosteoblastdevelopmentpositiveregulationofmacrophageactivationpositiveregulationofosteoblastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellcycleregulationofcellpopulationproliferationresponsetolightstimulusresponsetolipopolysaccharideresponsetoorganiccycliccompoundresponsetopeptidehormone
Transforming growth factor beta-1 proprotein
225
Transforming growth factor beta-1 proprotein
223
2.0
61
0.81
TGFB1TGFB1P01137P01137aorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaycellmigrationcell-celljunctionorganizationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluschondrocytedifferentiationcommon-partnerSMADproteinphosphorylationconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingembryonicliverdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayheartdevelopmentheartvalvemorphogenesishematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphnodedevelopmentmacrophagederivedfoamcelldifferentiationMAPKcascademembraneproteinintracellulardomainproteolysisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofcytolysisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixdisassemblynegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofmacrophagecytokineproductionnegativeregulationofmiRNAmaturationnegativeregulationofmiRNAtranscriptionnegativeregulationofmiRNA-mediatedgenesilencingnegativeregulationofmyoblastdifferentiationnegativeregulationofproteinlocalizationtoplasmamembranenegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationoftranscriptionDNA-templatedneuraltubeclosureneuraltubedevelopmentossificationinvolvedinboneremodelingpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixassemblypositiveregulationoffibroblastmigrationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationofSMADproteinsignaltransductionpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularpermeabilityproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofbindingregulationofbloodvesselremodelingregulationofcellmigrationregulationofcellpopulationproliferationregulationofDNAbindingregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesis
Ubiquitin carboxyl-terminal hydrolase 7
315
Ubiquitin carboxyl-terminal hydrolase 7
315
2.0
53
0.93
UBP7UBP7Q93009Q93009histoneH2BconservedC-terminallysinedeubiquitinationmaintenanceofDNAmethylationmonoubiquitinatedproteindeubiquitinationnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofDNAdemethylationproteindeubiquitinationproteinK63-linkeddeubiquitinationproteinstabilizationproteinubiquitinationregulationofcircadianrhythmregulationofDNA-bindingtranscriptionfactoractivityregulationofgluconeogenesisregulationofproteinstabilityregulationofretrogradetransportendosometoGolgiregulationofsignaltransductionbyp53classmediatorregulationoftelomerecappingrhythmicprocesstranscription-couplednucleotide-excisionrepairubiquitin-dependentproteincatabolicprocess
Nuclear receptor ROR-gamma
393
Nuclear receptor ROR-gamma
393
2.0
66
0.75
RORGRORGP51449P51449adiposetissuedevelopmentcellularresponsetosterolcircadianregulationofgeneexpressionlymphnodedevelopmentnegativeregulationofthymocyteapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseII"Peyerspatchdevelopment"positiveregulationofcircadianrhythmpositiveregulationoftranscriptionDNA-templatedregulationoffatcelldifferentiationregulationofglucosemetabolicprocessregulationofsteroidmetabolicprocessregulationoftranscriptionbyRNApolymeraseIIT-helper17celldifferentiationT-helpercelldifferentiationxenobioticmetabolicprocess
Vesicle-associated membrane protein-associated protein A
60
Vesicle-associated membrane protein-associated protein A
60
2.0
78
0.63
VAPAVAPAQ9P0L0Q9P0L0celldeathceramidetransportCOPII-coatedvesiclebuddingendoplasmicreticulumtoGolgivesicle-mediatedtransportmembranefusionnegativeregulationbyhostofviralgenomereplicationneuronprojectiondevelopmentphospholipidtransportpositiveregulationbyhostofviralgenomereplicationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingproteinlocalizationtoendoplasmicreticulumsphingomyelinbiosyntheticprocesssteroltransportviralreleasefromhostcell
Immunoglobulin heavy constant epsilon
121
Immunoglobulin heavy constant epsilon
209
2.0
69
0.71
IGHEIGHEP01854P01854adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Fibrinogen beta chain
87
Fibrinogen gamma-B chain
43
2.0
76
0.65
FIBBFIBGP02676P12799adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioninnateimmuneresponseplateletaggregationproteinpolymerization
Transcription regulator protein BACH2
20
Transcription regulator protein BACH2
20
2.0
72
0.68
BACH2BACH2Q9BYV9Q9BYV9importintonucleusnegativeregulationoftranscriptionbyRNApolymeraseIIprimaryadaptiveimmuneresponseinvolvingTcellsandBcellsregulationoftranscriptionbyRNApolymeraseII
Cathepsin B
105
Cathepsin B
150
2.0
71
0.69
CATBCATBP07688P07688cellularresponsetothyroidhormonestimuluscollagencatabolicprocessdecidualizationepithelialcelldifferentiationnegativeregulationofpeptidaseactivityproteolysisinvolvedinproteincatabolicprocessthyroidhormonegenerationviralentryintohostcell
Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7
47
Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7
47
2.0
81
0.61
JMJD7JMJD7P0C870P0C870proteinhydroxylationproteolysis
Spindle and kinetochore-associated protein 3
20
Spindle and kinetochore-associated protein 3
20
2.0
64
0.77
SKA3SKA3Q8IX90Q8IX90celldivisionchromosomesegregationmitoticcellcycleregulationofmicrotubulepolymerizationordepolymerization
IGL@ protein
234
IGL@ protein
234
2.0
29
1.7
Q6PIK1Q6PIK1Q6PIK1Q6PIK1
Synaptonemal complex protein 1
703
Synaptonemal complex protein 1
703
2.0
61
0.81
SYCP1SYCP1Q15431Q15431celldivisionchiasmaassemblyhomologouschromosomepairingatmeiosislateralelementassemblymeioticDNArepairsynthesisproteinhomotetramerizationreciprocalmeioticrecombinationregulationofproteinlocalizationspermDNAcondensationspermatogenesissynaptonemalcomplexassembly
Glutathione reductase, mitochondrial
134
Glutathione reductase, mitochondrial
134
2.0
58
0.85
GSHRGSHRP00390P00390cellredoxhomeostasiscellularresponsetooxidativestressglutathionemetabolicprocess
Cathepsin B
105
Cathepsin B
150
2.0
72
0.68
CATBCATBP07858P07858cellularresponsetothyroidhormonestimuluscollagencatabolicprocessdecidualizationepithelialcelldifferentiationnegativeregulationofpeptidaseactivityproteolysisproteolysisinvolvedinproteincatabolicprocessregulationofapoptoticprocessthyroidhormonegenerationviralentryintohostcell
Ras-related protein Rab-5C
64
Ras-related protein Rab-5C
64
2.0
58
0.85
RAB5CRAB5CP51148P51148endocytosisintracellularproteintransportplasmamembranetoendosometransportregulationofendocytosis
Dual specificity protein phosphatase 26
59
Dual specificity protein phosphatase 26
59
2.0
53
0.93
DUS26DUS26Q9BV47Q9BV47negativeregulationofERK1andERK2cascadenegativeregulationofMAPKcascadenegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcelladhesionproteindephosphorylation
Glandular kallikrein
14
Glandular kallikrein
158
2.0
66
0.75
KLKKLKP00752P00752regulationofsystemicarterialbloodpressurezymogenactivation
Tyrosyl-DNA phosphodiesterase 2
137
Tyrosyl-DNA phosphodiesterase 2
137
2.0
61
0.81
TYDP2TYDP2Q9JJX7Q9JJX7double-strandbreakrepairneurondevelopment
Growth/differentiation factor 8
339
Growth/differentiation factor 8
339
2.0
77
0.64
GDF8GDF8O14793O14793cellularresponsetodexamethasonestimulusmusclecellcellularhomeostasismuscleorgandevelopmentmyoblastmigrationinvolvedinskeletalmuscleregenerationnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofkinaseactivitynegativeregulationofmusclehypertrophynegativeregulationofmyoblastdifferentiationnegativeregulationofmyoblastproliferationnegativeregulationofproteinkinaseBsignalingnegativeregulationofsatellitecelldifferentiationnegativeregulationofskeletalmusclesatellitecellproliferationnegativeregulationofskeletalmuscletissuegrowthovulationcycleprocesspositiveregulationoflamellipodiumassemblypositiveregulationofmacrophagechemotaxispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionDNA-templatedresponsetoelectricalstimulusresponsetoestrogenresponsetoethanolresponsetogravityresponsetoheatresponsetomuscleactivityresponsetotestosteroneskeletalmuscleatrophySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
DNA-(apurinic or apyrimidinic site) endonuclease
138
DNA-(apurinic or apyrimidinic site) endonuclease
138
2.0
58
0.85
APEX1APEX1P27695P27695agingbase-excisionrepairbase-excisionrepairgap-fillingcellredoxhomeostasiscellularresponsetocAMPcellularresponsetohydrogenperoxidecellularresponsetopeptidehormonestimulusDNAcatabolicprocessendonucleolyticDNAdemethylationDNArecombinationDNArepairnegativeregulationofsmoothmusclecellmigrationpositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofapoptoticprocessregulationofmRNAstabilityresponsetoxenobioticstimulustelomeremaintenancetelomeremaintenanceviabase-excisionrepair
Transforming acidic coiled-coil-containing protein 3
828
Transforming acidic coiled-coil-containing protein 3
828
2.0
72
0.68
TACC3TACC3Q9Y6A5Q9Y6A5celldivisioncellpopulationproliferationcerebralcortexdevelopmentmetaphase/anaphasetransitionofmitoticcellcyclemicrotubulecytoskeletonorganizationmicrotubulecytoskeletonorganizationinvolvedinmitosismitoticspindleorganizationregulationofmitoticspindleorganization
Platelet-derived growth factor subunit A
123
Platelet-derived growth factor subunit A
132
2.0
73
0.68
PDGFAPDGFAP04085P04085actincytoskeletonorganizationangiogenesisanimalorganmorphogenesiscellactivationcellprojectionassemblycell-cellsignalingcellularresponsetotransforminggrowthfactorbetastimulusembryoniclungdevelopmenthairfollicledevelopmentinnereardevelopmentlungalveolusdevelopmentmalegonaddevelopmentnegativechemotaxisnegativeregulationofphosphatidylinositolbiosyntheticprocessnegativeregulationofplateletactivationplatelet-derivedgrowthfactorreceptorsignalingpathwayplatelet-derivedgrowthfactorreceptor-alphasignalingpathwaypositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmesenchymalcellproliferationpositiveregulationofmetanephricmesenchymalcellmigrationbyplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingregulationofactincytoskeletonorganizationregulationofbranchinginvolvedinsalivaryglandmorphogenesisbyepithelial-mesenchymalsignalingregulationofpeptidyl-tyrosinephosphorylationregulationofsmoothmusclecellmigrationresponsetoestradiolresponsetohypoxiaresponsetoinorganicsubstanceresponsetoretinoicacidresponsetowoundingresponsetoxenobioticstimulusskindevelopmentwoundhealing
Ubiquitin carboxyl-terminal hydrolase 5
195
Ubiquitin carboxyl-terminal hydrolase 5
195
2.0
56
0.88
UBP5UBP5P45974P45974positiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteindeubiquitinationproteinK48-linkeddeubiquitinationproteinubiquitinationubiquitin-dependentproteincatabolicprocess
PDZ and LIM domain protein 4
72
PDZ and LIM domain protein 4
72
2.0
67
0.74
PDLI4PDLI4P50479P50479actincytoskeletonorganizationactincytoskeletonreorganizationexcitatorychemicalsynaptictransmissionheartdevelopmentmusclestructuredevelopment
Bone marrow stromal antigen 2
68
Bone marrow stromal antigen 2
68
2.0
50
0.99
BST2BST2Q8R2Q8Q8R2Q8defenseresponsetovirusinnateimmuneresponsenegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofintracellulartransportofviralmaterialnegativeregulationofplasmacytoiddendriticcellcytokineproductionnegativeregulationofviralgenomereplicationregulationofactincytoskeletonorganizationresponsetointerferon-alpharesponsetointerferon-betaresponsetointerferon-gammaresponsetovirus
Actin, alpha skeletal muscle
376
Actin, alpha skeletal muscle
376
2.0
53
0.93
ACTSACTSP68135P68135actinfilamentbundleassemblyactinfilamentpolymerizationmesenchymemigrationpositiveregulationofgeneexpressionskeletalmusclefiberdevelopmentskeletalmusclethinfilamentassembly
Kinesin-like protein KIF20A
607
Kinesin-like protein KIF20A
607
2.0
46
1.07
KI20AKI20AO95235O95235microtubulebundleformationmicrotubule-basedmovementmidbodyabscissionmitoticcytokinesisproteintransportregulationofcytokinesis
Complement C4-A
1394
Complement C4-B
1566
2.0
56
0.88
CO4ACO4BP0C0L4P0C0L5complementactivationcomplementactivationclassicalpathwayinflammatoryresponseinnateimmuneresponsepositiveregulationofapoptoticcellclearancepositiveregulationofimmuneresponsepositiveregulationofopsonizationdetectionofmoleculeofbacterialoriginopsonization
Growth/differentiation factor 5
465
Growth/differentiation factor 5
465
2.0
90
0.55
GDF5GDF5P43026P43026BMPsignalingpathwaycell-cellsignalingchondroblastdifferentiationchondrocytedifferentiationembryoniclimbmorphogenesisforelimbmorphogenesishindlimbmorphogenesismesenchymalcellapoptoticprocessnegativeregulationofchondrocytedifferentiationnegativeregulationofepithelialcellproliferationnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofneuronapoptoticprocessossificationinvolvedinboneremodelingpositiveregulationofBMPsignalingpathwaypositiveregulationofchondrocytedifferentiationpositiveregulationofneurondifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationregulationofmulticellularorganismgrowthregulationofSMADproteinsignaltransductionresponsetomechanicalstimulusSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Vascular endothelial growth factor C
165
Vascular endothelial growth factor C
156
2.0
82
0.6
VEGFCVEGFCP49767P49767animalorganmorphogenesiscellularresponsetoleukemiainhibitoryfactorglialcellproliferationinductionofpositivechemotaxismorphogenesisofembryonicepitheliumnegativeregulationofbloodpressurenegativeregulationofosteoblastdifferentiationpositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellproliferationpositiveregulationofglialcellproliferationpositiveregulationoflymphangiogenesispositiveregulationofmastcellchemotaxispositiveregulationofmesenchymalstemcellproliferationpositiveregulationofneuroblastproliferationpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayresponsetohypoxiaresponsetoxenobioticstimulussignaltransductionsproutingangiogenesissubstrate-dependentcellmigrationvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathway
Thioredoxin
35
Thioredoxin
73
2.0
70
0.7
THIOTHIOP10599P10599activationofproteinkinaseBactivitycellredoxhomeostasisnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiation
Nucleoprotein TPR
75
Nucleoprotein TPR
75
2.0
53
0.93
TPRTPRP12270P12270celldivisioncellularresponsetoheatcellularresponsetointerferon-alphamitoticspindleassemblycheckpointsignalingmRNAexportfromnucleusmRNAexportfromnucleusinresponsetoheatstressnegativeregulationofRNAexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranslationalinitiationnuclearporeorganizationnucleocytoplasmictransportpositiveregulationofheterochromatinassemblypositiveregulationofintracellularproteintransportpositiveregulationofmitoticcellcyclespindleassemblycheckpointpositiveregulationofproteinexportfromnucleuspositiveregulationofproteinimportintonucleusproteinimportintonucleusregulationofmitoticsisterchromatidseparationregulationofmitoticspindleassemblyregulationofproteinlocalizationresponsetoepidermalgrowthfactorRNAexportfromnucleusRNAimportintonucleus
Mitogen-activated protein kinase 14
119
Mitogen-activated protein kinase 14
119
2.0
55
0.9
MK14MK14Q16539Q16539"3-UTR-mediatedmRNAstabilization"angiogenesisapoptoticprocessbonedevelopmentcartilagecondensationcellmorphogenesiscellsurfacereceptorsignalingpathwaycellularresponsetoionizingradiationcellularresponsetolipopolysaccharidecellularresponsetolipoteichoicacidcellularresponsetotumornecrosisfactorcellularresponsetovascularendothelialgrowthfactorstimuluscellularresponsetoviruscellularsenescencechemotaxischondrocytedifferentiationDNAdamagecheckpointsignalingfattyacidoxidationglucoseimportglucosemetabolicprocessintracellularsignaltransductionlipopolysaccharide-mediatedsignalingpathwaynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofhipposignalingnegativeregulationofinflammatoryresponsetoantigenicstimulusosteoblastdifferentiationosteoclastdifferentiationp38MAPKcascadepeptidyl-serinephosphorylationplacentadevelopmentplateletactivationpositiveregulationofbrownfatcelldifferentiationpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcyclaseactivitypositiveregulationoferythrocytedifferentiationpositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofinterleukin-12productionpositiveregulationofmusclecelldifferentiationpositiveregulationofmyoblastdifferentiationpositiveregulationofmyoblastfusionpositiveregulationofmyotubedifferentiationpositiveregulationofproteinimportintonucleuspositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcytokineproductioninvolvedininflammatoryresponseregulationofossificationregulationofsynapticmembraneadhesionregulationoftranscriptionbyRNApolymeraseIIresponsetodietaryexcessresponsetoinsulinresponsetomuramyldipeptideresponsetomusclestretchsignaltransductionsignaltransductioninresponsetoDNAdamageskeletalmuscletissuedevelopmentstemcelldifferentiationstress-inducedprematuresenescencestriatedmusclecelldifferentiationtranscriptionbyRNApolymeraseIItransmembranereceptorproteinserine/threoninekinasesignalingpathwayvascularendothelialgrowthfactorreceptorsignalingpathway
Talin-1
575
Talin-1
575
2.0
81
0.61
TLN1TLN1P26039P26039cell-celladhesioncell-substratejunctionassemblycorticalactincytoskeletonorganizationintegrinactivationintegrin-mediatedsignalingpathway
Peroxiredoxin-4
245
Endoplasmic reticulum resident protein 44
58
2.0
78
0.63
PRDX4ERP44Q13162Q9BS26cellredoxhomeostasisextracellularmatrixorganizationI-kappaBphosphorylationmalegonaddevelopmentnegativeregulationofmalegermcellproliferationpeptidyl-prolinehydroxylationto4-hydroxy-L-prolineproteinmaturationbyproteinfoldingreactiveoxygenspeciesmetabolicprocessresponsetooxidativestressspermatogenesisglycoproteinmetabolicprocessproteinfoldingresponsetoendoplasmicreticulumstressresponsetounfoldedprotein
cDNA FLJ56409, highly similar to Serine/threonine-protein kinase Chk1
424
cDNA FLJ56409, highly similar to Serine/threonine-protein kinase Chk1
424
2.0
45
1.1
B4DT73B4DT73B4DT73B4DT73proteinphosphorylation
HECT-type E3 ubiquitin transferase
4169
HECT-type E3 ubiquitin transferase
4169
2.0
56
0.88
A0A024R9Y3A0A024R9Y3A0A024R9Y3A0A024R9Y3DNArepair
Transcription intermediary factor 1-alpha
917
Transcription intermediary factor 1-alpha
917
2.0
55
0.9
TIF1ATIF1AO15164O15164calciumionhomeostasiscellularresponsetoestrogenstimulusepithelialcellproliferationnegativeregulationofepithelialcellproliferationnegativeregulationoftranscriptionDNA-templatedpositiveregulationofgeneexpressionproteinautophosphorylationproteincatabolicprocessproteinubiquitinationregulationofapoptoticprocessregulationofproteinstabilityregulationofsignaltransductionbyp53classmediatorregulationofvitaminDreceptorsignalingpathwaytranscriptionbyRNApolymeraseII
PRKCA-binding protein
46
PRKCA-binding protein
46
2.0
88
0.56
Q6GQQ2Q6GQQ2Q6GQQ2Q6GQQ2monoaminetransportphosphorylationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayregulationofinsulinsecretion
Dipeptidase 1
377
Dipeptidase 1
377
2.0
56
0.88
DPEP1DPEP1P16444P16444antibioticmetabolicprocesscellularlactamcatabolicprocesscellularresponsetocalciumioncellularresponsetonitricoxidecellularresponsetoxenobioticstimulusglutathionecatabolicprocessglutathionemetabolicprocesshomocysteinemetabolicprocessleukotrieneD4catabolicprocesslipidmetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofcellmigrationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessproteolysis
Golgi-associated PDZ and coiled-coil motif-containing protein
327
Golgi-associated PDZ and coiled-coil motif-containing protein
327
2.0
59
0.84
GOPCGOPCQ9HD26Q9HD26apicalproteinlocalizationcytoplasmicsequesteringofCFTRproteinendoplasmicreticulumtoGolgivesicle-mediatedtransportGolgitoplasmamembranetransportnegativeregulationofanionchannelactivitynegativeregulationofproteinlocalizationtocellsurfaceproteintransport
Protein mono-ADP-ribosyltransferase PARP14
1618
Protein mono-ADP-ribosyltransferase PARP14
1618
2.0
69
0.72
PAR14PAR14Q460N5Q460N5innateimmuneresponsenegativeregulationofgeneexpressionnegativeregulationofinterferon-gamma-mediatedsignalingpathwaynegativeregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofinterleukin-4-mediatedsignalingpathwaypositiveregulationoftyrosinephosphorylationofSTATproteinproteinADP-ribosylationproteinmono-ADP-ribosylationproteinpoly-ADP-ribosylation
Platelet-derived growth factor subunit B
133
Platelet-derived growth factor subunit B
124
2.0
67
0.74
PDGFBPDGFBP01127P01127activationofproteinkinaseactivityactivationofproteinkinaseBactivitycellchemotaxiscellularresponsetogrowthfactorstimuluscellularresponsetomycophenolicacidcellularresponsetoplatelet-derivedgrowthfactorstimulusembryonicplacentadevelopmentheartdevelopmentinterleukin-18-mediatedsignalingpathwaymetanephricglomerularmesangialcelldevelopmentmonocytechemotaxisnegativeregulationofgeneexpressionnegativeregulationofmiRNAtranscriptionnegativeregulationofphosphatidylinositolbiosyntheticprocessnegativeregulationofplateletactivationnegativeregulationofproteinbindingnegativeregulationoftranscriptionDNA-templatednegativeregulationofvascularassociatedsmoothmusclecelldifferentiationparacrinesignalingpeptidyl-serinephosphorylationpeptidyl-tyrosinephosphorylationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcalciumionimportpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-substrateadhesionpositiveregulationofchemotaxispositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglomerularfiltrationpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofhyaluronanbiosyntheticprocesspositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmetanephricmesenchymalcellmigrationpositiveregulationofmetanephricmesenchymalcellmigrationbyplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofmiRNAtranscriptionpositiveregulationofmitoticnucleardivisionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularassociatedsmoothmusclecelldedifferentiationpositiveregulationofvascularassociatedsmoothmusclecellmigrationpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseCsignalingproteinphosphorylationreactiveoxygenspeciesmetabolicprocessresponsetowounding
BTB/POZ domain-containing protein KCTD8
238
BTB/POZ domain-containing protein KCTD8
238
2.0
94
0.52
KCTD8KCTD8Q6ZWB6Q6ZWB6proteinhomooligomerizationregulationofGprotein-coupledreceptorsignalingpathway
Inhibin beta A chain
390
Inhibin beta A chain
390
2.0
63
0.79
INHBAINHBAP08476P08476activinreceptorsignalingpathwaycelldifferentiationcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularresponsetocholesterolcellularresponsetofollicle-stimulatinghormonestimulusdefenseresponseendodermalcelldifferentiationerythrocytedifferentiationextrinsicapoptoticsignalingpathwayeyeliddevelopmentincamera-typeeyeGABAergicneurondifferentiationhairfollicledevelopmenthematopoieticprogenitorcelldifferentiationhemoglobinbiosyntheticprocessmalegonaddevelopmentmesodermalcelldifferentiationmulticellularorganismagingnegativeregulationofBcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationoffollicle-stimulatinghormonesecretionnegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofinterferon-gammaproductionnegativeregulationofmacrophagedifferentiationnegativeregulationofphosphorylationnervoussystemdevelopmentodontogenesisovarianfollicledevelopmentpositiveregulationoferythrocytedifferentiationpositiveregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandpositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofgeneexpressionpositiveregulationofovulationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprogesteronesecretionregulationoffollicle-stimulatinghormonesecretionregulationoftranscriptionbyRNApolymeraseIIresponsetoxenobioticstimulusroofofmouthdevelopmentSMADproteinsignaltransductionstriatalmediumspinyneurondifferentiationtranscriptionbyRNApolymeraseII
Repulsive guidance molecule B
163
Repulsive guidance molecule B
312
2.0
80
0.62
RGMBRGMBQ6NW40Q6NW40BMPsignalingpathwaycelladhesionpositiveregulationoftranscriptionDNA-templatedsignaltransduction
Dystrophin
433
Dystrophin
433
2.0
61
0.82
DMDDMDP11532P11532actincytoskeletonorganizationcardiacmusclecellactionpotentialcardiacmusclecontractionmaintenanceofblood-brainbarriermotileciliumassemblymusclecellcellularhomeostasismusclecelldevelopmentmuscleorgandevelopmentnegativeregulationofpeptidyl-cysteineS-nitrosylationnegativeregulationofpeptidyl-serinephosphorylationneurondevelopmentpeptidebiosyntheticprocesspositiveregulationofneurondifferentiationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofsodiumiontransmembranetransporteractivityproteinlocalizationprotein-containingcomplexassemblyregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofcellularresponsetogrowthfactorstimulusregulationofheartrateregulationofmusclesystemprocessregulationofreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumregulationofryanodine-sensitivecalcium-releasechannelactivityregulationofskeletalmusclecontractionregulationofskeletalmusclecontractionbyregulationofreleaseofsequesteredcalciumionregulationofvoltage-gatedcalciumchannelactivityresponsetomusclestretchskeletalmuscletissuedevelopment
Prorelaxin H2
185
Prorelaxin H2
47
2.0
nan
nan
REL2REL2P04090P04090femalepregnancypositiveregulationofangiogenesispositiveregulationofgeneexpressionregulationofcatalyticactivity
PRKCA-binding protein
46
PRKCA-binding protein
44
2.0
68
0.74
PICK1PICK1Q9NRD5Q9NRD5cellularresponsetodecreasedoxygenlevelscellularresponsetoglucosestarvationdendriticspinemaintenancedendriticspineorganizationDNAmethylationinvolvedinembryodevelopmentDNAmethylationinvolvedingametegenerationglialcelldevelopmentintracellularproteintransportlong-termsynapticdepressionmonoaminetransportnegativeregulationofArp2/3complex-mediatedactinnucleationneuronalionchannelclusteringpositiveregulationofreceptorinternalizationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteinphosphorylationreceptorclusteringregulationofArp2/3complex-mediatedactinnucleationregulationofinsulinsecretionretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulum
Voltage-gated hydrogen channel 1
249
Voltage-gated hydrogen channel 1
249
2.0
55
0.91
HVCN1HVCN1Q96D96Q96D96cellredoxhomeostasiscellularresponsetopHcellularresponsetozincionpositiveregulationofsuperoxideaniongenerationprotontransmembranetransportregulationofintracellularpHregulationofiontransmembranetransportresponsetopHresponsetozincion
Kelch-like protein 3
526
Kelch-like protein 3
549
2.0
85
0.59
KLHL3KLHL3Q9UH77Q9UH77distaltubulemorphogenesisgeneexpressionionhomeostasispotassiumionhomeostasisproteinK48-linkedubiquitinationproteinphosphorylationproteinubiquitinationrenalsodiumionabsorptionselectiveautophagyubiquitin-dependentproteincatabolicprocess
Fibrinogen alpha chain
184
Fibrinogen gamma chain
161
2.0
72
0.69
FIBAFIBGP02671P02679adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-1cellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
PRKCA-binding protein
44
PRKCA-binding protein
44
2.0
80
0.62
Q6GQQ2Q6GQQ2Q6GQQ2Q6GQQ2monoaminetransportphosphorylationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayregulationofinsulinsecretion
Macrophage colony-stimulating factor 1
63
Macrophage colony-stimulating factor 1
63
2.0
56
0.89
CSF1CSF1Q3U395Q3U395branchinginvolvedinmammaryglandductmorphogenesiscellpopulationproliferationdevelopmentalprocessinvolvedinreproductionhomeostasisofnumberofcellswithinatissueinflammatoryresponseinnateimmuneresponsemacrophagecolony-stimulatingfactorsignalingpathwaymacrophagedifferentiationmacrophagehomeostasismammaryductterminalendbudgrowthmammaryglandfatdevelopmentmicroglialcellproliferationmonocytedifferentiationmonocytehomeostasismyeloidleukocytemigrationnegativeregulationofneurondeathneutrophilhomeostasisodontogenesisossificationosteoclastdifferentiationosteoclastproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-matrixadhesionpositiveregulationofgeneexpressionpositiveregulationofleukocytemigrationpositiveregulationofmacrophagechemotaxispositiveregulationofmacrophagecolony-stimulatingfactorsignalingpathwaypositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofmacrophagedifferentiationpositiveregulationofmacrophagemigrationpositiveregulationofmicroglialcellmigrationpositiveregulationofmonocytedifferentiationpositiveregulationofmononuclearcellproliferationpositiveregulationofmulticellularorganismgrowthpositiveregulationofodontogenesisofdentin-containingtoothpositiveregulationofosteoclastdifferentiationpositiveregulationofproteinkinaseactivitypositiveregulationofproteinmetabolicprocesspositiveregulationofRasproteinsignaltransductionRasproteinsignaltransductionregulationofossificationresponsetoischemiatransmembranereceptorproteintyrosinekinasesignalingpathway
Tyrosine-protein phosphatase non-receptor type 4
590
Tyrosine-protein phosphatase non-receptor type 4
590
1.9
73
0.7
PTN4PTN4P29074P29074peptidyl-tyrosinephosphorylationproteindephosphorylation
Immunoglobulin heavy constant alpha 1
180
Immunoglobulin heavy constant alpha 1
180
2.0
52
0.95
IGHA1IGHA1P01876P01876adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
Ighg protein
155
MAb 6H10 light chain
234
2.0
nan
nan
Q569X1A0A0U5BC76Q569X1A0A0U5BC76
Hemoglobin subunit beta
113
Hemoglobin subunit beta
113
2.0
88
0.56
HBBHBBP68871P68871carbondioxidetransportcellularoxidantdetoxificationhydrogenperoxidecatabolicprocessnitricoxidetransportoxygentransportplateletaggregationpositiveregulationofcelldeathpositiveregulationofnitricoxidebiosyntheticprocessregulationofbloodpressurerenalabsorptionresponsetohydrogenperoxide
Xenotropic and polytropic retrovirus receptor 1
188
Xenotropic and polytropic retrovirus receptor 1
188
2.0
64
0.77
XPR1XPR1Q9UBH6Q9UBH6cellularphosphateionhomeostasiscellularresponsetophosphatestarvationGprotein-coupledreceptorsignalingpathwayphosphateiontransmembranetransportphosphateiontransportresponsetovirus
Neurturin
164
Neurturin
164
2.0
75
0.66
NRTNNRTNQ99748Q99748MAPKcascadenervedevelopmentnervoussystemdevelopmentneuralcrestcellmigrationneuronprojectiondevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathway
CCA tRNA nucleotidyltransferase 1, mitochondrial
373
CCA tRNA nucleotidyltransferase 1, mitochondrial
373
2.0
71
0.7
TRNT1TRNT1Q96Q11Q96Q11ATPCTPCTP"mitochondrialtRNA3-endprocessing""tRNA3-endprocessing""tRNA3-terminalCCAaddition"tRNAprocessing
Fibrinogen alpha chain
64
Fibrinogen gamma chain
49
2.0
84
0.59
FIBAFIBGP02671P02679adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-1cellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Guanine nucleotide-binding protein G(i) subunit alpha-1
214
Guanine nucleotide-binding protein G(i) subunit alpha-1
214
2.0
51
0.97
GNAI1GNAI1P10824P10824adenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaynegativeregulationofsynaptictransmissionpositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganization
Tumor necrosis factor receptor superfamily member 9
121
Tumor necrosis factor receptor superfamily member 9
121
2.0
72
0.69
TNR9TNR9Q07011Q07011apoptoticprocessnegativeregulationofcellpopulationproliferationregulationofcellpopulationproliferationregulationofimmatureTcellproliferationinthymus
Sialoadhesin
36
Sialoadhesin
36
2.0
75
0.66
SNSNQ62230Q62230celladhesionclathrin-dependentendocytosisofvirusbyhostcellpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofTcellapoptoticprocess
Immunoglobulin lambda-1 light chain
215
Immunoglobulin lambda-1 light chain
215
2.0
35
1.41
IGL1IGL1P0DOX8P0DOX8adaptiveimmuneresponse
DEP domain-containing mTOR-interacting protein
102
DEP domain-containing mTOR-interacting protein
102
2.0
44
1.12
DPTORDPTORQ8TB45Q8TB45intracellularsignaltransductionnegativeregulationofcellsizenegativeregulationofproteinkinaseactivitynegativeregulationofTORsignalingnegativeregulationofTORC1signalingnegativeregulationofTORC2signalingregulationofextrinsicapoptoticsignalingpathway
Interleukin-5
104
Interleukin-5
62
2.0
68
0.73
IL5IL5P04401P04401cytokine-mediatedsignalingpathwayimmuneresponseinflammatoryresponsepeptidyl-tyrosinephosphorylationpositiveregulationofBcellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofeosinophildifferentiationpositiveregulationofimmunoglobulinproductionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofpodosomeassemblypositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationoftranscriptionDNA-templated
Beta-2-microglobulin
100
Beta-2-microglobulin
45
2.0
77
0.65
B2MGB2MGP61769P61769amyloidfibrilformationantibacterialhumoralresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofexogenousproteinantigenviaMHCclassIbTAP-dependentantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetoironioncellularresponsetoiron(III)ioncellularresponsetolipopolysaccharidecellularresponsetonicotinedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseironionhomeostasisironiontransportlearningormemorynegativeregulationofepithelialcellproliferationnegativeregulationofforebrainneurondifferentiationnegativeregulationofneurogenesisnegativeregulationofneuronprojectiondevelopmentnegativeregulationofreceptorbindingpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofcellularsenescencepositiveregulationofferrousironbindingpositiveregulationofproteinbindingpositiveregulationofreceptorbindingpositiveregulationofreceptor-mediatedendocytosispositiveregulationofTcellactivationpositiveregulationofTcellcytokineproductionpositiveregulationofTcellmediatedcytotoxicitypositiveregulationoftransferrinreceptorbindingproteinhomotetramerizationproteinrefoldingregulationoferythrocytedifferentiationregulationofironiontransportregulationofmembranedepolarizationresponsetomoleculeofbacterialoriginretinahomeostasissensoryperceptionofsmellTcelldifferentiationinthymusTcellmediatedcytotoxicity
Protein polybromo-1
450
Protein polybromo-1
450
2.0
66
0.76
PB1PB1Q86U86Q86U86chromatinremodelingmitoticcellcyclenegativeregulationofcellpopulationproliferationpositiveregulationofcelldifferentiationpositiveregulationofdouble-strandbreakrepairpositiveregulationofmyoblastdifferentiationpositiveregulationofTcelldifferentiationregulationofG0toG1transitionregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofnucleotide-excisionrepairregulationoftranscriptionbyRNApolymeraseII
Myeloperoxidase
319
Myeloperoxidase
319
2.0
61
0.82
PERMPERMP05164P05164agingdefenseresponsedefenseresponsetobacteriumdefenseresponsetofungushydrogenperoxidecatabolicprocesshypochlorousacidbiosyntheticprocesslow-densitylipoproteinparticleremodelingnegativeregulationofapoptoticprocessremovalofsuperoxideradicalsrespiratoryburstinvolvedindefenseresponseresponsetofoodresponsetogoldnanoparticleresponsetolipopolysaccharideresponsetomechanicalstimulusresponsetooxidativestressresponsetoyeast
Coagulation factor X
341
Coagulation factor X
172
2.0
82
0.6
FA10FA10P00743P00743bloodcoagulationproteolysis
Sodium channel subunit beta-4
58
Sodium channel subunit beta-4
58
2.0
40
1.24
SCN4BSCN4BQ7M729Q7M729AVnodecellactionpotentialcardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractionestablishmentoflocalizationincellmembranedepolarizationduringcardiacmusclecellactionpotentialpositiveregulationofsodiumiontransportregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityregulationofventricularcardiacmusclecellmembranerepolarizationsodiumiontransmembranetransportsodiumiontransport
Cyclin-G-associated kinase
87
Cyclin-G-associated kinase
87
2.0
70
0.71
GAKGAKO14976O14976cellcyclechaperonecofactor-dependentproteinrefoldingclathrincoatdisassemblyclathrin-coatedpitassemblyclathrin-dependentendocytosisendoplasmicreticulumorganizationGolgiorganizationGolgitolysosometransportnegativeregulationofneuronprojectiondevelopmentproteinlocalizationtoGolgiapparatusproteinlocalizationtoplasmamembraneproteinphosphorylationreceptor-mediatedendocytosissynapticvesicleuncoating
Noelin
221
Noelin
221
2.0
56
0.88
NOE1NOE1O88998O88998atrioventricularvalveformationcardiacepithelialtomesenchymaltransitionnegativeregulationofgeneexpressionnervoussystemdevelopmentneuronalsignaltransductionpositiveregulationofapoptoticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofgeneexpressionregulationofaxonextensionsignaltransduction
Cytohesin-3
342
Cytohesin-3
342
2.0
77
0.64
CYH3CYH3O08967O08967establishmentofepithelialcellpolarityGolgivesicletransportpositiveregulationofcelladhesionregulationofARFproteinsignaltransduction
Granzyme A
105
Granzyme A
105
2.0
54
0.91
GRAAGRAAP12544P12544apoptoticprocesscytolysiscytotoxicTcellpyroptoticprocessgranzyme-mediatedprogrammedcelldeathsignalingpathwayimmuneresponsenegativeregulationofDNAbindingnegativeregulationofendodeoxyribonucleaseactivitynegativeregulationofoxidoreductaseactivitypositiveregulationofapoptoticprocessproteolysisinvolvedinproteincatabolicprocesspyroptosisresponsetobacterium
Bone marrow stromal antigen 2
91
Bone marrow stromal antigen 2
91
2.0
49
1.0
BST2BST2Q10589Q10589BcellactivationdefenseresponsetovirusinnateimmuneresponsenegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofintracellulartransportofviralmaterialnegativeregulationofplasmacytoiddendriticcellcytokineproductionnegativeregulationofviralgenomereplicationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofleukocyteproliferationregulationofactincytoskeletonorganizationresponsetointerferon-alpharesponsetointerferon-betaresponsetointerferon-gammaresponsetovirus
Protein S100-A10
62
Protein S100-A10
62
2.0
42
1.18
S10AAS10AAP60903P60903membraneraftassemblymRNAtranscriptionbyRNApolymeraseIIpositiveregulationofbindingpositiveregulationofexocytosispositiveregulationoffocaladhesionassemblypositiveregulationofGTPaseactivitypositiveregulationofplasmamembranerepairpositiveregulationofplasminogenactivationpositiveregulationofstressfiberassemblypositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationtoplasmamembraneregulationofneurogenesisvesiclebuddingfrommembrane
Immunoglobulin kappa constant
107
Ig heavy chain Mem5
135
2.0
nan
nan
IGKCHVM63P01837P84751adaptiveimmuneresponseBcelldifferentiationBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
U2 small nuclear ribonucleoprotein A'
77
U2 small nuclear ribonucleoprotein A'
77
2.0
79
0.63
RU2ARU2AP09661P09661mRNAsplicingviaspliceosomeRNAsplicingspermatogenesisU2-typeprespliceosomeassembly
Thymocyte nuclear protein 1
118
Thymocyte nuclear protein 1
118
2.0
48
1.02
THYN1THYN1Q9P016Q9P016
Insulin receptor
551
Insulin receptor
551
2.0
74
0.67
INSRINSRP06213P06213activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearancecarbohydratemetabolicprocesscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaylearningmalegonaddevelopmentmalesexdeterminationmemoryneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationoftranscriptionDNA-templatedtransmembranereceptorproteintyrosinekinasesignalingpathwaytransportacrossblood-brainbarrierviralentryintohostcell
APOBEC3H
73
APOBEC3H
73
2.0
68
0.72
B7TQM8B7TQM8B7TQM8B7TQM8
Nucleotide-binding oligomerization domain-containing protein 1
39
Nucleotide-binding oligomerization domain-containing protein 1
39
2.0
74
0.66
NOD1NOD1Q9Y239Q9Y239activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocesscellularresponsetomuramyldipeptidedefenseresponsedefenseresponsetobacteriumdefenseresponsetoGram-positivebacteriumdetectionofbacteriumdetectionofbioticstimulusERK1andERK2cascadeI-kappaBkinase/NF-kappaBsignalinginflammatoryresponseinnateimmuneresponseintracellularsignaltransductionJNKcascadepatternrecognitionreceptorsignalingpathwaypositiveregulationofcelldeathpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofdendriticcellantigenprocessingandpresentationpositiveregulationofERK1andERK2cascadepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofJNKcascadepositiveregulationofmacrophagecytokineproductionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationoftumornecrosisfactorproductionpositiveregulationofxenophagyregulationofapoptoticprocesssignaltransductionxenophagy
Gamma-crystallin S
25
Gamma-crystallin S
25
2.0
67
0.73
CRYGSCRYGSP22914P22914lensdevelopmentincamera-typeeyemorphogenesisofanepitheliumvisualperception
Fibrinogen gamma-B chain
32
Fibrinogen gamma-B chain
33
2.0
50
0.98
FIBGFIBGP12799P12799bloodcoagulationfibrinclotformationcell-matrixadhesionplateletaggregationproteinpolymerization
Recombining binding protein suppressor of hairless
100
Mastermind-like protein 1
63
2.0
76
0.65
SUHMAML1Q06330Q92585angiogenesisaorticvalvedevelopmentarterialendothelialcellfatecommitmentatrioventricularcanaldevelopmentauditoryreceptorcellfatecommitmentBcelldifferentiationbloodvesselendothelialcellfatespecificationbloodvessellumenizationbloodvesselremodelingcardiacleftventriclemorphogenesiscardiacmusclecellmyoblastdifferentiationclubcelldifferentiationdefenseresponsetobacteriumdorsalaortamorphogenesisendocardiummorphogenesisepidermalcellfatespecificationepithelialcellproliferationepithelialtomesenchymaltransitionepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationhairfolliclematurationhumoralimmuneresponseinflammatoryresponsetoantigenicstimuluskeratinocytedifferentiationlabyrinthinelayerbloodvesseldevelopmentmyeloiddendriticcelldifferentiationnegativeregulationofcelldifferentiationnegativeregulationofcold-inducedthermogenesisnegativeregulationofossificationnegativeregulationofstemcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedNotchsignalinginvolvedinheartdevelopmentNotchsignalingpathwayoutflowtractmorphogenesispituitaryglanddevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofcanonicalWntsignalingpathwayinvolvedincardiacmusclecellfatecommitmentpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellproliferationinvolvedinheartmorphogenesispositiveregulationofephrinreceptorsignalingpathwaypositiveregulationofepithelialcellproliferationpositiveregulationofERBBsignalingpathwaypositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionofNotchreceptortargetpulmonaryvalvedevelopmentregulationofreproductiveprocessregulationoftimingofcelldifferentiationregulationoftranscriptionbyRNApolymeraseIIsebaceousglanddevelopmentsecondaryheartfieldspecificationsomaticstemcellpopulationmaintenancesomitogenesisstemcellproliferationventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesisatrioventricularnodecelldevelopmentatrioventricularnodedevelopmentmyoblastdifferentiationpositiveregulationofmyotubedifferentiationproteinphosphorylation
Voltage-gated hydrogen channel 1
245
Voltage-gated hydrogen channel 1
245
2.0
55
0.92
HVCN1HVCN1Q3U2S8Q3U2S8cellularresponsetopHcellularresponsetozincionpositiveregulationofsuperoxideaniongenerationprotontransmembranetransportregulationofintracellularpHregulationofiontransmembranetransportresponsetopHresponsetozincion
Serine protease hepsin
153
Serine protease hepsin
277
2.0
87
0.58
HEPSHEPSP05981P05981basementmembranedisassemblycochleamorphogenesisdetectionofmechanicalstimulusinvolvedinsensoryperceptionofsoundnegativeregulationofapoptoticprocessnegativeregulationofepithelialcellproliferationnegativeregulationofepithelialtomesenchymaltransitionpilomotorreflexpositiveregulationbyhostofviraltranscriptionpositiveregulationofcellgrowthpositiveregulationofgeneexpressionpositiveregulationofhepatocyteproliferationpositiveregulationofplasminogenactivationpositiveregulationofthyroidhormonegenerationpotassiumiontransmembranetransportproteolysisregulationofcellshaperesponsetothyroidhormone
Regulation of nuclear pre-mRNA domain-containing protein 1B
100
Regulation of nuclear pre-mRNA domain-containing protein 1B
100
2.0
62
0.81
RPR1BRPR1BQ9NQG5Q9NQG5dephosphorylationofRNApolymeraseIIC-terminaldomain"mRNA3-endprocessing"positiveregulationofcellpopulationproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellcycleprocess
Sorting nexin-11
55
Sorting nexin-11
138
2.0
79
0.64
SNX11SNX11Q9Y5W9Q9Y5W9intracellularproteintransportvesicleorganization
Piwi-like protein 1
577
Piwi-like protein 1
577
2.0
59
0.85
PIWL1PIWL1Q9JMB7Q9JMB7genesilencingbyRNAmeioticcellcyclenegativeregulationoftranspositionpiRNAmetabolicprocessregulationoftranslationspermatiddevelopmentspermatogenesisspermatogenesisexchangeofchromosomalproteins
LIM domain kinase 2
549
LIM domain kinase 2
365
2.0
55
0.9
LIMK2LIMK2P53671P53671actincytoskeletonorganizationastralmicrotubuleorganizationcorneadevelopmentincamera-typeeyeestablishmentofvesiclelocalizationheaddevelopmentnegativeregulationofciliumassemblyphosphorylationpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinphosphorylationproteinphosphorylationspermatogenesis
Double-strand break repair protein MRE11
146
Double-strand break repair protein MRE11
146
2.0
65
0.76
MRE11MRE11P49959P49959cellpopulationproliferationcellularresponsetoDNAdamagestimulusDNAdouble-strandbreakprocessingDNAduplexunwindingDNArecombinationDNArepairDNAstrandresectioninvolvedinreplicationforkprocessingdouble-strandbreakrepairdouble-strandbreakrepairviahomologousrecombinationdouble-strandbreakrepairvianonhomologousendjoininghomologouschromosomepairingatmeiosishomologousrecombinationmeioticDNAdouble-strandbreakformationmitochondrialdouble-strandbreakrepairviahomologousrecombinationmitoticG2DNAdamagecheckpointsignalingmitoticG2/Mtransitioncheckpointmitoticintra-SDNAdamagecheckpointsignalingnegativeregulationofapoptoticprocesspositiveregulationofkinaseactivitypositiveregulationofproteinautophosphorylationpositiveregulationoftelomeremaintenancereciprocalmeioticrecombinationregulationofmitoticrecombinationsisterchromatidcohesiontelomeremaintenancetelomeremaintenanceviatelomerase"telomeric3overhangformation"
DNA primase large subunit
449
DNA primase large subunit
449
2.0
83
0.6
PRI2PRI2P49643P49643DNAreplicationinitiationDNAreplicationsynthesisofRNAprimerpositiveregulationofDNAprimaseactivity
Neuropilin-2
434
Neuropilin-2
434
2.0
50
0.99
NRP2NRP2O60462O60462angiogenesisaxonextensioninvolvedinaxonguidanceaxonguidancecelladhesioncellularresponsetoleukemiainhibitoryfactordorsalrootganglionmorphogenesisfacialnervestructuralorganizationfacioacousticgangliondevelopmentgonadotrophin-releasinghormoneneuronalmigrationtothehypothalamusnegativechemotaxisnervedevelopmentneuralcrestcellmigrationinvolvedinautonomicnervoussystemdevelopmentoutflowtractseptummorphogenesispositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationregulationofpostsynapseorganizationsemaphorin-plexinsignalingpathwayinvolvedinneuronprojectionguidancesensoryneuronaxonguidancesympatheticgangliondevelopmentsympatheticneuronprojectionextensionsympatheticneuronprojectionguidancetrigeminalgangliondevelopmentventraltrunkneuralcrestcellmigrationvestibulocochlearnervestructuralorganization
E3 ubiquitin-protein ligase XIAP
351
E3 ubiquitin-protein ligase XIAP
351
2.0
45
1.1
XIAPXIAPP98170P98170cellularresponsetoDNAdamagestimuluscopperionhomeostasisinhibitionofcysteine-typeendopeptidaseactivityinhibitionofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationoftumornecrosisfactor-mediatedsignalingpathwayneuronapoptoticprocesspositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofJNKcascadepositiveregulationofproteinlinearpolyubiquitinationpositiveregulationofproteinubiquitinationregulationofapoptosisinvolvedintissuehomeostasisregulationofapoptoticprocessregulationofBMPsignalingpathwayregulationofcellcycleregulationofcellpopulationproliferationregulationofinflammatoryresponseregulationofinnateimmuneresponseregulationofnucleotide-bindingoligomerizationdomaincontainingsignalingpathwayWntsignalingpathway
Peroxiredoxin-4
245
Peroxiredoxin-4
124
2.2
nan
nan
1
✔PRDX4PRDX4Q13162Q13162cellredoxhomeostasisextracellularmatrixorganizationI-kappaBphosphorylationmalegonaddevelopmentnegativeregulationofmalegermcellproliferationpeptidyl-prolinehydroxylationto4-hydroxy-L-prolineproteinmaturationbyproteinfoldingreactiveoxygenspeciesmetabolicprocessresponsetooxidativestressspermatogenesis
Chymotrypsinogen A
1
Chymotrypsinogen A
122
2.1
nan
nan
CTRACTRAP00766P00766digestionproteolysis
Epididymis luminal protein 214
243
Uncharacterized protein
236
2.1
nan
nan
V9HW68Q7Z3Y4V9HW68Q7Z3Y4
Cartilage oligomeric matrix protein
71
Cartilage oligomeric matrix protein
68
2.0
52
0.95
COMPCOMPP35444P35444apoptoticprocessarterymorphogenesisbloodcoagulationBMPsignalingpathwaybonegrowthbonemineralizationbonemorphogenesiscartilagedevelopmentcartilagehomeostasischondrocytedevelopmentchondrocyteproliferationcollagenfibrilorganizationendochondralbonegrowthgrowthplatecartilagedevelopmentlimbdevelopmentmulticellularorganismagingmulticellularorganismgrowthmusclecelldevelopmentmusculoskeletalmovementnegativeregulationofapoptoticprocessnegativeregulationofhemostasisneuromuscularprocessossificationplateletaggregationpositiveregulationofchondrocyteproliferationproteinhomooligomerizationproteinprocessingproteinsecretionregulationofbonemineralizationregulationofgeneexpressionresponsetounfoldedproteinskeletalsystemdevelopmentskindevelopmenttendondevelopmentvascularassociatedsmoothmusclecelldevelopmentvascularassociatedsmoothmusclecontraction
Chymotrypsin-C
141
Chymotrypsin-C
17
2.1
nan
nan
CTRCCTRCQ99895Q99895cellularcalciumionhomeostasiscobalaminmetabolicprocessproteolysis
Lactotransferrin
424
Lactotransferrin
703
2.1
45
1.07
TRFLTRFLP24627P24627antibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidebonemorphogenesisdefenseresponsetoGram-negativebacteriuminnateimmuneresponseinmucosaironionhomeostasisironiontransportkillingofcellsofanotherorganismmembranedisruptioninanotherorganismnegativeregulationbyhostofviralprocessnegativeregulationofapoptoticprocessnegativeregulationofATP-dependentactivitynegativeregulationofcysteine-typeendopeptidaseactivitynegativeregulationoflipopolysaccharide-mediatedsignalingpathwaynegativeregulationofosteoclastdevelopmentnegativeregulationofsingle-speciesbiofilmformationinoronhostorganismnegativeregulationoftumornecrosisfactor(ligand)superfamilymember11productionnegativeregulationofviralgenomereplicationossificationpositiveregulationofbonemineralizationinvolvedinbonematurationpositiveregulationofchondrocyteproliferationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofosteoblastdifferentiationpositiveregulationofosteoblastproliferationpositiveregulationoftoll-likereceptor4signalingpathwayproteolysisregulationofcytokineproductionregulationoftumornecrosisfactorproduction
Formylglycine-generating enzyme
341
Arylsulfatase A
69
2.1
70
0.69
SUMF1ARSAQ8NBK3P15289glycosphingolipidmetabolicprocesspost-translationalproteinmodificationproteinoxidationlipidmetabolicprocess
Peroxiredoxin-4
127
Peroxiredoxin-4
248
2.0
nan
nan
1
✔PRDX4PRDX4O08807O08807cellredoxhomeostasisextracellularmatrixorganizationmalegonaddevelopmentnegativeregulationofmalegermcellproliferationpeptidyl-prolinehydroxylationto4-hydroxy-L-prolineproteinmaturationbyproteinfoldingreactiveoxygenspeciesmetabolicprocessresponsetooxidativestressspermatogenesis
Chymotrypsinogen B
1
Chymotrypsinogen A
122
2.0
nan
nan
CTRBCTRAP00767P00766digestionproteolysis
Breast cancer metastasis-suppressor 1
60
Breast cancer metastasis-suppressor 1
60
2.1
56
0.85
BRMS1BRMS1Q9HCU9Q9HCU9apoptoticprocesshistonedeacetylationnegativeregulationofcellmigrationnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofstemcellpopulationmaintenancenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofanoikispositiveregulationofproteindeacetylationpositiveregulationofstemcellpopulationmaintenanceregulationofapoptoticprocess
FAD-linked sulfhydryl oxidase ALR
197
FAD-linked sulfhydryl oxidase ALR
88
2.0
nan
nan
ALRALRQ63042Q63042cellularresponsetoactinomycinDcellularresponsetolipopolysaccharidecellularresponsetotoxicsubstancecellularresponsetotumornecrosisfactorliverdevelopmentliverregenerationnegativeregulationofapoptoticprocessnegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofoxidativestress-inducedneurondeathpositiveregulationofDNAbiosyntheticprocessresponsetolipopolysaccharide
Thioredoxin domain-containing protein 5
217
Peroxiredoxin-4
248
2.1
45
1.05
TXND5PRDX4Q8NBS9O08807negativeregulationofapoptoticprocessproteinfoldingcellredoxhomeostasisextracellularmatrixorganizationmalegonaddevelopmentnegativeregulationofmalegermcellproliferationpeptidyl-prolinehydroxylationto4-hydroxy-L-prolineproteinmaturationbyproteinfoldingreactiveoxygenspeciesmetabolicprocessresponsetooxidativestressspermatogenesis
Immunoglobulin gamma-1 heavy chain
222
Uncharacterized protein
239
2.1
nan
nan
IGG1Q8TCD0P0DOX5Q8TCD0adaptiveimmuneresponse
Immunoglobulin kappa constant
107
IgG H chain
239
2.0
nan
nan
IGKCS6B291P01834S6B291adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationretinahomeostasis
17-beta-hydroxysteroid dehydrogenase 14
255
17-beta-hydroxysteroid dehydrogenase 14
255
2.0
63
0.77
DHB14DHB14Q9BPX1Q9BPX1steroidcatabolicprocess
Amyloid-beta precursor protein
300
Amyloid-beta precursor protein
324
2.1
35
1.39
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Immunoglobulin kappa constant
107
IGH@ protein
238
2.0
nan
nan
IGKCQ6GMX6P01834Q6GMX6adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationretinahomeostasis
Protein capicua homolog
270
Protein capicua homolog
270
2.0
33
1.49
CICCICQ96RK0Q96RK0braindevelopmentlearningmemorynegativeregulationoftranscriptionDNA-templatedregulationoftranscriptionbyRNApolymeraseIIsocialbehavior
7SK snRNA methylphosphate capping enzyme
419
7SK snRNA methylphosphate capping enzyme
419
2.0
82
0.6
MEPCEMEPCEQ7L2J0Q7L2J0negativeregulationofchromatinbindingnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofproteinlocalizationtoCajalbodypositiveregulationofsnRNAtranscriptionbyRNApolymeraseIIRNAmethylationsnRNAmetabolicprocesssnRNAmodification
Thioredoxin-dependent peroxide reductase, mitochondrial
109
Thioredoxin-dependent peroxide reductase, mitochondrial
230
1.9
nan
nan
1
✔PRDX3PRDX3P35705P35705cellredoxhomeostasiscellularresponsetooxidativestresscellularresponsetoreactiveoxygenspecieshydrogenperoxidecatabolicprocessmaternalplacentadevelopmentmitochondrionorganizationmyeloidcelldifferentiationnegativeregulationofkinaseactivitypeptidyl-cysteineoxidationpositiveregulationofcellpopulationproliferationpositiveregulationofNF-kappaBtranscriptionfactoractivityregulationofmitochondrialmembranepotentialresponsetohydrogenperoxideresponsetolipopolysaccharide
Immunoglobulin heavy constant gamma 1
112
Immunoglobulin heavy constant gamma 1
112
2.0
32
1.53
IGHG1IGHG1P01857P01857adaptiveimmuneresponseantibody-dependentcellularcytotoxicityBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Natural killer cells antigen CD94
59
NKG2-A/NKG2-B type II integral membrane protein
116
2.0
61
0.81
KLRD1NKG2AQ13241P26715adaptiveimmuneresponsecellsurfacereceptorsignalingpathwaynaturalkillercellmediatedimmunitynegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofTcellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicityregulationofnaturalkillercellactivationstimulatoryC-typelectinreceptorsignalingpathwayCD8-positivegamma-deltaintraepithelialTcelldifferentiationinnateimmuneresponsenaturalkillercellinhibitorysignalingpathway
Immunoglobulin heavy constant gamma 1
103
Uncharacterized protein
239
2.0
nan
nan
IGHG1Q8TCD0P01857Q8TCD0adaptiveimmuneresponseantibody-dependentcellularcytotoxicityBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Urokinase-type plasminogen activator
168
Urokinase-type plasminogen activator
299
2.0
nan
nan
UROKUROKP00749P00749bloodcoagulationchemotaxisfibrinolysisnegativeregulationoffibrinolysisnegativeregulationofplasminogenactivationplasminogenactivationpositiveregulationofcellmigrationproteolysisregulationofcelladhesionregulationofcelladhesionmediatedbyintegrinregulationofcellpopulationproliferationregulationoffibrinolysisregulationofplasminogenactivationregulationofsignalingreceptoractivityregulationofsmoothmusclecellmigrationregulationofsmoothmusclecell-matrixadhesionregulationofwoundhealingresponsetohypoxiasignaltransductionsmoothmusclecellmigrationurokinaseplasminogenactivatorsignalingpathway
Immunoglobulin gamma-1 heavy chain
228
Immunoglobulin gamma-1 heavy chain
228
2.0
nan
nan
IGG1IGG1P0DOX5P0DOX5adaptiveimmuneresponse
Protein arginine N-methyltransferase 6
232
Protein arginine N-methyltransferase 6
53
2.1
nan
nan
ANM6ANM6Q6NZB1Q6NZB1cellularsenescencechromatinorganizationDNArepairhistoneH3-R2methylationhistonemethylationnegativeregulationofhistonedeacetylationnegativeregulationofhistoneH3-K4methylationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedpeptidyl-argininemethylationtoasymmetrical-dimethylargininepeptidyl-arginineN-methylationregulationofmitochondrionorganizationregulationofsignaltransductionbyp53classmediator
Coagulation factor XI
500
Coagulation factor XI
380
2.0
nan
nan
FA11FA11P03951P03951bloodcoagulationbloodcoagulationintrinsicpathwayplasminogenactivationpositiveregulationoffibrinolysisproteolysiszymogenactivation
Hepatocyte growth factor activator
521
Hepatocyte growth factor activator
394
2.0
62
0.8
HGFAHGFAQ04756Q04756bloodcoagulationproteolysiszymogenactivation
F-BAR domain only protein 2
147
F-BAR domain only protein 2
273
2.0
nan
nan
FCHO2FCHO2Q96CF5Q96CF5clathrincoatassemblyclathrin-dependentendocytosismembraneinvaginationproteinlocalizationtoplasmamembranesynapticvesicleendocytosis
IGH@ protein
238
Uncharacterized protein
239
2.0
nan
nan
Q6GMX6Q8TCD0Q6GMX6Q8TCD0
Immunoglobulin heavy constant alpha 1
123
Immunoglobulin heavy constant alpha 1
180
2.0
nan
nan
IGHA1IGHA1P01876P01876adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
Uncharacterized protein
245
Uncharacterized protein
239
2.0
nan
nan
Q6N089Q8TCD0Q6N089Q8TCD0
Translationally-controlled tumor protein
28
Translationally-controlled tumor protein
28
2.0
81
0.61
TCTPTCTPP13693P13693calciumiontransportcellularcalciumionhomeostasisnegativeregulationofapoptoticprocessnegativeregulationofectodermdevelopmentnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageregulationofapoptoticprocessresponsetovirusstemcellpopulationmaintenance
Potassium voltage-gated channel subfamily B member 1
133
Potassium voltage-gated channel subfamily B member 1
111
2.8
nan
nan
KCNB1KCNB1Q14721Q14721actionpotentialcellularresponsetocalciumioncellularresponsetoglucosestimuluscellularresponsetonutrientlevelsclusteringofvoltage-gatedpotassiumchannelsglucosehomeostasisglutamatereceptorsignalingpathwaynegativeregulationofinsulinsecretionpositiveregulationofcalciumion-dependentexocytosispositiveregulationofcatecholaminesecretionpositiveregulationoflong-termsynapticdepressionpositiveregulationofnorepinephrinesecretionpositiveregulationofproteintargetingtomembranepotassiumionexportacrossplasmamembranepotassiumiontransmembranetransportproteinhomooligomerizationproteinlocalizationtoplasmamembraneregulationofactionpotentialregulationofiontransmembranetransportregulationofmotorneuronapoptoticprocessresponsetoaxoninjuryresponsetoL-glutamatevesicledockinginvolvedinexocytosis
Enteropeptidase
788
Enteropeptidase
912
2.6
nan
nan
ENTKENTKP98072P98072proteindigestiontrypsinogenactivation
Oxidized low-density lipoprotein receptor 1
140
Oxidized low-density lipoprotein receptor 1
140
2.0
nan
nan
OLR1OLR1P78380P78380bloodcirculationcelldeathimmunesystemprocessinflammatoryresponseleukocytecell-celladhesionlipoproteinmetabolicprocessproteolysis
IGH@ protein
238
IGL@ protein
235
2.0
nan
nan
Q6GMX6Q6IPQ0Q6GMX6Q6IPQ0
G-rich sequence factor 1
476
G-rich sequence factor 1
476
2.0
nan
nan
GRSF1GRSF1Q12849Q12849anterior/posteriorpatternspecificationmorphogenesisofembryonicepitheliummRNApolyadenylationpositiveregulationofmitochondrialRNAcatabolicprocessregulationofRNAsplicingtRNAprocessing
Sodium/calcium exchanger 1
517
Sodium/calcium exchanger 1
517
2.7
81
0.46
NAC1NAC1P23685P23685calciumionimportcalciumionimportacrossplasmamembranecalciumiontransmembranetransportcellcommunicationcellularsodiumionhomeostasismetaliontransportpositiveregulationofbonemineralizationpositiveregulationoftheforceofheartcontractionresponsetomusclestretchsodiumionimportacrossplasmamembranesodiumiontransmembranetransport
Chymotrypsinogen B
19
Chymotrypsinogen B
140
2.0
66
0.74
CTRB1CTRB1P07338P07338digestionpositiveregulationofapoptoticprocessproteincatabolicprocessproteolysisresponsetocytokineresponsetofoodresponsetonutrientresponsetopeptidehormoneresponsetotoxicsubstance
Tumor necrosis factor ligand superfamily member 9
246
Tumor necrosis factor ligand superfamily member 9
246
2.0
nan
nan
TNFL9TNFL9P41274P41274immuneresponsemyeloiddendriticcelldifferentiationpositiveregulationofactivatedTcellproliferationpositiveregulationofcytotoxicTcelldifferentiationpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-6productionregulationofimmatureTcellproliferationinthymus
Immunoglobulin kappa constant
107
Immunoglobulin heavy constant gamma 1
103
2.0
nan
nan
IGKCIGHG1P01834P01857adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationretinahomeostasisantibody-dependentcellularcytotoxicitycomplement-dependentcytotoxicity
Repulsive guidance molecule B
139
Repulsive guidance molecule B
226
2.0
45
1.09
RGMBRGMBQ6NW40Q6NW40BMPsignalingpathwaycelladhesionpositiveregulationoftranscriptionDNA-templatedsignaltransduction
Interleukin-12 subunit beta
199
Interleukin-12 subunit alpha
96
2.1
nan
nan
IL12BIL12AP29460P29459cellmigrationcellularresponsetointerferon-gammacellularresponsetolipopolysaccharidecytokine-mediatedsignalingpathwaydefenseresponsetoGram-negativebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponsenaturalkillercellactivationnaturalkillercellactivationinvolvedinimmuneresponsenegativeregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisnegativeregulationofinflammatoryresponsetoantigenicstimulusnegativeregulationofinterleukin-10productionnegativeregulationofinterleukin-17productionnegativeregulationofproteinsecretionnegativeregulationofsmoothmusclecellproliferationnegativeregulationofvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofactivatedTcellproliferationpositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcelladhesionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-17productionpositiveregulationoflymphocyteproliferationpositiveregulationofmemoryTcelldifferentiationpositiveregulationofmononuclearcellproliferationpositiveregulationofnaturalkillercellactivationpositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationofnaturalkillercellproliferationpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofNKTcellactivationpositiveregulationofNKTcellproliferationpositiveregulationofosteoclastdifferentiationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellapoptoticprocesspositiveregulationofTcellmediatedcytotoxicitypositiveregulationofTcellproliferationpositiveregulationofT-helper1typeimmuneresponsepositiveregulationofT-helper17celllineagecommitmentpositiveregulationofT-helper17typeimmuneresponsepositiveregulationoftissueremodelingpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofcytokineproductionregulationoftyrosinephosphorylationofSTATproteinresponsetoUV-BsensoryperceptionofpainsexualreproductionTcellproliferationT-helper1typeimmuneresponseT-helpercelldifferentiationcellularresponsetovirusdefenseresponsetoGram-positivebacteriumextrinsicapoptoticsignalingpathwaypositiveregulationofdendriticcellchemotaxispositiveregulationofnaturalkillercellmediatedcytotoxicityresponsetolipopolysaccharideresponsetovirus
Immunoglobulin lambda constant 3
105
Uncharacterized protein
245
2.0
nan
nan
IGLC3A8K008P0DOY3A8K008adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Transforming growth factor beta-1 proprotein
33
Transforming growth factor beta activator LRRC32
350
2.0
62
0.79
TGFB1LRC32P01137Q14392aorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaycellmigrationcell-celljunctionorganizationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluschondrocytedifferentiationcommon-partnerSMADproteinphosphorylationconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingembryonicliverdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayheartdevelopmentheartvalvemorphogenesishematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphnodedevelopmentmacrophagederivedfoamcelldifferentiationMAPKcascademembraneproteinintracellulardomainproteolysisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofcytolysisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixdisassemblynegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofmacrophagecytokineproductionnegativeregulationofmiRNAmaturationnegativeregulationofmiRNAtranscriptionnegativeregulationofmiRNA-mediatedgenesilencingnegativeregulationofmyoblastdifferentiationnegativeregulationofproteinlocalizationtoplasmamembranenegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationoftranscriptionDNA-templatedneuraltubeclosureneuraltubedevelopmentossificationinvolvedinboneremodelingpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixassemblypositiveregulationoffibroblastmigrationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationofSMADproteinsignaltransductionpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularpermeabilityproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofbindingregulationofbloodvesselremodelingregulationofcellmigrationregulationofcellpopulationproliferationregulationofDNAbindingregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesisnegativeregulationofactivatedTcellproliferationnegativeregulationofcytokineproductionregulationoftransforminggrowthfactorbetaactivationregulationoftransforminggrowthfactorbeta3activationsecondarypalatedevelopment
Nesprin-4
382
Nesprin-4
382
2.8
42
0.85
SYNE4SYNE4Q8N205Q8N205establishmentofepithelialcellapical/basalpolarity
Beta-hexosaminidase subunit beta
309
Beta-hexosaminidase subunit beta
360
2.1
49
0.99
HEXBHEXBP07686P07686astrocytecellmigrationcellularcalciumionhomeostasisgangliosidecatabolicprocessglycosaminoglycanmetabolicprocesslipidstoragelocomotorybehaviorlysosomeorganizationmaintenanceoflocationincellmalecourtshipbehaviormyelinationneuromuscularprocesscontrollingbalanceneuroncellularhomeostasisoligosaccharidecatabolicprocessoogenesispenetrationofzonapellucidaphospholipidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIproteinmetabolicprocessregulationofcellshapesensoryperceptionofsoundsinglefertilizationskeletalsystemdevelopment
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
518
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
545
2.7
68
0.55
MAGI1MAGI1Q6RHR9Q6RHR9positiveregulationofcell-celladhesionsignaltransduction
T-box transcription factor TBX5
202
T-box transcription factor TBX5
202
2.1
71
0.67
TBX5TBX5Q99593Q99593atrialseptummorphogenesisatrioventricularbundlecelldifferentiationatrioventricularnodecelldevelopmentatrioventricularnodecellfatecommitmentatrioventricularvalvemorphogenesisbundleofHiscelltoPurkinjemyocytecommunicationbyelectricalcouplingbundleofHisdevelopmentcardiacleftventricleformationcardiacmusclecellproliferationcellfatespecificationcellmigrationinvolvedincoronaryvasculogenesiscell-cellsignalingcell-cellsignalinginvolvedincardiacconductionembryonicforelimbmorphogenesisembryoniclimbmorphogenesisendocardialcushiondevelopmentforelimbmorphogenesisheartdevelopmentlungdevelopmentmorphogenesisofanepitheliumnegativeregulationofcardiacmusclecellproliferationnegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationofepithelialtomesenchymaltransitionpatternspecificationprocesspericardiumdevelopmentpositiveregulationofcardiacconductionpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcardioblastdifferentiationpositiveregulationofcellcommunicationbyelectricalcouplinginvolvedincardiacconductionpositiveregulationofgapjunctionassemblypositiveregulationofsecondaryheartfieldcardioblastproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofatrialcardiacmusclecellmembranedepolarizationregulationoftranscriptionbyRNApolymeraseIIsinoatrialnodedevelopmenttranscriptionbyRNApolymeraseIIventricularseptumdevelopment
Pancreatic trypsin inhibitor
49
Pancreatic trypsin inhibitor
73
2.0
79
0.62
BPT1BPT1P00974P00974negativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
FAD-linked sulfhydryl oxidase ALR
204
FAD-linked sulfhydryl oxidase ALR
95
2.0
41
1.21
ALRALRP55789P55789cellularresponsetoactinomycinDcellularresponsetolipopolysaccharidecellularresponsetotoxicsubstancecellularresponsetotumornecrosisfactorliverdevelopmentliverregenerationnegativeregulationofapoptoticprocessnegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofoxidativestress-inducedneurondeathpositiveregulationofDNAbiosyntheticprocess
Toll-like receptor 2
640
Toll-like receptor 2
750
2.0
55
0.89
TLR2TLR2O60603O60603apoptoticprocesscellactivationcellularresponsetobacteriallipopeptidecellularresponsetodiacylbacteriallipopeptidecellularresponsetointerferon-gammacellularresponsetolipoteichoicacidcellularresponsetotriacylbacteriallipopeptidecentralnervoussystemmyelinformationdefenseresponsetoGram-positivebacteriumdefenseresponsetovirusdetectionofdiacylbacteriallipopeptidedetectionoftriacylbacteriallipopeptideI-kappaBphosphorylationimmuneresponseinflammatoryresponseinnateimmuneresponselearningleukotrienemetabolicprocessmicrogliadevelopmentmicroglialcellactivationMyD88-dependenttoll-likereceptorsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofphagocytosisnegativeregulationofsynapseassemblynitricoxidemetabolicprocesspositiveregulationofcellularresponsetomacrophagecolony-stimulatingfactorstimuluspositiveregulationofchemokineproductionpositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-18productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofmatrixmetallopeptidasesecretionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofoligodendrocytedifferentiationpositiveregulationoftoll-likereceptorsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationofWntsignalingpathwayresponsetofattyacidresponsetohypoxiaresponsetoinsulinresponsetoprogesteroneresponsetotoxicsubstancesignaltransductiontoll-likereceptor2signalingpathwaytoll-likereceptorsignalingpathwaytoll-likereceptorTLR6
E3 ubiquitin-protein ligase SMURF2
716
Polyubiquitin-B
229
2.0
nan
nan
SMUF2UBBQ9HAU4P0CG47negativeregulationofBMPsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofcanonicalWntsignalingpathwaypositiveregulationoftrophoblastcellmigrationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationproteinubiquitinationregulationoftransforminggrowthfactorbetareceptorsignalingpathwayubiquitin-dependentproteincatabolicprocessubiquitin-dependentSMADproteincatabolicprocessWntsignalingpathwayplanarcellpolaritypathwayenergyhomeostasisfatpaddevelopmentfemalegonaddevelopmentfemalemeiosisIhypothalamusgonadotrophin-releasinghormoneneurondevelopmentmalemeiosisImitochondriontransportalongmicrotubulemodification-dependentproteincatabolicprocessneuronprojectionmorphogenesispositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofproteinmonoubiquitinationpositiveregulationofproteinubiquitinationregulationofmitochondrialmembranepotentialregulationofneurondeathregulationofproteasomalproteincatabolicprocessseminiferoustubuledevelopment
Lysosomal protective protein
281
Lysosomal protective protein
331
2.0
47
1.05
PPGBPPGBP10619P10619intracellularproteintransportnegativeregulationofchaperone-mediatedautophagyproteolysisregulationofchaperone-mediatedautophagyregulationofproteinstability
C4b-binding protein alpha chain
546
C4b-binding protein alpha chain
558
2.0
53
0.92
C4BPAC4BPAP04003P04003complementactivationclassicalpathwayinnateimmuneresponsenegativeregulationofcomplementactivationclassicalpathwaypositiveregulationofproteincatabolicprocessregulationofopsonizationresponsetosymbioticbacterium
Pro-cathepsin H
327
Pro-cathepsin H
102
2.0
96
0.51
CATHCATHO46427O46427bradykinincatabolicprocesscellularresponsetothyroidhormonestimulusdichotomoussubdivisionofterminalunitsinvolvedinlungbranchingERK1andERK2cascadeimmuneresponse-regulatingsignalingpathwaymembraneproteinproteolysismetanephrosdevelopmentnegativeregulationofapoptoticprocessneuropeptidecatabolicprocesspositiveregulationofangiogenesispositiveregulationofapoptoticsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofgeneexpressionpositiveregulationofpeptidaseactivityproteindestabilizationproteolysisproteolysisinvolvedinproteincatabolicprocessresponsetoretinoicacidsurfactanthomeostasisTcellmediatedcytotoxicityzymogenactivation
TNF receptor-associated factor 3
533
Mitochondrial antiviral-signaling protein
140
2.0
72
0.68
TRAF3MAVSQ60803Q8VCF0apoptoticprocessinnateimmuneresponsenegativeregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofJNKcascadeproteinK63-linkedubiquitinationregulationofapoptoticprocessregulationofcytokineproductionregulationofdefenseresponsetovirusregulationofI-kappaBkinase/NF-kappaBsignalingregulationofinterferon-betaproductionregulationofproteolysisTollsignalingpathwaytoll-likereceptorsignalingpathwaytumornecrosisfactor-mediatedsignalingpathwayactivationofinnateimmuneresponsecellularresponsetoexogenousdsRNAdefenseresponsetobacteriumdefenseresponsetovirusnegativeregulationofviralgenomereplicationpositiveregulationofchemokine(C-Cmotif)ligand5productionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofIP-10productionpositiveregulationofmyeloiddendriticcellcytokineproductionpositiveregulationofproteinimportintonucleuspositiveregulationofproteinphosphorylationpositiveregulationofresponsetocytokinestimuluspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIinterferonproductionpositiveregulationoftypeIinterferon-mediatedsignalingpathwayregulationofperoxisomeorganizationRIG-Isignalingpathwaysignaltransduction
Uteroglobin
90
Uteroglobin
24
2.0
46
1.08
UTERUTERP02779P02779signaltransduction
DNA topoisomerase 2-binding protein 1
1299
Histone lysine demethylase PHF8
844
2.0
54
0.91
TOPB1PHF8Q92547Q9UPP1cellularresponsetoDNAdamagestimulusDNAmetabolicprocessDNArepairDNAreplicationinitiationhomologousrecombinationmitoticDNAreplicationcheckpointsignalingmitoticG2DNAdamagecheckpointsignalingresponsetoionizingradiationbraindevelopmentchromatinorganizationG1/StransitionofmitoticcellcyclehistoneH3-K27demethylationhistoneH3-K36demethylationhistoneH3-K9demethylationhistoneH4-K20demethylationnegativeregulationofribosomalDNAheterochromatinassemblypositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranscriptionDNA-templatedproteindemethylationregulationoftranscriptionbyRNApolymeraseII
Ubiquitin-associated protein 1
452
Ubiquitin-associated protein 1
452
2.0
30
1.64
UBAP1UBAP1Q9NZ09Q9NZ09membranefissionmultivesicularbodyassemblyproteintransporttovacuoleinvolvedinubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathwayubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathway
Sorting nexin-17
320
Krev interaction trapped protein 1
228
2.0
58
0.85
SNX17KRIT1Q15036O00522aortadevelopmentcardiacseptumdevelopmentcholesterolcatabolicprocesscoronaryvasculaturedevelopmentendocyticrecyclingendosomaltransportintracellularproteintransportkidneydevelopmentreceptor-mediatedendocytosisregulationofendocytosissignaltransductionangiogenesiscellredoxhomeostasisendotheliumdevelopmentintegrinactivationnegativeregulationofangiogenesisnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofendothelialcellmigrationnegativeregulationofendothelialcellproliferationpositiveregulationofproteinbindingregulationofangiogenesisregulationofestablishmentofcellpolaritysmallGTPasemediatedsignaltransduction
Protein scribble homolog
864
Protein scribble homolog
864
2.0
81
0.61
SCRIBSCRIBQ14160Q14160activationofGTPaseactivityapoptoticprocessinvolvedinmorphogenesisastrocytecellmigrationauditoryreceptorcellstereociliumorganizationcellmigrationcellpopulationproliferationcell-celladhesioncochlearnucleusdevelopmentestablishmentofapical/basalcellpolarityestablishmentofTcellpolarityestablishmentormaintenanceofepithelialcellapical/basalpolaritymammaryglandductmorphogenesisnegativeregulationofactivatedTcellproliferationnegativeregulationofmitoticcellcycleneuraltubeclosureneurotransmitterreceptortransportpostsynapticmembranetoendosomeneurotransmitterreceptortransportendosometopostsynapticmembranepolarizedepithelialcelldifferentiationpositivechemotaxispositiveregulationofapoptoticprocesspositiveregulationofinterferon-gammaproductionpositiveregulationofreceptorrecyclingpost-analtailmorphogenesisproteinlocalizationtoadherensjunctionreceptorclusteringreceptorlocalizationtosynapseregulationofpostsynapticneurotransmitterreceptorinternalizationsynapticvesicleendocytosissynapticvesicletargetingwoundhealing
Interleukin-17A
129
Interleukin-17F
47
2.0
36
1.36
IL17IL17FQ16552Q96PD4adaptiveimmuneresponseapoptoticprocesscelldeathcell-cellsignalingcellularresponsetointerleukin-1defenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumfibroblastactivationgranulocytemigrationimmuneresponseinflammatoryresponseinnateimmuneresponseinterleukin-17-mediatedsignalingpathwayintestinalepithelialstructuremaintenanceNotchsignalingpathwaypositiveregulationofantimicrobialpeptideproductionpositiveregulationofbicellulartightjunctionassemblypositiveregulationofchemokine(C-X-Cmotif)ligand1productionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-16productionpositiveregulationofinterleukin-23productionpositiveregulationofinterleukin-6productionpositiveregulationofosteoclastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductioncartilagedevelopmentnegativeregulationofangiogenesispositiveregulationofcytokineproductionpositiveregulationoflymphotoxinAproductionregulationofgranulocytemacrophagecolony-stimulatingfactorproductionregulationofinterleukin-2productionregulationofinterleukin-6productionregulationofinterleukin-8productionregulationoftransforminggrowthfactorbetareceptorsignalingpathway
Tissue-type plasminogen activator
299
Tissue-type plasminogen activator
430
2.0
62
0.79
TPATPAP00750P00750bloodcoagulationcellularresponsetodexamethasonestimuluscellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetoluteinizinghormonestimulusfibrinolysisnegativeregulationoffibrinolysisnegativeregulationofplasminogenactivationnegativeregulationofproteolysisplasminogenactivationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofovulationpreventionofpolyspermyproteinmodificationprocessproteolysisregulationofsynapticplasticityresponsetocAMPresponsetofattyacidresponsetohypoxiasmoothmusclecellmigrationsynaptictransmissionglutamatergictrans-synapticsignalingbyBDNFmodulatingsynaptictransmission
Ubiquitin-conjugating enzyme E2 S
95
Polyubiquitin-B
229
2.0
nan
nan
UBE2SUBBQ16763P0CG47anaphase-promotingcomplex-dependentcatabolicprocesscelldivisionexitfrommitosisfreeubiquitinchainpolymerizationpositiveregulationofubiquitinproteinligaseactivityproteinK11-linkedubiquitinationproteinK27-linkedubiquitinationproteinK29-linkedubiquitinationproteinK6-linkedubiquitinationproteinK63-linkedubiquitinationproteinmodificationprocessproteinpolyubiquitinationubiquitin-dependentproteincatabolicprocessenergyhomeostasisfatpaddevelopmentfemalegonaddevelopmentfemalemeiosisIhypothalamusgonadotrophin-releasinghormoneneurondevelopmentmalemeiosisImitochondriontransportalongmicrotubulemodification-dependentproteincatabolicprocessneuronprojectionmorphogenesispositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofproteinmonoubiquitinationpositiveregulationofproteinubiquitinationproteinubiquitinationregulationofmitochondrialmembranepotentialregulationofneurondeathregulationofproteasomalproteincatabolicprocessseminiferoustubuledevelopment
Hepatocyte growth factor receptor
584
Hepatocyte growth factor receptor
26
2.0
60
0.82
METMETP08581P08581branchingmorphogenesisofanepithelialtubecellmigrationcellsurfacereceptorsignalingpathwayendothelialcellmorphogenesisestablishmentofskinbarrierliverdevelopmentnegativeregulationofautophagynegativeregulationofguanyl-nucleotideexchangefactoractivitynegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofRhoproteinsignaltransductionnegativeregulationofstressfiberassemblynegativeregulationofthrombin-activatedreceptorsignalingpathwaynervoussystemdevelopmentneurondifferentiationpancreasdevelopmentphagocytosispositivechemotaxispositiveregulationofendothelialcellchemotaxispositiveregulationofkinaseactivitypositiveregulationofmicrotubulepolymerizationpositiveregulationofproteinkinaseBsignalingpositiveregulationoftranscriptionbyRNApolymeraseIIsemaphorin-plexinsignalingpathwaysignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
MAP/microtubule affinity-regulating kinase 3
213
MAP/microtubule affinity-regulating kinase 3
213
2.0
70
0.7
MARK3MARK3P27448P27448intracellularsignaltransductionmicrotubulecytoskeletonorganizationnegativeregulationofhipposignalingpeptidyl-serineautophosphorylationpeptidyl-serinephosphorylationpositiveregulationofproteinbindingproteinphosphorylation
E3 ubiquitin-protein ligase NEDD4
1286
Polyubiquitin-B
305
2.0
nan
nan
NEDD4UBBP46934P0CG53cellularresponsetoUVformationofstructureinvolvedinasymbioticprocessglucocorticoidreceptorsignalingpathwaylysosomaltransportnegativeregulationofsodiumiontransmembranetransporteractivitynegativeregulationofsodiumiontransportnegativeregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoUV-inducedDNAdamagenegativeregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayneuromuscularjunctiondevelopmentneuronprojectiondevelopmentpositiveregulationofnucleocytoplasmictransportpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteincatabolicprocessprogesteronereceptorsignalingpathwayproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinK63-linkedubiquitinationproteinpolyubiquitinationproteintargetingtolysosomeproteinubiquitinationreceptorcatabolicprocessreceptorinternalizationregulationofdendritemorphogenesisregulationofiontransmembranetransportregulationofmacroautophagyregulationofmembranepotentialregulationofpotassiumiontransmembranetransporteractivityregulationofsynapseorganizationresponsetocalciumionubiquitin-dependentproteincatabolicprocessubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathwayviralbuddingenergyhomeostasisfatpaddevelopmentfemalegonaddevelopmentfemalemeiosisIhypothalamusgonadotrophin-releasinghormoneneurondevelopmentmalemeiosisImitochondriontransportalongmicrotubulemodification-dependentproteincatabolicprocessneuronprojectionmorphogenesispositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofproteinmonoubiquitinationregulationofmitochondrialmembranepotentialregulationofneurondeathregulationofproteasomalproteincatabolicprocessseminiferoustubuledevelopment
Hepatocyte growth factor
487
Hepatocyte growth factor
604
2.0
60
0.82
HGFHGFP14210P14210animalorganregenerationcellchemotaxiscellmorphogenesiscellularresponsetohepatocytegrowthfactorstimulusepithelialcellproliferationepithelialtomesenchymaltransitionhepatocytegrowthfactorreceptorsignalingpathwayliverdevelopmentmitoticcellcyclemyoblastproliferationnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-6productionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofreleaseofcytochromecfrommitochondriapositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofinterleukin-10productionpositiveregulationofMAPKcascadepositiveregulationofmyelinationpositiveregulationofneuronprojectionregenerationpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofbranchinginvolvedinsalivaryglandmorphogenesisbymesenchymal-epithelialsignalingregulationofp38MAPKcascaderegulationoftau-proteinkinaseactivityskeletalmusclecellproliferation
Kinesin-like protein KIF20A
606
Kinesin-like protein KIF20A
606
2.0
47
1.04
KI20AKI20AP97329P97329microtubulebundleformationmicrotubule-basedmovementmidbodyabscissionmitoticcytokinesisproteintransportregulationofcytokinesis
Bcl-2-related protein A1
4
Bcl-2-related protein A1
4
2.1
55
0.88
B2LA1B2LA1Q16548Q16548extrinsicapoptoticsignalingpathwayinabsenceofligandintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofapoptoticprocess
Amyloid beta precursor like protein 2
319
Amyloid beta precursor like protein 2
343
2.1
76
0.63
APLP2APLP2Q06481Q06481axonogenesiscentralnervoussystemdevelopmentGprotein-coupledreceptorsignalingpathwayregulationofcellularproteinmetabolicprocess
Guanine nucleotide exchange factor VAV2
749
Thioredoxin-interacting protein
333
2.1
nan
nan
VAV2TXNIPP52735Q9H3M7angiogenesiscellmigrationcellularresponsetoxenobioticstimulusFc-epsilonreceptorsignalingpathwayFc-gammareceptorsignalingpathwayinvolvedinphagocytosislamellipodiumassemblyplateletactivationpositiveregulationofphosphatidylinositol3-kinaseactivityregulationofcellsizeregulationofGTPaseactivityregulationofsmallGTPasemediatedsignaltransductionsignaltransductionsmallGTPasemediatedsignaltransductionvascularendothelialgrowthfactorreceptorsignalingpathwaycellcyclecellularresponsetotumorcellkeratinocytedifferentiationnegativeregulationofcelldivisionnegativeregulationoftranscriptionbyRNApolymeraseIIplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofapoptoticprocessproteinimportintonucleusproteintransportregulationofcellpopulationproliferationresponsetocalciumionresponsetoestradiolresponsetoglucoseresponsetohydrogenperoxideresponsetomechanicalstimulusresponsetoprogesteroneresponsetoxenobioticstimulus
BRCA1-associated RING domain protein 1
743
BRCA1-associated RING domain protein 1
743
2.0
55
0.9
BARD1BARD1Q99728Q99728cellularresponsetoDNAdamagestimuluscellularresponsetoionizingradiationDNArepairDNAstrandresectioninvolvedinreplicationforkprocessinghistoneH2AK63-linkeddeubiquitinationhistoneH2AmonoubiquitinationhomologousrecombinationmitoticG2/Mtransitioncheckpointnegativeregulationofapoptoticprocessnegativeregulationofcellcycle"negativeregulationofmRNA3-endprocessing"negativeregulationofproteinexportfromnucleuspositiveregulationofapoptoticprocesspositiveregulationofproteincatabolicprocessproteinautoubiquitinationproteinK6-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationofcellcycleregulationofDNAdamagecheckpointregulationofDNArepairregulationofphosphorylationtissuehomeostasis
IgG H chain
245
IGL@ protein
235
2.0
nan
nan
S6C4S0Q6IPQ0S6C4S0Q6IPQ0
TNFAIP3-interacting protein 2
275
TNFAIP3-interacting protein 2
275
2.0
34
1.45
TNIP2TNIP2Q8NFZ5Q8NFZ5apoptoticprocessCD40signalingpathwaycellularresponsetolipopolysaccharideinflammatoryresponseinterleukin-1-mediatedsignalingpathwaynegativeregulationofendothelialcellapoptoticprocesspositiveregulationofBcellactivationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofmacrophageactivationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinstabilizationregulationoftranscriptionbyRNApolymeraseIItoll-likereceptor2signalingpathwaytoll-likereceptor3signalingpathwaytoll-likereceptor9signalingpathway
E3 ubiquitin-protein ligase HUWE1
4341
Polyubiquitin-B
229
2.0
nan
nan
HUWE1UBBQ7Z6Z7P0CG47base-excisionrepaircelldifferentiationcircadianregulationofgeneexpressionGolgiorganizationhistoneubiquitinationmembranefusionnegativeregulationofmitochondrialfusionpositiveregulationofmitophagyinresponsetomitochondrialdepolarizationpositiveregulationofproteintargetingtomitochondrionpositiveregulationofproteinubiquitinationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinmonoubiquitinationproteinpolyubiquitinationproteinubiquitinationenergyhomeostasisfatpaddevelopmentfemalegonaddevelopmentfemalemeiosisIhypothalamusgonadotrophin-releasinghormoneneurondevelopmentmalemeiosisImitochondriontransportalongmicrotubulemodification-dependentproteincatabolicprocessneuronprojectionmorphogenesispositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofproteinmonoubiquitinationregulationofmitochondrialmembranepotentialregulationofneurondeathregulationofproteasomalproteincatabolicprocessseminiferoustubuledevelopment
Tumor suppressor candidate 3
99
Protein cereblon
234
2.0
49
1.0
TUSC3CRBNQ13454Q96SW2cognitionmagnesiumiontransportproteinN-linkedglycosylationproteinN-linkedglycosylationviaasparaginetransmembranetransportlocomotoryexplorationbehaviornegativeregulationoflargeconductancecalcium-activatedpotassiumchannelactivitynegativeregulationofprotein-containingcomplexassemblypositiveregulationofprotein-containingcomplexassemblyproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitination
Retinol-binding protein 2
28
Retinol-binding protein 2
28
2.0
59
0.83
RET2RET2P50120P50120epidermisdevelopmentfattyacidtransportvitaminAmetabolicprocess
Glutamate receptor 2
212
Glutamate receptor 2
212
2.0
54
0.91
GRIA2GRIA2P19491P19491chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumion
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
267
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
610
2.0
59
0.83
PDE4BPDE4BQ07343Q07343cAMPcatabolicprocesscellularresponsetoepinephrinestimuluscellularresponsetolipopolysaccharidecellularresponsetoxenobioticstimulusleukocytemigrationnegativeregulationofadenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocessnegativeregulationofrelaxationofcardiacmuscleneutrophilchemotaxisneutrophilhomeostasispositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-2productionregulationofcardiacmusclecellcontractionregulationofhighvoltage-gatedcalciumchannelactivitysignaltransductionTcellreceptorsignalingpathway
Egl nine homolog 1
21
Hypoxia-inducible factor 1-alpha
412
2.0
53
0.93
EGLN1HIF1AQ9GZT9Q16665cardiacmuscletissuemorphogenesiscellularironionhomeostasiscellularresponsetohypoxiahearttrabeculaformationlabyrinthinelayerdevelopmentnegativeregulationofcyclic-nucleotidephosphodiesteraseactivitynegativeregulationofDNA-bindingtranscriptionfactoractivityoxygenhomeostasispeptidyl-prolinehydroxylationto4-hydroxy-L-prolinepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofangiogenesisregulationofneurondeathregulationofpostsynapseorganizationregulationofproteincatabolicprocessatpostsynapsemodulatingsynaptictransmissionresponsetohypoxiaresponsetonitricoxideventricularseptummorphogenesisangiogenesisaxonaltransportofmitochondrionB-1Bcellhomeostasisbonemineralizationcardiacventriclemorphogenesiscellularglucosehomeostasiscellularresponsetointerleukin-1cellularresponsetoviruscerebralcortexdevelopmentchondrocytedifferentiationcollagenmetabolicprocessconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingdigestivetractmorphogenesisdopaminergicneurondifferentiationelastinmetabolicprocessembryonichemopoiesisembryonicplacentadevelopmentepithelialcelldifferentiationinvolvedinmammaryglandalveolusdevelopmentepithelialtomesenchymaltransitionglandularepithelialcellmaturationheartloopinghemoglobinbiosyntheticprocesshypoxia-induciblefactor-1alphasignalingpathwayinsulinsecretioninvolvedincellularresponsetoglucosestimulusintestinalepithelialcellmaturationirismorphogenesislactatemetabolicprocesslactationmesenchymalcellapoptoticprocessmusclecellcellularhomeostasisnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofgrowthnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofthymocyteapoptoticprocessnegativeregulationofTORsignalingneuralcrestcellmigrationneuralfoldelevationformationneuroblastproliferationneuronapoptoticprocessoutflowtractmorphogenesispositiveregulationofangiogenesispositiveregulationofautophagyofmitochondrionpositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofchemokineproductionpositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellmigrationpositiveregulationoferythrocytedifferentiationpositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhormonebiosyntheticprocesspositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofmacroautophagypositiveregulationofmiRNAtranscriptionpositiveregulationofneuroblastproliferationpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofsignalingreceptoractivitypositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofaerobicrespirationregulationofgeneexpressionregulationofglycolyticprocessregulationofproteinneddylationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetooxidativestressregulationoftranscriptionDNA-templatedregulationoftransforminggrowthfactorbeta2productionresponsetoironionresponsetomuscleactivityresponsetoreactiveoxygenspeciesretinavasculaturedevelopmentincamera-typeeyesignaltransductionTORsignalingvascularendothelialgrowthfactorproductionvisuallearning
Immunoglobulin heavy constant gamma 1
356
Immunoglobulin heavy constant gamma 1
349
2.0
63
0.78
IGHG1IGHG1P01857P01857adaptiveimmuneresponseantibody-dependentcellularcytotoxicityBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Glutamate receptor 2
217
Glutamate receptor 2
217
2.0
67
0.73
GRIA2GRIA2P19491P19491chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumion
Integrin alpha-X
920
Integrin beta-2
674
2.0
61
0.81
ITAXITB2P20702P05107animalorganmorphogenesiscelladhesioncelladhesionmediatedbyintegrincell-celladhesioncell-matrixadhesiondefenseresponsetovirusheterotypiccell-celladhesionintegrin-mediatedsignalingpathwaypositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialtubemorphogenesispositiveregulationofgeneexpressionpositiveregulationofmyelinationamyloid-betaclearanceapoptoticprocesscellmigrationcell-celladhesionviaplasma-membraneadhesionmoleculescell-cellsignalingcellularresponsetolow-densitylipoproteinparticlestimulusendodermalcelldifferentiationinflammatoryresponseleukocytecell-celladhesionmicroglialcellactivationnegativeregulationofdopaminemetabolicprocessneutrophilchemotaxisneutrophilmigrationphagocytosisengulfmentpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofneurondeathpositiveregulationofneutrophildegranulationpositiveregulationofprostaglandin-Esynthaseactivitypositiveregulationofproteintargetingtomembranepositiveregulationofsuperoxideaniongenerationreceptorclusteringreceptorinternalizationreceptor-mediatedendocytosisregulationofcellshaperegulationofpeptidyl-tyrosinephosphorylation
Frizzled-7
210
Frizzled-7
210
2.0
54
0.91
FZD7FZD7O75084O75084canonicalWntsignalingpathwaycellularresponsetoretinoicacidmesenchymaltoepithelialtransitionnegativeregulationofcardiacmusclecelldifferentiationnegativeregulationofcell-substrateadhesionnegativeregulationofectodermalcellfatespecificationneurondifferentiationnon-canonicalWntsignalingpathwayviaJNKcascadepositiveregulationofepithelialcellproliferationinvolvedinwoundhealingpositiveregulationofJNKcascadepositiveregulationofphosphorylationpositiveregulationoftranscriptionDNA-templatedregulationofcanonicalWntsignalingpathwayregulationoftranscriptionDNA-templatedskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationsomaticstemcelldivisionstemcellpopulationmaintenancesubstrateadhesion-dependentcellspreadingTcelldifferentiationinthymusWntsignalingpathwayplanarcellpolaritypathway
Glutamate receptor 2
213
Glutamate receptor 2
213
2.0
60
0.81
GRIA2GRIA2P19491P19491chemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumion
Amyloid-beta precursor protein
7
Amyloid-beta precursor protein
3
2.0
nan
nan
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Store-operated calcium entry-associated regulatory factor
320
Store-operated calcium entry-associated regulatory factor
98
2.0
54
0.91
SARAFSARAFQ96BY9Q96BY9calciumiontransportregulationofstore-operatedcalciumentry
Cathelicidin antimicrobial peptide
24
Cathelicidin antimicrobial peptide
24
2.1
45
1.06
CAMPCAMPP49913P49913antibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetointerleukin-1cellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetopeptidoglycancellularresponsetotumornecrosisfactorchronicinflammatoryresponsecytolysisbyhostofsymbiontcellsdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellsmodulationofprocessofanotherorganismneutrophilactivationpositiveregulationofangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofinterleukin-8productionpositiveregulationofproteinphosphorylationresponsetoyeast
Immunoglobulin heavy constant gamma 1
349
Immunoglobulin heavy constant gamma 1
349
2.0
76
0.65
IGHG1IGHG1P01857P01857adaptiveimmuneresponseantibody-dependentcellularcytotoxicityBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Glutamate receptor ionotropic, kainate 2
94
Glutamate receptor ionotropic, kainate 2
236
2.1
60
0.8
GRIK2GRIK2P42260P42260behavioralfearresponsecellularcalciumionhomeostasischemicalsynaptictransmissiondetectionofcoldstimulusinvolvedinthermoceptionexcitatorypostsynapticpotentialinhibitorypostsynapticpotentialmodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnegativeregulationofsynaptictransmissionglutamatergicneuronapoptoticprocessneuronalactionpotentialpositiveregulationofneuronapoptoticprocesspositiveregulationofsynaptictransmissionpresynapticmodulationofchemicalsynaptictransmissionreceptorclusteringregulationofJNKcascaderegulationoflong-termneuronalsynapticplasticityregulationofmembranepotentialregulationofshort-termneuronalsynapticplasticitysynaptictransmissionglutamatergic
Integrin alpha-IIb
959
Integrin beta-3
688
2.0
nan
nan
ITA2BITB3Q17R67P05106angiogenesiscelladhesionmediatedbyintegrincell-celladhesioncell-matrixadhesionintegrin-mediatedsignalingpathwayactivationofproteinkinaseactivityangiogenesisinvolvedinwoundhealingapolipoproteinA-I-mediatedsignalingpathwayapoptoticcellclearancebloodcoagulationcelladhesioncellmigrationcell-substrateadhesioncell-substratejunctionassemblycellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetomechanicalstimuluscellularresponsetoplatelet-derivedgrowthfactorstimuluscellularresponsetoxenobioticstimulusembryoimplantationheterotypiccell-celladhesionmesodermalcelldifferentiationnegativechemotaxisnegativeregulationofcelldeathnegativeregulationoflipidstoragenegativeregulationoflipidtransportnegativeregulationoflipoproteinmetabolicprocessnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofmacrophagederivedfoamcelldifferentiationplateletactivationplateletaggregationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofadenylatecyclase-inhibitingopioidreceptorsignalingpathwaypositiveregulationofangiogenesispositiveregulationofboneresorptionpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofosteoblastproliferationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofTcellmigrationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofactincytoskeletonorganizationregulationofboneresorptionregulationofextracellularmatrixorganizationregulationofpostsynapticneurotransmitterreceptorinternalizationregulationofproteinlocalizationregulationofproteintyrosinekinaseactivityregulationofreleaseofsequesteredcalciumionintocytosolregulationofserotoninuptakeregulationoftrophoblastcellmigrationresponsetoactivityresponsetoradiationsmoothmusclecellmigrationsubstrateadhesion-dependentcellspreadingtubedevelopmentviralentryintohostcellwoundhealing
Ribosomal oxygenase 1
150
60S ribosomal protein L8
220
1.9
70
0.75
RIOX1RL8Q9H6W3P62917chromatinorganizationhistoneH3-K36demethylationhistoneH3-K4demethylationnegativeregulationofosteoblastdifferentiationnegativeregulationoftranscriptionDNA-templatedcytoplasmictranslationtranslation
Glutamate receptor ionotropic, NMDA 1
810
Glutamate receptor ionotropic, NMDA 2B
321
2.0
45
1.09
NMDZ1NMDE2P35439Q00960adultlocomotorybehaviorassociativelearningcalciumionhomeostasiscalciumiontransmembraneimportintocytosolcalciumiontransportcationtransmembranetransportcationtransportcellularcalciumionhomeostasiscellularresponsetomanganeseioncerebralcortexdevelopmentchemicalsynaptictransmissionconditionedtasteaversionexcitatorypostsynapticpotentialionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylong-termmemorymalematingbehaviormemorynegativeregulationofneuronapoptoticprocessneuromuscularprocessolfactorylearningponsmaturationpositiveregulationofapoptoticprocesspositiveregulationofcalciumiontransportintocytosolpositiveregulationofcelldeathpositiveregulationofcysteine-typeendopeptidaseactivitypositiveregulationofdendriticspinemaintenancepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofSchwanncellmigrationpositiveregulationofsynaptictransmissionglutamatergicpositiveregulationoftranscriptionbyRNApolymeraseIIprepulseinhibitionpropylenemetabolicprocessproteinheterotetramerizationproteinlocalizationtopostsynapticmembraneprotein-containingcomplexassemblyregulationofaxonogenesisregulationofcationtransmembranetransportregulationofcellcommunicationregulationofdendritemorphogenesisregulationoflong-termneuronalsynapticplasticityregulationofmembranepotentialregulationofneuronapoptoticprocessregulationofneuronalsynapticplasticityregulationofrespiratorygaseousexchangeregulationofsynapseassemblyregulationofsynapticplasticityresponsetoamineresponsetoamphetamineresponsetocalciumionresponsetoethanolresponsetofungicideresponsetoglycineresponsetomorphineresponsetoorganiccycliccompoundrhythmicprocesssensoryperceptionofpainsocialbehaviorstartleresponsesucklingbehaviorsynaptictransmissionglutamatergicvisuallearningactionpotentialbehavioralfearresponsebehavioralresponsetopaincellularresponsetoaminoacidstimuluscellularresponsetocorticosteronestimuluscellularresponsetocurcumincellularresponsetodsRNAcellularresponsetoforskolincellularresponsetogrowthfactorstimuluscellularresponsetolipidcellularresponsetomagnesiumstarvationcellularresponsetoorganiccycliccompounddetectionofmechanicalstimulusinvolvedinsensoryperceptionofpainfearresponsehippocampusdevelopmentinuteroembryonicdevelopmentlong-termsynapticpotentiationmulticellularorganismalresponsetostressnegativeregulationofdendriticspinemaintenanceNMDAselectiveglutamatereceptorsignalingpathwaypositiveregulationofglutamatesecretionpositiveregulationofneurondeathpositiveregulationofsynaptictransmissionreceptorclusteringregulationofMAPKcascaderegulationofpostsynapticcytosoliccalciumionconcentrationregulationofpostsynapticmembranepotentialregulationofproteinkinaseAsignalingresponsetocarbohydrateresponsetococaineresponsetocytokineresponsetoelectricalstimulusresponsetogrowthhormoneresponsetohypoxiaresponsetomagnesiumionresponsetomanganeseionresponsetomechanicalstimulusresponsetomethylmercuryresponsetoorganonitrogencompoundresponsetootherorganismresponsetotoxicsubstancesensitizationsensoryorgandevelopment
Ras GTPase-activating-like protein IQGAP1
161
Ras GTPase-activating-like protein IQGAP1
161
2.0
45
1.09
IQGA1IQGA1P46940P46940cellmigrationcellularresponsetocalciumioncellularresponsetoepidermalgrowthfactorstimuluscellularresponsetoplatelet-derivedgrowthfactorstimulusepidermalgrowthfactorreceptorsignalingpathwayfibroblastgrowthfactorreceptorsignalingpathwayfibroblastmigrationnegativeregulationofdephosphorylationneuronprojectionextensionplatelet-derivedgrowthfactorreceptorsignalingpathwaypodocytedevelopmentpositiveregulationofMAPKcascadepositiveregulationofproteinkinaseactivityregulationofactincytoskeletonorganizationregulationofcytokineproductionregulationofGTPaseactivityregulationofmitoticcellcyclesignaltransduction
Immunoglobulin lambda variable 2-8
215
Immunoglobulin lambda variable 2-8
215
2.3
30
1.47
LV208LV208P01709P01709adaptiveimmuneresponseimmuneresponse
Amyloid-beta precursor protein
291
Amyloid-beta precursor protein
341
2.0
55
0.89
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofcellularresponsetothapsigarginpositiveregulationofcellularresponsetotunicamycinpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofcellularproteinmetabolicprocessregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Integrin alpha-V
401
Integrin beta-8
601
2.0
66
0.74
ITAVITB8P06756P26012angiogenesisapolipoproteinA-I-mediatedsignalingpathwayapoptoticcellclearancecalciumiontransmembranetransportcelladhesioncelladhesionmediatedbyintegrincellmigrationcell-celladhesioncell-matrixadhesioncell-substrateadhesionendodermalcelldifferentiationentryintohostcellbyasymbiont-containingvacuoleERK1andERK2cascadeextrinsicapoptoticsignalingpathwayinabsenceofligandheterotypiccell-celladhesionintegrin-mediatedsignalingpathwaynegativechemotaxisnegativeregulationofentryofbacteriumintohostcellnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationoflipidstoragenegativeregulationoflipidtransportnegativeregulationoflipoproteinmetabolicprocessnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofintracellularsignaltransductionpositiveregulationofosteoblastproliferationpositiveregulationofsmallGTPasemediatedsignaltransductionregulationofphagocytosisregulationoftransforminggrowthfactorbetaactivationsubstrateadhesion-dependentcellspreadingtransforminggrowthfactorbetaproductionvasculogenesisviralentryintohostcellcartilagedevelopmentgangliosidemetabolicprocesshardpalatedevelopmentimmuneresponseLangerhanscelldifferentiationnegativeregulationofgeneexpressionplacentabloodvesseldevelopmentpositiveregulationofangiogenesispositiveregulationofgeneexpressionresponsetovirustransforminggrowthfactorbetareceptorsignalingpathway
Egl nine homolog 1
317
Hypoxia-inducible factor 1-alpha
780
2.0
67
0.74
EGLN1HIF1AQ9GZT9Q16665cardiacmuscletissuemorphogenesiscellularironionhomeostasiscellularresponsetohypoxiahearttrabeculaformationlabyrinthinelayerdevelopmentnegativeregulationofcyclic-nucleotidephosphodiesteraseactivitynegativeregulationofDNA-bindingtranscriptionfactoractivityoxygenhomeostasispeptidyl-prolinehydroxylationto4-hydroxy-L-prolinepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofangiogenesisregulationofneurondeathregulationofpostsynapseorganizationregulationofproteincatabolicprocessatpostsynapsemodulatingsynaptictransmissionresponsetohypoxiaresponsetonitricoxideventricularseptummorphogenesisangiogenesisaxonaltransportofmitochondrionB-1Bcellhomeostasisbonemineralizationcardiacventriclemorphogenesiscellularglucosehomeostasiscellularresponsetointerleukin-1cellularresponsetoviruscerebralcortexdevelopmentchondrocytedifferentiationcollagenmetabolicprocessconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingdigestivetractmorphogenesisdopaminergicneurondifferentiationelastinmetabolicprocessembryonichemopoiesisembryonicplacentadevelopmentepithelialcelldifferentiationinvolvedinmammaryglandalveolusdevelopmentepithelialtomesenchymaltransitionglandularepithelialcellmaturationheartloopinghemoglobinbiosyntheticprocesshypoxia-induciblefactor-1alphasignalingpathwayinsulinsecretioninvolvedincellularresponsetoglucosestimulusintestinalepithelialcellmaturationirismorphogenesislactatemetabolicprocesslactationmesenchymalcellapoptoticprocessmusclecellcellularhomeostasisnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofgrowthnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofthymocyteapoptoticprocessnegativeregulationofTORsignalingneuralcrestcellmigrationneuralfoldelevationformationneuroblastproliferationneuronapoptoticprocessoutflowtractmorphogenesispositiveregulationofangiogenesispositiveregulationofautophagyofmitochondrionpositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofchemokineproductionpositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellmigrationpositiveregulationoferythrocytedifferentiationpositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhormonebiosyntheticprocesspositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofmacroautophagypositiveregulationofmiRNAtranscriptionpositiveregulationofneuroblastproliferationpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofsignalingreceptoractivitypositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofaerobicrespirationregulationofgeneexpressionregulationofglycolyticprocessregulationofproteinneddylationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetooxidativestressregulationoftranscriptionDNA-templatedregulationoftransforminggrowthfactorbeta2productionresponsetoironionresponsetomuscleactivityresponsetoreactiveoxygenspeciesretinavasculaturedevelopmentincamera-typeeyesignaltransductionTORsignalingvascularendothelialgrowthfactorproductionvisuallearning
Immunoglobulin heavy constant gamma 1
112
Immunoglobulin heavy constant gamma 1
349
2.0
66
0.74
IGHG1IGHG1P01857P01857adaptiveimmuneresponseantibody-dependentcellularcytotoxicityBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Insulin
109
Insulin
22
2.0
nan
nan
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
Glutamate receptor ionotropic, NMDA 1
561
Glutamate receptor ionotropic, NMDA 2B
1006
2.0
37
1.33
NMDZ1NMDE2P35439Q00960adultlocomotorybehaviorassociativelearningcalciumionhomeostasiscalciumiontransmembraneimportintocytosolcalciumiontransportcationtransmembranetransportcationtransportcellularcalciumionhomeostasiscellularresponsetomanganeseioncerebralcortexdevelopmentchemicalsynaptictransmissionconditionedtasteaversionexcitatorypostsynapticpotentialionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylong-termmemorymalematingbehaviormemorynegativeregulationofneuronapoptoticprocessneuromuscularprocessolfactorylearningponsmaturationpositiveregulationofapoptoticprocesspositiveregulationofcalciumiontransportintocytosolpositiveregulationofcelldeathpositiveregulationofcysteine-typeendopeptidaseactivitypositiveregulationofdendriticspinemaintenancepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofSchwanncellmigrationpositiveregulationofsynaptictransmissionglutamatergicpositiveregulationoftranscriptionbyRNApolymeraseIIprepulseinhibitionpropylenemetabolicprocessproteinheterotetramerizationproteinlocalizationtopostsynapticmembraneprotein-containingcomplexassemblyregulationofaxonogenesisregulationofcationtransmembranetransportregulationofcellcommunicationregulationofdendritemorphogenesisregulationoflong-termneuronalsynapticplasticityregulationofmembranepotentialregulationofneuronapoptoticprocessregulationofneuronalsynapticplasticityregulationofrespiratorygaseousexchangeregulationofsynapseassemblyregulationofsynapticplasticityresponsetoamineresponsetoamphetamineresponsetocalciumionresponsetoethanolresponsetofungicideresponsetoglycineresponsetomorphineresponsetoorganiccycliccompoundrhythmicprocesssensoryperceptionofpainsocialbehaviorstartleresponsesucklingbehaviorsynaptictransmissionglutamatergicvisuallearningactionpotentialbehavioralfearresponsebehavioralresponsetopaincellularresponsetoaminoacidstimuluscellularresponsetocorticosteronestimuluscellularresponsetocurcumincellularresponsetodsRNAcellularresponsetoforskolincellularresponsetogrowthfactorstimuluscellularresponsetolipidcellularresponsetomagnesiumstarvationcellularresponsetoorganiccycliccompounddetectionofmechanicalstimulusinvolvedinsensoryperceptionofpainfearresponsehippocampusdevelopmentinuteroembryonicdevelopmentlong-termsynapticpotentiationmulticellularorganismalresponsetostressnegativeregulationofdendriticspinemaintenanceNMDAselectiveglutamatereceptorsignalingpathwaypositiveregulationofglutamatesecretionpositiveregulationofneurondeathpositiveregulationofsynaptictransmissionreceptorclusteringregulationofMAPKcascaderegulationofpostsynapticcytosoliccalciumionconcentrationregulationofpostsynapticmembranepotentialregulationofproteinkinaseAsignalingresponsetocarbohydrateresponsetococaineresponsetocytokineresponsetoelectricalstimulusresponsetogrowthhormoneresponsetohypoxiaresponsetomagnesiumionresponsetomanganeseionresponsetomechanicalstimulusresponsetomethylmercuryresponsetoorganonitrogencompoundresponsetootherorganismresponsetotoxicsubstancesensitizationsensoryorgandevelopment
Integrin alpha-V
400
Integrin beta-6
604
2.0
65
0.76
ITAVITB6P06756P18564angiogenesisapolipoproteinA-I-mediatedsignalingpathwayapoptoticcellclearancecalciumiontransmembranetransportcelladhesioncelladhesionmediatedbyintegrincellmigrationcell-celladhesioncell-matrixadhesioncell-substrateadhesionendodermalcelldifferentiationentryintohostcellbyasymbiont-containingvacuoleERK1andERK2cascadeextrinsicapoptoticsignalingpathwayinabsenceofligandheterotypiccell-celladhesionintegrin-mediatedsignalingpathwaynegativechemotaxisnegativeregulationofentryofbacteriumintohostcellnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationoflipidstoragenegativeregulationoflipidtransportnegativeregulationoflipoproteinmetabolicprocessnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofintracellularsignaltransductionpositiveregulationofosteoblastproliferationpositiveregulationofsmallGTPasemediatedsignaltransductionregulationofphagocytosisregulationoftransforminggrowthfactorbetaactivationsubstrateadhesion-dependentcellspreadingtransforminggrowthfactorbetaproductionvasculogenesisviralentryintohostcellbonedevelopmentbronchioledevelopmentcellmorphogenesiscellularresponsetoionizingradiationenamelmineralizationhardpalatedevelopmentimmuneresponseinflammatoryresponseLangerhanscelldifferentiationlungalveolusdevelopmentphospholipidhomeostasisresponsetovirusskindevelopmentSMADproteinsignaltransductionsurfactanthomeostasistransforminggrowthfactorbetareceptorsignalingpathwaywoundhealing
Integrin alpha-V
401
Integrin beta-6
604
2.0
68
0.72
ITAVITB6P06756P18564angiogenesisapolipoproteinA-I-mediatedsignalingpathwayapoptoticcellclearancecalciumiontransmembranetransportcelladhesioncelladhesionmediatedbyintegrincellmigrationcell-celladhesioncell-matrixadhesioncell-substrateadhesionendodermalcelldifferentiationentryintohostcellbyasymbiont-containingvacuoleERK1andERK2cascadeextrinsicapoptoticsignalingpathwayinabsenceofligandheterotypiccell-celladhesionintegrin-mediatedsignalingpathwaynegativechemotaxisnegativeregulationofentryofbacteriumintohostcellnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationoflipidstoragenegativeregulationoflipidtransportnegativeregulationoflipoproteinmetabolicprocessnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofintracellularsignaltransductionpositiveregulationofosteoblastproliferationpositiveregulationofsmallGTPasemediatedsignaltransductionregulationofphagocytosisregulationoftransforminggrowthfactorbetaactivationsubstrateadhesion-dependentcellspreadingtransforminggrowthfactorbetaproductionvasculogenesisviralentryintohostcellbonedevelopmentbronchioledevelopmentcellmorphogenesiscellularresponsetoionizingradiationenamelmineralizationhardpalatedevelopmentimmuneresponseinflammatoryresponseLangerhanscelldifferentiationlungalveolusdevelopmentphospholipidhomeostasisresponsetovirusskindevelopmentSMADproteinsignaltransductionsurfactanthomeostasistransforminggrowthfactorbetareceptorsignalingpathwaywoundhealing
Potassium channel subfamily K member 2
108
Potassium channel subfamily K member 2
108
2.0
38
1.3
KCNK2KCNK2P97438P97438cardiacventricledevelopmentcellularresponsetohypoxiacochleadevelopmentGprotein-coupledreceptorsignalingpathwaymemorynegativeregulationofcardiacmusclecellproliferationnegativeregulationofDNAbiosyntheticprocesspositiveregulationofcelldeathpositiveregulationofcellularresponsetohypoxiapotassiumiontransmembranetransportpotassiumiontransportregulationofmembranepotentialresponsetoaxoninjuryresponsetomechanicalstimulusstabilizationofmembranepotential
Bifunctional peptidase and arginyl-hydroxylase JMJD5
308
RCC1 domain-containing protein 1
139
2.0
nan
nan
KDM8RCCD1Q8N371A6NED2chromatinorganizationcircadianregulationofgeneexpressionG2/MtransitionofmitoticcellcyclehistoneH3-K36demethylationnegativeregulationoftranscriptionDNA-templatedpositiveregulationoftranscriptionDNA-templatedproteindestabilizationproteolysis
Egl nine homolog 1
201
Hypoxia-inducible factor 1-alpha
780
2.0
82
0.6
EGLN1HIF1AQ9GZT9Q16665cardiacmuscletissuemorphogenesiscellularironionhomeostasiscellularresponsetohypoxiahearttrabeculaformationlabyrinthinelayerdevelopmentnegativeregulationofcyclic-nucleotidephosphodiesteraseactivitynegativeregulationofDNA-bindingtranscriptionfactoractivityoxygenhomeostasispeptidyl-prolinehydroxylationto4-hydroxy-L-prolinepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofangiogenesisregulationofneurondeathregulationofpostsynapseorganizationregulationofproteincatabolicprocessatpostsynapsemodulatingsynaptictransmissionresponsetohypoxiaresponsetonitricoxideventricularseptummorphogenesisangiogenesisaxonaltransportofmitochondrionB-1Bcellhomeostasisbonemineralizationcardiacventriclemorphogenesiscellularglucosehomeostasiscellularresponsetointerleukin-1cellularresponsetoviruscerebralcortexdevelopmentchondrocytedifferentiationcollagenmetabolicprocessconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingdigestivetractmorphogenesisdopaminergicneurondifferentiationelastinmetabolicprocessembryonichemopoiesisembryonicplacentadevelopmentepithelialcelldifferentiationinvolvedinmammaryglandalveolusdevelopmentepithelialtomesenchymaltransitionglandularepithelialcellmaturationheartloopinghemoglobinbiosyntheticprocesshypoxia-induciblefactor-1alphasignalingpathwayinsulinsecretioninvolvedincellularresponsetoglucosestimulusintestinalepithelialcellmaturationirismorphogenesislactatemetabolicprocesslactationmesenchymalcellapoptoticprocessmusclecellcellularhomeostasisnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofgrowthnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofthymocyteapoptoticprocessnegativeregulationofTORsignalingneuralcrestcellmigrationneuralfoldelevationformationneuroblastproliferationneuronapoptoticprocessoutflowtractmorphogenesispositiveregulationofangiogenesispositiveregulationofautophagyofmitochondrionpositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofchemokineproductionpositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellmigrationpositiveregulationoferythrocytedifferentiationpositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhormonebiosyntheticprocesspositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofmacroautophagypositiveregulationofmiRNAtranscriptionpositiveregulationofneuroblastproliferationpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofsignalingreceptoractivitypositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofaerobicrespirationregulationofgeneexpressionregulationofglycolyticprocessregulationofproteinneddylationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetooxidativestressregulationoftranscriptionDNA-templatedregulationoftransforminggrowthfactorbeta2productionresponsetoironionresponsetomuscleactivityresponsetoreactiveoxygenspeciesretinavasculaturedevelopmentincamera-typeeyesignaltransductionTORsignalingvascularendothelialgrowthfactorproductionvisuallearning
Beta-2-microglobulin
33
Beta-2-microglobulin
33
2.1
78
0.6
B2MGB2MGP61769P61769amyloidfibrilformationantibacterialhumoralresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofexogenousproteinantigenviaMHCclassIbTAP-dependentantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetoironioncellularresponsetoiron(III)ioncellularresponsetolipopolysaccharidecellularresponsetonicotinedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseironionhomeostasisironiontransportlearningormemorynegativeregulationofepithelialcellproliferationnegativeregulationofforebrainneurondifferentiationnegativeregulationofneurogenesisnegativeregulationofneuronprojectiondevelopmentnegativeregulationofreceptorbindingpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofcellularsenescencepositiveregulationofferrousironbindingpositiveregulationofproteinbindingpositiveregulationofreceptorbindingpositiveregulationofreceptor-mediatedendocytosispositiveregulationofTcellactivationpositiveregulationofTcellcytokineproductionpositiveregulationofTcellmediatedcytotoxicitypositiveregulationoftransferrinreceptorbindingproteinhomotetramerizationproteinrefoldingregulationoferythrocytedifferentiationregulationofironiontransportregulationofmembranedepolarizationresponsetomoleculeofbacterialoriginretinahomeostasissensoryperceptionofsmellTcelldifferentiationinthymusTcellmediatedcytotoxicity
H-2 class II histocompatibility antigen, A-D alpha chain
74
Insulin-1
107
3.0
nan
nan
HA2DINS1P04228P01325adaptiveimmuneresponseantigenprocessingandpresentationantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofpeptideantigennegativeregulationofTcellproliferationpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivationpositiveregulationofTcelldifferentiationglucosehomeostasisglucosemetabolicprocessglucosetransmembranetransportpositiveregulationofproteinsecretionresponsetocAMPresponsetocytokineresponsetopeptidehormone
Integrin alpha-V
969
Integrin beta-3
643
2.0
nan
nan
ITAVITB3P06756P05106angiogenesisapolipoproteinA-I-mediatedsignalingpathwayapoptoticcellclearancecalciumiontransmembranetransportcelladhesioncelladhesionmediatedbyintegrincellmigrationcell-celladhesioncell-matrixadhesioncell-substrateadhesionendodermalcelldifferentiationentryintohostcellbyasymbiont-containingvacuoleERK1andERK2cascadeextrinsicapoptoticsignalingpathwayinabsenceofligandheterotypiccell-celladhesionintegrin-mediatedsignalingpathwaynegativechemotaxisnegativeregulationofentryofbacteriumintohostcellnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationoflipidstoragenegativeregulationoflipidtransportnegativeregulationoflipoproteinmetabolicprocessnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofintracellularsignaltransductionpositiveregulationofosteoblastproliferationpositiveregulationofsmallGTPasemediatedsignaltransductionregulationofphagocytosisregulationoftransforminggrowthfactorbetaactivationsubstrateadhesion-dependentcellspreadingtransforminggrowthfactorbetaproductionvasculogenesisviralentryintohostcellactivationofproteinkinaseactivityangiogenesisinvolvedinwoundhealingbloodcoagulationcell-substratejunctionassemblycellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetomechanicalstimuluscellularresponsetoplatelet-derivedgrowthfactorstimuluscellularresponsetoxenobioticstimulusembryoimplantationmesodermalcelldifferentiationnegativeregulationofcelldeathplateletactivationplateletaggregationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofadenylatecyclase-inhibitingopioidreceptorsignalingpathwaypositiveregulationofangiogenesispositiveregulationofboneresorptionpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofTcellmigrationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofactincytoskeletonorganizationregulationofboneresorptionregulationofextracellularmatrixorganizationregulationofpostsynapticneurotransmitterreceptorinternalizationregulationofproteinlocalizationregulationofproteintyrosinekinaseactivityregulationofreleaseofsequesteredcalciumionintocytosolregulationofserotoninuptakeregulationoftrophoblastcellmigrationresponsetoactivityresponsetoradiationsmoothmusclecellmigrationtubedevelopmentwoundhealing
T cell receptor alpha chain constant
156
T cell receptor beta constant 1
167
2.0
78
0.63
TRACTRBC1P01848P01850adaptiveimmuneresponsealpha-betaTcellactivationresponsetobacteriumTcellreceptorsignalingpathwayBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Bcl-2 homologous antagonist/killer
184
BH3-interacting domain death agonist
104
2.1
nan
nan
BAKBIDQ16611P55957activationofcysteine-typeendopeptidaseactivityactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessbycytochromecaginganimalorganregenerationapoptoticprocessapoptoticprocessinvolvedinbloodvesselmorphogenesisapoptoticsignalingpathwayBcellapoptoticprocessBcellhomeostasisBcellnegativeselectionbloodvesselremodelingbraindevelopmentcalciumiontransportintocytosolcellularresponsetomechanicalstimuluscellularresponsetounfoldedproteincellularresponsetoUVendocrinepancreasdevelopmentendoplasmicreticulumcalciumionhomeostasisepithelialcellproliferationestablishmentormaintenanceoftransmembraneelectrochemicalgradientextrinsicapoptoticsignalingpathwayinabsenceofligandfibroblastapoptoticprocessintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstresslimbmorphogenesismitochondrialfusionmyeloidcellhomeostasisnegativeregulationofcellpopulationproliferationnegativeregulationofendoplasmicreticulumcalciumionconcentrationnegativeregulationofgeneexpressionnegativeregulationofmitochondrialoutermembranepermeabilizationinvolvedinapoptoticsignalingpathwaynegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofreleaseofcytochromecfrommitochondriapeptidyl-serinephosphorylationpositiveregulationofapoptoticprocesspositiveregulationofcalciumiontransportintocytosolpositiveregulationofendoplasmicreticulumunfoldedproteinresponsepositiveregulationofIRE1-mediatedunfoldedproteinresponsepositiveregulationofmitochondrialoutermembranepermeabilizationinvolvedinapoptoticsignalingpathwaypositiveregulationofprotein-containingcomplexassemblypositiveregulationofproteolysispositiveregulationofreleaseofcytochromecfrommitochondriapost-embryoniccamera-typeeyemorphogenesisregulationofcellcycleregulationofmitochondrialmembranepermeabilityregulationofmitochondrialmembranepotentialreleaseofcytochromecfrommitochondriaresponsetoethanolresponsetofungusresponsetogammaradiationresponsetohydrogenperoxideresponsetomycotoxinresponsetoorganiccycliccompoundresponsetoUV-Cresponsetoxenobioticstimulusthymocyteapoptoticprocessvaginadevelopmentactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticmitochondrialchangesestablishmentofproteinlocalizationtomembraneextrinsicapoptoticsignalingpathwayviadeathdomainreceptorshepatocyteapoptoticprocessmitochondrialATPsynthesiscoupledelectrontransportmitochondrialoutermembranepermeabilizationnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageneuronapoptoticprocesspositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationoffibroblastapoptoticprocesspositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofmitochondrialmembranepotentialproteintargetingtomitochondrionprotein-containingcomplexassemblyregulationofepithelialcellproliferationregulationofG1/StransitionofmitoticcellcycleregulationofTcellproliferationsignaltransductioninresponsetoDNAdamagesupramolecularfiberorganization
T cell receptor alpha chain constant
160
T cell receptor beta constant 2
170
2.0
79
0.62
TRACTRBC2P01848A0A5B9adaptiveimmuneresponsealpha-betaTcellactivationresponsetobacteriumTcellreceptorsignalingpathwayBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Peroxiredoxin-1
185
Sulfiredoxin-1
43
2.1
56
0.86
PRDX1SRXN1Q06830Q9BYN0cellpopulationproliferationcellredoxhomeostasiserythrocytehomeostasisfibroblastproliferationhydrogenperoxidecatabolicprocessleukocyteactivationnaturalkillercellactivationnaturalkillercellmediatedcytotoxicityregulationofNIK/NF-kappaBsignalingregulationofstress-activatedMAPKcascaderemovalofsuperoxideradicalsretinahomeostasisskeletalsystemdevelopmentcellularresponsetooxidativestressresponsetooxidativestress
Bcl-2 homologous antagonist/killer
184
Bcl-2 homologous antagonist/killer
92
2.0
nan
nan
BAKBAKQ16611Q16611activationofcysteine-typeendopeptidaseactivityactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessbycytochromecaginganimalorganregenerationapoptoticprocessapoptoticprocessinvolvedinbloodvesselmorphogenesisapoptoticsignalingpathwayBcellapoptoticprocessBcellhomeostasisBcellnegativeselectionbloodvesselremodelingbraindevelopmentcalciumiontransportintocytosolcellularresponsetomechanicalstimuluscellularresponsetounfoldedproteincellularresponsetoUVendocrinepancreasdevelopmentendoplasmicreticulumcalciumionhomeostasisepithelialcellproliferationestablishmentormaintenanceoftransmembraneelectrochemicalgradientextrinsicapoptoticsignalingpathwayinabsenceofligandfibroblastapoptoticprocessintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstresslimbmorphogenesismitochondrialfusionmyeloidcellhomeostasisnegativeregulationofcellpopulationproliferationnegativeregulationofendoplasmicreticulumcalciumionconcentrationnegativeregulationofgeneexpressionnegativeregulationofmitochondrialoutermembranepermeabilizationinvolvedinapoptoticsignalingpathwaynegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofreleaseofcytochromecfrommitochondriapeptidyl-serinephosphorylationpositiveregulationofapoptoticprocesspositiveregulationofcalciumiontransportintocytosolpositiveregulationofendoplasmicreticulumunfoldedproteinresponsepositiveregulationofIRE1-mediatedunfoldedproteinresponsepositiveregulationofmitochondrialoutermembranepermeabilizationinvolvedinapoptoticsignalingpathwaypositiveregulationofprotein-containingcomplexassemblypositiveregulationofproteolysispositiveregulationofreleaseofcytochromecfrommitochondriapost-embryoniccamera-typeeyemorphogenesisregulationofcellcycleregulationofmitochondrialmembranepermeabilityregulationofmitochondrialmembranepotentialreleaseofcytochromecfrommitochondriaresponsetoethanolresponsetofungusresponsetogammaradiationresponsetohydrogenperoxideresponsetomycotoxinresponsetoorganiccycliccompoundresponsetoUV-Cresponsetoxenobioticstimulusthymocyteapoptoticprocessvaginadevelopment
T cell receptor beta constant 1
175
T cell receptor alpha chain constant
163
2.0
75
0.66
TRBC1TRACP01850P01848adaptiveimmuneresponsealpha-betaTcellactivationBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationTcellreceptorsignalingpathwayresponsetobacterium
T cell receptor alpha chain constant
162
T cell receptor beta constant 1
169
2.0
74
0.67
TRACTRBC1P01848P01850adaptiveimmuneresponsealpha-betaTcellactivationresponsetobacteriumTcellreceptorsignalingpathwayBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
MHC class II HLA-DQ-alpha chain
72
HLA class II histocompatibility antigen DQ beta chain
-15
2.2
59
0.76
Q30069U3PYM0Q30069U3PYM0adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
T cell receptor alpha chain constant
164
T cell receptor beta constant 2
168
2.1
73
0.67
TRACTRBC2P01848A0A5B9adaptiveimmuneresponsealpha-betaTcellactivationresponsetobacteriumTcellreceptorsignalingpathwayBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Bifunctional peptidase and arginyl-hydroxylase JMJD5
275
40S ribosomal protein S6
138
2.0
nan
nan
KDM8RS6Q8N371P62753chromatinorganizationcircadianregulationofgeneexpressionG2/MtransitionofmitoticcellcyclehistoneH3-K36demethylationnegativeregulationoftranscriptionDNA-templatedpositiveregulationoftranscriptionDNA-templatedproteindestabilizationproteolysisactivation-inducedcelldeathofTcellscytoplasmictranslationerythrocytedevelopmentG1/StransitionofmitoticcellcyclegastrulationglucosehomeostasismammalianoogenesisstagenegativeregulationofapoptoticprocessplacentadevelopmentpositiveregulationofapoptoticprocesspositiveregulationofcellpopulationproliferationribosomalsmallsubunitbiogenesisrRNAprocessingTcelldifferentiationinthymusTcellproliferationinvolvedinimmuneresponseTORsignalingtranslation
T cell receptor alpha chain constant
158
T cell receptor beta constant 1
171
2.0
73
0.67
TRACTRBC1P01848P01850adaptiveimmuneresponsealpha-betaTcellactivationresponsetobacteriumTcellreceptorsignalingpathwayBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Polyubiquitin-C
nan
Ubiquitin-conjugating enzyme E2 N
87
2.0
nan
nan
UBCUBE2NP0CG48P61088modification-dependentproteincatabolicprocessproteinubiquitinationDNAdouble-strandbreakprocessingdouble-strandbreakrepairviahomologousrecombinationhistoneubiquitinationpositiveregulationofDNArepairpositiveregulationofdouble-strandbreakrepairpositiveregulationofhistonemodificationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofintracellularsignaltransductionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteinK63-linkedubiquitinationpositiveregulationofubiquitin-proteintransferaseactivitypostreplicationrepairproteinK63-linkedubiquitinationproteinpolyubiquitinationregulationofDNArepairregulationofhistoneubiquitinationTcellreceptorsignalingpathwayubiquitin-dependentproteincatabolicprocess
Polyubiquitin-B
nan
Histone H3.3
18
2.0
nan
nan
J3QS39H33J3QS39P84243cellpopulationproliferationDNAreplication-independentchromatinassemblyembryoimplantationhistoneH3-S10phosphorylationhistoneH3-T3phosphorylationinvolvedinchromosomepassengercomplexlocalizationtokinetochoremalegonaddevelopmentmulticellularorganismgrowthmusclecelldifferentiationnegativeregulationofchromosomecondensationnucleosomeassemblynucleusorganizationoocytematurationosteoblastdifferentiationpericentricheterochromatinassemblypositiveregulationofcellgrowthregulationofcentromerecomplexassemblysinglefertilizationspermatiddevelopmentsubtelomericheterochromatinassemblytelomereorganization
Podoplanin
nan
Podoplanin
nan
2.0
nan
nan
PDPNPDPNQ86YL7Q86YL7actin-mediatedcellcontractioncellmigrationcellmorphogenesiscell-celladhesionlungdevelopmentlymphnodedevelopmentlymphangiogenesislymphaticendothelialcellfatecommitmentnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationplateletactivationpositiveregulationofcellmigrationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofextracellularmatrixdisassemblypositiveregulationofplateletaggregationregulationofcellshaperegulationoflamellipodiummorphogenesisregulationofmyofibroblastcontractionregulationofsubstrateadhesion-dependentcellspreadingresponsetohyperoxiaRhoproteinsignaltransductionwoundhealingspreadingofcells
Beta-2-microglobulin
20
Beta-2-microglobulin
20
2.0
58
0.85
B2MGB2MGP61769P61769amyloidfibrilformationantibacterialhumoralresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofexogenousproteinantigenviaMHCclassIbTAP-dependentantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetoironioncellularresponsetoiron(III)ioncellularresponsetolipopolysaccharidecellularresponsetonicotinedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseironionhomeostasisironiontransportlearningormemorynegativeregulationofepithelialcellproliferationnegativeregulationofforebrainneurondifferentiationnegativeregulationofneurogenesisnegativeregulationofneuronprojectiondevelopmentnegativeregulationofreceptorbindingpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofcellularsenescencepositiveregulationofferrousironbindingpositiveregulationofproteinbindingpositiveregulationofreceptorbindingpositiveregulationofreceptor-mediatedendocytosispositiveregulationofTcellactivationpositiveregulationofTcellcytokineproductionpositiveregulationofTcellmediatedcytotoxicitypositiveregulationoftransferrinreceptorbindingproteinhomotetramerizationproteinrefoldingregulationoferythrocytedifferentiationregulationofironiontransportregulationofmembranedepolarizationresponsetomoleculeofbacterialoriginretinahomeostasissensoryperceptionofsmellTcelldifferentiationinthymusTcellmediatedcytotoxicity
Retinol-binding protein 2
32
Retinol-binding protein 2
32
2.1
70
0.69
RET2RET2P50120P50120epidermisdevelopmentfattyacidtransportvitaminAmetabolicprocess
Galectin-7
16
Galectin-7
16
1.9
69
0.76
LEG7LEG7P47929P47929apoptoticprocessheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesnegativeregulationofCD4-positivealpha-betaTcellproliferationnegativeregulationofinterferon-gammaproductionpositiveregulationofgeneexpression
Neutrophil defensin 1
1
Neutrophil defensin 1
1
2.0
nan
nan
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismmodificationbyhostofsymbiontmembraneTcellchemotaxis
T cell receptor alpha variable 4
158
T cell receptor beta variable 9
174
2.0
76
0.65
TVA4TVB9A0A0B4J268A0A0B4J1U6adaptiveimmuneresponseresponsetobacteriumcellsurfacereceptorsignalingpathway
Polyubiquitin-B
46
Polyubiquitin-B
46
2.0
48
1.02
UBBUBBP0CG47P0CG47energyhomeostasisfatpaddevelopmentfemalegonaddevelopmentfemalemeiosisIhypothalamusgonadotrophin-releasinghormoneneurondevelopmentmalemeiosisImitochondriontransportalongmicrotubulemodification-dependentproteincatabolicprocessneuronprojectionmorphogenesispositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofproteinmonoubiquitinationpositiveregulationofproteinubiquitinationproteinubiquitinationregulationofmitochondrialmembranepotentialregulationofneurondeathregulationofproteasomalproteincatabolicprocessseminiferoustubuledevelopment
T cell receptor alpha variable 4
162
T cell receptor beta variable 28
170
2.0
75
0.66
TVA4TVB28A0A0B4J268A0A5B6adaptiveimmuneresponseresponsetobacteriumcellsurfacereceptorsignalingpathway
Vimentin
265
Vimentin
265
2.0
38
1.29
VIMEVIMEP08670P08670astrocytedevelopmentBergmannglialcelldifferentiationcellularresponsetointerferon-gammacellularresponsetolipopolysaccharidecellularresponsetomuramyldipeptideintermediatefilamentorganizationlensfibercelldevelopmentnegativeregulationofneuronprojectiondevelopmentneuronprojectiondevelopmentpositiveregulationofcollagenbiosyntheticprocesspositiveregulationoftranslationregulationofmRNAstabilitySMADproteinsignaltransduction
T cell receptor alpha chain constant
163
T cell receptor beta constant 1
174
2.0
74
0.66
TRACTRBC1P01848P01850adaptiveimmuneresponsealpha-betaTcellactivationresponsetobacteriumTcellreceptorsignalingpathwayBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Ubiquitin-40S ribosomal protein S27a
76
Histone H3.1
18
2.0
nan
nan
RS27AH31P62979P68431cytoplasmictranslationmodification-dependentproteincatabolicprocessproteinubiquitinationtranslationDNAreplication-dependentchromatinassemblynucleosomeassemblyregulationofgeneexpressionepigenetictelomereorganization
Immunoglobulin heavy constant epsilon
335
Immunoglobulin heavy constant epsilon
335
2.0
43
1.15
IGHEIGHEP01854P01854adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Beta-2-microglobulin
50
Beta-2-microglobulin
50
2.0
58
0.85
B2MGB2MGP61769P61769amyloidfibrilformationantibacterialhumoralresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofexogenousproteinantigenviaMHCclassIbTAP-dependentantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetoironioncellularresponsetoiron(III)ioncellularresponsetolipopolysaccharidecellularresponsetonicotinedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseironionhomeostasisironiontransportlearningormemorynegativeregulationofepithelialcellproliferationnegativeregulationofforebrainneurondifferentiationnegativeregulationofneurogenesisnegativeregulationofneuronprojectiondevelopmentnegativeregulationofreceptorbindingpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofcellularsenescencepositiveregulationofferrousironbindingpositiveregulationofproteinbindingpositiveregulationofreceptorbindingpositiveregulationofreceptor-mediatedendocytosispositiveregulationofTcellactivationpositiveregulationofTcellcytokineproductionpositiveregulationofTcellmediatedcytotoxicitypositiveregulationoftransferrinreceptorbindingproteinhomotetramerizationproteinrefoldingregulationoferythrocytedifferentiationregulationofironiontransportregulationofmembranedepolarizationresponsetomoleculeofbacterialoriginretinahomeostasissensoryperceptionofsmellTcelldifferentiationinthymusTcellmediatedcytotoxicity
LIM domain-binding protein 1
56
LIM domain-binding protein 1
56
2.0
57
0.87
LDB1LDB1P70662P70662anterior/posterioraxisspecificationcelladhesioncelldifferentiationcellularcomponentassemblycerebellarPurkinjecelldifferentiationcerebellumdevelopmentepithelialstructuremaintenancegastrulationwithmouthformingsecondhairfollicledevelopmentheaddevelopmenthistoneH3-K4acetylationmesendodermdevelopmentnegativeregulationoferythrocytedifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatednervoussystemdevelopmentneurondifferentiationpositiveregulationofcelladhesionpositiveregulationofhemoglobinbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprimitiveerythrocytedifferentiationregulationofcellmigrationregulationoffocaladhesionassemblyregulationofkinaseactivityregulationoftranscriptionelongationfromRNApolymeraseIIpromotersomaticstemcellpopulationmaintenancetranscriptionbyRNApolymeraseIItranscription-dependenttetheringofRNApolymeraseIIgeneDNAatnuclearperipheryWntsignalingpathway
Cytochrome c oxidase assembly factor 6 homolog
59
Cytochrome c oxidase assembly factor 6 homolog
59
2.0
67
0.73
COA6COA6Q5JTJ3Q5JTJ3mitochondrialATPsynthesiscoupledelectrontransportplasmamembraneATPsynthesiscoupledelectrontransportrespiratorychaincomplexIVassembly
T cell receptor gamma variable 8
177
T cell receptor delta variable 3
169
2.0
73
0.67
TRGV8TRDV3A0A0C4DH27A0JD37adaptiveimmuneresponseinnateimmuneresponseimmuneresponse
Insulin
10
Insulin
4
1.9
48
1.07
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
H-2 class II histocompatibility antigen, A-D alpha chain
64
H2-Ab1 protein
-19
2.0
78
0.63
HA2DQ31135P04228Q31135adaptiveimmuneresponseantigenprocessingandpresentationantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofpeptideantigennegativeregulationofTcellproliferationpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivationpositiveregulationofTcelldifferentiation
MHC class II HLA-DQ-alpha chain
72
MHC class II HLA-DQ-beta-1
11
2.0
53
0.93
Q30069O19707Q30069O19707adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Ig-like domain-containing protein
166
Ig-like domain-containing protein
168
2.1
74
0.65
Q6PIR9Q7TND8Q6PIR9Q7TND8
Ribonuclease pancreatic
32
Ribonuclease pancreatic
31
2.0
63
0.77
RNAS1RNAS1P07998P07998defenseresponsetoGram-positivebacteriumRNAphosphodiesterbondhydrolysis
MHC class II HLA-DQ-alpha chain
72
MHC class II antigen
11
2.0
58
0.84
Q30069A0A6B9KAL0Q30069A0A6B9KAL0adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Ribosomal oxygenase 2
209
60S ribosomal protein L27a
37
2.0
53
0.93
RIOX2RL27AQ8IUF8P46776histoneH3-K36demethylationhistoneH3-K4demethylationribosomebiogenesiscytoplasmictranslationtranslation
C-C motif chemokine 20
64
C-C motif chemokine 20
64
2.0
68
0.73
CCL20CCL20P78556P78556antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecalcium-mediatedsignalingusingintracellularcalciumsourcecellchemotaxiscell-cellsignalingcellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisdefenseresponsetobacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofTcellmigrationsignaltransductionTcellmigrationthymocytemigration
Tryptase alpha/beta-1
99
Tryptase alpha/beta-1
99
2.0
62
0.8
TRYB1TRYB1Q15661Q15661defenseresponseextracellularmatrixdisassemblyproteolysis
T-cell receptor alpha chain C region
166
T-cell receptor beta-1 chain C region
168
2.0
72
0.68
TCATCB1P01849P01852proteinhomotetramerizationresponsetobacteriumTcelllineagecommitmentBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Heat shock cognate 71 kDa protein
171
Putative tyrosine-protein phosphatase auxilin
876
2.0
68
0.72
HSP7CAUXIP19120Q27974cellularresponsetounfoldedproteinchaperonecofactor-dependentproteinrefoldingchaperone-mediatedautophagytranslocationcomplexdisassemblylateendosomalmicroautophagymRNAprocessingnegativeregulationoftranscriptionDNA-templatedproteinrefoldingproteintargetingtolysosomeinvolvedinchaperone-mediatedautophagyRNAsplicingslowaxonaltransportsynapticvesicleuncoatingvesicle-mediatedtransportclathrincoatdisassemblyclathrin-dependentendocytosisdephosphorylation
T-cell receptor alpha chain C region
166
T-cell receptor beta-2 chain C region
168
2.0
75
0.65
TCATCB2P01849P01851proteinhomotetramerizationresponsetobacteriumTcelllineagecommitmentBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Immunoglobulin heavy constant epsilon
329
Immunoglobulin heavy constant epsilon
329
2.0
nan
nan
IGHEIGHEP01854P01854adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
C-X-C chemokine receptor type 2
47
C-X-C chemokine receptor type 2
47
2.0
73
0.67
CXCR2CXCR2P25025P25025acuteinflammatoryresponsetoantigenicstimuluscalcium-mediatedsignalingcellchemotaxiscellsurfacereceptorsignalingpathwaycellulardefenseresponsechemotaxisdendriticcellchemotaxisimmuneresponseinflammatoryresponseinterleukin-8-mediatedsignalingpathwaymetanephrictubulemorphogenesismidbraindevelopmentnegativeregulationofneutrophilapoptoticprocessneutrophilactivationneutrophilchemotaxisphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofangiogenesispositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofneutrophilchemotaxispositiveregulationofvascularpermeabilityreceptorinternalizationsignaltransduction
Mitogen-activated protein kinase 1
116
Tyrosine-protein phosphatase non-receptor type 7
31
2.0
nan
nan
MK01PTN7P63086P35236aginganimalorganmorphogenesisapoptoticprocessBcellreceptorsignalingpathwayBergmannglialcelldifferentiationcardiacneuralcrestcelldevelopmentinvolvedinheartdevelopmentcaveolin-mediatedendocytosiscellcyclecellsurfacereceptorsignalingpathwaycellularresponsetoaminoacidstarvationcellularresponsetocadmiumioncellularresponsetoDNAdamagestimuluscellularresponsetodopaminecellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimuluscellularresponsetoorganicsubstancecellularresponsetoreactiveoxygenspeciescellularresponsetotumornecrosisfactorcytosinemetabolicprocessdecidualizationdiadenosinetetraphosphatebiosyntheticprocessERBBsignalingpathwayERK1andERK2cascadefacedevelopmentheartdevelopmentintracellularsignaltransductionlabyrinthinelayerbloodvesseldevelopmentlipopolysaccharide-mediatedsignalingpathwaylong-termsynapticpotentiationlungmorphogenesismammaryglandepithelialcellproliferationMAPKcascadenegativeregulationofcelldifferentiationneuralcrestcelldevelopmentouterearmorphogenesispeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofmacrophagechemotaxispositiveregulationofmacrophageproliferationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationoftelomeraseactivitypositiveregulationoftelomerecappingpositiveregulationoftelomeremaintenanceviatelomerasepositiveregulationoftranscriptionDNA-templatedpositiveregulationoftranslationproteinphosphorylationregulationofcellularpHregulationofcytoskeletonorganizationregulationofearlyendosometolateendosometransportregulationofGolgiinheritanceregulationofossificationregulationofproteinstabilityregulationofstress-activatedMAPKcascaderesponsetoepidermalgrowthfactorresponsetoestrogenresponsetoexogenousdsRNAresponsetolipopolysaccharideresponsetonicotineresponsetotoxicsubstancesensoryperceptionofpainsignaltransductionstress-activatedMAPKcascadeTcellreceptorsignalingpathwaythymusdevelopmentthyroidglanddevelopmenttracheaformationproteindephosphorylation
Prothrombin
336
Thrombomodulin
134
2.1
82
0.58
THRBTRBMP00734P07204acute-phaseresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidebloodcoagulationbloodcoagulationcommonpathwaycellsurfacereceptorsignalingpathwaycytolysisbyhostofsymbiontcellsfibrinolysisnegativeregulationofastrocytedifferentiationnegativeregulationofbloodcoagulationnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationoffibrinolysisnegativeregulationofplateletactivationnegativeregulationofproteolysisneutrophil-mediatedkillingofgram-negativebacteriumplateletactivationpositiveregulationofbloodcoagulationpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationoflipidkinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinphosphorylationpositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofreleaseofsequesteredcalciumionintocytosolproteolysisregulationofbloodcoagulationregulationofcellshaperegulationofcytosoliccalciumionconcentrationresponsetowoundingzymogenactivationfemalepregnancyresponsetocAMPresponsetolipopolysaccharideresponsetoX-ray
Lectin-related NK cell receptor LY49L4
107
Lectin-related NK cell receptor LY49L4
107
2.1
36
1.33
Q9JIP9Q9JIP9Q9JIP9Q9JIP9
Hepatocyte growth factor-like protein
468
Hepatocyte growth factor-like protein
588
2.1
nan
nan
HGFLHGFLP26927P26927histoneH2A-S139phosphorylationnegativeregulationofgluconeogenesisproteolysisregulationofcAMP-dependentproteinkinaseactivityregulationofreceptorsignalingpathwayviaJAK-STAT
Fibrinogen alpha chain
47
Fibrinogen alpha chain
47
2.0
33
1.49
FIBAFIBAP02671P02671adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumion
Suppressor of tumorigenicity 14 protein
731
Suppressor of tumorigenicity 14 protein
604
2.0
nan
nan
ST14ST14Q9Y5Y6Q9Y5Y6epithelialcellmorphogenesisinvolvedinplacentalbranchingkeratinocytedifferentiationneuraltubeclosureproteincatabolicprocessproteolysis
Ribosomal protein S6 kinase alpha-1
575
Ribosomal protein S6 kinase alpha-1
575
2.0
49
1.02
KS6A1KS6A1Q15418Q15418cellcyclechemicalsynaptictransmissionhepatocyteproliferationintracellularsignaltransductionnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspeptidyl-serinephosphorylationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofhepaticstellatecellactivationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofDNA-templatedtranscriptioninresponsetostressregulationoftranslationinresponsetostresssignaltransduction
Receptor-interacting serine/threonine-protein kinase 2
7
Receptor-interacting serine/threonine-protein kinase 2
7
2.0
47
1.04
RIPK2RIPK2O43353O43353activationofcysteine-typeendopeptidaseactivityadaptiveimmuneresponseapoptoticprocessCD4-positivealpha-betaTcellproliferationcellularresponsetolipoteichoicacidcellularresponsetomuramyldipeptidecellularresponsetopeptidoglycancytokine-mediatedsignalingpathwaydefenseresponsetoGram-positivebacteriumERK1andERK2cascadeI-kappaBkinase/NF-kappaBsignalingimmatureTcellproliferationinthymusinflammatoryresponseinnateimmuneresponseJNKcascadelipopolysaccharide-mediatedsignalingpathwaynucleotide-bindingoligomerizationdomaincontaining1signalingpathwaynucleotide-bindingoligomerizationdomaincontaining2signalingpathwaypositiveregulationofapoptoticprocesspositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcelldeathpositiveregulationofchemokineproductionpositiveregulationofcytokine-mediatedsignalingpathwaypositiveregulationofERK1andERK2cascadepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofimmatureTcellproliferationinthymuspositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationofmacrophagecytokineproductionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinubiquitinationpositiveregulationofT-helper1celldifferentiationpositiveregulationofT-helper1typeimmuneresponsepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationofxenophagyresponsetoexogenousdsRNAresponsetointerleukin-1responsetointerleukin-12responsetointerleukin-18signaltransductionTcellreceptorsignalingpathwaytoll-likereceptor2signalingpathwaytoll-likereceptor4signalingpathwayxenophagy
Amyloid beta precursor like protein 2
310
Amyloid beta precursor like protein 2
360
2.1
nan
nan
APLP2APLP2Q06481Q06481axonogenesiscentralnervoussystemdevelopmentGprotein-coupledreceptorsignalingpathwayregulationofcellularproteinmetabolicprocess
Human nkt tcr beta chain
176
TRA@ protein
167
2.0
71
0.69
K7N5M4Q6PJ56K7N5M4Q6PJ56
Tubulinyl-Tyr carboxypeptidase 2
158
Tubulin alpha-1B chain
450
2.1
79
0.61
VASH2TBA1BQ86V25P68363axondevelopmentcell-cellfusionlabyrinthinelayerbloodvesseldevelopmentpositiveregulationofangiogenesispositiveregulationofendothelialcellproliferationproteolysisregulationofangiogenesissyncytiumformationbyplasmamembranefusioncelldivisioncellularresponsetointerleukin-4cytoskeleton-dependentintracellulartransportmicrotubulecytoskeletonorganizationmicrotubule-basedprocessmitoticcellcycle
ATPase WRNIP1
39
ATPase WRNIP1
39
2.0
37
1.33
WRIP1WRIP1Q96S55Q96S55DNAsynthesisinvolvedinDNArepairDNA-templatedDNAreplicationinnateimmuneresponseregulationofDNArepairregulationofDNA-templatedDNAreplicationinitiation
Interleukin-18
104
Interleukin-18
104
2.0
61
0.81
IL18IL18Q14116Q14116activationofproteinkinaseBactivityangiogenesiscellpopulationproliferationcell-cellsignalingcellularresponsetoorganiccycliccompoundcholesterolhomeostasisdefenseresponsetoGram-positivebacteriumestablishmentofskinbarrierinflammatoryresponseinterleukin-18-mediatedsignalingpathwaylipopolysaccharide-mediatedsignalingpathwayMAPKcascadenaturalkillercellactivationnaturalkillercellmediatedcytotoxicitynegativeregulationofmyoblastdifferentiationneutrophilactivationNIK/NF-kappaBsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofchemokineproductionpositiveregulationofcold-inducedthermogenesispositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-13productionpositiveregulationofinterleukin-17productionpositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofnaturalkillercellproliferationpositiveregulationofneuroinflammatoryresponsepositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofNKTcellproliferationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofsmoothmusclecellproliferationpositiveregulationofT-helper1cellcytokineproductionpositiveregulationofT-helper2celldifferentiationpositiveregulationoftissueremodelingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofcelladhesionsleepT-helper1typeimmuneresponsetriglyceridehomeostasistype2immuneresponse
Protein NDRG3
30
Protein NDRG3
30
2.0
56
0.88
NDRG3NDRG3Q9UGV2Q9UGV2celldifferentiationnegativeregulationofcellgrowthsignaltransductionspermatogenesis
TRA@ protein
161
Human nkt tcr beta chain
176
2.0
77
0.64
Q6IRV4K7N5M4Q6IRV4K7N5M4
Thioredoxin reductase 1, cytoplasmic
533
Thioredoxin
32
2.0
73
0.67
TRXR1THIOQ16881P10599cellpopulationproliferationcellredoxhomeostasismesodermformationsignaltransductionactivationofproteinkinaseBactivitynegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiation
Haptoglobin
33
Haptoglobin
33
2.0
nan
nan
HPTHPTP00738P00738acuteinflammatoryresponseacute-phaseresponsedefenseresponsedefenseresponsetobacteriumimmunesystemprocessnegativeregulationofhydrogenperoxidecatabolicprocessnegativeregulationofoxidoreductaseactivitypositiveregulationofcelldeathresponsetohydrogenperoxidezymogenactivation
NACHT, LRR and PYD domains-containing protein 12
11
NACHT, LRR and PYD domains-containing protein 12
11
2.0
75
0.65
NAL12NAL12P59046P59046activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesscellularresponsetocytokinestimulusdendriticcellmigrationERK1andERK2cascadenegativeregulationofcytokineproductionnegativeregulationofERK1andERK2cascadenegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-1productionnegativeregulationofinterleukin-6productionnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofNIK/NF-kappaBsignalingnegativeregulationofproteinautophosphorylationnegativeregulationofsignaltransductionnegativeregulationofTollsignalingpathwayNIK/NF-kappaBsignalingpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofMHCclassIbiosyntheticprocesspositiveregulationofNIK/NF-kappaBsignalingregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessregulationofI-kappaBkinase/NF-kappaBsignalingregulationofinflammatoryresponseregulationofinterleukin-18productionsignaltransduction
Myotrophin
2
Myotrophin
2
2.0
58
0.84
MTPNMTPNP58546P58546catecholaminemetabolicprocesscellularresponsetomechanicalstimuluscerebellargranulecelldifferentiationneurondifferentiationpositiveregulationofcardiacmusclehypertrophypositiveregulationofcellgrowthpositiveregulationofmacromoleculebiosyntheticprocesspositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteinmetabolicprocessregulationofbarbed-endactinfilamentcappingregulationofcellsizeregulationofstriatedmuscletissuedevelopmentregulationoftranslationskeletalmuscletissueregenerationstriatedmusclecelldifferentiation
Integrin beta-4
1629
Dystonin
1082
2.0
46
1.06
ITB4DYSTP16144Q03001autophagycelladhesioncelladhesionmediatedbyintegrincellmigrationcellmotilitycell-matrixadhesionfilopodiumassemblyhemidesmosomeassemblyintegrin-mediatedsignalingpathwaymesodermalcelldifferentiationnaildevelopmentperipheralnervoussystemmyelinformationresponsetowoundingskinmorphogenesistrophoblastcellmigrationcytoplasmicmicrotubuleorganizationcytoskeletonorganizationintermediatefilamentcytoskeletonorganizationmaintenanceofcellpolaritymicrotubulecytoskeletonorganizationretrogradeaxonaltransportwoundhealing
Haptoglobin
33
Haptoglobin
33
2.0
nan
nan
HPTHPTQ8SPS7Q8SPS7acuteinflammatoryresponseacute-phaseresponsedefenseresponsetobacteriumimmunesystemprocesspositiveregulationofcelldeathzymogenactivation
T-cell surface glycoprotein CD3 epsilon chain
122
T-cell surface glycoprotein CD3 delta chain
93
2.0
40
1.23
CD3ECD3DP07766P04234adaptiveimmuneresponsealpha-betaTcellactivationapoptoticsignalingpathwaycalcium-mediatedsignalingCD4-positivealpha-betaTcellproliferationcellsurfacereceptorsignalingpathwaycerebellumdevelopmentdendritedevelopmentGprotein-coupledreceptorsignalingpathwaygamma-deltaTcellactivationnegativeregulationofgeneexpressionnegativeregulationofsmoothenedsignalingpathwaynegativethymicTcellselectionpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofgeneexpressionpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofTcellanergypositiveregulationofTcellproliferationpositivethymicTcellselectionprotein-containingcomplexassemblyregulationofapoptoticprocesssignalcomplexassemblysmoothenedsignalingpathwayTcellactivationTcellanergyTcellcostimulationTcellreceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathway
Cartilage oligomeric matrix protein
71
Cartilage oligomeric matrix protein
68
2.0
nan
nan
COMPCOMPQ9R0G6Q9R0G6apoptoticprocessarterymorphogenesisbloodcoagulationBMPsignalingpathwaybonegrowthbonemineralizationbonemorphogenesiscartilagedevelopmentcartilagehomeostasischondrocytedevelopmentchondrocyteproliferationcollagenfibrilorganizationendochondralbonegrowthgrowthplatecartilagedevelopmentlimbdevelopmentmulticellularorganismagingmulticellularorganismgrowthmusclecelldevelopmentmusculoskeletalmovementnegativeregulationofapoptoticprocessnegativeregulationofhemostasisneuromuscularprocessossificationplateletaggregationpositiveregulationofchondrocyteproliferationproteinhomooligomerizationproteinprocessingproteinsecretionregulationofbonemineralizationregulationofgeneexpressionresponsetounfoldedproteinskeletalsystemdevelopmentskindevelopmenttendondevelopmentvascularassociatedsmoothmusclecelldevelopmentvascularassociatedsmoothmusclecontraction
Transcription regulator protein BACH2
125
Transcription regulator protein BACH2
125
2.0
53
0.93
BACH2BACH2Q9BYV9Q9BYV9importintonucleusnegativeregulationoftranscriptionbyRNApolymeraseIIprimaryadaptiveimmuneresponseinvolvingTcellsandBcellsregulationoftranscriptionbyRNApolymeraseII
Baculoviral IAP repeat-containing protein 3
28
Baculoviral IAP repeat-containing protein 3
28
2.3
59
0.73
BIRC3BIRC3Q13489Q13489cellsurfacereceptorsignalingpathwayI-kappaBkinase/NF-kappaBsignalingnegativeregulationofapoptoticprocessnegativeregulationofnecroptoticprocessNIK/NF-kappaBsignalingpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofproteinubiquitinationregulationofapoptoticprocessregulationofcellcycleregulationofcysteine-typeendopeptidaseactivityregulationofinflammatoryresponseregulationofinnateimmuneresponseregulationofnecroptoticprocessregulationofnucleotide-bindingoligomerizationdomaincontainingsignalingpathwayregulationofRIG-Isignalingpathwayregulationoftoll-likereceptorsignalingpathwayspermatogenesistumornecrosisfactor-mediatedsignalingpathway
Immunoglobulin lambda constant 1
105
Immunoglobulin heavy constant gamma 1
103
2.1
nan
nan
IGLC1IGHG1P01842P01857adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationantibody-dependentcellularcytotoxicitycomplement-dependentcytotoxicity
Protein FEV
135
Protein FEV
135
3.0
53
0.64
FEVFEVQ99581Q99581celldifferentiationneuronfatespecificationneuronmaturationpositiveregulationofgeneexpressionregulationoftranscriptionbyRNApolymeraseII
Protein disulfide-isomerase A6
55
Peroxiredoxin-4
248
2.1
50
0.97
PDIA6PRDX4Q15084O08807proteinfoldingresponsetoendoplasmicreticulumstresscellredoxhomeostasisextracellularmatrixorganizationmalegonaddevelopmentnegativeregulationofmalegermcellproliferationpeptidyl-prolinehydroxylationto4-hydroxy-L-prolineproteinmaturationbyproteinfoldingreactiveoxygenspeciesmetabolicprocessresponsetooxidativestressspermatogenesis
Serine/threonine-protein kinase MARK2
210
Serine/threonine-protein kinase MARK2
210
2.1
50
0.97
MARK2MARK2O08679O08679axondevelopmentestablishmentofcellpolarityestablishmentormaintenanceofcellpolarityregulatingcellshapeestablishmentormaintenanceofepithelialcellapical/basalpolarityintracellularsignaltransductionmicrotubulecytoskeletonorganizationneuronmigrationpeptidyl-serinephosphorylationpositiveregulationofneuronprojectiondevelopmentproteinautophosphorylationproteinphosphorylationregulationofaxonogenesisregulationofcytoskeletonorganizationregulationofmicrotubulebindingregulationofmicrotubulecytoskeletonorganizationWntsignalingpathway
Urokinase-type plasminogen activator
168
Urokinase-type plasminogen activator
299
2.0
nan
nan
UROKUROKQ5SWW9Q5SWW9bloodcoagulationchemotaxisfibrinolysisnegativeregulationoffibrinolysisnegativeregulationofplasminogenactivationplasminogenactivationpositiveregulationofcellmigrationproteolysisregulationofcelladhesionregulationofcelladhesionmediatedbyintegrinregulationofcellpopulationproliferationregulationoffibrinolysisregulationofplasminogenactivationregulationofsignalingreceptoractivityregulationofsmoothmusclecellmigrationregulationofsmoothmusclecell-matrixadhesionregulationofwoundhealingresponsetohypoxiasignaltransductionsmoothmusclecellmigrationurokinaseplasminogenactivatorsignalingpathway
Serine/threonine-protein kinase 10
206
Serine/threonine-protein kinase 10
206
2.0
41
1.19
STK10STK10O94804O94804cellcyclelymphocyteaggregationproteinautophosphorylationproteinphosphorylationregulationoflymphocytemigration
Ral guanine nucleotide dissociation stimulator
780
Ral guanine nucleotide dissociation stimulator
780
2.0
59
0.83
GNDSGNDSQ03386Q03386positiveregulationofGTPaseactivityRasproteinsignaltransductionsmallGTPasemediatedsignaltransduction
Cytotoxic T-lymphocyte protein 4
157
Cytotoxic T-lymphocyte protein 4
157
2.0
29
1.69
CTLA4CTLA4P16410P16410adaptiveimmuneresponseBcellreceptorsignalingpathwaycellularresponsetoDNAdamagestimulusimmuneresponsenegativeregulationofBcellproliferationnegativeregulationofimmuneresponsenegativeregulationofregulatoryTcelldifferentiationnegativeregulationofTcellproliferationpositiveregulationofapoptoticprocessTcellreceptorsignalingpathway
T cell receptor alpha chain constant
163
Human nkt tcr beta chain
176
2.1
74
0.66
TRACK7N5M4P01848K7N5M4adaptiveimmuneresponsealpha-betaTcellactivationresponsetobacteriumTcellreceptorsignalingpathway
Resistin-like beta
25
Resistin-like beta
25
2.0
nan
nan
RETNBRETNBQ99P86Q99P86responsetobacterium
Integrin alpha-2
169
Integrin alpha-2
169
2.0
63
0.78
ITA2ITA2P17301P17301animalorganmorphogenesisbloodcoagulationcelladhesioncelladhesionmediatedbyintegrincellpopulationproliferationcell-celladhesioncell-matrixadhesioncell-substrateadhesioncellularresponsetoestradiolstimuluscellularresponsetomechanicalstimuluscollagen-activatedsignalingpathwaydetectionofmechanicalstimulusinvolvedinsensoryperceptionofpainestablishmentofproteinlocalizationfemalepregnancyfocaladhesionassemblyhepatocytedifferentiationhypotonicresponseintegrin-mediatedsignalingpathwaymammaryglanddevelopmentmesodermalcelldifferentiationpositiveregulationofalkalinephosphataseactivitypositiveregulationofcelladhesionpositiveregulationofcellprojectionorganizationpositiveregulationofcollagenbindingpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofDNAbindingpositiveregulationofepithelialcellmigrationpositiveregulationofinflammatoryresponsepositiveregulationofleukocytemigrationpositiveregulationofphagocytosisengulfmentpositiveregulationofpositivechemotaxispositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsmoothmusclecontractionpositiveregulationoftranslationpositiveregulationoftransmissionofnerveimpulseresponsetoamineresponsetohypoxiaresponsetoL-ascorbicacidresponsetomuscleactivityresponsetoparathyroidhormoneresponsetoxenobioticstimulusskinmorphogenesissubstrate-dependentcellmigration
Immunoglobulin heavy constant gamma 1
109
Immunoglobulin heavy constant gamma 1
109
2.0
nan
nan
IGHG1IGHG1P01857P01857adaptiveimmuneresponseantibody-dependentcellularcytotoxicityBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Myocilin
171
Myocilin
171
2.0
nan
nan
MYOCMYOCO70624O70624bonedevelopmentclusteringofvoltage-gatedsodiumchannelsERBB2-ERBB3signalingpathwaymyelinationinperipheralnervoussystemnegativeregulationofcell-matrixadhesionnegativeregulationofRhoproteinsignaltransductionnegativeregulationofstressfiberassemblyneuronprojectiondevelopmentnon-canonicalWntsignalingpathwayviaJNKcascadeosteoblastdifferentiationpositiveregulationofcellmigrationpositiveregulationoffocaladhesionassemblypositiveregulationofmitochondrialdepolarizationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofstressfiberassemblypositiveregulationofsubstrateadhesion-dependentcellspreadingregulationofMAPKcascadesignaltransductionskeletalmusclehypertrophy
Major prion protein
179
Major prion protein
214
2.0
54
0.91
PRIOPRIOP04156P04156activationofproteinkinaseactivitycalcium-mediatedsignalingusingintracellularcalciumsourcecellcyclecellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocopperioncellularresponsetoxenobioticstimulusdendriticspinemaintenancelearningormemorylong-termmemorynegativeregulationofactivatedTcellproliferationnegativeregulationofamyloidprecursorproteincatabolicprocessnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofcalcineurin-NFATsignalingcascadenegativeregulationofdendriticspinemaintenancenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofinterferon-gammaproductionnegativeregulationofinterleukin-17productionnegativeregulationofinterleukin-2productionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofproteinphosphorylationnegativeregulationofproteinprocessingnegativeregulationofTcellreceptorsignalingpathwayneuronprojectionmaintenancepositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteintargetingtomembranepositiveregulationofproteintyrosinekinaseactivityproteindestabilizationproteinhomooligomerizationregulationofcalciumionimportacrossplasmamembraneregulationofglutamatereceptorsignalingpathwayregulationofintracellularcalciumactivatedchloridechannelactivityregulationofpeptidyl-tyrosinephosphorylationregulationofpotassiumiontransmembranetransportresponsetoamyloid-betaresponsetocadmiumionresponsetooxidativestress
Leukocyte elastase inhibitor
344
Leukocyte elastase inhibitor
344
2.0
35
1.4
ILEUILEUP30740P30740negativeregulationofendopeptidaseactivitynegativeregulationofinterleukin-1betaproductiontypeBpancreaticcellproliferation
Translationally-controlled tumor protein
172
Translationally-controlled tumor protein
172
2.1
50
0.95
TCTPTCTPP13693P13693calciumiontransportcellularcalciumionhomeostasisnegativeregulationofapoptoticprocessnegativeregulationofectodermdevelopmentnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageregulationofapoptoticprocessresponsetovirusstemcellpopulationmaintenance
Immunoglobulin gamma-1 heavy chain
231
Immunoglobulin gamma-1 heavy chain
231
2.0
nan
nan
IGG1IGG1P0DOX5P0DOX5adaptiveimmuneresponse
T cell receptor alpha chain constant
157
Human nkt tcr beta chain
176
2.0
71
0.69
TRACK7N5M4P01848K7N5M4adaptiveimmuneresponsealpha-betaTcellactivationresponsetobacteriumTcellreceptorsignalingpathway
E3 ubiquitin-protein ligase RNF31
885
E3 ubiquitin-protein ligase RNF31
885
2.1
nan
nan
RNF31RNF31Q96EP0Q96EP0CD40signalingpathwaydefenseresponsetobacteriumnegativeregulationofnecroptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteintargetingtomitochondrionpositiveregulationofxenophagyproteinlinearpolyubiquitinationproteinpolyubiquitinationTcellreceptorsignalingpathway
Annexin A2
262
Annexin A2
262
2.7
38
0.98
ANXA2ANXA2P07355P07355angiogenesiscollagenfibrilorganizationfibrinolysismembraneraftassemblymRNAtranscriptionbyRNApolymeraseIInegativeregulationoflow-densitylipoproteinparticlereceptorcatabolicprocessnegativeregulationofreceptorinternalizationosteoclastdevelopmentpositiveregulationofexocytosispositiveregulationoflow-densitylipoproteinparticleclearancepositiveregulationoflow-densitylipoproteinparticlereceptorbindingpositiveregulationoflow-densitylipoproteinreceptoractivitypositiveregulationofplasmamembranerepairpositiveregulationofplasminogenactivationpositiveregulationofreceptorrecyclingpositiveregulationofreceptor-mediatedendocytosisinvolvedincholesteroltransportpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvacuoleorganizationpositiveregulationofvesiclefusionregulationofneurogenesisvesiclebuddingfrommembrane
Glutamate receptor ionotropic, NMDA 2B
946
Glutamate receptor ionotropic, NMDA 2B
946
2.0
53
0.93
NMDE2NMDE2Q00960Q00960actionpotentialassociativelearningbehavioralfearresponsebehavioralresponsetopaincalciumiontransmembraneimportintocytosolcalciumiontransportcationtransmembranetransportcationtransportcellularresponsetoaminoacidstimuluscellularresponsetocorticosteronestimuluscellularresponsetocurcumincellularresponsetodsRNAcellularresponsetoforskolincellularresponsetogrowthfactorstimuluscellularresponsetolipidcellularresponsetomagnesiumstarvationcellularresponsetomanganeseioncellularresponsetoorganiccycliccompoundcerebralcortexdevelopmentchemicalsynaptictransmissiondetectionofmechanicalstimulusinvolvedinsensoryperceptionofpainexcitatorypostsynapticpotentialfearresponsehippocampusdevelopmentinuteroembryonicdevelopmentionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylong-termmemorylong-termsynapticpotentiationmemorymulticellularorganismalresponsetostressnegativeregulationofdendriticspinemaintenanceNMDAselectiveglutamatereceptorsignalingpathwaypositiveregulationofcelldeathpositiveregulationofcysteine-typeendopeptidaseactivitypositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofglutamatesecretionpositiveregulationofneurondeathpositiveregulationofsynaptictransmissionpositiveregulationofsynaptictransmissionglutamatergicproteinheterotetramerizationreceptorclusteringregulationofcationtransmembranetransportregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofneuronalsynapticplasticityregulationofpostsynapticcytosoliccalciumionconcentrationregulationofpostsynapticmembranepotentialregulationofproteinkinaseAsignalingregulationofsynapticplasticityresponsetoamineresponsetoamphetamineresponsetocalciumionresponsetocarbohydrateresponsetococaineresponsetocytokineresponsetoelectricalstimulusresponsetoethanolresponsetofungicideresponsetogrowthhormoneresponsetohypoxiaresponsetomagnesiumionresponsetomanganeseionresponsetomechanicalstimulusresponsetomethylmercuryresponsetoorganiccycliccompoundresponsetoorganonitrogencompoundresponsetootherorganismresponsetotoxicsubstancerhythmicprocesssensitizationsensoryorgandevelopmentstartleresponsesucklingbehavior
Mitochondrial Rho GTPase 2
470
Mitochondrial Rho GTPase 2
470
2.0
74
0.66
MIRO2MIRO2Q8IXI1Q8IXI1cellularhomeostasismitochondrialoutermembranepermeabilizationmitochondrionorganizationmitochondriontransportalongmicrotubuleregulationofmitochondrionorganizationsmallGTPasemediatedsignaltransduction
Laminin subunit alpha-5
529
Laminin subunit gamma-1
852
2.1
69
0.68
LAMA5LAMC1O15230P11047animalorganmorphogenesisaxonguidancebranchinginvolvedinsalivaryglandmorphogenesisbranchinginvolvedinuretericbudmorphogenesiscellmigrationcell-celladhesionciliumassemblyhairfollicledevelopmentintegrin-mediatedsignalingpathwaylungdevelopmentmorphogenesisofapolarizedepitheliummorphogenesisofembryonicepitheliummuscleorgandevelopmentodontogenesisofdentin-containingtoothproteinlocalizationtoplasmamembraneregulationofcelladhesionregulationofcellmigrationregulationofembryonicdevelopmentregulationofepithelialcellproliferationsubstrateadhesion-dependentcellspreadingtissuedevelopmenttrunkneuralcrestcellmigrationcelladhesionendodermdevelopmentextracellularmatrixdisassemblyhemidesmosomeassemblymaintenanceofblood-brainbarrierpositiveregulationofcelladhesionpositiveregulationofepithelialcellproliferationpositiveregulationofintegrin-mediatedsignalingpathwaypositiveregulationofmusclecelldifferentiationprotein-containingcomplexassemblyregulationofbasementmembraneorganization
Protein phosphatase 3 catalytic subunit alpha
336
Calcipressin-1
216
2.0
nan
nan
PP2BARCAN1Q08209P53805agingbraindevelopmentcalcineurin-mediatedsignalingcalcineurin-NFATsignalingcascadecalciumiontransportcardiacmusclehypertrophyinresponsetostresscellularresponsetoglucosestimulusdendritemorphogenesisdephosphorylationepidermisdevelopmentexcitatorypostsynapticpotentialG1/StransitionofmitoticcellcyclekeratinocytedifferentiationmodulationofchemicalsynaptictransmissionmulticellularorganismalresponsetostressnegativeregulationofcalciumionimportacrossplasmamembranenegativeregulationofchromatinbindingnegativeregulationofdendritemorphogenesisnegativeregulationofinsulinsecretionnegativeregulationofmiRNAmaturationnegativeregulationofsignalingnegativeregulationofvoltage-gatedcalciumchannelactivitypeptidyl-serinedephosphorylationpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcalciumionimportacrossplasmamembranepositiveregulationofcardiacmusclehypertrophyinresponsetostresspositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofconnectivetissuereplacementpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendocytosispositiveregulationofglomerulusdevelopmentpositiveregulationofosteoblastdifferentiationpositiveregulationofosteoclastdifferentiationpositiveregulationofsalivasecretionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvoltage-gatedcalciumchannelactivitypostsynapticmodulationofchemicalsynaptictransmissionproteindephosphorylationproteinimportintonucleusregulationofcellproliferationinvolvedinkidneymorphogenesisrenalfiltrationresponsetoamphetamineresponsetocalciumionskeletalmusclefiberdevelopmentskeletalmuscletissueregenerationTcellactivationtransitionbetweenfastandslowfiberwoundhealingcalcium-mediatedsignalinglocomotioninvolvedinlocomotorybehaviornegativeregulationofcalcineurin-NFATsignalingcascaderegulationofphosphoproteinphosphataseactivityresponsetoischemiaresponsetooxidativestressshort-termmemory
Collagen alpha-1(III) chain
1196
Collagen alpha-1(III) chain
1464
2.0
nan
nan
CO3A1CO3A1P02461P02461aortasmoothmuscletissuemorphogenesisbasementmembraneorganizationcell-matrixadhesioncellularresponsetoaminoacidstimuluscerebralcortexdevelopmentchondrocytedifferentiationcollagenfibrilorganizationdigestivetractdevelopmentelasticfiberassemblyendochondralbonemorphogenesisextracellularmatrixorganizationfibroblastproliferationheartdevelopmentinuteroembryonicdevelopmentintegrin-mediatedsignalingpathwaylayerformationincerebralcortexlimbjointmorphogenesislungdevelopmentmulticellularorganismgrowthnegativeregulationofimmuneresponsenegativeregulationofneuronmigrationneuronmigrationpeptidecross-linkingplateletactivationpositiveregulationofRhoproteinsignaltransductionresponsetoangiotensinresponsetocytokineresponsetoradiationskindevelopmentsupramolecularfiberorganizationtissuehomeostasistransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbeta1productionwoundhealing
Insulin
7
Insulin
31
2.0
nan
nan
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
TRA@ protein
166
Human nkt tcr beta chain
176
2.1
70
0.69
Q2YD82K7N5M4Q2YD82K7N5M4
Mitochondrial import receptor subunit TOM20 homolog
100
Aldehyde dehydrogenase, mitochondrial
26
2.0
nan
nan
TOM20ALDH2Q62760P11884proteinimportintomitochondrialmatrixproteintargetingtomitochondrion"responseto335-triiodo-L-thyronine"responsetomuscleactivitytRNAimportintomitochondrionacetaldehydemetabolicprocessaldehydecatabolicprocessapoptoticmitochondrialchangesbehavioralresponsetoethanolcellulardetoxificationofaldehydecellularresponsetofattyacidcellularresponsetohormonestimuluscellularresponsetoresveratrolethanolcatabolicprocessethanolmetabolicprocessintrinsicapoptoticsignalingpathwayinresponsetooxidativestressliverdevelopmentnegativeregulationofapoptoticprocessregulationofdopaminebiosyntheticprocessregulationofinflammatoryresponseregulationofreactiveoxygenspeciesmetabolicprocessregulationofresponsetooxidativestressregulationofserotoninbiosyntheticprocessresponsetoestradiolresponsetoethanolresponsetoheatresponsetohyperoxiaresponsetoischemiaresponsetolipopolysaccharideresponsetonicotineresponsetoorganiccycliccompoundresponsetoprogesteroneresponsetotestosterone
Human nkt tcr alpha chain
164
T cell receptor beta constant 2
168
2.1
72
0.67
K7N5M3TRBC2K7N5M3A0A5B9adaptiveimmuneresponsealpha-betaTcellactivationBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationTcellreceptorsignalingpathway
Macrophage migration inhibitory factor
110
Macrophage migration inhibitory factor
81
2.0
81
0.61
MIFMIFP14174P14174carboxylicacidmetabolicprocesscellsurfacereceptorsignalingpathwaycellularsenescenceDNAdamageresponsesignaltransductionbyp53classmediatorinflammatoryresponseinnateimmuneresponsenegativeregulationofapoptoticprocessnegativeregulationofcellmigrationnegativeregulationofcellularsenescencenegativeregulationofDNAdamageresponsesignaltransductionbyp53classmediatornegativeregulationofgeneexpressionnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatornegativeregulationofmacrophagechemotaxisnegativeregulationofmatureBcellapoptoticprocessnegativeregulationofmyeloidcellapoptoticprocessnegativeregulationofproteinmetabolicprocesspositiveregulationofarachidonicacidsecretionpositiveregulationofBcellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofchemokine(C-X-Cmotif)ligand2productionpositiveregulationofcytokineproductionpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofMAPkinaseactivitypositiveregulationofmyeloidleukocytecytokineproductioninvolvedinimmuneresponsepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphorylationpositiveregulationofprostaglandinsecretioninvolvedinimmuneresponsepositiveregulationofproteinkinaseAsignalingpositiveregulationoftumornecrosisfactorproductionprostaglandinbiosyntheticprocessproteinhomotrimerizationregulationofmacrophageactivation
T-cell receptor, sp3.4 alpha chain
161
T cell receptor beta constant 1
168
2.1
84
0.58
K7N5N2TRBC1K7N5M9P01850adaptiveimmuneresponsealpha-betaTcellactivationBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationTcellreceptorsignalingpathway
Immunoglobulin lambda constant 1
105
Immunoglobulin heavy variable 3-33
221
2.0
33
1.49
IGLC1HV333P01842P01772adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Immunoglobulin heavy constant mu
215
Immunoglobulin heavy constant mu
215
2.0
nan
nan
IGHMIGHMP01873P01873adaptiveimmuneresponseantibacterialhumoralresponseantigenprocessingandpresentationBcellactivationBcellaffinitymaturationBcellproliferationBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumearlyendosometolateendosometransporthumoralimmuneresponsemediatedbycirculatingimmunoglobulinimmunoglobulinmediatedimmuneresponseinnateimmuneresponseMAPKcascadepeptidyl-tyrosinephosphorylationphagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofBcellproliferationpositiveregulationofendocytosispositiveregulationofimmuneresponsepositiveregulationofMAPKcascadepositiveregulationofpeptidyl-tyrosinephosphorylationregulationofcellmorphogenesisregulationofimmunoglobulinproduction
Superoxide dismutase [Cu-Zn]
201
Superoxide dismutase [Cu-Zn]
112
2.0
nan
nan
SODCSODCP00441P00441aginganterogradeaxonaltransportapoptoticprocessauditoryreceptorcellstereociliumorganizationcellularironionhomeostasiscellularresponsetoATPcellularresponsetocadmiumioncellularresponsetopotassiumionectopicgermcellprogrammedcelldeathembryoimplantationglutathionemetabolicprocessheartcontractionhydrogenperoxidebiosyntheticprocesslocomotorybehaviormusclecellcellularhomeostasismyeloidcellhomeostasisnegativeregulationofcholesterolbiosyntheticprocessnegativeregulationofdevelopmentalprocessnegativeregulationofinflammatoryresponsenegativeregulationofneuronapoptoticprocessnegativeregulationofreproductiveprocessneurofilamentcytoskeletonorganizationovarianfollicledevelopmentperipheralnervoussystemmyelinmaintenanceplacentadevelopmentpositiveregulationofapoptoticprocesspositiveregulationofcatalyticactivitypositiveregulationofcytokineproductionpositiveregulationofMAPKcascadepositiveregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaypositiveregulationofphagocytosispositiveregulationofsuperoxideaniongenerationreactiveoxygenspeciesmetabolicprocessregulationofbloodpressureregulationofGTPaseactivityregulationofmitochondrialmembranepotentialregulationofmulticellularorganismgrowthregulationoforgangrowthregulationofproteinkinaseactivityregulationofTcelldifferentiationinthymusrelaxationofvascularassociatedsmoothmuscleremovalofsuperoxideradicalsresponsetoamphetamineresponsetoantibioticresponsetoantipsychoticdrugresponsetoaxoninjuryresponsetocarbonmonoxideresponsetocopperionresponsetoethanolresponsetoheatresponsetohydrogenperoxideresponsetonutrientlevelsresponsetoorganicsubstanceresponsetosuperoxideresponsetoxenobioticstimulusretinahomeostasisretrogradeaxonaltransportsensoryperceptionofsoundspermatogenesissuperoxideaniongenerationsuperoxidemetabolicprocessthymusdevelopmenttransmissionofnerveimpulse
T-cell receptor, sp3.4 alpha chain
161
TRB protein
171
2.0
73
0.67
K7N5N2A0A0C4ZKA8K7N5N2A0A0C4ZKA8
Ribosomal oxygenase 1
300
60S ribosomal protein L8
220
2.0
74
0.66
RIOX1RL8Q9H6W3P62917chromatinorganizationhistoneH3-K36demethylationhistoneH3-K4demethylationnegativeregulationofosteoblastdifferentiationnegativeregulationoftranscriptionDNA-templatedcytoplasmictranslationtranslation
Bone marrow stromal antigen 2
58
Bone marrow stromal antigen 2
58
2.0
nan
nan
BST2BST2Q8R2Q8Q8R2Q8defenseresponsetovirusinnateimmuneresponsenegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofintracellulartransportofviralmaterialnegativeregulationofplasmacytoiddendriticcellcytokineproductionnegativeregulationofviralgenomereplicationregulationofactincytoskeletonorganizationresponsetointerferon-alpharesponsetointerferon-betaresponsetointerferon-gammaresponsetovirus
Endothelial PAS domain-containing protein 1
542
von Hippel-Lindau disease tumor suppressor
77
2.0
nan
nan
EPAS1VHLQ99814P40337angiogenesisbloodvesselremodelingcellularresponsetohypoxiaembryonicplacentadevelopmentepithelialcellmaturationerythrocytedifferentiationironionhomeostasislungdevelopmentmitochondrionorganizationmRNAtranscriptionbyRNApolymeraseIImyoblastfatecommitmentnorepinephrinemetabolicprocesspositiveregulationofcold-inducedthermogenesispositiveregulationoftranscriptionbyRNApolymeraseIIregulationofheartrateregulationofproteinneddylationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetooxidativestressresponsetohypoxiasignaltransductionsurfactanthomeostasisvisualperceptioncellmorphogenesisnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationnegativeregulationofgeneexpressionnegativeregulationofreceptorsignalingpathwayviaJAK-STATnegativeregulationoftranscriptionelongationfromRNApolymeraseIIpromoternegativeregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationofcelldifferentiationpositiveregulationoftranscriptionDNA-templatedproteinstabilizationproteinubiquitinationproteolysisregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiaregulationoftranscriptionDNA-templated
Aphrodisin
58
Aphrodisin
58
2.9
47
0.74
APHRAPHRP09465P09465
Double C2-like domain-containing protein beta
249
Double C2-like domain-containing protein beta
249
2.0
74
0.66
DOC2BDOC2BP70610P70610calciumion-regulatedexocytosisofneurotransmitterexocytosispositiveregulationofcalciumion-dependentexocytosispositiveregulationofinsulinsecretionpositiveregulationofvesiclefusionproteinlocalizationregulationofcalciumion-dependentexocytosisspontaneousneurotransmittersecretion
ETS translocation variant 4
422
ETS translocation variant 4
422
2.0
59
0.83
ETV4ETV4P43268P43268celldifferentiationpositiveregulationofkeratinocytedifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
ATP-citrate synthase
293
ATP-citrate synthase
748
2.0
58
0.85
ACLYACLYP53396P53396acetyl-CoAbiosyntheticprocesscholesterolbiosyntheticprocesscitratemetabolicprocesscoenzymeAmetabolicprocessfattyacidbiosyntheticprocesslipidbiosyntheticprocessoxaloacetatemetabolicprocess
Membrane primary amine oxidase
748
Membrane primary amine oxidase
748
2.1
40
1.18
AOC3AOC3Q16853Q16853aminemetabolicprocesscelladhesioninflammatoryresponsenegativeregulationofprimaryamineoxidaseactivityresponsetoantibiotic
Coagulation factor XII
359
Coagulation factor XII
486
2.0
62
0.79
FA12FA12P00748P00748bloodcoagulationbloodcoagulationintrinsicpathwayFactorXIIactivationfibrinolysisinnateimmuneresponseplasmakallikrein-kinincascadepositiveregulationofbloodcoagulationpositiveregulationoffibrinolysispositiveregulationofplasminogenactivationproteinautoprocessingproteinprocessingproteolysisresponsetomisfoldedproteinzymogenactivation
cAMP-dependent protein kinase type I-alpha regulatory subunit
17
cAMP-dependent protein kinase type I-alpha regulatory subunit
38
2.0
64
0.78
1
✔KAP0KAP0P00514P00514cardiacmusclecellproliferationmesodermformationnegativeregulationofactivatedTcellproliferationnegativeregulationofcAMP-dependentproteinkinaseactivitynegativeregulationofgeneexpressionsarcomereorganization
Thioredoxin-interacting protein
333
Thioredoxin-interacting protein
333
2.0
63
0.77
TXNIPTXNIPQ9H3M7Q9H3M7cellcyclecellularresponsetotumorcellkeratinocytedifferentiationnegativeregulationofcelldivisionnegativeregulationoftranscriptionbyRNApolymeraseIIplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofapoptoticprocessproteinimportintonucleusproteintransportregulationofcellpopulationproliferationresponsetocalciumionresponsetoestradiolresponsetoglucoseresponsetohydrogenperoxideresponsetomechanicalstimulusresponsetoprogesteroneresponsetoxenobioticstimulus
Lamin-B1
317
Lamin-B1
317
2.1
44
1.1
LMNB1LMNB1P20700P20700heterochromatinassemblynuclearenvelopeorganizationnuclearmigrationnuclearporelocalizationproteinlocalizationtonuclearenvelope
Collagen alpha-1(IX) chain
766
Collagen alpha-3(IX) chain
529
2.1
nan
nan
CO9A1CO9A3P20849Q14050animalorganmorphogenesisextracellularmatrixorganizationfemalegonaddevelopmentmalegonaddevelopment
Laminin subunit beta-1
1785
Laminin subunit gamma-1
1600
2.0
61
0.81
LAMB1LAMC1P07942P11047animalorganmorphogenesisbasementmembraneassemblycelladhesioncellmigrationendodermalcelldifferentiationneuronprojectiondevelopmentneuronal-glialinteractioninvolvedincerebralcortexradialgliaguidedmigrationodontogenesispositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofepithelialcellproliferationpositiveregulationofintegrin-mediatedsignalingpathwaypositiveregulationofmusclecelldifferentiationregulationofbasementmembraneorganizationsubstrateadhesion-dependentcellspreadingtissuedevelopmentendodermdevelopmentextracellularmatrixdisassemblyhemidesmosomeassemblymaintenanceofblood-brainbarrierprotein-containingcomplexassembly
Protein disulfide-isomerase A3
57
Tapasin
115
2.1
66
0.74
PDIA3TPSNP30101O15533cellularresponsetointerleukin-7extrinsicapoptoticsignalingpathwaypeptideantigenassemblywithMHCclassIproteincomplexpositiveregulationofextrinsicapoptoticsignalingpathwayproteinfoldingproteinfoldinginendoplasmicreticulumresponsetoendoplasmicreticulumstressantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIimmuneresponseMHCclassIproteincomplexassemblyMHCclassIbproteincomplexassemblypeptideantigenstabilizationprotein-containingcomplexassemblyregulationofgeneexpressionregulationofimmuneresponseregulationofproteincomplexstabilityretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulum
Thioredoxin-interacting protein
247
Thioredoxin
32
2.7
81
0.45
TXNIPTHIOQ9H3M7P10599cellcyclecellularresponsetotumorcellkeratinocytedifferentiationnegativeregulationofcelldivisionnegativeregulationoftranscriptionbyRNApolymeraseIIplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofapoptoticprocessproteinimportintonucleusproteintransportregulationofcellpopulationproliferationresponsetocalciumionresponsetoestradiolresponsetoglucoseresponsetohydrogenperoxideresponsetomechanicalstimulusresponsetoprogesteroneresponsetoxenobioticstimulusactivationofproteinkinaseBactivitycellredoxhomeostasisnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleuspositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiation
Acrosin
152
Acrosin
22
2.0
67
0.74
ACROACROP08001P08001acrosomereactionactivationofadenylatecyclaseactivityproteolysissinglefertilization
Peroxiredoxin-1
52
Peroxiredoxin-1
173
2.0
52
0.94
1
✔PRDX1PRDX1Q06830Q06830cellpopulationproliferationcellredoxhomeostasiserythrocytehomeostasisfibroblastproliferationhydrogenperoxidecatabolicprocessleukocyteactivationnaturalkillercellactivationnaturalkillercellmediatedcytotoxicityregulationofNIK/NF-kappaBsignalingregulationofstress-activatedMAPKcascaderemovalofsuperoxideradicalsretinahomeostasisskeletalsystemdevelopment
Phosphatidylinositide phosphatase SAC2
725
Phosphatidylinositide phosphatase SAC2
725
2.0
57
0.87
SAC2SAC2Q9Y2H2Q9Y2H2adultlocomotorybehaviorcardiacmusclehypertrophyinresponsetostressclathrin-dependentendocytosisnegativeregulationofaxonregenerationnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationoftyrosinephosphorylationofSTATproteinphosphatidylinositolbiosyntheticprocessphosphatidylinositolcatabolicprocessphosphatidylinositoldephosphorylationphosphatidylinositol-mediatedsignalingpositiveregulationofreceptorrecyclingregulationofcellmotilityregulationofendocyticrecyclingregulationofproteinkinaseBsignaling
Rootletin
1152
Rootletin
1152
2.0
nan
nan
CROCCCROCCQ5TZA2Q5TZA2cellularhomeostasiscentriole-centriolecohesioncentrosomecycleciliarybasalbodyorganizationepithelialstructuremaintenanceestablishmentoflocalizationincellestablishmentoforganellelocalizationphotoreceptorcellmaintenancepositiveregulationofciliumassemblypositiveregulationofproteinlocalizationtociliumproteinlocalizationproteinlocalizationtoorganelle
Angiotensinogen
340
Angiotensinogen
340
2.0
69
0.71
ANGTANGTP11859P11859activationofNF-kappaB-inducingkinaseactivityactivationofphospholipaseCactivityaldosteronesecretionangiotensin-activatedsignalingpathwayangiotensin-mediateddrinkingbehaviorangiotensin-mediatedvasoconstrictioninvolvedinregulationofsystemicarterialbloodpressurearterysmoothmusclecontractionassociativelearningastrocyteactivationbloodvesseldevelopmentbrainrenin-angiotensinsystembranchinginvolvedinuretericbudmorphogenesiscellgrowthinvolvedincardiacmusclecelldevelopmentcellpopulationproliferationcellsurfacereceptorsignalingpathwaycell-matrixadhesioncellularsodiumionhomeostasisdrinkingbehaviorERK1andERK2cascadeestablishmentofblood-nervebarrierextracellularmatrixorganizationfibroblastproliferationGprotein-coupledreceptorsignalingpathwayhormonemetabolicprocesskidneydevelopmentMAPKcascadenegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofendopeptidaseactivitynegativeregulationofgeneexpressionnegativeregulationofMAPkinaseactivitynegativeregulationofneuronapoptoticprocessnegativeregulationofneurotrophinTRKreceptorsignalingpathwaynegativeregulationofsmoothmusclecellproliferationnegativeregulationoftissueremodelingnegativeregulationofvascularassociatedsmoothmusclecellproliferationneuronapoptoticprocessoperantconditioningorgangrowthovarianfollicleruptureperistalsispositiveregulationofactivationofJanuskinaseactivitypositiveregulationofbloodpressurepositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcardiacmusclehypertrophypositiveregulationofcatalyticactivitypositiveregulationofcellpopulationproliferationpositiveregulationofCoA-transferaseactivitypositiveregulationofcytokineproductionpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofendothelialcellmigrationpositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofextracellularmatrixconstituentsecretionpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationoffattyacidbiosyntheticprocesspositiveregulationoffibroblastproliferationpositiveregulationofgapjunctionassemblypositiveregulationofgeneexpressionpositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofL-arginineimportacrossplasmamembranepositiveregulationofL-lysineimportacrossplasmamembranepositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofMAPKcascadepositiveregulationofmembranehyperpolarizationpositiveregulationofmulticellularorganismgrowthpositiveregulationofneuronprojectiondevelopmentpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationoforgangrowthpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseCactivitypositiveregulationofproteinmetabolicprocesspositiveregulationofproteintyrosinekinaseactivitypositiveregulationofrenalsodiumexcretionpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularassociatedsmoothmusclecellmigrationpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinimportintonucleusregulationofapoptoticprocessregulationofbloodpressureregulationofcalciumiontransportregulationofcardiacconductionregulationofextracellularmatrixassemblyregulationofgeneexpressionregulationofheartrateregulationofinflammatoryresponseregulationoflong-termneuronalsynapticplasticityregulationofnorepinephrinesecretionregulationofrenaloutputbyangiotensinregulationofrenalsodiumexcretionregulationofsystemicarterialbloodpressurebycirculatoryrenin-angiotensinregulationoftransmissionofnerveimpulserenalresponsetobloodflowinvolvedincirculatoryrenin-angiotensinregulationofsystemicarterialbloodpressurerenalsystemprocessrenin-angiotensinregulationofaldosteroneproductionresponsetocoldresponsetomuscleactivityinvolvedinregulationofmuscleadaptationresponsetosaltstresssmoothmusclecelldifferentiationsmoothmusclecellproliferationstress-activatedMAPKcascadeuterinesmoothmusclecontractionvascularassociatedsmoothmusclecellproliferationvasoconstrictionvasodilationvasopressinsecretion
EKC/KEOPS complex subunit TPRKB
167
EKC/KEOPS complex subunit TPRKB
167
2.0
63
0.78
TPRKBTPRKBQ9Y3C4Q9Y3C4telomeremaintenanceviarecombinationtRNAthreonylcarbamoyladenosinemodification
IGK@ protein
235
Immunoglobulin heavy constant mu
14
2.0
nan
nan
Q6PJF2IGHMQ6PJF2P01871adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Ubiquitin-conjugating enzyme E2 S
118
Ubiquitin-conjugating enzyme E2 S
118
1.8
77
0.71
UBE2SUBE2SQ16763Q16763anaphase-promotingcomplex-dependentcatabolicprocesscelldivisionexitfrommitosisfreeubiquitinchainpolymerizationpositiveregulationofubiquitinproteinligaseactivityproteinK11-linkedubiquitinationproteinK27-linkedubiquitinationproteinK29-linkedubiquitinationproteinK6-linkedubiquitinationproteinK63-linkedubiquitinationproteinmodificationprocessproteinpolyubiquitinationubiquitin-dependentproteincatabolicprocess
Transforming growth factor beta-1 proprotein
33
Transforming growth factor beta activator LRRC32
211
2.0
85
0.58
TGFB1LRC32P01137Q14392aorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaycellmigrationcell-celljunctionorganizationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluschondrocytedifferentiationcommon-partnerSMADproteinphosphorylationconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingembryonicliverdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayheartdevelopmentheartvalvemorphogenesishematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphnodedevelopmentmacrophagederivedfoamcelldifferentiationMAPKcascademembraneproteinintracellulardomainproteolysisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofcytolysisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixdisassemblynegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofmacrophagecytokineproductionnegativeregulationofmiRNAmaturationnegativeregulationofmiRNAtranscriptionnegativeregulationofmiRNA-mediatedgenesilencingnegativeregulationofmyoblastdifferentiationnegativeregulationofproteinlocalizationtoplasmamembranenegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationoftranscriptionDNA-templatedneuraltubeclosureneuraltubedevelopmentossificationinvolvedinboneremodelingpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixassemblypositiveregulationoffibroblastmigrationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationofSMADproteinsignaltransductionpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularpermeabilityproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofbindingregulationofbloodvesselremodelingregulationofcellmigrationregulationofcellpopulationproliferationregulationofDNAbindingregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesisnegativeregulationofactivatedTcellproliferationnegativeregulationofcytokineproductionregulationoftransforminggrowthfactorbetaactivationregulationoftransforminggrowthfactorbeta3activationsecondarypalatedevelopment
Glial cell line-derived neurotrophic factor
178
Glial cell line-derived neurotrophic factor
178
2.0
71
0.71
GDNFGDNFQ07731Q07731branchinginvolvedinuretericbudmorphogenesiscellpopulationproliferationcellularresponsetodexamethasonestimuluscommissuralneuronaxonguidancedorsalspinalcorddevelopmentembryonicorgandevelopmententericnervoussystemdevelopmentmalegonaddevelopmentmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesismetanephrosdevelopmentmidbraindevelopmentmRNAstabilizationnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofneuronapoptoticprocessnervoussystemdevelopmentneuralcrestcellmigrationneurondifferentiationneuronprojectiondevelopmentorganinductionperipheralnervoussystemdevelopmentperistalsispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesispositiveregulationofmonooxygenaseactivitypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofuretericbudformationpostganglionicparasympatheticfiberdevelopmentpostsynapticmembraneorganizationregulationofdopamineuptakeinvolvedinsynaptictransmissionregulationofgeneexpressionregulationofmorphogenesisofabranchingstructureregulationofsemaphorin-plexinsignalingpathwayregulationofuretericbudformationresponsetowoundingretinadevelopmentincamera-typeeyesympatheticnervoussystemdevelopmenturetericbuddevelopmenturetericbudformation
Fibrinogen gamma chain
35
Fibrinogen gamma chain
34
2.0
53
0.93
FIBGFIBGP02679P02679bloodcoagulationfibrinclotformationcell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetointerleukin-6fibrinolysisnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofplateletaggregationplasminogenactivationplateletaggregationplateletmaturationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationproteinsecretionprotein-containingcomplexassemblyresponsetocalciumion
Homeobox protein NANOG
109
Homeobox protein NANOG
151
2.0
53
0.93
NANOGNANOGQ80Z64Q80Z64BMPsignalingpathwaycelldedifferentiationcellularresponsetoerythropoietincellularresponsetorapamycinembryonicpatternspecificationendodermalcellfatespecificationgeneexpressiongonaddevelopmentmesodermalcellfatecommitmentmultidimensionalcellgrowthnegativeregulationofBMPsignalingpathwaynegativeregulationofcellfatecommitmentnegativeregulationofendodermalcellfatespecificationnegativeregulationofstemcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellpopulationproliferationpositiveregulationofmitoticcellcyclepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofstemcelldivisionregulationoftranscriptionbyRNApolymeraseIIresponsetoorganicsubstanceresponsetoretinoicacidsomaticstemcellpopulationmaintenancestemcelldifferentiationstemcelldivisionstemcellpopulationmaintenancetissueregeneration
DNA helicase MCM8
351
DNA helicase MCM8
351
2.0
54
0.91
MCM8MCM8Q9UJA3Q9UJA3cellcyclecellularresponsetoDNAdamagestimulusDNAduplexunwindingdouble-strandbreakrepairviahomologousrecombinationfemalegametegenerationmalegametegenerationmismatchrepairinvolvedinmaintenanceoffidelityinvolvedinDNA-dependentDNAreplicationproteinlocalizationtochromatinproteinstabilizationrecombinationalinterstrandcross-linkrepair
Interferon lambda-3
69
Interferon lambda-3
69
2.0
60
0.82
IFNL3IFNL3Q8IZI9Q8IZI9cellularresponsetovirusdefenseresponsetovirusinnateimmuneresponsenegativeregulationofviralgenomereplicationpositiveregulationofimmuneresponsereceptorsignalingpathwayviaJAK-STATtypeIIIinterferonsignalingpathway
Thioredoxin
73
Thioredoxin
73
2.0
74
0.67
THIOTHIOP10599P10599activationofproteinkinaseBactivitycellredoxhomeostasisnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiation
Actin, cytoplasmic 1
374
Actin, cytoplasmic 1
374
2.0
nan
nan
ACTBACTBP60712P60712adherensjunctionassemblyapicalproteinlocalizationaxonogenesiscellmotilitycellularresponsetocytochalasinBestablishmentormaintenanceofcellpolarityhistoneH2AacetylationhistoneH4acetylationmorphogenesisofapolarizedepitheliumnegativeregulationofproteinbindingpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationproteinlocalizationtoadherensjunctionregulationofcellcycleregulationofnorepinephrineuptakeregulationofproteinlocalizationtoplasmamembraneregulationoftransepithelialtransportregulationoftransmembranetransporteractivitysynapticvesicleendocytosis
Serine/threonine-protein kinase Nek1
163
Serine/threonine-protein kinase Nek1
276
2.1
76
0.63
NEK1NEK1Q96PY6Q96PY6cellcyclecelldivisionciliumassemblyproteinphosphorylation
Acid ceramidase
31
Acid ceramidase
340
2.0
63
0.78
ASAH1ASAH1Q13510Q13510cellularresponsetotumornecrosisfactorceramidebiosyntheticprocessceramidecatabolicprocessfattyacidmetabolicprocesskeratinocytedifferentiationnegativeregulationofnucleicacid-templatedtranscriptionregulationofprogrammednecroticcelldeathregulationofsteroidbiosyntheticprocesssphingosinebiosyntheticprocess
Lysosomal alpha-mannosidase
56
Lysosomal alpha-mannosidase
360
2.0
66
0.74
MA2B1MA2B1Q29451Q29451mannosemetabolicprocessproteinmodificationprocess
Protein AF-9
5
Protein AF-9
5
2.0
64
0.78
AF9AF9P42568P42568anterior/posteriorpatternspecificationchromatinremodelinggeneexpressionhematopoieticstemcelldifferentiationhistoneacetylationnegativeregulationofcanonicalWntsignalingpathwaypositiveregulationoftranscriptionDNA-templatedpositiveregulationofWntsignalingpathwayplanarcellpolaritypathwayregulationofchromatinorganizationregulationofstemcelldivisionregulationoftranscriptionbyRNApolymeraseIIsegmentspecification
Insulin
84
Insulin
31
2.0
58
0.84
A6XGL2A6XGL2A6XGL2A6XGL2glucosemetabolicprocess
cAMP-dependent protein kinase type I-beta regulatory subunit
18
cAMP-dependent protein kinase type I-beta regulatory subunit
39
2.0
44
1.12
KAP1KAP1P31321P31321learningormemorynegativeregulationofcAMP-dependentproteinkinaseactivitypositiveregulationofexcitatorypostsynapticpotentialpositiveregulationoffearresponsepositiveregulationoflong-termsynapticpotentiationpositiveregulationofsensoryperceptionofpainproteinphosphorylationregulationofsynapticvesiclecycle
Tumor suppressor candidate 3
99
Interleukin-1 receptor accessory protein-like 1
216
2.0
52
0.94
TUSC3IRPL1Q13454Q9NZN1cognitionmagnesiumiontransportproteinN-linkedglycosylationproteinN-linkedglycosylationviaasparaginetransmembranetransportheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesnegativeregulationofexocytosisneurondifferentiationpositiveregulationofdendritemorphogenesispositiveregulationofsynapseassemblypresynapticmembraneassemblyregulationofneuronprojectiondevelopmentregulationofpostsynapseorganizationregulationofpresynapseassemblysignaltransductiontrans-synapticsignalingbytrans-synapticcomplex
B-cell antigen receptor complex-associated protein beta chain
135
B-cell antigen receptor complex-associated protein beta chain
135
2.0
64
0.76
CD79BCD79BP15530P15530adaptiveimmuneresponseBcelldifferentiationBcellreceptorsignalingpathwayresponsetobacterium
Kinetochore-associated protein DSN1 homolog
191
Kinetochore-associated protein NSL1 homolog
40
2.0
65
0.76
DSN1NSL1Q9H410Q96IY1celldivisionmitoticsisterchromatidsegregation
Interleukin-1 receptor-associated kinase 3
202
Interleukin-1 receptor-associated kinase 3
287
2.0
49
1.01
IRAK3IRAK3Q9Y616Q9Y616cytokine-mediatedsignalingpathwayinterleukin-1-mediatedsignalingpathwayintracellularsignaltransductionMyD88-dependenttoll-likereceptorsignalingpathwaynegativeregulationofcytokine-mediatedsignalingpathwaynegativeregulationofinnateimmuneresponsenegativeregulationofinterleukin-12productionnegativeregulationofinterleukin-6productionnegativeregulationofmacrophagecytokineproductionnegativeregulationofMAPkinaseactivitynegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofproteincatabolicprocessnegativeregulationofprotein-containingcomplexdisassemblynegativeregulationoftoll-likereceptorsignalingpathwaynegativeregulationoftumornecrosisfactorproductionpositiveregulationofcytokineproductionpositiveregulationofmacrophagetoleranceinductionpositiveregulationofNF-kappaBtranscriptionfactoractivityproteinautophosphorylationproteinphosphorylationregulationofprotein-containingcomplexdisassemblyresponsetoexogenousdsRNAresponsetointerleukin-1responsetolipopolysaccharideresponsetopeptidoglycanresponsetovirus
Proteasome activator complex subunit 1
22
Proteasome activator complex subunit 2
5
2.0
nan
nan
PSME1PSME2P97371P97372antigenprocessingandpresentationofexogenousantigenpositiveregulationofendopeptidaseactivityregulationofG1/Stransitionofmitoticcellcycleregulationofproteasomalproteincatabolicprocess
Pancreatic trypsin inhibitor
40
Pancreatic trypsin inhibitor
90
2.0
60
0.82
BPT1BPT1P00974P00974negativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Peroxiredoxin-1
173
Peroxiredoxin-1
52
2.0
52
0.94
1
✔PRDX1PRDX1Q63716Q63716cellpopulationproliferationcellredoxhomeostasiserythrocytehomeostasishydrogenperoxidecatabolicprocessleukocyteactivationnaturalkillercellactivationnaturalkillercellmediatedcytotoxicityregulationofNIK/NF-kappaBsignalingregulationofstress-activatedMAPKcascaderemovalofsuperoxideradicalsresponsetooxidativestressresponsetoreactiveoxygenspecies
Acyloxyacyl hydrolase
122
Acyloxyacyl hydrolase
453
2.0
59
0.83
AOAHAOAHO18823O18823fattyacidmetabolicprocesslipopolysaccharidecatabolicprocess
Heat shock factor 2-binding protein
120
Heat shock factor 2-binding protein
120
2.0
62
0.79
HSF2BHSF2BO75031O75031double-strandbreakrepairinvolvedinmeioticrecombinationfemalemeiosisImalemeiosisIspermatogenesistranscriptionbyRNApolymeraseII
Caspase recruitment domain-containing protein 11
28
Caspase recruitment domain-containing protein 11
28
2.0
56
0.87
CAR11CAR11Q9BXL7Q9BXL7BcelldifferentiationBcellproliferationCD4-positivealpha-betaTcellproliferationhomeostasisofnumberofcellsI-kappaBkinase/NF-kappaBsignalingpositiveregulationofBcellproliferationpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-2productionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofTcellreceptorsignalingpathwayproteinhomooligomerizationregulationofapoptoticprocessregulationofBcelldifferentiationregulationofTcelldifferentiationTcellcostimulationthymicTcellselectionTORC1signaling
Ceramidase
31
Ceramidase
340
2.0
63
0.78
A8K0B6A8K0B6A8K0B6A8K0B6fattyacidmetabolicprocess
Ryanodine receptor 3
852
Ryanodine receptor 3
852
2.0
62
0.79
RYR3RYR3Q15413Q15413calciumiontransmembranetransportcalciumiontransportcellularcalciumionhomeostasiscellularresponsetoATPcellularresponsetocaffeinecellularresponsetocalciumioncellularresponsetomagnesiumionproteinhomotetramerization
Potassium channel subfamily K member 10
118
Potassium channel subfamily K member 10
118
2.0
42
1.17
KCNKAKCNKAP57789P57789memorypotassiumiontransmembranetransportregulationofiontransmembranetransportsignaltransductionstabilizationofmembranepotential
Fragile X messenger ribonucleoprotein 1
99
Fragile X messenger ribonucleoprotein 1
99
2.0
49
1.0
FMR1FMR1Q06787Q06787cellularresponsetovirusDNArepairgenesilencingbyRNAglutamatereceptorsignalingpathwaymodulationbyhostofviralRNAgenomereplicationmRNAprocessingmRNAtransportnegativeregulationofcytoplasmictranslationnegativeregulationoflong-termsynapticdepressionnegativeregulationofmRNAcatabolicprocessnegativeregulationofsynapticvesicleexocytosisnegativeregulationoftranslationnegativeregulationoftranslationalinitiationnegativeregulationofvoltage-gatedcalciumchannelactivitynervoussystemdevelopmentpositiveregulationofdendriticspinedevelopmentpositiveregulationoffilopodiumassemblypositiveregulationofintracellulartransportofviralmaterialpositiveregulationofmiRNA-mediatedgenesilencingpositiveregulationofmRNAbindingpositiveregulationofproteasomalproteincatabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofreceptorinternalizationpositiveregulationofresponsetoDNAdamagestimuluspositiveregulationoftranslationregulationofalternativemRNAsplicingviaspliceosomeregulationofdendriticspinedevelopmentregulationoffilopodiumassemblyregulationofmiRNA-mediatedgenesilencingregulationofmRNAstabilityregulationofneuronalactionpotentialregulationofneurotransmittersecretionRNAsplicing
Apoptotic chromatin condensation inducer in the nucleus
1083
Apoptotic chromatin condensation inducer in the nucleus
1083
2.0
78
0.63
ACINUACINUQ9UKV3Q9UKV3apoptoticchromosomecondensationerythrocytedifferentiationmRNAprocessingnegativeregulationofmRNAsplicingviaspliceosomepositiveregulationofapoptoticprocesspositiveregulationofmonocytedifferentiationRNAsplicing
Protein diaphanous homolog 1
428
Protein diaphanous homolog 1
428
2.0
75
0.65
DIAP1DIAP1O08808O08808actincytoskeletonorganizationactinfilamentpolymerizationbraindevelopmentcellularresponsetohistaminecytoskeletonorganizationneuronprojectiondevelopmentpositiveregulationofcellmigrationproteinlocalizationtomicrotubuleregulationofcellshaperegulationofcytoskeletonorganizationregulationofmicrotubule-basedprocessregulationofreleaseofsequesteredcalciumionintocytosolsensoryperceptionofsound
Poly [ADP-ribose] polymerase 1
845
Protein timeless homolog
1038
2.0
61
0.8
PARP1TIMP09874Q9UNS1apoptoticprocessATPgenerationfrompoly-ADP-D-ribosecellularresponsetoamyloid-betacellularresponsetoDNAdamagestimuluscellularresponsetoinsulinstimuluscellularresponsetooxidativestresscellularresponsetoUVcellularresponsetozincionDNAADP-ribosylationDNArepairdouble-strandbreakrepairmacrophagedifferentiationmitochondrialDNAmetabolicprocessmitochondrialDNArepairmitochondrionorganizationnegativeregulationofATPbiosyntheticprocessnegativeregulationoftelomeremaintenanceviatelomerelengtheningnegativeregulationoftranscriptionbyRNApolymeraseIIpeptidyl-glutamicacidpoly-ADP-ribosylationpeptidyl-serineADP-ribosylationpositiveregulationofcardiacmusclehypertrophypositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofmitochondrialdepolarizationpositiveregulationofmyofibroblastdifferentiationpositiveregulationofneurondeathpositiveregulationofproteinlocalizationtonucleuspositiveregulationofsinglestrandbreakrepairpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingproteinADP-ribosylationproteinauto-ADP-ribosylationproteinautoprocessingproteinmodificationprocessproteinpoly-ADP-ribosylationregulationofcatalyticactivityregulationofDNAmethylationregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwayregulationofproteinlocalizationregulationofSMADproteincomplexassemblyresponsetoaldosteroneresponsetogammaradiationsignaltransductioninvolvedinregulationofgeneexpressiontelomeremaintenancetranscriptionbyRNApolymeraseIItransforminggrowthfactorbetareceptorsignalingpathwaybranchingmorphogenesisofanepithelialtubecellcyclephasetransitioncelldivisioncellularresponsetobleomycincellularresponsetocisplatincellularresponsetohydroxyureacircadianrhythmdetectionofabioticstimulusDNAreplicationcheckpointsignalinglungdevelopmentmorphogenesisofanepitheliumnegativeregulationoftranscriptionDNA-templatedpositiveregulationofdouble-strandbreakrepairregulationofcircadianrhythmreplicationforkarrestreplicationforkprotection
Ubiquitin carboxyl-terminal hydrolase 11
204
Ubiquitin carboxyl-terminal hydrolase 11
204
2.0
46
1.07
UBP11UBP11Q5D006Q5D006proteindeubiquitinationubiquitin-dependentproteincatabolicprocess
Ceramide-1-phosphate transfer protein
163
Ceramide-1-phosphate transfer protein
163
2.0
58
0.85
CPTPCPTPQ5TA50Q5TA50ceramide1-phosphatetransportceramidetransportglycosphingolipidmetabolicprocessintermembranelipidtransfernegativeregulationofautophagynegativeregulationofinterleukin-1betaproductionnegativeregulationofNLRP3inflammasomecomplexassembly
Protein FosB
172
Protein FosB
172
2.0
50
0.98
FOSBFOSBP53539P53539cellularresponsetocalciumioncellularresponsetohormonestimulusfemalepregnancynegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIresponsetocAMPresponsetocorticosteroneresponsetomechanicalstimulusresponsetomorphineresponsetoprogesteroneresponsetoxenobioticstimulustranscriptionbyRNApolymeraseII
B-cell antigen receptor complex-associated protein beta chain
136
B-cell antigen receptor complex-associated protein beta chain
136
2.0
75
0.65
CD79BCD79BP40259P40259adaptiveimmuneresponseBcelldifferentiationBcellreceptorsignalingpathwayimmuneresponsesignaltransduction
Induced myeloid leukemia cell differentiation protein Mcl-1
286
Induced myeloid leukemia cell differentiation protein Mcl-1
286
2.0
62
0.79
MCL1MCL1Q07820Q07820cellfatedeterminationcellularhomeostasisextrinsicapoptoticsignalingpathwayinabsenceofligandintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofanoikisnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofapoptoticprocesspositiveregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwayregulationofapoptoticprocessregulationofresponsetoDNAdamagestimulusresponsetocytokine
Adenylyl cyclase-associated protein 1
92
Adenylyl cyclase-associated protein 1
92
2.0
63
0.78
CAP1CAP1P40124P40124actincytoskeletonorganizationameboidal-typecellmigrationcAMP-mediatedsignalingcellmorphogenesisreceptor-mediatedendocytosisregulationofadenylatecyclaseactivity
Cryptochrome-2
430
F-box/LRR-repeat protein 3
340
2.0
89
0.55
CRY2FBXL3Q9R194Q9UKT7circadianregulationofgeneexpressioncircadianrhythmentrainmentofcircadianclockbyphotoperiodglucosehomeostasislipidstoragenegativeregulationofcircadianrhythmnegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofglucocorticoidsecretionnegativeregulationofphosphoproteinphosphataseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedproteinimportintonucleusregulationofcircadianrhythmregulationofsodium-dependentphosphatetransportresponsetoactivityresponsetoinsulinresponsetolightstimulusG2/MtransitionofmitoticcellcycleproteindestabilizationproteinubiquitinationregulationofcellcyclerhythmicprocessSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocess
Ig gamma-2A chain C region, A allele
112
Ig gamma-2A chain C region, A allele
112
2.0
35
1.4
GCAAGCAAP01863P01863BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationresponsetobacterium
Potassium channel subfamily K member 2
108
Potassium channel subfamily K member 2
108
2.0
41
1.2
KCNK2KCNK2O95069O95069cardiacventricledevelopmentcellularresponsetohypoxiacochleadevelopmentGprotein-coupledreceptorsignalingpathwaymemorynegativeregulationofcardiacmusclecellproliferationnegativeregulationofDNAbiosyntheticprocesspositiveregulationofcelldeathpositiveregulationofcellularresponsetohypoxiapotassiumiontransmembranetransportresponsetoaxoninjuryresponsetomechanicalstimulusstabilizationofmembranepotential
Meprin A subunit beta
305
Meprin A subunit beta
305
2.0
48
1.02
MEP1BMEP1BQ16820Q16820inflammatoryresponseproteolysistoxintransport
Huntingtin-interacting protein 1
430
Huntingtin-interacting protein 1
430
2.0
57
0.86
HIP1HIP1O00291O00291actinfilamentorganizationactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocessapoptoticsignalingpathwaycelldifferentiationclathrincoatassemblyclathrin-dependentendocytosisendocytosisneurotransmitterreceptortransportpositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofproteinkinaseBsignalingpositiveregulationofreceptor-mediatedendocytosisproteinstabilizationregulationofapoptoticprocessregulationofendocytosis
Transducin-like enhancer protein 1
89
Transducin-like enhancer protein 1
89
2.0
75
0.65
TLE1TLE1Q04724Q04724animalorganmorphogenesisnegativeregulationofanoikisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationoftranscriptionDNA-templatednegativeregulationofWntsignalingpathwaypositiveregulationofgeneexpressionsignaltransductionWntsignalingpathway
Collagen alpha-1(I) chain
1265
Collagen alpha-1(I) chain
1282
2.1
58
0.83
CO1A1CO1A1P02452P02452bloodvesseldevelopmentbonetrabeculaformationcartilagedevelopmentinvolvedinendochondralbonemorphogenesiscellularresponsetoaminoacidstimuluscellularresponsetoepidermalgrowthfactorstimuluscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetofluoridecellularresponsetomechanicalstimuluscellularresponsetoretinoicacidcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetotumornecrosisfactorcellularresponsetovitaminEcollagenbiosyntheticprocesscollagenfibrilorganizationcollagen-activatedtyrosinekinasereceptorsignalingpathwayembryonicskeletalsystemdevelopmentendochondralossificationextracellularmatrixorganizationfacemorphogenesisintramembranousossificationnegativeregulationofcell-substrateadhesionossificationosteoblastdifferentiationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationoftranscriptionDNA-templatedproteinlocalizationtonucleusproteintransportresponsetocAMPresponsetocorticosteroidresponsetoestradiolresponsetohydrogenperoxideresponsetohyperoxiaresponsetomechanicalstimulusresponsetopeptidehormoneresponsetoxenobioticstimulussensoryperceptionofsoundskeletalsystemdevelopmentskindevelopmentskinmorphogenesistootheruptiontoothmineralizationvisualperceptionwoundhealing
RNA-binding protein 12
887
RNA-binding protein 12
887
2.1
83
0.58
RBM12RBM12Q9NTZ6Q9NTZ6regulationofRNAsplicing
Peroxiredoxin-1
52
Sulfiredoxin-1
99
2.1
72
0.67
PRDX1SRXN1Q06830Q9BYN0cellpopulationproliferationcellredoxhomeostasiserythrocytehomeostasisfibroblastproliferationhydrogenperoxidecatabolicprocessleukocyteactivationnaturalkillercellactivationnaturalkillercellmediatedcytotoxicityregulationofNIK/NF-kappaBsignalingregulationofstress-activatedMAPKcascaderemovalofsuperoxideradicalsretinahomeostasisskeletalsystemdevelopmentcellularresponsetooxidativestressresponsetooxidativestress
Thioredoxin reductase 1, cytoplasmic
608
Thioredoxin reductase 1, cytoplasmic
608
2.1
66
0.73
TRXR1TRXR1Q16881Q16881cellpopulationproliferationcellredoxhomeostasismesodermformationsignaltransduction
Caspase-2
436
Caspase-2
436
2.1
83
0.58
CASP2CASP2P42575P42575activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessagingapoptoticprocessapoptoticsignalingpathwaybraindevelopmentcellularresponsetoDNAdamagestimuluscellularresponsetomechanicalstimulusDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestectopicgermcellprogrammedcelldeathexecutionphaseofapoptosisextrinsicapoptoticsignalingpathwayinabsenceofligandintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageluteolysisnegativeregulationofapoptoticprocessnegativeregulationofnecroptoticprocessneuralretinadevelopmentpositiveregulationofapoptoticprocesspositiveregulationofapoptoticsignalingpathwaypositiveregulationofneuronapoptoticprocessproteinprocessingreleaseofcytochromecfrommitochondria
Potassium channel subfamily K member 4
52
Potassium channel subfamily K member 4
52
2.1
62
0.78
KCNK4KCNK4O88454O88454cellularresponsetoalkalinepHcellularresponsetofattyacidcellularresponsetomechanicalstimuluscellularresponsetotemperaturestimulusdetectionofmechanicalstimulusinvolvedinsensoryperceptionoftouchmemorypotassiumiontransmembranetransportregulationofiontransmembranetransportsensoryperceptionofpainsensoryperceptionoftemperaturestimulusstabilizationofmembranepotential
Thioredoxin-interacting protein
63
Thioredoxin-interacting protein
63
2.1
68
0.71
TXNIPTXNIPQ9H3M7Q9H3M7cellcyclecellularresponsetotumorcellkeratinocytedifferentiationnegativeregulationofcelldivisionnegativeregulationoftranscriptionbyRNApolymeraseIIplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofapoptoticprocessproteinimportintonucleusproteintransportregulationofcellpopulationproliferationresponsetocalciumionresponsetoestradiolresponsetoglucoseresponsetohydrogenperoxideresponsetomechanicalstimulusresponsetoprogesteroneresponsetoxenobioticstimulus
Complement component C8 alpha chain
194
Complement component C8 gamma chain
60
2.1
64
0.75
CO8ACO8GP07357P07360complementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisimmuneresponsepositiveregulationofimmuneresponse
Complement C1r subcomponent
451
Complement C1r subcomponent
577
2.1
72
0.67
C1RC1RP00736P00736complementactivationclassicalpathwayimmuneresponseinnateimmuneresponsezymogenactivation
Potassium channel subfamily K member 1
69
Potassium channel subfamily K member 1
69
2.1
44
1.09
KCNK1KCNK1O00180O00180potassiumiontransmembranetransportpotassiumiontransportregulationofrestingmembranepotentialresponsetonicotinesodiumiontransmembranetransportstabilizationofmembranepotential
Fibrinogen beta chain
223
Fibrinogen gamma chain
161
2.1
71
0.68
FIBBFIBGP02675P02679adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Integrator complex subunit 11
542
Integrator complex subunit 11
542
2.1
57
0.85
INT11INT11Q5TA45Q5TA45regulationoftranscriptionelongationfromRNApolymeraseIIpromotersnRNAprocessing
Sodium channel subunit beta-4
58
Sodium channel subunit beta-4
58
2.1
38
1.27
SCN4BSCN4BQ8IWT1Q8IWT1AVnodecellactionpotentialcardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractionestablishmentoflocalizationincellmembranedepolarizationduringcardiacmusclecellactionpotentialpositiveregulationofsodiumiontransportregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityregulationofventricularcardiacmusclecellmembranerepolarizationsodiumiontransmembranetransportsodiumiontransport
Neutrophil gelatinase-associated lipocalin
107
Neutrophil gelatinase-associated lipocalin
107
2.1
40
1.21
NGALNGALP80188P80188apoptoticprocessdefenseresponsetobacteriuminnateimmuneresponsepositiveregulationofcold-inducedthermogenesissequesteringofironionsiderophoretransport
Placenta growth factor
86
Placenta growth factor
77
2.1
69
0.7
PLGFPLGFP49763P49763animalorganregenerationcelldifferentiationcell-cellsignalingcellularresponsetohormonestimulusfemalepregnancyinductionofpositivechemotaxispositiveregulationofangiogenesispositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellproliferationpositiveregulationofmastcellchemotaxispositiveregulationofproteinphosphorylationresponsetohypoxiaresponsetoxenobioticstimulussignaltransductionsproutingangiogenesisvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathway
Bone morphogenetic protein 3
436
Bone morphogenetic protein 3
436
2.1
91
0.53
BMP3BMP3P12645P12645cartilagedevelopmentcell-cellsignalingosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationskeletalsystemdevelopmentSMADproteinsignaltransduction
Poly [ADP-ribose] polymerase 1
845
Poly [ADP-ribose] polymerase 1
845
2.1
65
0.74
PARP1PARP1P09874P09874apoptoticprocessATPgenerationfrompoly-ADP-D-ribosecellularresponsetoamyloid-betacellularresponsetoDNAdamagestimuluscellularresponsetoinsulinstimuluscellularresponsetooxidativestresscellularresponsetoUVcellularresponsetozincionDNAADP-ribosylationDNArepairdouble-strandbreakrepairmacrophagedifferentiationmitochondrialDNAmetabolicprocessmitochondrialDNArepairmitochondrionorganizationnegativeregulationofATPbiosyntheticprocessnegativeregulationoftelomeremaintenanceviatelomerelengtheningnegativeregulationoftranscriptionbyRNApolymeraseIIpeptidyl-glutamicacidpoly-ADP-ribosylationpeptidyl-serineADP-ribosylationpositiveregulationofcardiacmusclehypertrophypositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofmitochondrialdepolarizationpositiveregulationofmyofibroblastdifferentiationpositiveregulationofneurondeathpositiveregulationofproteinlocalizationtonucleuspositiveregulationofsinglestrandbreakrepairpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingproteinADP-ribosylationproteinauto-ADP-ribosylationproteinautoprocessingproteinmodificationprocessproteinpoly-ADP-ribosylationregulationofcatalyticactivityregulationofDNAmethylationregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwayregulationofproteinlocalizationregulationofSMADproteincomplexassemblyresponsetoaldosteroneresponsetogammaradiationsignaltransductioninvolvedinregulationofgeneexpressiontelomeremaintenancetranscriptionbyRNApolymeraseIItransforminggrowthfactorbetareceptorsignalingpathway
SUN domain-containing protein 1
630
Nesprin-1
8774
2.1
50
0.96
SUN1SYNE1O94901Q8NF91centrosomelocalizationhomologouschromosomepairingatmeiosismeioticattachmentoftelomeretonuclearenvelopenuclearenvelopeorganizationnuclearmatrixanchoringatnuclearmembranenucleokinesisinvolvedincellmotilityincerebralcortexradialgliaguidedmigrationspermatogenesisGolgiorganizationmusclecelldifferentiationnucleusorganization
Nitric oxide synthase, inducible
115
Nitric oxide synthase, inducible
115
2.1
78
0.62
NOS2NOS2P35228P35228argininecatabolicprocesscellredoxhomeostasiscellularresponsetointerferon-gammacellularresponsetolipopolysaccharidecellularresponsetoxenobioticstimuluscircadianrhythmdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriuminflammatoryresponseinnateimmuneresponseinmucosanegativeregulationofbloodpressurenegativeregulationofgeneexpressionnegativeregulationofproteincatabolicprocessnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionpeptidyl-cysteineS-nitrosylationpositiveregulationofguanylatecyclaseactivitypositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofkillingofcellsofanotherorganismpositiveregulationofleukocytemediatedcytotoxicityprostaglandinsecretionregulationofcellpopulationproliferationregulationofcellularrespirationregulationofcytokineproductioninvolvedininflammatoryresponseregulationofinsulinsecretionresponsetobacteriumresponsetohormoneresponsetohypoxiaresponsetolipopolysaccharidesuperoxidemetabolicprocess
Lysosomal protective protein
88
Lysosomal protective protein
362
2.0
78
0.63
PPGBPPGBP10619P10619intracellularproteintransportnegativeregulationofchaperone-mediatedautophagyproteolysisregulationofchaperone-mediatedautophagyregulationofproteinstability
G-protein-signaling modulator 2
604
G-protein-signaling modulator 2
124
2.0
66
0.74
GPSM2GPSM2Q8VDU0Q8VDU0celldivisionestablishmentofmitoticspindleorientationmaintenanceofcentrosomelocationmitoticspindleorganizationpositiveregulationofproteinlocalizationtocellcortexpositiveregulationofspindleassemblyRanproteinsignaltransductionregulationofmitoticspindleorganization
Growth/differentiation factor 8
340
Growth/differentiation factor 8
340
2.0
73
0.67
GDF8GDF8O08689O08689cellularresponsetodexamethasonestimulusmusclecellcellularhomeostasismyoblastmigrationinvolvedinskeletalmuscleregenerationnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofkinaseactivitynegativeregulationofmusclehypertrophynegativeregulationofmyoblastdifferentiationnegativeregulationofmyoblastproliferationnegativeregulationofproteinkinaseBsignalingnegativeregulationofsatellitecelldifferentiationnegativeregulationofskeletalmusclesatellitecellproliferationnegativeregulationofskeletalmuscletissuegrowthovulationcycleprocesspositiveregulationoflamellipodiumassemblypositiveregulationofmacrophagechemotaxispositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionDNA-templatedresponsetoelectricalstimulusresponsetoestrogenresponsetoethanolresponsetogravityresponsetoheatresponsetomuscleactivityresponsetotestosteroneskeletalmuscleatrophySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Ig gamma-2A chain C region, A allele
107
Ig gamma-2A chain C region, A allele
107
2.0
31
1.58
GCAAGCAAP01863P01863BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationresponsetobacterium
Lysosomal alpha-mannosidase
414
Lysosomal alpha-mannosidase
474
2.1
77
0.63
MA2B1MA2B1Q29451Q29451mannosemetabolicprocessproteinmodificationprocess
Parkinson disease protein 7
53
Parkinson disease protein 7
53
2.1
73
0.66
1
✔PARK7PARK7Q99497Q99497activationofproteinkinaseBactivityadultlocomotorybehaviorautophagycellulardetoxificationofaldehydecellulardetoxificationofmethylglyoxalcellularresponsetoglyoxalcellularresponsetohydrogenperoxidecellularresponsetooxidativestressdetectionofoxidativestressdetoxificationofcopperiondetoxificationofmercuryionDNArepairdopamineuptakeinvolvedinsynaptictransmissionglucosehomeostasisglutathionedeglycationglycolatebiosyntheticprocessglyoxalmetabolicprocessguaninedeglycationguaninedeglycationglyoxalremovalguaninedeglycationmethylglyoxalremovalhistonemodificationhydrogenperoxidemetabolicprocessinflammatoryresponseinsulinsecretionlactatebiosyntheticprocessmembranedepolarizationmembranehyperpolarizationmethylglyoxalcatabolicprocesstolactatemethylglyoxalmetabolicprocessmitochondrionorganizationnegativeregulationofapoptoticprocessnegativeregulationofcelldeathnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaynegativeregulationofdeath-inducingsignalingcomplexassemblynegativeregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofhydrogenperoxide-inducedneurondeathnegativeregulationofhydrogenperoxide-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofneuronapoptoticprocessnegativeregulationofneurondeathnegativeregulationofnitrosativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofoxidativestress-inducedcelldeathnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofproteinacetylationnegativeregulationofproteinbindingnegativeregulationofproteinexportfromnucleusnegativeregulationofproteinK48-linkeddeubiquitinationnegativeregulationofproteinkinaseactivitynegativeregulationofproteinphosphorylationnegativeregulationofproteinsumoylationnegativeregulationofproteinubiquitinationnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofTRAIL-activatedapoptoticsignalingpathwaynegativeregulationofubiquitin-proteintransferaseactivitynegativeregulationofubiquitin-specificproteaseactivitypeptidyl-argininedeglycationpeptidyl-cysteinedeglycationpeptidyl-lysinedeglycationpositiveregulationofacuteinflammatoryresponsetoantigenicstimuluspositiveregulationofandrogenreceptoractivitypositiveregulationofautophagyofmitochondrionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofdopaminebiosyntheticprocesspositiveregulationofgeneexpressionpositiveregulationofinterleukin-8productionpositiveregulationofL-dopabiosyntheticprocesspositiveregulationofL-dopadecarboxylaseactivitypositiveregulationofmitochondrialelectrontransportNADHtoubiquinonepositiveregulationofNAD(P)Hoxidaseactivitypositiveregulationofoxidativephosphorylationuncoupleractivitypositiveregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofprotein-containingcomplexassemblypositiveregulationofpyrroline-5-carboxylatereductaseactivitypositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofsuperoxidedismutaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftyrosine3-monooxygenaseactivityproteindeglycationglyoxalremovalproteindeglycationmethylglyoxalremovalproteindeglycosylationproteinstabilizationproteolysisRasproteinsignaltransductionregulationofandrogenreceptorsignalingpathwayregulationofhistoneacetylationregulationofhistoneubiquitinationregulationofinflammatoryresponseregulationofmitochondrialmembranepotentialregulationofneuronapoptoticprocessregulationofsupramolecularfiberorganizationresponsetooxidativestresssinglefertilization
Kelch-like ECH-associated protein 1
434
Kelch-like ECH-associated protein 1
434
2.1
76
0.64
KEAP1KEAP1Q9Z2X8Q9Z2X8cellularresponsetocarbohydratestimuluscellularresponsetointerleukin-4cellularresponsetooxidativestresscytoplasmicsequesteringoftranscriptionfactorinuteroembryonicdevelopmentnegativeregulationofgeneexpressionproteinubiquitinationregulationofautophagyregulationofepidermalcelldifferentiationregulationoftranscriptionDNA-templatedubiquitin-dependentproteincatabolicprocess
Amiloride-sensitive amine oxidase [copper-containing]
736
Amiloride-sensitive amine oxidase [copper-containing]
736
2.1
52
0.93
AOC1AOC1P19801P19801aminemetabolicprocesscellularresponsetoazidecellularresponsetocopperioncellularresponsetocopperionstarvationcellularresponsetoheparincellularresponsetohistamineputrescinemetabolicprocessresponsetoantibiotic
Ubiquitin-like protein ISG15
78
Ubiquitin-like protein ISG15
78
2.1
49
0.98
ISG15ISG15P05161P05161defenseresponsetobacteriumdefenseresponsetovirusintegrin-mediatedsignalingpathwayISG15-proteinconjugationmodification-dependentproteincatabolicprocessnegativeregulationofproteinubiquitinationnegativeregulationoftypeIinterferon-mediatedsignalingpathwaynegativeregulationofviralgenomereplicationpositiveregulationofbonemineralizationpositiveregulationoferythrocytedifferentiationpositiveregulationofinterferon-betaproductionpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-10productionpositiveregulationofproteinoligomerizationproteinlocalizationtomitochondrionregulationofinterferon-gammaproductionresponsetotypeIinterferonresponsetovirus
Coagulation factor IX
291
Coagulation factor IX
133
2.0
84
0.58
FA9FA9P16293P16293bloodcoagulationproteolysiszymogenactivation
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
166
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
166
2.6
92
0.41
MTDCMTDCP13995P13995folicacidmetabolicprocesstetrahydrofolateinterconversiontetrahydrofolatemetabolicprocess
Poly(rC)-binding protein 1
54
Poly(rC)-binding protein 1
54
2.0
51
0.96
PCBP1PCBP1Q15365Q15365positiveregulationoftranscriptionbyRNApolymeraseIIregulationofgeneexpressionregulationofRNAmetabolicprocessviralRNAgenomereplication
Growth/differentiation factor 11
371
Growth/differentiation factor 11
371
2.0
79
0.62
GDF11GDF11O95390O95390amacrinecelldifferentiationcamera-typeeyemorphogenesiscellpopulationproliferationmesodermdevelopmentmetanephrosdevelopmentnegativeregulationofamacrinecelldifferentiationnegativeregulationofcellpopulationproliferationnervoussystemdevelopmentpositiveregulationofpathway-restrictedSMADproteinphosphorylationroofofmouthdevelopmentskeletalsystemdevelopmentSMADproteinsignaltransductionspinalcordanterior/posteriorpatterningtypeBpancreaticcellmaturationuretericbuddevelopment
Ubiquitin carboxyl-terminal hydrolase 7
576
Ubiquitin carboxyl-terminal hydrolase 7
576
2.0
76
0.64
UBP7UBP7Q93009Q93009histoneH2BconservedC-terminallysinedeubiquitinationmaintenanceofDNAmethylationmonoubiquitinatedproteindeubiquitinationnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofDNAdemethylationproteindeubiquitinationproteinK63-linkeddeubiquitinationproteinstabilizationproteinubiquitinationregulationofcircadianrhythmregulationofDNA-bindingtranscriptionfactoractivityregulationofgluconeogenesisregulationofproteinstabilityregulationofretrogradetransportendosometoGolgiregulationofsignaltransductionbyp53classmediatorregulationoftelomerecappingrhythmicprocesstranscription-couplednucleotide-excisionrepairubiquitin-dependentproteincatabolicprocess
Fibroblast growth factor receptor 2
491
Fibroblast growth factor receptor 2
491
2.9
40
0.86
FGFR2FGFR2P21802P21802angiogenesisanimalorganmorphogenesisapoptoticprocessaxonogenesisbonedevelopmentbonemineralizationbonemorphogenesisbranchelongationinvolvedinsalivaryglandmorphogenesisbranchinginvolvedinlabyrinthinelayermorphogenesisbranchinginvolvedinprostateglandmorphogenesisbranchinginvolvedinsalivaryglandmorphogenesisbranchingmorphogenesisofanervebudelongationinvolvedinlungbranchingcellfatecommitmentcell-cellsignalingcellularresponsetoretinoicacidcellularresponsetotransforminggrowthfactorbetastimulusdigestivetractdevelopmentembryoniccranialskeletonmorphogenesisembryonicdigestivetractmorphogenesisembryonicorgandevelopmentembryonicorganmorphogenesisembryonicpatternspecificationendochondralbonegrowthepidermismorphogenesisepithelialcelldifferentiationepithelialcellproliferationinvolvedinsalivaryglandmorphogenesisepithelialtomesenchymaltransitionfibroblastgrowthfactorreceptorsignalingpathwayfibroblastgrowthfactorreceptorsignalingpathwayinvolvedinhemopoiesisfibroblastgrowthfactorreceptorsignalingpathwayinvolvedinmammaryglandspecificationfibroblastgrowthfactorreceptorsignalingpathwayinvolvedinnegativeregulationofapoptoticprocessinbonemarrowcellfibroblastgrowthfactorreceptorsignalingpathwayinvolvedinorbitofrontalcortexdevelopmentfibroblastgrowthfactorreceptorsignalingpathwayinvolvedinpositiveregulationofcellproliferationinbonemarrowglandmorphogenesishairfolliclemorphogenesisinuteroembryonicdevelopmentinnerearmorphogenesislacrimalglanddevelopmentlateralsproutingfromanepitheliumlimbbudformationlungalveolusdevelopmentlungdevelopmentlunglobemorphogenesislung-associatedmesenchymedevelopmentmammaryglandbudformationmembranousseptummorphogenesismesenchymalcelldifferentiationmesenchymalcelldifferentiationinvolvedinlungdevelopmentmesenchymalcellproliferationinvolvedinlungdevelopmentmesodermalcelldifferentiationmidbraindevelopmentmorphogenesisofembryonicepitheliumnegativeregulationofkeratinocyteproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIodontogenesisorbitofrontalcortexdevelopmentorgangrowthoticvesicleformationoutflowtractseptummorphogenesispeptidyl-tyrosinephosphorylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellcyclepositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialcellproliferationinvolvedinlungmorphogenesispositiveregulationofERK1andERK2cascadepositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmesenchymalcellproliferationpositiveregulationofphospholipaseactivitypositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofWntsignalingpathwaypost-embryonicdevelopmentprostateepithelialcordarborizationinvolvedinprostateglandularacinusmorphogenesisprostateepithelialcordelongationprostateglandmorphogenesisproteinautophosphorylationpyramidalneurondevelopmentregulationofERK1andERK2cascaderegulationofmorphogenesisofabranchingstructureregulationofosteoblastdifferentiationregulationofosteoblastproliferationregulationofsmoothmusclecelldifferentiationregulationofsmoothenedsignalingpathwayreproductivestructuredevelopmentresponsetoethanolresponsetolipopolysaccharideskeletalsystemmorphogenesissquamousbasalepithelialstemcelldifferentiationinvolvedinprostateglandacinusdevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathwayuretericbuddevelopmentventricularcardiacmuscletissuemorphogenesisventricularzoneneuroblastdivisionwoundhealing
Complement C3
1010
Complement C3
1010
2.9
89
0.38
CO3CO3P01024P01024amyloid-betaclearancecellsurfacereceptorsignalingpathwayinvolvedincell-cellsignalingcomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitycomplement-mediatedsynapsepruningfattyacidmetabolicprocessGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseneuronremodelingopsonizationoviductepitheliumdevelopmentpositiveregulationofactivationofmembraneattackcomplexpositiveregulationofangiogenesispositiveregulationofapoptoticcellclearancepositiveregulationofapoptoticprocessinanotherorganismpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofglucosetransmembranetransportpositiveregulationofimmuneresponsepositiveregulationoflipidstoragepositiveregulationofopsonizationpositiveregulationofphagocytosispositiveregulationofphagocytosisengulfmentpositiveregulationofproteinphosphorylationpositiveregulationofreceptor-mediatedendocytosispositiveregulationoftypeIIahypersensitivitypositiveregulationofvascularendothelialgrowthfactorproductionproteolysisregulationofcomplementactivationregulationofcomplementactivationalternativepathwayregulationoftriglyceridebiosyntheticprocessresponsetobacteriumsignaltransductionvertebrateeye-specificpatterning
Antiviral innate immune response receptor RIG-I
829
Antiviral innate immune response receptor RIG-I
829
3.0
67
0.51
DDX58DDX58O95786O95786antiviralinnateimmuneresponsecellularresponsetoexogenousdsRNAcytoplasmicpatternrecognitionreceptorsignalingpathwayinresponsetovirusdefenseresponsetovirusdetectionofvirusgeneexpressioninnateimmuneresponsepositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofgeneexpressionpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofmyeloiddendriticcellcytokineproductionpositiveregulationofresponsetocytokinestimuluspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionregulationofcellmigrationregulationoftypeIIIinterferonproductionresponsetoexogenousdsRNAresponsetovirusRIG-Isignalingpathway
Nuclear receptor subfamily 1 group I member 3
221
Nuclear receptor subfamily 1 group I member 3
221
2.8
71
0.5
NR1I3NR1I3O35627O35627celldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedosteoblastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templated
Bile acid receptor
446
Bile acid receptor
446
3.0
77
0.44
NR1H4NR1H4Q96RI1Q96RI1bileacidmetabolicprocessbileacidsignalingpathwaycelldifferentiationcell-celljunctionassemblycellularglucosehomeostasiscellularresponsetobileacidcellularresponsetofattyacidcellularresponsetolipopolysaccharidecellularresponsetoorganonitrogencompoundcellulartriglyceridehomeostasischolesterolhomeostasisdefenseresponsetobacteriumfattyacidhomeostasishistoneH3-R17methylationinflammatoryresponseinnateimmuneresponseintracellularbileacidreceptorsignalingpathwayintracellularreceptorsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofinflammatoryresponsenegativeregulationofinterferon-gammaproductionnegativeregulationofinterleukin-1productionnegativeregulationofinterleukin-2productionnegativeregulationofinterleukin-6productionnegativeregulationofmonocytechemotacticprotein-1productionnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftumornecrosisfactorproductionnegativeregulationoftumornecrosisfactor-mediatedsignalingpathwaynegativeregulationofvery-low-densitylipoproteinparticleremodelingnitrogencataboliteactivationoftranscriptionfromRNApolymeraseIIpromoterNotchsignalingpathwaypositiveregulationofadiposetissuedevelopmentpositiveregulationofammoniaassimilationcyclepositiveregulationofglutamatemetabolicprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofinterleukin-17productionpositiveregulationofphosphatidicacidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationofbileacidbiosyntheticprocessregulationofcholesterolmetabolicprocessregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulusregulationoflow-densitylipoproteinparticleclearanceregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionDNA-templatedregulationofureametabolicprocesstoll-likereceptor4signalingpathwaytoll-likereceptor9signalingpathwaytranscriptionbyRNApolymeraseII
Tumor necrosis factor ligand superfamily member 10
230
Tumor necrosis factor ligand superfamily member 10
230
3.0
82
0.41
TNF10TNF10P50591P50591apoptoticprocesscell-cellsignalingimmuneresponsemalegonaddevelopmentpositiveregulationofapoptoticprocesspositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofreleaseofcytochromecfrommitochondriaresponsetoinsulinsignaltransduction
D-3-phosphoglycerate dehydrogenase
116
D-3-phosphoglycerate dehydrogenase
116
3.0
96
0.35
SERASERAO43175O43175braindevelopmentG1toG0transitiongamma-aminobutyricacidmetabolicprocessglialcelldevelopmentglutaminemetabolicprocessglycinemetabolicprocessL-serinebiosyntheticprocessneuraltubedevelopmentneuronprojectiondevelopmentregulationofgeneexpressionspinalcorddevelopmenttaurinemetabolicprocessthreoninemetabolicprocess
ADP-ribosylation factor-binding protein GGA1
77
ADP-ribosylation factor-binding protein GGA1
77
2.5
74
0.54
GGA1GGA1Q9UJY5Q9UJY5GolgitoplasmamembraneproteintransportGolgitoplasmamembranetransportintracellularproteintransportpositiveregulationofproteincatabolicprocessproteincatabolicprocessproteinlocalizationproteinlocalizationtocellsurfaceproteinlocalizationtociliarymembraneretrogradetransportendosometoGolgitoxintransport
Retinoblastoma-associated protein
438
Retinoblastoma-associated protein
438
2.7
60
0.62
RBRBP06400P06400aorticvalvemorphogenesiscelldifferentiationcelldivisioncellmorphogenesisinvolvedinneurondifferentiationcellularresponsetoinsulinstimuluscellularresponsetoxenobioticstimuluschondrocytedifferentiationchromatinremodelingdigestivetractdevelopmentenucleateerythrocytedifferentiationepithelialcellproliferationglialcellapoptoticprocessglialcellproliferationhepatocyteapoptoticprocessheterochromatinassemblymaintenanceofmitoticsisterchromatidcohesionmyoblastdifferentiationnegativeregulationofapoptoticsignalingpathwaynegativeregulationofcellcyclenegativeregulationofcellgrowthnegativeregulationofcold-inducedthermogenesisnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofepithelialcellproliferationnegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofgeneexpressionnegativeregulationofglialcellproliferationnegativeregulationofhepatocyteapoptoticprocessnegativeregulationofinflammatoryresponsenegativeregulationofmyofibroblastdifferentiationnegativeregulationofproteinkinaseactivitynegativeregulationofproteinserine/threoninekinaseactivitynegativeregulationofsmoothenedsignalingpathwaynegativeregulationoftau-proteinkinaseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptioninvolvedinG1/StransitionofmitoticcellcyclenegativeregulationoftranscriptionDNA-templatedneuronapoptoticprocessneuronmaturationneuronprojectiondevelopmentpositiveregulationofcollagenfibrilorganizationpositiveregulationofextracellularmatrixorganizationpositiveregulationofmacrophagedifferentiationpositiveregulationofmitoticmetaphase/anaphasetransitionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingproteinlocalizationtochromosomecentromericregionRasproteinsignaltransductionregulationofcellcycleregulationofcentromerecomplexassemblyregulationofcohesinloadingregulationoflipidkinaseactivityregulationofmitoticcellcycleregulationoftranscriptionDNA-templatedsisterchromatidbiorientationskeletalmusclecelldifferentiationsmoothenedsignalingpathwayspermatogenesisstriatedmusclecelldifferentiationtissuehomeostasistranscriptionbyRNApolymeraseII
Regulator of G-protein signaling 3
315
Regulator of G-protein signaling 3
315
2.7
77
0.48
RGS3RGS3P49796P49796Gprotein-coupledreceptorsignalingpathwaynegativeregulationofsignaltransductionregulationofGprotein-coupledreceptorsignalingpathwaysignaltransduction
ETS translocation variant 1
416
ETS translocation variant 1
416
2.8
60
0.6
ETV1ETV1P50549P50549axonguidancecelldifferentiationmechanosensorybehaviormuscleorgandevelopmentperipheralnervoussystemneurondevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseII
Histone-lysine N-methyltransferase 2A
1575
Histone-lysine N-methyltransferase 2A
1575
2.7
61
0.61
KMT2AKMT2AQ03164Q03164anterior/posteriorpatternspecificationapoptoticprocesschromatinorganizationcircadianregulationofgeneexpressiondefinitivehemopoiesisDNAmethylationembryonichemopoiesisexplorationbehaviorfibroblastproliferationhistoneH3-K4dimethylationhistoneH3-K4methylationhistoneH3-K4monomethylationhistoneH3-K4trimethylationhistoneH4-K16acetylationhomeostasisofnumberofcellswithinatissuemembranedepolarizationnegativeregulationofDNAmethylationnegativeregulationoffibroblastproliferationpeptidyl-lysinemonomethylationpositiveregulationofhistoneH3-K4methylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationoftransporteractivitypost-embryonicdevelopmentprotein-containingcomplexassemblyregulationofhistoneH3-K14acetylationregulationofhistoneH3-K27acetylationregulationofhistoneH3-K9acetylationregulationofshort-termneuronalsynapticplasticityresponsetopotassiumionspleendevelopmentvisuallearning
Procathepsin L
269
Procathepsin L
322
2.3
65
0.66
CATL1CATL1P07711P07711adaptiveimmuneresponseantigenprocessingandpresentationantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofpeptideantigenCD4-positivealpha-betaTcelllineagecommitmentcellularresponsetothyroidhormonestimuluscollagencatabolicprocesselastincatabolicprocessenkephalinprocessingfusionofvirusmembranewithhostendosomemembranefusionofvirusmembranewithhostplasmamembraneimmuneresponsemacrophageapoptoticprocessproteinautoprocessingproteolysisproteolysisinvolvedinproteincatabolicprocessreceptor-mediatedendocytosisofvirusbyhostcellviralentryintohostcellzymogenactivation
Zinc finger protein 276
196
Zinc finger protein 276
196
2.2
62
0.72
A0A5F9DAT3A0A5F9DAT3A0A5F9DAT3A0A5F9DAT3
Angiotensinogen
340
Angiotensinogen
340
2.6
65
0.6
ANGTANGTP01015P01015activationofNF-kappaB-inducingkinaseactivityactivationofphospholipaseCactivityagingaldosteronesecretionangiotensin-activatedsignalingpathwayangiotensin-mediateddrinkingbehaviorangiotensin-mediatedvasoconstrictioninvolvedinregulationofsystemicarterialbloodpressurearterysmoothmusclecontractionassociativelearningastrocyteactivationbloodvesseldevelopmentbrainrenin-angiotensinsystembranchinginvolvedinuretericbudmorphogenesiscellgrowthinvolvedincardiacmusclecelldevelopmentcellsurfacereceptorsignalingpathwaycell-matrixadhesioncellularresponsetoangiotensincellularresponsetomechanicalstimuluscellularsodiumionhomeostasisdrinkingbehaviorERK1andERK2cascadeestablishmentofblood-nervebarrierextracellularmatrixorganizationfemalepregnancyfibroblastproliferationGprotein-coupledreceptorsignalingpathwayhormonemetabolicprocesskidneydevelopmentnegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofendopeptidaseactivitynegativeregulationofMAPkinaseactivitynegativeregulationofneuronapoptoticprocessnegativeregulationofneurotrophinTRKreceptorsignalingpathwaynegativeregulationoftissueremodelingoperantconditioningovarianfollicleruptureperistalsispositiveregulationofactivationofJanuskinaseactivitypositiveregulationofbloodpressurepositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcardiacmusclehypertrophypositiveregulationofcatalyticactivitypositiveregulationofcellpopulationproliferationpositiveregulationofcholesterolesterificationpositiveregulationofCoA-transferaseactivitypositiveregulationofcytokineproductionpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofendothelialcellmigrationpositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofextracellularmatrixconstituentsecretionpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationoffattyacidbiosyntheticprocesspositiveregulationoffibroblastproliferationpositiveregulationofgapjunctionassemblypositiveregulationofgeneexpressionpositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofL-arginineimportacrossplasmamembranepositiveregulationofL-lysineimportacrossplasmamembranepositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofMAPKcascadepositiveregulationofmulticellularorganismgrowthpositiveregulationofneuronprojectiondevelopmentpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationoforgangrowthpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseCactivitypositiveregulationofproteintyrosinekinaseactivitypositiveregulationofrenalsodiumexcretionpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularassociatedsmoothmusclecellmigrationpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinimportintonucleusregulationofapoptoticprocessregulationofbloodpressureregulationofcalciumiontransportregulationofcardiacconductionregulationofextracellularmatrixassemblyregulationofgeneexpressionregulationofheartrateregulationofinflammatoryresponseregulationoflong-termneuronalsynapticplasticityregulationofnorepinephrinesecretionregulationofrenaloutputbyangiotensinregulationofrenalsodiumexcretionregulationofsystemicarterialbloodpressurebycirculatoryrenin-angiotensinregulationoftransmissionofnerveimpulserenalresponsetobloodflowinvolvedincirculatoryrenin-angiotensinregulationofsystemicarterialbloodpressurerenalsystemprocessrenin-angiotensinregulationofaldosteroneproductionresponsetocoldresponsetoestradiolresponsetomuscleactivityinvolvedinregulationofmuscleadaptationresponsetosaltstresssmoothmusclecelldifferentiationsmoothmusclecellproliferationstress-activatedMAPKcascadeuterinesmoothmusclecontractionvasoconstrictionvasodilationvasopressinsecretion
Cyclin-A2
327
Cyclin-A2
327
2.6
74
0.52
CCNA2CCNA2P20248P20248animalorganregenerationcellcycleG1/Sphasetransitioncelldivisioncellularresponsetococainecellularresponsetoestradiolstimuluscellularresponsetohypoxiacellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetoleptinstimuluscellularresponsetoluteinizinghormonestimuluscellularresponsetonitricoxidecellularresponsetoplatelet-derivedgrowthfactorstimuluscochleadevelopmentG2/MtransitionofmitoticcellcyclehistonephosphorylationmitoticcellcyclephasetransitionpositiveregulationoffibroblastproliferationpositiveregulationoftranscriptionDNA-templatedRasproteinsignaltransductionregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofDNAreplicationresponsetoglucagontranscriptionDNA-templated
Isoform L-VEGF206 of Vascular endothelial growth factor A
266
Isoform L-VEGF206 of Vascular endothelial growth factor A
257
2.2
71
0.63
VEGFAVEGFAP15692-14P15692-14
Poly(A)-specific ribonuclease PARN
108
Poly(A)-specific ribonuclease PARN
108
2.2
81
0.56
PARNPARNO95453O95453"boxH/ACARNA3-endprocessing"femalegametegenerationmiRNAcatabolicprocessncRNAdeadenylationnuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecaynuclear-transcribedmRNApoly(A)tailshortening"polyadenylation-dependentsnoRNA3-endprocessing"positiveregulationoftelomeraseactivitypositiveregulationoftelomeremaintenanceviatelomeraseregulationoftelomeraseRNAlocalizationtoCajalbodyRNAmodificationRNAphosphodiesterbondhydrolysisexonucleolytictelomeraseRNAstabilization
Ganglioside-induced differentiation-associated protein 1
88
Ganglioside-induced differentiation-associated protein 1
88
2.0
67
0.73
GDAP1GDAP1Q8TB36Q8TB36cellularresponsetovitaminDglutathionemetabolicprocessmitochondrialfissionmitochondrialfusionproteintargetingtomitochondrionresponsetoretinoicacid
Xaa-Pro dipeptidase
58
Xaa-Pro dipeptidase
158
2.0
63
0.78
1
✔PEPDPEPDP12955P12955cellularaminoacidmetabolicprocesscollagencatabolicprocessproteolysis
Diphosphoinositol polyphosphate phosphohydrolase 2
130
Diphosphoinositol polyphosphate phosphohydrolase 2
130
2.0
51
0.96
NUDT4NUDT4Q8R2U6Q8R2U6"adenosine5-(hexahydrogenpentaphosphate)catabolicprocess"diadenosinehexaphosphatecatabolicprocessdiadenosinepentaphosphatecatabolicprocessdiphosphoinositolpolyphosphatemetabolicprocess
Cytoglobin
83
Cytoglobin
38
2.0
88
0.56
CYGBCYGBQ8WWM9Q8WWM9fattyacidoxidationnegativeregulationofcollagenbiosyntheticprocessnegativeregulationoffibroblastmigrationnegativeregulationofhepaticstellatecellactivationoxygentransportresponsetohypoxiaresponsetooxidativestress
Signal recognition particle receptor subunit alpha
621
Signal recognition particle receptor subunit alpha
621
2.0
66
0.74
SRPRASRPRAP08240P08240cotranslationalproteintargetingtomembraneproteintargetingproteintargetingtoERSRP-dependentcotranslationalproteintargetingtomembranesignalsequencerecognition
PDZ and LIM domain protein 4
44
PDZ and LIM domain protein 4
44
2.0
89
0.55
PDLI4PDLI4P50479P50479actincytoskeletonorganizationactincytoskeletonreorganizationexcitatorychemicalsynaptictransmissionheartdevelopmentmusclestructuredevelopment
Amyloid beta precursor protein binding family B member 1
661
Amyloid beta precursor protein binding family B member 1
661
2.0
90
0.54
APBB1APBB1O00213O00213apoptoticprocessaxonogenesiscellularresponsetoDNAdamagestimuluschromatinorganizationhistoneH4acetylationnegativeregulationofcellcycleG1/SphasetransitionnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofapoptoticprocesspositiveregulationofproteinsecretionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationoftranscriptionDNA-templatedsignaltransductionsmoothmusclecontraction
Growth/differentiation factor 15
273
Growth/differentiation factor 15
273
2.0
89
0.55
GDF15GDF15Q99988Q99988BMPsignalingpathwaycell-cellsignalingglialcell-derivedneurotrophicfactorreceptorsignalingpathwaynegativeregulationofgrowthhormonereceptorsignalingpathwaynegativeregulationofmulticellularorganismgrowthpositiveregulationofMAPKcascadepositiveregulationofmyoblastfusionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinkinaseBsignalingreductionoffoodintakeinresponsetodietaryexcesssignaltransductionSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Sorting nexin-24
52
Sorting nexin-24
52
2.0
70
0.7
SNX24SNX24Q9Y343Q9Y343proteintransport
Endonuclease G, mitochondrial
110
Endonuclease G, mitochondrial
110
2.0
74
0.66
NUCGNUCGO08600O08600agingapoptoticDNAfragmentationcellularresponsetocalciumioncellularresponsetoglucosestimuluscellularresponsetohypoxiaDNAcatabolicprocessinuteroembryonicdevelopmentmitochondrialDNAcatabolicprocessnegativeregulationofTORsignalingneurondeathinresponsetooxidativestresspositiveregulationofapoptoticDNAfragmentationpositiveregulationofapoptoticprocesspositiveregulationofautophagypositiveregulationofhydrogenperoxide-mediatedprogrammedcelldeathpositiveregulationofmitochondrialDNAreplicationpositiveregulationofresponsetoDNAdamagestimulusresponsetoantibioticresponsetoestradiolresponsetomechanicalstimulusresponsetotumornecrosisfactor
Prorelaxin H2
172
Prorelaxin H2
35
2.1
55
0.88
REL2REL2P04090P04090femalepregnancypositiveregulationofangiogenesispositiveregulationofgeneexpressionregulationofcatalyticactivity
Zinc fingers and homeoboxes protein 2
494
Zinc fingers and homeoboxes protein 2
494
2.0
65
0.75
ZHX2ZHX2Q9Y6X8Q9Y6X8mRNAcatabolicprocessnegativeregulationofneurondifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedregulationoftranscriptionbyRNApolymeraseIIretinalbipolarneurondifferentiationsomaticstemcellpopulationmaintenance
Thioredoxin
62
Thioredoxin
62
2.0
67
0.73
THIOTHIOP10599P10599activationofproteinkinaseBactivitycellredoxhomeostasisnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiation
UBX domain-containing protein 7
478
UBX domain-containing protein 7
478
2.1
67
0.73
UBXN7UBXN7O94888O94888proteasome-mediatedubiquitin-dependentproteincatabolicprocess
Gamma-crystallin S
25
Gamma-crystallin S
25
2.0
79
0.62
CRYGSCRYGSO35486O35486lensdevelopmentincamera-typeeyemorphogenesisofanepitheliumvisualperception
Asparagine synthetase [glutamine-hydrolyzing]
18
Asparagine synthetase [glutamine-hydrolyzing]
18
2.0
88
0.55
ASNSASNSP08243P08243asparaginebiosyntheticprocesscellularresponsetoglucosestarvationglutaminemetabolicprocessL-asparaginebiosyntheticprocessnegativeregulationofapoptoticprocesspositiveregulationofmitoticcellcycle
Caspase-1
136
Caspase-1
362
2.0
59
0.83
CASP1CASP1P29466P29466apoptoticprocesscellularresponsetointerferon-gammacellularresponsetolipopolysaccharidecellularresponsetomechanicalstimuluscellularresponsetoorganicsubstancecytokineprecursorprocessingdefenseresponsetovirusicosanoidbiosyntheticprocessosmosensorysignalingpathwaypatternrecognitionreceptorsignalingpathwaypositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayproteinautoprocessingproteolysispyroptosisregulationofapoptoticprocessregulationofinflammatoryresponsesignaltransductionsignalingreceptorligandprecursorprocessing
Alpha-2-macroglobulin
278
Alpha-2-macroglobulin
431
2.0
39
1.25
A2MGA2MGP01023P01023acuteinflammatoryresponsetoantigenicstimulusacute-phaseresponseembryonicliverdevelopmentluteinizationnegativeregulationofcomplementactivationlectinpathwayresponsetocarbondioxideresponsetoglucocorticoidresponsetonutrientresponsetoprostaglandinEstemcelldifferentiation
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
106
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
106
2.0
98
0.5
GPTGPTQ9H3H5Q9H3H5dolicholmetabolicprocessdolichol-linkedoligosaccharidebiosyntheticprocessproteinN-linkedglycosylationUDP-N-acetylglucosaminemetabolicprocess
Vascular endothelial growth factor A
86
Vascular endothelial growth factor A
77
2.0
80
0.61
VEGFAVEGFAQ96NW5Q96NW5activationofproteinkinaseactivityangiogenesisarterymorphogenesisbasophilchemotaxisbranchinginvolvedinbloodvesselmorphogenesiscamera-typeeyemorphogenesiscardiacmusclecelldevelopmentcardiacvascularsmoothmusclecelldevelopmentcellmaturationcellmigrationinvolvedinsproutingangiogenesiscellularresponsetohypoxiacellularresponsetovascularendothelialgrowthfactorstimuluscellularstressresponsetoacidchemicalcommissuralneuronaxonguidancecoronaryarterymorphogenesiscoronaryveinmorphogenesisdopaminergicneurondifferentiationendothelialcellchemotaxisepithelialcelldifferentiationeyephotoreceptorcelldevelopmentheartmorphogenesisinuteroembryonicdevelopmentinductionofpositivechemotaxiskidneydevelopmentlactationlungdevelopmentlymphvesselmorphogenesismacrophagedifferentiationmammaryglandalveolusdevelopmentmesodermdevelopmentmonocytedifferentiationmotorneuronmigrationnegativeregulationofadherensjunctionorganizationnegativeregulationofapoptoticprocessnegativeregulationofblood-brainbarrierpermeabilitynegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofestablishmentofendothelialbarriernegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentoutflowtractmorphogenesisovarianfollicledevelopmentpositivechemotaxispositiveregulationofangiogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelladhesionpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellmigrationbyvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofcellproliferationbyVEGF-activatedplateletderivedgrowthfactorreceptorsignalingpathwaypositiveregulationofcold-inducedthermogenesispositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialtubeformationpositiveregulationofERK1andERK2cascadepositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofhistonedeacetylaseactivitypositiveregulationofleukocytemigrationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmastcellchemotaxispositiveregulationofneuroblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofpositivechemotaxispositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinkinaseCsignalingpositiveregulationofproteinkinaseDsignalingpositiveregulationofproteinlocalizationtoearlyendosomepositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorinternalizationpositiveregulationofretinalganglioncellaxonguidancepositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftrophoblastcellmigrationpositiveregulationofvascularpermeabilitypost-embryoniccamera-typeeyedevelopmentprimitiveerythrocytedifferentiationregulationofcellshaperegulationofnitricoxidemediatedsignaltransductionregulationofretinalganglioncellaxonguidanceregulationoftranscriptionbyRNApolymeraseIIresponsetohypoxiasproutingangiogenesissurfactanthomeostasistubeformationvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorreceptor-2signalingpathwayvascularendothelialgrowthfactorsignalingpathwayvascularwoundhealingvasculogenesisVEGF-activatedneuropilinsignalingpathway
Set1/Ash2 histone methyltransferase complex subunit ASH2
581
Set1/Ash2 histone methyltransferase complex subunit ASH2
581
2.0
48
1.02
ASH2LASH2LQ9UBL3Q9UBL3cellularresponsetoDNAdamagestimuluschromatinorganizationhemopoiesishistoneH3-K4methylationpositiveregulationofcellpopulationproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIresponsetoestrogen
Fibroblast growth factor 2
211
Fibroblast growth factor 2
211
2.0
74
0.66
FGF2FGF2P09038P09038agingangiogenesisinvolvedincoronaryvascularmorphogenesisanimalorganmorphogenesisbranchinginvolvedinuretericbudmorphogenesiscanonicalWntsignalingpathwaycelldifferentiationcellmigrationinvolvedinsproutingangiogenesiscellularresponsetomechanicalstimuluscerebellargranulecellprecursorproliferationchemotaxischondroblastdifferentiationcorticotropinhormonesecretingcelldifferentiationembryodevelopmentendinginbirthoregghatchingembryonicmorphogenesisendothelialcellproliferationERK1andERK2cascadefibroblastgrowthfactorreceptorsignalingpathwayglialcelldifferentiationgrowthfactordependentregulationofskeletalmusclesatellitecellproliferationhyaluronancatabolicprocessinnerearauditoryreceptorcelldifferentiationinositolphosphatebiosyntheticprocesslungdevelopmentlymphaticendothelialcellmigrationmammaryglandepithelialcelldifferentiationnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcelldeathnegativeregulationoffibroblastgrowthfactorreceptorsignalingpathwaynegativeregulationoffibroblastmigrationnegativeregulationofgeneexpressionnegativeregulationofstemcellproliferationnegativeregulationofwoundhealingnervoussystemdevelopmentneuroblastproliferationorganinductionosteoblastdifferentiationparacrinesignalingphosphatidylinositolbiosyntheticprocesspositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecellproliferationpositiveregulationofcelldivisionpositiveregulationofcellfatespecificationpositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofcerebellargranulecellprecursorproliferationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellchemotaxispositiveregulationofendothelialcellchemotaxistofibroblastgrowthfactorpositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialtubeformationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofinnerearauditoryreceptorcelldifferentiationpositiveregulationoflensfibercelldifferentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmiRNAtranscriptionpositiveregulationofneuroblastproliferationpositiveregulationofneuroepithelialcelldifferentiationpositiveregulationofosteoblastdifferentiationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphospholipaseCactivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofsproutingangiogenesispositiveregulationofstemcelldifferentiationpositiveregulationofstemcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofvascularendothelialcellproliferationproteinkinaseBsignalingRasproteinsignaltransductionregulationofangiogenesisregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisregulationofcellcycleregulationofcellmigrationregulationofcellmigrationinvolvedinsproutingangiogenesisregulationofendothelialcellchemotaxistofibroblastgrowthfactorregulationofretinalcellprogrammedcelldeathreleaseofsequesteredcalciumionintocytosolresponsetoaxoninjurysignaltransductionstemcelldevelopmentstemcellproliferationsubstantianigradevelopmentthyroid-stimulatinghormone-secretingcelldifferentiationtranscriptionbyRNApolymeraseIIwoundhealing
Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7
47
Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7
47
2.0
82
0.59
JMJD7JMJD7P0C872P0C872proteinhydroxylationproteolysis
E3 SUMO-protein ligase RanBP2
3071
E3 SUMO-protein ligase RanBP2
3213
2.0
75
0.65
RBP2RBP2P49792P49792centrosomelocalizationmRNAtransportNLS-bearingproteinimportintonucleusnuclearexportnucleocytoplasmictransportpositiveregulationofglucokinaseactivityproteinfoldingproteinpeptidyl-prolylisomerizationproteinsumoylationregulationofgluconeogenesis
N-acetyltransferase ESCO1
757
N-acetyltransferase ESCO1
757
2.0
84
0.58
ESCO1ESCO1Q5FWF5Q5FWF5mitoticsisterchromatidcohesionpeptidyl-lysineacetylationpost-translationalproteinacetylationregulationofDNAreplication
Peroxiredoxin-1
83
Peroxiredoxin-1
83
2.1
84
0.58
PRDX1PRDX1Q63716Q63716cellpopulationproliferationcellredoxhomeostasiserythrocytehomeostasishydrogenperoxidecatabolicprocessleukocyteactivationnaturalkillercellactivationnaturalkillercellmediatedcytotoxicityregulationofNIK/NF-kappaBsignalingregulationofstress-activatedMAPKcascaderemovalofsuperoxideradicalsresponsetooxidativestressresponsetoreactiveoxygenspecies
Transmembrane protease serine 13
317
Transmembrane protease serine 13
434
2.1
80
0.61
TMPSDTMPSDQ9BYE2Q9BYE2proteolysis
Mucin-2
1088
Mucin-2
1088
2.1
82
0.59
MUC2MUC2Q02817Q02817maintenanceofgastrointestinalepithelium
Myeloid cell surface antigen CD33
36
Myeloid cell surface antigen CD33
36
2.1
72
0.67
CD33CD33P20138P20138celladhesioncell-celladhesioncell-cellsignalingimmuneresponse-inhibitingsignaltransductionnegativeregulationofcalciumiontransportnegativeregulationofcellpopulationproliferationnegativeregulationofinterleukin-1betaproductionnegativeregulationofinterleukin-8productionnegativeregulationofmonocyteactivationnegativeregulationoftumornecrosisfactorproductionpositiveregulationofproteinsecretionpositiveregulationofproteintyrosinephosphataseactivitysignaltransduction
Mitogen-activated protein kinase kinase kinase 9
421
Mitogen-activated protein kinase kinase kinase 9
421
2.1
60
0.81
M3K9M3K9P80192P80192apoptoticprocesspositiveregulationofapoptoticprocessproteinautophosphorylationproteinphosphorylation
Fibrinogen alpha chain
180
Fibrinogen beta chain
223
2.0
77
0.63
FIBAFIBBP02671P02675adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncelladhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulus
Chromobox protein homolog 3
69
Chromobox protein homolog 3
69
2.1
82
0.57
CBX3CBX3Q13185Q13185cellularresponsetoDNAdamagestimuluschromatinorganizationchromatinremodelingheterochromatinassemblynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionDNA-templatedrhythmicprocess
Isoform 2 of Potassium channel subfamily K member 4
78
Isoform 2 of Potassium channel subfamily K member 4
78
2.2
86
0.53
KCNK4KCNK4Q9NYG8-2Q9NYG8-2
Myosin-7
947
Myosin-7
947
2.1
52
0.91
MYH7MYH7P12883P12883adultheartdevelopmentATPmetabolicprocesscardiacmusclecontractioncardiacmusclehypertrophyinresponsetostressmusclecontractionmusclefilamentslidingregulationofheartrateregulationofslow-twitchskeletalmusclefibercontractionregulationoftheforceofheartcontractionregulationoftheforceofskeletalmusclecontractionsarcomereorganizationskeletalmusclecontractionstriatedmusclecontractiontransitionbetweenfastandslowfiberventricularcardiacmuscletissuemorphogenesis
Cadherin-23
863
Cadherin-23
863
2.1
92
0.53
CAD23CAD23Q99PF4Q99PF4auditoryreceptorcellstereociliumorganizationcalciumiontransportcalcium-dependentcell-celladhesionviaplasmamembranecelladhesionmoleculescelladhesioncell-celladhesionviaplasma-membraneadhesionmoleculesequilibrioceptionhomophiliccelladhesionviaplasmamembraneadhesionmoleculesinnerearauditoryreceptorcelldifferentiationinnereardevelopmentinnerearmorphogenesisinnerearreceptorcellstereociliumorganizationlocomotorybehaviorphotoreceptorcellmaintenancepost-embryonicanimalorganmorphogenesisregulationofcytosoliccalciumionconcentrationsensoryperceptionoflightstimulussensoryperceptionofsound
SH3 and multiple ankyrin repeat domains protein 3
41
SH3 and multiple ankyrin repeat domains protein 3
41
2.1
57
0.85
SHAN3SHAN3Q9BYB0Q9BYB0adultbehaviorAMPAglutamatereceptorclusteringbrainmorphogenesisdendriticspinemorphogenesisguanylatekinase-associatedproteinclusteringlearningMAPKcascadememorynegativeregulationofactinfilamentbundleassemblynegativeregulationofcellvolumeNMDAglutamatereceptorclusteringpositiveregulationofAMPAreceptoractivitypositiveregulationofdendriticspinedevelopmentpositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofglutamatereceptorsignalingpathwaypositiveregulationoflong-termneuronalsynapticplasticitypositiveregulationoflong-termsynapticpotentiationpositiveregulationofsynapsestructuralplasticitypositiveregulationofsynaptictransmissionglutamatergicpostsynapticdensityassemblyregulationofdendriticspinemorphogenesisregulationoflong-termsynapticdepressionregulationoflong-termsynapticpotentiationsocialbehaviorstriatalmediumspinyneurondifferentiationsynapseassemblyvocallearningvocalizationbehavior
Histone deacetylase complex subunit SAP18
26
Histone deacetylase complex subunit SAP18
26
2.1
41
1.18
SAP18SAP18O55128O55128mRNAprocessingnegativeregulationofmRNAsplicingviaspliceosomenegativeregulationoftranscriptionDNA-templatedpositiveregulationofapoptoticprocessregulationofalternativemRNAsplicingviaspliceosomeregulationoftranscriptionDNA-templatedRNAsplicing
PWWP domain-containing DNA repair factor 3A
501
PWWP domain-containing DNA repair factor 3A
501
2.1
46
1.05
PWP3APWP3AQ2TAK8Q2TAK8chromatinorganizationDNArepair
ADP-ribosylation factor GTPase-activating protein 1
96
ADP-ribosylation factor GTPase-activating protein 1
96
2.1
34
1.42
ARFG1ARFG1Q8N6T3Q8N6T3proteintransportregulationofARFproteinsignaltransductionregulationofendocytosisvesicle-mediatedtransport
Complement C5
704
Complement C5
704
2.1
67
0.72
CO5CO5P01031P01031cellsurfacereceptorsignalingpathwaychemotaxiscomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisGprotein-coupledreceptorsignalingpathwayinuteroembryonicdevelopmentinflammatoryresponsenegativeregulationofmacrophagechemotaxispositiveregulationofangiogenesispositiveregulationofchemokineproductionpositiveregulationofimmuneresponsepositiveregulationofvascularendothelialgrowthfactorproduction
Toll-like receptor 6
712
Toll-like receptor 6
712
2.1
74
0.65
TLR6TLR6Q9Y2C9Q9Y2C9activationofNF-kappaB-inducingkinaseactivitycellactivationcellularresponsetoamyloid-betacellularresponsetobacteriallipopeptidecellularresponsetodiacylbacteriallipopeptidecellularresponsetooxidisedlow-densitylipoproteinparticlestimulusdefenseresponsetobacteriumdetectionofdiacylbacteriallipopeptideimmuneresponseinflammatoryresponseinnateimmuneresponseMyD88-dependenttoll-likereceptorsignalingpathwaynegativeregulationofinterleukin-8productionnegativeregulationoftoll-likereceptor2signalingpathwaypositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJUNkinaseactivitypositiveregulationofmacrophageactivationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofNLRP3inflammasomecomplexassemblypositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofreactiveoxygenspeciesbiosyntheticprocesssignaltransductiontoll-likereceptor6signalingpathwaytoll-likereceptorsignalingpathwaytoll-likereceptorTLR6TRIF-dependenttoll-likereceptorsignalingpathway
Bromodomain adjacent to zinc finger domain protein 2B
827
Bromodomain adjacent to zinc finger domain protein 2B
827
2.1
75
0.64
BAZ2BBAZ2BQ9UIF8Q9UIF8chromatinremodelingregulationoftranscriptionbyRNApolymeraseII
DNA ligase 4
137
DNA ligase 4
137
2.1
73
0.66
DNLI4DNLI4P49917P49917cellcyclecelldivisioncellpopulationproliferationcellularresponsetoionizingradiationcellularresponsetolithiumioncentralnervoussystemdevelopmentchromosomeorganizationDN2thymocytedifferentiationDNAbiosyntheticprocessDNAligationDNAligationinvolvedinDNArecombinationDNAligationinvolvedinDNArepairDNAreplicationdouble-strandbreakrepairdouble-strandbreakrepairviaclassicalnonhomologousendjoiningdouble-strandbreakrepairvianonhomologousendjoiningestablishmentofintegratedprovirallatencyfibroblastproliferationimmunoglobulinV(D)Jrecombinationinuteroembryonicdevelopmentisotypeswitchingnegativeregulationofneuronapoptoticprocessneurogenesisneuronapoptoticprocessnucleotide-excisionrepairDNAgapfillingpositiveregulationofchromosomeorganizationpositiveregulationoffibroblastproliferationpositiveregulationofneurogenesispro-BcelldifferentiationresponsetogammaradiationresponsetoX-raysinglestrandbreakrepairsomaticstemcellpopulationmaintenancestemcellproliferationTcelldifferentiationinthymusTcellreceptorV(D)JrecombinationV(D)Jrecombination
Dynamin-3
676
Dynamin-3
676
2.1
69
0.69
DYN3DYN3Q9UQ16Q9UQ16endocytosisfilopodiumassemblynegativeregulationofdendriticspinemorphogenesispositiveregulationoffilopodiumassemblypositiveregulationofsynapticvesiclerecyclingpostsynapticneurotransmitterreceptorinternalizationreceptorinternalizationsynapseassemblysynapticvesicleendocytosis
Sorting nexin-32
49
Sorting nexin-32
49
2.1
54
0.88
SNX32SNX32Q86XE0Q86XE0proteintransportregulationofmacroautophagyretrogradetransportendosometoGolgi
Acrosin
160
Acrosin
26
2.1
81
0.59
ACROACROP08001P08001acrosomereactionactivationofadenylatecyclaseactivityproteolysissinglefertilization
Bifunctional peptidase and arginyl-hydroxylase JMJD5
232
Bifunctional peptidase and arginyl-hydroxylase JMJD5
232
2.0
65
0.75
KDM8KDM8Q8N371Q8N371chromatinorganizationcircadianregulationofgeneexpressionG2/MtransitionofmitoticcellcyclehistoneH3-K36demethylationnegativeregulationoftranscriptionDNA-templatedpositiveregulationoftranscriptionDNA-templatedproteindestabilizationproteolysis
Transforming acidic coiled-coil-containing protein 3
621
Transforming acidic coiled-coil-containing protein 3
621
2.0
72
0.68
TACC3TACC3Q9JJ11Q9JJ11astralmicrotubuleorganizationcelldivisioncellpopulationproliferationcerebralcortexdevelopmentcytoplasmicsequesteringoftranscriptionfactorhemopoiesisinterkineticnuclearmigrationmetaphase/anaphasetransitionofmitoticcellcyclemicrotubulecytoskeletonorganizationmicrotubulecytoskeletonorganizationinvolvedinmitosismitoticspindleorganizationneurogenesisregulationofcellcycleregulationofmicrotubule-basedprocessregulationofmitoticspindleorganizationresponsetohypoxiastemcellproliferation
Abasic site processing protein HMCES
39
Abasic site processing protein HMCES
39
2.1
72
0.67
HMCESHMCESQ96FZ2Q96FZ2cellularresponsetoDNAdamagestimulusdouble-strandbreakrepairviaalternativenonhomologousendjoiningpositiveregulationofisotypeswitchingprotein-DNAcovalentcross-linkingproteolysis
Oxidized purine nucleoside triphosphate hydrolase
134
Oxidized purine nucleoside triphosphate hydrolase
134
2.0
89
0.55
8ODP8ODPP53368P53368agingDNAprotectionmalegonaddevelopmentpurinenucleosidecatabolicprocessresponsetocadmiumion
TP53-binding protein 1
1525
TP53-binding protein 1
1525
2.1
87
0.54
TP53BTP53BQ12888Q12888cellularresponsetoDNAdamagestimuluscellularresponsetoX-rayDNAdamagecheckpointsignalingdouble-strandbreakrepairvianonhomologousendjoiningnegativeregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofisotypeswitchingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedproteinhomooligomerization
Plexin-C1
1227
Plexin-C1
1227
2.1
74
0.65
PLXC1PLXC1O60486O60486celladhesionnegativeregulationofcelladhesionpositiveregulationofaxonogenesisregulationofcellmigrationregulationofcellshaperegulationofGTPaseactivitysemaphorin-plexinsignalingpathwayinvolvedinaxonguidance
Replication protein A 32 kDa subunit
219
Replication protein A 32 kDa subunit
219
2.1
76
0.61
RFA2RFA2P15927P15927base-excisionrepairDNAreplicationdouble-strandbreakrepairviahomologousrecombinationmismatchrepairmitoticG1DNAdamagecheckpointsignalingnucleotide-excisionrepairproteinlocalizationtochromosomeregulationofDNAdamagecheckpointregulationofdouble-strandbreakrepairviahomologousrecombinationtelomeremaintenance
Tropomyosin alpha-1 chain
190
Tropomyosin alpha-1 chain
190
2.2
54
0.86
1
✔TPM1TPM1P04692P04692actinfilamentcappingactinfilamentorganizationcardiacmusclecontractioncellularresponsetoreactiveoxygenspeciesinuteroembryonicdevelopmentmusclecontractionmusclefilamentslidingnegativeregulationofcellmigrationnegativeregulationofvascularassociatedsmoothmusclecellmigrationnegativeregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofATP-dependentactivitypositiveregulationofcelladhesionpositiveregulationofheartratebyepinephrinepositiveregulationofstressfiberassemblyregulationofATP-dependentactivityregulationofcellshaperuffleorganizationsarcomereorganizationventricularcardiacmuscletissuemorphogenesiswoundhealing
Tripartite motif-containing protein 67
702
Tripartite motif-containing protein 67
702
2.2
71
0.65
TRI67TRI67Q6ZTA4Q6ZTA4negativeregulationofRasproteinsignaltransductionpositiveregulationofneuronprojectiondevelopmentpositiveregulationofubiquitin-dependentproteincatabolicprocessregulationofproteinlocalization
Ketohexokinase
98
Ketohexokinase
98
2.1
90
0.53
KHKKHKP50053P50053fructosemetabolicprocessregulationofglycogenmetabolicprocessresponsetofructoseresponsetoglucoseresponsetoinsulinresponsetosucroseresponsetozincion
Alpha-crystallin B chain
nan
Alpha-crystallin B chain
nan
2.0
59
0.83
CRYABCRYABP02511P02511apoptoticprocessinvolvedinmorphogenesiscellularresponsetogammaradiationlensdevelopmentincamera-typeeyemicrotubulepolymerizationordepolymerizationmulticellularorganismagingmusclecontractionmuscleorgandevelopmentnegativeregulationofamyloidfibrilformationnegativeregulationofapoptoticprocessnegativeregulationofcellgrowthnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofintracellulartransportnegativeregulationofprotein-containingcomplexassemblynegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationoftranscriptionDNA-templatedproteinfoldingproteinrefoldingproteinstabilizationregulationofcelldeathresponsetoestradiolresponsetoheatresponsetohydrogenperoxideresponsetohypoxiastress-activatedMAPKcascadetubulincomplexassembly
ETS domain-containing transcription factor ERF
72
ETS domain-containing transcription factor ERF
72
2.0
38
1.3
ERFERFP50548P50548celldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Immunoglobulin lambda constant 1
105
Immunoglobulin lambda constant 1
105
2.0
29
1.7
IGLC1IGLC1P01842P01842adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Filamin-A
59
Filamin-A
59
2.0
44
1.12
FLNAFLNAP21333P21333actincrosslinkformationactincytoskeletonreorganizationadenylatecyclase-inhibitingdopaminereceptorsignalingpathwayangiogenesisbloodcoagulationintrinsicpathwaybloodvesselremodelingcell-celljunctionorganizationciliumassemblycytoplasmicsequesteringofproteinearlyendosometolateendosometransportepithelialtomesenchymaltransitionestablishmentofproteinlocalizationheartmorphogenesismegakaryocytedevelopmentmitoticspindleassemblynegativeregulationofapoptoticprocessnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofneuronprojectiondevelopmentnegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIplateletaggregationpositiveregulationofaxonregenerationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofintegrin-mediatedsignalingpathwaypositiveregulationofplateletactivationpositiveregulationofpotassiumiontransmembranetransportpositiveregulationofproteinimportintonucleuspositiveregulationofsubstrateadhesion-dependentcellspreadingproteinlocalizationtocellsurfaceproteinlocalizationtoplasmamembraneproteinstabilizationreceptorclusteringregulationofactinfilamentbundleassemblyregulationofcellmigrationregulationofmembranerepolarizationduringatrialcardiacmusclecellactionpotentialregulationofmembranerepolarizationduringcardiacmusclecellactionpotentialreleaseofsequesteredcalciumionintocytosolsemaphorin-plexinsignalingpathwaysynapseorganizationtubulindeacetylationwoundhealingspreadingofcells
Tumor necrosis factor receptor superfamily member 16
379
Tumor necrosis factor receptor superfamily member 16
379
2.0
86
0.58
TNR16TNR16P07174P07174activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessaxonguidancecellularglucosehomeostasiscellularresponsetoamyloid-betacellularresponsetooxidativestresscentralnervoussystemdevelopmentcircadianregulationofgeneexpressioncircadianrhythmdetectionoftemperaturestimulusdorsalaortadevelopmentglucosehomeostasishairfolliclemorphogenesisintracellularproteintransportnegativeregulationofangiogenesisnegativeregulationofapoptoticprocessnegativeregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisnegativeregulationofcellmigrationnegativeregulationofdendriticspinedevelopmentnegativeregulationoffibroblastgrowthfactorreceptorsignalingpathwaynegativeregulationofhairfollicledevelopmentnegativeregulationofmitochondrialdepolarizationnegativeregulationofneuronapoptoticprocessnegativeregulationofneuronprojectiondevelopmentnervedevelopmentneuronapoptoticprocesspositiveregulationofapoptoticprocesspositiveregulationofapoptoticsignalingpathwaypositiveregulationofexcitatorypostsynapticpotentialpositiveregulationoffibroblastproliferationpositiveregulationofMAPKcascadepositiveregulationofmiRNAtranscriptionpositiveregulationofmyelinationpositiveregulationofneuralprecursorcellproliferationpositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofodontogenesisofdentin-containingtoothpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofRhoproteinsignaltransductionpositiveregulationofsynaptictransmissioncholinergicpositiveregulationofsynaptictransmissionglutamatergicregulationofcelldeathregulationofgeneexpressionregulationofreactiveoxygenspeciesmetabolicprocessresponsetolipopolysaccharideresponsetowoundingRhoproteinsignaltransductionsensoryperceptionofpainsignaltransductionskeletalmusclecelldifferentiationskindevelopment
Growth factor receptor-bound protein 7
526
Growth factor receptor-bound protein 7
527
2.0
79
0.63
GRB7GRB7Q14451Q14451epidermalgrowthfactorreceptorsignalingpathwaynegativeregulationoftranslationpositiveregulationofcellmigrationstressgranuleassembly
Cardiac phospholamban
41
Cardiac phospholamban
36
2.7
60
0.63
PPLAPPLAP61015P61015adenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocesscardiacmuscletissuedevelopmentcellularcalciumionhomeostasismusclecellcellularhomeostasisnegativeregulationofATPase-coupledcalciumtransmembranetransporteractivitynegativeregulationofcalciumionbindingnegativeregulationofcalciumionimportnegativeregulationofcalciumionimportintosarcoplasmicreticulumnegativeregulationofcalciumiontransmembranetransporteractivitynegativeregulationofcatalyticactivitynegativeregulationofheartrateNotchsignalingpathwayregulationofcalciumiontransportregulationofcardiacmusclecellcontractionregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofrelaxationofmuscleregulationofryanodine-sensitivecalcium-releasechannelactivityregulationoftheforceofheartcontractionbycardiacconduction
Insulin-like 3
129
Insulin-like 3
46
2.0
52
0.95
INSL3INSL3P51460P51460adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaycell-cellsignalingmalegonaddevelopmentnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationoocytematurationpositiveregulationofcAMP-mediatedsignalingpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofwoundhealingspermatogenesis
Insulin
96
Insulin
31
2.0
nan
nan
INSINSQ5EEX2Q5EEX2activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
Cardiac phospholamban
41
Cardiac phospholamban
36
2.0
64
0.77
PPLAPPLAP26678P26678adenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocessbloodcirculationcardiacmuscletissuedevelopmentmusclecellcellularhomeostasisnegativeregulationofATP-dependentactivitynegativeregulationofATPase-coupledcalciumtransmembranetransporteractivitynegativeregulationofcalciumionbindingnegativeregulationofcalciumionimportnegativeregulationofcalciumionimportintosarcoplasmicreticulumnegativeregulationofcalciumiontransmembranetransporteractivitynegativeregulationofcalciumiontransportnegativeregulationofcatalyticactivitynegativeregulationofheartrateNotchsignalingpathwayregulationofATPase-coupledcalciumtransmembranetransporteractivityregulationofcalciumiontransportregulationofcardiacmusclecellcontractionregulationofcardiacmusclecellmembranepotentialregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofcytosoliccalciumionconcentrationregulationofheartcontractionregulationofrelaxationofcardiacmuscleregulationofryanodine-sensitivecalcium-releasechannelactivityregulationoftheforceofheartcontractionregulationoftheforceofheartcontractionbycardiacconductionrelaxationofcardiacmuscle
Defensin alpha 5
82
Defensin alpha 5
67
2.0
67
0.73
DEF5DEF5Q01523Q01523antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellskillingofcellsofanotherorganismmembranedisruptioninanotherorganismpositiveregulationofinterleukin-8productionpositiveregulationofmembranepermeabilityproteinhomotetramerization
Insulin
95
Insulin
31
2.0
42
1.18
INSINSP01308P01308activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
Tumor necrosis factor receptor superfamily member 16
256
Tumor necrosis factor receptor superfamily member 16
256
2.0
49
1.01
TNR16TNR16P08138P08138activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessaxonguidancecellularglucosehomeostasiscellularresponsetoamyloid-betacentralnervoussystemdevelopmentcircadianregulationofgeneexpressiondetectionoftemperaturestimulusdorsalaortadevelopmentfibroblastgrowthfactorreceptorsignalingpathwayfibroblastproliferationglucosehomeostasishairfolliclemorphogenesisintracellularproteintransportnegativeregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisnegativeregulationofcellmigrationnegativeregulationoffibroblastgrowthfactorreceptorsignalingpathwaynegativeregulationofhairfollicledevelopmentnervedevelopmentneuronapoptoticprocessodontogenesisofdentin-containingtoothpositiveregulationofapoptoticsignalingpathwaypositiveregulationoffibroblastproliferationpositiveregulationofmiRNAtranscriptionpositiveregulationofodontogenesisofdentin-containingtoothpositiveregulationofproteinlocalizationtonucleusRhoproteinsignaltransduction
Coagulation factor XI
339
Coagulation factor XI
339
2.0
100
0.49
FA11FA11P03951P03951bloodcoagulationbloodcoagulationintrinsicpathwayplasminogenactivationpositiveregulationoffibrinolysisproteolysiszymogenactivation
Thioredoxin
32
DNA-(apurinic or apyrimidinic site) endonuclease
65
2.0
59
0.84
THIOAPEX1P10599P27695activationofproteinkinaseBactivitycellredoxhomeostasisnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiationagingbase-excisionrepairbase-excisionrepairgap-fillingcellularresponsetocAMPcellularresponsetohydrogenperoxidecellularresponsetopeptidehormonestimulusDNAcatabolicprocessendonucleolyticDNAdemethylationDNArecombinationDNArepairnegativeregulationofsmoothmusclecellmigrationpositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofapoptoticprocessregulationofmRNAstabilityresponsetoxenobioticstimulustelomeremaintenancetelomeremaintenanceviabase-excisionrepair
Thioredoxin
32
Nuclear factor NF-kappa-B p105 subunit
61
2.0
61
0.81
THIONFKB1P10599P19838activationofproteinkinaseBactivitycellredoxhomeostasisnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiationapoptoticprocesscellularresponsetoangiotensincellularresponsetodsRNAcellularresponsetointerleukin-1cellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetomechanicalstimuluscellularresponsetonicotinecellularresponsetotumornecrosisfactorcellularresponsetovirusinflammatoryresponseJNKcascademammaryglandinvolutionnegativeregulationofapoptoticprocessnegativeregulationofcalcidiol1-monooxygenaseactivitynegativeregulationofcholesteroltransportnegativeregulationofgeneexpressionnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-12productionnegativeregulationofproteinmetabolicprocessnegativeregulationofvitaminDbiosyntheticprocesspositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofhyaluronanbiosyntheticprocesspositiveregulationoflipidstoragepositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofmiRNAmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedregulationoftranscriptionbyRNApolymeraseIIresponsetomusclestretchtranscriptionbyRNApolymeraseII
Insulin-like 3
116
Insulin-like 3
34
2.0
45
1.09
INSL3INSL3P51460P51460adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaycell-cellsignalingmalegonaddevelopmentnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationoocytematurationpositiveregulationofcAMP-mediatedsignalingpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofwoundhealingspermatogenesis
Trefoil factor 3
78
Trefoil factor 3
78
1.8
82
0.66
TFF3TFF3Q07654Q07654maintenanceofgastrointestinalepitheliumregulationofglucosemetabolicprocess
Integrin alpha-IIb
963
Integrin beta-3
630
2.0
40
1.24
ITA2BITB3P08514P05106angiogenesiscelladhesionmediatedbyintegrincell-celladhesioncell-matrixadhesionintegrin-mediatedsignalingpathwayactivationofproteinkinaseactivityangiogenesisinvolvedinwoundhealingapolipoproteinA-I-mediatedsignalingpathwayapoptoticcellclearancebloodcoagulationcelladhesioncellmigrationcell-substrateadhesioncell-substratejunctionassemblycellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetomechanicalstimuluscellularresponsetoplatelet-derivedgrowthfactorstimuluscellularresponsetoxenobioticstimulusembryoimplantationheterotypiccell-celladhesionmesodermalcelldifferentiationnegativechemotaxisnegativeregulationofcelldeathnegativeregulationoflipidstoragenegativeregulationoflipidtransportnegativeregulationoflipoproteinmetabolicprocessnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofmacrophagederivedfoamcelldifferentiationplateletactivationplateletaggregationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofadenylatecyclase-inhibitingopioidreceptorsignalingpathwaypositiveregulationofangiogenesispositiveregulationofboneresorptionpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofosteoblastproliferationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofTcellmigrationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofactincytoskeletonorganizationregulationofboneresorptionregulationofextracellularmatrixorganizationregulationofpostsynapticneurotransmitterreceptorinternalizationregulationofproteinlocalizationregulationofproteintyrosinekinaseactivityregulationofreleaseofsequesteredcalciumionintocytosolregulationofserotoninuptakeregulationoftrophoblastcellmigrationresponsetoactivityresponsetoradiationsmoothmusclecellmigrationsubstrateadhesion-dependentcellspreadingtubedevelopmentviralentryintohostcellwoundhealing
SAM and SH3 domain-containing protein 3
68
SAM and SH3 domain-containing protein 3
68
2.0
28
1.76
SASH3SASH3Q8K352Q8K352BcellhomeostasisBcellproliferationCD4-positivealpha-betaTcelldifferentiationhomeostasisofnumberofcellswithinatissuepositiveregulationofadaptiveimmuneresponsepositiveregulationofBcellproliferationpositiveregulationofCD4-positivealpha-betaTcelldifferentiationpositiveregulationofimmunoglobulinproductionpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationoflymphocyteactivationpositiveregulationoforgangrowthpositiveregulationofTcellcytokineproductionpositiveregulationofTcellproliferationpositiveregulationoftumornecrosisfactorproductionTcellproliferation
Defensin alpha-like protein 1
75
Defensin alpha-like protein 1
67
2.0
70
0.71
DFAL1DFAL1Q4JEI2Q4JEI2antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosamembranedisruptioninanotherorganism
Integrin alpha-IIb
962
Integrin beta-3
488
2.0
42
1.18
ITA2BITB3P08514P05106angiogenesiscelladhesionmediatedbyintegrincell-celladhesioncell-matrixadhesionintegrin-mediatedsignalingpathwayactivationofproteinkinaseactivityangiogenesisinvolvedinwoundhealingapolipoproteinA-I-mediatedsignalingpathwayapoptoticcellclearancebloodcoagulationcelladhesioncellmigrationcell-substrateadhesioncell-substratejunctionassemblycellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetomechanicalstimuluscellularresponsetoplatelet-derivedgrowthfactorstimuluscellularresponsetoxenobioticstimulusembryoimplantationheterotypiccell-celladhesionmesodermalcelldifferentiationnegativechemotaxisnegativeregulationofcelldeathnegativeregulationoflipidstoragenegativeregulationoflipidtransportnegativeregulationoflipoproteinmetabolicprocessnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofmacrophagederivedfoamcelldifferentiationplateletactivationplateletaggregationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofadenylatecyclase-inhibitingopioidreceptorsignalingpathwaypositiveregulationofangiogenesispositiveregulationofboneresorptionpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofosteoblastproliferationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofTcellmigrationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofactincytoskeletonorganizationregulationofboneresorptionregulationofextracellularmatrixorganizationregulationofpostsynapticneurotransmitterreceptorinternalizationregulationofproteinlocalizationregulationofproteintyrosinekinaseactivityregulationofreleaseofsequesteredcalciumionintocytosolregulationofserotoninuptakeregulationoftrophoblastcellmigrationresponsetoactivityresponsetoradiationsmoothmusclecellmigrationsubstrateadhesion-dependentcellspreadingtubedevelopmentviralentryintohostcellwoundhealing
Defensin alpha-like protein 1
65
Defensin alpha-like protein 1
77
2.0
72
0.69
DFAL1DFAL1Q4JEI2Q4JEI2antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosamembranedisruptioninanotherorganism
Stromal cell-derived factor 1
36
Stromal cell-derived factor 1
265
2.0
72
0.69
SDF1SDF1P48061P48061adultlocomotorybehavioranimalorganregenerationantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideaxonguidancebloodcirculationcelladhesioncellchemotaxiscellularcalciumionhomeostasiscellularresponsetochemokinechemokine(C-X-Cmotif)ligand12signalingpathwaychemokine-mediatedsignalingpathwaychemotaxisdefenseresponsedetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainGprotein-coupledreceptorsignalingpathwayimmuneresponseinductionofpositivechemotaxisintegrinactivationkillingofcellsofanotherorganismnegativeregulationofdendriticcellapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofleukocytetetheringorrollingneuronmigrationpositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofcalciumionimportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofdopaminesecretionpositiveregulationofendothelialcellproliferationpositiveregulationofmonocytechemotaxispositiveregulationofneurondifferentiationpositiveregulationofTcellmigrationregulationofactinpolymerizationordepolymerizationresponsetoheatresponsetohypoxiaresponsetopeptidehormoneresponsetoradiationresponsetoultrasoundresponsetovirussignaltransductionTcellchemotaxistelencephaloncellmigration
Stromal cell-derived factor 1
65
Stromal cell-derived factor 1
236
2.0
75
0.66
SDF1SDF1P48061P48061adultlocomotorybehavioranimalorganregenerationantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideaxonguidancebloodcirculationcelladhesioncellchemotaxiscellularcalciumionhomeostasiscellularresponsetochemokinechemokine(C-X-Cmotif)ligand12signalingpathwaychemokine-mediatedsignalingpathwaychemotaxisdefenseresponsedetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainGprotein-coupledreceptorsignalingpathwayimmuneresponseinductionofpositivechemotaxisintegrinactivationkillingofcellsofanotherorganismnegativeregulationofdendriticcellapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofleukocytetetheringorrollingneuronmigrationpositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofcalciumionimportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofdopaminesecretionpositiveregulationofendothelialcellproliferationpositiveregulationofmonocytechemotaxispositiveregulationofneurondifferentiationpositiveregulationofTcellmigrationregulationofactinpolymerizationordepolymerizationresponsetoheatresponsetohypoxiaresponsetopeptidehormoneresponsetoradiationresponsetoultrasoundresponsetovirussignaltransductionTcellchemotaxistelencephaloncellmigration
Transcription factor Jun
273
Transcription factor Jun
273
2.0
nan
nan
JUNJUNP05412P05412angiogenesisapoptoticprocessaxonregenerationcellpopulationproliferationcellularresponsetoanisomycincellularresponsetocadmiumioncellularresponsetocalciumioncellularresponsetoreactiveoxygenspecieseyeliddevelopmentincamera-typeeyeintegratedstressresponsesignalingleadingedgecelldifferentiationliverdevelopmentmicroglialcellactivationmonocytedifferentiationnegativeregulationbyhostofviraltranscriptionnegativeregulationofcellpopulationproliferationnegativeregulationofDNAbindingnegativeregulationofneuronapoptoticprocessnegativeregulationofproteinautophosphorylationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoendoplasmicreticulumstressnegativeregulationoftranscriptionDNA-templatedoutflowtractmorphogenesispositiveregulationbyhostofviraltranscriptionpositiveregulationofapoptoticprocesspositiveregulationofDNA-templatedtranscriptioninitiationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofmiRNAtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimuluspositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularassociatedsmoothmusclecellproliferationRasproteinsignaltransductionregulationofcellcycleregulationofcellpopulationproliferationregulationoftranscriptionbyRNApolymeraseIIresponsetomusclestretchresponsetoxenobioticstimulusSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Relaxin-3
35
Insulin-like peptide INSL5
122
2.0
43
1.15
REL3INSL5Q8WXF3Q9Y5Q6positiveregulationoffeedingbehavior
Relaxin-3
47
Relaxin-3
142
2.0
nan
nan
REL3REL3Q8WXF3Q8WXF3
TYRO protein tyrosine kinase-binding protein
35
TYRO protein tyrosine kinase-binding protein
35
2.0
nan
nan
TYOBPTYOBPO43914O43914actincytoskeletonorganizationapoptoticcellclearanceapoptoticsignalingpathwaycellulardefenseresponseforebraindevelopmentintracellularsignaltransductionmicroglialcellactivationinvolvedinimmuneresponsemyeloidleukocyteactivationnegativeregulationofBcellproliferationnegativeregulationofinterleukin-10productionnegativeregulationoflong-termsynapticpotentiationnegativeregulationoftransforminggrowthfactorbeta1productionneutrophilactivationinvolvedinimmuneresponseosteoclastdifferentiationpositiveregulationofgeneexpressionpositiveregulationofhippocampalneuronapoptoticprocesspositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofmacrophagefusionpositiveregulationofmicroglialcellmediatedcytotoxicitypositiveregulationofnaturalkillercellactivationpositiveregulationofneurondeathpositiveregulationofosteoclastdevelopmentpositiveregulationofproteinlocalizationtocellsurfacepositiveregulationofreceptorlocalizationtosynapsepositiveregulationofsuperoxideaniongenerationpositiveregulationoftumornecrosisfactorproductionproteinstabilizationresponsetoaxoninjurysignaltransductionstimulatoryC-typelectinreceptorsignalingpathwaystimulatorykillercellimmunoglobulin-likereceptorsignalingpathway
Defensin alpha-like protein 1
71
Defensin alpha-like protein 1
71
2.0
28
1.77
DFAL1DFAL1Q4JEI2Q4JEI2antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosamembranedisruptioninanotherorganism
Tropomyosin alpha-1 chain
249
Tropomyosin alpha-1 chain
249
2.0
37
1.33
1
✔TPM1TPM1P04692P04692actinfilamentcappingactinfilamentorganizationcardiacmusclecontractioncellularresponsetoreactiveoxygenspeciesinuteroembryonicdevelopmentmusclecontractionmusclefilamentslidingnegativeregulationofcellmigrationnegativeregulationofvascularassociatedsmoothmusclecellmigrationnegativeregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofATP-dependentactivitypositiveregulationofcelladhesionpositiveregulationofheartratebyepinephrinepositiveregulationofstressfiberassemblyregulationofATP-dependentactivityregulationofcellshaperuffleorganizationsarcomereorganizationventricularcardiacmuscletissuemorphogenesiswoundhealing
Transmembrane emp24 domain-containing protein 10
1
Transmembrane emp24 domain-containing protein 10
1
2.0
nan
nan
TMEDATMEDAQ28735Q28735COPI-coatedvesiclebuddingcytosoltoERGICproteintransportpositiveregulationofinterleukin-1productionpositiveregulationofproteinsecretionproteinlocalizationtoERGICregulationofamyloid-betaformationretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulum
Myc proto-oncogene protein
3
Protein max
nan
2.0
nan
nan
MYCMAXP01106P28574branchinginvolvedinuretericbudmorphogenesiscellularironionhomeostasiscellularresponsetoDNAdamagestimuluscellularresponsetohypoxiacellularresponsetoUVcellularresponsetoxenobioticstimuluschromatinremodelingchromosomeorganizationenergyreservemetabolicprocessERK1andERK2cascadefibroblastapoptoticprocessG1/StransitionofmitoticcellcycleMAPKcascadenegativeregulationofapoptoticprocessnegativeregulationofcelldivisionnegativeregulationoffibroblastproliferationnegativeregulationofmonocytedifferentiationnegativeregulationofstress-activatedMAPKcascadenegativeregulationoftranscriptionbyRNApolymeraseIIoxygentransportpositiveregulationofcellpopulationproliferationpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofDNAbiosyntheticprocesspositiveregulationofDNAmethylationpositiveregulationofepithelialcellproliferationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofmesenchymalcellproliferationpositiveregulationofmetanephriccapmesenchymalcellproliferationpositiveregulationofmiRNAtranscriptionpositiveregulationofresponsetoDNAdamagestimuluspositiveregulationoftelomeraseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprotein-DNAcomplexdisassemblyregulationofcellcycleprocessregulationofgeneexpressionregulationofsomaticstemcellpopulationmaintenanceregulationoftelomeremaintenanceregulationoftranscriptionbyRNApolymeraseIIresponsetogammaradiationresponsetogrowthfactorresponsetoxenobioticstimuluscellularresponsetopeptidehormonestimuluscellularresponsetostarvationnegativeregulationofgeneexpressionneuronapoptoticprocessprotein-containingcomplexassemblyregulationoftranscriptionDNA-templatedresponsetoaxoninjuryresponsetoinsulinretinadevelopmentincamera-typeeye
Relaxin-3
47
Insulin-like peptide INSL5
135
2.0
nan
nan
REL3INSL5Q8WXF3Q9Y5Q6positiveregulationoffeedingbehavior
Insulin
109
Insulin
43
2.0
50
0.99
INSINSQ5EEX2Q5EEX2activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealing
55 kDa erythrocyte membrane protein
85
Glycophorin-C
nan
2.0
61
0.81
EM55GLPCQ00013P04921regulationofneutrophilchemotaxissignaltransduction
Protein max
nan
Protein max
nan
2.0
nan
nan
MAXMAXP61244P61244cellularresponsetopeptidehormonestimuluscellularresponsetostarvationnegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIIneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionDNA-templatedprotein-containingcomplexassemblyregulationoftranscriptionbyRNApolymeraseIIresponsetoaxoninjuryresponsetoinsulinretinadevelopmentincamera-typeeye
Tumor necrosis factor receptor superfamily member 16
257
Tumor necrosis factor receptor superfamily member 16
257
1.9
48
1.1
TNR16TNR16P07174P07174activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessaxonguidancecellularglucosehomeostasiscellularresponsetoamyloid-betacellularresponsetooxidativestresscentralnervoussystemdevelopmentcircadianregulationofgeneexpressioncircadianrhythmdetectionoftemperaturestimulusdorsalaortadevelopmentglucosehomeostasishairfolliclemorphogenesisintracellularproteintransportnegativeregulationofangiogenesisnegativeregulationofapoptoticprocessnegativeregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisnegativeregulationofcellmigrationnegativeregulationofdendriticspinedevelopmentnegativeregulationoffibroblastgrowthfactorreceptorsignalingpathwaynegativeregulationofhairfollicledevelopmentnegativeregulationofmitochondrialdepolarizationnegativeregulationofneuronapoptoticprocessnegativeregulationofneuronprojectiondevelopmentnervedevelopmentneuronapoptoticprocesspositiveregulationofapoptoticprocesspositiveregulationofapoptoticsignalingpathwaypositiveregulationofexcitatorypostsynapticpotentialpositiveregulationoffibroblastproliferationpositiveregulationofMAPKcascadepositiveregulationofmiRNAtranscriptionpositiveregulationofmyelinationpositiveregulationofneuralprecursorcellproliferationpositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofodontogenesisofdentin-containingtoothpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofRhoproteinsignaltransductionpositiveregulationofsynaptictransmissioncholinergicpositiveregulationofsynaptictransmissionglutamatergicregulationofcelldeathregulationofgeneexpressionregulationofreactiveoxygenspeciesmetabolicprocessresponsetolipopolysaccharideresponsetowoundingRhoproteinsignaltransductionsensoryperceptionofpainsignaltransductionskeletalmusclecelldifferentiationskindevelopment
Copper-transporting ATPase 1
19
Copper transport protein ATOX1
12
2.0
48
1.06
ATP7AATOX1Q04656O00244bloodvesseldevelopmentbloodvesselremodelingcartilagedevelopmentcatecholaminemetabolicprocesscellularcopperionhomeostasiscellularresponsetoaminoacidstimuluscellularresponsetoantibioticcellularresponsetocadmiumioncellularresponsetocobaltioncellularresponsetocopperioncellularresponsetohypoxiacellularresponsetoironioncellularresponsetoleadioncellularresponsetoplatelet-derivedgrowthfactorstimuluscentralnervoussystemneurondevelopmentcerebellarPurkinjecelldifferentiationcollagenfibrilorganizationcopperionexportcopperionhomeostasiscopperionimportcopperiontransportdetoxificationofcopperiondopaminemetabolicprocesselasticfiberassemblyelastinbiosyntheticprocessepinephrinemetabolicprocessextracellularmatrixorganizationfemalepregnancyhairfolliclemorphogenesisinuteroembryonicdevelopmentlactationliverdevelopmentlocomotorybehaviorlungalveolusdevelopmentmitochondrionorganizationnegativeregulationofironiontransmembranetransportneuronprojectionmorphogenesisnorepinephrinemetabolicprocesspeptidyl-lysinemodificationpigmentationpositiveregulationofcatalyticactivitypositiveregulationofcellsizepositiveregulationofepithelialcellproliferationpositiveregulationoflamellipodiumassemblypositiveregulationofmelaninbiosyntheticprocesspositiveregulationofresponsetowoundingpositiveregulationoftyrosinaseactivitypositiveregulationofvascularassociatedsmoothmusclecellmigrationpyramidalneurondevelopmentregulationofcytochrome-coxidaseactivityregulationofgeneexpressionregulationofoxidativephosphorylationremovalofsuperoxideradicalsresponsetoiron(III)ionresponsetomanganeseionresponsetozincionserotoninmetabolicprocessskindevelopmentT-helpercelldifferentiationtryptophanmetabolicprocessresponsetooxidativestress
T-cell surface glycoprotein CD3 zeta chain
32
T-cell surface glycoprotein CD3 zeta chain
32
2.0
40
1.24
CD3ZCD3ZP20963P20963adaptiveimmuneresponsealpha-betaTcellactivationcellsurfacereceptorsignalingpathwayFc-gammareceptorsignalingpathwaygamma-deltaTcellactivationpositiveregulationofproteinlocalizationtocellsurfaceprotein-containingcomplexassemblyTcellreceptorsignalingpathway
Relaxin-3
35
Relaxin-3
129
2.0
50
0.99
REL3REL3Q8WXF3Q8WXF3
Defensin alpha-like protein 1
65
Defensin alpha-like protein 1
65
3.0
70
0.48
DFAL1DFAL1Q4JEI2Q4JEI2antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosamembranedisruptioninanotherorganism
C-C motif chemokine 3
57
C-C motif chemokine 3
57
3.0
54
0.62
CCL3CCL3P10147P10147astrocytecellmigrationcalciumiontransportcalcium-mediatedsignalingcellactivationcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytoskeletonorganizationeosinophilchemotaxiseosinophildegranulationexocytosisGprotein-coupledreceptorsignalingpathwaygranulocytechemotaxisinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofosteoclastdifferentiationneutrophilchemotaxisosteoblastdifferentiationpositiveregulationofcalciumionimportpositiveregulationofcalciumiontransportpositiveregulationofcalcium-mediatedsignalingpositiveregulationofcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofmicroglialcellactivationpositiveregulationofmicroglialcellmigrationpositiveregulationofnaturalkillercellchemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofproteinkinaseBsignalingpositiveregulationoftumornecrosisfactorproductionproteinkinaseBsignalingregulationofbehaviorregulationofcellshaperegulationofsensoryperceptionofpainreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolresponsetotoxicsubstancesignalingTcellchemotaxis
C-C motif chemokine 3
57
C-C motif chemokine 3
33
3.0
68
0.5
CCL3CCL3P10147P10147astrocytecellmigrationcalciumiontransportcalcium-mediatedsignalingcellactivationcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytoskeletonorganizationeosinophilchemotaxiseosinophildegranulationexocytosisGprotein-coupledreceptorsignalingpathwaygranulocytechemotaxisinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofosteoclastdifferentiationneutrophilchemotaxisosteoblastdifferentiationpositiveregulationofcalciumionimportpositiveregulationofcalciumiontransportpositiveregulationofcalcium-mediatedsignalingpositiveregulationofcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofmicroglialcellactivationpositiveregulationofmicroglialcellmigrationpositiveregulationofnaturalkillercellchemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofproteinkinaseBsignalingpositiveregulationoftumornecrosisfactorproductionproteinkinaseBsignalingregulationofbehaviorregulationofcellshaperegulationofsensoryperceptionofpainreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolresponsetotoxicsubstancesignalingTcellchemotaxis
Trefoil factor 1
82
Trefoil factor 1
82
2.0
27
1.82
TFF1TFF1P04155P04155carbohydratemetabolicprocesscelldifferentiationcellpopulationproliferationmaintenanceofgastrointestinalepitheliumnegativeregulationofcellpopulationproliferationresponsetoimmobilizationstressresponsetoironionresponsetopeptidehormone
C-C motif chemokine 3
33
C-C motif chemokine 3
33
2.7
82
0.45
CCL3CCL3P10147P10147astrocytecellmigrationcalciumiontransportcalcium-mediatedsignalingcellactivationcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerferon-gammacellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxiscytoskeletonorganizationeosinophilchemotaxiseosinophildegranulationexocytosisGprotein-coupledreceptorsignalingpathwaygranulocytechemotaxisinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofosteoclastdifferentiationneutrophilchemotaxisosteoblastdifferentiationpositiveregulationofcalciumionimportpositiveregulationofcalciumiontransportpositiveregulationofcalcium-mediatedsignalingpositiveregulationofcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofmicroglialcellactivationpositiveregulationofmicroglialcellmigrationpositiveregulationofnaturalkillercellchemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofproteinkinaseBsignalingpositiveregulationoftumornecrosisfactorproductionproteinkinaseBsignalingregulationofbehaviorregulationofcellshaperegulationofsensoryperceptionofpainreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolresponsetotoxicsubstancesignalingTcellchemotaxis
Copper-transporting ATPase 1
22
Copper transport protein ATOX1
12
2.4
65
0.64
ATP7AATOX1Q04656O00244bloodvesseldevelopmentbloodvesselremodelingcartilagedevelopmentcatecholaminemetabolicprocesscellularcopperionhomeostasiscellularresponsetoaminoacidstimuluscellularresponsetoantibioticcellularresponsetocadmiumioncellularresponsetocobaltioncellularresponsetocopperioncellularresponsetohypoxiacellularresponsetoironioncellularresponsetoleadioncellularresponsetoplatelet-derivedgrowthfactorstimuluscentralnervoussystemneurondevelopmentcerebellarPurkinjecelldifferentiationcollagenfibrilorganizationcopperionexportcopperionhomeostasiscopperionimportcopperiontransportdetoxificationofcopperiondopaminemetabolicprocesselasticfiberassemblyelastinbiosyntheticprocessepinephrinemetabolicprocessextracellularmatrixorganizationfemalepregnancyhairfolliclemorphogenesisinuteroembryonicdevelopmentlactationliverdevelopmentlocomotorybehaviorlungalveolusdevelopmentmitochondrionorganizationnegativeregulationofironiontransmembranetransportneuronprojectionmorphogenesisnorepinephrinemetabolicprocesspeptidyl-lysinemodificationpigmentationpositiveregulationofcatalyticactivitypositiveregulationofcellsizepositiveregulationofepithelialcellproliferationpositiveregulationoflamellipodiumassemblypositiveregulationofmelaninbiosyntheticprocesspositiveregulationofresponsetowoundingpositiveregulationoftyrosinaseactivitypositiveregulationofvascularassociatedsmoothmusclecellmigrationpyramidalneurondevelopmentregulationofcytochrome-coxidaseactivityregulationofgeneexpressionregulationofoxidativephosphorylationremovalofsuperoxideradicalsresponsetoiron(III)ionresponsetomanganeseionresponsetozincionserotoninmetabolicprocessskindevelopmentT-helpercelldifferentiationtryptophanmetabolicprocessresponsetooxidativestress
Ferritin heavy chain
169
Ferritin heavy chain
27
2.0
50
0.99
FRIHFRIHP09528P09528immuneresponseintracellularsequesteringofironionironiontransportnegativeregulationofcellpopulationproliferationnegativeregulationoffibroblastproliferationnegativeregulationofnecroticcelldeath
Immunoglobulin heavy constant mu
452
Immunoglobulin J chain
37
2.0
74
0.66
IGHMIGJP01871P01591adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationglomerularfiltrationhumoralimmuneresponseimmuneresponsepositiveregulationofrespiratoryburstprotein-containingcomplexassemblyretinahomeostasis
Sodium channel subunit beta-4
58
Sodium channel protein type 1 subunit alpha
919
2.1
53
0.91
SCN4BSCN1AQ8IWT1P35498AVnodecellactionpotentialcardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractionestablishmentoflocalizationincellmembranedepolarizationduringcardiacmusclecellactionpotentialpositiveregulationofsodiumiontransportregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityregulationofventricularcardiacmusclecellmembranerepolarizationsodiumiontransmembranetransportsodiumiontransportadultwalkingbehaviordetectionofmechanicalstimulusinvolvedinsensoryperceptionofpainmembranedepolarizationduringactionpotentialneuromuscularprocesscontrollingpostureneuronalactionpotentialneuronalactionpotentialpropagationregulationofiontransmembranetransport
Metabotropic glutamate receptor 2
121
Metabotropic glutamate receptor 2
121
2.0
36
1.37
GRM2GRM2Q14416Q14416behavioralresponsetonicotinechemicalsynaptictransmissionGprotein-coupledglutamatereceptorsignalingpathwaygeneexpressionglutamatehomeostasisglutamatesecretionnegativeregulationofadenylatecyclaseactivityregulationofdopaminesecretionregulationofglutamatesecretionregulationofproteinkinaseBsignalingregulationofresponsetodrugregulationofsynaptictransmissionglutamatergicresponsetococaine
Igh protein
478
Immunoglobulin J chain
36
2.0
73
0.67
Q99M22IGJQ99M22P01592adaptiveimmuneresponseantibacterialhumoralresponseglomerularfiltrationhumoralimmuneresponseinnateimmuneresponsepositiveregulationofrespiratoryburstprotein-containingcomplexassembly
Broad substrate specificity ATP-binding cassette transporter ABCG2
603
Broad substrate specificity ATP-binding cassette transporter ABCG2
603
2.0
50
0.98
ABCG2ABCG2Q9UNQ0Q9UNQ0biotintransportcellulardetoxificationexportacrossplasmamembranelipidtransportorganicaniontransportrenaluratesaltexcretionriboflavintransporttransepithelialtransporttransmembranetransporttransportacrossblood-brainbarrieruratemetabolicprocessxenobiotictransportacrossblood-brainbarrier
Polymeric immunoglobulin receptor
486
Immunoglobulin heavy constant mu
291
2.0
56
0.88
PIGRIGHMP01833P01871detectionofchemicalstimulusinvolvedinsensoryperceptionofbittertasteepidermalgrowthfactorreceptorsignalingpathwayFcreceptorsignalingpathwayimmunoglobulintranscytosisinepithelialcellsmediatedbypolymericimmunoglobulinreceptorreceptorclusteringretinahomeostasisadaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Exostosin-like 3
915
Exostosin-like 3
793
2.0
82
0.6
EXTL3EXTL3O43909O43909heparansulfateproteoglycanbiosyntheticprocesspositiveregulationofcellgrowthproteinglycosylation
Pentraxin-related protein PTX3
317
Pentraxin-related protein PTX3
318
2.0
60
0.82
PTX3PTX3P26022P26022extracellularmatrixorganizationinflammatoryresponseinnateimmuneresponsenegativeregulationbyhostofviralexo-alpha-sialidaseactivitynegativeregulationbyhostofviralglycoproteinmetabolicprocessnegativeregulationbyhostofviralprocessnegativeregulationofexo-alpha-sialidaseactivitynegativeregulationofglycoproteinmetabolicprocessnegativeregulationofviralentryintohostcellopsonizationovariancumulusexpansionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphagocytosisresponsetoyeast
Syntaxin-1A
205
Vesicle-associated membrane protein 2
36
2.0
51
0.97
STX1AVAMP2P32851P63027calcium-ionregulatedexocytosisexocytosishormonesecretioninsulinsecretionintracellularproteintransportmodulationofexcitatorypostsynapticpotentialneurotransmittertransportpositiveregulationofcalciumion-dependentexocytosispositiveregulationofcatecholaminesecretionpositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofexocytosispositiveregulationofneurotransmittersecretionpositiveregulationofnorepinephrinesecretionproteinlocalizationtomembraneproteinsumoylationregulatedexocytosisregulationofexocytosisregulationofsynapticvesicleprimingresponsetogravitysecretionbycellSNAREcomplexassemblysynapticvesicledockingsynapticvesicleendocytosissynapticvesicleexocytosissynapticvesiclefusiontopresynapticactivezonemembranevesicledockingvesiclefusioncellularresponsetoinsulinstimuluseosinophildegranulationGolgitoplasmamembraneproteintransportlong-termsynapticpotentiationmembranefusionpositiveregulationofintracellularproteintransportproteintransportprotein-containingcomplexassemblyregulationofdelayedrectifierpotassiumchannelactivityregulationofvesicle-mediatedtransportresponsetoglucosevesicle-mediatedtransport
Immunoglobulin heavy constant alpha 1
352
Immunoglobulin J chain
37
2.0
67
0.74
IGHA1IGJP01876P01591adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasishumoralimmuneresponseprotein-containingcomplexassembly
Insulin receptor
674
Isoform Short of Insulin receptor
887
2.0
62
0.8
INSRINSRP06213P06213-2activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearancecarbohydratemetabolicprocesscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaylearningmalegonaddevelopmentmalesexdeterminationmemoryneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationoftranscriptionDNA-templatedtransmembranereceptorproteintyrosinekinasesignalingpathwaytransportacrossblood-brainbarrierviralentryintohostcell
4F2 cell-surface antigen heavy chain
211
Large neutral amino acids transporter small subunit 1
164
2.0
49
1.01
J3KPF3LAT1J3KPF3Q01650aminoacidtransportcarbohydratemetabolicprocessaminoacidimportacrossplasmamembranecellularresponsetoglucosestarvationcellularresponsetoL-argininecellularresponsetolipopolysaccharideisoleucinetransportL-leucineimportacrossplasmamembraneL-tryptophantransmembranetransportleucineimportacrossplasmamembraneliverregenerationnegativeregulationofautophagynegativeregulationofgeneexpressionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessneutralaminoacidtransportodontogenesisphenylalaninetransportpositiveregulationofcytokineproductioninvolvedinimmuneresponsepositiveregulationofglialcellproliferationpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-17productionpositiveregulationofinterleukin-4productionpositiveregulationofleucineimportacrossplasmamembraneresponsetohyperoxiaresponsetomuscleactivitythyroidhormonetransporttransportacrossblood-brainbarriervalinetransportxenobiotictransport
Immunoglobulin heavy constant alpha 1
352
Immunoglobulin J chain
91
2.0
79
0.62
IGHA1IGJP01876P01591adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasishumoralimmuneresponseprotein-containingcomplexassembly
Sodium channel subunit beta-2
55
Sodium channel protein type 3 subunit alpha
911
2.0
64
0.77
SCN2BSCN3AO60939Q9NY46cardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractionchemicalsynaptictransmissiongeneexpressionmembranedepolarizationduringcardiacmusclecellactionpotentialnervoussystemdevelopmentregulationofatrialcardiacmusclecellmembranedepolarizationregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityresponsetoheatresponsetopyrethroidsodiumiontransmembranetransportmembranedepolarizationduringactionpotentialneuronalactionpotentialregulationofiontransmembranetransportsodiumiontransport
von Willebrand factor
1097
von Willebrand factor
1097
2.0
67
0.74
VWFVWFP04275P04275bloodcoagulationcelladhesioncell-substrateadhesionhemostasisplateletactivationpositiveregulationofintracellularsignaltransductionresponsetowounding
T cell receptor alpha chain constant
94
T cell receptor beta constant 2
131
2.0
44
1.12
TRACA0A0G2JMB4P01848A0A0G2JMB4adaptiveimmuneresponsealpha-betaTcellactivationresponsetobacteriumTcellreceptorsignalingpathway
Igh protein
306
Igh protein
306
2.0
49
1.01
Q99M22Q99M22Q99M22Q99M22
Immunoglobulin heavy constant mu
291
Immunoglobulin heavy constant mu
291
2.0
53
0.93
IGHMIGHMP01871P01871adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
von Willebrand factor
1142
von Willebrand factor
1142
2.0
66
0.74
VWFVWFP04275P04275bloodcoagulationcelladhesioncell-substrateadhesionhemostasisplateletactivationpositiveregulationofintracellularsignaltransductionresponsetowounding
Isoform 1 of Extracellular calcium-sensing receptor
129
Isoform 1 of Extracellular calcium-sensing receptor
131
2.0
51
0.96
CASRCASRP41180-1P41180-1
Immunoglobulin heavy constant mu
452
Immunoglobulin heavy constant mu
452
2.0
47
1.05
IGHMIGHMP01871P01871adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
39S ribosomal protein L10, mitochondrial
64
39S ribosomal protein S18a, mitochondrial
70
1.8
61
0.93
RM10RT18AQ7Z7H8Q9NVS2mitochondrialtranslationtranslation
Potassium channel subfamily K member 1
69
Potassium channel subfamily K member 1
69
2.0
34
1.44
KCNK1KCNK1Q9Z2T2Q9Z2T2potassiumiontransmembranetransportregulationofrestingmembranepotentialresponsetonicotinesodiumiontransmembranetransportstabilizationofmembranepotential
Neutral and basic amino acid transport protein rBAT
114
b(0,+)-type amino acid transporter 1
144
3.0
55
0.62
SLC31BAT1Q07837P82251aminoacidtransportaspartatetransmembranetransportbasicaminoacidtransportcarbohydratemetabolicprocessgeneexpressionL-cystinetransportL-glutamatetransmembranetransportneutralaminoacidtransportprotein-containingcomplexassembly
Insulin
96
Insulin
31
2.0
67
0.74
INSINSP01308P01318activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftranscriptionDNA-templatedregulationoftransmembranetransporteractivityvasodilationwoundhealingcellularresponsetopalmitoleicacidresponsetoL-arginine
39S ribosomal protein L10, mitochondrial
64
39S ribosomal protein S18a, mitochondrial
73
2.9
61
0.56
RM10RT18AQ7Z7H8Q9NVS2mitochondrialtranslationtranslation
Immunoglobulin J chain
37
Immunoglobulin heavy constant alpha 2
339
2.0
71
0.69
IGJIGHA2P01591P01877adaptiveimmuneresponseantibacterialhumoralresponseglomerularfiltrationhumoralimmuneresponseimmuneresponseinnateimmuneresponsepositiveregulationofrespiratoryburstprotein-containingcomplexassemblyretinahomeostasisBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumphagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
39S ribosomal protein L10, mitochondrial
64
39S ribosomal protein S18a, mitochondrial
108
2.9
53
0.65
RM10RT18AQ7Z7H8Q9NVS2mitochondrialtranslationtranslation
Calcium uptake protein 2, mitochondrial
413
Calcium uptake protein 1, mitochondrial
463
2.0
52
0.94
1
✔MICU2MICU1Q8IYU8Q9BPX6calciumimportintothemitochondrionmitochondrialcalciumionhomeostasismitochondrialcalciumiontransmembranetransportnegativeregulationofmitochondrialcalciumionconcentrationpositiveregulationofmitochondrialcalciumionconcentrationcalciumionimportdefenseresponseproteinhomooligomerizationregulationofcellularhyperosmoticsalinityresponse
4F2 cell-surface antigen heavy chain
211
Large neutral amino acids transporter small subunit 2
154
2.0
47
1.05
J3KPF3LAT2J3KPF3Q9UHI5aminoacidtransportcarbohydratemetabolicprocessaminoacidimportacrossplasmamembraneglycinetransportL-alanineimportacrossplasmamembraneL-leucineimportacrossplasmamembraneleucineimportacrossplasmamembraneleucinetransportmetalionhomeostasisneutralaminoacidtransportprolinetransmembranetransportresponsetotoxicsubstancethyroidhormonetransporttransportacrossblood-brainbarriertryptophantransportvalinetransport
Sodium channel subunit beta-2
55
Sodium channel protein type 9 subunit alpha
895
2.5
72
0.57
SCN2BSCN9AO60939Q15858cardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractionchemicalsynaptictransmissiongeneexpressionmembranedepolarizationduringcardiacmusclecellactionpotentialnervoussystemdevelopmentregulationofatrialcardiacmusclecellmembranedepolarizationregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityresponsetoheatresponsetopyrethroidsodiumiontransmembranetransportbehavioralresponsetoformalininducedpaininflammatoryresponsemembranedepolarizationduringactionpotentialnegativeregulationofactionpotentialneuronalactionpotentialpost-embryonicdevelopmentregulationofiontransmembranetransportresponsetocoldresponsetotoxicsubstancesensoryperceptionofpainsodiumiontransport
Immunoglobulin heavy constant gamma 1
336
Immunoglobulin heavy constant gamma 1
336
2.0
57
0.86
A0A0A0MS08A0A0A0MS08A0A0A0MS08A0A0A0MS08
Immunoglobulin heavy constant alpha 2
339
Immunoglobulin heavy constant alpha 2
339
2.0
45
1.1
IGHA2IGHA2P01877P01877adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
High affinity immunoglobulin epsilon receptor subunit alpha
156
Immunoglobulin heavy constant epsilon
335
2.7
37
1.01
FCERAIGHEP12319P01854cellsurfacereceptorsignalingpathwayregulationofimmuneresponseadaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Immunoglobulin heavy constant alpha 2
339
Immunoglobulin J chain
91
2.0
68
0.73
IGHA2IGJP01877P01591adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasishumoralimmuneresponseprotein-containingcomplexassembly
GPI-anchor transamidase
92
GPI transamidase component PIG-T
182
2.0
80
0.61
GPI8PIGTQ92643Q969N2attachmentofGPIanchortoproteinproteinlocalizationtocellsurfaceproteolysisneuronapoptoticprocessneurondifferentiation
Immunoglobulin heavy constant alpha 2
167
Immunoglobulin heavy constant alpha 2
110
2.0
nan
nan
IGHA2IGHA2P01877P01877adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
70
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
70
2.0
56
0.88
GNPTAGNPTAQ3T906Q3T906carbohydratephosphorylationlysosomeorganizationN-glycanprocessingtolysosomesecretionoflysosomalenzymes
Insulin receptor
710
Insulin receptor
710
2.0
44
1.12
INSRINSRP06213P06213activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearancecarbohydratemetabolicprocesscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaylearningmalegonaddevelopmentmalesexdeterminationmemoryneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationoftranscriptionDNA-templatedtransmembranereceptorproteintyrosinekinasesignalingpathwaytransportacrossblood-brainbarrierviralentryintohostcell
Ig kappa-b4 chain C region
103
IgG heavy chain VDJ region
133
2.0
nan
nan
KAC4A0A1Y1B8B1P01840A0A1Y1B8B1
B-cell antigen receptor complex-associated protein alpha chain
119
B-cell antigen receptor complex-associated protein beta chain
136
2.1
79
0.62
CD79ACD79BP11912P40259adaptiveimmuneresponseBcellactivationBcelldifferentiationBcellproliferationBcellreceptorsignalingpathwayimmuneresponsesignaltransduction
Insulin receptor
714
Insulin receptor
711
2.0
nan
nan
INSRINSRP15208P15208activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearanceanimalorganmorphogenesiscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaymalegonaddevelopmentmalesexdeterminationnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofproteinphosphorylationnegativeregulationoftransporteractivityneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationofhydrogenperoxidemetabolicprocessregulationoftranscriptionDNA-templatedresponsetonutrientlevelsresponsetotumornecrosisfactortransmembranereceptorproteintyrosinekinasesignalingpathwayviralentryintohostcell
Large neutral amino acids transporter small subunit 1
164
4F2 cell-surface antigen heavy chain
210
2.0
50
0.99
LAT14F2Q01650P08195aminoacidimportacrossplasmamembranecellularresponsetoglucosestarvationcellularresponsetoL-argininecellularresponsetolipopolysaccharideisoleucinetransportL-leucineimportacrossplasmamembraneL-tryptophantransmembranetransportleucineimportacrossplasmamembraneliverregenerationnegativeregulationofautophagynegativeregulationofgeneexpressionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessneutralaminoacidtransportodontogenesisphenylalaninetransportpositiveregulationofcytokineproductioninvolvedinimmuneresponsepositiveregulationofglialcellproliferationpositiveregulationofinterferon-gammaproductionpositiveregulationofinterleukin-17productionpositiveregulationofinterleukin-4productionpositiveregulationofleucineimportacrossplasmamembraneresponsetohyperoxiaresponsetomuscleactivitythyroidhormonetransporttransportacrossblood-brainbarriervalinetransportxenobiotictransportaminoacidtransportcalciumiontransportcarbohydratemetabolicprocessL-alanineimportacrossplasmamembraneleucinetransportresponsetoexogenousdsRNAtryptophantransportviralentryintohostcell
Glial cell line-derived neurotrophic factor
178
Glial cell line-derived neurotrophic factor
178
2.1
63
0.76
GDNFGDNFP39905P39905adultlocomotorybehaviorbranchinginvolvedinuretericbudmorphogenesiscommissuralneuronaxonguidancedorsalspinalcorddevelopmentembryonicorgandevelopmententericnervoussystemdevelopmentmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesismetanephrosdevelopmentmRNAstabilizationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofneuronapoptoticprocessnervoussystemdevelopmentneuralcrestcellmigrationneuronprojectiondevelopmentorganinductionperipheralnervoussystemdevelopmentperistalsispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofdopaminesecretionpositiveregulationofmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesispositiveregulationofmonooxygenaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofuretericbudformationpostganglionicparasympatheticfiberdevelopmentpostsynapticmembraneorganizationregulationofdopamineuptakeinvolvedinsynaptictransmissionregulationofgeneexpressionregulationofmorphogenesisofabranchingstructureregulationofsemaphorin-plexinsignalingpathwayregulationofstemcelldifferentiationsignaltransductionsympatheticnervoussystemdevelopmenturetericbudformation
Insulin receptor
674
Insulin receptor
899
2.0
57
0.86
INSRINSRP06213P06213activationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentamyloid-betaclearancecarbohydratemetabolicprocesscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusdendriticspinemaintenanceepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayglucosehomeostasisheartmorphogenesisinsulinreceptorsignalingpathwaylearningmalegonaddevelopmentmalesexdeterminationmemoryneuronprojectionmaintenancepeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinautophosphorylationproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationoftranscriptionDNA-templatedtransmembranereceptorproteintyrosinekinasesignalingpathwaytransportacrossblood-brainbarrierviralentryintohostcell
Isoform 3 of Metabotropic glutamate receptor 7
136
Isoform 3 of Metabotropic glutamate receptor 7
136
2.0
nan
nan
GRM7GRM7Q14831-3Q14831-3
Insulin-like growth factor 1 receptor
700
Insulin-like growth factor 1 receptor
700
2.0
nan
nan
IGF1RIGF1RP08069P08069agingamyloid-betaclearanceaxonogenesiscardiacatriumdevelopmentcellularresponsetoaldosteronecellularresponsetoamyloid-betacellularresponsetoangiotensincellularresponsetodexamethasonestimuluscellularresponsetoestradiolstimuluscellularresponsetoglucosestimuluscellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetomechanicalstimuluscellularresponsetoprogesteronestimuluscellularresponsetotestosteronestimuluscellularresponsetotransforminggrowthfactorbetastimuluscellularsenescencecerebellumdevelopmentdendriticspinemaintenanceestablishmentofcellpolarityestrouscycleglucosehomeostasishippocampusdevelopmentimmuneresponseinsulinreceptorsignalingpathwayinsulin-likegrowthfactorreceptorsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofcholangiocyteapoptoticprocessnegativeregulationofhepatocyteapoptoticprocessnegativeregulationofMAPKcascadenegativeregulationofmusclecellapoptoticprocesspeptidyl-tyrosineautophosphorylationphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofaxonregenerationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcold-inducedthermogenesispositiveregulationofcytokinesispositiveregulationofDNAmetabolicprocesspositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofosteoblastproliferationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsteroidhormonebiosyntheticprocessproteinautophosphorylationregulationofJNKcascaderesponsetoethanolresponsetoL-glutamateresponsetonicotineresponsetovitaminEsignaltransductiontranscytosistransmembranereceptorproteintyrosinekinasesignalingpathway
Glutamate receptor ionotropic, NMDA 2A
745
Glutamate receptor ionotropic, NMDA 1
798
2.0
61
0.81
NMDE1NMDZ1Q12879Q05586activationofcysteine-typeendopeptidaseactivitybraindevelopmentcalciumiontransmembraneimportintocytosolcationtransmembranetransportchemicalsynaptictransmissiondirectionallocomotiondopaminemetabolicprocessexcitatorychemicalsynaptictransmissionexcitatorypostsynapticpotentialglutamatereceptorsignalingpathwayionotropicglutamatereceptorsignalingpathwaylearningormemorylong-termsynapticpotentiationmemorynegativeregulationofproteincatabolicprocessneurogenesispositiveregulationofapoptoticprocesspositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofsynaptictransmissionglutamatergicproteincatabolicprocessproteinlocalizationtopostsynapticmembraneregulationofcationtransmembranetransportregulationofneuronalsynapticplasticityregulationofsynapticplasticityresponsetoamphetamineresponsetoethanolresponsetowoundingresponsetoxenobioticstimulussensoryperceptionofpainserotoninmetabolicprocesssleepstartleresponsevisuallearningcalciumionhomeostasiscationtransportpositiveregulationofcalciumiontransportintocytosolpositiveregulationofcysteine-typeendopeptidaseactivitypositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpropylenemetabolicprocessproteinheterotetramerizationregulationofmembranepotentialresponsetoglycine
Two pore channel protein 2
623
Two pore channel protein 2
623
2.0
40
1.22
TPC2TPC2Q8NHX9Q8NHX9calcium-mediatedsignalingcellularcalciumionhomeostasisendocytosisinvolvedinviralentryintohostcellendosometolysosometransportoflow-densitylipoproteinparticleiontransmembranetransportlysosomeorganizationreceptor-mediatedendocytosisofvirusbyhostcellregulationofautophagyregulationofexocytosisregulationofiontransmembranetransportresponsetovitaminDsmoothmusclecontractionsodiumiontransmembranetransport
Mucin-2
1130
Mucin-2
1130
2.0
52
0.95
A0A0G2JR65A0A0G2JR65A0A0G2JR65A0A0G2JR65
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
149
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
141
2.0
79
0.62
NDUBANDUBBO96000Q9NX14aerobicrespirationmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyprotonmotiveforce-drivenmitochondrialATPsynthesis
Polymeric immunoglobulin receptor
486
Immunoglobulin heavy constant alpha 2
179
2.0
59
0.83
PIGRIGHA2P01833P01877detectionofchemicalstimulusinvolvedinsensoryperceptionofbittertasteepidermalgrowthfactorreceptorsignalingpathwayFcreceptorsignalingpathwayimmunoglobulintranscytosisinepithelialcellsmediatedbypolymericimmunoglobulinreceptorreceptorclusteringretinahomeostasisadaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburst
Insulin-like growth factor 1 receptor
701
Insulin-like growth factor 1 receptor
701
2.0
nan
nan
IGF1RIGF1RQ60751Q60751adrenalglanddevelopmentamyloid-betaclearanceanimalorganmorphogenesisaxonogenesisbraindevelopmentcellularresponsetoamyloid-betacellularresponsetoglucosestimuluscellularresponsetoinsulinstimuluscellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetotransforminggrowthfactorbetastimuluscerebellumdevelopmentdendriticspinemaintenanceepidermisdevelopmentestablishmentofcellpolarityestrouscycleexocrinepancreasdevelopmentglucosehomeostasisimmuneresponseinsulinreceptorsignalingpathwayinsulin-likegrowthfactorreceptorsignalingpathwaymalesexdeterminationmammaryglanddevelopmentMAPKcascademitoticnucleardivisionnegativeregulationofapoptoticprocessnegativeregulationofcholangiocyteapoptoticprocessnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofhepatocyteapoptoticprocessnegativeregulationofMAPKcascadenegativeregulationofmusclecellapoptoticprocessnegativeregulationofproteinkinaseBsignalingneuronprojectiondevelopmentpeptidyl-tyrosineautophosphorylationphosphatidylinositol-mediatedsignalingpositiveregulationofaxonregenerationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcold-inducedthermogenesispositiveregulationofcytokinesispositiveregulationofdevelopmentalgrowthpositiveregulationofDNAmetabolicprocesspositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastproliferationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsteroidhormonebiosyntheticprocesspositiveregulationoftranscriptionDNA-templatedprostateglandepitheliummorphogenesisproteinautophosphorylationproteinkinaseBsignalingproteinphosphorylationregulationofJNKcascaderesponsetoethanolresponsetoL-glutamatetranscytosistransmembranereceptorproteintyrosinekinasesignalingpathway
Polymeric immunoglobulin receptor
486
Immunoglobulin heavy constant alpha 1
192
2.0
58
0.84
PIGRIGHA1P01833P01876detectionofchemicalstimulusinvolvedinsensoryperceptionofbittertasteepidermalgrowthfactorreceptorsignalingpathwayFcreceptorsignalingpathwayimmunoglobulintranscytosisinepithelialcellsmediatedbypolymericimmunoglobulinreceptorreceptorclusteringretinahomeostasisadaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburst
Large neutral amino acids transporter small subunit 2
154
4F2 cell-surface antigen heavy chain
210
2.0
46
1.07
LAT24F2Q9UHI5P08195aminoacidimportacrossplasmamembraneaminoacidtransportglycinetransportL-alanineimportacrossplasmamembraneL-leucineimportacrossplasmamembraneleucineimportacrossplasmamembraneleucinetransportmetalionhomeostasisneutralaminoacidtransportprolinetransmembranetransportresponsetotoxicsubstancethyroidhormonetransporttransportacrossblood-brainbarriertryptophantransportvalinetransportcalciumiontransportcarbohydratemetabolicprocessphenylalaninetransportresponsetoexogenousdsRNAviralentryintohostcell
Isoform 2 of Immunoglobulin heavy constant mu
214
Isoform 2 of Immunoglobulin heavy constant mu
214
2.0
54
0.91
IGHMIGHMP01871-2P01871-2
Immunoglobulin kappa constant
107
Immunoglobulin gamma-1 heavy chain
222
2.0
nan
nan
IGKCIGG1P01834P0DOX5adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationretinahomeostasis
Potassium channel TASK2
51
Potassium channel TASK2
51
2.0
35
1.41
Q9JK62Q9JK62Q9JK62Q9JK62potassiumionexportacrossplasmamembranepotassiumionimportacrossplasmamembranepotassiumiontransmembranetransportpotassiumiontransportregulationofrestingmembranepotentialstabilizationofmembranepotential
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
144
NADH-ubiquinone oxidoreductase chain 5
279
2.0
73
0.67
NDUB8X5BVZ3O95169X5BVZ3aerobicrespirationmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyprotonmotiveforce-drivenmitochondrialATPsynthesisATPsynthesiscoupledelectrontransport
4F2 cell-surface antigen heavy chain
210
Cystine/glutamate transporter
158
2.0
43
1.15
4F2XCTP08195Q9UPY5aminoacidtransportcalciumiontransportcarbohydratemetabolicprocessL-alanineimportacrossplasmamembraneL-leucineimportacrossplasmamembraneleucineimportacrossplasmamembraneleucinetransportphenylalaninetransportresponsetoexogenousdsRNAtryptophantransportviralentryintohostcelladultbehaviorcellularresponsetooxidativestressdipeptideimportacrossplasmamembraneglutamatehomeostasisglutathionemetabolicprocessglutathionetransmembranetransportL-glutamateimportacrossplasmamembranelensfibercelldifferentiationlimbdevelopmentlungalveolusdevelopmentmodulationofchemicalsynaptictransmissionnegativeregulationofoxidativestress-inducedneurondeathplateletaggregationregulationofAMPAglutamatereceptorclusteringregulationofcellpopulationproliferationregulationofcysteinemetabolicprocessregulationofglutamatemetabolicprocessregulationofglutathionebiosyntheticprocessregulationofmelaninbiosyntheticprocessregulationofneutrophilapoptoticprocessregulationofproteintransportregulationofsynapseorganizationresponsetonicotineresponsetoorganiccycliccompoundresponsetoredoxstateresponsetotoxicsubstancestriatumdevelopmentventricularsystemdevelopmentvisuallearning
Uncharacterized protein
248
IGK@ protein
236
2.0
nan
nan
Q6N095Q6PIL8Q6N095Q6PIL8
Igh protein
478
Immunoglobulin J chain
90
2.0
81
0.61
Q99M22IGJQ99M22P01592adaptiveimmuneresponseantibacterialhumoralresponseglomerularfiltrationhumoralimmuneresponseinnateimmuneresponsepositiveregulationofrespiratoryburstprotein-containingcomplexassembly
Transforming growth factor beta-1 proprotein
33
Transforming growth factor beta activator LRRC33
219
2.0
59
0.83
TGFB1LRC33P01137Q86YC3aorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaycellmigrationcell-celljunctionorganizationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluschondrocytedifferentiationcommon-partnerSMADproteinphosphorylationconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingembryonicliverdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayheartdevelopmentheartvalvemorphogenesishematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphnodedevelopmentmacrophagederivedfoamcelldifferentiationMAPKcascademembraneproteinintracellulardomainproteolysisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofcytolysisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixdisassemblynegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofmacrophagecytokineproductionnegativeregulationofmiRNAmaturationnegativeregulationofmiRNAtranscriptionnegativeregulationofmiRNA-mediatedgenesilencingnegativeregulationofmyoblastdifferentiationnegativeregulationofproteinlocalizationtoplasmamembranenegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationoftranscriptionDNA-templatedneuraltubeclosureneuraltubedevelopmentossificationinvolvedinboneremodelingpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixassemblypositiveregulationoffibroblastmigrationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationofSMADproteinsignaltransductionpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularpermeabilityproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofbindingregulationofbloodvesselremodelingregulationofcellmigrationregulationofcellpopulationproliferationregulationofDNAbindingregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesisimmuneresponsemicrogliadevelopmentsequesteringofTGFbetainextracellularmatrixsuperoxidemetabolicprocesstransforminggrowthfactorbeta1activation
Uncharacterized protein
245
IGL@ protein
232
2.3
nan
nan
Q6N089Q8N5F4Q6N089Q8N5F4
4F2 cell-surface antigen heavy chain
211
Cystine/glutamate transporter
158
2.0
40
1.23
J3KPF3XCTJ3KPF3Q9UPY5aminoacidtransportcarbohydratemetabolicprocessadultbehaviorcellularresponsetooxidativestressdipeptideimportacrossplasmamembraneglutamatehomeostasisglutathionemetabolicprocessglutathionetransmembranetransportL-glutamateimportacrossplasmamembranelensfibercelldifferentiationlimbdevelopmentlungalveolusdevelopmentmodulationofchemicalsynaptictransmissionnegativeregulationofoxidativestress-inducedneurondeathplateletaggregationregulationofAMPAglutamatereceptorclusteringregulationofcellpopulationproliferationregulationofcysteinemetabolicprocessregulationofglutamatemetabolicprocessregulationofglutathionebiosyntheticprocessregulationofmelaninbiosyntheticprocessregulationofneutrophilapoptoticprocessregulationofproteintransportregulationofsynapseorganizationresponsetonicotineresponsetoorganiccycliccompoundresponsetoredoxstateresponsetotoxicsubstancestriatumdevelopmentventricularsystemdevelopmentvisuallearning
Ferritin heavy chain
237
Ferritin heavy chain
31
2.0
39
1.27
FRIHFRIHP09528P09528immuneresponseintracellularsequesteringofironionironiontransportnegativeregulationofcellpopulationproliferationnegativeregulationoffibroblastproliferationnegativeregulationofnecroticcelldeath
Microtubule-associated protein tau
639
Microtubule-associated protein tau
639
2.0
68
0.73
TAUTAUP10636P10636activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessamyloidfibrilformationastrocyteactivationaxondevelopmentaxonaltransportaxonaltransportofmitochondrioncell-cellsignalingcellularresponsetobrain-derivedneurotrophicfactorstimuluscellularresponsetoheatcellularresponsetonervegrowthfactorstimuluscellularresponsetoreactiveoxygenspeciescentralnervoussystemneurondevelopmentcytoplasmicmicrotubuleorganizationgenerationofneuronsinternalproteinaminoacidacetylationintracellulardistributionofmitochondrialearningormemorymemorymicroglialcellactivationmicrotubulecytoskeletonorganizationmicrotubulepolymerizationnegativeregulationofestablishmentofproteinlocalizationtomitochondrionnegativeregulationofgeneexpressionnegativeregulationofkinaseactivitynegativeregulationofmitochondrialfissionnegativeregulationofmitochondrialmembranepotentialnegativeregulationoftubulindeacetylationneurofibrillarytangleassemblyneuronprojectiondevelopmentplus-end-directedorganelletransportalongmicrotubulepositiveregulationofaxonextensionpositiveregulationofdiacylglycerolkinaseactivitypositiveregulationofmicrotubulepolymerizationpositiveregulationofneurondeathpositiveregulationofproteinlocalizationpositiveregulationofproteinlocalizationtosynapsepositiveregulationofsuperoxideaniongenerationproteinhomooligomerizationproteinpolymerizationregulationofautophagyregulationofcalcium-mediatedsignalingregulationofcellularresponsetoheatregulationofchromosomeorganizationregulationoflong-termsynapticdepressionregulationofmicrotubulecytoskeletonorganizationregulationofmicrotubulepolymerizationregulationofmicrotubulepolymerizationordepolymerizationregulationofmitochondrialfissionregulationofresponsetoDNAdamagestimulusregulationofsynapticplasticityresponsetoleadionrRNAmetabolicprocessstressgranuleassemblysupramolecularfiberorganizationsynapseassemblysynapseorganization
Syntaxin-1A
271
Vesicle-associated membrane protein 2
36
2.0
53
0.93
STX1AVAMP2P32851P63045calcium-ionregulatedexocytosisexocytosishormonesecretioninsulinsecretionintracellularproteintransportmodulationofexcitatorypostsynapticpotentialneurotransmittertransportpositiveregulationofcalciumion-dependentexocytosispositiveregulationofcatecholaminesecretionpositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofexocytosispositiveregulationofneurotransmittersecretionpositiveregulationofnorepinephrinesecretionproteinlocalizationtomembraneproteinsumoylationregulatedexocytosisregulationofexocytosisregulationofsynapticvesicleprimingresponsetogravitysecretionbycellSNAREcomplexassemblysynapticvesicledockingsynapticvesicleendocytosissynapticvesicleexocytosissynapticvesiclefusiontopresynapticactivezonemembranevesicledockingvesiclefusioncellularresponsetoinsulinstimuluseosinophildegranulationexocyticinsertionofneurotransmitterreceptortopostsynapticmembraneGolgitoplasmamembraneproteintransportlong-termsynapticpotentiationmembranefusionpositiveregulationofintracellularproteintransportproteintransportprotein-containingcomplexassemblyregulationofdelayedrectifierpotassiumchannelactivityregulationofsynapticvesiclerecyclingregulationofvesicle-mediatedtransportresponsetoglucosevesicle-mediatedtransport
Teneurin-4
2585
Teneurin-4
2585
2.0
42
1.18
TEN4TEN4Q6N022Q6N022cardiaccellfatespecificationcardiacmusclecellproliferationcentralnervoussystemmyelinformationgastrulationwithmouthformingsecondheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesneurondevelopmentpositiveregulationofgastrulationpositiveregulationofmyelinationpositiveregulationofoligodendrocytedifferentiationregulationofmyelinationsignaltransduction
Translation initiation factor eIF-2B subunit beta
198
Translation initiation factor eIF-2B subunit delta
465
2.0
61
0.81
EI2BBEI2BDP49770Q9UI10centralnervoussystemdevelopmentmyelinationoligodendrocytedevelopmentovarianfollicledevelopmentregulationofcatalyticactivityregulationoftranslationalinitiationresponsetoglucoseresponsetoheatresponsetopeptidehormoneTcellreceptorsignalingpathwaytranslationalinitiationregulationoftranslation
Glutamate receptor ionotropic, NMDA 1
831
Glutamate receptor ionotropic, NMDA 2B
321
2.0
41
1.2
NMDZ1NMDE2P35439Q00960adultlocomotorybehaviorassociativelearningcalciumionhomeostasiscalciumiontransmembraneimportintocytosolcalciumiontransportcationtransmembranetransportcationtransportcellularcalciumionhomeostasiscellularresponsetomanganeseioncerebralcortexdevelopmentchemicalsynaptictransmissionconditionedtasteaversionexcitatorypostsynapticpotentialionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylong-termmemorymalematingbehaviormemorynegativeregulationofneuronapoptoticprocessneuromuscularprocessolfactorylearningponsmaturationpositiveregulationofapoptoticprocesspositiveregulationofcalciumiontransportintocytosolpositiveregulationofcelldeathpositiveregulationofcysteine-typeendopeptidaseactivitypositiveregulationofdendriticspinemaintenancepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofSchwanncellmigrationpositiveregulationofsynaptictransmissionglutamatergicpositiveregulationoftranscriptionbyRNApolymeraseIIprepulseinhibitionpropylenemetabolicprocessproteinheterotetramerizationproteinlocalizationtopostsynapticmembraneprotein-containingcomplexassemblyregulationofaxonogenesisregulationofcationtransmembranetransportregulationofcellcommunicationregulationofdendritemorphogenesisregulationoflong-termneuronalsynapticplasticityregulationofmembranepotentialregulationofneuronapoptoticprocessregulationofneuronalsynapticplasticityregulationofrespiratorygaseousexchangeregulationofsynapseassemblyregulationofsynapticplasticityresponsetoamineresponsetoamphetamineresponsetocalciumionresponsetoethanolresponsetofungicideresponsetoglycineresponsetomorphineresponsetoorganiccycliccompoundrhythmicprocesssensoryperceptionofpainsocialbehaviorstartleresponsesucklingbehaviorsynaptictransmissionglutamatergicvisuallearningactionpotentialbehavioralfearresponsebehavioralresponsetopaincellularresponsetoaminoacidstimuluscellularresponsetocorticosteronestimuluscellularresponsetocurcumincellularresponsetodsRNAcellularresponsetoforskolincellularresponsetogrowthfactorstimuluscellularresponsetolipidcellularresponsetomagnesiumstarvationcellularresponsetoorganiccycliccompounddetectionofmechanicalstimulusinvolvedinsensoryperceptionofpainfearresponsehippocampusdevelopmentinuteroembryonicdevelopmentlong-termsynapticpotentiationmulticellularorganismalresponsetostressnegativeregulationofdendriticspinemaintenanceNMDAselectiveglutamatereceptorsignalingpathwaypositiveregulationofglutamatesecretionpositiveregulationofneurondeathpositiveregulationofsynaptictransmissionreceptorclusteringregulationofMAPKcascaderegulationofpostsynapticcytosoliccalciumionconcentrationregulationofpostsynapticmembranepotentialregulationofproteinkinaseAsignalingresponsetocarbohydrateresponsetococaineresponsetocytokineresponsetoelectricalstimulusresponsetogrowthhormoneresponsetohypoxiaresponsetomagnesiumionresponsetomanganeseionresponsetomechanicalstimulusresponsetomethylmercuryresponsetoorganonitrogencompoundresponsetootherorganismresponsetotoxicsubstancesensitizationsensoryorgandevelopment
Transforming growth factor beta-1 proprotein
33
Transforming growth factor beta activator LRRC33
363
2.0
nan
nan
TGFB1LRC33P01137Q86YC3aorticvalvemorphogenesisATPbiosyntheticprocessBMPsignalingpathwaycellmigrationcell-celljunctionorganizationcellularresponsetoorganiccycliccompoundcellularresponsetotransforminggrowthfactorbetastimuluschondrocytedifferentiationcommon-partnerSMADproteinphosphorylationconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingembryonicliverdevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialtomesenchymaltransitionextracellularmatrixassemblyextrinsicapoptoticsignalingpathwayheartdevelopmentheartvalvemorphogenesishematopoieticprogenitorcelldifferentiationhyaluronancatabolicprocessinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphnodedevelopmentmacrophagederivedfoamcelldifferentiationMAPKcascademembraneproteinintracellulardomainproteolysisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellcyclenegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofcytolysisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixdisassemblynegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofmacrophagecytokineproductionnegativeregulationofmiRNAmaturationnegativeregulationofmiRNAtranscriptionnegativeregulationofmiRNA-mediatedgenesilencingnegativeregulationofmyoblastdifferentiationnegativeregulationofproteinlocalizationtoplasmamembranenegativeregulationofproteinphosphorylationnegativeregulationofskeletalmuscletissuedevelopmentnegativeregulationoftranscriptionDNA-templatedneuraltubeclosureneuraltubedevelopmentossificationinvolvedinboneremodelingpathway-restrictedSMADproteinphosphorylationphosphate-containingcompoundmetabolicprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixassemblypositiveregulationoffibroblastmigrationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofMAPkinaseactivitypositiveregulationofmicrogliadifferentiationpositiveregulationofmiRNAmaturationpositiveregulationofmiRNAtranscriptionpositiveregulationofNAD+ADP-ribosyltransferaseactivitypositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationofSMADproteinsignaltransductionpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftranscriptionDNA-templatedpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularpermeabilityproteinexportfromnucleusproteinkinaseBsignalingproteinphosphorylationreceptorcatabolicprocessregulationofbindingregulationofbloodvesselremodelingregulationofcellmigrationregulationofcellpopulationproliferationregulationofDNAbindingregulationofproteinimportintonucleusregulationofSMADproteinsignaltransductionregulationofstriatedmuscletissuedevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoestradiolresponsetoprogesteroneresponsetowoundingsalivaryglandmorphogenesisSMADproteincomplexassemblySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayinvolvedinheartdevelopmentvasculogenesisventricularcardiacmuscletissuemorphogenesisimmuneresponsemicrogliadevelopmentsequesteringofTGFbetainextracellularmatrixsuperoxidemetabolicprocesstransforminggrowthfactorbeta1activation
B(0,+)-type amino acid transporter 1
144
neutral and basic amino acid transport protein rBAT
114
2.1
54
0.89
A0A6P3EL78A0A6P7DVK7A0A6P3EL78A0A6P7DVK7carbohydratemetabolicprocess
Sodium channel subunit beta-2
55
Sodium channel protein type 2 subunit alpha
910
2.1
73
0.66
SCN2BSCN2AO60939Q99250cardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractionchemicalsynaptictransmissiongeneexpressionmembranedepolarizationduringcardiacmusclecellactionpotentialnervoussystemdevelopmentregulationofatrialcardiacmusclecellmembranedepolarizationregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityresponsetoheatresponsetopyrethroidsodiumiontransmembranetransportcellularresponsetohypoxiaintrinsicapoptoticsignalingpathwayinresponsetoosmoticstressmembranedepolarizationduringactionpotentialmemorymyelinationneuronapoptoticprocessneuronalactionpotentialregulationofiontransmembranetransportsodiumiontransport
Cysteine desulfurase, mitochondrial
381
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
69
2.0
89
0.56
NFS1ISCUQ9Y697Q9H1K12Fe-2Sclusterassemblyironincorporationintometallo-sulfurclusteriron-sulfurclusterassemblyMo-molybdopterincofactorbiosyntheticprocesscellularironionhomeostasisnegativeregulationofironionimportacrossplasmamembranepositiveregulationofaconitatehydrataseactivitypositiveregulationofmitochondrialelectrontransportNADHtoubiquinone
Insulin-like growth factor 1 receptor
544
Insulin receptor
551
2.0
56
0.88
IGF1RINSRP08069P06213agingamyloid-betaclearanceaxonogenesiscardiacatriumdevelopmentcellularresponsetoaldosteronecellularresponsetoamyloid-betacellularresponsetoangiotensincellularresponsetodexamethasonestimuluscellularresponsetoestradiolstimuluscellularresponsetoglucosestimuluscellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetomechanicalstimuluscellularresponsetoprogesteronestimuluscellularresponsetotestosteronestimuluscellularresponsetotransforminggrowthfactorbetastimuluscellularsenescencecerebellumdevelopmentdendriticspinemaintenanceestablishmentofcellpolarityestrouscycleglucosehomeostasishippocampusdevelopmentimmuneresponseinsulinreceptorsignalingpathwayinsulin-likegrowthfactorreceptorsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofcholangiocyteapoptoticprocessnegativeregulationofhepatocyteapoptoticprocessnegativeregulationofMAPKcascadenegativeregulationofmusclecellapoptoticprocesspeptidyl-tyrosineautophosphorylationphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofaxonregenerationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcold-inducedthermogenesispositiveregulationofcytokinesispositiveregulationofDNAmetabolicprocesspositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofosteoblastproliferationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsteroidhormonebiosyntheticprocessproteinautophosphorylationregulationofJNKcascaderesponsetoethanolresponsetoL-glutamateresponsetonicotineresponsetovitaminEsignaltransductiontranscytosistransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofproteinkinaseactivityactivationofproteinkinaseBactivityadrenalglanddevelopmentcarbohydratemetabolicprocesscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimulusepidermisdevelopmentexocrinepancreasdevelopmentGprotein-coupledreceptorsignalingpathwayheartmorphogenesislearningmalegonaddevelopmentmalesexdeterminationmemoryneuronprojectionmaintenancepeptidyl-tyrosinephosphorylationpositiveregulationofdevelopmentalgrowthpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofMAPkinaseactivitypositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofproteinphosphorylationpositiveregulationofreceptorinternalizationpositiveregulationofrespiratoryburstpositiveregulationoftranscriptionDNA-templatedproteinphosphorylationreceptor-mediatedendocytosisregulationofembryonicdevelopmentregulationoffemalegonaddevelopmentregulationoftranscriptionDNA-templatedtransportacrossblood-brainbarrierviralentryintohostcell
Immunoglobulin heavy constant mu
452
Immunoglobulin J chain
91
2.0
59
0.84
IGHMIGJP01871P01591adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationglomerularfiltrationhumoralimmuneresponseimmuneresponsepositiveregulationofrespiratoryburstprotein-containingcomplexassemblyretinahomeostasis
Last updated: 2022-12-01
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